ADGRL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retina vasculature morphogenesis in camera-type eye (GO:0061299)8.14408779
2ribosomal small subunit assembly (GO:0000028)7.50585602
3definitive hemopoiesis (GO:0060216)7.27462442
4lymphangiogenesis (GO:0001946)6.81125856
5platelet dense granule organization (GO:0060155)6.66763855
6sprouting angiogenesis (GO:0002040)6.09725555
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.99946223
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.99946223
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.99167926
10wound healing, spreading of epidermal cells (GO:0035313)5.68057698
11negative regulation of blood vessel endothelial cell migration (GO:0043537)5.59315197
12megakaryocyte development (GO:0035855)5.42357554
13antigen processing and presentation via MHC class Ib (GO:0002475)5.18631197
14endothelium development (GO:0003158)4.98130113
15lymphoid progenitor cell differentiation (GO:0002320)4.97216624
16viral transcription (GO:0019083)4.80853695
17antigen processing and presentation of endogenous antigen (GO:0019883)4.77947692
18negative regulation of erythrocyte differentiation (GO:0045647)4.75346369
19chondrocyte proliferation (GO:0035988)4.68574085
20response to interferon-beta (GO:0035456)4.65036029
21vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.63118356
22positive regulation of vasculogenesis (GO:2001214)4.62418498
23phospholipid scrambling (GO:0017121)4.60290311
24secretory granule organization (GO:0033363)4.56070288
25translational termination (GO:0006415)4.53835999
26regulation of cell migration involved in sprouting angiogenesis (GO:0090049)4.51029357
27negative regulation of endothelial cell migration (GO:0010596)4.49928988
28endothelial cell morphogenesis (GO:0001886)4.49647808
29angiogenesis involved in wound healing (GO:0060055)4.35193764
30Notch signaling involved in heart development (GO:0061314)4.34557892
31patterning of blood vessels (GO:0001569)4.25860024
32blood vessel maturation (GO:0001955)4.24217880
33vascular endothelial growth factor signaling pathway (GO:0038084)4.20699175
34renal filtration (GO:0097205)4.15127570
35cell migration involved in sprouting angiogenesis (GO:0002042)4.13891711
36endothelial cell proliferation (GO:0001935)4.13429992
37basement membrane organization (GO:0071711)4.10145802
38substrate-dependent cell migration (GO:0006929)4.07804203
39cell adhesion mediated by integrin (GO:0033627)4.06676951
40endothelial cell differentiation (GO:0045446)4.05148860
41regulation of blood vessel endothelial cell migration (GO:0043535)4.03500411
42response to interferon-alpha (GO:0035455)4.03441179
43negative regulation of nitric oxide biosynthetic process (GO:0045019)3.98991450
44translational elongation (GO:0006414)3.95176407
45regulation of endothelial cell differentiation (GO:0045601)3.94799540
46mature B cell differentiation involved in immune response (GO:0002313)3.92539762
47negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.92139335
48negative regulation of T-helper cell differentiation (GO:0045623)3.92139335
49positive regulation of B cell differentiation (GO:0045579)3.91656572
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90158194
51artery development (GO:0060840)3.88233151
52embryonic hemopoiesis (GO:0035162)3.79958171
53positive regulation of endothelial cell differentiation (GO:0045603)3.79924203
54cotranslational protein targeting to membrane (GO:0006613)3.79403588
55protein targeting to ER (GO:0045047)3.77170674
56L-fucose catabolic process (GO:0042355)3.76238929
57fucose catabolic process (GO:0019317)3.76238929
58L-fucose metabolic process (GO:0042354)3.76238929
59endosome to melanosome transport (GO:0035646)3.75845753
60endosome to pigment granule transport (GO:0043485)3.75845753
61positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72245747
62negative regulation of focal adhesion assembly (GO:0051895)3.68705844
63negative regulation of cell junction assembly (GO:1901889)3.68705844
64negative regulation of adherens junction organization (GO:1903392)3.68705844
65lymph vessel development (GO:0001945)3.64440670
66positive regulation of urine volume (GO:0035810)3.63334621
67wound healing, spreading of cells (GO:0044319)3.61221218
68regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.60583319
69protein localization to endoplasmic reticulum (GO:0070972)3.59650116
70establishment of protein localization to endoplasmic reticulum (GO:0072599)3.58883588
71regulation of endothelial cell migration (GO:0010594)3.58800281
72endodermal cell differentiation (GO:0035987)3.56274855
73ribosomal small subunit biogenesis (GO:0042274)3.56213852
74angiogenesis (GO:0001525)3.55820400
75ventricular trabecula myocardium morphogenesis (GO:0003222)3.54591656
76DNA deamination (GO:0045006)3.52520950
77response to protozoan (GO:0001562)3.51757880
78defense response to protozoan (GO:0042832)3.50563885
79viral life cycle (GO:0019058)3.47304538
80blood vessel endothelial cell migration (GO:0043534)3.47136382
81necroptotic process (GO:0070266)3.45996481
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.43950072
83lymph node development (GO:0048535)3.39488995
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39077766
85positive regulation of endothelial cell migration (GO:0010595)3.38746214
86trabecula morphogenesis (GO:0061383)3.38090563
87heart trabecula formation (GO:0060347)3.37751642
88heart trabecula morphogenesis (GO:0061384)3.37213985
89negative regulation of epithelial cell migration (GO:0010633)3.36902511
90positive regulation of odontogenesis (GO:0042482)3.35432776
91positive regulation of receptor recycling (GO:0001921)3.35264220
92negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34571291
93substrate adhesion-dependent cell spreading (GO:0034446)3.32855510
94maturation of SSU-rRNA (GO:0030490)3.31320797
95hyaluronan catabolic process (GO:0030214)3.30262672
96regulation of vasculogenesis (GO:2001212)3.28311078
97cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.27212815
98negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.26558279
99regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.26360963
100neuron projection extension involved in neuron projection guidance (GO:1902284)3.25318146
101axon extension involved in axon guidance (GO:0048846)3.25318146
102T cell homeostasis (GO:0043029)3.23322991
103positive regulation of gamma-delta T cell activation (GO:0046645)3.19565793
104mast cell activation (GO:0045576)3.17161141
105cellular protein complex disassembly (GO:0043624)3.16039873
106vasculogenesis (GO:0001570)3.15796002
107purine-containing compound salvage (GO:0043101)3.14892212
