ADH5P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.25325336
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.25325336
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.23342053
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.66318743
5DNA deamination (GO:0045006)4.57095809
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.46274857
7response to pheromone (GO:0019236)4.32752072
8ATP synthesis coupled proton transport (GO:0015986)4.30403537
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.30403537
10chaperone-mediated protein transport (GO:0072321)4.21875448
11sequestering of actin monomers (GO:0042989)4.06396465
12dopamine transport (GO:0015872)4.02549371
13ribosomal small subunit assembly (GO:0000028)4.01874567
14response to nitrosative stress (GO:0051409)3.89563850
15protein deneddylation (GO:0000338)3.80504388
16negative regulation of telomere maintenance (GO:0032205)3.79198466
17proteasome assembly (GO:0043248)3.77236582
18electron transport chain (GO:0022900)3.74726981
19respiratory electron transport chain (GO:0022904)3.74532249
20protein neddylation (GO:0045116)3.73927415
21behavioral response to nicotine (GO:0035095)3.73583697
22aldehyde catabolic process (GO:0046185)3.72999671
23cytidine metabolic process (GO:0046087)3.64115716
24cytidine catabolic process (GO:0006216)3.64115716
25cytidine deamination (GO:0009972)3.64115716
26ubiquinone biosynthetic process (GO:0006744)3.51497745
27peptidyl-histidine modification (GO:0018202)3.51188078
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.48037150
29ubiquinone metabolic process (GO:0006743)3.47200178
30GTP biosynthetic process (GO:0006183)3.46268939
31cullin deneddylation (GO:0010388)3.45115005
32protein complex biogenesis (GO:0070271)3.45079966
33mannosylation (GO:0097502)3.35275871
34metallo-sulfur cluster assembly (GO:0031163)3.30966484
35iron-sulfur cluster assembly (GO:0016226)3.30966484
36positive regulation of uterine smooth muscle contraction (GO:0070474)3.29449443
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28936492
38pseudouridine synthesis (GO:0001522)3.18119337
39mitochondrial respiratory chain complex assembly (GO:0033108)3.16206790
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.15798588
41NADH dehydrogenase complex assembly (GO:0010257)3.15798588
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15798588
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15197892
44maturation of SSU-rRNA (GO:0030490)3.13362304
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12870470
46interferon-gamma production (GO:0032609)3.04824179
47transmission of nerve impulse (GO:0019226)3.00861991
48negative regulation of execution phase of apoptosis (GO:1900118)2.98974674
49neural tube formation (GO:0001841)2.97807070
50regulation of cellular amino acid metabolic process (GO:0006521)2.97792212
51pyrimidine ribonucleoside catabolic process (GO:0046133)2.94607314
52DNA double-strand break processing (GO:0000729)2.90950397
53dentate gyrus development (GO:0021542)2.89577212
54regulation of mitochondrial translation (GO:0070129)2.87252665
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87091084
56T cell migration (GO:0072678)2.84804519
57cellular ketone body metabolic process (GO:0046950)2.82781456
58quinone biosynthetic process (GO:1901663)2.79650100
59DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77958097
60substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.77606930
61substrate-independent telencephalic tangential migration (GO:0021826)2.77606930
62cytolysis (GO:0019835)2.77290772
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75107456
64ribosomal large subunit biogenesis (GO:0042273)2.74954009
65UTP biosynthetic process (GO:0006228)2.74915329
66regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.74346668
67regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.74346668
68platelet dense granule organization (GO:0060155)2.73548402
69protein polyglutamylation (GO:0018095)2.73356684
70positive regulation of prostaglandin secretion (GO:0032308)2.72915024
71ribosomal small subunit biogenesis (GO:0042274)2.72120016
