ADH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.44627992
2omega-hydroxylase P450 pathway (GO:0097267)9.42991514
3epoxygenase P450 pathway (GO:0019373)9.29073091
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.62003923
5L-phenylalanine catabolic process (GO:0006559)7.62003923
6L-phenylalanine metabolic process (GO:0006558)7.26517470
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.26517470
8* ethanol oxidation (GO:0006069)7.11319387
9aromatic amino acid family catabolic process (GO:0009074)6.96882816
10indole-containing compound catabolic process (GO:0042436)6.42766665
11indolalkylamine catabolic process (GO:0046218)6.42766665
12tryptophan catabolic process (GO:0006569)6.42766665
13drug metabolic process (GO:0017144)6.41562635
14kynurenine metabolic process (GO:0070189)6.27883147
15oxidative demethylation (GO:0070989)6.26094494
16bile acid biosynthetic process (GO:0006699)6.18334078
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.17702119
18tryptophan metabolic process (GO:0006568)6.02714131
19glyoxylate metabolic process (GO:0046487)5.87279484
20urea cycle (GO:0000050)5.71835687
21urea metabolic process (GO:0019627)5.71835687
22complement activation, alternative pathway (GO:0006957)5.67428063
23alpha-linolenic acid metabolic process (GO:0036109)5.60748413
24regulation of protein activation cascade (GO:2000257)5.60254610
25* ethanol metabolic process (GO:0006067)5.59290198
26negative regulation of fibrinolysis (GO:0051918)5.58180537
27cysteine metabolic process (GO:0006534)5.45154315
28regulation of fibrinolysis (GO:0051917)5.41734314
29peptidyl-glutamic acid carboxylation (GO:0017187)5.41445047
30protein carboxylation (GO:0018214)5.41445047
31high-density lipoprotein particle remodeling (GO:0034375)5.41299492
32sulfur amino acid catabolic process (GO:0000098)5.38921003
33regulation of complement activation (GO:0030449)5.28065083
34nitrogen cycle metabolic process (GO:0071941)5.25769367
35bile acid metabolic process (GO:0008206)5.21441295
36S-adenosylmethionine metabolic process (GO:0046500)5.20520607
37serine family amino acid catabolic process (GO:0009071)5.13912690
38phenylpropanoid metabolic process (GO:0009698)5.09716343
39aromatic amino acid family metabolic process (GO:0009072)5.05310854
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.02902156
41regulation of plasminogen activation (GO:0010755)4.97768629
42homocysteine metabolic process (GO:0050667)4.88602613
43tyrosine metabolic process (GO:0006570)4.77876300
44regulation of triglyceride catabolic process (GO:0010896)4.77390594
45reverse cholesterol transport (GO:0043691)4.71517393
46alpha-amino acid catabolic process (GO:1901606)4.69276871
47lysine catabolic process (GO:0006554)4.68430948
48lysine metabolic process (GO:0006553)4.68430948
49negative regulation of protein activation cascade (GO:2000258)4.65357495
50regulation of cholesterol esterification (GO:0010872)4.64905922
51protein-lipid complex remodeling (GO:0034368)4.64235134
52macromolecular complex remodeling (GO:0034367)4.64235134
53plasma lipoprotein particle remodeling (GO:0034369)4.64235134
54acylglycerol homeostasis (GO:0055090)4.60760563
55triglyceride homeostasis (GO:0070328)4.60760563
56amino-acid betaine metabolic process (GO:0006577)4.60156290
57regulation of humoral immune response (GO:0002920)4.57872833
58coenzyme catabolic process (GO:0009109)4.57148894
59bile acid and bile salt transport (GO:0015721)4.55801243
60indolalkylamine metabolic process (GO:0006586)4.54502356
61glycine metabolic process (GO:0006544)4.54476421
62killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.53909156
63disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.53909156
64negative regulation of blood coagulation (GO:0030195)4.52645816
65negative regulation of hemostasis (GO:1900047)4.52645816
66negative regulation of cholesterol transport (GO:0032375)4.50406384
67negative regulation of sterol transport (GO:0032372)4.50406384
68imidazole-containing compound metabolic process (GO:0052803)4.48986776
69amine catabolic process (GO:0009310)4.45621784
70cellular biogenic amine catabolic process (GO:0042402)4.45621784
71phospholipid efflux (GO:0033700)4.43148239
72cellular glucuronidation (GO:0052695)4.41363535
73cellular ketone body metabolic process (GO:0046950)4.40706230
74alkaloid metabolic process (GO:0009820)4.39105321
75acute-phase response (GO:0006953)4.34952099
76cellular amino acid catabolic process (GO:0009063)4.31669175
77glutamate metabolic process (GO:0006536)4.28774315
78plasma lipoprotein particle clearance (GO:0034381)4.27875140
79serine family amino acid metabolic process (GO:0009069)4.26312218
80benzene-containing compound metabolic process (GO:0042537)4.16997253
81cholesterol efflux (GO:0033344)4.14150024
82negative regulation of coagulation (GO:0050819)4.11816854
