ADH1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.94417714
2exogenous drug catabolic process (GO:0042738)8.31662019
3drug catabolic process (GO:0042737)8.08481017
4omega-hydroxylase P450 pathway (GO:0097267)7.72457093
5* ethanol oxidation (GO:0006069)7.63178830
6complement activation, alternative pathway (GO:0006957)7.45856239
7cellular glucuronidation (GO:0052695)6.83320577
8regulation of protein activation cascade (GO:2000257)6.67764647
9L-phenylalanine catabolic process (GO:0006559)6.56744458
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.56744458
11uronic acid metabolic process (GO:0006063)6.53177302
12glucuronate metabolic process (GO:0019585)6.53177302
13urea metabolic process (GO:0019627)6.49536896
14glyoxylate metabolic process (GO:0046487)6.43955125
15drug metabolic process (GO:0017144)6.43666632
16regulation of complement activation (GO:0030449)6.39819993
17* ethanol metabolic process (GO:0006067)6.34192859
18L-phenylalanine metabolic process (GO:0006558)6.25981318
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.25981318
20regulation of fibrinolysis (GO:0051917)6.23482524
21nitrogen cycle metabolic process (GO:0071941)5.93780988
22urea cycle (GO:0000050)5.76494911
23negative regulation of fibrinolysis (GO:0051918)5.73192981
24phenylpropanoid metabolic process (GO:0009698)5.37177436
25bile acid and bile salt transport (GO:0015721)5.34166845
26peptidyl-glutamic acid carboxylation (GO:0017187)5.28112658
27protein carboxylation (GO:0018214)5.28112658
28bile acid metabolic process (GO:0008206)5.10868326
29bile acid biosynthetic process (GO:0006699)5.07884624
30fibrinolysis (GO:0042730)5.06391627
31oxidative demethylation (GO:0070989)5.02420520
32complement activation, classical pathway (GO:0006958)4.90281726
33complement activation (GO:0006956)4.89619578
34protein activation cascade (GO:0072376)4.87482544
35regulation of triglyceride catabolic process (GO:0010896)4.84778041
36flavonoid metabolic process (GO:0009812)4.80752939
37primary alcohol catabolic process (GO:0034310)4.65365759
38blood coagulation, intrinsic pathway (GO:0007597)4.63711809
39aromatic amino acid family catabolic process (GO:0009074)4.61023214
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.59565887
41negative regulation of sterol transport (GO:0032372)4.45097707
42negative regulation of cholesterol transport (GO:0032375)4.45097707
43imidazole-containing compound metabolic process (GO:0052803)4.41850172
44alkaloid metabolic process (GO:0009820)4.26174677
45serine family amino acid catabolic process (GO:0009071)4.24696544
46hormone catabolic process (GO:0042447)4.20009019
47negative regulation of blood coagulation (GO:0030195)4.16836232
48negative regulation of hemostasis (GO:1900047)4.16836232
49acute-phase response (GO:0006953)4.14828726
50regulation of humoral immune response (GO:0002920)4.11172407
51arginine metabolic process (GO:0006525)4.06912091
52negative regulation of protein activation cascade (GO:2000258)4.02454851
53positive regulation of lipoprotein lipase activity (GO:0051006)3.96202874
54positive regulation of triglyceride lipase activity (GO:0061365)3.96202874
55glutamate metabolic process (GO:0006536)3.93986854
56regulation of plasminogen activation (GO:0010755)3.91227786
57negative regulation of coagulation (GO:0050819)3.86869427
58opsonization (GO:0008228)3.82190182
59S-adenosylmethionine metabolic process (GO:0046500)3.78943300
60tyrosine metabolic process (GO:0006570)3.78466638
61negative regulation of wound healing (GO:0061045)3.77696632
62protein-lipid complex remodeling (GO:0034368)3.77286893
63macromolecular complex remodeling (GO:0034367)3.77286893
64plasma lipoprotein particle remodeling (GO:0034369)3.77286893
65cellular ketone body metabolic process (GO:0046950)3.76372755
66positive regulation of lipid catabolic process (GO:0050996)3.73720403
67intestinal absorption (GO:0050892)3.70770480
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.70151882
69acylglycerol homeostasis (GO:0055090)3.68070689
70triglyceride homeostasis (GO:0070328)3.68070689
71amino-acid betaine metabolic process (GO:0006577)3.67476879
72* xenobiotic metabolic process (GO:0006805)3.65191801
