ADH7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diterpenoid biosynthetic process (GO:0016102)9.78923034
2axoneme assembly (GO:0035082)9.56766123
3left/right pattern formation (GO:0060972)8.42941568
4negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)7.48217053
5vitamin transmembrane transport (GO:0035461)7.44808094
6terpenoid biosynthetic process (GO:0016114)7.01162937
7one-carbon compound transport (GO:0019755)6.48302304
8regulation of cilium movement (GO:0003352)6.45307932
9pyrimidine-containing compound transmembrane transport (GO:0072531)6.40218479
10microtubule bundle formation (GO:0001578)5.91506045
11intraciliary transport (GO:0042073)5.71016085
12left/right axis specification (GO:0070986)5.65689291
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.53826836
14L-phenylalanine catabolic process (GO:0006559)5.53826836
15sulfur amino acid catabolic process (GO:0000098)5.51549933
16lung epithelium development (GO:0060428)5.49984846
17ventricular system development (GO:0021591)5.39517342
18tolerance induction (GO:0002507)5.36430243
19cilium organization (GO:0044782)5.31112884
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.22869393
21L-phenylalanine metabolic process (GO:0006558)5.22869393
22cilium assembly (GO:0042384)5.16664088
23aromatic amino acid family catabolic process (GO:0009074)5.04807747
24peptidyl-glutamic acid carboxylation (GO:0017187)4.99728481
25protein carboxylation (GO:0018214)4.99728481
26negative regulation of T cell differentiation in thymus (GO:0033085)4.98603581
27negative regulation of protein activation cascade (GO:2000258)4.95454653
28* retinoic acid metabolic process (GO:0042573)4.81541830
29centriole assembly (GO:0098534)4.80953666
30* ethanol oxidation (GO:0006069)4.80403358
31establishment of apical/basal cell polarity (GO:0035089)4.76459607
32bile acid biosynthetic process (GO:0006699)4.76277339
33negative regulation of complement activation (GO:0045916)4.73038219
34glomerular epithelial cell development (GO:0072310)4.71306934
35tryptophan catabolic process (GO:0006569)4.71045098
36indole-containing compound catabolic process (GO:0042436)4.71045098
37indolalkylamine catabolic process (GO:0046218)4.71045098
38kynurenine metabolic process (GO:0070189)4.68120065
39regulation of protein activation cascade (GO:2000257)4.67751377
40protein localization to cilium (GO:0061512)4.60779984
41regulation of germinal center formation (GO:0002634)4.60578111
42high-density lipoprotein particle remodeling (GO:0034375)4.60436688
43progesterone metabolic process (GO:0042448)4.58477855
44negative regulation of B cell mediated immunity (GO:0002713)4.58134260
45negative regulation of immunoglobulin mediated immune response (GO:0002890)4.58134260
46response to xenobiotic stimulus (GO:0009410)4.52285932
47regulation of complement activation (GO:0030449)4.49313479
48triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.47602145
49renal absorption (GO:0070293)4.41336222
50establishment of tissue polarity (GO:0007164)4.39497758
51establishment of planar polarity (GO:0001736)4.39497758
52xenobiotic catabolic process (GO:0042178)4.37288971
53cysteine metabolic process (GO:0006534)4.37191022
54sperm capacitation (GO:0048240)4.37132601
55tryptophan metabolic process (GO:0006568)4.37102036
56positive regulation of tolerance induction (GO:0002645)4.36773583
57O-glycan processing (GO:0016266)4.35465728
58L-ascorbic acid metabolic process (GO:0019852)4.34696994
59alpha-linolenic acid metabolic process (GO:0036109)4.32450519
60negative regulation of fibrinolysis (GO:0051918)4.30366429
61amino-acid betaine metabolic process (GO:0006577)4.29476197
62polyketide metabolic process (GO:0030638)4.27517914
63doxorubicin metabolic process (GO:0044598)4.27517914
64daunorubicin metabolic process (GO:0044597)4.27517914
65glyoxylate metabolic process (GO:0046487)4.24692923
66hydrogen peroxide biosynthetic process (GO:0050665)4.21194210
67establishment or maintenance of monopolar cell polarity (GO:0061339)4.18383865
68establishment of monopolar cell polarity (GO:0061162)4.18383865
69regulation of fibrinolysis (GO:0051917)4.15926818
70cellular component assembly involved in morphogenesis (GO:0010927)4.12127925
71cellular glucuronidation (GO:0052695)4.06328582
72fibrinolysis (GO:0042730)4.04079021
73glucuronate metabolic process (GO:0019585)4.03807625
74uronic acid metabolic process (GO:0006063)4.03807625
75valine metabolic process (GO:0006573)4.01200301
76complement activation, alternative pathway (GO:0006957)3.99185446
77fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.97820072
78multicellular organismal water homeostasis (GO:0050891)3.96650333
79microtubule-based movement (GO:0007018)3.96023675
80reverse cholesterol transport (GO:0043691)3.94074096
81regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.88878297
82desmosome organization (GO:0002934)3.88633915
83urea metabolic process (GO:0019627)3.88155617
84urea cycle (GO:0000050)3.88155617
85aldehyde catabolic process (GO:0046185)3.87459881
86bile acid metabolic process (GO:0008206)3.87065686
87lateral sprouting from an epithelium (GO:0060601)3.86855164
88* ethanol metabolic process (GO:0006067)3.85579364
89cell projection assembly (GO:0030031)3.83794738
90cilium morphogenesis (GO:0060271)3.79717520
91aminoglycoside antibiotic metabolic process (GO:0030647)3.79050292
92negative regulation of lipase activity (GO:0060192)3.78350503
93reactive oxygen species biosynthetic process (GO:1903409)3.78327942
94linoleic acid metabolic process (GO:0043651)3.75762453
95retinal metabolic process (GO:0042574)3.74836646
96carnitine metabolic process (GO:0009437)3.72833137
97regulation of microtubule-based movement (GO:0060632)3.72740263
98water homeostasis (GO:0030104)3.71156353
99epoxygenase P450 pathway (GO:0019373)3.70890460
100phospholipid efflux (GO:0033700)3.70226922
101macromolecular complex remodeling (GO:0034367)3.66831301
102plasma lipoprotein particle remodeling (GO:0034369)3.66831301
103protein-lipid complex remodeling (GO:0034368)3.66831301
104glutathione derivative metabolic process (GO:1901685)3.63969481