83cellular modified amino acid catabolic process (GO:0042219)4.09864916
84dicarboxylic acid biosynthetic process (GO:0043650)4.09540621
85serine family amino acid biosynthetic process (GO:0009070)4.08950327
86negative regulation of wound healing (GO:0061045)4.08270634
87cytolysis (GO:0019835)4.07762503
88positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.04350237
89aldehyde catabolic process (GO:0046185)4.02824826
90complement activation, classical pathway (GO:0006958)4.00175270
91fibrinolysis (GO:0042730)3.99738985
92arginine metabolic process (GO:0006525)3.99715870
93low-density lipoprotein particle remodeling (GO:0034374)3.96347876
94positive regulation of hemostasis (GO:1900048)3.92518382
95positive regulation of blood coagulation (GO:0030194)3.92518382
96negative regulation of complement activation (GO:0045916)3.92510382
97complement activation (GO:0006956)3.91825574
98glucuronate metabolic process (GO:0019585)3.91432925
99uronic acid metabolic process (GO:0006063)3.91432925
100plasma lipoprotein particle assembly (GO:0034377)3.89828796
101intestinal cholesterol absorption (GO:0030299)3.87910499
102blood coagulation, intrinsic pathway (GO:0007597)3.84268330
103cofactor catabolic process (GO:0051187)3.84173346
104flavonoid metabolic process (GO:0009812)3.83746206
105protein activation cascade (GO:0072376)3.83272640
106ketone body metabolic process (GO:1902224)3.81479596
107acetyl-CoA metabolic process (GO:0006084)3.80157268
108regulation of bile acid biosynthetic process (GO:0070857)3.79815503
109very-low-density lipoprotein particle assembly (GO:0034379)3.76677707
110carboxylic acid catabolic process (GO:0046395)3.75486237
111organic acid catabolic process (GO:0016054)3.75486237
112regulation of cholesterol homeostasis (GO:2000188)3.72975750
113positive regulation of lipoprotein lipase activity (GO:0051006)3.72579047
114positive regulation of triglyceride lipase activity (GO:0061365)3.72579047
115cholesterol homeostasis (GO:0042632)3.72411514
116drug catabolic process (GO:0042737)3.71440673
117phospholipid homeostasis (GO:0055091)3.70441046
118sterol homeostasis (GO:0055092)3.66215570
119positive regulation of lipid catabolic process (GO:0050996)3.66082227
120short-chain fatty acid metabolic process (GO:0046459)3.65416141
121sodium-independent organic anion transport (GO:0043252)3.60199854
122NAD biosynthetic process (GO:0009435)3.59622916
123positive regulation of coagulation (GO:0050820)3.59208168
124negative regulation of lipase activity (GO:0060192)3.57820617
125nicotinamide nucleotide biosynthetic process (GO:0019359)3.55867016
126pyridine nucleotide biosynthetic process (GO:0019363)3.55867016
127plasma lipoprotein particle organization (GO:0071827)3.52946323
128* xenobiotic metabolic process (GO:0006805)3.52596461
129opsonization (GO:0008228)3.51477726
130response to mercury ion (GO:0046689)3.35516851
131heme transport (GO:0015886)3.35353622
132acute inflammatory response (GO:0002526)3.29747441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.38161747
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21896484
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.19430158
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.51018143
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28450768
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.04507969
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.68342707
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.08373672
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.98221014
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06385454
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9533014
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96518973
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92437254
14GBX2_23144817_ChIP-Seq_PC3_Human1.74979272
15* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71033767
16HTT_18923047_ChIP-ChIP_STHdh_Human1.62810789
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.61387674
18CLOCK_20551151_ChIP-Seq_293T_Human1.47737386
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.44513389
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40503453
21GATA1_22025678_ChIP-Seq_K562_Human1.39061461
22ER_23166858_ChIP-Seq_MCF-7_Human1.38297048
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35797879
24IRF1_19129219_ChIP-ChIP_H3396_Human1.33575740
25VDR_22108803_ChIP-Seq_LS180_Human1.30886356
26IGF1R_20145208_ChIP-Seq_DFB_Human1.28939290
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.28202608
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22838562
29RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22336282
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.20059540
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19408032
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18164408