108positive regulation of T cell mediated cytotoxicity (GO:0001916)3.14117718
109response to type I interferon (GO:0034340)3.13358149
110regulation of integrin-mediated signaling pathway (GO:2001044)3.12358205
111positive regulation of cell junction assembly (GO:1901890)3.12203130
112positive regulation of focal adhesion assembly (GO:0051894)3.12203130
113mucosal-associated lymphoid tissue development (GO:0048537)3.10940228
114Peyers patch development (GO:0048541)3.10940228
115cellular response to type I interferon (GO:0071357)3.08245370
116type I interferon signaling pathway (GO:0060337)3.08245370
117negative regulation of angiogenesis (GO:0016525)3.07614256
118regulation of B cell differentiation (GO:0045577)3.04944249
119negative regulation of endothelial cell apoptotic process (GO:2000352)3.03998214
120cellular response to thyroid hormone stimulus (GO:0097067)3.02682081
121endothelial tube morphogenesis (GO:0061154)3.01288254
122morphogenesis of an endothelium (GO:0003159)3.01288254
123negative regulation of endothelial cell proliferation (GO:0001937)3.00954935
124positive regulation of respiratory burst (GO:0060267)3.00821233
125CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.00286823
126regulation of endothelial cell apoptotic process (GO:2000351)3.00266471
127histamine transport (GO:0051608)2.98186178
128positive regulation of adherens junction organization (GO:1903393)2.97060537
129negative regulation of blood vessel morphogenesis (GO:2000181)2.95803610
130negative regulation of nitric-oxide synthase activity (GO:0051001)2.95415531
131regulation of T cell mediated cytotoxicity (GO:0001914)2.95037552
132positive regulation of endothelial cell apoptotic process (GO:2000353)2.93481484
133regulation of erythrocyte differentiation (GO:0045646)2.93264612
134negative regulation of viral entry into host cell (GO:0046597)2.92971323
135mast cell degranulation (GO:0043303)2.92791424
136mast cell activation involved in immune response (GO:0002279)2.92791424
137regulation of necroptotic process (GO:0060544)2.92482464
138blood vessel remodeling (GO:0001974)2.90751064
139translational initiation (GO:0006413)2.90691803
140negative regulation of anoikis (GO:2000811)2.90518282
141regulation of epithelial cell migration (GO:0010632)2.89354058
142hematopoietic stem cell proliferation (GO:0071425)2.88067051
143positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.87140086
144negative regulation of chondrocyte differentiation (GO:0032331)2.86059913
145leukocyte homeostasis (GO:0001776)2.85888189
146negative regulation of stress fiber assembly (GO:0051497)2.85884597
147positive regulation of epithelial cell migration (GO:0010634)2.85624950
148ganglion development (GO:0061548)2.85369789
149regulation of focal adhesion assembly (GO:0051893)2.85151454
150regulation of cell-substrate junction assembly (GO:0090109)2.85151454
151mature B cell differentiation (GO:0002335)2.85040271
152endothelial cell migration (GO:0043542)2.85039023
153cytokine production involved in immune response (GO:0002367)2.82824881
154protein complex disassembly (GO:0043241)2.82368370
155IMP metabolic process (GO:0046040)2.82153436
156negative regulation of vasculature development (GO:1901343)2.82153126
157positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.81800722
158negative regulation of platelet activation (GO:0010544)2.81118684
159polyketide metabolic process (GO:0030638)2.81037332
160doxorubicin metabolic process (GO:0044598)2.81037332
161daunorubicin metabolic process (GO:0044597)2.81037332
162regulation of natural killer cell differentiation (GO:0032823)2.79442296
163programmed necrotic cell death (GO:0097300)2.79348062
164regulation of chemokine-mediated signaling pathway (GO:0070099)2.79077443
165regulation of adherens junction organization (GO:1903391)2.78106654
166protein localization to endosome (GO:0036010)2.78045997
167negative regulation of protein autophosphorylation (GO:0031953)2.76863620
168regulation of gamma-delta T cell differentiation (GO:0045586)2.76113017
169surfactant homeostasis (GO:0043129)2.75829444
170positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.75821736
171regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74949157
172positive regulation of blood vessel endothelial cell migration (GO:0043536)2.73276842
173glomerular filtration (GO:0003094)2.73260497
174macrophage differentiation (GO:0030225)2.73247902
175nephron epithelium development (GO:0072009)2.72746791
176negative regulation of cell-substrate adhesion (GO:0010812)2.71606349
177nuclear-transcribed mRNA catabolic process (GO:0000956)2.71027432
178negative regulation of DNA biosynthetic process (GO:2000279)2.70933331
179cell migration involved in heart development (GO:0060973)2.70549288
180positive regulation of lipid kinase activity (GO:0090218)2.70094237
181regulation of establishment or maintenance of cell polarity (GO:0032878)2.70062565
182regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.68430451
183embryonic heart tube development (GO:0035050)2.66634592
184positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.65529418
185positive regulation of endothelial cell proliferation (GO:0001938)2.63521749
186heparin biosynthetic process (GO:0030210)2.62695590
187heparin metabolic process (GO:0030202)2.62695590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human5.71917428
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.30716235
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.35230974
4GATA1_22025678_ChIP-Seq_K562_Human4.11110074
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.78703725
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.73307172
7E2F7_22180533_ChIP-Seq_HELA_Human3.71028514
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.64174370
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.48232096
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22186194
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.21897782
12TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.95319169
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93295619
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.89773273
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.89133228
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.86221259
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.81666939
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76569527
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.72162327
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.71338963
21GATA2_21666600_ChIP-Seq_HMVEC_Human2.68656075
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.64957383