105glutathione derivative biosynthetic process (GO:1901687)3.63969481
106acute-phase response (GO:0006953)3.61493580
107* primary alcohol metabolic process (GO:0034308)3.60035170
108serine family amino acid catabolic process (GO:0009071)3.59757098
109extracellular fibril organization (GO:0043206)3.58802733
110response to nitrosative stress (GO:0051409)3.58139602
111phospholipid homeostasis (GO:0055091)3.57067970
112alpha-amino acid catabolic process (GO:1901606)3.54921398
113aromatic amino acid family metabolic process (GO:0009072)3.54572204
114benzene-containing compound metabolic process (GO:0042537)3.54507521
115cellular aldehyde metabolic process (GO:0006081)3.53591772
116regulation of cholesterol biosynthetic process (GO:0045540)3.51662878
117oligosaccharide biosynthetic process (GO:0009312)3.51382566
118regulation of cholesterol esterification (GO:0010872)3.51371327
119regulation of triglyceride catabolic process (GO:0010896)3.50684154
120regulation of female gonad development (GO:2000194)3.49863134
121tyrosine metabolic process (GO:0006570)3.49294821
122coenzyme catabolic process (GO:0009109)3.48944601
123* primary alcohol catabolic process (GO:0034310)3.48872103
124nitrogen cycle metabolic process (GO:0071941)3.47350693
125homocysteine metabolic process (GO:0050667)3.45893238
126cytoplasmic microtubule organization (GO:0031122)3.45489725
127negative regulation of humoral immune response (GO:0002921)3.44609825
128negative regulation of sterol transport (GO:0032372)3.43893301
129negative regulation of cholesterol transport (GO:0032375)3.43893301
130regulation of cholesterol homeostasis (GO:2000188)3.41656292
131ear development (GO:0043583)3.41619885
132exogenous drug catabolic process (GO:0042738)3.40550495
133triglyceride homeostasis (GO:0070328)3.38409073
134acylglycerol homeostasis (GO:0055090)3.38409073
135regulation of phospholipase A2 activity (GO:0032429)3.38251415
136regulation of bile acid biosynthetic process (GO:0070857)3.37535877
137cellular amino acid catabolic process (GO:0009063)3.36618079
138antibacterial humoral response (GO:0019731)3.34297265
139regulation of interleukin-5 production (GO:0032674)3.34201325
140nucleoside diphosphate phosphorylation (GO:0006165)3.34037194
141imidazole-containing compound metabolic process (GO:0052803)3.33340087
142regulation of tolerance induction (GO:0002643)3.32841257
143amine catabolic process (GO:0009310)3.29543108
144cellular biogenic amine catabolic process (GO:0042402)3.29543108
145positive regulation of blood coagulation (GO:0030194)3.29289520
146positive regulation of hemostasis (GO:1900048)3.29289520
147positive regulation of coagulation (GO:0050820)3.28258936
148acute inflammatory response (GO:0002526)3.25512764
149* retinol metabolic process (GO:0042572)3.24168322
150bile acid and bile salt transport (GO:0015721)3.24159400
151lysine catabolic process (GO:0006554)3.22433796
152lysine metabolic process (GO:0006553)3.22433796
153excretion (GO:0007588)3.21545472
154regulation of cholesterol metabolic process (GO:0090181)3.19315419
155fibril organization (GO:0097435)3.19117600
156flavonoid metabolic process (GO:0009812)3.18758627
157cholesterol efflux (GO:0033344)3.18111557
158glycine metabolic process (GO:0006544)3.17290703
159antimicrobial humoral response (GO:0019730)3.15809442
160complement activation, classical pathway (GO:0006958)3.15615046
161complement activation (GO:0006956)3.15590463
162microtubule depolymerization (GO:0007019)3.10909456
163apical protein localization (GO:0045176)3.09264869
164protein O-linked glycosylation (GO:0006493)3.05048955
165positive regulation of smoothened signaling pathway (GO:0045880)3.04303630
166glutathione metabolic process (GO:0006749)3.01874373
167C21-steroid hormone metabolic process (GO:0008207)2.99061727
168regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.96596547
169polyol transport (GO:0015791)2.96456455
170microtubule polymerization or depolymerization (GO:0031109)2.95579551
171phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.92963339
172hydrogen peroxide catabolic process (GO:0042744)2.87442808
173negative regulation of inclusion body assembly (GO:0090084)2.86182394
174regulation of interleukin-13 production (GO:0032656)2.85869807
175hydrogen peroxide metabolic process (GO:0042743)2.84340889
176calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.83063544
177glutathione biosynthetic process (GO:0006750)2.80614110
178innate immune response in mucosa (GO:0002227)2.71573817
179hypotonic response (GO:0006971)2.69243137
180sodium ion homeostasis (GO:0055078)2.67057044
181drug catabolic process (GO:0042737)2.65874308
182centriole replication (GO:0007099)2.63564247
183sialylation (GO:0097503)2.61346749
184axonemal dynein complex assembly (GO:0070286)19.6415218
185cilium or flagellum-dependent cell motility (GO:0001539)15.5565966
186cilium movement (GO:0003341)13.8638082
187motile cilium assembly (GO:0044458)13.5278368
188epithelial cilium movement (GO:0003351)12.4610904
189epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.3569319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.79332141
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.21582481
3TP63_17297297_ChIP-ChIP_HaCaT_Human6.16956835
4* RXR_22158963_ChIP-Seq_LIVER_Mouse5.60189137
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.11482150
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.90730122
7* LXR_22158963_ChIP-Seq_LIVER_Mouse4.51778898
8EGR1_23403033_ChIP-Seq_LIVER_Mouse4.45732286
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.42682408
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.20733141
11RARG_19884340_ChIP-ChIP_MEFs_Mouse3.18015156
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.99287318
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.88212661
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.87413997
15DROSHA_22980978_ChIP-Seq_HELA_Human2.84135111
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.74080806
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34555207
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.23886148
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.23691152
