ADH5P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive T cell selection (GO:0043368)5.93571380
2T cell migration (GO:0072678)5.50569394
3positive regulation of tolerance induction (GO:0002645)5.24105252
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.21933183
5negative regulation of execution phase of apoptosis (GO:1900118)5.21146549
6viral transcription (GO:0019083)5.18738750
7translational termination (GO:0006415)5.10784724
8negative T cell selection (GO:0043383)4.90211116
9regulation of isotype switching to IgG isotypes (GO:0048302)4.85406804
10mitochondrial calcium ion transport (GO:0006851)4.47046901
11regulation of T cell tolerance induction (GO:0002664)4.46247895
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.40821789
13cotranslational protein targeting to membrane (GO:0006613)4.29773033
14alpha-beta T cell differentiation (GO:0046632)4.25591988
15protein targeting to ER (GO:0045047)4.24080388
16V(D)J recombination (GO:0033151)4.21919728
17chaperone-mediated protein transport (GO:0072321)4.19307280
18T cell selection (GO:0045058)4.16268862
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.08424048
20tolerance induction (GO:0002507)4.07163620
21viral life cycle (GO:0019058)4.03680716
22ribosomal small subunit biogenesis (GO:0042274)4.00123805
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.96160094
24translational elongation (GO:0006414)3.95710634
25cellular protein complex disassembly (GO:0043624)3.93775355
26protein localization to endoplasmic reticulum (GO:0070972)3.86164136
27mast cell activation (GO:0045576)3.85489022
28thymic T cell selection (GO:0045061)3.63933075
29regulation of tolerance induction (GO:0002643)3.61936740
30respiratory tube development (GO:0030323)3.56231875
31regulation of T cell receptor signaling pathway (GO:0050856)3.53280188
32alpha-beta T cell activation (GO:0046631)3.53171927
33T cell receptor signaling pathway (GO:0050852)3.52417865
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50392446
35positive regulation of interleukin-4 production (GO:0032753)3.50134245
36negative thymic T cell selection (GO:0045060)3.48801266
37endoderm formation (GO:0001706)3.45758871
38T cell differentiation (GO:0030217)3.43789229
39negative regulation of calcium ion transport into cytosol (GO:0010523)3.39242344
40translational initiation (GO:0006413)3.39184804
41embryonic hemopoiesis (GO:0035162)3.39121724
42regulation of chronic inflammatory response (GO:0002676)3.38298044
43regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.36778232
44protein complex disassembly (GO:0043241)3.34624253
45positive regulation of cAMP-mediated signaling (GO:0043950)3.33347530
46kidney morphogenesis (GO:0060993)3.32854942
47photoreceptor cell maintenance (GO:0045494)3.31894602
48response to pheromone (GO:0019236)3.28673086
49single strand break repair (GO:0000012)3.26912188
50positive regulation of granulocyte differentiation (GO:0030854)3.23880982
51positive regulation by host of viral transcription (GO:0043923)3.23299400
52negative regulation of cAMP-mediated signaling (GO:0043951)3.21879282
53regulation of interleukin-2 biosynthetic process (GO:0045076)3.21078076
54positive thymic T cell selection (GO:0045059)3.17513262
55blood vessel maturation (GO:0001955)3.15603939
56macromolecular complex disassembly (GO:0032984)3.12592639
57cardiovascular system development (GO:0072358)3.11331355
58positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.09077116
59regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.09077116
60positive regulation of T cell cytokine production (GO:0002726)3.06107027
61ribosomal small subunit assembly (GO:0000028)3.05413271
62regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.05244730
63positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.05244730
64establishment of protein localization to mitochondrial membrane (GO:0090151)3.03809093
65retina layer formation (GO:0010842)3.02875427
66viral protein processing (GO:0019082)3.02245115
67negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.02145916
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01806402