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.70287839
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.70287839
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.70287839
75purine nucleoside triphosphate biosynthetic process (GO:0009145)2.69668277
76protein K6-linked ubiquitination (GO:0085020)2.69664320
77negative regulation of ligase activity (GO:0051352)2.69578295
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69578295
79tRNA processing (GO:0008033)2.69031458
80purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.68511492
81response to redox state (GO:0051775)2.68391286
82translational termination (GO:0006415)2.66576590
83spliceosomal snRNP assembly (GO:0000387)2.65414844
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65395612
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65089132
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65089132
87CENP-A containing nucleosome assembly (GO:0034080)2.64547784
88viral transcription (GO:0019083)2.63610975
89cotranslational protein targeting to membrane (GO:0006613)2.62834183
90termination of RNA polymerase III transcription (GO:0006386)2.62442882
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.62442882
92mitochondrial calcium ion transport (GO:0006851)2.60364040
93intracellular protein transmembrane import (GO:0044743)2.59259888
94chromatin remodeling at centromere (GO:0031055)2.58620035
95grooming behavior (GO:0007625)2.58615580
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.57874033
97protein targeting to ER (GO:0045047)2.56728978
98regulation of uterine smooth muscle contraction (GO:0070472)2.54959185
99negative T cell selection (GO:0043383)2.54838854
100phosphorylated carbohydrate dephosphorylation (GO:0046838)2.54788081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.53221355
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13539011
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.09232923
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.74752199
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.66002324
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.65940594
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08523263
8ELK1_19687146_ChIP-ChIP_HELA_Human2.62111858
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59040948
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.57913869
11ZNF274_21170338_ChIP-Seq_K562_Hela2.51556611
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.32749432
13EZH2_22144423_ChIP-Seq_EOC_Human2.17250208
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.16211280
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09777270
16VDR_23849224_ChIP-Seq_CD4+_Human2.06175535
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02471430
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00358184
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.96421838
20FOXP3_21729870_ChIP-Seq_TREG_Human1.95102665
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92161493
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91985381
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.91156477
24IGF1R_20145208_ChIP-Seq_DFB_Human1.87352462
25MYC_18940864_ChIP-ChIP_HL60_Human1.85112839
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.84657131
27VDR_22108803_ChIP-Seq_LS180_Human1.76026111
28EWS_26573619_Chip-Seq_HEK293_Human1.75102368
29GBX2_23144817_ChIP-Seq_PC3_Human1.74577148
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72766249
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69274523
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65322308
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58113049
34FUS_26573619_Chip-Seq_HEK293_Human1.52914424
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52192418
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50021955
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49829846
38P300_19829295_ChIP-Seq_ESCs_Human1.47267088
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45193180
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44613241
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41297468
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.39733538