20CLOCK_20551151_ChIP-Seq_293T_Human2.14247452
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05999222
22* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.97618915
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96489395
24* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77162578
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74756436
26SOX9_24532713_ChIP-Seq_HFSC_Mouse1.72104833
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69516535
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68814675
29ZNF263_19887448_ChIP-Seq_K562_Human1.68292201
30STAT1_20625510_ChIP-Seq_HELA_Human1.67629506
31VDR_22108803_ChIP-Seq_LS180_Human1.66232107
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.65177424
33SMC4_20622854_ChIP-Seq_HELA_Human1.62950528
34* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.62690915
35GATA1_22025678_ChIP-Seq_K562_Human1.60954044
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54876121
37* TP63_22573176_ChIP-Seq_HFKS_Human1.54242722
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54131457
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54131457
40* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53187667
41* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53187667
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48079327
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47294819
44SOX2_20726797_ChIP-Seq_SW620_Human1.47205347
45GATA4_25053715_ChIP-Seq_YYC3_Human1.42989730
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.41495404
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40241836
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39985533
49P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35563516
50SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33286770
51TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33204580
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32062560
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31842798
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31771126
55* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30220272
56ETV1_20927104_ChIP-Seq_GIST48_Human1.30209250
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.29116280
58FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27705273
59GATA1_19941826_ChIP-Seq_K562_Human1.27563063
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.26712145
61* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.25447196
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25143000
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23672879
64TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23396218
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21618456
66FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20177091
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19325899
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18778372
69CJUN_26792858_Chip-Seq_BT549_Human1.17906665
70PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17750498
71CTCF_27219007_Chip-Seq_Bcells_Human1.14045512
72PHF8_20622853_ChIP-Seq_HELA_Human1.13517275
73HNFA_21074721_ChIP-Seq_CACO-2_Human1.13177467
74CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13172435
75SMRT_27268052_Chip-Seq_Bcells_Human1.11330118
76TP53_18474530_ChIP-ChIP_U2OS_Human1.11282184
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10326235
78CTCF_20526341_ChIP-Seq_ESCs_Human1.08196041
79AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07143590
80RBPJ_21746931_ChIP-Seq_IB4_Human1.06548429
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05692156
82GATA6_21074721_ChIP-Seq_CACO-2_Human1.05603465
83GATA6_25053715_ChIP-Seq_YYC3_Human1.05411767
84CREB1_26743006_Chip-Seq_LNCaP_Human1.04643523
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04314247
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03860280
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03560312
88CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03551795
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.03027442
90* CEBPB_22108803_ChIP-Seq_LS180_Human1.02888757
91AHR_22903824_ChIP-Seq_MCF-7_Human1.02624675
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01311647
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00614543
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00207535
95P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.98757308
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.98147933
97P68_20966046_ChIP-Seq_HELA_Human0.97897666
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97894889
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97270746
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.96933916
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96100155
102TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96057461
103ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95061976
104RXR_22108803_ChIP-Seq_LS180_Human0.94130178
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94058630
106CDX2_20551321_ChIP-Seq_CACO-2_Human0.93977037
107TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93339736
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92702282
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92557991
110RUNX1_27514584_Chip-Seq_MCF-7_Human0.92391773
111PHF8_20622854_ChIP-Seq_HELA_Human0.92297970
112* TP63_23658742_ChIP-Seq_EP156T_Human0.92183900
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91529718
114NFYA_21822215_ChIP-Seq_K562_Human0.91422990
115ATF3_27146783_Chip-Seq_COLON_Human0.91142874
116RACK7_27058665_Chip-Seq_MCF-7_Human0.90717912
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90712100
118HNF4A_19822575_ChIP-Seq_HepG2_Human0.90068120
119EZH2_27294783_Chip-Seq_ESCs_Mouse0.89664468
120CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88622901
121GATA3_24758297_ChIP-Seq_MCF-7_Human0.88614784
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87280946
123EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85493933
124GATA2_19941826_ChIP-Seq_K562_Human0.84982110
125NFYB_21822215_ChIP-Seq_K562_Human0.84405689
126AR_20517297_ChIP-Seq_VCAP_Human0.83484648
127TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.83338334
128TP53_16413492_ChIP-PET_HCT116_Human0.83234339
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.83098120
130E2F1_20622854_ChIP-Seq_HELA_Human0.82781007
131FLI1_21867929_ChIP-Seq_CD8_Mouse0.82260279
132P300_27268052_Chip-Seq_Bcells_Human0.82117018
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81315365
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79300292
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.76269135
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.74823631
137FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74694304
138* FOXA1_25552417_ChIP-Seq_VCAP_Human0.74479873
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73733246
140TBX20_22080862_ChIP-Seq_HEART_Mouse0.73349327
141TBX20_22328084_ChIP-Seq_HEART_Mouse0.73349327
142* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71116636
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.71020657
144KLF5_25053715_ChIP-Seq_YYC3_Human0.70664865
145EGR1_19032775_ChIP-ChIP_M12_Human0.70303766
146IRF8_22096565_ChIP-ChIP_GC-B_Human0.67849922
147ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67278429
148AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66501645
149JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65781664
150BCAT_22108803_ChIP-Seq_LS180_Human0.64081070
151FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.62867825
152STAT6_21828071_ChIP-Seq_BEAS2B_Human0.62430345
153SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.62415070
154UBF1/2_26484160_Chip-Seq_HMECs_Human0.61687963
155RBPJ_22232070_ChIP-Seq_NCS_Mouse0.60475216
156LXR_22292898_ChIP-Seq_THP-1_Human0.60288060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.41346221
2MP0002653_abnormal_ependyma_morphology5.88197623
3MP0005360_urolithiasis4.84228469
4MP0005085_abnormal_gallbladder_physiolo4.75510396
5MP0005365_abnormal_bile_salt4.40204119
6* MP0008875_abnormal_xenobiotic_pharmacok4.16063536
7MP0009780_abnormal_chondrocyte_physiolo4.13995664
8MP0008789_abnormal_olfactory_epithelium3.67868716
9MP0001984_abnormal_olfaction3.42564527
10MP0003252_abnormal_bile_duct3.22047132
11MP0003806_abnormal_nucleotide_metabolis3.22009007
12MP0004133_heterotaxia3.12301015
13MP0000566_synostosis3.00956783
14MP0002277_abnormal_respiratory_mucosa2.92069781
15MP0002796_impaired_skin_barrier2.88421643
16MP0005083_abnormal_biliary_tract2.84344391
17MP0010329_abnormal_lipoprotein_level2.67108860
18MP0002254_reproductive_system_inflammat2.58708811
19MP0005499_abnormal_olfactory_system2.41327964
20MP0005394_taste/olfaction_phenotype2.41327964
21MP0003705_abnormal_hypodermis_morpholog2.39484179
22MP0003878_abnormal_ear_physiology2.23987140
23MP0005377_hearing/vestibular/ear_phenot2.23987140
24MP0005623_abnormal_meninges_morphology2.22255670
25MP0005275_abnormal_skin_tensile2.18676990
26MP0000678_abnormal_parathyroid_gland2.15401989
27MP0001666_abnormal_nutrient_absorption2.15190580
28MP0002060_abnormal_skin_morphology2.09306224
29* MP0004019_abnormal_vitamin_homeostasis2.02640942
30MP0002168_other_aberrant_phenotype1.99839226
31MP0009379_abnormal_foot_pigmentation1.91201516
32MP0001765_abnormal_ion_homeostasis1.90323175
33MP0000465_gastrointestinal_hemorrhage1.78446234
34MP0001346_abnormal_lacrimal_gland1.77333585
35MP0003186_abnormal_redox_activity1.77292532
36MP0003195_calcinosis1.76305248
37MP0010155_abnormal_intestine_physiology1.72166671
38MP0010368_abnormal_lymphatic_system1.68192853
39MP0010234_abnormal_vibrissa_follicle1.67431755
40MP0009840_abnormal_foam_cell1.66983362
41MP0005501_abnormal_skin_physiology1.66228282
42MP0000579_abnormal_nail_morphology1.65609689
43MP0010030_abnormal_orbit_morphology1.65271363
44MP0005332_abnormal_amino_acid1.61793462
45MP0002118_abnormal_lipid_homeostasis1.53424017
46MP0008004_abnormal_stomach_pH1.51978941
47MP0003191_abnormal_cellular_cholesterol1.51312024
48MP0000609_abnormal_liver_physiology1.51094758
49MP0002160_abnormal_reproductive_system1.50542900
50MP0005408_hypopigmentation1.45966864
51MP0003941_abnormal_skin_development1.44789525
52MP0002909_abnormal_adrenal_gland1.42958997
53MP0003011_delayed_dark_adaptation1.41607531
54MP0008438_abnormal_cutaneous_collagen1.41029326
55MP0003453_abnormal_keratinocyte_physiol1.39479554
56MP0005248_abnormal_Harderian_gland1.39217269
57MP0000647_abnormal_sebaceous_gland1.39123933
58MP0002132_abnormal_respiratory_system1.38117298
59MP0002138_abnormal_hepatobiliary_system1.38002714
60MP0003566_abnormal_cell_adhesion1.37410358
61MP0000467_abnormal_esophagus_morphology1.31199026
62MP0001216_abnormal_epidermal_layer1.31084424
63MP0002098_abnormal_vibrissa_morphology1.26853781
64MP0009053_abnormal_anal_canal1.26823122
65MP0005319_abnormal_enzyme/_coenzyme1.26550018
66MP0004264_abnormal_extraembryonic_tissu1.25859207
67MP0005395_other_phenotype1.25096818
68MP0002876_abnormal_thyroid_physiology1.23995551
69MP0010771_integument_phenotype1.19937390
70MP0000383_abnormal_hair_follicle1.19702039
71MP0000858_altered_metastatic_potential1.19618262
72MP0004381_abnormal_hair_follicle1.19340722
73MP0000681_abnormal_thyroid_gland1.16474632
74MP0002233_abnormal_nose_morphology1.13709688
75MP0003303_peritoneal_inflammation1.13072163
76MP0000537_abnormal_urethra_morphology1.11903706
77MP0004043_abnormal_pH_regulation1.11065404
78MP0010678_abnormal_skin_adnexa1.11045977
79MP0002877_abnormal_melanocyte_morpholog1.10860715
80MP0009643_abnormal_urine_homeostasis1.09681026
81MP0001243_abnormal_dermal_layer1.08610177
82MP0003950_abnormal_plasma_membrane1.08469408
83MP0009764_decreased_sensitivity_to1.07846338
84MP0006054_spinal_hemorrhage1.07199958
85MP0005451_abnormal_body_composition1.06580738
86MP0005023_abnormal_wound_healing1.05032678
87MP0004883_abnormal_blood_vessel1.00346110
88MP0000762_abnormal_tongue_morphology0.99133858
89MP0004947_skin_inflammation0.98292619
90MP0000377_abnormal_hair_follicle0.98025209
91MP0005503_abnormal_tendon_morphology0.97701102
92MP0000427_abnormal_hair_cycle0.95570255
93MP0008872_abnormal_physiological_respon0.93282001
94MP0003136_yellow_coat_color0.93106883
95MP0009384_cardiac_valve_regurgitation0.92970690