69regulation of B cell receptor signaling pathway (GO:0050855)3.00889081
70regulation of interleukin-4 production (GO:0032673)3.00810402
71positive regulation of interleukin-2 production (GO:0032743)3.00029471
72regulation of regulatory T cell differentiation (GO:0045589)2.94614934
73interferon-gamma production (GO:0032609)2.94368971
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92959355
75nuclear-transcribed mRNA catabolic process (GO:0000956)2.90466614
76regulation of T cell cytokine production (GO:0002724)2.88365509
77positive regulation of uterine smooth muscle contraction (GO:0070474)2.87684524
78mRNA catabolic process (GO:0006402)2.86172912
79rRNA methylation (GO:0031167)2.85257912
80metanephric tubule development (GO:0072170)2.83014619
81metanephric nephron tubule development (GO:0072234)2.83014619
82anatomical structure regression (GO:0060033)2.82555479
83regulation of mesoderm development (GO:2000380)2.81872507
84ectoderm development (GO:0007398)2.79191236
85lung epithelium development (GO:0060428)2.75939405
86axoneme assembly (GO:0035082)2.74202008
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.70399983
88negative regulation of translation, ncRNA-mediated (GO:0040033)2.70399983
89regulation of translation, ncRNA-mediated (GO:0045974)2.70399983
90antigen receptor-mediated signaling pathway (GO:0050851)2.70352932
91protein targeting to membrane (GO:0006612)2.69695104
92embryonic body morphogenesis (GO:0010172)2.69115508
93positive regulation of mRNA 3-end processing (GO:0031442)2.68048284
94regulation of cAMP-mediated signaling (GO:0043949)2.67839276
95hypothalamus development (GO:0021854)2.64815622
96genitalia morphogenesis (GO:0035112)2.63007451
97T cell activation (GO:0042110)2.62168215
98CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.60529020
99protein deneddylation (GO:0000338)2.60245627
100positive regulation of alpha-beta T cell proliferation (GO:0046641)2.59521687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.69413339
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.83633056
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.64010356
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.37396587
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88792503
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.44983394
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78438750
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74187213
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.51038208
10RUNX_20019798_ChIP-Seq_JUKART_Human2.43217111
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.38817639
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35139197
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34320166
14TAF15_26573619_Chip-Seq_HEK293_Human2.22372878
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16355962
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.00043167
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85537940
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.84338014
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83463635
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.80028888
21VDR_22108803_ChIP-Seq_LS180_Human1.75417526
22ZNF274_21170338_ChIP-Seq_K562_Hela1.75399104
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.72837480
24VDR_23849224_ChIP-Seq_CD4+_Human1.70587477
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70284548
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66127947
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64598676
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63241728
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60804344
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.54745926
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.54745926
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.54745926
33MYB_26560356_Chip-Seq_TH2_Human1.52328694
34FUS_26573619_Chip-Seq_HEK293_Human1.48215876
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45675927
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45536348
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43667696
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43667696
