ADH5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.71350900
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.71350900
3L-phenylalanine metabolic process (GO:0006558)6.53734800
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.53734800
5aromatic amino acid family catabolic process (GO:0009074)5.91002903
6glyoxylate metabolic process (GO:0046487)5.56295922
7glycine metabolic process (GO:0006544)5.24637563
8indole-containing compound catabolic process (GO:0042436)5.19719781
9indolalkylamine catabolic process (GO:0046218)5.19719781
10tryptophan catabolic process (GO:0006569)5.19719781
11serine family amino acid biosynthetic process (GO:0009070)5.19248330
12bile acid biosynthetic process (GO:0006699)5.15643297
13kynurenine metabolic process (GO:0070189)5.04985266
14tryptophan metabolic process (GO:0006568)5.04270222
15serine family amino acid catabolic process (GO:0009071)5.02754397
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.01078105
17cysteine metabolic process (GO:0006534)4.99411068
18sulfur amino acid catabolic process (GO:0000098)4.82660357
19serine family amino acid metabolic process (GO:0009069)4.75657219
20negative regulation of fibrinolysis (GO:0051918)4.70494787
21urea cycle (GO:0000050)4.65968785
22urea metabolic process (GO:0019627)4.65968785
23L-serine metabolic process (GO:0006563)4.60133907
24alpha-linolenic acid metabolic process (GO:0036109)4.56624760
25regulation of fibrinolysis (GO:0051917)4.48767029
26aromatic amino acid family metabolic process (GO:0009072)4.43327087
27regulation of protein activation cascade (GO:2000257)4.39015809
28homocysteine metabolic process (GO:0050667)4.38949257
29nitrogen cycle metabolic process (GO:0071941)4.37114366
30establishment of integrated proviral latency (GO:0075713)4.34143188
31high-density lipoprotein particle remodeling (GO:0034375)4.33041848
32tyrosine metabolic process (GO:0006570)4.32288240
33complement activation, alternative pathway (GO:0006957)4.29249449
34bile acid metabolic process (GO:0008206)4.28751094
35alpha-amino acid catabolic process (GO:1901606)4.25912370
36imidazole-containing compound metabolic process (GO:0052803)4.16966231
37lysine metabolic process (GO:0006553)4.15827018
38lysine catabolic process (GO:0006554)4.15827018
39regulation of complement activation (GO:0030449)4.09821259
40amino-acid betaine metabolic process (GO:0006577)4.09584448
41protein carboxylation (GO:0018214)4.07552709
42peptidyl-glutamic acid carboxylation (GO:0017187)4.07552709
43* aldehyde catabolic process (GO:0046185)4.07041604
44cellular ketone body metabolic process (GO:0046950)4.04703559
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.93889941
46cellular amino acid catabolic process (GO:0009063)3.93590732
47chromatin remodeling at centromere (GO:0031055)3.87024197
48regulation of cholesterol esterification (GO:0010872)3.82184349
49coenzyme catabolic process (GO:0009109)3.81084395
50indolalkylamine metabolic process (GO:0006586)3.75812195
51CENP-A containing nucleosome assembly (GO:0034080)3.73685714
52amine catabolic process (GO:0009310)3.73204741
53cellular biogenic amine catabolic process (GO:0042402)3.73204741
54regulation of triglyceride catabolic process (GO:0010896)3.72856138
55reverse cholesterol transport (GO:0043691)3.70161980
56negative regulation of cholesterol transport (GO:0032375)3.69528122
57negative regulation of sterol transport (GO:0032372)3.69528122
58triglyceride homeostasis (GO:0070328)3.67908588
59acylglycerol homeostasis (GO:0055090)3.67908588
60protein-lipid complex remodeling (GO:0034368)3.67676631
61macromolecular complex remodeling (GO:0034367)3.67676631
62plasma lipoprotein particle remodeling (GO:0034369)3.67676631
63cellular glucuronidation (GO:0052695)3.64912553
64arginine metabolic process (GO:0006525)3.61937704
65paraxial mesoderm development (GO:0048339)3.60147328
66* ethanol oxidation (GO:0006069)3.54916859
67acetyl-CoA metabolic process (GO:0006084)3.52219655
68one-carbon metabolic process (GO:0006730)3.52216871
69bile acid and bile salt transport (GO:0015721)3.51589759
70ketone body metabolic process (GO:1902224)3.50869919
71benzene-containing compound metabolic process (GO:0042537)3.49500894
72cellular modified amino acid catabolic process (GO:0042219)3.45208202
73carboxylic acid catabolic process (GO:0046395)3.42889324
74organic acid catabolic process (GO:0016054)3.42889324
75tetrahydrofolate metabolic process (GO:0046653)3.42287584
76glutamate metabolic process (GO:0006536)3.38538489
77cofactor catabolic process (GO:0051187)3.36641408
78plasma lipoprotein particle clearance (GO:0034381)3.35765914
79uronic acid metabolic process (GO:0006063)3.34061104
80glucuronate metabolic process (GO:0019585)3.34061104
81aspartate family amino acid catabolic process (GO:0009068)3.31093964
82heme transport (GO:0015886)3.26687170
83mitotic metaphase plate congression (GO:0007080)3.26658087
84phospholipid efflux (GO:0033700)3.24256192
85drug catabolic process (GO:0042737)3.21785155
86protein localization to kinetochore (GO:0034501)3.20751940
87blood coagulation, intrinsic pathway (GO:0007597)3.20213801
88short-chain fatty acid metabolic process (GO:0046459)3.20196438
89branched-chain amino acid catabolic process (GO:0009083)3.19723092
90fibrinolysis (GO:0042730)3.18908791
91folic acid-containing compound biosynthetic process (GO:0009396)3.17880296
92proteasome assembly (GO:0043248)3.15438898
93establishment of viral latency (GO:0019043)3.14675279
94drug metabolic process (GO:0017144)3.14168391
95urate metabolic process (GO:0046415)3.13401324
96histone exchange (GO:0043486)3.12457292
97folic acid metabolic process (GO:0046655)3.11236208
98low-density lipoprotein particle remodeling (GO:0034374)3.09297890