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37185086
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36934451
45TAF15_26573619_Chip-Seq_HEK293_Human1.36809503
46NANOG_19829295_ChIP-Seq_ESCs_Human1.27381794
47SOX2_19829295_ChIP-Seq_ESCs_Human1.27381794
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27020792
49TP53_22573176_ChIP-Seq_HFKS_Human1.23964433
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23138064
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.22054726
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19058373
53AR_20517297_ChIP-Seq_VCAP_Human1.13775827
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13588671
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12809607
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.10204179
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09009932
58TTF2_22483619_ChIP-Seq_HELA_Human1.08916648
59ER_23166858_ChIP-Seq_MCF-7_Human1.08885499
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07869848
61BCAT_22108803_ChIP-Seq_LS180_Human1.07369016
62NCOR_22424771_ChIP-Seq_293T_Human1.06859765
63CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05893412
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05602155
65HTT_18923047_ChIP-ChIP_STHdh_Human1.05309111
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04967791
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04905872
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.04905872
69NANOG_20526341_ChIP-Seq_ESCs_Human1.04377264
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.04072941
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01617862
72GABP_19822575_ChIP-Seq_HepG2_Human1.01196483
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01177985
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.00917921
75PHF8_20622853_ChIP-Seq_HELA_Human0.96393946
76MYC_19829295_ChIP-Seq_ESCs_Human0.96077546
77TCF4_22108803_ChIP-Seq_LS180_Human0.95016140
78NANOG_16153702_ChIP-ChIP_HESCs_Human0.94588790
79SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93409678
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92560781
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92221056
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91790126
83RBPJ_21746931_ChIP-Seq_IB4_Human0.91212974
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91098735
85E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90662845
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.90490819
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88233410
88IRF1_19129219_ChIP-ChIP_H3396_Human0.87387936
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86989361
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.86844066
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.86108911
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85816693
93CBP_20019798_ChIP-Seq_JUKART_Human0.85471773
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85471773
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85190242
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85143331
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84756315
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.84712070
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84436220
100AR_21572438_ChIP-Seq_LNCaP_Human0.84215062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.82375149
2MP0003787_abnormal_imprinting3.50394028
3MP0002102_abnormal_ear_morphology3.41214181
4MP0008877_abnormal_DNA_methylation3.12803711
5MP0003195_calcinosis2.96380665
6MP0000372_irregular_coat_pigmentation2.91162109
7MP0005671_abnormal_response_to2.90531607
8MP0002163_abnormal_gland_morphology2.89365768
9MP0003122_maternal_imprinting2.89069417
10MP0006072_abnormal_retinal_apoptosis2.26849744
11MP0003011_delayed_dark_adaptation2.18538535
12MP0005646_abnormal_pituitary_gland1.96910922
13MP0002653_abnormal_ependyma_morphology1.93985926
14MP0005645_abnormal_hypothalamus_physiol1.87727134
15MP0009785_altered_susceptibility_to1.84987466
16MP0001293_anophthalmia1.80254564
17MP0002736_abnormal_nociception_after1.78576853
18MP0001529_abnormal_vocalization1.77859536