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.40918375
40EWS_26573619_Chip-Seq_HEK293_Human1.36149735
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34791144
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31127323
43GATA3_26560356_Chip-Seq_TH2_Human1.28028165
44P300_19829295_ChIP-Seq_ESCs_Human1.26645370
45PRDM14_20953172_ChIP-Seq_ESCs_Human1.26601987
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26341091
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24626527
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21988714
49GATA3_27048872_Chip-Seq_THYMUS_Human1.19558715
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18368771
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.15060826
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15028581
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12502627
54TCF4_22108803_ChIP-Seq_LS180_Human1.11992204
55ELK1_19687146_ChIP-ChIP_HELA_Human1.11476551
56IRF1_19129219_ChIP-ChIP_H3396_Human1.09807371
57STAT3_23295773_ChIP-Seq_U87_Human1.09680005
58TP53_22573176_ChIP-Seq_HFKS_Human1.08216131
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.07207010
60GBX2_23144817_ChIP-Seq_PC3_Human1.06287820
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06093878
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03333948
63FOXP3_21729870_ChIP-Seq_TREG_Human1.02234816
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00033392
65FLI1_21867929_ChIP-Seq_TH2_Mouse0.97835398
66SMAD4_21741376_ChIP-Seq_EPCs_Human0.96442211
67BCAT_22108803_ChIP-Seq_LS180_Human0.95826165
68CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95676954
69MYB_26560356_Chip-Seq_TH1_Human0.95563787
70TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.93670758
71E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93422787
72NFE2_27457419_Chip-Seq_LIVER_Mouse0.92458640
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91326227
74CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90825287
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89904464
76YY1_21170310_ChIP-Seq_MESCs_Mouse0.89322395
77TCF4_23295773_ChIP-Seq_U87_Human0.88665985
78CIITA_25753668_ChIP-Seq_RAJI_Human0.88301027
79SMAD3_21741376_ChIP-Seq_EPCs_Human0.87005356
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86710321
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85883964
82GATA3_26560356_Chip-Seq_TH1_Human0.85280103
83SMAD4_21799915_ChIP-Seq_A2780_Human0.84018179
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82699775
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82482437
86EZH2_22144423_ChIP-Seq_EOC_Human0.82210846
87RXR_22108803_ChIP-Seq_LS180_Human0.81813247
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81601995
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81323982
90JUN_21703547_ChIP-Seq_K562_Human0.79141916
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77749861
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.77250801
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77243629
94AR_20517297_ChIP-Seq_VCAP_Human0.77007017
95ER_23166858_ChIP-Seq_MCF-7_Human0.76538020
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76335883
97SOX2_19829295_ChIP-Seq_ESCs_Human0.75884902
98NANOG_19829295_ChIP-Seq_ESCs_Human0.75884902
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74924868
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.74917083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.18405141
2MP0002102_abnormal_ear_morphology4.22939287
3MP0002009_preneoplasia4.15353045
4MP0006072_abnormal_retinal_apoptosis3.45467375
5MP0003787_abnormal_imprinting3.25398125
6MP0003763_abnormal_thymus_physiology3.17756697
7MP0005671_abnormal_response_to3.09793162
8MP0008877_abnormal_DNA_methylation3.04251122
9MP0008995_early_reproductive_senescence3.01070806
10MP0003786_premature_aging2.54669650
11MP0002166_altered_tumor_susceptibility2.50315535
12MP0003866_abnormal_defecation2.49875815
13MP0003045_fibrosis2.22385679
14MP0009379_abnormal_foot_pigmentation2.18680893
15MP0001873_stomach_inflammation2.11783563
16MP0003283_abnormal_digestive_organ2.06865807