99DNA replication-independent nucleosome assembly (GO:0006336)3.09262179
100DNA replication-independent nucleosome organization (GO:0034724)3.09262179
101pyridine nucleotide biosynthetic process (GO:0019363)3.08247064
102nicotinamide nucleotide biosynthetic process (GO:0019359)3.08247064
103sulfur amino acid metabolic process (GO:0000096)3.06882101
104carnitine metabolic process (GO:0009437)3.06242435
105cholesterol efflux (GO:0033344)3.05140376
106NAD biosynthetic process (GO:0009435)3.04254862
107cholesterol homeostasis (GO:0042632)3.03419973
108* response to nitrosative stress (GO:0051409)3.03139685
109complement activation, classical pathway (GO:0006958)3.02321195
110sulfur amino acid biosynthetic process (GO:0000097)3.02042959
111DNA ligation (GO:0006266)3.01675466
112IMP biosynthetic process (GO:0006188)3.01256404
113fatty acid beta-oxidation (GO:0006635)3.01219810
114purine nucleobase biosynthetic process (GO:0009113)2.99717665
115DNA replication checkpoint (GO:0000076)2.98541817
116DNA strand elongation involved in DNA replication (GO:0006271)2.98498917
117DNA double-strand break processing (GO:0000729)2.97698622
118metaphase plate congression (GO:0051310)2.93214035
119DNA strand elongation (GO:0022616)2.85523607
120ribosome assembly (GO:0042255)2.83629774
121negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82206013
122DNA unwinding involved in DNA replication (GO:0006268)2.81185798
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77636133
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.77636133
125negative regulation of sister chromatid segregation (GO:0033046)2.77636133
126negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77636133
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.77636133
128DNA damage response, detection of DNA damage (GO:0042769)2.77239141
129heterochromatin organization (GO:0070828)2.77224755
130regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.76058175
131spindle checkpoint (GO:0031577)2.75253868
132mitotic spindle checkpoint (GO:0071174)2.72348938
133regulation of helicase activity (GO:0051095)2.71761667
134negative regulation of chromosome segregation (GO:0051985)2.71483799
135double-strand break repair via nonhomologous end joining (GO:0006303)2.70622897
136non-recombinational repair (GO:0000726)2.70622897
137nucleobase biosynthetic process (GO:0046112)2.70247917
138telomere maintenance via semi-conservative replication (GO:0032201)2.69926376
139IMP metabolic process (GO:0046040)2.68797437
140kinetochore organization (GO:0051383)2.65794017
141cullin deneddylation (GO:0010388)2.64885373
142regulation of mitotic spindle checkpoint (GO:1903504)2.64845783
143regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.64845783
144anterior/posterior axis specification, embryo (GO:0008595)2.63653745
145regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63118459
146negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61068500
147negative regulation of ligase activity (GO:0051352)2.61068500
148mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.60301964
149regulation of centriole replication (GO:0046599)2.59083161
150anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.58726204
151ribosomal large subunit biogenesis (GO:0042273)2.58192893
152mitotic sister chromatid segregation (GO:0000070)2.57120134
153regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.56926923
154regulation of mitotic metaphase/anaphase transition (GO:0030071)2.56926923
155ventricular cardiac muscle cell development (GO:0055015)2.56695860
156protein localization to chromosome, centromeric region (GO:0071459)2.54962141
157mitotic recombination (GO:0006312)2.54786542
158sister chromatid segregation (GO:0000819)2.54626466
159formation of translation preinitiation complex (GO:0001731)2.52427428
160cholesterol biosynthetic process (GO:0006695)2.52376903
161female gonad development (GO:0008585)2.52150006
162tRNA aminoacylation for protein translation (GO:0006418)2.52090112
163nuclear pore complex assembly (GO:0051292)2.51776560
164kinetochore assembly (GO:0051382)2.51546814
165regulation of chromosome segregation (GO:0051983)2.48569473
166regulation of posttranscriptional gene silencing (GO:0060147)2.47014698
167regulation of gene silencing by miRNA (GO:0060964)2.47014698
168regulation of gene silencing by RNA (GO:0060966)2.47014698
169mitotic spindle assembly checkpoint (GO:0007094)2.46793749
170amino acid activation (GO:0043038)2.45738977
171tRNA aminoacylation (GO:0043039)2.45738977
172positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.45670942
173DNA replication-dependent nucleosome assembly (GO:0006335)2.45611464
174DNA replication-dependent nucleosome organization (GO:0034723)2.45611464
175regulation of mitotic sister chromatid separation (GO:0010965)2.44882362
176regulation of mitotic sister chromatid segregation (GO:0033047)2.44882362
177regulation of sister chromatid segregation (GO:0033045)2.44882362
178DNA strand renaturation (GO:0000733)2.44437185
179ATP-dependent chromatin remodeling (GO:0043044)2.44220771
180positive regulation of SMAD protein import into nucleus (GO:0060391)2.41356298
181spindle assembly checkpoint (GO:0071173)2.40381025
182negative regulation of DNA-dependent DNA replication (GO:2000104)2.38356961
183sterol biosynthetic process (GO:0016126)2.38012143
184nuclear pore organization (GO:0006999)2.37441809
185notochord development (GO:0030903)2.37287873
186establishment of protein localization to mitochondrial membrane (GO:0090151)2.36178458
187protein deneddylation (GO:0000338)2.35510516
188regulation of cell fate specification (GO:0042659)2.34956041
189telomere maintenance via recombination (GO:0000722)2.34771907