19MP0005551_abnormal_eye_electrophysiolog1.77252650
20MP0005379_endocrine/exocrine_gland_phen1.72974017
21MP0002938_white_spotting1.65365385
22MP0008789_abnormal_olfactory_epithelium1.62413650
23MP0000566_synostosis1.61170641
24MP0009379_abnormal_foot_pigmentation1.61163576
25MP0000631_abnormal_neuroendocrine_gland1.59449502
26MP0002876_abnormal_thyroid_physiology1.57794845
27MP0003121_genomic_imprinting1.57732145
28MP0001346_abnormal_lacrimal_gland1.53340396
29MP0003878_abnormal_ear_physiology1.53013944
30MP0005377_hearing/vestibular/ear_phenot1.53013944
31MP0003880_abnormal_central_pattern1.49746945
32MP0001986_abnormal_taste_sensitivity1.43073624
33MP0003283_abnormal_digestive_organ1.42043606
34MP0001905_abnormal_dopamine_level1.40079840
35MP0004142_abnormal_muscle_tone1.39155716
36MP0008875_abnormal_xenobiotic_pharmacok1.38043727
37MP0008058_abnormal_DNA_repair1.34830915
38MP0005253_abnormal_eye_physiology1.32895489
39MP0003123_paternal_imprinting1.32659574
40MP0001485_abnormal_pinna_reflex1.31364341
41MP0004133_heterotaxia1.30233887
42MP0003186_abnormal_redox_activity1.29613970
43MP0001501_abnormal_sleep_pattern1.29257579
44MP0000049_abnormal_middle_ear1.29054556
45MP0005075_abnormal_melanosome_morpholog1.28159330
46MP0003806_abnormal_nucleotide_metabolis1.27102164
47MP0002638_abnormal_pupillary_reflex1.27095773
48MP0003252_abnormal_bile_duct1.23037048
49MP0008995_early_reproductive_senescence1.21854674
50MP0006276_abnormal_autonomic_nervous1.20990902
51MP0001968_abnormal_touch/_nociception1.17736054
52MP0004885_abnormal_endolymph1.16543557
53MP0003136_yellow_coat_color1.15385311
54MP0002928_abnormal_bile_duct1.14119322
55MP0001984_abnormal_olfaction1.12938932
56MP0008872_abnormal_physiological_respon1.11378734
57MP0003937_abnormal_limbs/digits/tail_de1.11225530
58MP0002272_abnormal_nervous_system1.11134741
59MP0002234_abnormal_pharynx_morphology1.07977334
60MP0005084_abnormal_gallbladder_morpholo1.06924449
61MP0002160_abnormal_reproductive_system1.04630105
62MP0003786_premature_aging1.04276436
63MP0005423_abnormal_somatic_nervous1.01593117
64MP0005085_abnormal_gallbladder_physiolo1.01305785
65MP0002837_dystrophic_cardiac_calcinosis0.98684552
66MP0005389_reproductive_system_phenotype0.97788393
67MP0004043_abnormal_pH_regulation0.94729132
68MP0001963_abnormal_hearing_physiology0.93412289
69MP0000230_abnormal_systemic_arterial0.88016690
70MP0000639_abnormal_adrenal_gland0.86688569
71MP0002095_abnormal_skin_pigmentation0.84869037
72MP0006036_abnormal_mitochondrial_physio0.84792731
73MP0005332_abnormal_amino_acid0.84093327
74MP0005499_abnormal_olfactory_system0.82630592
75MP0005394_taste/olfaction_phenotype0.82630592
76MP0000026_abnormal_inner_ear0.82482131
77MP0009745_abnormal_behavioral_response0.81549770
78MP0003938_abnormal_ear_development0.78426733
79MP0002233_abnormal_nose_morphology0.77990046
80MP0002751_abnormal_autonomic_nervous0.76804695
81MP0005636_abnormal_mineral_homeostasis0.75129058
82MP0001119_abnormal_female_reproductive0.73761815
83MP0002210_abnormal_sex_determination0.73676841
84MP0001542_abnormal_bone_strength0.73669980
85MP0003137_abnormal_impulse_conducting0.72936252
86MP0001486_abnormal_startle_reflex0.72108893
87MP0004742_abnormal_vestibular_system0.71779997
88MP0001286_abnormal_eye_development0.71123275
89MP0002006_tumorigenesis0.69441907
90MP0003866_abnormal_defecation0.68679884
91MP0006035_abnormal_mitochondrial_morpho0.67557457
92MP0004147_increased_porphyrin_level0.67442419
93MP0005195_abnormal_posterior_eye0.66516740
94MP0004019_abnormal_vitamin_homeostasis0.65628765
95MP0002090_abnormal_vision0.62704866
96MP0000685_abnormal_immune_system0.62700901
97MP0001929_abnormal_gametogenesis0.62431199
98MP0002752_abnormal_somatic_nervous0.61052353
99MP0010386_abnormal_urinary_bladder0.61009895
100MP0000653_abnormal_sex_gland0.60514099

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.34872014
2Acute encephalopathy (HP:0006846)4.01209253
3Aplastic anemia (HP:0001915)3.96436496
4Mitochondrial inheritance (HP:0001427)3.84436163
5Abnormal mitochondria in muscle tissue (HP:0008316)3.82403645
6Renal Fanconi syndrome (HP:0001994)3.67317826