17MP0005253_abnormal_eye_physiology1.94467009
18MP0004142_abnormal_muscle_tone1.90817161
19MP0005075_abnormal_melanosome_morpholog1.90680711
20MP0000703_abnormal_thymus_morphology1.90409479
21MP0002876_abnormal_thyroid_physiology1.89336927
22MP0001968_abnormal_touch/_nociception1.88566397
23MP0002653_abnormal_ependyma_morphology1.82764917
24MP0003195_calcinosis1.73126261
25MP0003567_abnormal_fetal_cardiomyocyte1.70342118
26MP0002006_tumorigenesis1.68811546
27MP0009384_cardiac_valve_regurgitation1.60351038
28MP0003890_abnormal_embryonic-extraembry1.60031141
29MP0005551_abnormal_eye_electrophysiolog1.56267866
30MP0002168_other_aberrant_phenotype1.46561469
31MP0005377_hearing/vestibular/ear_phenot1.31347288
32MP0003878_abnormal_ear_physiology1.31347288
33MP0001879_abnormal_lymphatic_vessel1.29500164
34MP0003300_gastrointestinal_ulcer1.29320154
35MP0008004_abnormal_stomach_pH1.22948823
36MP0004134_abnormal_chest_morphology1.21971989
37MP0009333_abnormal_splenocyte_physiolog1.20597040
38MP0001529_abnormal_vocalization1.19467772
39MP0002405_respiratory_system_inflammati1.18819267
40MP0009785_altered_susceptibility_to1.15816631
41MP0006054_spinal_hemorrhage1.12561516
42MP0001293_anophthalmia1.11894094
43MP0003121_genomic_imprinting1.10967900
44MP0006292_abnormal_olfactory_placode1.10612125
45MP0002398_abnormal_bone_marrow1.10314020
46MP0008961_abnormal_basal_metabolism1.08300469
47MP0001286_abnormal_eye_development1.04016163
48MP0005451_abnormal_body_composition1.03889765
49MP0001663_abnormal_digestive_system1.03626455
50MP0002736_abnormal_nociception_after1.01864251
51MP0005379_endocrine/exocrine_gland_phen1.00393518
52MP0001851_eye_inflammation0.99635868
53MP0000689_abnormal_spleen_morphology0.99632793
54MP0005646_abnormal_pituitary_gland0.99581345
55MP0005391_vision/eye_phenotype0.99303305
56MP0003448_altered_tumor_morphology0.99224126
57MP0001800_abnormal_humoral_immune0.99050944
58MP0005195_abnormal_posterior_eye0.98338131
59MP0000716_abnormal_immune_system0.97744263
60MP0002722_abnormal_immune_system0.94286413
61MP0010030_abnormal_orbit_morphology0.91887939
62MP0003806_abnormal_nucleotide_metabolis0.85783355
63MP0004924_abnormal_behavior0.85690497
64MP0005386_behavior/neurological_phenoty0.85690497
65MP0002163_abnormal_gland_morphology0.83497238
66MP0002933_joint_inflammation0.82610214
67MP0002272_abnormal_nervous_system0.80375067
68MP0004381_abnormal_hair_follicle0.80265543
69MP0000372_irregular_coat_pigmentation0.78490971
70MP0006082_CNS_inflammation0.78420387
71MP0002420_abnormal_adaptive_immunity0.77189355
72MP0000685_abnormal_immune_system0.75630189
73MP0001984_abnormal_olfaction0.75223519
74MP0001764_abnormal_homeostasis0.75170874
75MP0008789_abnormal_olfactory_epithelium0.74721560
76MP0002723_abnormal_immune_serum0.74588444
77MP0000470_abnormal_stomach_morphology0.73488683
78MP0001666_abnormal_nutrient_absorption0.71576849
79MP0001819_abnormal_immune_cell0.71245529
80MP0002429_abnormal_blood_cell0.70693307
81MP0005395_other_phenotype0.69993240
82MP0002019_abnormal_tumor_incidence0.69859375
83MP0003315_abnormal_perineum_morphology0.69699675
84MP0002752_abnormal_somatic_nervous0.68020442
85MP0001188_hyperpigmentation0.67214616
86MP0002067_abnormal_sensory_capabilities0.67196044
87MP0003868_abnormal_feces_composition0.65821490
88MP0002160_abnormal_reproductive_system0.65312095
89MP0000778_abnormal_nervous_system0.65107662
90MP0000465_gastrointestinal_hemorrhage0.65071317
91MP0002234_abnormal_pharynx_morphology0.64899612
92MP0002733_abnormal_thermal_nociception0.64636690
93MP0004957_abnormal_blastocyst_morpholog0.63647663
94MP0005266_abnormal_metabolism0.61749393
95MP0009115_abnormal_fat_cell0.61231404
96MP0005387_immune_system_phenotype0.58594923
97MP0001790_abnormal_immune_system0.58594923
98MP0004808_abnormal_hematopoietic_stem0.57917193
99MP0005000_abnormal_immune_tolerance0.56760514
100MP0000631_abnormal_neuroendocrine_gland0.56659612

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.31227638
2T lymphocytopenia (HP:0005403)3.99369276
3Anhidrosis (HP:0000970)3.79026808
4Posterior subcapsular cataract (HP:0007787)3.40813433
5Abnormality of T cell number (HP:0011839)3.39826505