190negative regulation of mitosis (GO:0045839)2.34396278
191protein neddylation (GO:0045116)2.31841779
192response to X-ray (GO:0010165)2.31649665
193G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.30257528
194establishment of chromosome localization (GO:0051303)2.30111634
195regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.28753091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.86707146
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.20357863
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.94131130
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.56203148
5E2F7_22180533_ChIP-Seq_HELA_Human4.30292236
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.11591322
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.74147127
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.67084611
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.51885703
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.16579668
11SALL1_21062744_ChIP-ChIP_HESCs_Human3.15813539
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.93649836
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80724382
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64230912
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62184378
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27944367
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24904230
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20591170
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.20508496
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.20337191
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14663008
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.14496452
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06014015
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99357564
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99342188
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95816653
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92492272
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92114450
29NANOG_16153702_ChIP-ChIP_HESCs_Human1.91769736
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89640002
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88023384
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85382190
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.83737406
34AR_21909140_ChIP-Seq_LNCAP_Human1.82556556
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79168492
36* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77883271
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75409813
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74394704
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72351377
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64666849
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.61797896
42XRN2_22483619_ChIP-Seq_HELA_Human1.57735632
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57062793
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56889620
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55446531
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55269750
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53133066
48FUS_26573619_Chip-Seq_HEK293_Human1.51921807
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.50441004
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48963657
51EWS_26573619_Chip-Seq_HEK293_Human1.47805823
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46648755
53DCP1A_22483619_ChIP-Seq_HELA_Human1.45682013
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41574515
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.36228042
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.35524592
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35153893
58FOXP3_21729870_ChIP-Seq_TREG_Human1.33761979
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32364155
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31959246
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31310166
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31122398
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30364933
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28967061
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26904471
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25779753
67VDR_23849224_ChIP-Seq_CD4+_Human1.24025520
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22435861
69* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22279011
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21320397
71GABP_19822575_ChIP-Seq_HepG2_Human1.20610162
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20229457
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18680412
74ZNF274_21170338_ChIP-Seq_K562_Hela1.16602798
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16583183
76* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15585463
77SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15310562
78SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11051372
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.10965119
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10154518
81IRF1_19129219_ChIP-ChIP_H3396_Human1.09334900
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08341753
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04404600
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.03906431
85OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03271100
86* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03179505
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01588830
88P300_19829295_ChIP-Seq_ESCs_Human1.01389682
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01267686