73fat-soluble vitamin biosynthetic process (GO:0042362)3.63012135
74phospholipid efflux (GO:0033700)3.62917335
75* primary alcohol metabolic process (GO:0034308)3.61267395
76doxorubicin metabolic process (GO:0044598)3.57107982
77daunorubicin metabolic process (GO:0044597)3.57107982
78polyketide metabolic process (GO:0030638)3.57107982
79high-density lipoprotein particle remodeling (GO:0034375)3.54819913
80cytolysis (GO:0019835)3.51534532
81regulation of cholesterol esterification (GO:0010872)3.46975565
82glycine metabolic process (GO:0006544)3.46357072
83negative regulation of complement activation (GO:0045916)3.45280575
84cholesterol efflux (GO:0033344)3.42692587
85disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.42593679
86killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.42593679
87alpha-amino acid catabolic process (GO:1901606)3.31791282
88sulfur amino acid catabolic process (GO:0000098)3.30498491
89ketone body metabolic process (GO:1902224)3.28450459
90drug transmembrane transport (GO:0006855)3.27905701
91regulation of bile acid biosynthetic process (GO:0070857)3.25498348
92regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.21366794
93negative regulation of humoral immune response (GO:0002921)3.19864411
94renal system process involved in regulation of blood volume (GO:0001977)3.18431914
95renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.18030871
96arginine catabolic process (GO:0006527)3.17737934
97negative regulation of lipase activity (GO:0060192)3.17297134
98aminoglycoside antibiotic metabolic process (GO:0030647)3.16898359
99positive regulation of hemostasis (GO:1900048)3.16792796
100positive regulation of blood coagulation (GO:0030194)3.16792796

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.50485696
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.51232947
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.21369644
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.70120125
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.58019792
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.33552802
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.54420737
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.91987737
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.87739222
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.78993231
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.70116433
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04054499
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.03880750
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96217613
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.87410964
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83907651
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.81626792
18GATA4_25053715_ChIP-Seq_YYC3_Human1.77929838
19HNF4A_19822575_ChIP-Seq_HepG2_Human1.75801305
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71313141
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.63619584
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.63214347
23SOX2_20726797_ChIP-Seq_SW620_Human1.63143206
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61377573
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.60894990
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58767460
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54738986
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.53828956
29* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.51330697
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48896734
31GATA6_25053715_ChIP-Seq_YYC3_Human1.47546173
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.33430066
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.33128584
34FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.32601725
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.30945225
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30844744
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29145087
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.28034572
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23506221
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21972869