6Hypoplastic iliac wings (HP:0002866)3.36405144
7Thyroiditis (HP:0100646)3.35018995
8Hypoplastic pelvis (HP:0008839)3.28880458
9Ulnar claw (HP:0001178)3.18026064
10Chronic hepatic failure (HP:0100626)3.17810801
11Attenuation of retinal blood vessels (HP:0007843)3.13658738
12IgM deficiency (HP:0002850)3.04077142
13Abnormality of DNA repair (HP:0003254)3.03748757
14Stomatitis (HP:0010280)2.88684538
15Abnormality of the nasal septum (HP:0000419)2.83032131
16Abnormal rod and cone electroretinograms (HP:0008323)2.81051224
17Medial flaring of the eyebrow (HP:0010747)2.79385919
18Autoimmune hemolytic anemia (HP:0001890)2.68519222
19Intestinal atresia (HP:0011100)2.67986181
20Dyschromatopsia (HP:0007641)2.62624934
21Decreased central vision (HP:0007663)2.61635223
22Abnormal drinking behavior (HP:0030082)2.60136856
23Polydipsia (HP:0001959)2.60136856
24True hermaphroditism (HP:0010459)2.54634110
25Entropion (HP:0000621)2.54222434
26Thickened calvaria (HP:0002684)2.50759988
27Abnormality of the phalanges of the 2nd finger (HP:0009541)2.49828016
28Renal Fanconi syndrome (HP:0001994)2.45467576
29Reduced subcutaneous adipose tissue (HP:0003758)2.43734946
30Lymphopenia (HP:0001888)2.41114977
31Constricted visual fields (HP:0001133)2.40576951
32Prominent metopic ridge (HP:0005487)2.40264390
33Abnormality of midbrain morphology (HP:0002418)2.39838660
34Molar tooth sign on MRI (HP:0002419)2.39838660
35Abnormality of the phalanges of the 5th finger (HP:0004213)2.39558457
36Subcapsular cataract (HP:0000523)2.36538999
37Poor coordination (HP:0002370)2.33644453
38Dry hair (HP:0011359)2.31079908
39Short middle phalanx of the 5th finger (HP:0004220)2.28068977
40Severe combined immunodeficiency (HP:0004430)2.27494256
41Abnormality of the vocal cords (HP:0008777)2.26992607
42Pancreatic cysts (HP:0001737)2.26971370
43Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.25504047
44IgG deficiency (HP:0004315)2.25098805
45Narrow palate (HP:0000189)2.25078332
46Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.22755624
47Median cleft lip (HP:0000161)2.20439598
48Pancreatic fibrosis (HP:0100732)2.18054412
49Volvulus (HP:0002580)2.17078529
50Congenital stationary night blindness (HP:0007642)2.14744464
51Abnormality of cells of the erythroid lineage (HP:0012130)2.13930904
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12987540
53Hypophosphatemic rickets (HP:0004912)2.12658662
54Abnormality of the metopic suture (HP:0005556)2.11794720
55Congenital primary aphakia (HP:0007707)2.11780157
56Polyuria (HP:0000103)2.10006794
57Delayed puberty (HP:0000823)2.08236544
58Colon cancer (HP:0003003)2.05291971
59Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.04618337
60Failure to thrive in infancy (HP:0001531)2.04241526
61Abolished electroretinogram (ERG) (HP:0000550)2.03803830
62Hyperglycinemia (HP:0002154)1.99285000
63Gait imbalance (HP:0002141)1.99182272
64Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97641743
65Tubulointerstitial nephritis (HP:0001970)1.96632096
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93948989
67Abnormality of alanine metabolism (HP:0010916)1.93948989
68Hyperalaninemia (HP:0003348)1.93948989
69Joint swelling (HP:0001386)1.92071330
70Abnormality of cells of the lymphoid lineage (HP:0012140)1.90880172
71Broad ribs (HP:0000885)1.90628263
72Abnormality of the parietal bone (HP:0002696)1.90570725
73Central scotoma (HP:0000603)1.89900127
74Macrocytic anemia (HP:0001972)1.89367105
75Spontaneous hematomas (HP:0007420)1.86638592
76Clumsiness (HP:0002312)1.86488585
77Abnormality of hair growth rate (HP:0011363)1.86362573
78Slow-growing hair (HP:0002217)1.86362573
79Spondylolisthesis (HP:0003302)1.85573883
80Severe visual impairment (HP:0001141)1.84218891
81Abnormality of the costochondral junction (HP:0000919)1.84185890
82Nephrogenic diabetes insipidus (HP:0009806)1.83557738
83Abnormal auditory evoked potentials (HP:0006958)1.83393333
84Abnormality of T cells (HP:0002843)1.83082468
85Type I diabetes mellitus (HP:0100651)1.82711723
86Abnormal mitochondria in muscle tissue (HP:0008316)1.82245121
87Neonatal respiratory distress (HP:0002643)1.81308947