90CLOCK_20551151_ChIP-Seq_293T_Human1.00646309
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00047250
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00047250
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00047250
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99647805
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99118551
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97908409
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96919109
98HTT_18923047_ChIP-ChIP_STHdh_Human0.95178400
99MYC_18940864_ChIP-ChIP_HL60_Human0.94855946
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93856346
101RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93295936
102* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91563264
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.91202145
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.90718051
105E2F1_21310950_ChIP-Seq_MCF-7_Human0.90522618
106TTF2_22483619_ChIP-Seq_HELA_Human0.90426614
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90128671
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89809126
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89622422
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89491362
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89356648
112TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88438408
113KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88011807
114EOMES_21245162_ChIP-Seq_HESCs_Human0.87893347
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87841064
116* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87762731
117KDM5A_27292631_Chip-Seq_BREAST_Human0.87738571
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87630506
119TP63_19390658_ChIP-ChIP_HaCaT_Human0.87548875
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87283157
121RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86799697
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85594130
123POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84997449
124NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82815295
125TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82466539
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82190009
127TBX3_20139965_ChIP-Seq_MESCs_Mouse0.81068610
128NANOG_18692474_ChIP-Seq_MEFs_Mouse0.80908675
129* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79983900
130ELK1_19687146_ChIP-ChIP_HELA_Human0.78871640
131HNF4A_19822575_ChIP-Seq_HepG2_Human0.78687637
132* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75691575
133SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.75213237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.38494181
2MP0005360_urolithiasis6.82615911
3MP0003806_abnormal_nucleotide_metabolis5.98271583
4MP0005085_abnormal_gallbladder_physiolo5.72311583
5MP0005365_abnormal_bile_salt5.31724632
6MP0008875_abnormal_xenobiotic_pharmacok4.55295011
7MP0003941_abnormal_skin_development3.58016323
8MP0003252_abnormal_bile_duct3.26092768
9MP0010329_abnormal_lipoprotein_level2.88471411
10MP0009840_abnormal_foam_cell2.83244275
11MP0005332_abnormal_amino_acid2.72624535
12MP0003195_calcinosis2.41453582
13MP0005083_abnormal_biliary_tract2.37468795
14MP0004272_abnormal_basement_membrane2.37221562
15MP0006292_abnormal_olfactory_placode2.33053993
16MP0003186_abnormal_redox_activity2.28715989
17MP0008438_abnormal_cutaneous_collagen2.26460112
18MP0001666_abnormal_nutrient_absorption2.13645872
19MP0003122_maternal_imprinting2.04608405
20MP0009697_abnormal_copulation2.04178922
21MP0004019_abnormal_vitamin_homeostasis2.03068635
22MP0003937_abnormal_limbs/digits/tail_de1.99527179
23MP0002938_white_spotting1.88954090
24MP0000609_abnormal_liver_physiology1.82091335
25MP0003011_delayed_dark_adaptation1.81398188
26MP0001299_abnormal_eye_distance/1.79341159
27MP0002233_abnormal_nose_morphology1.75278948
28MP0001764_abnormal_homeostasis1.74376034
29MP0006054_spinal_hemorrhage1.74172859
30MP0008789_abnormal_olfactory_epithelium1.73617528
31MP0005451_abnormal_body_composition1.71939502
32MP0005319_abnormal_enzyme/_coenzyme1.66405611
33MP0003718_maternal_effect1.62028922
34MP0002118_abnormal_lipid_homeostasis1.59953254
35MP0003191_abnormal_cellular_cholesterol1.51570290
36MP0003868_abnormal_feces_composition1.51313968
37MP0005408_hypopigmentation1.47602318
38MP0002138_abnormal_hepatobiliary_system1.45153328
39MP0000049_abnormal_middle_ear1.42702323
40MP0001529_abnormal_vocalization1.41818957
41MP0002084_abnormal_developmental_patter1.38925201
42MP0003121_genomic_imprinting1.38100025
43MP0005499_abnormal_olfactory_system1.35682573
44MP0005394_taste/olfaction_phenotype1.35682573
45MP0005257_abnormal_intraocular_pressure1.35574202
46MP0002085_abnormal_embryonic_tissue1.33659243
47MP0000428_abnormal_craniofacial_morphol1.32921950
48MP0005503_abnormal_tendon_morphology1.31342693
49MP0003755_abnormal_palate_morphology1.30827210
50MP0006036_abnormal_mitochondrial_physio1.30339434
51MP0003385_abnormal_body_wall1.29568225
52MP0005584_abnormal_enzyme/coenzyme_acti1.29480754
53MP0004957_abnormal_blastocyst_morpholog1.27816496
54MP0009643_abnormal_urine_homeostasis1.27008415
55MP0003942_abnormal_urinary_system1.26891078
56MP0005275_abnormal_skin_tensile1.24017097
57MP0000598_abnormal_liver_morphology1.22552569
58MP0003693_abnormal_embryo_hatching1.22239801
59MP0000762_abnormal_tongue_morphology1.18794228
60MP0003315_abnormal_perineum_morphology1.17544181
61MP0002234_abnormal_pharynx_morphology1.14671684
62MP0002751_abnormal_autonomic_nervous1.13177036
63MP0008877_abnormal_DNA_methylation1.13047179
64MP0002102_abnormal_ear_morphology1.10758906
65MP0010094_abnormal_chromosome_stability1.08866966
66MP0009053_abnormal_anal_canal1.08471363