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60379911
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.59166681
25CDX2_19796622_ChIP-Seq_MESCs_Mouse2.55800864
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53276451
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44053945
28LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.43633323
29EP300_21415370_ChIP-Seq_HL-1_Mouse2.39477425
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39401075
31CJUN_26792858_Chip-Seq_BT549_Human2.35770795
32TP63_17297297_ChIP-ChIP_HaCaT_Human2.27599199
33MYC_18555785_ChIP-Seq_MESCs_Mouse2.24851708
34WT1_19549856_ChIP-ChIP_CCG9911_Human2.22869855
35RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19876598
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.18954634
37BRD4_25478319_ChIP-Seq_HGPS_Human2.13317793
38SALL4_18804426_ChIP-ChIP_XEN_Mouse2.11885748
39CLOCK_20551151_ChIP-Seq_293T_Human2.11787161
40SPI1_23547873_ChIP-Seq_NB4_Human2.11535389
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.09410635
42STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06345082
43VDR_21846776_ChIP-Seq_THP-1_Human2.03783170
44ERG_20887958_ChIP-Seq_HPC-7_Mouse2.03630939
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.03170611
46HOXB4_20404135_ChIP-ChIP_EML_Mouse2.00397956
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99608543
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.95821614
49MYC_22102868_ChIP-Seq_BL_Human1.88608700
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88140760
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.85511794
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.85511794
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.84360603
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.84341317
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.83042883
56VDR_24763502_ChIP-Seq_THP-1_Human1.82871761
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82074184
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.80224449
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.79561369
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79541234
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.78918641
62RUNX_20019798_ChIP-Seq_JUKART_Human1.78641996
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74352751
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.72269837
65MYB_26560356_Chip-Seq_TH2_Human1.71936520
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71155095
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.70726112
68MAF_26560356_Chip-Seq_TH1_Human1.68215236
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67877552
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67877552
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67767542
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67046063
73TCF7_22412390_ChIP-Seq_EML_Mouse1.66686826
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64719960
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.62684015
76MYB_26560356_Chip-Seq_TH1_Human1.61658138
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59066714
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.58238860
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57534044
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54154178
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54087146
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53610761
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.53329336
84PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.52722481
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52300856
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.47077257
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46334254
88SPI1_23127762_ChIP-Seq_K562_Human1.45529262
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41839396
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.38761940
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37796337
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37305288
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.36794252
94FOXP3_21729870_ChIP-Seq_TREG_Human1.33883567
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33807604
96GATA1_19941826_ChIP-Seq_K562_Human1.33021257
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.32927574
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32711864
99RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32634066
100EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32634066
101SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31952809
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.31705119
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30435419
104SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30435419
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29854690
106MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28752472
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.27384311
108UTX_26944678_Chip-Seq_JUKART_Human1.26794692
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26769159
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26327442
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23169695
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22254581
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20516934
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20243194
115SRF_21415370_ChIP-Seq_HL-1_Mouse1.19199254
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18344645
117SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18022364
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17612399
119CIITA_25753668_ChIP-Seq_RAJI_Human1.17292989
120ESR1_21235772_ChIP-Seq_MCF-7_Human1.17176391
121VDR_23849224_ChIP-Seq_CD4+_Human1.16847648
122SOX2_20726797_ChIP-Seq_SW620_Human1.15628165
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15476585
124NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15086339
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12726044
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12156399
127ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12127603
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10140238
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10023580
130TCF4_18268006_ChIP-ChIP_LS174T_Human1.07832451
131TP53_18474530_ChIP-ChIP_U2OS_Human1.05556341
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04235926
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04181656
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04176757
135WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03686557
136ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03497746
137FOXO3_23340844_ChIP-Seq_DLD1_Human1.03306942
138MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03208648
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02369435
140SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01543972
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01356604
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01044493
143AHR_22903824_ChIP-Seq_MCF-7_Human1.00907057
144MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00645030
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00203926
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99309803
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98995713
148GATA3_27048872_Chip-Seq_THYMUS_Human0.98905948
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98478903
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98216912
151PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.98024021
152GATA2_19941826_ChIP-Seq_K562_Human0.97496077
153TP63_23658742_ChIP-Seq_EP156T_Human0.97406901
154ETS1_22383799_ChIP-Seq_G1ME_Mouse0.97077436
155SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96141301
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95629092
157E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95395165
158MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95148511
159ISL1_27105846_Chip-Seq_CPCs_Mouse0.94148702
160XRN2_22483619_ChIP-Seq_HELA_Human0.94059587
161GABP_17652178_ChIP-ChIP_JURKAT_Human0.92686344
162PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92623659
163KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92445861
164GATA3_26560356_Chip-Seq_TH2_Human0.91897660
165PU_27001747_Chip-Seq_BMDM_Mouse0.91610013
166FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91440555
167KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91074594
168P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91009291
169STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90898948
170TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90564852
171MAF_26560356_Chip-Seq_TH2_Human0.90400782
172NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90332915
173SA1_22415368_ChIP-Seq_MEFs_Mouse0.90048726
174RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89907915
175RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89073731
176E2F4_17652178_ChIP-ChIP_JURKAT_Human0.88930020
177LXR_22158963_ChIP-Seq_LIVER_Mouse0.88750545
178ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88696582
179MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88621611
180PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88586068
181UBF1/2_26484160_Chip-Seq_HMECs_Human0.87533362
182SMC3_22415368_ChIP-Seq_MEFs_Mouse0.87397089
183EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85751905
184RXR_22108803_ChIP-Seq_LS180_Human0.84345295
185HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.83424274
186BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83300471
187ELK1_19687146_ChIP-ChIP_HELA_Human0.82554158
188LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81952820
189PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81184694
190ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79729007
191CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79042962
192GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79012733
193NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78799888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system5.09345848
2MP0010368_abnormal_lymphatic_system4.20889096
3MP0004147_increased_porphyrin_level3.78622725
4MP0008438_abnormal_cutaneous_collagen3.64116484
5MP0001879_abnormal_lymphatic_vessel3.45432321
6MP0003724_increased_susceptibility_to3.41426797
7MP0004808_abnormal_hematopoietic_stem3.15314340
8MP0001545_abnormal_hematopoietic_system2.92450828
9MP0005397_hematopoietic_system_phenotyp2.92450828
10MP0001835_abnormal_antigen_presentation2.85312768
11MP0000465_gastrointestinal_hemorrhage2.66475535
12MP0003566_abnormal_cell_adhesion2.59663319
13MP0003705_abnormal_hypodermis_morpholog2.59318757
14MP0009785_altered_susceptibility_to2.57305093
15MP0009379_abnormal_foot_pigmentation2.52188185
16MP0009278_abnormal_bone_marrow2.49956842
17MP0005623_abnormal_meninges_morphology2.49136065
18MP0003950_abnormal_plasma_membrane2.42799768
19MP0006054_spinal_hemorrhage2.42315096
20MP0005167_abnormal_blood-brain_barrier2.41355427
21MP0005174_abnormal_tail_pigmentation2.34482135
22MP0005464_abnormal_platelet_physiology2.16203398
23MP0003828_pulmonary_edema2.07718487
24MP0005075_abnormal_melanosome_morpholog1.98169227
25MP0001873_stomach_inflammation1.94124675
26MP0005275_abnormal_skin_tensile1.89938859
27MP0005670_abnormal_white_adipose1.88478349
28MP0001853_heart_inflammation1.86011315
29MP0009697_abnormal_copulation1.85628436
30MP0005671_abnormal_response_to1.80788019
31MP0002166_altered_tumor_susceptibility1.77429853
32MP0005025_abnormal_response_to1.77183737
33MP0002295_abnormal_pulmonary_circulatio1.74342818
34MP0003191_abnormal_cellular_cholesterol1.70361021
35MP0001188_hyperpigmentation1.66850250
36MP0000685_abnormal_immune_system1.65569616
37MP0002095_abnormal_skin_pigmentation1.64138567
38MP0002398_abnormal_bone_marrow1.62360276
39MP0000013_abnormal_adipose_tissue1.61005176
40MP0002138_abnormal_hepatobiliary_system1.58134678
41MP0000343_altered_response_to1.54889516
42MP0001614_abnormal_blood_vessel1.53542730
43MP0003091_abnormal_cell_migration1.52145627
44MP0003943_abnormal_hepatobiliary_system1.50034528
45MP0000689_abnormal_spleen_morphology1.49827659
46MP0003303_peritoneal_inflammation1.48237707
47MP0000751_myopathy1.46954182
48MP0002420_abnormal_adaptive_immunity1.46090038
49MP0002933_joint_inflammation1.45210054
50MP0010155_abnormal_intestine_physiology1.44311776
51MP0003300_gastrointestinal_ulcer1.43958701
52MP0002723_abnormal_immune_serum1.43929687
53MP0002877_abnormal_melanocyte_morpholog1.43235554
54MP0001819_abnormal_immune_cell1.42382761
55MP0001800_abnormal_humoral_immune1.40124674
56MP0002452_abnormal_antigen_presenting1.39623979
57MP0004084_abnormal_cardiac_muscle1.39487957
58MP0005409_darkened_coat_color1.38448433
59MP0002925_abnormal_cardiovascular_devel1.36637418
60MP0002722_abnormal_immune_system1.35792149
61MP0002419_abnormal_innate_immunity1.33699145
62MP0003763_abnormal_thymus_physiology1.32794210
63MP0002429_abnormal_blood_cell1.30701253
64MP0000716_abnormal_immune_system1.30681295
65MP0002127_abnormal_cardiovascular_syste1.30255796
66MP0002148_abnormal_hypersensitivity_rea1.29916930
67MP0000490_abnormal_crypts_of1.25133205
68MP0003866_abnormal_defecation1.24600408
69MP0001958_emphysema1.24439419
70MP0010030_abnormal_orbit_morphology1.23381512
71MP0000003_abnormal_adipose_tissue1.21168539
72MP0005084_abnormal_gallbladder_morpholo1.21130521
73MP0005503_abnormal_tendon_morphology1.17983245
74MP0005000_abnormal_immune_tolerance1.17627613
75MP0002006_tumorigenesis1.16731641
76MP0008007_abnormal_cellular_replicative1.16083035
77MP0000749_muscle_degeneration1.14954381
78MP0005023_abnormal_wound_healing1.12501697
79MP0008469_abnormal_protein_level1.11907300
80MP0005375_adipose_tissue_phenotype1.08024862
81MP0002972_abnormal_cardiac_muscle1.05535172
82MP0000249_abnormal_blood_vessel1.04120509
83MP0003279_aneurysm1.03524188
84MP0004233_abnormal_muscle_weight1.00449232
85MP0010352_gastrointestinal_tract_polyps0.99819489
86MP0002405_respiratory_system_inflammati0.98943536
87MP0001348_abnormal_lacrimal_gland0.98735698
88MP0003436_decreased_susceptibility_to0.98343796
89MP0005620_abnormal_muscle_contractility0.98178263
90MP0001845_abnormal_inflammatory_respons0.97423760
91MP0004272_abnormal_basement_membrane0.94411413
92MP0001849_ear_inflammation0.93348601
93MP0005330_cardiomyopathy0.93035944
94MP0005387_immune_system_phenotype0.92363042
95MP0001790_abnormal_immune_system0.92363042
96MP0000703_abnormal_thymus_morphology0.91027829
97MP0009780_abnormal_chondrocyte_physiolo0.90385162
98MP0008875_abnormal_xenobiotic_pharmacok0.89299526
99MP0003186_abnormal_redox_activity0.89189891
100MP0006036_abnormal_mitochondrial_physio0.89164985
101MP0003638_abnormal_response/metabolism_0.88983324
102MP0008775_abnormal_heart_ventricle0.88889547
103MP0002168_other_aberrant_phenotype0.87810593
104MP0002896_abnormal_bone_mineralization0.87536930
105MP0002108_abnormal_muscle_morphology0.87106812
106MP0005165_increased_susceptibility_to0.86150202
107MP0004484_altered_response_of0.86011136
108MP0000767_abnormal_smooth_muscle0.85825879
109MP0001784_abnormal_fluid_regulation0.85188988
110MP0004130_abnormal_muscle_cell0.84733055
111MP0002128_abnormal_blood_circulation0.84438224
112MP0003941_abnormal_skin_development0.83938172
113MP0004145_abnormal_muscle_electrophysio0.83889197
114MP0000266_abnormal_heart_morphology0.83253911
115MP0005666_abnormal_adipose_tissue0.83190720
116MP0009764_decreased_sensitivity_to0.80986980
117MP0004782_abnormal_surfactant_physiolog0.80345855
118MP0003868_abnormal_feces_composition0.80082056
119MP0004087_abnormal_muscle_fiber0.78426512
120MP0005319_abnormal_enzyme/_coenzyme0.78406333
121MP0004036_abnormal_muscle_relaxation0.78023006
122MP0004085_abnormal_heartbeat0.77795461
123MP0000733_abnormal_muscle_development0.77720534
124MP0003567_abnormal_fetal_cardiomyocyte0.76572588
125MP0002019_abnormal_tumor_incidence0.75419583
126MP0005164_abnormal_response_to0.75171768
127MP0009763_increased_sensitivity_to0.74717556
128MP0005388_respiratory_system_phenotype0.74638873
129MP0002133_abnormal_respiratory_system0.74638873
130MP0001764_abnormal_homeostasis0.74161609
131MP0010630_abnormal_cardiac_muscle0.72960681
132MP0004510_myositis0.72932941
133MP0003448_altered_tumor_morphology0.72383574
134MP0001986_abnormal_taste_sensitivity0.72040957
135MP0009333_abnormal_splenocyte_physiolog0.71927676
136MP0005385_cardiovascular_system_phenoty0.71382133
137MP0001544_abnormal_cardiovascular_syste0.71382133
138MP0005257_abnormal_intraocular_pressure0.70988680
139MP0000598_abnormal_liver_morphology0.70720662
140MP0000759_abnormal_skeletal_muscle0.69436294
141MP0009765_abnormal_xenobiotic_induced0.69177484
142MP0009053_abnormal_anal_canal0.68813962
143MP0000015_abnormal_ear_pigmentation0.68723332
144MP0005595_abnormal_vascular_smooth0.68176877
145MP0003984_embryonic_growth_retardation0.67628624
146MP0001915_intracranial_hemorrhage0.67472367
147MP0002332_abnormal_exercise_endurance0.67233438
148MP0006138_congestive_heart_failure0.67219566
149MP0005584_abnormal_enzyme/coenzyme_acti0.66610114
150MP0001663_abnormal_digestive_system0.65803160
151MP0002088_abnormal_embryonic_growth/wei0.65240669
152MP0000467_abnormal_esophagus_morphology0.64666044
153MP0003385_abnormal_body_wall0.64651362
154MP0005508_abnormal_skeleton_morphology0.64301302
155MP0004215_abnormal_myocardial_fiber0.64291403
156MP0002086_abnormal_extraembryonic_tissu0.63614900
157MP0003221_abnormal_cardiomyocyte_apopto0.63142811
158MP0003935_abnormal_craniofacial_develop0.60685092
159MP0005187_abnormal_penis_morphology0.59184746
160MP0003045_fibrosis0.58917728
161MP0009384_cardiac_valve_regurgitation0.57997521
162MP0005197_abnormal_uvea_morphology0.55507274
163MP0002106_abnormal_muscle_physiology0.52584544
164MP0002971_abnormal_brown_adipose0.52529386
165MP0000049_abnormal_middle_ear0.52469198
166MP0005369_muscle_phenotype0.52265560

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.40692448
2Thrombocytosis (HP:0001894)5.82976458
3Arterial tortuosity (HP:0005116)5.31299263
4Vascular tortuosity (HP:0004948)5.11509052
5Premature rupture of membranes (HP:0001788)4.87706920
6Prolonged bleeding time (HP:0003010)4.84422630
7Abnormality of the nasal mucosa (HP:0000433)4.73068451
8Aplastic anemia (HP:0001915)4.55395041
9Cerebral aneurysm (HP:0004944)4.55121672
10Chronic otitis media (HP:0000389)4.45663330
11Esophageal varix (HP:0002040)4.31462622
12IgM deficiency (HP:0002850)4.31182519
13Abnormality of cells of the erythroid lineage (HP:0012130)4.21830661
14Aortic dissection (HP:0002647)4.20415094
15Aortic aneurysm (HP:0004942)4.14378424
16Abnormal number of erythroid precursors (HP:0012131)4.13768916
17Wrist flexion contracture (HP:0001239)4.04755910
18Abnormal platelet function (HP:0011869)3.90916037
19Impaired platelet aggregation (HP:0003540)3.90916037
20Spinal rigidity (HP:0003306)3.87661836
21Cerebral hemorrhage (HP:0001342)3.83379662
22Tetraparesis (HP:0002273)3.81488929
23Acute myeloid leukemia (HP:0004808)3.76089762
24Elevated erythrocyte sedimentation rate (HP:0003565)3.72772896
25Spontaneous hematomas (HP:0007420)3.65152282
26Petechiae (HP:0000967)3.59878015
27Myositis (HP:0100614)3.57775795
28Conjunctival telangiectasia (HP:0000524)3.53996332
29Epistaxis (HP:0000421)3.52718288
30Increased variability in muscle fiber diameter (HP:0003557)3.41338205
31Myocardial infarction (HP:0001658)3.37481142
32Acute lymphatic leukemia (HP:0006721)3.35749782
33Reticulocytopenia (HP:0001896)3.34514977
34Reduced antithrombin III activity (HP:0001976)3.32272570
35Abnormality of skeletal muscle fiber size (HP:0012084)3.32255138
36Nasal polyposis (HP:0100582)3.28228146
37Adactyly (HP:0009776)3.22319363
38Skull defect (HP:0001362)3.21125662
39Cervical subluxation (HP:0003308)3.14171261
40Microcytic anemia (HP:0001935)3.13223066
41Overgrowth (HP:0001548)3.13053966