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17283977
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16941339
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14370931
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10154637
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08506199
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07277616
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07112234
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06785491
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04632435
42CDX2_22108803_ChIP-Seq_LS180_Human1.04211655
43STAT3_23295773_ChIP-Seq_U87_Human1.03262048
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02333918
45CRX_20693478_ChIP-Seq_RETINA_Mouse1.02043926
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00934004
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00891829
48PHF8_20622853_ChIP-Seq_HELA_Human1.00785187
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99828799
50ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99269011
51ZNF274_21170338_ChIP-Seq_K562_Hela0.98682661
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98660449
53CBP_20019798_ChIP-Seq_JUKART_Human0.98660449
54TCF4_22108803_ChIP-Seq_LS180_Human0.98553087
55TP53_18474530_ChIP-ChIP_U2OS_Human0.98005035
56CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96937747
57HNFA_21074721_ChIP-Seq_CACO-2_Human0.96863134
58NANOG_19829295_ChIP-Seq_ESCs_Human0.95815592
59SOX2_19829295_ChIP-Seq_ESCs_Human0.95815592
60SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94072823
61TCF4_23295773_ChIP-Seq_U87_Human0.93112971
62NFYA_21822215_ChIP-Seq_K562_Human0.92174987
63FLI1_27457419_Chip-Seq_LIVER_Mouse0.91418815
64* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90674409
65OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89297895
66P300_19829295_ChIP-Seq_ESCs_Human0.87968675
67ETV1_20927104_ChIP-Seq_GIST48_Human0.87687024
68CBX2_22325352_ChIP-Seq_293T-Rex_Human0.86815981
69AR_25329375_ChIP-Seq_VCAP_Human0.86786886
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86170996
71* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86154858
72RUNX2_22187159_ChIP-Seq_PCA_Human0.84402480
73OCT4_18555785_Chip-Seq_ESCs_Mouse0.84264270
74* MYC_19829295_ChIP-Seq_ESCs_Human0.83656274
75FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83304028
76FOXA1_25329375_ChIP-Seq_VCAP_Human0.83304028
77IRF8_22096565_ChIP-ChIP_GC-B_Human0.82894245
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82884615
79SMAD4_21741376_ChIP-Seq_EPCs_Human0.82125855
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81602615
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81549923
82KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81291966
83SMAD4_21799915_ChIP-Seq_A2780_Human0.81026824
84PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80896330
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80583937
86GATA4_25053715_ChIP-Seq_YYC3_Human0.80461368
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79358494
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79237077
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.78948282
90RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78353568
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.78347147
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77614887
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76757492
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76654823
95NFYB_21822215_ChIP-Seq_K562_Human0.75822154
96* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.75576773
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75265916
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.75218435
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74817071
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74125587
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74107340
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74054162
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71702608
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68819930
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68506647
106ZNF263_19887448_ChIP-Seq_K562_Human0.67916942
107NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67371629
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67371629
109ESR2_21235772_ChIP-Seq_MCF-7_Human0.65467920
110RARB_24833708_ChIP-Seq_LIVER_Mouse0.65444732
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61327447
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60944727
113BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57644558
114CEBPB_22108803_ChIP-Seq_LS180_Human0.57201638
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.56704963
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56213223
117TAF15_26573619_Chip-Seq_HEK293_Human0.55884779