88Abnormality of binocular vision (HP:0011514)1.80642434
89Diplopia (HP:0000651)1.80642434
90Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78730083
91Abnormality of the renal cortex (HP:0011035)1.78099151
92Metaphyseal dysplasia (HP:0100255)1.77954220
93Hypokalemia (HP:0002900)1.77718765
94Wide intermamillary distance (HP:0006610)1.76698929
95Hypoproteinemia (HP:0003075)1.75832424
96Bony spicule pigmentary retinopathy (HP:0007737)1.75028648
97Hypoplasia of the thymus (HP:0000778)1.74573869
98Abnormality of eosinophils (HP:0001879)1.74343331
99Pancytopenia (HP:0001876)1.73752518
100Abnormality of the wing of the ilium (HP:0011867)1.72959458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK23.97090740
2MAP4K13.96253355
3AKT33.94947147
4TXK3.42413293
5CASK3.15227715
6NLK2.77317579
7SCYL22.74364481
8MAP3K102.56405891
9KDR2.51786717
10TLK12.27421390
11TEC2.03911756
12ITK1.96844566
13FRK1.90796006
14VRK11.78960156
15GRK61.76108342
16STK161.64033271
17CAMK1D1.59538677
18TYRO31.58625152
19CAMKK11.56876274
20BTK1.48226874
21ADRBK21.47571668
22MAP3K91.44126568
23MST41.39905818
24ACVR1B1.32621182
25NUAK11.30479339
26NME21.26968768
27PIK3CG1.26385823
28ZAK1.25963367
29TESK21.16114715
30TNIK1.14295773
31TRIM281.13114639
32PLK41.10052967
33PRKCQ1.08598066
34MKNK21.07096119
35PRKCH1.06887466
36SGK21.03513463
37WNK31.02381627
38CAMK1G1.01066447
39MAP3K120.99408714
40CAMK40.98853178
41CAMK10.94308611
42TGFBR20.93782277
43CDK30.93099060
44MAP3K40.91275340
45BRSK20.90266277
46SYK0.89544868
47CSNK1G10.85415314
48HIPK20.81571289
49NTRK20.77699615
50BMPR1B0.77097299
51LCK0.75604277
52CDK60.73527316
53PAK30.73030796
54ADRBK10.71561678
55YES10.70236546
56EIF2AK30.67667795
57BRD40.65113471
58MAP4K20.65047591
59DYRK1B0.64379302
60WNK10.63154267
61MAPKAPK30.61600595
62MAP3K130.59361327
63FLT30.56955753
64SGK2230.55345907
65SGK4940.55345907
66NTRK30.55059858
67NEK60.54200892
68IKBKE0.53308200
69PLK30.51292137
70STK30.50861282
71ZAP700.50149518
72PASK0.49949907
73ARAF0.49685893
74TAOK30.49499472
75STK240.48896457
76ATR0.48247597
77VRK20.48164154
78WNK40.47908569
79PLK20.46862074
80CSNK1G20.45798315
81MAPK70.45457296
82TAF10.44332094
83CSNK1G30.43717892
84DYRK1A0.42566241
85PIM10.42018203
86INSRR0.39918304
87UHMK10.38923426
88CAMK2A0.37759453
89CDK90.36122852
90AURKB0.35046992
91MAPK130.34133999
92MYLK0.33458861
93PRKG10.32675744
94ABL10.31672888
95CSNK1A1L0.30799667
96TIE10.29101173
97MOS0.29088270
98HCK0.27880059
99NME10.26537255
100MAPK30.26321494

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.50917452
2Primary immunodeficiency_Homo sapiens_hsa053405.43345424
3T cell receptor signaling pathway_Homo sapiens_hsa046603.67248771
4RNA polymerase_Homo sapiens_hsa030202.74047267
5Basal transcription factors_Homo sapiens_hsa030222.70466078
6Proteasome_Homo sapiens_hsa030502.58906695
7Protein export_Homo sapiens_hsa030602.29239677
8Regulation of autophagy_Homo sapiens_hsa041401.99581964
9Colorectal cancer_Homo sapiens_hsa052101.90830418
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80961426
11RNA degradation_Homo sapiens_hsa030181.78987310
12Selenocompound metabolism_Homo sapiens_hsa004501.62905106
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58376311
14Phototransduction_Homo sapiens_hsa047441.51236842
15Measles_Homo sapiens_hsa051621.48879732
16Hematopoietic cell lineage_Homo sapiens_hsa046401.48202899
17Oxidative phosphorylation_Homo sapiens_hsa001901.44819262
18Wnt signaling pathway_Homo sapiens_hsa043101.37168460
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34742006
20Basal cell carcinoma_Homo sapiens_hsa052171.31805030
21Huntingtons disease_Homo sapiens_hsa050161.30243792
22Homologous recombination_Homo sapiens_hsa034401.24018340
23Nucleotide excision repair_Homo sapiens_hsa034201.22599954
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22573345
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20678705
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.19530748
27Collecting duct acid secretion_Homo sapiens_hsa049661.17781923
28Propanoate metabolism_Homo sapiens_hsa006401.14894069
29Olfactory transduction_Homo sapiens_hsa047401.13078000
