ADH1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.74727618
2complement activation, alternative pathway (GO:0006957)7.19072022
3drug catabolic process (GO:0042737)7.06892573
4epoxygenase P450 pathway (GO:0019373)6.82297366
5omega-hydroxylase P450 pathway (GO:0097267)6.80981142
6* ethanol oxidation (GO:0006069)6.77065006
7regulation of protein activation cascade (GO:2000257)6.36566452
8regulation of complement activation (GO:0030449)6.14471255
9regulation of fibrinolysis (GO:0051917)6.12414534
10negative regulation of fibrinolysis (GO:0051918)6.07262602
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.89907960
12L-phenylalanine catabolic process (GO:0006559)5.89907960
13glyoxylate metabolic process (GO:0046487)5.65321901
14L-phenylalanine metabolic process (GO:0006558)5.43929803
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.43929803
16urea metabolic process (GO:0019627)5.40650378
17* ethanol metabolic process (GO:0006067)5.27845512
18drug metabolic process (GO:0017144)5.12759777
19protein carboxylation (GO:0018214)5.11421400
20peptidyl-glutamic acid carboxylation (GO:0017187)5.11421400
21blood coagulation, intrinsic pathway (GO:0007597)5.09874048
22fibrinolysis (GO:0042730)5.05175068
23nitrogen cycle metabolic process (GO:0071941)5.00919120
24regulation of triglyceride catabolic process (GO:0010896)4.81818671
25cellular glucuronidation (GO:0052695)4.69817371
26triglyceride catabolic process (GO:0019433)4.65719679
27urea cycle (GO:0000050)4.58095836
28protein activation cascade (GO:0072376)4.52802072
29bile acid biosynthetic process (GO:0006699)4.50454485
30complement activation (GO:0006956)4.45836798
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.44430511
32glucuronate metabolic process (GO:0019585)4.41836565
33uronic acid metabolic process (GO:0006063)4.41836565
34negative regulation of protein activation cascade (GO:2000258)4.40095095
35regulation of plasminogen activation (GO:0010755)4.39237731
36triglyceride homeostasis (GO:0070328)4.37774809
37acylglycerol homeostasis (GO:0055090)4.37774809
38bile acid metabolic process (GO:0008206)4.34366119
39complement activation, classical pathway (GO:0006958)4.31448518
40neutral lipid catabolic process (GO:0046461)4.30644412
41acylglycerol catabolic process (GO:0046464)4.30644412
42oxidative demethylation (GO:0070989)4.27839929
43positive regulation of lipoprotein lipase activity (GO:0051006)4.26611017
44positive regulation of triglyceride lipase activity (GO:0061365)4.26611017
45aromatic amino acid family catabolic process (GO:0009074)4.13418922
46negative regulation of hemostasis (GO:1900047)4.06988033
47negative regulation of blood coagulation (GO:0030195)4.06988033
48negative regulation of complement activation (GO:0045916)3.98767430
49low-density lipoprotein particle clearance (GO:0034383)3.97787564
50serine family amino acid catabolic process (GO:0009071)3.91617700
51plasma lipoprotein particle clearance (GO:0034381)3.87821008
52negative regulation of cholesterol transport (GO:0032375)3.87680312
53negative regulation of sterol transport (GO:0032372)3.87680312
54phenylpropanoid metabolic process (GO:0009698)3.85253227
55primary alcohol catabolic process (GO:0034310)3.84513689
56acute-phase response (GO:0006953)3.81009986
57amino-acid betaine metabolic process (GO:0006577)3.80424304
58regulation of humoral immune response (GO:0002920)3.75825308
59negative regulation of coagulation (GO:0050819)3.73782058
60bile acid and bile salt transport (GO:0015721)3.73239417
61S-adenosylmethionine metabolic process (GO:0046500)3.64952311
62negative regulation of wound healing (GO:0061045)3.62191852
63response to mercury ion (GO:0046689)3.60370863
64regulation of sequestering of triglyceride (GO:0010889)3.59810600
65daunorubicin metabolic process (GO:0044597)3.55960998
66polyketide metabolic process (GO:0030638)3.55960998
67doxorubicin metabolic process (GO:0044598)3.55960998
68positive regulation of blood coagulation (GO:0030194)3.48949121
69positive regulation of hemostasis (GO:1900048)3.48949121
70opsonization (GO:0008228)3.48845420
71* primary alcohol metabolic process (GO:0034308)3.47062395
72glycine metabolic process (GO:0006544)3.45057500
73protein-lipid complex remodeling (GO:0034368)3.40975687
74macromolecular complex remodeling (GO:0034367)3.40975687
75plasma lipoprotein particle remodeling (GO:0034369)3.40975687
76positive regulation of lipid catabolic process (GO:0050996)3.40792736
77tyrosine metabolic process (GO:0006570)3.39120946
78phospholipid homeostasis (GO:0055091)3.37731715
79negative regulation of lipase activity (GO:0060192)3.37041136
80oxaloacetate metabolic process (GO:0006107)3.34889600
81hormone catabolic process (GO:0042447)3.33167490
82fat-soluble vitamin biosynthetic process (GO:0042362)3.28785038
83fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.25845012
84regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.22326212
85positive regulation of coagulation (GO:0050820)3.19881600
86alkaloid metabolic process (GO:0009820)3.19609865
87fatty acid homeostasis (GO:0055089)3.17305056
88aminoglycoside antibiotic metabolic process (GO:0030647)3.16616032
89imidazole-containing compound metabolic process (GO:0052803)3.15222385
90regulation of cholesterol esterification (GO:0010872)3.13357580
91phospholipid efflux (GO:0033700)3.10968306
92cytolysis (GO:0019835)3.09100640
93negative regulation of humoral immune response (GO:0002921)3.08651579
94arginine metabolic process (GO:0006525)3.03568661
95glycerolipid catabolic process (GO:0046503)3.02385988
96NADH metabolic process (GO:0006734)3.02358392
97regulation of cholesterol transport (GO:0032374)3.02192676
98regulation of sterol transport (GO:0032371)3.02192676
99diacylglycerol metabolic process (GO:0046339)3.00642215
100intestinal cholesterol absorption (GO:0030299)2.98315876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.34218742
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.33461395
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.99636750
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.38270085
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.34952707
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.17900822
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.13538877
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.08909494
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.67673540
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.57216792
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51080776
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.35791410
13CLOCK_20551151_ChIP-Seq_293T_Human2.09153950
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78732397
15BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.67405740
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66327860
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.60048081
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59195810
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58952162
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57838905
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53626278
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53320303
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.49107699
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.46535925
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35950658
26PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.28095439
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27946284
28HNF4A_19822575_ChIP-Seq_HepG2_Human1.27675955
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.26489356
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.26100797
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.23555838
32TBX20_22328084_ChIP-Seq_HEART_Mouse1.21006727
33TBX20_22080862_ChIP-Seq_HEART_Mouse1.21006727
34GATA1_22025678_ChIP-Seq_K562_Human1.18190404
35* CJUN_26792858_Chip-Seq_BT549_Human1.12178077
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.10843044
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06518938
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06518938
39NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05321784
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04626836
41SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99526221
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99050268
43PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98549627
44SMAD_19615063_ChIP-ChIP_OVARY_Human0.97947101
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95717400
46BCAT_22108803_ChIP-Seq_LS180_Human0.95434521
47ESR1_21235772_ChIP-Seq_MCF-7_Human0.95241487
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94596090
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93902089
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93760059
51PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.93166854
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91577372
53CDX2_20551321_ChIP-Seq_CACO-2_Human0.91037653
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90315682
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89117505
56PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88236243
57CBP_21632823_ChIP-Seq_H3396_Human0.87340965
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87196542
59SOX2_20726797_ChIP-Seq_SW620_Human0.86322166
60TCF4_18268006_ChIP-ChIP_LS174T_Human0.85498057
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84540286
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81463990
63MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81209364
64RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80223586
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.79644017
66SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77777804
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76576560
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.76496362
69SOX2_27498859_Chip-Seq_STOMACH_Mouse0.75197357
70EZH2_18974828_ChIP-Seq_MESCs_Mouse0.74676243
71RNF2_18974828_ChIP-Seq_MESCs_Mouse0.74676243
72ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74104009
73GATA4_25053715_ChIP-Seq_YYC3_Human0.73930243
74TP53_18474530_ChIP-ChIP_U2OS_Human0.73928985
75FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73559027
76FOXO3_23340844_ChIP-Seq_DLD1_Human0.72972344
77HTT_18923047_ChIP-ChIP_STHdh_Human0.72439252
78DNAJC2_21179169_ChIP-ChIP_NT2_Human0.71508188
79EED_16625203_ChIP-ChIP_MESCs_Mouse0.71362513
80BP1_19119308_ChIP-ChIP_Hs578T_Human0.70573429
81LXR_22292898_ChIP-Seq_THP-1_Human0.69830098
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.68438772
83SA1_22415368_ChIP-Seq_MEFs_Mouse0.67226530
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.65884355
85NR3C1_23031785_ChIP-Seq_PC12_Mouse0.65841479
86FOXA1_25552417_ChIP-Seq_VCAP_Human0.63267782
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.62837815
88P63_26484246_Chip-Seq_KERATINOCYTES_Human0.62246627
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.61898444
90SMC3_22415368_ChIP-Seq_MEFs_Mouse0.61796473
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.61698722
92WT1_25993318_ChIP-Seq_PODOCYTE_Human0.61305715
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.60816870
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.60712812
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.60615570
96ERG_21242973_ChIP-ChIP_JURKAT_Human0.59667188
97SMC1_22415368_ChIP-Seq_MEFs_Mouse0.59415145
98AHR_22903824_ChIP-Seq_MCF-7_Human0.59137342
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59032087
100TP63_17297297_ChIP-ChIP_HaCaT_Human0.58418814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.00104124
2MP0005670_abnormal_white_adipose4.51976229
3MP0005365_abnormal_bile_salt4.38028331
4MP0005085_abnormal_gallbladder_physiolo4.24794526
5MP0005360_urolithiasis4.19394404
6MP0008875_abnormal_xenobiotic_pharmacok3.74336261
7MP0003868_abnormal_feces_composition3.02112189
8MP0010329_abnormal_lipoprotein_level3.00982520
9MP0008438_abnormal_cutaneous_collagen2.92710457
10MP0003195_calcinosis2.78889120
11MP0002138_abnormal_hepatobiliary_system2.70764197
12MP0010368_abnormal_lymphatic_system2.70629602
13MP0003252_abnormal_bile_duct2.66207586
14MP0005666_abnormal_adipose_tissue2.58575367
15MP0004130_abnormal_muscle_cell2.45419874
16MP0002971_abnormal_brown_adipose2.45272646
17MP0003191_abnormal_cellular_cholesterol2.41941539
18MP0005275_abnormal_skin_tensile2.33949196
19MP0002876_abnormal_thyroid_physiology2.18853318
20MP0001666_abnormal_nutrient_absorption2.07105248
21MP0005503_abnormal_tendon_morphology2.03159974
22MP0001661_extended_life_span2.01204432
23MP0002118_abnormal_lipid_homeostasis1.96569619
24MP0005375_adipose_tissue_phenotype1.84485192
25MP0005332_abnormal_amino_acid1.78197295
26MP0003705_abnormal_hypodermis_morpholog1.77614581
27MP0004272_abnormal_basement_membrane1.76584111
28MP0001958_emphysema1.71337360
29MP0009840_abnormal_foam_cell1.60523788
30MP0000609_abnormal_liver_physiology1.58632939
31MP0009115_abnormal_fat_cell1.51322034
32MP0004782_abnormal_surfactant_physiolog1.48139403
33MP0005535_abnormal_body_temperature1.41014175
34MP0005334_abnormal_fat_pad1.39621211
35MP0006138_congestive_heart_failure1.37155349
36MP0003724_increased_susceptibility_to1.33853018
37MP0004185_abnormal_adipocyte_glucose1.27633863
38MP0003690_abnormal_glial_cell1.27212326
39MP0003011_delayed_dark_adaptation1.26862364
40MP0003959_abnormal_lean_body1.25516280
41MP0003186_abnormal_redox_activity1.23361579
42MP0000751_myopathy1.21866263
43MP0001764_abnormal_homeostasis1.19159951
44MP0009697_abnormal_copulation1.18503746
45MP0002295_abnormal_pulmonary_circulatio1.14995727
46MP0002970_abnormal_white_adipose1.13925143
47MP0005164_abnormal_response_to1.10549479
48MP0005584_abnormal_enzyme/coenzyme_acti1.09454185
49MP0003806_abnormal_nucleotide_metabolis1.03993924
50MP0003828_pulmonary_edema1.02644633
51MP0005595_abnormal_vascular_smooth1.01219996
52MP0000249_abnormal_blood_vessel0.99281362
53MP0003279_aneurysm0.98392154
54MP0009643_abnormal_urine_homeostasis0.98257971
55MP0004019_abnormal_vitamin_homeostasis0.97100281
56MP0000003_abnormal_adipose_tissue0.95884542
57MP0005023_abnormal_wound_healing0.95552268
58MP0005448_abnormal_energy_balance0.95200660
59MP0002108_abnormal_muscle_morphology0.93931972
60MP0009780_abnormal_chondrocyte_physiolo0.91850124
61MP0005319_abnormal_enzyme/_coenzyme0.84970124
62MP0002078_abnormal_glucose_homeostasis0.83871394
63MP0004883_abnormal_blood_vessel0.82789900
64MP0001879_abnormal_lymphatic_vessel0.80576209
65MP0005647_abnormal_sex_gland0.80367843
66MP0000343_altered_response_to0.78252491
67MP0003950_abnormal_plasma_membrane0.77629239
68MP0009763_increased_sensitivity_to0.76587834
69MP0000598_abnormal_liver_morphology0.76530237
70MP0005385_cardiovascular_system_phenoty0.76209581
71MP0001544_abnormal_cardiovascular_syste0.76209581
72MP0005167_abnormal_blood-brain_barrier0.75550933
73MP0000013_abnormal_adipose_tissue0.74781659
74MP0005376_homeostasis/metabolism_phenot0.73858825
75MP0002933_joint_inflammation0.73621611
76MP0002133_abnormal_respiratory_system0.73418391
77MP0005388_respiratory_system_phenotype0.73418391
78MP0000767_abnormal_smooth_muscle0.69559802
79MP0000604_amyloidosis0.65196862
80MP0009642_abnormal_blood_homeostasis0.64755659
81MP0002132_abnormal_respiratory_system0.63457695
82MP0003566_abnormal_cell_adhesion0.61493804
83MP0003879_abnormal_hair_cell0.60187796
84MP0002128_abnormal_blood_circulation0.60034187
85MP0001851_eye_inflammation0.58606244
86MP0002249_abnormal_larynx_morphology0.58381974
87MP0001915_intracranial_hemorrhage0.57208323
88MP0009764_decreased_sensitivity_to0.57080365
89MP0005452_abnormal_adipose_tissue0.56154163
90MP0003075_altered_response_to0.54081665
91MP0006036_abnormal_mitochondrial_physio0.52706259
92MP0002060_abnormal_skin_morphology0.51850159
93MP0003091_abnormal_cell_migration0.50021235
94MP0008469_abnormal_protein_level0.49703041
95MP0001533_abnormal_skeleton_physiology0.49681143
96MP0009053_abnormal_anal_canal0.49584200
97MP0000230_abnormal_systemic_arterial0.48749632
98MP0003638_abnormal_response/metabolism_0.48139652
99MP0004087_abnormal_muscle_fiber0.48108102
100MP0008775_abnormal_heart_ventricle0.47767837

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)9.73953902
2Abnormality of complement system (HP:0005339)8.21841101
3Abnormality of monocarboxylic acid metabolism (HP:0010996)8.19445200
4Deep venous thrombosis (HP:0002625)7.19008754
5Systemic lupus erythematosus (HP:0002725)6.79798711
6Prolonged partial thromboplastin time (HP:0003645)6.35759226
7Abnormality of aromatic amino acid family metabolism (HP:0004338)6.26031238
8Hyperlipoproteinemia (HP:0010980)5.46030077
9Joint hemorrhage (HP:0005261)5.23812995
10Hypobetalipoproteinemia (HP:0003563)5.10141299
11Conjugated hyperbilirubinemia (HP:0002908)5.03270352
12Glomerulonephritis (HP:0000099)5.02055212
13Xanthomatosis (HP:0000991)4.42440888
14Nephritis (HP:0000123)4.09168667
15Intrahepatic cholestasis (HP:0001406)3.92987017
16Recurrent gram-negative bacterial infections (HP:0005420)3.86813317
17Abnormality of the common coagulation pathway (HP:0010990)3.62400071
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.55129810
19Hypolipoproteinemia (HP:0010981)3.53931775
20Abnormality of the intrinsic pathway (HP:0010989)3.52073965
21Hemorrhage of the eye (HP:0011885)3.25593405
22Oligomenorrhea (HP:0000876)3.25551061
23Spontaneous abortion (HP:0005268)3.13655781
24Protrusio acetabuli (HP:0003179)3.12570780
25Hypoalphalipoproteinemia (HP:0003233)3.06748200
26Fat malabsorption (HP:0002630)3.05297312
27Hypertriglyceridemia (HP:0002155)3.02719853
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.02345790
29Abnormality of pyrimidine metabolism (HP:0004353)2.95279519
30Epidermoid cyst (HP:0200040)2.93889424
31Hypercholesterolemia (HP:0003124)2.90388601
32Mitral stenosis (HP:0001718)2.89925645
33Myocardial infarction (HP:0001658)2.77695214
34Aortic aneurysm (HP:0004942)2.77011128
35Steatorrhea (HP:0002570)2.73267373
36Acanthosis nigricans (HP:0000956)2.71492804
37Skin nodule (HP:0200036)2.69866508
38Delayed CNS myelination (HP:0002188)2.63983950
39Rickets (HP:0002748)2.55152010
40Polycythemia (HP:0001901)2.43061363
41Hyperammonemia (HP:0001987)2.35798229
42Abnormality of methionine metabolism (HP:0010901)2.32617979
43Neonatal hypoglycemia (HP:0001998)2.25744439
44Increased variability in muscle fiber diameter (HP:0003557)2.24836664
45Gingival bleeding (HP:0000225)2.22814489
46Cardiovascular calcification (HP:0011915)2.15559805
47Amyloidosis (HP:0011034)2.14267620
48Generalized aminoaciduria (HP:0002909)2.10161895
49Purpura (HP:0000979)2.09306982
50Vascular calcification (HP:0004934)2.09139067
51Vascular tortuosity (HP:0004948)2.07125554
52Atrioventricular block (HP:0001678)2.05266580
53Hyperglycinemia (HP:0002154)2.04283420
54Abnormality of serine family amino acid metabolism (HP:0010894)1.95653500
55Abnormality of glycine metabolism (HP:0010895)1.95653500
56Thrombophlebitis (HP:0004418)1.94027807
57Striae distensae (HP:0001065)1.93911758
58Esophageal varix (HP:0002040)1.92437086
59Lymphangioma (HP:0100764)1.92395955
60Broad metatarsal (HP:0001783)1.91311776
61Abnormality of nucleobase metabolism (HP:0010932)1.90168581
62Vertebral compression fractures (HP:0002953)1.90068961
63Back pain (HP:0003418)1.88489761
64Increased connective tissue (HP:0009025)1.87735520
65Pulmonary embolism (HP:0002204)1.83768407
66Increased mean platelet volume (HP:0011877)1.83497013
67Abnormality of skeletal muscle fiber size (HP:0012084)1.82900335
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82874874
69Osteomalacia (HP:0002749)1.82620109
70Aortic dissection (HP:0002647)1.80827036
71Insulin resistance (HP:0000855)1.78223946
72Abnormality of vitamin metabolism (HP:0100508)1.77889660
73Pigmentary retinal degeneration (HP:0001146)1.77575724
74Wrist flexion contracture (HP:0001239)1.76968083
75Hyperglycinuria (HP:0003108)1.74401750
76Abnormality of serum amino acid levels (HP:0003112)1.73988953
77Menorrhagia (HP:0000132)1.73431905
78Potter facies (HP:0002009)1.69761420
79Facial shape deformation (HP:0011334)1.69761420
80Abnormality of sulfur amino acid metabolism (HP:0004339)1.66485482
81Abnormal delivery (HP:0001787)1.66370510
82Stroke (HP:0001297)1.65830319
83Abnormality of proline metabolism (HP:0010907)1.61995091
84Hydroxyprolinuria (HP:0003080)1.61995091
85Hepatocellular carcinoma (HP:0001402)1.61877904
86Hyperbilirubinemia (HP:0002904)1.61423908
87Abnormal platelet volume (HP:0011876)1.61016940
88Fair hair (HP:0002286)1.60251943
89Interstitial pulmonary disease (HP:0006530)1.58785235
90Spontaneous hematomas (HP:0007420)1.58588260
91Cerebral aneurysm (HP:0004944)1.57923441
92Visceral angiomatosis (HP:0100761)1.57591365
93Arterial tortuosity (HP:0005116)1.57517696
94Muscle fiber splitting (HP:0003555)1.56787190
95Aneurysm (HP:0002617)1.56016638
96Neonatal onset (HP:0003623)1.55441739
97Cerebral palsy (HP:0100021)1.54618655
98Abnormality of the Achilles tendon (HP:0005109)1.50229652
99Spinal rigidity (HP:0003306)1.48686480
100Premature rupture of membranes (HP:0001788)1.48134924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK3.50134409
2RIPK13.47970266
3TIE13.39462076
4ERN13.37349500
5TGFBR22.94923795
6TRIB32.88078450
7DDR22.57932139
8EPHA32.49119959
9PDGFRA2.41888866
10SIK12.27874092
11FGFR42.20016694
12PRKAA22.13433469
13EPHB22.11744417
14LATS12.02597495
15NEK91.89500210
16MAP3K61.77720885
17TYK21.57856065
18EPHB11.56326301
19ABL21.53991310
20NLK1.53873335
21GRK51.43770636
22LATS21.43220450
23PRPF4B1.39621055
24KIT1.37045551
25JAK11.33355881
26PRKACG1.17995905
27MAPKAPK31.17845576
28EEF2K1.17067306
29MAPK41.16555492
30PIK3CG1.15773099
31MAPK71.15753882
32MAPK121.14192290
33PDGFRB1.13636774
34FER1.13222870
35CDC42BPA1.12449519
36TRPM71.11359132
37PDPK11.09492978
38TESK11.07944526
39PIK3CA1.07749236
40FGFR31.07332695
41GRK11.05338849
42STK38L1.00703096
43PINK10.96809096
44MAP3K130.96543686
45AKT30.92324914
46KDR0.90456070
47JAK20.90362163
48CAMK10.88704721
49PAK20.87288432
50TTN0.86995611
51PRKAA10.85159655
52CDK60.84589230
53CAMKK20.83896382
54MAP3K70.82002884
55IGF1R0.80396571
56GSK3A0.78457235
57PRKG10.76022492
58RET0.75782781
59ADRBK10.73052508
60PRKD10.70919757
61CSK0.70581357
62TBK10.68894796
63MAP3K30.68601045
64MAPK110.60735682
65MAP2K40.60330354
66MAP3K10.59022832
67SGK20.58675978
68STK380.57720911
69MAP2K10.57205535
70ZAP700.56826476
71SGK4940.56716381
72SGK2230.56716381
73MTOR0.54847240
74SGK30.50974336
75DAPK20.50480255
76MET0.49193702
77OBSCN0.49168858
78RPS6KA20.49135003
79MARK20.47192021
80CAMK1D0.46811770
81MAPK150.46688633
82PTK20.46529684
83PKN20.46150779
84MOS0.46075141
85MAPK30.44586628
86PRKACA0.43961521
87NTRK10.43925447
88SRC0.42904024
89PDK10.39819285
90LMTK20.39488182
91KSR20.39461074
92JAK30.39083790
93MST1R0.38866422
94ARAF0.38747662
95PRKACB0.38668867
96DAPK30.38510322
97FGFR20.38281113
98DMPK0.38126564
99PTK60.37380328
100RPS6KA30.37149444

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.01819263
2Complement and coagulation cascades_Homo sapiens_hsa046103.77924052
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.49714686
4* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.28518570
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.23595791
6* Retinol metabolism_Homo sapiens_hsa008303.12570667
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10334792
8Phenylalanine metabolism_Homo sapiens_hsa003602.98293502
9* Fatty acid degradation_Homo sapiens_hsa000712.70683935
10* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.62392753
11* Chemical carcinogenesis_Homo sapiens_hsa052042.61541482
12* Tyrosine metabolism_Homo sapiens_hsa003502.41838945
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37502468
14Histidine metabolism_Homo sapiens_hsa003402.35690034
15PPAR signaling pathway_Homo sapiens_hsa033202.34322496
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33891203
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.33060817
18Tryptophan metabolism_Homo sapiens_hsa003802.19465013
19Arginine biosynthesis_Homo sapiens_hsa002202.19273930
20Drug metabolism - other enzymes_Homo sapiens_hsa009832.14807958
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95993152
22Butanoate metabolism_Homo sapiens_hsa006501.90562902
23Bile secretion_Homo sapiens_hsa049761.69316613
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67570890
25beta-Alanine metabolism_Homo sapiens_hsa004101.66691889
26Linoleic acid metabolism_Homo sapiens_hsa005911.64073342
27Staphylococcus aureus infection_Homo sapiens_hsa051501.50065929
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46049680
29Pyruvate metabolism_Homo sapiens_hsa006201.42981962
30Starch and sucrose metabolism_Homo sapiens_hsa005001.34513533
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.32784111
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29300651
33Propanoate metabolism_Homo sapiens_hsa006401.26594766
34Vitamin B6 metabolism_Homo sapiens_hsa007501.19784406
35Prion diseases_Homo sapiens_hsa050201.18015072
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14321812
37Peroxisome_Homo sapiens_hsa041461.11677470
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10528941
39Fat digestion and absorption_Homo sapiens_hsa049751.09032311
40Arachidonic acid metabolism_Homo sapiens_hsa005901.08559206
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07460969
42Fatty acid metabolism_Homo sapiens_hsa012121.05458849
43Glycerolipid metabolism_Homo sapiens_hsa005611.01391655
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98595457
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95356507
46ABC transporters_Homo sapiens_hsa020100.94471254
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88416192
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85500675
49Arginine and proline metabolism_Homo sapiens_hsa003300.83518384
50Carbon metabolism_Homo sapiens_hsa012000.77765511
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.72631144
52Fatty acid biosynthesis_Homo sapiens_hsa000610.68833509
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.66822869
54Biosynthesis of amino acids_Homo sapiens_hsa012300.65761201
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65151623
56* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64309250
57Pertussis_Homo sapiens_hsa051330.60095875
58Lysine degradation_Homo sapiens_hsa003100.55429549
59ECM-receptor interaction_Homo sapiens_hsa045120.51697847
60Fatty acid elongation_Homo sapiens_hsa000620.49658691
61Insulin resistance_Homo sapiens_hsa049310.49488417
62AMPK signaling pathway_Homo sapiens_hsa041520.47399521
63Sulfur metabolism_Homo sapiens_hsa009200.46142943
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41172965
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.39189408
66Sulfur relay system_Homo sapiens_hsa041220.37037902
67One carbon pool by folate_Homo sapiens_hsa006700.29441229
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28701113
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.26552009
70Renin-angiotensin system_Homo sapiens_hsa046140.26070167
71* Metabolic pathways_Homo sapiens_hsa011000.24434904
72Amoebiasis_Homo sapiens_hsa051460.22904913
73Glucagon signaling pathway_Homo sapiens_hsa049220.21692155
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.19638317
75Ovarian steroidogenesis_Homo sapiens_hsa049130.17538098
76Insulin signaling pathway_Homo sapiens_hsa049100.16377884
77Mineral absorption_Homo sapiens_hsa049780.15685719
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14743471
79Focal adhesion_Homo sapiens_hsa045100.13990862
80Malaria_Homo sapiens_hsa051440.12695538
81Vitamin digestion and absorption_Homo sapiens_hsa049770.12541434
82Protein digestion and absorption_Homo sapiens_hsa049740.12363823
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.12236369
84Glutathione metabolism_Homo sapiens_hsa004800.12035908
85Pentose phosphate pathway_Homo sapiens_hsa000300.11290871
86Other glycan degradation_Homo sapiens_hsa005110.07793428
87Fructose and mannose metabolism_Homo sapiens_hsa000510.05793423
88Renin secretion_Homo sapiens_hsa049240.04798362
89PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0900407
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0868341
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0748131
92Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0647665
93Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0602778
94Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0551057
95Serotonergic synapse_Homo sapiens_hsa04726-0.0476231
96Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0441540
97Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0397266
98Type II diabetes mellitus_Homo sapiens_hsa04930-0.0363037
99Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0356353
100Circadian rhythm_Homo sapiens_hsa04710-0.0168657

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