96MP0001485_abnormal_pinna_reflex0.89131561
97MP0003868_abnormal_feces_composition0.86711704
98MP0005584_abnormal_enzyme/coenzyme_acti0.86444841
99MP0002734_abnormal_mechanical_nocicepti0.82116490
100MP0005310_abnormal_salivary_gland0.80137105
101MP0000598_abnormal_liver_morphology0.79574420
102MP0001191_abnormal_skin_condition0.78694998
103MP0003724_increased_susceptibility_to0.77768003
104MP0003075_altered_response_to0.76331195
105MP0004185_abnormal_adipocyte_glucose0.75572842
106MP0005636_abnormal_mineral_homeostasis0.73932430
107MP0009697_abnormal_copulation0.73805047
108MP0001756_abnormal_urination0.73147106
109MP0009765_abnormal_xenobiotic_induced0.72805064
110MP0002295_abnormal_pulmonary_circulatio0.72407546
111MP0004885_abnormal_endolymph0.71552919
112MP0009931_abnormal_skin_appearance0.70881291
113MP0001915_intracranial_hemorrhage0.70325933
114MP0000538_abnormal_urinary_bladder0.70004235
115MP0003279_aneurysm0.69555550
116MP0001270_distended_abdomen0.68900983
117MP0001663_abnormal_digestive_system0.68853059
118MP0004272_abnormal_basement_membrane0.68772221
119MP0005220_abnormal_exocrine_pancreas0.67101178
120MP0010352_gastrointestinal_tract_polyps0.65644993
121MP0001664_abnormal_digestion0.65270181
122* MP0009763_increased_sensitivity_to0.65073705
123MP0003866_abnormal_defecation0.64826142
124MP0005389_reproductive_system_phenotype0.64628172
125MP0004782_abnormal_surfactant_physiolog0.64006200
126MP0000026_abnormal_inner_ear0.63473740
127MP0005084_abnormal_gallbladder_morpholo0.63318664
128MP0005165_increased_susceptibility_to0.63147096
129MP0000367_abnormal_coat/_hair0.59911911
130MP0002896_abnormal_bone_mineralization0.59474856
131MP0003828_pulmonary_edema0.59267970
132MP0001340_abnormal_eyelid_morphology0.58969931
133MP0002136_abnormal_kidney_physiology0.58521781
134MP0002282_abnormal_trachea_morphology0.57891260
135MP0003300_gastrointestinal_ulcer0.57762850
136MP0005387_immune_system_phenotype0.57680849
137MP0001790_abnormal_immune_system0.57680849
138MP0001929_abnormal_gametogenesis0.57474055
139MP0002249_abnormal_larynx_morphology0.56272304
140MP0002405_respiratory_system_inflammati0.56074012
141MP0001958_emphysema0.55205836
142MP0005164_abnormal_response_to0.54669728
143MP0003698_abnormal_male_reproductive0.54627551
144MP0001849_ear_inflammation0.54416888
145MP0002638_abnormal_pupillary_reflex0.54331932
146MP0001502_abnormal_circadian_rhythm0.53018934
147MP0002735_abnormal_chemical_nociception0.52684572
148MP0001764_abnormal_homeostasis0.52471329
149MP0003656_abnormal_erythrocyte_physiolo0.52252296
150MP0005376_homeostasis/metabolism_phenot0.51341454
151MP0000613_abnormal_salivary_gland0.49428360
152MP0003890_abnormal_embryonic-extraembry0.48986317
153MP0005409_darkened_coat_color0.47813375
154MP0003937_abnormal_limbs/digits/tail_de0.46813852
155MP0005388_respiratory_system_phenotype0.45787260
156MP0002133_abnormal_respiratory_system0.45787260
157MP0000477_abnormal_intestine_morphology0.42367663
158MP0002822_catalepsy0.42261735

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)8.50957216
2Bronchiectasis (HP:0002110)7.43055407
3Nasal polyposis (HP:0100582)6.74425894
4Deep venous thrombosis (HP:0002625)5.76022336
5Intrahepatic cholestasis (HP:0001406)5.72988291
6Abnormality of the nasal mucosa (HP:0000433)5.59426724
7Xanthomatosis (HP:0000991)5.31809447
8Abnormality of aromatic amino acid family metabolism (HP:0004338)5.30753941
9Abnormality of monocarboxylic acid metabolism (HP:0010996)5.07950736
10Hypobetalipoproteinemia (HP:0003563)4.54075996
11Bronchitis (HP:0012387)4.47869485
12Prolonged partial thromboplastin time (HP:0003645)4.43345781
13Recurrent sinusitis (HP:0011108)4.25719215
14Infertility (HP:0000789)4.18075593
15Hyperactive renin-angiotensin system (HP:0000841)4.13250295
16Chronic sinusitis (HP:0011109)4.07294853
17Hypoalphalipoproteinemia (HP:0003233)4.02025596
18Abnormality of fatty-acid metabolism (HP:0004359)4.01870996
19Hypolipoproteinemia (HP:0010981)3.98003348
20Complement deficiency (HP:0004431)3.97407639
21Male infertility (HP:0003251)3.94527226
22Distal lower limb muscle weakness (HP:0009053)3.89511462
23Hyperlipoproteinemia (HP:0010980)3.86327476
24Recurrent otitis media (HP:0000403)3.80852012
25Right ventricular cardiomyopathy (HP:0011663)3.55718719
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.54746492
27Epidermoid cyst (HP:0200040)3.47183161
28Abnormality of the common coagulation pathway (HP:0010990)3.42440599
29Occipital encephalocele (HP:0002085)3.41520700
30Myocardial infarction (HP:0001658)3.38846927
31Pancreatic fibrosis (HP:0100732)3.33937860
32Abnormality of complement system (HP:0005339)3.31695169
33Onycholysis (HP:0001806)3.29281022
34Hyperglycinemia (HP:0002154)3.25968167
35True hermaphroditism (HP:0010459)3.25593285
36Chronic otitis media (HP:0000389)3.08474040
37Joint hemorrhage (HP:0005261)3.08266483
38Abnormal hemoglobin (HP:0011902)3.08222497
39Hypoglycemic coma (HP:0001325)3.06323537
40Fat malabsorption (HP:0002630)3.03400635
41Ketosis (HP:0001946)2.93384917
42Hyperammonemia (HP:0001987)2.92240399
43Atelectasis (HP:0100750)2.90333636
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.89839318
45Abnormality of methionine metabolism (HP:0010901)2.88463093
46Abnormality of glycine metabolism (HP:0010895)2.81032552
47Abnormality of serine family amino acid metabolism (HP:0010894)2.81032552
48Cystic liver disease (HP:0006706)2.80364805
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.79199237
50Alopecia of scalp (HP:0002293)2.78294615
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.74438378
52Pancreatic cysts (HP:0001737)2.71758695
53Vascular calcification (HP:0004934)2.71580511
54Molar tooth sign on MRI (HP:0002419)2.70233033
55Abnormality of midbrain morphology (HP:0002418)2.70233033
56Conjugated hyperbilirubinemia (HP:0002908)2.70138923
57Plantar hyperkeratosis (HP:0007556)2.69901209
58Impaired platelet aggregation (HP:0003540)2.69714028
59Abnormal platelet function (HP:0011869)2.69714028
60Hyperglycinuria (HP:0003108)2.67521056
61Cardiovascular calcification (HP:0011915)2.63800332
62Spastic diplegia (HP:0001264)2.63235263