118EGR1_19032775_ChIP-ChIP_M12_Human0.53975268
119FOXA1_25552417_ChIP-Seq_VCAP_Human0.53679400
120MYC_19915707_ChIP-ChIP_AK7_Human0.53124006
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52502347
122FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52424511
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52355902
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52236806
125ESET_19884257_ChIP-Seq_ESCs_Mouse0.51494859
126STAT1_17558387_ChIP-Seq_HELA_Human0.50919735
127* AR_20517297_ChIP-Seq_VCAP_Human0.49477345
128LXR_22292898_ChIP-Seq_THP-1_Human0.49154810
129CBP_21632823_ChIP-Seq_H3396_Human0.48996694
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.47846608
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.47488863
132P53_21459846_ChIP-Seq_SAOS-2_Human0.46491940
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.45184236
134* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44467039
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.44245320
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.43958765
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43365074
138BCAT_22108803_ChIP-Seq_LS180_Human0.43278467
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43250167
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.41829410
141TAF2_19829295_ChIP-Seq_ESCs_Human0.41738659
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41712729
143BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.40978103
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.40535507
145FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.40078540
146E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.39955261
147GATA1_19941827_ChIP-Seq_MEL_Mouse0.39450289
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.39390799
149SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39379564
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.38977410
151STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38860844
152PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38792161
153GATA6_25053715_ChIP-Seq_YYC3_Human0.38713506
154GATA1_19941826_ChIP-Seq_K562_Human0.37506205
155GATA2_19941826_ChIP-Seq_K562_Human0.37087035
156SPI1_26923725_Chip-Seq_HPCs_Mouse0.36862678
157LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36704100
158NCOR_22424771_ChIP-Seq_293T_Human0.35310128
159* MYC_27129775_Chip-Seq_CORNEA_Mouse0.34876320
160ERG_20517297_ChIP-Seq_VCAP_Human0.34538053
161FOXH1_21741376_ChIP-Seq_EPCs_Human0.34165850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.40644805
2MP0005360_urolithiasis7.67637824
3MP0005085_abnormal_gallbladder_physiolo6.54593567
4MP0005365_abnormal_bile_salt6.19554080
5MP0008875_abnormal_xenobiotic_pharmacok5.00142415
6MP0003806_abnormal_nucleotide_metabolis4.41326510
7MP0003252_abnormal_bile_duct4.00129778
8MP0010329_abnormal_lipoprotein_level3.57416764
9MP0009840_abnormal_foam_cell3.14721506
10MP0005083_abnormal_biliary_tract3.06863935
11MP0003195_calcinosis2.81192339
12MP0005332_abnormal_amino_acid2.71852251
13MP0001666_abnormal_nutrient_absorption2.65623709
14MP0003191_abnormal_cellular_cholesterol2.15790934
15MP0000609_abnormal_liver_physiology2.15411207
16MP0002118_abnormal_lipid_homeostasis2.08884742
17MP0004019_abnormal_vitamin_homeostasis2.07942098
18MP0003868_abnormal_feces_composition1.94819804
19MP0002138_abnormal_hepatobiliary_system1.91473827
20MP0005319_abnormal_enzyme/_coenzyme1.83153288
21MP0001764_abnormal_homeostasis1.66532432
22MP0009697_abnormal_copulation1.63893192
23MP0005584_abnormal_enzyme/coenzyme_acti1.55514372
24MP0003011_delayed_dark_adaptation1.32160647
25MP0005451_abnormal_body_composition1.31447542
26MP0003186_abnormal_redox_activity1.23508039
27MP0005647_abnormal_sex_gland1.20315489
28MP0009643_abnormal_urine_homeostasis1.19752644
29MP0003656_abnormal_erythrocyte_physiolo1.19540152
30MP0000598_abnormal_liver_morphology1.16434326
31MP0003705_abnormal_hypodermis_morpholog1.15783344
32MP0009764_decreased_sensitivity_to1.05720881
33MP0000604_amyloidosis1.02633478
34MP0002254_reproductive_system_inflammat1.01036140
35MP0009763_increased_sensitivity_to1.00850087
36MP0002282_abnormal_trachea_morphology0.99808331
37MP0010368_abnormal_lymphatic_system0.95086187
38MP0005636_abnormal_mineral_homeostasis0.90014076
39MP0008469_abnormal_protein_level0.88639962
40MP0009642_abnormal_blood_homeostasis0.85489742
41MP0005408_hypopigmentation0.84518011
42MP0006036_abnormal_mitochondrial_physio0.81209833
43MP0005084_abnormal_gallbladder_morpholo0.79349048
44MP0005187_abnormal_penis_morphology0.79075691
45MP0005376_homeostasis/metabolism_phenot0.79046623
46MP0002876_abnormal_thyroid_physiology0.77638286
47MP0009765_abnormal_xenobiotic_induced0.76448465
48MP0002078_abnormal_glucose_homeostasis0.75990774
49MP0005220_abnormal_exocrine_pancreas0.74701264