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18981863
42FOXA1_25552417_ChIP-Seq_VCAP_Human1.15357578
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14949571
44LXR_22292898_ChIP-Seq_THP-1_Human1.11612346
45HTT_18923047_ChIP-ChIP_STHdh_Human1.09493554
46BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03383541
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03133415
48DROSHA_22980978_ChIP-Seq_HELA_Human1.02064372
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01741054
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.00845265
51CEBPB_22108803_ChIP-Seq_LS180_Human1.00685984
52CLOCK_20551151_ChIP-Seq_293T_Human0.93938432
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91383599
54PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91151524
55CDX2_22108803_ChIP-Seq_LS180_Human0.90759977
56HNFA_21074721_ChIP-Seq_CACO-2_Human0.90016148
57CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89818086
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89789621
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87446856
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86723462
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86121827
62RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85292623
63GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81995493
64P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81318107
65KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81120476
66PIAS1_25552417_ChIP-Seq_VCAP_Human0.80713489
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79149386
68PHF8_20622853_ChIP-Seq_HELA_Human0.78663216
69BCAT_22108803_ChIP-Seq_LS180_Human0.77814546
70GATA3_24758297_ChIP-Seq_MCF-7_Human0.77303867
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77023148
72CTCF_27219007_Chip-Seq_Bcells_Human0.76677217
73SOX2_21211035_ChIP-Seq_LN229_Human0.76637174
74SA1_27219007_Chip-Seq_Bcells_Human0.75871937
75AR_20517297_ChIP-Seq_VCAP_Human0.74926574
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74598517
77RACK7_27058665_Chip-Seq_MCF-7_Human0.74479762
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73984210
79GATA6_21074721_ChIP-Seq_CACO-2_Human0.73693553
80KLF5_25053715_ChIP-Seq_YYC3_Human0.73640921
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73615111
82ESR1_15608294_ChIP-ChIP_MCF-7_Human0.72898984
83SMC4_20622854_ChIP-Seq_HELA_Human0.72625829
84CBP_21632823_ChIP-Seq_H3396_Human0.71821226
85NFYA_21822215_ChIP-Seq_K562_Human0.69224381
86RUNX1_27514584_Chip-Seq_MCF-7_Human0.68796348
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.68423754
88* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68067245
89E2F1_20622854_ChIP-Seq_HELA_Human0.67686482
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.66927624
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.66819786
92RXRA_24833708_ChIP-Seq_LIVER_Mouse0.66631265
93ETV1_20927104_ChIP-Seq_GIST48_Human0.66122989
94JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.64953829
95BCL6_27268052_Chip-Seq_Bcells_Human0.63594943
96CBX2_22325352_ChIP-Seq_293T-Rex_Human0.63531705
97BCOR_27268052_Chip-Seq_Bcells_Human0.63512205
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.62961676
99GATA1_19941826_ChIP-Seq_K562_Human0.62930899
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.62500804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.12695193
2MP0005360_urolithiasis6.38786073
3MP0005085_abnormal_gallbladder_physiolo6.04504388
4MP0008875_abnormal_xenobiotic_pharmacok5.60688688
5MP0005365_abnormal_bile_salt5.42501329
6MP0001666_abnormal_nutrient_absorption3.66215134
7MP0002138_abnormal_hepatobiliary_system3.66030356
8MP0003252_abnormal_bile_duct3.45917828
9MP0003195_calcinosis3.45443627
10MP0003868_abnormal_feces_composition3.06922648
11MP0010329_abnormal_lipoprotein_level2.56304472
12MP0003806_abnormal_nucleotide_metabolis2.31923493
13MP0005332_abnormal_amino_acid2.27494392
14MP0003191_abnormal_cellular_cholesterol2.11179845
15MP0004019_abnormal_vitamin_homeostasis2.06485572
16MP0002876_abnormal_thyroid_physiology1.99076718
17MP0009840_abnormal_foam_cell1.87662194
18MP0004043_abnormal_pH_regulation1.73879907
19MP0000609_abnormal_liver_physiology1.70948405
20MP0009697_abnormal_copulation1.69590747
21MP0002118_abnormal_lipid_homeostasis1.63316579
22MP0002132_abnormal_respiratory_system1.58429063
23MP0005670_abnormal_white_adipose1.58263899
24MP0001764_abnormal_homeostasis1.55055345
25MP0010234_abnormal_vibrissa_follicle1.54395618
26MP0009643_abnormal_urine_homeostasis1.39742015
27MP0010155_abnormal_intestine_physiology1.31043035
28MP0005636_abnormal_mineral_homeostasis1.25185401
29MP0005319_abnormal_enzyme/_coenzyme1.20554848
30MP0010368_abnormal_lymphatic_system1.13869417
31MP0004782_abnormal_surfactant_physiolog1.08932248
32MP0003866_abnormal_defecation1.07890527
33MP0008872_abnormal_physiological_respon1.04506509
34MP0005451_abnormal_body_composition1.02268055
35MP0005166_decreased_susceptibility_to1.01853388
36MP0005584_abnormal_enzyme/coenzyme_acti1.01040590
37MP0001663_abnormal_digestive_system0.95488102
38MP0005408_hypopigmentation0.91375488
39MP0004264_abnormal_extraembryonic_tissu0.90905949
40MP0002971_abnormal_brown_adipose0.90853221
41MP0009764_decreased_sensitivity_to0.87880687
42MP0001664_abnormal_digestion0.85647281
43MP0003879_abnormal_hair_cell0.85201506
44MP0009642_abnormal_blood_homeostasis0.84625792
45MP0009785_altered_susceptibility_to0.84126991
46MP0000598_abnormal_liver_morphology0.83834450
47MP0000604_amyloidosis0.83649551
48MP0000566_synostosis0.82864040
49MP0001765_abnormal_ion_homeostasis0.80815896
50MP0005381_digestive/alimentary_phenotyp0.80580454
51MP0008469_abnormal_protein_level0.79951095
52MP0000477_abnormal_intestine_morphology0.78502951
53MP0002136_abnormal_kidney_physiology0.78263368
54MP0009379_abnormal_foot_pigmentation0.75843753
55MP0009763_increased_sensitivity_to0.75745323
56MP0010352_gastrointestinal_tract_polyps0.71821975
57MP0005376_homeostasis/metabolism_phenot0.71700624
58MP0002249_abnormal_larynx_morphology0.71237591
59MP0000467_abnormal_esophagus_morphology0.71005091
60MP0000678_abnormal_parathyroid_gland0.69421108
61MP0003656_abnormal_erythrocyte_physiolo0.68986497
62MP0005535_abnormal_body_temperature0.68908992
63MP0003183_abnormal_peptide_metabolism0.67943158
64MP0009053_abnormal_anal_canal0.63656544
65MP0002168_other_aberrant_phenotype0.63215752
66MP0005395_other_phenotype0.62943004
67MP0002078_abnormal_glucose_homeostasis0.62676629
68MP0001756_abnormal_urination0.62507951
69MP0005409_darkened_coat_color0.60579898
70MP0001661_extended_life_span0.58173620
71MP0001873_stomach_inflammation0.56079740
72MP0000462_abnormal_digestive_system0.55404186
73MP0005023_abnormal_wound_healing0.54504638
74MP0000249_abnormal_blood_vessel0.53792768
75MP0001845_abnormal_inflammatory_respons0.52709424
76MP0009765_abnormal_xenobiotic_induced0.52415260
77MP0003186_abnormal_redox_activity0.51356676
78MP0003075_altered_response_to0.51065805
79MP0005083_abnormal_biliary_tract0.49846064
80MP0005334_abnormal_fat_pad0.49540227
81MP0008874_decreased_physiological_sensi0.49273199
82MP0005448_abnormal_energy_balance0.48750884
83MP0005666_abnormal_adipose_tissue0.48563464
84MP0004147_increased_porphyrin_level0.47239649
85MP0009780_abnormal_chondrocyte_physiolo0.44844180
86MP0000490_abnormal_crypts_of0.44376256
87MP0002282_abnormal_trachea_morphology0.44325531
88MP0003638_abnormal_response/metabolism_0.44249819
89MP0003953_abnormal_hormone_level0.43183640
90MP0005058_abnormal_lysosome_morphology0.42235229
91MP0005266_abnormal_metabolism0.40387541
92MP0005165_increased_susceptibility_to0.39935783
93MP0006036_abnormal_mitochondrial_physio0.39069293
94MP0009115_abnormal_fat_cell0.38845536
95MP0005025_abnormal_response_to0.37779078
96MP0005464_abnormal_platelet_physiology0.37538669
97MP0003303_peritoneal_inflammation0.37080369
98MP0005164_abnormal_response_to0.36981143
99MP0003705_abnormal_hypodermis_morpholog0.36749204
100MP0002796_impaired_skin_barrier0.36031006

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.81964901
2Complement deficiency (HP:0004431)8.72781369
3Deep venous thrombosis (HP:0002625)7.34933978
4Abnormality of complement system (HP:0005339)7.19885332
5Abnormality of aromatic amino acid family metabolism (HP:0004338)7.07185357
6Prolonged partial thromboplastin time (HP:0003645)6.68586436
7Hypobetalipoproteinemia (HP:0003563)6.31154607
8Systemic lupus erythematosus (HP:0002725)6.27371397
9Conjugated hyperbilirubinemia (HP:0002908)6.27294894
10Glomerulonephritis (HP:0000099)5.23437911
11Abnormality of glutamine family amino acid metabolism (HP:0010902)5.21063710
12Intrahepatic cholestasis (HP:0001406)5.04102296
13Joint hemorrhage (HP:0005261)4.75138151
14Hyperlipoproteinemia (HP:0010980)4.73840085
15Xanthomatosis (HP:0000991)4.43808721
16Abnormality of pyrimidine metabolism (HP:0004353)4.14672439
17Recurrent gram-negative bacterial infections (HP:0005420)4.03131277
18Fat malabsorption (HP:0002630)3.97055015
19Nephritis (HP:0000123)3.89567895
20Hypolipoproteinemia (HP:0010981)3.70448674
21Hyperactive renin-angiotensin system (HP:0000841)3.65651017
22Hemorrhage of the eye (HP:0011885)3.35675129
23Hyperammonemia (HP:0001987)3.35528743
24Spontaneous abortion (HP:0005268)3.30556348
25Abnormality of the common coagulation pathway (HP:0010990)3.29059666
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.26488945
27Alkalosis (HP:0001948)3.25097121
28Steatorrhea (HP:0002570)2.90654854
29Abnormality of the intrinsic pathway (HP:0010989)2.87694602
30Vascular calcification (HP:0004934)2.80504516
31Hypoalphalipoproteinemia (HP:0003233)2.76280763
32Hydroxyprolinuria (HP:0003080)2.70891780
33Abnormality of proline metabolism (HP:0010907)2.70891780
34Abnormality of glycine metabolism (HP:0010895)2.66206933
35Abnormality of serine family amino acid metabolism (HP:0010894)2.66206933
36Abnormality of nucleobase metabolism (HP:0010932)2.66053746
37Decreased circulating renin level (HP:0003351)2.62199756
38Abnormality of vitamin metabolism (HP:0100508)2.61645395
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61398822
40Hyperglycinemia (HP:0002154)2.60806007
41Delayed CNS myelination (HP:0002188)2.53861527
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49304796
43Cardiovascular calcification (HP:0011915)2.47586223
44Abnormality of methionine metabolism (HP:0010901)2.47070993
45Epidermoid cyst (HP:0200040)2.40375748
46Rickets (HP:0002748)2.39067453
47Gingival bleeding (HP:0000225)2.37757261
48Malnutrition (HP:0004395)2.37598602
49Abnormality of renin-angiotensin system (HP:0000847)2.34772136
50Hyperbilirubinemia (HP:0002904)2.33993815
51Metabolic acidosis (HP:0001942)2.32567316
52Neonatal hypoglycemia (HP:0001998)2.28562835
53Flat acetabular roof (HP:0003180)2.27436410
54Metabolic alkalosis (HP:0200114)2.26818941
55Hyperglycinuria (HP:0003108)2.22531769
56Generalized aminoaciduria (HP:0002909)2.20447270
57Purpura (HP:0000979)2.19607260
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.16730292
59Gout (HP:0001997)2.16382122
60Abnormality of serum amino acid levels (HP:0003112)2.14447750
61Hypercholesterolemia (HP:0003124)2.13723661
62Ileus (HP:0002595)2.12888427
63Mitral stenosis (HP:0001718)2.12315107
64Osteomalacia (HP:0002749)2.11876750
65Abnormal respiratory motile cilium physiology (HP:0012261)2.11585742
66Rhinitis (HP:0012384)2.09341493
67Abnormal respiratory motile cilium morphology (HP:0005938)2.08496052
68Abnormal respiratory epithelium morphology (HP:0012253)2.08496052
69Abdominal distention (HP:0003270)2.06858826
70Thrombophlebitis (HP:0004418)2.06794496
71Chronic bronchitis (HP:0004469)2.04640301
72Abnormality of urine glucose concentration (HP:0011016)2.01387113
73Glycosuria (HP:0003076)2.01387113
74Abnormal ciliary motility (HP:0012262)1.99577438
75Abnormality of purine metabolism (HP:0004352)1.97936845
76Cerebral palsy (HP:0100021)1.97838781
77Abnormality of chloride homeostasis (HP:0011422)1.95422588
78Pulmonary embolism (HP:0002204)1.94205337
79Dynein arm defect of respiratory motile cilia (HP:0012255)1.93260834
80Absent/shortened dynein arms (HP:0200106)1.93260834
81Hepatocellular carcinoma (HP:0001402)1.92058657
82Hyperphosphaturia (HP:0003109)1.90847348
83Fair hair (HP:0002286)1.89909952
84Pancreatitis (HP:0001733)1.85980057
85Abnormal enzyme/coenzyme activity (HP:0012379)1.83816305
86Elevated alkaline phosphatase (HP:0003155)1.81317041
87Irritability (HP:0000737)1.80109053
88Abnormality of alkaline phosphatase activity (HP:0004379)1.79674985