30Taste transduction_Homo sapiens_hsa047421.09492887
31Hedgehog signaling pathway_Homo sapiens_hsa043401.04876860
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01319275
33Thyroid cancer_Homo sapiens_hsa052161.00107777
34Adherens junction_Homo sapiens_hsa045200.99349190
35Parkinsons disease_Homo sapiens_hsa050120.95745552
36NF-kappa B signaling pathway_Homo sapiens_hsa040640.95045412
37Nicotine addiction_Homo sapiens_hsa050330.91664460
38TGF-beta signaling pathway_Homo sapiens_hsa043500.84235127
39Cholinergic synapse_Homo sapiens_hsa047250.82051711
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81834686
41HTLV-I infection_Homo sapiens_hsa051660.80731613
42Alcoholism_Homo sapiens_hsa050340.80298459
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80218246
44FoxO signaling pathway_Homo sapiens_hsa040680.79388926
45Caffeine metabolism_Homo sapiens_hsa002320.78902568
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70666875
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66500198
48GABAergic synapse_Homo sapiens_hsa047270.64109547
49Fanconi anemia pathway_Homo sapiens_hsa034600.63294696
50Insulin secretion_Homo sapiens_hsa049110.62794766
51Cell cycle_Homo sapiens_hsa041100.62007818
52Antigen processing and presentation_Homo sapiens_hsa046120.60166103
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59915197
54Osteoclast differentiation_Homo sapiens_hsa043800.59635936
55Systemic lupus erythematosus_Homo sapiens_hsa053220.59580562
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59336881
57Pyrimidine metabolism_Homo sapiens_hsa002400.55782136
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54201861
59Nitrogen metabolism_Homo sapiens_hsa009100.54026248
60Purine metabolism_Homo sapiens_hsa002300.53568409
61MAPK signaling pathway_Homo sapiens_hsa040100.52921892
62Long-term potentiation_Homo sapiens_hsa047200.52688438
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52621428
64Renal cell carcinoma_Homo sapiens_hsa052110.52060638
65Epstein-Barr virus infection_Homo sapiens_hsa051690.51737318
66Serotonergic synapse_Homo sapiens_hsa047260.51089555
67Hippo signaling pathway_Homo sapiens_hsa043900.50985840
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50548659
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.49263813
70Dorso-ventral axis formation_Homo sapiens_hsa043200.46838320
71Amphetamine addiction_Homo sapiens_hsa050310.46318386
72Type I diabetes mellitus_Homo sapiens_hsa049400.44656314
73Morphine addiction_Homo sapiens_hsa050320.43835635
74B cell receptor signaling pathway_Homo sapiens_hsa046620.43330739
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.42672242
76Melanogenesis_Homo sapiens_hsa049160.41495283
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.40787762
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39304547
79RNA transport_Homo sapiens_hsa030130.38904939
80cAMP signaling pathway_Homo sapiens_hsa040240.38355946
81Steroid biosynthesis_Homo sapiens_hsa001000.37287852
82Chemokine signaling pathway_Homo sapiens_hsa040620.36570479
83Alzheimers disease_Homo sapiens_hsa050100.35141068
84Endometrial cancer_Homo sapiens_hsa052130.34522587
85Prostate cancer_Homo sapiens_hsa052150.33841608
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32496712
87Viral carcinogenesis_Homo sapiens_hsa052030.32232268
88Pancreatic secretion_Homo sapiens_hsa049720.31906698
89Cocaine addiction_Homo sapiens_hsa050300.31701738
90Non-small cell lung cancer_Homo sapiens_hsa052230.30407883
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30250073
92Linoleic acid metabolism_Homo sapiens_hsa005910.29935604
93Autoimmune thyroid disease_Homo sapiens_hsa053200.29411578
94Glutamatergic synapse_Homo sapiens_hsa047240.28701980
95Allograft rejection_Homo sapiens_hsa053300.28547354
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28266561
97Ras signaling pathway_Homo sapiens_hsa040140.28210773
98Non-homologous end-joining_Homo sapiens_hsa034500.27844053
99Lysine degradation_Homo sapiens_hsa003100.27428657
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27142355

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