67MP0010352_gastrointestinal_tract_polyps1.03302678
68MP0003136_yellow_coat_color1.02941914
69MP0005647_abnormal_sex_gland0.99939214
70MP0009703_decreased_birth_body0.99684605
71MP0009250_abnormal_appendicular_skeleto0.98814367
72* MP0005266_abnormal_metabolism0.98138117
73MP0000432_abnormal_head_morphology0.98103532
74MP0006035_abnormal_mitochondrial_morpho0.97317375
75MP0009384_cardiac_valve_regurgitation0.95979284
76MP0003077_abnormal_cell_cycle0.93660919
77MP0000537_abnormal_urethra_morphology0.93478437
78MP0006072_abnormal_retinal_apoptosis0.93051123
79MP0003935_abnormal_craniofacial_develop0.91745463
80MP0005636_abnormal_mineral_homeostasis0.91632621
81MP0003705_abnormal_hypodermis_morpholog0.91512001
82MP0003123_paternal_imprinting0.91005234
83MP0003283_abnormal_digestive_organ0.90291170
84* MP0009763_increased_sensitivity_to0.90179654
85MP0003566_abnormal_cell_adhesion0.89793154
86MP0002282_abnormal_trachea_morphology0.88891466
87MP0005395_other_phenotype0.88555317
88* MP0005376_homeostasis/metabolism_phenot0.88008845
89MP0003656_abnormal_erythrocyte_physiolo0.87583749
90MP0001177_atelectasis0.87290838
91MP0003861_abnormal_nervous_system0.85103252
92MP0005220_abnormal_exocrine_pancreas0.83872667
93MP0009379_abnormal_foot_pigmentation0.83510868
94MP0004133_heterotaxia0.82294206
95MP0005391_vision/eye_phenotype0.81909111
96MP0000579_abnormal_nail_morphology0.81290107
97MP0001984_abnormal_olfaction0.79777344
98MP0000534_abnormal_ureter_morphology0.78698851
99MP0001849_ear_inflammation0.76785166
100MP0000647_abnormal_sebaceous_gland0.75761435
101MP0002116_abnormal_craniofacial_bone0.74277705
102MP0005670_abnormal_white_adipose0.74207791
103MP0003890_abnormal_embryonic-extraembry0.73831374
104MP0003111_abnormal_nucleus_morphology0.73187057
105MP0008932_abnormal_embryonic_tissue0.73147765
106MP0008057_abnormal_DNA_replication0.72617530
107MP0008058_abnormal_DNA_repair0.72380847
108MP0005197_abnormal_uvea_morphology0.72148919
109MP0001730_embryonic_growth_arrest0.72039713
110MP0005508_abnormal_skeleton_morphology0.71670319
111MP0010030_abnormal_orbit_morphology0.70955330
112MP0002132_abnormal_respiratory_system0.70921793
113MP0002090_abnormal_vision0.70671466
114MP0002295_abnormal_pulmonary_circulatio0.70503202
115MP0003950_abnormal_plasma_membrane0.69577056
116MP0003115_abnormal_respiratory_system0.68746753
117MP0009642_abnormal_blood_homeostasis0.66276961
118* MP0009765_abnormal_xenobiotic_induced0.65059348
119MP0009672_abnormal_birth_weight0.64963460
120MP0001661_extended_life_span0.64344807
121MP0010368_abnormal_lymphatic_system0.63435833
122MP0008469_abnormal_protein_level0.62652370
123MP0001756_abnormal_urination0.61657493
124MP0005084_abnormal_gallbladder_morpholo0.59790095
125MP0000566_synostosis0.58391505
126MP0008007_abnormal_cellular_replicative0.55042996
127MP0001915_intracranial_hemorrhage0.54934385
128MP0000639_abnormal_adrenal_gland0.54827998
129MP0009764_decreased_sensitivity_to0.52500031
130MP0002249_abnormal_larynx_morphology0.51706126
131* MP0008873_increased_physiological_sensi0.45814556
132MP0002136_abnormal_kidney_physiology0.45721087
133MP0001119_abnormal_female_reproductive0.44138642
134MP0001293_anophthalmia0.43126603
135MP0003567_abnormal_fetal_cardiomyocyte0.42588522
136MP0001672_abnormal_embryogenesis/_devel0.42578176
137MP0005380_embryogenesis_phenotype0.42578176
138MP0005023_abnormal_wound_healing0.42411080
139MP0000604_amyloidosis0.41380919
140MP0003221_abnormal_cardiomyocyte_apopto0.41262444
141MP0002111_abnormal_tail_morphology0.41073386
142MP0004782_abnormal_surfactant_physiolog0.40674990
143MP0005666_abnormal_adipose_tissue0.40255003
144MP0002078_abnormal_glucose_homeostasis0.38822893
145MP0001697_abnormal_embryo_size0.38303472
146MP0003119_abnormal_digestive_system0.38299608
147MP0003638_abnormal_response/metabolism_0.37601468
148MP0002254_reproductive_system_inflammat0.37574813
149MP0000350_abnormal_cell_proliferation0.37433476
150MP0003699_abnormal_female_reproductive0.37109975
151MP0001286_abnormal_eye_development0.37045844
152MP0002092_abnormal_eye_morphology0.36893274
153MP0002080_prenatal_lethality0.36106297
154MP0004197_abnormal_fetal_growth/weight/0.35358323
155MP0005248_abnormal_Harderian_gland0.35012913
156MP0000358_abnormal_cell_content/0.34919411
157MP0002697_abnormal_eye_size0.34684757
158MP0002088_abnormal_embryonic_growth/wei0.34264680
159MP0003984_embryonic_growth_retardation0.34029303

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.65497421
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.64996459
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.28863193
4Hypobetalipoproteinemia (HP:0003563)6.24358668
5Deep venous thrombosis (HP:0002625)5.96148617
6Prolonged partial thromboplastin time (HP:0003645)5.23968322
7Xanthomatosis (HP:0000991)4.96307934
8Abnormality of pyrimidine metabolism (HP:0004353)4.59532406
9Hyperglycinemia (HP:0002154)4.56692834
10Hyperammonemia (HP:0001987)4.54823547
11Abnormality of methionine metabolism (HP:0010901)4.44047423
12Hyperlipoproteinemia (HP:0010980)4.39894841
13Hypolipoproteinemia (HP:0010981)4.30632423
14Abnormality of serine family amino acid metabolism (HP:0010894)4.28934552
15Abnormality of glycine metabolism (HP:0010895)4.28934552
16Hyperglycinuria (HP:0003108)4.28846874
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.20904761
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.15046545
19Complement deficiency (HP:0004431)4.11709116
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.89837289
21Ketosis (HP:0001946)3.76445687
22Epidermoid cyst (HP:0200040)3.67911398
23Fat malabsorption (HP:0002630)3.66934852
24Conjugated hyperbilirubinemia (HP:0002908)3.65482007