50MP0003879_abnormal_hair_cell0.72621376
51MP0002971_abnormal_brown_adipose0.70084472
52MP0004130_abnormal_muscle_cell0.69728512
53MP0005670_abnormal_white_adipose0.68842099
54MP0005334_abnormal_fat_pad0.68436214
55MP0005535_abnormal_body_temperature0.68039946
56MP0005266_abnormal_metabolism0.66112069
57MP0003690_abnormal_glial_cell0.65764391
58MP0001661_extended_life_span0.65749073
59MP0009053_abnormal_anal_canal0.63186159
60MP0005551_abnormal_eye_electrophysiolog0.60982296
61MP0003329_amyloid_beta_deposits0.60435267
62MP0002249_abnormal_larynx_morphology0.60158783
63MP0006035_abnormal_mitochondrial_morpho0.58790423
64MP0000639_abnormal_adrenal_gland0.58576666
65MP0001986_abnormal_taste_sensitivity0.56727958
66MP0005448_abnormal_energy_balance0.54361150
67MP0004381_abnormal_hair_follicle0.53761388
68MP0001756_abnormal_urination0.53164007
69MP0001915_intracranial_hemorrhage0.51619251
70MP0009785_altered_susceptibility_to0.50563020
71MP0002822_catalepsy0.50270364
72MP0006292_abnormal_olfactory_placode0.49168601
73MP0002928_abnormal_bile_duct0.49078498
74MP0005464_abnormal_platelet_physiology0.48255575
75MP0005395_other_phenotype0.46407349
76MP0003718_maternal_effect0.45524078
77MP0005377_hearing/vestibular/ear_phenot0.44442964
78MP0003878_abnormal_ear_physiology0.44442964
79MP0008874_decreased_physiological_sensi0.43951913
80MP0003724_increased_susceptibility_to0.43801450
81MP0003638_abnormal_response/metabolism_0.43550044
82MP0004142_abnormal_muscle_tone0.43396363
83MP0004782_abnormal_surfactant_physiolog0.43329489
84MP0000579_abnormal_nail_morphology0.42548879
85MP0008873_increased_physiological_sensi0.42324319
86MP0005166_decreased_susceptibility_to0.42132358
87MP0002136_abnormal_kidney_physiology0.41674947
88MP0003436_decreased_susceptibility_to0.41594723
89MP0005248_abnormal_Harderian_gland0.40273824
90MP0009384_cardiac_valve_regurgitation0.39621749
91MP0003953_abnormal_hormone_level0.39571079
92MP0002837_dystrophic_cardiac_calcinosis0.39543575
93MP0005646_abnormal_pituitary_gland0.39140928
94MP0004043_abnormal_pH_regulation0.38832497
95MP0003075_altered_response_to0.38704890
96MP0002796_impaired_skin_barrier0.35721186
97MP0006082_CNS_inflammation0.35616037
98MP0009672_abnormal_birth_weight0.35505935
99MP0009745_abnormal_behavioral_response0.34640318
100MP0008872_abnormal_physiological_respon0.32982367
101MP0005666_abnormal_adipose_tissue0.32778774
102MP0001501_abnormal_sleep_pattern0.32700131
103MP0002332_abnormal_exercise_endurance0.31895822
104MP0009115_abnormal_fat_cell0.30855825
105MP0003633_abnormal_nervous_system0.30795261
106MP0000566_synostosis0.30723952
107MP0000230_abnormal_systemic_arterial0.30438014
108MP0001853_heart_inflammation0.29930388
109MP0000249_abnormal_blood_vessel0.29870032
110MP0002970_abnormal_white_adipose0.29083425
111MP0002909_abnormal_adrenal_gland0.28965320
112MP0002168_other_aberrant_phenotype0.28878043
113MP0001944_abnormal_pancreas_morphology0.28285828
114MP0001243_abnormal_dermal_layer0.28240815
115MP0001440_abnormal_grooming_behavior0.28193598
116MP0001881_abnormal_mammary_gland0.27935926
117MP0000371_diluted_coat_color0.27722862
118MP0001845_abnormal_inflammatory_respons0.26459760
119MP0000427_abnormal_hair_cycle0.26054131
120MP0004883_abnormal_blood_vessel0.26000543
121MP0002132_abnormal_respiratory_system0.25141578
122MP0002060_abnormal_skin_morphology0.24277670
123MP0005164_abnormal_response_to0.24164955
124MP0004264_abnormal_extraembryonic_tissu0.23151866
125MP0005167_abnormal_blood-brain_barrier0.22298712
126MP0000467_abnormal_esophagus_morphology0.21963831
127MP0003631_nervous_system_phenotype0.21396318

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.60914684
2Deep venous thrombosis (HP:0002625)7.41444312
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.34441999
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.65956301
5Prolonged partial thromboplastin time (HP:0003645)6.62023938
6Hypobetalipoproteinemia (HP:0003563)6.43944221
7Xanthomatosis (HP:0000991)6.26613112
8Complement deficiency (HP:0004431)5.87398732
9Hyperlipoproteinemia (HP:0010980)5.42716111
10Joint hemorrhage (HP:0005261)4.78142943
11Hypolipoproteinemia (HP:0010981)4.72811855
12Epidermoid cyst (HP:0200040)4.59006901
13Hyperammonemia (HP:0001987)4.56339565
14Hyperglycinemia (HP:0002154)4.55691506
15Abnormality of the common coagulation pathway (HP:0010990)4.47000596
16Fat malabsorption (HP:0002630)4.33301134
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.31679223
18Abnormality of complement system (HP:0005339)4.28659714
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.23438707
20Ketosis (HP:0001946)4.21308068
21Abnormality of methionine metabolism (HP:0010901)4.17378585
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08954830
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.05186599
24Hypoalphalipoproteinemia (HP:0003233)4.02359607
25Abnormality of glycine metabolism (HP:0010895)3.94360408
26Abnormality of serine family amino acid metabolism (HP:0010894)3.94360408
27Hyperglycinuria (HP:0003108)3.92100539
28Conjugated hyperbilirubinemia (HP:0002908)3.89198826
29Abnormality of the intrinsic pathway (HP:0010989)3.81834343
30Hypoglycemic coma (HP:0001325)3.80377099
31Abnormality of pyrimidine metabolism (HP:0004353)3.77715799
32Hypercholesterolemia (HP:0003124)3.59972851
33Fair hair (HP:0002286)3.56565626
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36547880
35Hyperbilirubinemia (HP:0002904)3.33053788
36Abnormality of fatty-acid metabolism (HP:0004359)3.29319719
37Steatorrhea (HP:0002570)3.29036499
38Delayed CNS myelination (HP:0002188)3.15494387
39Abnormality of serum amino acid levels (HP:0003112)3.09212554
40Hypochromic microcytic anemia (HP:0004840)3.07059976
41Myocardial infarction (HP:0001658)3.03445887
42Abnormality of nucleobase metabolism (HP:0010932)3.03008255
43Spontaneous abortion (HP:0005268)2.99744970
44Hepatocellular carcinoma (HP:0001402)2.98099206
45Ketoacidosis (HP:0001993)2.97407151
46Neonatal hypoglycemia (HP:0001998)2.93227519
47Systemic lupus erythematosus (HP:0002725)2.91286670
48Skin nodule (HP:0200036)2.83717243
49Metabolic acidosis (HP:0001942)2.72051570
50Osteomalacia (HP:0002749)2.71933282
51Recurrent gram-negative bacterial infections (HP:0005420)2.67620323
52Abnormality of purine metabolism (HP:0004352)2.65654483
53Acanthocytosis (HP:0001927)2.63165850
54Generalized hypopigmentation of hair (HP:0011358)2.58267994
55Lethargy (HP:0001254)2.57296409
56Vascular calcification (HP:0004934)2.55198003
57Dicarboxylic aciduria (HP:0003215)2.53752698
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53752698
59Abnormal gallbladder morphology (HP:0012437)2.50723973
60Spastic diplegia (HP:0001264)2.46786801
61Hypoglycemic seizures (HP:0002173)2.45455778
62Mitral stenosis (HP:0001718)2.44635506
63Cholelithiasis (HP:0001081)2.44046127
64Pulmonary embolism (HP:0002204)2.41188137
65Glomerulonephritis (HP:0000099)2.39827470
66Gout (HP:0001997)2.39650057
67Neonatal onset (HP:0003623)2.38848935
68Cerebral edema (HP:0002181)2.37108639
69Cholecystitis (HP:0001082)2.35702158
70Abnormal gallbladder physiology (HP:0012438)2.35702158
71Malnutrition (HP:0004395)2.32260291
72Irritability (HP:0000737)2.31043388
73Cardiovascular calcification (HP:0011915)2.26073666
74Sensorimotor neuropathy (HP:0007141)2.22372668
75Purpura (HP:0000979)2.21359147
76Esophageal varix (HP:0002040)2.16718992
77Gingival bleeding (HP:0000225)2.15966071
78Amyloidosis (HP:0011034)2.15822120
79Blue irides (HP:0000635)2.15255744
80Arthropathy (HP:0003040)2.14192759
81Pancreatitis (HP:0001733)2.13654525
82Brushfield spots (HP:0001088)2.09757248
83Menorrhagia (HP:0000132)2.09560631
84Late onset (HP:0003584)2.09414071
85Enlarged kidneys (HP:0000105)2.06774251
86Abnormality of the gallbladder (HP:0005264)2.04603610
87Opisthotonus (HP:0002179)2.04217106
88Thrombophlebitis (HP:0004418)2.04198451
89Abnormality of urine glucose concentration (HP:0011016)2.03108129
90Glycosuria (HP:0003076)2.03108129
91Hemorrhage of the eye (HP:0011885)2.03061722
92Vomiting (HP:0002013)2.02561760
93Poikilocytosis (HP:0004447)2.00710839
94Hyperphosphaturia (HP:0003109)2.00159960
95Hyperinsulinemic hypoglycemia (HP:0000825)1.99342981
96Generalized aminoaciduria (HP:0002909)1.96561325
97Rickets (HP:0002748)1.93333346
98Abnormal cartilage morphology (HP:0002763)1.87142742
99Abnormality of iron homeostasis (HP:0011031)1.86257133
100Renal cortical cysts (HP:0000803)1.86148020
101Abnormal enzyme/coenzyme activity (HP:0012379)1.85693222
102Reduced antithrombin III activity (HP:0001976)1.84962837
103Abnormality of transition element cation homeostasis (HP:0011030)1.84646818
104Hypophosphatemic rickets (HP:0004912)1.83236570
105Elevated hepatic transaminases (HP:0002910)1.81927606
106Joint swelling (HP:0001386)1.81672391
107Abnormality of proline metabolism (HP:0010907)1.79729604
108Hydroxyprolinuria (HP:0003080)1.79729604
109Status epilepticus (HP:0002133)1.79119542
110Gangrene (HP:0100758)1.78500525
111Abnormality of vitamin metabolism (HP:0100508)1.77841864
112Hyperglycemia (HP:0003074)1.73338267
113Nephritis (HP:0000123)1.71615870
114Alkalosis (HP:0001948)1.70703077
115Hypothermia (HP:0002045)1.69804222
116Cerebral palsy (HP:0100021)1.68130336
117Abnormal biliary tract physiology (HP:0012439)1.67363645
118Bile duct proliferation (HP:0001408)1.67363645
119Epistaxis (HP:0000421)1.66921268
120Increased serum ferritin (HP:0003281)1.58019292
121Bifid scrotum (HP:0000048)1.57770560
122Abnormal urine phosphate concentration (HP:0012599)1.54358155
123Increased mean platelet volume (HP:0011877)1.50949538
124Elevated alkaline phosphatase (HP:0003155)1.49226563