63Abnormality of the intrinsic pathway (HP:0010989)2.57802555
64Hepatocellular carcinoma (HP:0001402)2.56478687
65Hypercholesterolemia (HP:0003124)2.55697663
66Nephronophthisis (HP:0000090)2.55209608
67Gout (HP:0001997)2.53543829
68Hypokalemic alkalosis (HP:0001949)2.49743115
69Increased circulating renin level (HP:0000848)2.47053079
70Esophageal varix (HP:0002040)2.40913794
71Peritonitis (HP:0002586)2.39877061
72Postaxial foot polydactyly (HP:0001830)2.32489882
73Scanning speech (HP:0002168)2.30013873
74Chronic hepatic failure (HP:0100626)2.28112347
75Premature rupture of membranes (HP:0001788)2.26759610
76Protrusio acetabuli (HP:0003179)2.26742715
77Renal salt wasting (HP:0000127)2.25302621
78Ketoacidosis (HP:0001993)2.25024047
79Decreased circulating renin level (HP:0003351)2.24322610
80Atrophic scars (HP:0001075)2.23518258
81Palmoplantar hyperkeratosis (HP:0000972)2.23394256
82Steatorrhea (HP:0002570)2.23329410
83Hyperkalemia (HP:0002153)2.21447594
84Alkalosis (HP:0001948)2.20251741
85Amyloidosis (HP:0011034)2.20084399
86Chondrocalcinosis (HP:0000934)2.18285742
87Delayed CNS myelination (HP:0002188)2.17214815
88Abnormality of purine metabolism (HP:0004352)2.15027381
89Increased connective tissue (HP:0009025)2.13906076
90Tubulointerstitial nephritis (HP:0001970)2.11268686
91Abnormality of chloride homeostasis (HP:0011422)2.10201515
92Abnormality of nucleobase metabolism (HP:0010932)2.09339979
93Fragile nails (HP:0001808)2.07937150
94Tetany (HP:0001281)2.06445845
95Abnormality of the renal medulla (HP:0100957)2.06215499
96Mitral stenosis (HP:0001718)2.05192791
97Abnormality of Sharpey fibers (HP:0100685)2.03977101
98Skin nodule (HP:0200036)2.02614588
99Abnormality of the Achilles tendon (HP:0005109)2.01804990
100Hyperbilirubinemia (HP:0002904)2.01318210
101Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00972022
102Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.1339165
103Abnormal respiratory epithelium morphology (HP:0012253)10.9389425
104Abnormal respiratory motile cilium morphology (HP:0005938)10.9389425
105Abnormal respiratory motile cilium physiology (HP:0012261)10.7885474
106Absent/shortened dynein arms (HP:0200106)10.6123555
107Dynein arm defect of respiratory motile cilia (HP:0012255)10.6123555
108Abnormal ciliary motility (HP:0012262)10.4203849
109Rhinitis (HP:0012384)10.0656124
110Palmar hyperkeratosis (HP:0010765)1.99944129
111Hypoglycemic seizures (HP:0002173)1.99912172
112Large eyes (HP:0001090)1.99661525
113Acanthosis nigricans (HP:0000956)1.98438548
114Abnormality of pyrimidine metabolism (HP:0004353)1.97965176
115Abnormality of serum amino acid levels (HP:0003112)1.97075154
116Hyperaldosteronism (HP:0000859)1.96053977
117Renal cortical cysts (HP:0000803)1.93673089
118Congenital hepatic fibrosis (HP:0002612)1.92811405
119Bell-shaped thorax (HP:0001591)1.92305690
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.92226185
121Woolly hair (HP:0002224)1.91924635
122Male pseudohermaphroditism (HP:0000037)1.88973035
123Lip pit (HP:0100267)1.87651000
124Spontaneous abortion (HP:0005268)1.86696324
125Fragile skin (HP:0001030)1.86229725
126Increased mean platelet volume (HP:0011877)1.86116680
127Anencephaly (HP:0002323)1.85609949
128Hyperglycemia (HP:0003074)1.83302238
129Neonatal onset (HP:0003623)1.81537245
130Metabolic acidosis (HP:0001942)1.81129055
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.80785298
132Osteolytic defects of the hand bones (HP:0009699)1.80785298
133Glomerulosclerosis (HP:0000096)1.80498670
134Metabolic alkalosis (HP:0200114)1.79623620
135Hypotrichosis (HP:0001006)1.77376955
136Furrowed tongue (HP:0000221)1.77302116
137Medial flaring of the eyebrow (HP:0010747)1.77068217
138Rickets (HP:0002748)1.77024313
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.76655424
140Abnormality of renin-angiotensin system (HP:0000847)1.76554730
141Bifid scrotum (HP:0000048)1.76242490
142Pancreatitis (HP:0001733)1.73051724
143Abnormal blistering of the skin (HP:0008066)1.72973342
144Nephropathy (HP:0000112)1.72942758
145Recurrent bronchitis (HP:0002837)1.70746670
146Absent frontal sinuses (HP:0002688)1.70509444
147Asplenia (HP:0001746)1.64033826
148Congenital primary aphakia (HP:0007707)1.63656765
149Gait imbalance (HP:0002141)1.61798166
150Tubular atrophy (HP:0000092)1.59922575
151Hyponatremia (HP:0002902)1.59437003
152Sclerocornea (HP:0000647)1.58669330
153Oculomotor apraxia (HP:0000657)1.50446140
154Postaxial hand polydactyly (HP:0001162)1.49478108
155Nephrogenic diabetes insipidus (HP:0009806)1.42042475
156Abnormality of permanent molar morphology (HP:0011071)1.40645094
157Abnormality of the dental root (HP:0006486)1.40645094
158Taurodontia (HP:0000679)1.40645094
159Median cleft lip (HP:0000161)1.37716074
160Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.33960632
161Abnormality of the distal phalanges of the toes (HP:0010182)1.33839868
162Abnormality of molar morphology (HP:0011070)1.29445122
163Abnormality of molar (HP:0011077)1.29445122
164Popliteal pterygium (HP:0009756)1.28149340
165Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.26994588
166Absent rod-and cone-mediated responses on ERG (HP:0007688)1.25951612
167Abnormality of the dental pulp (HP:0006479)1.25280980
168Abnormality of sodium homeostasis (HP:0010931)1.22161750
169Short thorax (HP:0010306)1.21290933
170Preaxial hand polydactyly (HP:0001177)1.21250753
171Glucose intolerance (HP:0000833)1.19435484
172Tubulointerstitial abnormality (HP:0001969)1.17476170
173Short femoral neck (HP:0100864)1.12390021
174Hand muscle atrophy (HP:0009130)1.11262764
175Decreased central vision (HP:0007663)1.09814242
176Spinal muscular atrophy (HP:0007269)1.09512207
177Stage 5 chronic kidney disease (HP:0003774)1.09342250
178Vaginal atresia (HP:0000148)1.07362903
179Genital tract atresia (HP:0001827)1.07060961
180Obstructive sleep apnea (HP:0002870)1.06937901
181Tubulointerstitial fibrosis (HP:0005576)1.05691679
182Fetal akinesia sequence (HP:0001989)1.05500584
183Recurrent corneal erosions (HP:0000495)1.05466868
184Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.05134467
185Abnormality of the frontal sinuses (HP:0002687)1.04512223
186Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.03294754
187Poor coordination (HP:0002370)1.02629376
188Adrenal overactivity (HP:0002717)1.01061718
189Carpal bone hypoplasia (HP:0001498)1.01005351
190Flat acetabular roof (HP:0003180)0.99786241
191Limb-girdle muscle atrophy (HP:0003797)0.99754937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK15.25323327
2MST43.96852814
3SIK33.73765404
4MST1R3.46248360
5ERN13.41184946
6SMG12.60000588
7FER2.50469673
8BCKDK2.45469747
9LATS12.32875934
10MAP3K32.29655198
11NME12.24726309
12TTN2.10165119
13SIK22.02399573
14STK242.00849028
15LRRK22.00634337
16TRPM71.89882198
17EPHB21.78041285
18SGK31.77112157
19TTK1.73099883
20RPS6KB21.69254452
21ERBB41.65341294
22FGFR41.63957893
23STK101.63731568
24MAPKAPK31.55437757
25INSRR1.54990158
26PBK1.54672227
27TRIB31.53515184
28STK38L1.52424007
29TYRO31.47044660
30ERBB31.45667389
31NEK91.43502270
32CDK61.40569903
33MET1.38582132
34SGK21.38135839
35NEK61.37281241
36PKN21.33404108
37MAP3K21.29681885
38PTK2B1.29284090
39TLK11.28551179
40EPHA21.28370944
41PDK21.24884866
42FRK1.23951805
43MAP2K31.21966708
44PIK3CG1.21801448
45PTK61.21131742
46BCR1.15549418
47TNK21.15471817
48ADRBK21.13176692
49DDR21.07493291
50SGK2231.06706492
51SGK4941.06706492
52PTK21.04993699
53ICK1.03961728
54MARK31.03876791
55TAOK11.01317522
56GRK61.00820974
57BRSK20.99707653
58EEF2K0.98743811
59TBK10.98597111
60MAP2K10.93020362
61LATS20.92439376
62MAP3K70.92417568
63PAK30.89759030
64TAOK20.89101249
65MAP2K20.87998466
66MAP3K120.86575523
67FGFR20.83439059
68PRKCI0.83145772
69PNCK0.77779926
70RIPK40.77376162
71PDK30.76659710
72PDK40.76659710
73TGFBR20.72581367
74TYK20.71683940
75EPHA30.70894238
76DAPK20.68866239
77CAMKK10.62237532
78ERBB20.61137958
79FLT30.60561679
80TESK10.59649164
81EPHB10.59327252
82DYRK1B0.58496820
83PRKCD0.58123996
84MAP3K110.57038936
85ADRBK10.56559116
86MAP2K40.55987838
87PRKD10.55201076
88STK30.52005388
89RPS6KA40.51467941
90ABL20.49849596
91MAPK150.49652705
92BMX0.49478068
93TAOK30.47452430
94MUSK0.45842108
95JAK10.45111503
96IRAK30.43684123
97STK160.43601568
98RIPK10.43090268
99PRKCQ0.42670714
100MAPK110.41834711
101PDGFRA0.41820285
102AURKA0.41782753
103IRAK10.41634084
104MAP3K10.40623373
105HIPK20.40555062
106ZAP700.40261877
107CAMK2G0.39242212
108FGFR10.38677843
109SGK10.38030637
110LMTK20.37199322
111PRKG20.36263035
112PAK20.36079474
113PDGFRB0.35964390
114JAK20.35310024
115NLK0.35143167
116LIMK10.33709446
117CSK0.33226927
118BMPR20.32180209
119TGFBR10.32034064
120MAP3K40.31062775
121IGF1R0.30732881
122MARK20.30161279
123PRKAA20.29829936
124MAP4K20.29670884
125ABL10.29565109
126MYLK0.28734931
127MAP3K140.27741466
128MAP2K60.27540994
129MAPKAPK50.27390936
130GRK10.27290930
131PDPK10.27085443
132PRKCA0.26889403
133MAP3K80.26153625
134NME20.25664168
135PIK3CA0.25076270
136SRC0.24660340
137FYN0.24005223
138STK380.24005053
139PRKACA0.23728892
140STK390.23607424
141OXSR10.23399005
142FGFR30.23255014
143STK40.23106738
144MAP3K60.22769596
145MAP2K70.21771445
146MATK0.20709625
147MAPK130.19565909
148IKBKE0.19218870
149CDC42BPA0.18427839
150WNK40.17763013
151PIM20.16840502
152BLK0.13853076
153CAMKK20.13806748
154ROCK10.13625409
155EGFR0.12925756
156ROCK20.11518497
157PRKCH0.11381524

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.92860965
2* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.68222034
3* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.45937080
4* Chemical carcinogenesis_Homo sapiens_hsa052043.18639265
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07701582
6Phenylalanine metabolism_Homo sapiens_hsa003602.80998026
7Histidine metabolism_Homo sapiens_hsa003402.75283283
8Sulfur metabolism_Homo sapiens_hsa009202.55460212
9Nitrogen metabolism_Homo sapiens_hsa009102.55374597
10Complement and coagulation cascades_Homo sapiens_hsa046102.45795084
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43480580
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41162900
13Arginine biosynthesis_Homo sapiens_hsa002202.34729834
14* Fatty acid degradation_Homo sapiens_hsa000712.25993714
15Tryptophan metabolism_Homo sapiens_hsa003802.22718330
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21725486
17beta-Alanine metabolism_Homo sapiens_hsa004102.19375346
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09442593
19* Tyrosine metabolism_Homo sapiens_hsa003502.04717787
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02700633
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01694262
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00723643
23* Retinol metabolism_Homo sapiens_hsa008301.92849942
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89544443
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.87964690
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.87577030
27Huntingtons disease_Homo sapiens_hsa050161.79906585
28Peroxisome_Homo sapiens_hsa041461.71238988
29Selenocompound metabolism_Homo sapiens_hsa004501.67399197
30Caffeine metabolism_Homo sapiens_hsa002321.65464465
31Fatty acid metabolism_Homo sapiens_hsa012121.63860725
32Sulfur relay system_Homo sapiens_hsa041221.58487138
33Butanoate metabolism_Homo sapiens_hsa006501.55634026
34Propanoate metabolism_Homo sapiens_hsa006401.53892847
35PPAR signaling pathway_Homo sapiens_hsa033201.52914666
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45927229
37Glutathione metabolism_Homo sapiens_hsa004801.43753861
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35658150
39Fatty acid elongation_Homo sapiens_hsa000621.30876946
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30423006
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26216304
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.25620605
43Staphylococcus aureus infection_Homo sapiens_hsa051501.25505001
44Bile secretion_Homo sapiens_hsa049761.23189791
45Sphingolipid metabolism_Homo sapiens_hsa006001.17082905
46Steroid biosynthesis_Homo sapiens_hsa001001.15383086
47Fat digestion and absorption_Homo sapiens_hsa049751.07168896
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.05778028
49* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03721410