7Increased CSF lactate (HP:0002490)3.62818964
8Progressive macrocephaly (HP:0004481)3.57608022
9Reticulocytopenia (HP:0001896)3.25810187
10Increased hepatocellular lipid droplets (HP:0006565)3.22489036
11Abnormality of the labia minora (HP:0012880)3.11772869
12Hepatic necrosis (HP:0002605)3.07977959
13Congenital stationary night blindness (HP:0007642)3.05024909
14Hepatocellular necrosis (HP:0001404)3.00683849
15IgG deficiency (HP:0004315)2.99891642
16Pancytopenia (HP:0001876)2.99272652
17Hypoproteinemia (HP:0003075)2.97704688
18Stenosis of the external auditory canal (HP:0000402)2.85277224
19Lipid accumulation in hepatocytes (HP:0006561)2.82100213
20Abnormality of cells of the erythroid lineage (HP:0012130)2.80261385
21Neonatal respiratory distress (HP:0002643)2.79206735
22Abnormal number of erythroid precursors (HP:0012131)2.78334838
23Macrocytic anemia (HP:0001972)2.75457599
24Elevated erythrocyte sedimentation rate (HP:0003565)2.67678573
25Pancreatic cysts (HP:0001737)2.62273452
26Medial flaring of the eyebrow (HP:0010747)2.57965194
27Type II lissencephaly (HP:0007260)2.56110859
28Methylmalonic acidemia (HP:0002912)2.52946480
29Increased intramyocellular lipid droplets (HP:0012240)2.49869626
30True hermaphroditism (HP:0010459)2.49833890
31Severe combined immunodeficiency (HP:0004430)2.48562712
32Adrenal hypoplasia (HP:0000835)2.44100513
33Polydipsia (HP:0001959)2.42456762
34Abnormal drinking behavior (HP:0030082)2.42456762
35Cerebral edema (HP:0002181)2.42422594
36Renal cortical cysts (HP:0000803)2.41375459
37Absent thumb (HP:0009777)2.41237823
38Retinal dysplasia (HP:0007973)2.40313127
39Abnormal rod and cone electroretinograms (HP:0008323)2.40102130
40Molar tooth sign on MRI (HP:0002419)2.37046854
41Abnormality of midbrain morphology (HP:0002418)2.37046854
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36356215
43Pancreatic fibrosis (HP:0100732)2.36128233
44Generalized aminoaciduria (HP:0002909)2.33891649
45Concave nail (HP:0001598)2.31214103
46Increased serum lactate (HP:0002151)2.29687237
47Optic disc pallor (HP:0000543)2.26006185
48Lactic acidosis (HP:0003128)2.25557721
49Congenital primary aphakia (HP:0007707)2.24137790
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23428891
51Sclerocornea (HP:0000647)2.22584790
52IgM deficiency (HP:0002850)2.19328065
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16942220
54Abnormality of renal resorption (HP:0011038)2.15591055
55Keratoconus (HP:0000563)2.15075323
56Increased corneal curvature (HP:0100692)2.15075323
57Gait imbalance (HP:0002141)2.14096490
58Vaginal atresia (HP:0000148)2.12555053
59Abnormality of the costochondral junction (HP:0000919)2.12282104
60Nephrogenic diabetes insipidus (HP:0009806)2.08948606
61Abnormality of urine glucose concentration (HP:0011016)2.08551343
62Glycosuria (HP:0003076)2.08551343
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.08478012
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08037968
65Asplenia (HP:0001746)2.07642008
66Genital tract atresia (HP:0001827)2.05896326
67Oral leukoplakia (HP:0002745)2.05696399
68Exertional dyspnea (HP:0002875)2.03992868
69Abnormality of the renal cortex (HP:0011035)2.03462123
70Lethargy (HP:0001254)2.03399798
71Metaphyseal dysplasia (HP:0100255)1.99078142
72Hyperglycinemia (HP:0002154)1.98139178
73Congenital, generalized hypertrichosis (HP:0004540)1.97452471
74Hypomagnesemia (HP:0002917)1.95779066
75Aplasia/Hypoplasia of the spleen (HP:0010451)1.93282881
76Thyroiditis (HP:0100646)1.93060220
77Stomatitis (HP:0010280)1.90017239
78Polyuria (HP:0000103)1.86922599
79Septo-optic dysplasia (HP:0100842)1.85977252
80Constricted visual fields (HP:0001133)1.85610147
81Increased muscle lipid content (HP:0009058)1.85301192
82Abnormality of DNA repair (HP:0003254)1.85162658
83Leukodystrophy (HP:0002415)1.83271236
84Attenuation of retinal blood vessels (HP:0007843)1.82751454
85Colon cancer (HP:0003003)1.81356457
86Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79690825
87Methylmalonic aciduria (HP:0012120)1.76918649
88Respiratory failure (HP:0002878)1.76734305
89Combined immunodeficiency (HP:0005387)1.74483995