42Abnormality of T cell physiology (HP:0011840)2.95924880
43Hematochezia (HP:0002573)2.95856540
44Lymphangioma (HP:0100764)2.90939361
45Recurrent bronchitis (HP:0002837)2.90363172
46Broad metatarsal (HP:0001783)2.90071317
47Type I transferrin isoform profile (HP:0003642)2.89251738
48Increased connective tissue (HP:0009025)2.89222021
49Type 2 muscle fiber atrophy (HP:0003554)2.87134298
50Polycythemia (HP:0001901)2.84371607
51Interstitial pulmonary disease (HP:0006530)2.84151018
52Hyporeflexia of lower limbs (HP:0002600)2.83926924
53Muscle fiber splitting (HP:0003555)2.78780871
54Muscle fiber atrophy (HP:0100295)2.78323031
55Abnormality of the vasculature of the conjunctiva (HP:0008054)2.77773535
56Nonprogressive disorder (HP:0003680)2.77728972
57Abnormality of the heme biosynthetic pathway (HP:0010472)2.74873414
58Hypoplasia of the iris (HP:0007676)2.72892909
59Soft skin (HP:0000977)2.67418752
60Nuclear cataract (HP:0100018)2.64355256
61Wormian bones (HP:0002645)2.63785038
62Hemorrhage of the eye (HP:0011885)2.60728176
63Aortic valve stenosis (HP:0001650)2.60214850
64Porencephaly (HP:0002132)2.59025628
65Stenosis of the external auditory canal (HP:0000402)2.57419295
66Mitral valve prolapse (HP:0001634)2.56650521
67Visceral angiomatosis (HP:0100761)2.55400817
68Hemangiomatosis (HP:0007461)2.47382103
69Gastrointestinal stroma tumor (HP:0100723)2.47110375
70Aneurysm (HP:0002617)2.46429106
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.46232951
72Purpura (HP:0000979)2.45649345
73Shallow orbits (HP:0000586)2.43287665
74Type 1 muscle fiber predominance (HP:0003803)2.40711882
75Ectopia lentis (HP:0001083)2.38882616
76Amaurosis fugax (HP:0100576)2.36722235
77Myotonia (HP:0002486)2.35938311
78Growth hormone excess (HP:0000845)2.33833953
79Centrally nucleated skeletal muscle fibers (HP:0003687)2.32378525
80Cardiovascular calcification (HP:0011915)2.32011644
81Gastrointestinal inflammation (HP:0004386)2.31341884
82Menorrhagia (HP:0000132)2.30738340
83Myelodysplasia (HP:0002863)2.29302778
84Absent hand (HP:0004050)2.29135474
85Pallor (HP:0000980)2.28561185
86Panhypogammaglobulinemia (HP:0003139)2.27888006
87Difficulty running (HP:0009046)2.26494244
88Blue sclerae (HP:0000592)2.26149250
89Large hands (HP:0001176)2.26096793
90Striae distensae (HP:0001065)2.26054129
91Gingival bleeding (HP:0000225)2.26017964
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25636660
93Abnormal protein N-linked glycosylation (HP:0012347)2.25636660
94Abnormal protein glycosylation (HP:0012346)2.25636660
95Abnormal glycosylation (HP:0012345)2.25636660
96Dilatation of the ascending aorta (HP:0005111)2.25219623
97Hip contracture (HP:0003273)2.24672212
98Nonimmune hydrops fetalis (HP:0001790)2.23027984
99Limited hip movement (HP:0008800)2.22379841
100Hyperlipoproteinemia (HP:0010980)2.20815593
101Nemaline bodies (HP:0003798)2.20366504
102Inflammation of the large intestine (HP:0002037)2.19849973
103Venous insufficiency (HP:0005293)2.18530160
104Weak cry (HP:0001612)2.18013117
105Pancytopenia (HP:0001876)2.16667277
106Congenital, generalized hypertrichosis (HP:0004540)2.13624863
107Colitis (HP:0002583)2.13517877
108Vertebral compression fractures (HP:0002953)2.13059760
109Cellulitis (HP:0100658)2.12615480
110Generalized aminoaciduria (HP:0002909)2.11237976
111Coxa vara (HP:0002812)2.10868524
112Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.10525950
113Erythema (HP:0010783)2.09788764
114Pulmonary hypertension (HP:0002092)2.08743189
115Abnormality of the intrinsic pathway (HP:0010989)2.08629437
116Bladder diverticulum (HP:0000015)2.07721539
117Arterial thrombosis (HP:0004420)2.06376386
118Abnormality of the prostate (HP:0008775)2.06354879
119Orchitis (HP:0100796)2.06229873
120Portal hypertension (HP:0001409)2.06045637
121Chest pain (HP:0100749)2.06022632
122Stroke (HP:0001297)2.04313878
123Acanthosis nigricans (HP:0000956)2.03399892
124Joint contractures involving the joints of the feet (HP:0100492)2.02695810
125Flexion contracture of toe (HP:0005830)2.02695810
126Distal lower limb muscle weakness (HP:0009053)2.02600624
127Ankle contracture (HP:0006466)2.02155677
128Muscle fiber inclusion bodies (HP:0100299)2.02090819
129Albinism (HP:0001022)2.02058701
130Venous abnormality (HP:0002624)2.01912388
131Abnormality of the acetabulum (HP:0003170)2.01143537
132Progressive muscle weakness (HP:0003323)2.00167315
133Esophageal neoplasm (HP:0100751)1.99009544
134Neoplasm of head and neck (HP:0012288)1.99009544
135Thrombophlebitis (HP:0004418)1.98908849
136Macrocytic anemia (HP:0001972)1.98156490
137Hypoproteinemia (HP:0003075)1.98012972
138Asymmetric septal hypertrophy (HP:0001670)1.96556268
139Follicular hyperkeratosis (HP:0007502)1.95584270
140Joint stiffness (HP:0001387)1.94953779
141Difficulty climbing stairs (HP:0003551)1.94448212
142Hemiplegia (HP:0002301)1.94195892
143Abnormal platelet volume (HP:0011876)1.93941538
144Abnormality of the fingertips (HP:0001211)1.93835710
145Lipoatrophy (HP:0100578)1.93423240
146Capillary hemangiomas (HP:0005306)1.92219232
147Recurrent viral infections (HP:0004429)1.92108455
148Abnormality of the columella (HP:0009929)1.91844303
149Asplenia (HP:0001746)1.91009278
150Mildly elevated creatine phosphokinase (HP:0008180)1.90702390
151Cavernous hemangioma (HP:0001048)1.90144235
152B lymphocytopenia (HP:0010976)1.89671443
153Abnormality of B cell number (HP:0010975)1.89671443
154Abnormality of T cells (HP:0002843)1.89132256
155Hepatic necrosis (HP:0002605)1.88570429
156Abnormality of the hepatic vasculature (HP:0006707)1.88556355
157IgG deficiency (HP:0004315)1.88411473
158Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88076769
159Mucosal telangiectasiae (HP:0100579)1.86643403
160Camptodactyly of toe (HP:0001836)1.86574134
161Patchy hypopigmentation of hair (HP:0011365)1.85988755
162Mitral stenosis (HP:0001718)1.85728460
163Hyperpituitarism (HP:0010514)1.85211860
164Chronic sinusitis (HP:0011109)1.84632537
165Pulmonary embolism (HP:0002204)1.84023413
166Bruising susceptibility (HP:0000978)1.83677941
167Joint laxity (HP:0001388)1.83333317
168Disproportionate tall stature (HP:0001519)1.82788457
169Abnormality of dentin (HP:0010299)1.82495388
170Increased IgE level (HP:0003212)1.81354178
171Osteolytic defects of the hand bones (HP:0009699)1.80713584
172Osteolytic defects of the phalanges of the hand (HP:0009771)1.80713584
173Reduced subcutaneous adipose tissue (HP:0003758)1.80486483
174Polygenic inheritance (HP:0010982)1.80405618
175Beaking of vertebral bodies (HP:0004568)1.80172176
176Vascular calcification (HP:0004934)1.79901857
177Vertebral clefting (HP:0008428)1.79282574
178Lymphopenia (HP:0001888)1.78755708