50Starch and sucrose metabolism_Homo sapiens_hsa005001.01438444
51ABC transporters_Homo sapiens_hsa020100.99252989
52Pyruvate metabolism_Homo sapiens_hsa006200.97058475
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96462748
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.87808907
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87428416
56Carbon metabolism_Homo sapiens_hsa012000.83725272
57Folate biosynthesis_Homo sapiens_hsa007900.79426435
58Vitamin digestion and absorption_Homo sapiens_hsa049770.78581047
59Biosynthesis of amino acids_Homo sapiens_hsa012300.77667003
60Circadian rhythm_Homo sapiens_hsa047100.70925863
61Salivary secretion_Homo sapiens_hsa049700.70060064
62Collecting duct acid secretion_Homo sapiens_hsa049660.69464633
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65206490
64Glycerolipid metabolism_Homo sapiens_hsa005610.64559072
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.63802802
66One carbon pool by folate_Homo sapiens_hsa006700.62463511
67Taste transduction_Homo sapiens_hsa047420.61703936
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61067307
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58549559
70Fatty acid biosynthesis_Homo sapiens_hsa000610.58363163
71Lysine degradation_Homo sapiens_hsa003100.56294371
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54760992
73Notch signaling pathway_Homo sapiens_hsa043300.44045052
74Arginine and proline metabolism_Homo sapiens_hsa003300.43927005
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42502915
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41723609
77Olfactory transduction_Homo sapiens_hsa047400.40669523
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40249669
79Phototransduction_Homo sapiens_hsa047440.39888135
80Vitamin B6 metabolism_Homo sapiens_hsa007500.39569712
81Bladder cancer_Homo sapiens_hsa052190.36849438
82Hematopoietic cell lineage_Homo sapiens_hsa046400.36708919
83Linoleic acid metabolism_Homo sapiens_hsa005910.35560914
84Arachidonic acid metabolism_Homo sapiens_hsa005900.32807176
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32453148
86ECM-receptor interaction_Homo sapiens_hsa045120.32256065
87Choline metabolism in cancer_Homo sapiens_hsa052310.30959752
88Lysosome_Homo sapiens_hsa041420.30231610
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.29546759
90* Metabolic pathways_Homo sapiens_hsa011000.29346459
91Adherens junction_Homo sapiens_hsa045200.27850983
92Pentose phosphate pathway_Homo sapiens_hsa000300.26708435
93Hedgehog signaling pathway_Homo sapiens_hsa043400.26482893
94Vibrio cholerae infection_Homo sapiens_hsa051100.24730108
95Type I diabetes mellitus_Homo sapiens_hsa049400.23953626
96Autoimmune thyroid disease_Homo sapiens_hsa053200.23820924
97Asthma_Homo sapiens_hsa053100.22311010
98Allograft rejection_Homo sapiens_hsa053300.21853676
99Amoebiasis_Homo sapiens_hsa051460.20419224
100Pancreatic secretion_Homo sapiens_hsa049720.19938743
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19605713
102Basal cell carcinoma_Homo sapiens_hsa052170.19277198
103Graft-versus-host disease_Homo sapiens_hsa053320.19236409
104Cardiac muscle contraction_Homo sapiens_hsa042600.18982560
105Insulin resistance_Homo sapiens_hsa049310.18710153
106Gastric acid secretion_Homo sapiens_hsa049710.18046473
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.17666701
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.17630589
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17373046
110Prion diseases_Homo sapiens_hsa050200.15790433
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15580466
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15031508
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13648107
114Regulation of autophagy_Homo sapiens_hsa041400.13455347
115Proteoglycans in cancer_Homo sapiens_hsa052050.12562805
116Cocaine addiction_Homo sapiens_hsa050300.12340084
117Antigen processing and presentation_Homo sapiens_hsa046120.11557806
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.10172580
119cAMP signaling pathway_Homo sapiens_hsa040240.09590335
120Nicotine addiction_Homo sapiens_hsa050330.09587522
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.09105804
122Phagosome_Homo sapiens_hsa041450.09023722
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.08395542
124Fructose and mannose metabolism_Homo sapiens_hsa000510.08011751
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07812973
126Rheumatoid arthritis_Homo sapiens_hsa053230.07666963
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07473670
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07371472
129Thyroid hormone synthesis_Homo sapiens_hsa049180.07252399
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.07099441
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06988501
132Dilated cardiomyopathy_Homo sapiens_hsa054140.05989867
133Glucagon signaling pathway_Homo sapiens_hsa049220.05727772
134Ovarian steroidogenesis_Homo sapiens_hsa049130.05649077
135Galactose metabolism_Homo sapiens_hsa000520.05457735
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.05088928
137Calcium signaling pathway_Homo sapiens_hsa040200.04922041
138Tight junction_Homo sapiens_hsa045300.04725101
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.02044623
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.01839433
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.01748909
142TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0779139
143Hepatitis C_Homo sapiens_hsa05160-0.0763974
144Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.0688085
145Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0648467
146AMPK signaling pathway_Homo sapiens_hsa04152-0.0474740
147Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0389768
148Pertussis_Homo sapiens_hsa05133-0.0380460
149Mineral absorption_Homo sapiens_hsa04978-0.0368498
150Focal adhesion_Homo sapiens_hsa04510-0.0067916
151Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0039782
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0001064

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