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.61440359
26Hypoglycemic coma (HP:0001325)3.54185021
27Joint hemorrhage (HP:0005261)3.50235237
28Abnormality of the labia minora (HP:0012880)3.47975278
29Abnormality of fatty-acid metabolism (HP:0004359)3.46891657
30Abnormality of serum amino acid levels (HP:0003112)3.40897367
31Delayed CNS myelination (HP:0002188)3.36158192
32Hypoalphalipoproteinemia (HP:0003233)3.29414750
33Cerebral edema (HP:0002181)3.24817609
34Abnormality of the common coagulation pathway (HP:0010990)3.24027693
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.20033448
36Colon cancer (HP:0003003)3.14446144
37Lethargy (HP:0001254)3.10917784
38Hyperbilirubinemia (HP:0002904)3.00118577
39Abnormality of nucleobase metabolism (HP:0010932)2.98219608
40Dicarboxylic aciduria (HP:0003215)2.97330140
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97330140
42Abnormality of complement system (HP:0005339)2.97202219
43Steatorrhea (HP:0002570)2.95735091
44Abnormality of glycolysis (HP:0004366)2.95411185
45Increased serum pyruvate (HP:0003542)2.95411185
46Spastic diplegia (HP:0001264)2.85031831
47Hypercholesterolemia (HP:0003124)2.84089489
48Abnormality of the intrinsic pathway (HP:0010989)2.80927346
49Metabolic acidosis (HP:0001942)2.75805838
50Septo-optic dysplasia (HP:0100842)2.71113158
51Hepatocellular carcinoma (HP:0001402)2.68361027
52Meckel diverticulum (HP:0002245)2.67804656
53Abnormal lung lobation (HP:0002101)2.67284025
54Hepatoblastoma (HP:0002884)2.64634771
55Ketoacidosis (HP:0001993)2.58866883
56Birth length less than 3rd percentile (HP:0003561)2.53622290
57Abnormality of the ileum (HP:0001549)2.49851558
58Generalized aminoaciduria (HP:0002909)2.46823059
59Bifid tongue (HP:0010297)2.46369456
60Hypochromic microcytic anemia (HP:0004840)2.35112514
61Opisthotonus (HP:0002179)2.29160610
62Premature rupture of membranes (HP:0001788)2.29074485
63Vascular calcification (HP:0004934)2.29074361
64Spontaneous abortion (HP:0005268)2.28377084
65Acute encephalopathy (HP:0006846)2.27965986
66Chromsome breakage (HP:0040012)2.26502046
67Vomiting (HP:0002013)2.26211065
68Nephroblastoma (Wilms tumor) (HP:0002667)2.26034265
69Cortical dysplasia (HP:0002539)2.25707710
70Glycosuria (HP:0003076)2.24065035
71Abnormality of urine glucose concentration (HP:0011016)2.24065035
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23042854
73Hepatic necrosis (HP:0002605)2.22021055
74Irritability (HP:0000737)2.19602428
75Brushfield spots (HP:0001088)2.18404447
76Embryonal renal neoplasm (HP:0011794)2.17589558
77Malnutrition (HP:0004395)2.17574605
78Abnormality of purine metabolism (HP:0004352)2.17563209
79Alkalosis (HP:0001948)2.15207246
80Nausea (HP:0002018)2.13919427
81Oral leukoplakia (HP:0002745)2.13811054
82Proximal tubulopathy (HP:0000114)2.13481437
83Abnormal cartilage morphology (HP:0002763)2.08249774
84Hypoplastic pelvis (HP:0008839)2.08034070
85Coronal craniosynostosis (HP:0004440)2.05783152
86Cholecystitis (HP:0001082)2.04052130
87Abnormal gallbladder physiology (HP:0012438)2.04052130
88Skin nodule (HP:0200036)2.02902001
89Enlarged kidneys (HP:0000105)2.02326944
90Supernumerary spleens (HP:0009799)1.98749877
91Neonatal onset (HP:0003623)1.98248122
92Gout (HP:0001997)1.97159159
93Renal cortical cysts (HP:0000803)1.95986297
94Cardiovascular calcification (HP:0011915)1.95658078
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.94872174
96Hypoglycemic seizures (HP:0002173)1.94574123
97Megaloblastic anemia (HP:0001889)1.94410922
98Pancreatic islet-cell hyperplasia (HP:0004510)1.92759240
99Choanal stenosis (HP:0000452)1.92065123
100Microglossia (HP:0000171)1.91528843
101Esophageal varix (HP:0002040)1.89498826
102Abnormality of chromosome stability (HP:0003220)1.89224437
103Lipid accumulation in hepatocytes (HP:0006561)1.88910695
104Spastic paraparesis (HP:0002313)1.88447987
105Soft skin (HP:0000977)1.88273278
106Increased nuchal translucency (HP:0010880)1.88271732
107Abnormal gallbladder morphology (HP:0012437)1.88268651
108Facial cleft (HP:0002006)1.87163914
109Protrusio acetabuli (HP:0003179)1.84571241
110Ankle contracture (HP:0006466)1.84548571
111Ependymoma (HP:0002888)1.84467411
112Aplasia/Hypoplasia of the breasts (HP:0010311)1.84374287
113Abnormality of vitamin metabolism (HP:0100508)1.81792550
114Stenosis of the external auditory canal (HP:0000402)1.81036791
115Rickets (HP:0002748)1.80612955
116Cholelithiasis (HP:0001081)1.80608298
117Aplasia/Hypoplasia of the sternum (HP:0006714)1.80576878
118Triphalangeal thumb (HP:0001199)1.80352442
119Intestinal atresia (HP:0011100)1.80259259
120Elevated hepatic transaminases (HP:0002910)1.79624914
121Neoplasm of the colon (HP:0100273)1.78113000
122Abnormality of the duodenum (HP:0002246)1.77946846
123Increased muscle lipid content (HP:0009058)1.76842640
124Late onset (HP:0003584)1.76622917
125Pancreatitis (HP:0001733)1.75557317
126Systemic lupus erythematosus (HP:0002725)1.74640496
127Increased serum lactate (HP:0002151)1.74536148
128Multiple enchondromatosis (HP:0005701)1.73981604
129Duodenal stenosis (HP:0100867)1.73310500
130Small intestinal stenosis (HP:0012848)1.73310500
131Acute necrotizing encephalopathy (HP:0006965)1.72622566
132Breast aplasia (HP:0100783)1.70971116
133Lactic acidosis (HP:0003128)1.70961987
134Abnormality of dentin (HP:0010299)1.69002083
135Reticulocytopenia (HP:0001896)1.68734655
136Anophthalmia (HP:0000528)1.67608535
137Hepatocellular necrosis (HP:0001404)1.67328637
138Myocardial infarction (HP:0001658)1.66159028
139Methylmalonic aciduria (HP:0012120)1.65971547
140CNS demyelination (HP:0007305)1.65851297
141Absent septum pellucidum (HP:0001331)1.65700256
142Renal Fanconi syndrome (HP:0001994)1.65643614