179Round ear (HP:0100830)1.78240137
180Pulmonary artery stenosis (HP:0004415)1.77799116
181Facial diplegia (HP:0001349)1.77618957
182Fatigue (HP:0012378)1.76695234
183Atrioventricular block (HP:0001678)1.76041481
184Agammaglobulinemia (HP:0004432)1.75091380
185Hepatocellular necrosis (HP:0001404)1.75007283
186Abnormality of fatty-acid metabolism (HP:0004359)1.74534480
187Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.73675747
188Hypothermia (HP:0002045)1.72284392
189Migraine (HP:0002076)1.72031981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.52334257
2KIT4.25719751
3FLT34.19898958
4KDR3.77582332
5TGFBR13.51736492
6EPHB23.13544503
7INSRR2.77992345
8TGFBR22.63875447
9FER2.46435253
10TNIK2.39800583
11TEC2.38539375
12MAP4K12.32443979
13CSF1R2.15673073
14MAP2K32.14533052
15MATK2.05858464
16BTK1.95798681
17MUSK1.93234188
18STK161.90570445
19MAP3K121.82106950
20PTK21.78830733
21EEF2K1.75337979
22NME21.69028670
23ACVR1B1.67476351
24WEE11.66509821
25NTRK11.66060406
26PTK2B1.62837464
27BCKDK1.56374427
28PDGFRA1.55508925
29MYLK1.52803747
30CDK191.50055578
31ZAP701.41332814
32IKBKE1.30813215
33JAK31.26111598
34MET1.25440884
35ADRBK21.25064499
36RPS6KB21.24992753
37PRKG21.24951592
38TTN1.22683800
39MOS1.22395232
40MKNK11.22162464
41TBK11.17740810
42LATS21.12299335
43MAPKAPK31.11322967
44PKN21.09664893
45BRSK21.06177889
46MAP3K61.04878716
47MAPKAPK51.04564269
48DYRK31.02206331
49CDK81.01313778
50PIM20.99777621
51VRK10.99143737
52PAK40.97300948
53NLK0.96582208
54MAP3K130.94393100
55PIK3CG0.91773559
56TESK10.91425964
57CSK0.91178577
58FES0.89276492
59SYK0.87495292
60LRRK20.87258750
61RIPK10.87248813
62IRAK40.86646710
63DDR20.85611333
64LIMK10.83098928
65GRK10.82716580
66PASK0.82696920
67ROCK10.81177322
68ROCK20.80600707
69ERN10.79761183
70CCNB10.79417603
71PDGFRB0.77702507
72TYK20.77404340
73CAMKK20.75715223
74PAK20.75513282
75IKBKB0.73972333
76PIM10.71698956
77EPHB10.71426679
78MKNK20.71330392
79MAP2K60.70948358
80TAOK30.70834148
81LCK0.70325870
82LYN0.68687846
83RPS6KA40.68073915
84TXK0.67007284
85HIPK20.66574731
86PRKD30.63280872
87ERBB40.60816756
88CAMK10.58931030
89PLK20.58587038
90MAPK40.56839152
91GRK50.52736052
92FGFR30.52353451
93BMPR1B0.49763602
94MAPK70.48938798
95ABL20.48340073
96DAPK10.48323097
97STK100.46149450
98PINK10.44295084
99STK390.44290970
100CHUK0.43981278
101ARAF0.43740760
102PRKD10.43580233
103ILK0.42301661
104CAMK40.42284058
105CDK70.42036654
106CDK90.41830123
107OBSCN0.41595564
108MAP3K70.41521626
109CDK60.41437378
110MAPK120.41193741
111FGFR40.40858765
112PRKCE0.40437523
113TNK20.40432833
114BLK0.40269778
115HCK0.39928844
116DMPK0.39705448
117PRKAA20.39498423
118PAK60.39035588
119ITK0.38162256
120PDK20.37015283
121MAP2K10.35971559
122TRPM70.33533407
123NEK90.33268181
124STK380.32756545
125GSK3A0.32530174
126INSR0.31982345
127SRC0.31884806
128EGFR0.31596849
129JAK10.31124228
130IRAK30.29639985
131MAP3K110.28355873
132ERBB30.28326409
133RPS6KA60.27816005
134TSSK60.27654600
135CDK40.27451473
136KSR20.27409259
137MAP3K30.27068215
138YES10.26692403
139BRD40.26535608
140EIF2AK30.25686312
141IGF1R0.25682480
142MAPK110.24606057
143JAK20.24540470
144DAPK30.23266359
145AKT20.22863970
146RPS6KA20.21730349
147MAPK30.21575144
148ADRBK10.20642510
149PTK60.18617933
150EPHA20.15764986
151PAK30.15608549
152CDC42BPA0.14688462
153KSR10.13011133
154LATS10.12969296
155EPHA30.12337768
156FGFR10.11765377
157PRKG10.09698375
158STK38L0.08823549
159PRKD20.08071549
160SGK30.08028584
161CAMK2A0.07943573

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.47742878
2ECM-receptor interaction_Homo sapiens_hsa045124.19404619
3DNA replication_Homo sapiens_hsa030304.13452098
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.07914491
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.52182327
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.46650136
7Adherens junction_Homo sapiens_hsa045202.45494582
8Mismatch repair_Homo sapiens_hsa034302.43210996
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23857295
10Dilated cardiomyopathy_Homo sapiens_hsa054142.23338574
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.22271595
12Base excision repair_Homo sapiens_hsa034102.18427452
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16879633
14Hematopoietic cell lineage_Homo sapiens_hsa046402.10545107
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.09758815
16Caffeine metabolism_Homo sapiens_hsa002322.05813618
17Complement and coagulation cascades_Homo sapiens_hsa046102.03769506
18Primary immunodeficiency_Homo sapiens_hsa053402.02254395
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97206802
20Platelet activation_Homo sapiens_hsa046111.95817198
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82390917
22Amoebiasis_Homo sapiens_hsa051461.79579675
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.77829675
24Proteoglycans in cancer_Homo sapiens_hsa052051.77213972
25Herpes simplex infection_Homo sapiens_hsa051681.66662168
26Leishmaniasis_Homo sapiens_hsa051401.64207134
27B cell receptor signaling pathway_Homo sapiens_hsa046621.62532590
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.60961993
29Measles_Homo sapiens_hsa051621.59955585
30Pyrimidine metabolism_Homo sapiens_hsa002401.57635674
31Homologous recombination_Homo sapiens_hsa034401.54087942
32Folate biosynthesis_Homo sapiens_hsa007901.53440389
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.50910171
34Acute myeloid leukemia_Homo sapiens_hsa052211.48801435
35Ras signaling pathway_Homo sapiens_hsa040141.47356232
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45010395
37Tight junction_Homo sapiens_hsa045301.43869041
38Nucleotide excision repair_Homo sapiens_hsa034201.42414852
39Axon guidance_Homo sapiens_hsa043601.41505849
40TGF-beta signaling pathway_Homo sapiens_hsa043501.40253803
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39897978
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.38360217
43Prion diseases_Homo sapiens_hsa050201.37385714
44Protein digestion and absorption_Homo sapiens_hsa049741.33776519
45Spliceosome_Homo sapiens_hsa030401.27110654
46ABC transporters_Homo sapiens_hsa020101.26895973
47RNA degradation_Homo sapiens_hsa030181.25413395
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.24872792
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.23178774
50Antigen processing and presentation_Homo sapiens_hsa046121.21992313
51Thyroid cancer_Homo sapiens_hsa052161.21580748
52Malaria_Homo sapiens_hsa051441.21288012
53RNA polymerase_Homo sapiens_hsa030201.19621374
54Dorso-ventral axis formation_Homo sapiens_hsa043201.18315498
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.17702499