89Abnormality of the nasal mucosa (HP:0000433)1.77937065
90Ketosis (HP:0001946)1.76613384
91Nasal polyposis (HP:0100582)1.75137569
92Bronchiectasis (HP:0002110)1.69630331
93Skin nodule (HP:0200036)1.69509541
94Increased purine levels (HP:0004368)1.67486051
95Hyperuricemia (HP:0002149)1.67486051
96Abnormality of iron homeostasis (HP:0011031)1.67149260
97Hyperaldosteronism (HP:0000859)1.66433830
98Nephrolithiasis (HP:0000787)1.65333662
99Joint swelling (HP:0001386)1.65293051
100Widely patent fontanelles and sutures (HP:0004492)1.65174492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.01033215
2EPHA24.71559387
3LMTK24.69849548
4ERN14.41898727
5RIPK13.98625727
6PIK3CA3.96619314
7ACVR1B3.85183779
8MAPK152.75270988
9FGFR42.40306018
10PRKG21.97180056
11MET1.89104803
12MAP3K21.88467979
13EPHA31.73860294
14TYK21.67612421
15TRIB31.55177494
16MST41.50257480
17PTK61.44061079
18EPHB11.35825440
19PRKAA21.28843669
20STK391.28431213
21MAP3K31.25326121
22EPHB21.23924309
23MYLK1.22618278
24STK241.21435248
25MAPKAPK31.18275419
26FGFR31.16956715
27PRKACG1.14673090
28MAP3K121.12066244
29PDPK11.10037533
30ERBB21.09248501
31MAP3K11.04960404
32PDK21.03526540
33TBK11.02577241
34MAPK111.02340878
35FER1.02145004
36OXSR11.01305555
37SIK11.00292194
38ABL21.00045943
39PRPF4B0.99852065
40NLK0.97986109
41SMG10.92947513
42MAP2K20.87790905
43TESK10.84489830
44EPHA40.73525655
45ZAP700.66991340
46PDK10.65441332
47MAP2K60.63835852
48IGF1R0.62070251
49PIK3CG0.61920786
50JAK10.61775165
51TAOK10.59076668
52GRK60.57666446
53PRKCA0.57635467
54MAP3K100.55022999
55DYRK1B0.52784293
56SRC0.52741964
57CDC42BPA0.51559240
58CSK0.51231136
59DDR20.50699033
60PRKCZ0.50508906
61MAP2K40.50014315
62RET0.48383240
63GRK10.47810799
64ICK0.47542341
65JAK20.46506733
66PTK20.45641837
67CAMK2G0.45443085
68MAP3K110.44979386
69PRKAA10.43940379
70CAMK2D0.43937727
71PRKG10.43583928
72EEF2K0.42042042
73PRKACA0.41844609
74STK380.40604769
75PRKCQ0.37965591
76CDK60.36357221
77IRAK10.34025694
78NEK60.33375325
79MATK0.32995548
80PKN20.32915696
81BCKDK0.31341731
82MAP3K70.30660378
83MAPK70.29222034
84SGK10.28852185
85NEK10.28384162
86PRKCI0.27179990
87PRKCD0.27023292
88KSR20.26968600
89TRPM70.26198703
90PRKCB0.25863082
91CSNK1A10.23341105
92IKBKE0.22852658
93TIE10.22812088
94LRRK20.22683431
95RIPK40.21874663
96PAK40.21775364
97FYN0.21334642
98CSF1R0.20578858
99MAP2K10.16953694
100MAP4K10.16863648

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.17706049
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.59499082
3* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.49133668
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.36024310
5* Retinol metabolism_Homo sapiens_hsa008303.32581046
6Complement and coagulation cascades_Homo sapiens_hsa046103.17770678
7Primary bile acid biosynthesis_Homo sapiens_hsa001203.13682717
8* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.12369126
9* Chemical carcinogenesis_Homo sapiens_hsa052043.02890189
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.89880031
11Arginine biosynthesis_Homo sapiens_hsa002202.75081291
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.66819336
13Phenylalanine metabolism_Homo sapiens_hsa003602.64274510
14Histidine metabolism_Homo sapiens_hsa003402.60795339
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.51419758
16* Fatty acid degradation_Homo sapiens_hsa000712.45979212
17Cyanoamino acid metabolism_Homo sapiens_hsa004602.35545761
18* Tyrosine metabolism_Homo sapiens_hsa003502.25492478
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07537377
20Bile secretion_Homo sapiens_hsa049761.86417205
21Starch and sucrose metabolism_Homo sapiens_hsa005001.84168215
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.81975439
23Linoleic acid metabolism_Homo sapiens_hsa005911.78725945
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76121843
25Tryptophan metabolism_Homo sapiens_hsa003801.71952972
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57759406
27Sulfur metabolism_Homo sapiens_hsa009201.55629900
28Butanoate metabolism_Homo sapiens_hsa006501.54154676
29PPAR signaling pathway_Homo sapiens_hsa033201.49863362
30Fat digestion and absorption_Homo sapiens_hsa049751.39629970
31Staphylococcus aureus infection_Homo sapiens_hsa051501.25602486
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24987287
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21325670
34Arachidonic acid metabolism_Homo sapiens_hsa005901.19154253
35beta-Alanine metabolism_Homo sapiens_hsa004101.17159780
36Peroxisome_Homo sapiens_hsa041461.14230751
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12802997
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10988116
39Arginine and proline metabolism_Homo sapiens_hsa003301.06283477
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.00650603
41Prion diseases_Homo sapiens_hsa050200.97095635
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96291132
43* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94354921
44Biosynthesis of amino acids_Homo sapiens_hsa012300.92315383
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91586620
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.90763198
47Pyruvate metabolism_Homo sapiens_hsa006200.88262303
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84315899
49Carbon metabolism_Homo sapiens_hsa012000.73526854
50Mineral absorption_Homo sapiens_hsa049780.73391003
51Fructose and mannose metabolism_Homo sapiens_hsa000510.70634686
52Propanoate metabolism_Homo sapiens_hsa006400.67267959
53ABC transporters_Homo sapiens_hsa020100.66243395
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63023510
55Fatty acid metabolism_Homo sapiens_hsa012120.61339479
56Vitamin B6 metabolism_Homo sapiens_hsa007500.60395821
57Nitrogen metabolism_Homo sapiens_hsa009100.57689191
58Renin-angiotensin system_Homo sapiens_hsa046140.56724389
59Glycerolipid metabolism_Homo sapiens_hsa005610.55428848
60Sulfur relay system_Homo sapiens_hsa041220.55427291
61Vitamin digestion and absorption_Homo sapiens_hsa049770.54921359
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50425873
63Glutathione metabolism_Homo sapiens_hsa004800.43121041
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40214384
65* Metabolic pathways_Homo sapiens_hsa011000.39053031
66Pertussis_Homo sapiens_hsa051330.34306041
67Galactose metabolism_Homo sapiens_hsa000520.32874682
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31392249
69Insulin resistance_Homo sapiens_hsa049310.29423390
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22176137
71Pentose phosphate pathway_Homo sapiens_hsa000300.20946642
72One carbon pool by folate_Homo sapiens_hsa006700.20163323
73Other glycan degradation_Homo sapiens_hsa005110.19669486
74Protein digestion and absorption_Homo sapiens_hsa049740.18693401
75Pancreatic secretion_Homo sapiens_hsa049720.18329283
76Lysine degradation_Homo sapiens_hsa003100.14182027
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13959606
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12873420
79Glucagon signaling pathway_Homo sapiens_hsa049220.12850688
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.11761224
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07899165
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.07309103
83Sphingolipid metabolism_Homo sapiens_hsa006000.04807396
84Fatty acid elongation_Homo sapiens_hsa000620.02902617
85Amoebiasis_Homo sapiens_hsa051460.02579526
86Folate biosynthesis_Homo sapiens_hsa007900.01982388
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.01017015
88AMPK signaling pathway_Homo sapiens_hsa041520.00299334
89Insulin signaling pathway_Homo sapiens_hsa04910-0.1537036
90Ether lipid metabolism_Homo sapiens_hsa00565-0.1330723
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.1298024
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1071510
93Tight junction_Homo sapiens_hsa04530-0.1022910
94Serotonergic synapse_Homo sapiens_hsa04726-0.0993750
95African trypanosomiasis_Homo sapiens_hsa05143-0.0965924
96Hepatitis C_Homo sapiens_hsa05160-0.0869559
97Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0412527
98Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0362152
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0197988
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0042545

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