143Increased intramyocellular lipid droplets (HP:0012240)1.65251284
144Acanthocytosis (HP:0001927)1.63892565
145Hypoplastic female external genitalia (HP:0012815)1.63843593
146Neoplasm of the adrenal gland (HP:0100631)1.63458417
147Increased hepatocellular lipid droplets (HP:0006565)1.63285816
148Methylmalonic acidemia (HP:0002912)1.61334640
149Broad foot (HP:0001769)1.60710422
150Myelomeningocele (HP:0002475)1.60175110
151Bilateral microphthalmos (HP:0007633)1.59196648
152Abnormality of the preputium (HP:0100587)1.58545157
153Rhabdomyosarcoma (HP:0002859)1.56637428
154Neonatal short-limb short stature (HP:0008921)1.54715182
155Scrotal hypoplasia (HP:0000046)1.52899940
156Medulloblastoma (HP:0002885)1.52274295
157Breast hypoplasia (HP:0003187)1.50982402
158Partial duplication of the phalanx of hand (HP:0009999)1.46994045
159Preaxial foot polydactyly (HP:0001841)1.46546912
160Partial duplication of thumb phalanx (HP:0009944)1.46417645
161Abnormality of the septum pellucidum (HP:0007375)1.45290855
162Labial hypoplasia (HP:0000066)1.45246297
163Pterygium (HP:0001059)1.44688255
164Chronic hepatic failure (HP:0100626)1.44077541
165Hemivertebrae (HP:0002937)1.43548071
166Renal hypoplasia (HP:0000089)1.43368265
167Generalized hypotonia (HP:0001290)1.43120904
168Vaginal atresia (HP:0000148)1.43001623
169Broad metatarsal (HP:0001783)1.42950210
170Biliary tract neoplasm (HP:0100574)1.42572650
171Gonadotropin excess (HP:0000837)1.42454621
172Ovarian neoplasm (HP:0100615)1.41768139
173Abnormality of the clitoris (HP:0000056)1.41446704
174Maternal diabetes (HP:0009800)1.40843774
175Abnormal mitochondria in muscle tissue (HP:0008316)1.40253448
176Macrocytic anemia (HP:0001972)1.39666256
177Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.39444691
178Genital tract atresia (HP:0001827)1.39315434
179Dental crowding (HP:0000678)1.38227824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.88626259
2BUB13.69903768
3EIF2AK12.76507346
4WEE12.64810796
5TESK22.56051788
6ERBB42.48116160
7CDC72.43431263
8PBK2.38880157
9MKNK22.34143845
10TLK12.23791715
11NME22.11335097
12ACVR1B2.11156665
13TRIM282.08807252
14TTK1.99231358
15TNIK1.92518967
16VRK21.89821864
17STK38L1.88788231
18STK161.81274346
19SRPK11.76022795
20FGFR41.73635767
21NEK11.69440288
22FLT31.65663371
23KDR1.64697749
24EIF2AK31.54343671
25TAF11.51281044
26PLK41.44773847
27ABL21.41692416
28VRK11.39701711
29SIK11.36100023
30NEK91.34849757
31LATS11.32920043
32BMPR1B1.31863277
33RPS6KB21.30272274
34PLK11.29499831
35TGFBR11.24733095
36EPHA21.22699286
37CDK71.21059521
38PDK21.19597911
39DYRK21.18513422
40PLK21.16751075
41MET1.15478500
42MAPK111.14225053
43FGFR11.12840187
44MAP3K81.12450736
45AURKA1.12131277
46AURKB1.10982618
47DYRK31.09707282
48PASK1.07244903
49CSNK1G31.06198011
50ERN11.04705562
51NME11.04235353
52CASK1.04088763
53PDGFRA1.03434055
54BRSK11.00413859
55MAP3K110.95754830
56CSNK1G10.94957264
57CDK40.94230039
58ERBB30.89841966
59TSSK60.89387985
60MAP2K30.87077677
61PLK30.86391604
62PAK40.85655758
63NEK20.85474746
64PNCK0.83644768
65TAOK20.83554210
66FGFR20.81550208
67BRSK20.80267972
68ATR0.80008987
69STK100.79159951
70MELK0.78198815
71STK30.76055242
72PIK3CG0.75592774
73MKNK10.73922167
74CHEK20.72128700
75CDK60.71789069
76CSNK2A20.71708253
77MST40.71238708
78BRAF0.71134201
79ALK0.70517296
80CSNK2A10.70364952
81BCR0.70123237
82WNK30.68449924
83MAP3K30.67648900
84STK40.66628966
85MAP4K20.65480822
86EPHA40.64625309
87CDK190.64029466
88MAP3K120.60594334
89MAP2K20.60519344
90PKN20.60367021
91CSNK1A1L0.60170301
92PAK20.59879291
93ERBB20.59791058
94DDR20.58247236
95LATS20.56689146
96MAP2K60.55802031
97EIF2AK20.55015994
98TYK20.53578220
99CHEK10.52778357
100MAP3K40.51892973
101MAP3K100.51228730
102LIMK10.50403747
103DMPK0.48654932
104RPS6KA40.48602526
105STK390.48427396
106MST1R0.47817064
107GRK60.46975876
108TIE10.46453606
109OXSR10.44212289
110NLK0.42554809
111CDK180.42534194
112ZAK0.42301161
113MYLK0.41658931
114CSNK1G20.41598758
115MAP3K60.41251589
116PRKDC0.40776842
117PIM10.40567988
118CDK10.38606305
119NUAK10.38590278
120LRRK20.38522184
121CDK30.37683665
122NTRK10.37635633
123ROCK20.37468442
124CDK150.36907545
125CDK140.36873491
126MAPK40.36800867
127PAK10.36422382
128RPS6KA50.36345390
129PRKCE0.36232591
130CDK11A0.35052803
131ATM0.34245892
132MINK10.34134145
133PTK20.33648083
134CDK80.32942848
135GSK3A0.32752895
136CSNK1E0.32475232
137PRKCG0.32357261
138BRD40.32316174
139CDK20.32227214
140PRKCI0.31129921
141EPHB20.30848100
142TAOK30.29927380

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.64667588
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.97093960
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.76913947
4Nitrogen metabolism_Homo sapiens_hsa009102.70404047
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68264489
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.55734289
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39440205
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38285703
9Arginine biosynthesis_Homo sapiens_hsa002202.37813692
10Tryptophan metabolism_Homo sapiens_hsa003802.27414925
11* Fatty acid degradation_Homo sapiens_hsa000712.17247578
12Complement and coagulation cascades_Homo sapiens_hsa046102.06808991
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05570402
14Peroxisome_Homo sapiens_hsa041461.97597367
15Butanoate metabolism_Homo sapiens_hsa006501.96166950
16Propanoate metabolism_Homo sapiens_hsa006401.96005538
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95775962
18* Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93504804
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.88722535
20One carbon pool by folate_Homo sapiens_hsa006701.88064560
21* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76502628
22* Chemical carcinogenesis_Homo sapiens_hsa052041.75290891
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74026417
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.72713874
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68865669
26Selenocompound metabolism_Homo sapiens_hsa004501.67994458
27Histidine metabolism_Homo sapiens_hsa003401.64476911
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.63318092
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62582595
30Pyruvate metabolism_Homo sapiens_hsa006201.60039823
31Biosynthesis of amino acids_Homo sapiens_hsa012301.59251994
32Fatty acid metabolism_Homo sapiens_hsa012121.59251796
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58821131
34beta-Alanine metabolism_Homo sapiens_hsa004101.57378133
35Folate biosynthesis_Homo sapiens_hsa007901.56837870
36Fatty acid elongation_Homo sapiens_hsa000621.49245941
37* Retinol metabolism_Homo sapiens_hsa008301.43484302
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.42179796
39PPAR signaling pathway_Homo sapiens_hsa033201.42025110
40* Carbon metabolism_Homo sapiens_hsa012001.40442845
41Phenylalanine metabolism_Homo sapiens_hsa003601.36232393
42Steroid biosynthesis_Homo sapiens_hsa001001.34968644
43Sulfur relay system_Homo sapiens_hsa041221.34825907
44Sulfur metabolism_Homo sapiens_hsa009201.30171574
45Caffeine metabolism_Homo sapiens_hsa002321.28106387
46* Tyrosine metabolism_Homo sapiens_hsa003501.27865265
47DNA replication_Homo sapiens_hsa030301.23057089
48Arginine and proline metabolism_Homo sapiens_hsa003301.15403546
49Glutathione metabolism_Homo sapiens_hsa004801.14182583
50Mismatch repair_Homo sapiens_hsa034301.12089389
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11447975
52Staphylococcus aureus infection_Homo sapiens_hsa051501.09601853
53Proteasome_Homo sapiens_hsa030501.06540227
54Vitamin B6 metabolism_Homo sapiens_hsa007501.06106601
55Basal cell carcinoma_Homo sapiens_hsa052170.98422271
56Starch and sucrose metabolism_Homo sapiens_hsa005000.95880608
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94962949
58Ribosome_Homo sapiens_hsa030100.94654754
59Fat digestion and absorption_Homo sapiens_hsa049750.92282107
60Bile secretion_Homo sapiens_hsa049760.86301243
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85904144
62mRNA surveillance pathway_Homo sapiens_hsa030150.85890901
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85699790
64Pentose phosphate pathway_Homo sapiens_hsa000300.85432169
65* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84361830
66Pyrimidine metabolism_Homo sapiens_hsa002400.83361508
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83350443
68Hippo signaling pathway_Homo sapiens_hsa043900.81043807
69Hedgehog signaling pathway_Homo sapiens_hsa043400.77354221
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72382943
71TGF-beta signaling pathway_Homo sapiens_hsa043500.71865752
72RNA polymerase_Homo sapiens_hsa030200.71076008
73Adherens junction_Homo sapiens_hsa045200.70311598
74Vitamin digestion and absorption_Homo sapiens_hsa049770.70058968
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68238055
76p53 signaling pathway_Homo sapiens_hsa041150.67023220
77* Metabolic pathways_Homo sapiens_hsa011000.66942369
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.66757906
79ABC transporters_Homo sapiens_hsa020100.65693904
80Lysine degradation_Homo sapiens_hsa003100.62661404
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60251005
82Nucleotide excision repair_Homo sapiens_hsa034200.59462299
83Oocyte meiosis_Homo sapiens_hsa041140.59045240
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58790188
85Wnt signaling pathway_Homo sapiens_hsa043100.58170878
86Alzheimers disease_Homo sapiens_hsa050100.58139422
87ECM-receptor interaction_Homo sapiens_hsa045120.57569341
88Base excision repair_Homo sapiens_hsa034100.55555593
89Homologous recombination_Homo sapiens_hsa034400.53970483
90Spliceosome_Homo sapiens_hsa030400.52879552
91Tight junction_Homo sapiens_hsa045300.50603636
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49950324
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49108777
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47099874
95RNA transport_Homo sapiens_hsa030130.44339250
96Linoleic acid metabolism_Homo sapiens_hsa005910.44230211
97Glycerolipid metabolism_Homo sapiens_hsa005610.44143644
98Oxidative phosphorylation_Homo sapiens_hsa001900.40592045
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40545999
100Systemic lupus erythematosus_Homo sapiens_hsa053220.39842070
101N-Glycan biosynthesis_Homo sapiens_hsa005100.38634911
102Parkinsons disease_Homo sapiens_hsa050120.36166061
103Fructose and mannose metabolism_Homo sapiens_hsa000510.33947854
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31125447
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27600028
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26880173
107Cell cycle_Homo sapiens_hsa041100.26252857
108Fatty acid biosynthesis_Homo sapiens_hsa000610.24678079
109Galactose metabolism_Homo sapiens_hsa000520.24581488
110Non-homologous end-joining_Homo sapiens_hsa034500.24197840
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22483597
112Purine metabolism_Homo sapiens_hsa002300.22028038
113RNA degradation_Homo sapiens_hsa030180.21360153
114Protein export_Homo sapiens_hsa030600.18907101
115Basal transcription factors_Homo sapiens_hsa030220.18836761
116Huntingtons disease_Homo sapiens_hsa050160.18225319
117Fanconi anemia pathway_Homo sapiens_hsa034600.16488530
118Arachidonic acid metabolism_Homo sapiens_hsa005900.15451775

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »