ADH1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)9.35323324
2epoxygenase P450 pathway (GO:0019373)9.29795891
3exogenous drug catabolic process (GO:0042738)9.22848013
4drug catabolic process (GO:0042737)8.93424737
5complement activation, alternative pathway (GO:0006957)8.55482793
6glyoxylate metabolic process (GO:0046487)8.44589889
7regulation of fibrinolysis (GO:0051917)8.39698118
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)8.10395932
9L-phenylalanine catabolic process (GO:0006559)8.10395932
10negative regulation of fibrinolysis (GO:0051918)7.72405595
11regulation of protein activation cascade (GO:2000257)7.67019999
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.38449445
13L-phenylalanine metabolic process (GO:0006558)7.38449445
14regulation of complement activation (GO:0030449)7.31092032
15* ethanol oxidation (GO:0006069)7.06744882
16urea metabolic process (GO:0019627)6.95957232
17peptidyl-glutamic acid carboxylation (GO:0017187)6.73450428
18protein carboxylation (GO:0018214)6.73450428
19fibrinolysis (GO:0042730)6.63839522
20nitrogen cycle metabolic process (GO:0071941)6.33764754
21oxidative demethylation (GO:0070989)6.20406278
22blood coagulation, intrinsic pathway (GO:0007597)6.11032785
23imidazole-containing compound metabolic process (GO:0052803)6.09742741
24urea cycle (GO:0000050)5.98409535
25* drug metabolic process (GO:0017144)5.98288599
26bile acid biosynthetic process (GO:0006699)5.90540497
27aromatic amino acid family catabolic process (GO:0009074)5.90513201
28serine family amino acid catabolic process (GO:0009071)5.89944770
29cellular glucuronidation (GO:0052695)5.81862778
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.66910156
31* ethanol metabolic process (GO:0006067)5.63316363
32negative regulation of sterol transport (GO:0032372)5.55598390
33negative regulation of cholesterol transport (GO:0032375)5.55598390
34uronic acid metabolic process (GO:0006063)5.53099278
35glucuronate metabolic process (GO:0019585)5.53099278
36regulation of plasminogen activation (GO:0010755)5.44851557
37regulation of triglyceride catabolic process (GO:0010896)5.40217957
38phenylpropanoid metabolic process (GO:0009698)5.38981373
39protein activation cascade (GO:0072376)5.32408710
40bile acid metabolic process (GO:0008206)5.21988831
41glycine metabolic process (GO:0006544)5.11036934
42complement activation (GO:0006956)5.08059072
43complement activation, classical pathway (GO:0006958)4.94858296
44negative regulation of blood coagulation (GO:0030195)4.87635891
45negative regulation of hemostasis (GO:1900047)4.87635891
46tyrosine metabolic process (GO:0006570)4.81259318
47bile acid and bile salt transport (GO:0015721)4.78841264
48S-adenosylmethionine metabolic process (GO:0046500)4.74195115
49opsonization (GO:0008228)4.72313549
50regulation of humoral immune response (GO:0002920)4.62518043
51alkaloid metabolic process (GO:0009820)4.58165461
52glutamate metabolic process (GO:0006536)4.57186196
53triglyceride homeostasis (GO:0070328)4.54190361
54acylglycerol homeostasis (GO:0055090)4.54190361
55acute-phase response (GO:0006953)4.50419865
56negative regulation of coagulation (GO:0050819)4.43235888
57negative regulation of protein activation cascade (GO:2000258)4.41939726
58negative regulation of wound healing (GO:0061045)4.39185803
59positive regulation of lipoprotein lipase activity (GO:0051006)4.33198340
60positive regulation of triglyceride lipase activity (GO:0061365)4.33198340
61cytolysis (GO:0019835)4.30236937
62plasma lipoprotein particle remodeling (GO:0034369)4.27688524
63protein-lipid complex remodeling (GO:0034368)4.27688524
64macromolecular complex remodeling (GO:0034367)4.27688524
65phospholipid efflux (GO:0033700)4.27279956
66killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.24506145
67disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.24506145
68positive regulation of blood coagulation (GO:0030194)4.22493891
69positive regulation of hemostasis (GO:1900048)4.22493891
70alpha-amino acid catabolic process (GO:1901606)4.21415283
71high-density lipoprotein particle remodeling (GO:0034375)4.19734139
72serine family amino acid metabolic process (GO:0009069)4.12369361
73cholesterol efflux (GO:0033344)4.11059329
74arginine metabolic process (GO:0006525)4.08445681
75amino-acid betaine metabolic process (GO:0006577)4.00881468
76indole-containing compound catabolic process (GO:0042436)3.95061884
77indolalkylamine catabolic process (GO:0046218)3.95061884
78tryptophan catabolic process (GO:0006569)3.95061884
79negative regulation of lipase activity (GO:0060192)3.92907767
80cellular ketone body metabolic process (GO:0046950)3.91139902
81positive regulation of coagulation (GO:0050820)3.87112924
82aromatic amino acid family metabolic process (GO:0009072)3.83505624
83regulation of cholesterol esterification (GO:0010872)3.82435194
84reverse cholesterol transport (GO:0043691)3.77231250
85hormone catabolic process (GO:0042447)3.77065813
86negative regulation of complement activation (GO:0045916)3.76664775
87serine family amino acid biosynthetic process (GO:0009070)3.61272512
88cellular amino acid catabolic process (GO:0009063)3.59985962
89flavonoid metabolic process (GO:0009812)3.56931256
90positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.56351508
91positive regulation of lipid catabolic process (GO:0050996)3.52327768
92intestinal cholesterol absorption (GO:0030299)3.49695385
93response to mercury ion (GO:0046689)3.48868540
94cysteine metabolic process (GO:0006534)3.47809342
95* xenobiotic metabolic process (GO:0006805)3.47318361
96acute inflammatory response (GO:0002526)3.43850685
97heme transport (GO:0015886)3.43109760
98ketone body metabolic process (GO:1902224)3.42995601
99sodium-independent organic anion transport (GO:0043252)3.41280838
100steroid catabolic process (GO:0006706)3.40284723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.12225283
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.12224112
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.94141929
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.77096212
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.51468699
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.70956473
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.42216146
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.34306831
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.80467294
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39488082
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.13115716
12HNF4A_19822575_ChIP-Seq_HepG2_Human2.05956023
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4497001
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.99309784
15HTT_18923047_ChIP-ChIP_STHdh_Human1.98834348
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95734229
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61335229
18ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42167616
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41534085
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40709356
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28594478
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.26546920
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.25572287
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.24545938
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11367446
26AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04476220
27RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01213966
28PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01133482
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00829677
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91748626
31CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91235656
32BCAT_22108803_ChIP-Seq_LS180_Human0.89067005
33IRF1_19129219_ChIP-ChIP_H3396_Human0.88132441
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87044496
35HNFA_21074721_ChIP-Seq_CACO-2_Human0.85612918
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84569398
37CBP_21632823_ChIP-Seq_H3396_Human0.82971187
38PHF8_20622853_ChIP-Seq_HELA_Human0.81559419
39AR_20517297_ChIP-Seq_VCAP_Human0.81086970
40GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76683019
41SOX2_21211035_ChIP-Seq_LN229_Human0.76189789
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75781395
43KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75603422
44LXR_22292898_ChIP-Seq_THP-1_Human0.73896333
45TP53_18474530_ChIP-ChIP_U2OS_Human0.73047021
46FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72472977
47CEBPB_22108803_ChIP-Seq_LS180_Human0.70825836
48GATA4_25053715_ChIP-Seq_YYC3_Human0.70398138
49GATA6_21074721_ChIP-Seq_CACO-2_Human0.69651658
50NFYA_21822215_ChIP-Seq_K562_Human0.69248631
51RAC3_21632823_ChIP-Seq_H3396_Human0.68635132
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68478733
53PIAS1_25552417_ChIP-Seq_VCAP_Human0.68041304
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.67740777
55FOXA1_25552417_ChIP-Seq_VCAP_Human0.67559324
56NFE2_27457419_Chip-Seq_LIVER_Mouse0.67489950
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67243099
58ETV2_25802403_ChIP-Seq_MESCs_Mouse0.64145567
59BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64068851
60* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63963367
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61996546
62SPI1_20517297_ChIP-Seq_HL60_Human0.61697937
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.61367525
64SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60840238
65CBX2_22325352_ChIP-Seq_293T-Rex_Human0.60597974
66SOX2_27498859_Chip-Seq_STOMACH_Mouse0.59516084
67P53_21459846_ChIP-Seq_SAOS-2_Human0.59413740
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.56433347
69DNAJC2_21179169_ChIP-ChIP_NT2_Human0.56022698
70MYC_19829295_ChIP-Seq_ESCs_Human0.55994858
71P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.55648219
72ETV1_20927104_ChIP-Seq_GIST48_Human0.55507155
73CDX2_20551321_ChIP-Seq_CACO-2_Human0.55011118
74ERG_20517297_ChIP-Seq_VCAP_Human0.54899827
75EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.54760818
76TAF2_19829295_ChIP-Seq_ESCs_Human0.54568851
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54408442
78EZH2_27294783_Chip-Seq_NPCs_Mouse0.54396486
79SMC4_20622854_ChIP-Seq_HELA_Human0.53978545
80SRY_22984422_ChIP-ChIP_TESTIS_Rat0.53632206
81ELF1_20517297_ChIP-Seq_JURKAT_Human0.53541355
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.53202435
83CTCF_27219007_Chip-Seq_Bcells_Human0.52863234
84E2F1_20622854_ChIP-Seq_HELA_Human0.52004158
85RAD21_21589869_ChIP-Seq_MESCs_Mouse0.51837863
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.51756410
87ESR2_21235772_ChIP-Seq_MCF-7_Human0.51306496
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.50391409
89RARG_19884340_ChIP-ChIP_MEFs_Mouse0.49762914
90MYC_19915707_ChIP-ChIP_AK7_Human0.49760656
91CTCF_20526341_ChIP-Seq_ESCs_Human0.49455356
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.49202835
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.49133558
94GATA1_22025678_ChIP-Seq_K562_Human0.49106215
95SA1_27219007_Chip-Seq_Bcells_Human0.48305302
96POU5F1_16518401_ChIP-PET_MESCs_Mouse0.48171753
97NFYB_21822215_ChIP-Seq_K562_Human0.48118732
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.47848791
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.47748619
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.47479059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.58126356
2MP0005360_urolithiasis6.68464329
3MP0005085_abnormal_gallbladder_physiolo6.29553045
4MP0008875_abnormal_xenobiotic_pharmacok6.08703702
5MP0005365_abnormal_bile_salt5.58642570
6MP0003195_calcinosis5.00899640
7MP0002138_abnormal_hepatobiliary_system4.06229623
8MP0003252_abnormal_bile_duct3.86070654
9MP0001666_abnormal_nutrient_absorption3.22150114
10MP0003868_abnormal_feces_composition3.21009637
11MP0009697_abnormal_copulation3.09503942
12MP0010329_abnormal_lipoprotein_level2.92492894
13MP0003806_abnormal_nucleotide_metabolis2.76865038
14MP0005332_abnormal_amino_acid2.38357624
15MP0003191_abnormal_cellular_cholesterol2.33884468
16MP0002876_abnormal_thyroid_physiology1.91964441
17MP0009840_abnormal_foam_cell1.89798479
18MP0010368_abnormal_lymphatic_system1.89332038
19MP0000609_abnormal_liver_physiology1.87172568
20MP0002118_abnormal_lipid_homeostasis1.69078002
21MP0001764_abnormal_homeostasis1.65953725
22MP0004019_abnormal_vitamin_homeostasis1.37295523
23MP0001661_extended_life_span1.28288373
24MP0009053_abnormal_anal_canal1.27397752
25MP0002132_abnormal_respiratory_system1.19974359
26MP0005670_abnormal_white_adipose1.15768131
27MP0003656_abnormal_erythrocyte_physiolo1.15109559
28MP0005319_abnormal_enzyme/_coenzyme1.11001413
29MP0005408_hypopigmentation1.10082416
30MP0000598_abnormal_liver_morphology1.06916783
31MP0005584_abnormal_enzyme/coenzyme_acti1.01410692
32MP0009764_decreased_sensitivity_to1.00444960
33MP0005451_abnormal_body_composition0.98662781
34MP0009643_abnormal_urine_homeostasis0.96195887
35MP0009763_increased_sensitivity_to0.91535949
36MP0002282_abnormal_trachea_morphology0.90218705
37MP0008872_abnormal_physiological_respon0.88493532
38MP0003186_abnormal_redox_activity0.85841760
39MP0000604_amyloidosis0.85783471
40MP0002971_abnormal_brown_adipose0.84394857
41MP0005376_homeostasis/metabolism_phenot0.83746563
42MP0009642_abnormal_blood_homeostasis0.82906202
43MP0008469_abnormal_protein_level0.79525939
44MP0001915_intracranial_hemorrhage0.76734004
45MP0005535_abnormal_body_temperature0.74933785
46MP0005187_abnormal_penis_morphology0.74111414
47MP0002249_abnormal_larynx_morphology0.73192230
48MP0005636_abnormal_mineral_homeostasis0.71625074
49MP0005395_other_phenotype0.69746477
50MP0003879_abnormal_hair_cell0.67994849
51MP0003690_abnormal_glial_cell0.67693048
52MP0002168_other_aberrant_phenotype0.62515513
53MP0008874_decreased_physiological_sensi0.62247068
54MP0005266_abnormal_metabolism0.61225123
55MP0003011_delayed_dark_adaptation0.61131227
56MP0004130_abnormal_muscle_cell0.61068517
57MP0004782_abnormal_surfactant_physiolog0.59868396
58MP0009785_altered_susceptibility_to0.58719122
59MP0005334_abnormal_fat_pad0.58648496
60MP0002078_abnormal_glucose_homeostasis0.58223821
61MP0005464_abnormal_platelet_physiology0.55053243
62MP0003638_abnormal_response/metabolism_0.48768504
63MP0009765_abnormal_xenobiotic_induced0.48420197
64MP0005166_decreased_susceptibility_to0.46877088
65MP0005023_abnormal_wound_healing0.46554033
66MP0003075_altered_response_to0.45309911
67MP0003705_abnormal_hypodermis_morpholog0.43559439
68MP0000249_abnormal_blood_vessel0.42418552
69MP0004883_abnormal_blood_vessel0.42365209
70MP0006036_abnormal_mitochondrial_physio0.42268465
71MP0005164_abnormal_response_to0.38013384
72MP0002332_abnormal_exercise_endurance0.37307054
73MP0000566_synostosis0.36282529
74MP0000467_abnormal_esophagus_morphology0.35921147
75MP0005448_abnormal_energy_balance0.35257192
76MP0005058_abnormal_lysosome_morphology0.35219371
77MP0002136_abnormal_kidney_physiology0.29307543
78MP0005647_abnormal_sex_gland0.27850900
79MP0003953_abnormal_hormone_level0.26490728
80MP0001545_abnormal_hematopoietic_system0.25746825
81MP0005397_hematopoietic_system_phenotyp0.25746825
82MP0001986_abnormal_taste_sensitivity0.25387292
83MP0009115_abnormal_fat_cell0.24847927
84MP0003718_maternal_effect0.23498997
85MP0001851_eye_inflammation0.23189365
86MP0001845_abnormal_inflammatory_respons0.23031787
87MP0000639_abnormal_adrenal_gland0.21658482
88MP0008873_increased_physiological_sensi0.19997971
89MP0005220_abnormal_exocrine_pancreas0.19373413
90MP0005666_abnormal_adipose_tissue0.17717346
91MP0002970_abnormal_white_adipose0.17625001
92MP0005083_abnormal_biliary_tract0.17621588
93MP0005197_abnormal_uvea_morphology0.17077283
94MP0003436_decreased_susceptibility_to0.16755304
95MP0002090_abnormal_vision0.16713822
96MP0001756_abnormal_urination0.16503238
97MP0002128_abnormal_blood_circulation0.16429502
98MP0001440_abnormal_grooming_behavior0.16194943
99MP0001881_abnormal_mammary_gland0.15515601
100MP0003959_abnormal_lean_body0.15178004

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)9.95145651
2Deep venous thrombosis (HP:0002625)9.90951411
3Prolonged partial thromboplastin time (HP:0003645)9.33429655
4Abnormality of aromatic amino acid family metabolism (HP:0004338)8.78845385
5Abnormality of complement system (HP:0005339)8.05769002
6Hypobetalipoproteinemia (HP:0003563)7.49269670
7Conjugated hyperbilirubinemia (HP:0002908)6.67674551
8Joint hemorrhage (HP:0005261)6.57240636
9Systemic lupus erythematosus (HP:0002725)6.54083019
10Hyperlipoproteinemia (HP:0010980)5.96585794
11Glomerulonephritis (HP:0000099)5.28807321
12Intrahepatic cholestasis (HP:0001406)5.09169948
13Abnormality of pyrimidine metabolism (HP:0004353)4.92010629
14Xanthomatosis (HP:0000991)4.90324383
15Recurrent gram-negative bacterial infections (HP:0005420)4.85500676
16Hypolipoproteinemia (HP:0010981)4.43671336
17Abnormality of the common coagulation pathway (HP:0010990)4.37308062
18Abnormality of the intrinsic pathway (HP:0010989)4.23820495
19Spontaneous abortion (HP:0005268)4.03492285
20Nephritis (HP:0000123)3.95220243
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.92521875
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.77988815
23Abnormality of methionine metabolism (HP:0010901)3.52571261
24Hypoalphalipoproteinemia (HP:0003233)3.48299646
25Hyperglycinemia (HP:0002154)3.42330134
26Neonatal hypoglycemia (HP:0001998)3.20298739
27Hyperammonemia (HP:0001987)3.19443630
28Delayed CNS myelination (HP:0002188)3.18111042
29Fat malabsorption (HP:0002630)3.13352333
30Fair hair (HP:0002286)3.09123496
31Generalized aminoaciduria (HP:0002909)2.93720132
32Abnormality of serine family amino acid metabolism (HP:0010894)2.92494432
33Abnormality of glycine metabolism (HP:0010895)2.92494432
34Gingival bleeding (HP:0000225)2.83787168
35Hypercholesterolemia (HP:0003124)2.82219040
36Mitral stenosis (HP:0001718)2.81844663
37Hemorrhage of the eye (HP:0011885)2.75084892
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.73379119
39Abnormality of nucleobase metabolism (HP:0010932)2.72594621
40Abnormality of serum amino acid levels (HP:0003112)2.70960226
41Epidermoid cyst (HP:0200040)2.70929103
42Osteomalacia (HP:0002749)2.68082296
43Hyperbilirubinemia (HP:0002904)2.62844980
44Vascular calcification (HP:0004934)2.62525286
45Thrombophlebitis (HP:0004418)2.59886284
46Rickets (HP:0002748)2.56119773
47Abnormality of sulfur amino acid metabolism (HP:0004339)2.52863699
48Purpura (HP:0000979)2.52436074
49Steatorrhea (HP:0002570)2.47113146
50Menorrhagia (HP:0000132)2.46620461
51Pulmonary embolism (HP:0002204)2.44388178
52Hepatocellular carcinoma (HP:0001402)2.38773936
53Hyperglycinuria (HP:0003108)2.36490228
54Cardiovascular calcification (HP:0011915)2.33525832
55Generalized hypopigmentation of hair (HP:0011358)2.17657609
56Reduced antithrombin III activity (HP:0001976)2.17106559
57Metabolic acidosis (HP:0001942)2.16766629
58Cholelithiasis (HP:0001081)2.10357305
59Abnormal gallbladder physiology (HP:0012438)2.08937007
60Cholecystitis (HP:0001082)2.08937007
61Ketosis (HP:0001946)2.08782332
62Hyperphosphaturia (HP:0003109)2.04804567
63Myocardial infarction (HP:0001658)2.03253962
64Abnormality of the Achilles tendon (HP:0005109)2.01436927
65Abnormality of monocarboxylic acid metabolism (HP:0010996)10.6304775
66Arthropathy (HP:0003040)1.98256179
67Abnormal gallbladder morphology (HP:0012437)1.96986921
68Abnormality of iron homeostasis (HP:0011031)1.96702643
69Blue irides (HP:0000635)1.93269951
70Elevated alkaline phosphatase (HP:0003155)1.90207788
71Hypochromic microcytic anemia (HP:0004840)1.90005672
72Irritability (HP:0000737)1.89366307
73Increased serum ferritin (HP:0003281)1.88080333
74Abnormality of vitamin metabolism (HP:0100508)1.84183063
75Gangrene (HP:0100758)1.82864603
76Abnormality of urine glucose concentration (HP:0011016)1.80761564
77Glycosuria (HP:0003076)1.80761564
78Bifid scrotum (HP:0000048)1.79981780
79Abnormal enzyme/coenzyme activity (HP:0012379)1.78103187
80Abnormality of transition element cation homeostasis (HP:0011030)1.75631437
81Increased mean platelet volume (HP:0011877)1.74568875
82Hypophosphatemic rickets (HP:0004912)1.73423929
83Abnormality of alkaline phosphatase activity (HP:0004379)1.72553444
84Abnormality of purine metabolism (HP:0004352)1.72028951
85Alkalosis (HP:0001948)1.71348395
86Epistaxis (HP:0000421)1.71343009
87Joint swelling (HP:0001386)1.70887197
88Atrioventricular block (HP:0001678)1.64630795
89Cerebral palsy (HP:0100021)1.63134642
90Abnormal urine phosphate concentration (HP:0012599)1.62685019
91Skin nodule (HP:0200036)1.61536530
92Poikilocytosis (HP:0004447)1.61123352
93Abnormal platelet volume (HP:0011876)1.57881541
94Lethargy (HP:0001254)1.57023495
95Reticulocytosis (HP:0001923)1.53522660
96Pancreatitis (HP:0001733)1.50516493
97Impaired platelet aggregation (HP:0003540)1.48945517
98Abnormal platelet function (HP:0011869)1.48945517
99Neonatal onset (HP:0003623)1.48679848
100Cerebral edema (HP:0002181)1.47061259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.16584044
2FGFR44.36522455
3TRIB33.49541078
4SIK13.34372645
5BCKDK3.08090946
6TYK22.81963141
7RIPK12.80695221
8PIK3CA2.51043786
9PIK3CG2.48472692
10PRKACG2.41552923
11PRPF4B2.20566377
12PRKAA21.95053533
13MAP2K41.87696774
14MAPK111.82029821
15NTRK31.81719724
16PRKCG1.64221324
17EPHA31.57551385
18FGFR31.51888378
19PINK11.44750643
20LATS11.44400162
21IGF1R1.41540992
22TAOK31.40983430
23ABL21.40039154
24MST1R1.37085276
25JAK11.26722945
26TNK21.21652351
27MAP3K31.20357974
28TBK11.19278396
29NEK91.16712503
30CSF1R1.15667622
31PRKG11.15475455
32ERBB21.15048038
33PKN21.14638985
34TIE11.13386973
35PDPK11.13251769
36NLK1.11755384
37PRKCZ1.06217438
38MYLK1.05937070
39JAK21.05127049
40EPHA41.04582858
41PRKACA0.97670116
42MAPK70.96191978
43PDK20.94014001
44CDK60.92225426
45CAMKK20.91418942
46KDR0.86917336
47MAPK120.86723590
48PRKAA10.82641481
49TGFBR20.81413224
50FER0.74443722
51DYRK1B0.73794880
52AKT30.70785940
53RET0.70740364
54PDK10.70012211
55MAP3K10.69889046
56BRSK20.67718097
57MAP3K20.67616429
58KIT0.66885506
59CSNK1D0.65863813
60FGFR20.65106631
61RPS6KA30.64662881
62MAPK40.63330505
63PRKCA0.63240700
64BLK0.62751012
65CAMKK10.62301767
66ZAP700.62175312
67PRKCB0.62057115
68INSRR0.61074502
69SGK4940.60987182
70SGK2230.60987182
71TAOK20.59339789
72ICK0.56959862
73SGK10.56430623
74MAP3K110.56176610
75DAPK20.54734655
76SRC0.52365751
77MET0.51806641
78GSK3A0.51407794
79MAP3K60.51175801
80PTK60.49254918
81PRKACB0.49173634
82EPHB10.48323409
83SGK20.47006090
84CDK40.46979547
85STK380.45198470
86CAMK1D0.45055802
87IKBKE0.44034758
88CAMK2G0.43361680
89SGK30.42129882
90CSNK2A10.41405173
91CSNK1E0.40769584
92CSNK2A20.36741154
93ARAF0.36428251
94STK160.34802954
95WNK30.34634604
96MAPK30.34323525
97CAMK40.33151999
98MTOR0.31479507
99MAP2K20.31364242
100CSNK1A10.30782237

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.53417778
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.22739442
3Complement and coagulation cascades_Homo sapiens_hsa046103.96480000
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.94531538
5* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.43791448
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37721409
7* Retinol metabolism_Homo sapiens_hsa008303.33760201
8* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.89590014
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.89506747
10* Chemical carcinogenesis_Homo sapiens_hsa052042.85822254
11Arginine biosynthesis_Homo sapiens_hsa002202.75550960
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.60686336
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.58229137
14Phenylalanine metabolism_Homo sapiens_hsa003602.55210251
15* Fatty acid degradation_Homo sapiens_hsa000712.48545293
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.46887686
17* Tyrosine metabolism_Homo sapiens_hsa003502.33674471
18Histidine metabolism_Homo sapiens_hsa003402.23898181
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18205301
20Butanoate metabolism_Homo sapiens_hsa006501.85673288
21Tryptophan metabolism_Homo sapiens_hsa003801.81941985
22Linoleic acid metabolism_Homo sapiens_hsa005911.80096505
23Bile secretion_Homo sapiens_hsa049761.72432670
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.68018120
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56530895
26Starch and sucrose metabolism_Homo sapiens_hsa005001.50251336
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45110700
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43829722
29Staphylococcus aureus infection_Homo sapiens_hsa051501.36204702
30PPAR signaling pathway_Homo sapiens_hsa033201.35604150
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.32290825
32Prion diseases_Homo sapiens_hsa050201.30084721
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.29512794
34beta-Alanine metabolism_Homo sapiens_hsa004101.26392201
35Peroxisome_Homo sapiens_hsa041461.23336180
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20772236
37Biosynthesis of amino acids_Homo sapiens_hsa012301.17912955
38Arachidonic acid metabolism_Homo sapiens_hsa005901.12356113
39Pyruvate metabolism_Homo sapiens_hsa006201.02916853
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99960865
41Vitamin B6 metabolism_Homo sapiens_hsa007500.98454074
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98430963
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94984170
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94558019
45Arginine and proline metabolism_Homo sapiens_hsa003300.94465655
46One carbon pool by folate_Homo sapiens_hsa006700.86892265
47Carbon metabolism_Homo sapiens_hsa012000.85833109
48* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82443468
49Propanoate metabolism_Homo sapiens_hsa006400.77530567
50Fat digestion and absorption_Homo sapiens_hsa049750.70092533
51ABC transporters_Homo sapiens_hsa020100.69855497
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66399466
53Fatty acid metabolism_Homo sapiens_hsa012120.61286366
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58647290
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.57773590
56Lysine degradation_Homo sapiens_hsa003100.47479537
57Sulfur metabolism_Homo sapiens_hsa009200.46657254
58Sulfur relay system_Homo sapiens_hsa041220.42647517
59* Metabolic pathways_Homo sapiens_hsa011000.41356600
60Pertussis_Homo sapiens_hsa051330.33997850
61Glycerolipid metabolism_Homo sapiens_hsa005610.28143015
62Insulin resistance_Homo sapiens_hsa049310.23914385
63Fructose and mannose metabolism_Homo sapiens_hsa000510.23749751
64Pentose phosphate pathway_Homo sapiens_hsa000300.23716375
65Glucagon signaling pathway_Homo sapiens_hsa049220.19258368
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18408963
67Systemic lupus erythematosus_Homo sapiens_hsa053220.17292859
68Fatty acid elongation_Homo sapiens_hsa000620.13445169
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07782705
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.06050842
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.05623348
72Glutathione metabolism_Homo sapiens_hsa004800.04992296
73Vitamin digestion and absorption_Homo sapiens_hsa049770.01850467
74AMPK signaling pathway_Homo sapiens_hsa041520.01686446
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01299839
76Selenocompound metabolism_Homo sapiens_hsa004500.00089581
77FoxO signaling pathway_Homo sapiens_hsa04068-0.3010062
78Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2590714
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.2584739
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2552804
81Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2520937
82Sphingolipid metabolism_Homo sapiens_hsa00600-0.2420092
83Type II diabetes mellitus_Homo sapiens_hsa04930-0.2205211
84Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2084803
85Circadian rhythm_Homo sapiens_hsa04710-0.1976082
86Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1847879
87Insulin signaling pathway_Homo sapiens_hsa04910-0.1368742
88Nitrogen metabolism_Homo sapiens_hsa00910-0.1352540
89Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1331432
90Fatty acid biosynthesis_Homo sapiens_hsa00061-0.1081537
91Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1016421
92Steroid biosynthesis_Homo sapiens_hsa00100-0.0932538
93Renin-angiotensin system_Homo sapiens_hsa04614-0.0794507
94Other glycan degradation_Homo sapiens_hsa00511-0.0663262
95African trypanosomiasis_Homo sapiens_hsa05143-0.0656730
96Folate biosynthesis_Homo sapiens_hsa00790-0.0588857
97Mineral absorption_Homo sapiens_hsa04978-0.0559331
98Galactose metabolism_Homo sapiens_hsa00052-0.0375290
99Serotonergic synapse_Homo sapiens_hsa04726-0.0345823
100Amoebiasis_Homo sapiens_hsa05146-0.0008723

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