90Abolished electroretinogram (ERG) (HP:0000550)1.72314403
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72248073
92Depressed nasal tip (HP:0000437)1.71301346
93T lymphocytopenia (HP:0005403)1.71058207
94Decreased central vision (HP:0007663)1.70874133
95Optic nerve hypoplasia (HP:0000609)1.70806024
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70560027
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.69089376
98Exercise intolerance (HP:0003546)1.68674100
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68629904
100Abnormality of serum amino acid levels (HP:0003112)1.67848172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.70543062
2TESK13.58205332
3ZAK3.48683294
4VRK22.92186592
5KDR2.78103060
6NUAK12.59595157
7TXK2.54646905
8ADRBK22.51251758
9FRK2.46993022
10LIMK12.23098573
11NME12.18018583
12PASK2.01164061
13MAPKAPK31.87351301
14TESK21.86161445
15TRIM281.82187479
16FGFR21.77412616
17MAP4K21.68917419
18BMPR1B1.66080124
19VRK11.64544379
20WNK41.60391212
21WNK31.49952091
22ITK1.45696476
23BUB11.43763091
24MST41.42113664
25TEC1.39186138
26PINK11.39032533
27SRPK11.37697942
28TLK11.29264802
29BCKDK1.26251568
30CSNK1G11.21804722
31CSNK1G31.21106571
32PLK31.19808641
33CDK31.18318337
34OXSR11.18155308
35TAOK31.10755555
36GRK11.09390252
37STK391.09242768
38SCYL21.05943199
39MAP4K11.01158820
40BCR1.00035191
41GRK60.97008324
42INSRR0.96534115
43PLK40.95316731
44PLK20.90716910
45MKNK20.87914053
46PRKCQ0.85414684
47TAF10.84823451
48NEK10.84163871
49DYRK20.83373319
50MAPK130.82576667
51CSNK1G20.82537091
52CHEK20.79238380
53TNIK0.76286108
54MKNK10.74372631
55SYK0.73247189
56TNK20.73036209
57ERBB30.72428204
58PLK10.71235960
59MYLK0.71228011
60CDC70.70219465
61MAP3K120.64180870
62ADRBK10.61722820
63TSSK60.60585775
64CSNK1A1L0.60350974
65STK38L0.57000658
66BRSK20.56915661
67RPS6KA40.56870395
68CAMKK20.55699088
69EPHA40.52230072
70RPS6KA50.51558014
71IKBKE0.49988962
72CAMK10.49727965
73LCK0.49618178
74PBK0.49555721
75STK110.48787348
76PRKCG0.48739891
77BRSK10.48665880
78CSNK2A10.47290480
79PIM10.47086373
80ACVR1B0.45267864
81PRKACA0.45049640
82CSNK2A20.42244333
83MINK10.41955896
84AURKB0.41342008
85TIE10.41032218
86PRKCA0.40934792
87BTK0.40807326
88CSNK1A10.40721570
89EIF2AK30.40717485
90OBSCN0.40616681
91ROCK10.40599283
92CDK80.39251833
93GRK70.38471259
94PIK3CG0.38145969
95TGFBR10.37809140
96PAK30.37373149
97DAPK10.36479979
98INSR0.34571682
99EIF2AK20.34354784
100DYRK30.33279186

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.00669230
2Oxidative phosphorylation_Homo sapiens_hsa001903.50898801
3Primary immunodeficiency_Homo sapiens_hsa053403.23892038
4Ribosome_Homo sapiens_hsa030103.18399384
5Parkinsons disease_Homo sapiens_hsa050123.11896446
6Protein export_Homo sapiens_hsa030602.82707836
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55199782
8RNA polymerase_Homo sapiens_hsa030202.46694778
9Huntingtons disease_Homo sapiens_hsa050162.07523921
10Alzheimers disease_Homo sapiens_hsa050101.97781682
11Selenocompound metabolism_Homo sapiens_hsa004501.74781140
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74495230
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72946942
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69577705
15Homologous recombination_Homo sapiens_hsa034401.66180377
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65305524
17Propanoate metabolism_Homo sapiens_hsa006401.64193588
18Fanconi anemia pathway_Homo sapiens_hsa034601.60793373
19One carbon pool by folate_Homo sapiens_hsa006701.58040438
20Cardiac muscle contraction_Homo sapiens_hsa042601.55470511
21Butanoate metabolism_Homo sapiens_hsa006501.52834735
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51852251
23Fatty acid elongation_Homo sapiens_hsa000621.45146967
24Mismatch repair_Homo sapiens_hsa034301.37048621
25Steroid biosynthesis_Homo sapiens_hsa001001.36812037
26Basal transcription factors_Homo sapiens_hsa030221.34776828
27Spliceosome_Homo sapiens_hsa030401.31764300
28Tryptophan metabolism_Homo sapiens_hsa003801.31326320
29Pyrimidine metabolism_Homo sapiens_hsa002401.25801632
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.25721220
31RNA degradation_Homo sapiens_hsa030181.23211498
32Nitrogen metabolism_Homo sapiens_hsa009101.22844185
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22174605
34Linoleic acid metabolism_Homo sapiens_hsa005911.21497679
35Folate biosynthesis_Homo sapiens_hsa007901.20617900
36DNA replication_Homo sapiens_hsa030301.18315149
37Phototransduction_Homo sapiens_hsa047441.17712614
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17195447
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15197945
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12184579
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10662912
42Peroxisome_Homo sapiens_hsa041461.07591174
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07456148
44Base excision repair_Homo sapiens_hsa034101.03953103
45Fatty acid degradation_Homo sapiens_hsa000711.03928175
46Purine metabolism_Homo sapiens_hsa002301.03548033
47Regulation of autophagy_Homo sapiens_hsa041401.03118614
48Nucleotide excision repair_Homo sapiens_hsa034200.98535568
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96871930
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95209153
51Antigen processing and presentation_Homo sapiens_hsa046120.90811265
52beta-Alanine metabolism_Homo sapiens_hsa004100.90004051
53Retinol metabolism_Homo sapiens_hsa008300.87681144
54Sulfur metabolism_Homo sapiens_hsa009200.86498150
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86187520
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86124828
57Chemical carcinogenesis_Homo sapiens_hsa052040.84457091
58Tyrosine metabolism_Homo sapiens_hsa003500.82726489
59Type I diabetes mellitus_Homo sapiens_hsa049400.80701326
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.79199031
61RNA transport_Homo sapiens_hsa030130.78130787
62Histidine metabolism_Homo sapiens_hsa003400.73903708
63Nicotine addiction_Homo sapiens_hsa050330.73656751
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71766193
65Metabolic pathways_Homo sapiens_hsa011000.70361803
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.70222689
67Ether lipid metabolism_Homo sapiens_hsa005650.69527050
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.68346176
69Fatty acid metabolism_Homo sapiens_hsa012120.68013797
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62491269
71Glutathione metabolism_Homo sapiens_hsa004800.61950941
72Arachidonic acid metabolism_Homo sapiens_hsa005900.61862025
73Pyruvate metabolism_Homo sapiens_hsa006200.60895740
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59782212
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59029216
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58851229
77Hedgehog signaling pathway_Homo sapiens_hsa043400.56616975
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55785934
79Olfactory transduction_Homo sapiens_hsa047400.54733938
80Hematopoietic cell lineage_Homo sapiens_hsa046400.49592901
81Fat digestion and absorption_Homo sapiens_hsa049750.49396914
82Allograft rejection_Homo sapiens_hsa053300.47179774
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45701883
84Graft-versus-host disease_Homo sapiens_hsa053320.44744262
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.44061415
86Caffeine metabolism_Homo sapiens_hsa002320.43575744
87T cell receptor signaling pathway_Homo sapiens_hsa046600.41357625
88Autoimmune thyroid disease_Homo sapiens_hsa053200.40246926
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40203190
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.38524379
91Taste transduction_Homo sapiens_hsa047420.36809846
92Serotonergic synapse_Homo sapiens_hsa047260.34901573
93Arginine and proline metabolism_Homo sapiens_hsa003300.34659670
94N-Glycan biosynthesis_Homo sapiens_hsa005100.31136056
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31109652
96Morphine addiction_Homo sapiens_hsa050320.30445876
97p53 signaling pathway_Homo sapiens_hsa041150.29058476
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28465168
99Collecting duct acid secretion_Homo sapiens_hsa049660.22050677
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20083291

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