125Potter facies (HP:0002009)1.48583510
126Facial shape deformation (HP:0011334)1.48583510
127Proximal tubulopathy (HP:0000114)1.46591974

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.97161857
2FGFR44.69082211
3SIK14.56033771
4ERN14.45921939
5TAOK33.32112390
6ERBB43.24477427
7INSRR2.94480548
8WNK32.48047822
9NTRK32.41222753
10PIK3CA2.36542973
11MAP2K42.35679537
12MAP4K22.30469560
13ADRBK22.18292761
14MST1R2.14714869
15PKN22.06486677
16ACVR1B2.05956096
17PIK3CG1.97840197
18MAPK111.97528169
19WNK41.85590418
20FLT31.85134894
21BMPR1B1.84997613
22TYK21.71739354
23LATS11.70009234
24TRIB31.66685825
25FER1.66145310
26CASK1.62895593
27TNK21.59209041
28DAPK21.48436976
29PTK61.48326160
30ABL21.46283898
31FRK1.45745083
32FGFR21.45595906
33NEK91.39152573
34STK391.35355779
35OXSR11.32668411
36NLK1.31370967
37MAP3K71.29947612
38JAK21.26294322
39KDR1.23216307
40CAMKK21.12263012
41PINK11.11524172
42ERBB21.10407689
43PRKAA21.10405477
44JAK11.06281812
45PDK21.05935229
46TBK11.05512854
47MAP3K101.05511641
48GRK61.04507970
49MAP3K141.02973426
50NUAK11.02099728
51MAPK151.00036280
52MAP2K30.98398715
53MAPK40.96512536
54PRKACA0.95612271
55PRKG10.95416979
56PRKCZ0.93783990
57PRKCE0.92060501
58ZAK0.90591262
59MAPK130.89972242
60STK38L0.89396511
61BRSK20.88772771
62MET0.86217610
63AKT30.85988690
64CDK60.83691823
65EPHB10.81213388
66MAPKAPK30.77523095
67TXK0.76237169
68MAPK120.76215124
69EPHA30.76187220
70IRAK30.75730307
71PRKACG0.73827097
72CAMK2G0.73711707
73MAP3K30.73663876
74TIE10.73045614
75MAP3K40.72060414
76CSNK1D0.69771121
77CAMK1D0.69586820
78MAP3K110.68605819
79DYRK1B0.67272373
80PRKAA10.66981009
81CSK0.66787629
82MAP2K60.65955715
83TNIK0.65838678
84ADRBK10.65665779
85GSK3A0.65412025
86RIPK10.61929082
87SGK30.61214045
88FGFR30.59133882
89BCR0.56916473
90MAPK70.56594760
91CSF1R0.56484225
92PRKACB0.56481282
93PRKCB0.55780659
94CSNK1A10.54080309
95PRKCQ0.53710989
96IKBKE0.53461638
97PTK20.53261513
98RPS6KA30.52988718
99PKN10.52774783
100SGK10.51278564
101CSNK1E0.50678150
102PDPK10.50232535
103KIT0.48290892
104TGFBR20.47848150
105CSNK1G10.46197672
106EPHA40.45583915
107ICK0.45455395
108GRK10.44933531
109IGF1R0.44466862
110SGK20.43892934
111STK380.43809275
112MAP3K130.43152650
113MAP3K50.42055723
114CDK40.40494086
115RET0.40386222
116PRKCG0.39949732
117TAOK20.38852127
118MAP2K10.38464411
119MKNK20.37916834
120DYRK1A0.37201270
121CHUK0.36676177
122EGFR0.36276246
123MTOR0.35367079
124MAP3K60.33169952
125CSNK2A10.32835559
126CAMK40.31775324
127PDK10.31705866
128STK110.31409427
129PBK0.30679281
130PDK40.30527324
131PDK30.30527324
132TEC0.30045925
133CAMK2A0.29486998
134PTK2B0.28921908
135IRAK10.28592385
136SGK2230.28517304
137SGK4940.28517304
138IRAK20.28133406
139IKBKB0.28018513
140LATS20.27813442
141MUSK0.27503432
142MAP3K10.27307397
143SRC0.27172011
144CAMK1G0.26816813
145CSNK1G20.26697075
146EIF2AK30.25608004
147PRKCA0.25492343
148PAK30.25122948
149ABL10.23513651
150CSNK1G30.22713683
151BMX0.21548271

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.71348989
2Nitrogen metabolism_Homo sapiens_hsa009103.58354121
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36567449
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32972057
5Arginine biosynthesis_Homo sapiens_hsa002203.05313898
6Complement and coagulation cascades_Homo sapiens_hsa046102.83567313
7Tryptophan metabolism_Homo sapiens_hsa003802.74451737
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66058478
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62384113
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56578337
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40355166
12* Fatty acid degradation_Homo sapiens_hsa000712.36299018
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25536691
14Butanoate metabolism_Homo sapiens_hsa006502.17304531
15Peroxisome_Homo sapiens_hsa041462.10158527
16* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02843819
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.96642447
18Histidine metabolism_Homo sapiens_hsa003401.93605254
19Propanoate metabolism_Homo sapiens_hsa006401.93165962
20PPAR signaling pathway_Homo sapiens_hsa033201.85707164
21* Chemical carcinogenesis_Homo sapiens_hsa052041.83089758
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.80923967
23* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79798599
24Fatty acid metabolism_Homo sapiens_hsa012121.78505398
25Staphylococcus aureus infection_Homo sapiens_hsa051501.77992301
26Caffeine metabolism_Homo sapiens_hsa002321.75353156
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73931182
28beta-Alanine metabolism_Homo sapiens_hsa004101.71709902
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68693869
30Selenocompound metabolism_Homo sapiens_hsa004501.61546440
31* Retinol metabolism_Homo sapiens_hsa008301.59777231
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56758377