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.14590912
57Purine metabolism_Homo sapiens_hsa002301.14147899
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13577323
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07032567
60Non-homologous end-joining_Homo sapiens_hsa034501.04676466
61Fatty acid degradation_Homo sapiens_hsa000711.02984799
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02950225
63N-Glycan biosynthesis_Homo sapiens_hsa005101.02770007
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01594223
65Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01371818
66Protein export_Homo sapiens_hsa030600.99500295
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99296291
68Shigellosis_Homo sapiens_hsa051310.99083586
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98795618
70VEGF signaling pathway_Homo sapiens_hsa043700.98416764
71Bladder cancer_Homo sapiens_hsa052190.97265983
72Pertussis_Homo sapiens_hsa051330.95313415
73African trypanosomiasis_Homo sapiens_hsa051430.94325416
74Legionellosis_Homo sapiens_hsa051340.92727800
75Osteoclast differentiation_Homo sapiens_hsa043800.92630438
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92417515
77Sulfur relay system_Homo sapiens_hsa041220.90046661
78MicroRNAs in cancer_Homo sapiens_hsa052060.89828808
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88221476
80Pentose phosphate pathway_Homo sapiens_hsa000300.87891094
81Hippo signaling pathway_Homo sapiens_hsa043900.85832973
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84256218
83Influenza A_Homo sapiens_hsa051640.83907930
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83799184
85Toxoplasmosis_Homo sapiens_hsa051450.83455464
86Allograft rejection_Homo sapiens_hsa053300.81902654
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80220062
88Gap junction_Homo sapiens_hsa045400.79719389
89Endocytosis_Homo sapiens_hsa041440.78221004
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78034953
91Renin secretion_Homo sapiens_hsa049240.77965325
92Ovarian steroidogenesis_Homo sapiens_hsa049130.77932489
93Pancreatic cancer_Homo sapiens_hsa052120.77552473
94Renin-angiotensin system_Homo sapiens_hsa046140.75972292
95Renal cell carcinoma_Homo sapiens_hsa052110.74824058
96Hepatitis B_Homo sapiens_hsa051610.73267698
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.71173943
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70653920
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69622893
100Melanogenesis_Homo sapiens_hsa049160.69321178
101Cell cycle_Homo sapiens_hsa041100.68042036
102Estrogen signaling pathway_Homo sapiens_hsa049150.66170951
103Arginine biosynthesis_Homo sapiens_hsa002200.66050385
104Notch signaling pathway_Homo sapiens_hsa043300.65315112
105TNF signaling pathway_Homo sapiens_hsa046680.64720386
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63639353
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63093601
108Propanoate metabolism_Homo sapiens_hsa006400.61489772
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59262257
110Basal cell carcinoma_Homo sapiens_hsa052170.58945427
111Vibrio cholerae infection_Homo sapiens_hsa051100.57815016
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56259241
113Hepatitis C_Homo sapiens_hsa051600.55288775
114Other glycan degradation_Homo sapiens_hsa005110.53490007
115Peroxisome_Homo sapiens_hsa041460.52920148
116HIF-1 signaling pathway_Homo sapiens_hsa040660.52640831
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50794195
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50507202
119Small cell lung cancer_Homo sapiens_hsa052220.50409546
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50340481
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49339525
122Oxytocin signaling pathway_Homo sapiens_hsa049210.48255938
123AMPK signaling pathway_Homo sapiens_hsa041520.48167780
124Hedgehog signaling pathway_Homo sapiens_hsa043400.47400174
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47263624
126Asthma_Homo sapiens_hsa053100.47134653
127Glycerolipid metabolism_Homo sapiens_hsa005610.47113187
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46959245
129Salmonella infection_Homo sapiens_hsa051320.46496229
130Galactose metabolism_Homo sapiens_hsa000520.45720943
131Fanconi anemia pathway_Homo sapiens_hsa034600.45029483
132Fatty acid elongation_Homo sapiens_hsa000620.44728657
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44375176
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.44008337
135GnRH signaling pathway_Homo sapiens_hsa049120.43911310
136cAMP signaling pathway_Homo sapiens_hsa040240.43249089
137Glioma_Homo sapiens_hsa052140.43128726
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.42985877
139Sulfur metabolism_Homo sapiens_hsa009200.42961794
140Thyroid hormone synthesis_Homo sapiens_hsa049180.41351073
141Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41023852
142Melanoma_Homo sapiens_hsa052180.39728367
143Focal adhesion_Homo sapiens_hsa045100.39684916
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39191503
145Circadian rhythm_Homo sapiens_hsa047100.38878260
146Insulin resistance_Homo sapiens_hsa049310.38672675
147HTLV-I infection_Homo sapiens_hsa051660.38395249
148Chronic myeloid leukemia_Homo sapiens_hsa052200.38316743
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.37802572
150Apoptosis_Homo sapiens_hsa042100.37397857
151PPAR signaling pathway_Homo sapiens_hsa033200.37204669
152Chemical carcinogenesis_Homo sapiens_hsa052040.36505646
153Vitamin digestion and absorption_Homo sapiens_hsa049770.35166533
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35059587
155Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34944503
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.33514758
157FoxO signaling pathway_Homo sapiens_hsa040680.33382376
1582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32891357
159Pathways in cancer_Homo sapiens_hsa052000.32156389
160Phagosome_Homo sapiens_hsa041450.31975854
161Insulin signaling pathway_Homo sapiens_hsa049100.31314024
162Rap1 signaling pathway_Homo sapiens_hsa040150.30910476
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30683426
164Serotonergic synapse_Homo sapiens_hsa047260.30509113
165Glutamatergic synapse_Homo sapiens_hsa047240.30502478
166Neurotrophin signaling pathway_Homo sapiens_hsa047220.29972395
167Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29971797
168Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28953512
169Colorectal cancer_Homo sapiens_hsa052100.27732049
170Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27549846

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