33Phenylalanine metabolism_Homo sapiens_hsa003601.55870894
34Bile secretion_Homo sapiens_hsa049761.52177038
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48938760
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48081919
37Sulfur metabolism_Homo sapiens_hsa009201.37975733
38Pyruvate metabolism_Homo sapiens_hsa006201.35480108
39Fatty acid elongation_Homo sapiens_hsa000621.31610319
40Starch and sucrose metabolism_Homo sapiens_hsa005001.31414718
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.30155164
42* Tyrosine metabolism_Homo sapiens_hsa003501.28861146
43ABC transporters_Homo sapiens_hsa020101.23085300
44Folate biosynthesis_Homo sapiens_hsa007901.23055558
45Steroid biosynthesis_Homo sapiens_hsa001001.21537202
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18223783
47Fat digestion and absorption_Homo sapiens_hsa049751.17692975
48Carbon metabolism_Homo sapiens_hsa012001.11519778
49Vitamin B6 metabolism_Homo sapiens_hsa007501.11012163
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05589750
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.04295889
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.97633256
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96211541
54Sulfur relay system_Homo sapiens_hsa041220.95557160
55Arginine and proline metabolism_Homo sapiens_hsa003300.94182701
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87897461
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84895593
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82937588
59Lysine degradation_Homo sapiens_hsa003100.81153996
60One carbon pool by folate_Homo sapiens_hsa006700.78682452
61Glycerolipid metabolism_Homo sapiens_hsa005610.66636795
62Glutathione metabolism_Homo sapiens_hsa004800.64879130
63* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58948232
64Pentose phosphate pathway_Homo sapiens_hsa000300.55891922
65Fatty acid biosynthesis_Homo sapiens_hsa000610.55582584
66Prion diseases_Homo sapiens_hsa050200.49369152
67* Metabolic pathways_Homo sapiens_hsa011000.45512244
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45183777
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44581940
70Pertussis_Homo sapiens_hsa051330.27418326
71Galactose metabolism_Homo sapiens_hsa000520.26269104
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25044107
73Insulin resistance_Homo sapiens_hsa049310.23348257
74Fructose and mannose metabolism_Homo sapiens_hsa000510.22368421
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.22095494
76Linoleic acid metabolism_Homo sapiens_hsa005910.21342323
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18504637
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.16121807
79Serotonergic synapse_Homo sapiens_hsa047260.11734664
80Glucagon signaling pathway_Homo sapiens_hsa049220.10079453
81Mineral absorption_Homo sapiens_hsa049780.05802346
82AMPK signaling pathway_Homo sapiens_hsa041520.00905925
83Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2352876
84Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2308093
85Bladder cancer_Homo sapiens_hsa05219-0.2303640
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2154617
87Type II diabetes mellitus_Homo sapiens_hsa04930-0.2142483
88Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2043466
89Amoebiasis_Homo sapiens_hsa05146-0.2033157
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1935644
91Phototransduction_Homo sapiens_hsa04744-0.1892534
92Renin-angiotensin system_Homo sapiens_hsa04614-0.1891357
93Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1866403
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1769058
95Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1676981
96Hepatitis C_Homo sapiens_hsa05160-0.1673730
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1669778
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1600797
99Sphingolipid metabolism_Homo sapiens_hsa00600-0.1487676
100African trypanosomiasis_Homo sapiens_hsa05143-0.1466934
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1371622
102GABAergic synapse_Homo sapiens_hsa04727-0.1364604
103Regulation of autophagy_Homo sapiens_hsa04140-0.1277234
104Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1185125
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.1045542
106Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1044790
107Insulin signaling pathway_Homo sapiens_hsa04910-0.1040177
108Ether lipid metabolism_Homo sapiens_hsa00565-0.0934437
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0816074
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0808967
111Circadian rhythm_Homo sapiens_hsa04710-0.0796694
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0703460
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0550331

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