ADI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.74770953
2L-phenylalanine catabolic process (GO:0006559)7.74770953
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.37272863
4L-phenylalanine metabolic process (GO:0006558)7.37272863
5exogenous drug catabolic process (GO:0042738)7.21088650
6drug catabolic process (GO:0042737)6.87444422
7epoxygenase P450 pathway (GO:0019373)6.55210438
8aromatic amino acid family catabolic process (GO:0009074)6.09800883
9omega-hydroxylase P450 pathway (GO:0097267)5.85414183
10fibrinolysis (GO:0042730)5.20314094
11glyoxylate metabolic process (GO:0046487)5.09746854
12bile acid biosynthetic process (GO:0006699)4.95826184
13alpha-linolenic acid metabolic process (GO:0036109)4.72468201
14cysteine metabolic process (GO:0006534)4.66385886
15sulfur amino acid catabolic process (GO:0000098)4.64195613
16indolalkylamine catabolic process (GO:0046218)4.64105044
17tryptophan catabolic process (GO:0006569)4.64105044
18indole-containing compound catabolic process (GO:0042436)4.64105044
19oxidative demethylation (GO:0070989)4.61916267
20tryptophan metabolic process (GO:0006568)4.56201300
21aromatic amino acid family metabolic process (GO:0009072)4.53678753
22kynurenine metabolic process (GO:0070189)4.44978627
23ethanol metabolic process (GO:0006067)4.42278101
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.38395628
25tyrosine metabolic process (GO:0006570)4.37999608
26fatty acid elongation (GO:0030497)4.32241820
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.24483749
28bile acid metabolic process (GO:0008206)4.23737836
29negative regulation of blood coagulation (GO:0030195)4.22325491
30negative regulation of hemostasis (GO:1900047)4.22325491
31protein carboxylation (GO:0018214)4.14429235
32peptidyl-glutamic acid carboxylation (GO:0017187)4.14429235
33coenzyme catabolic process (GO:0009109)4.12828989
34negative regulation of cholesterol transport (GO:0032375)4.10220631
35negative regulation of sterol transport (GO:0032372)4.10220631
36high-density lipoprotein particle remodeling (GO:0034375)4.08746003
37serine family amino acid biosynthetic process (GO:0009070)4.08236470
38flavonoid metabolic process (GO:0009812)4.05254697
39fat-soluble vitamin biosynthetic process (GO:0042362)4.00252513
40alpha-amino acid catabolic process (GO:1901606)3.98374995
41aldehyde catabolic process (GO:0046185)3.96308321
42phenylpropanoid metabolic process (GO:0009698)3.94656581
43negative regulation of coagulation (GO:0050819)3.92629705
44regulation of plasminogen activation (GO:0010755)3.92221142
45daunorubicin metabolic process (GO:0044597)3.86524634
46polyketide metabolic process (GO:0030638)3.86524634
47doxorubicin metabolic process (GO:0044598)3.86524634
48negative regulation of fibrinolysis (GO:0051918)3.85213333
49regulation of fibrinolysis (GO:0051917)3.84329983
50serine family amino acid catabolic process (GO:0009071)3.83619197
51serine family amino acid metabolic process (GO:0009069)3.81180201
52cellular amino acid catabolic process (GO:0009063)3.80011079
53very long-chain fatty acid metabolic process (GO:0000038)3.77464288
54protein activation cascade (GO:0072376)3.74443076
55regulation of protein activation cascade (GO:2000257)3.72158456
56L-serine metabolic process (GO:0006563)3.72050901
57amino-acid betaine metabolic process (GO:0006577)3.70465922
58glycine metabolic process (GO:0006544)3.70235511
59heme transport (GO:0015886)3.70198696
60lysine catabolic process (GO:0006554)3.69712432
61lysine metabolic process (GO:0006553)3.69712432
62urea metabolic process (GO:0019627)3.68831523
63urea cycle (GO:0000050)3.68831523
64regulation of cholesterol esterification (GO:0010872)3.68748510
65complement activation, alternative pathway (GO:0006957)3.68626238
66cofactor catabolic process (GO:0051187)3.68308700
67short-chain fatty acid metabolic process (GO:0046459)3.63625704
68triglyceride homeostasis (GO:0070328)3.63433058
69acylglycerol homeostasis (GO:0055090)3.63433058
70negative regulation of wound healing (GO:0061045)3.61836112
71regulation of triglyceride catabolic process (GO:0010896)3.61087599
72ethanol oxidation (GO:0006069)3.58483908
73amine catabolic process (GO:0009310)3.57579538
74cellular biogenic amine catabolic process (GO:0042402)3.57579538
75response to nitrosative stress (GO:0051409)3.55754339
76cellular glucuronidation (GO:0052695)3.55203668
77homocysteine metabolic process (GO:0050667)3.55125787
78fatty acid beta-oxidation (GO:0006635)3.54723405
79S-adenosylmethionine metabolic process (GO:0046500)3.53568852
80aminoglycoside antibiotic metabolic process (GO:0030647)3.52239958
81organic acid catabolic process (GO:0016054)3.52001111
82carboxylic acid catabolic process (GO:0046395)3.52001111
83xenobiotic catabolic process (GO:0042178)3.51967584
84aspartate family amino acid catabolic process (GO:0009068)3.51588774
85cellular ketone body metabolic process (GO:0046950)3.50902424
86arginine metabolic process (GO:0006525)3.50691397
87drug transmembrane transport (GO:0006855)3.50220699
88imidazole-containing compound metabolic process (GO:0052803)3.50129395
89reverse cholesterol transport (GO:0043691)3.49587377
90cellular modified amino acid catabolic process (GO:0042219)3.49526071
91nitrogen cycle metabolic process (GO:0071941)3.49200367
92indolalkylamine metabolic process (GO:0006586)3.49098795
93branched-chain amino acid catabolic process (GO:0009083)3.47111388
94regulation of complement activation (GO:0030449)3.47095221
95fatty acid catabolic process (GO:0009062)3.46629299
96complement activation (GO:0006956)3.46176491
97alkaloid metabolic process (GO:0009820)3.45495965
98intestinal cholesterol absorption (GO:0030299)3.45374924
99complement activation, classical pathway (GO:0006958)3.44825694
100plasma lipoprotein particle remodeling (GO:0034369)3.43358507
101protein-lipid complex remodeling (GO:0034368)3.43358507
102macromolecular complex remodeling (GO:0034367)3.43358507
103fatty acid oxidation (GO:0019395)3.41804813
104monocarboxylic acid catabolic process (GO:0072329)3.39900509
105primary alcohol catabolic process (GO:0034310)3.39258403
106regulation of cholesterol metabolic process (GO:0090181)3.39154137
107very-low-density lipoprotein particle assembly (GO:0034379)3.39005588
108NADH metabolic process (GO:0006734)3.37811668
109benzene-containing compound metabolic process (GO:0042537)3.37223020
110fatty-acyl-CoA biosynthetic process (GO:0046949)3.36976823
111phospholipid efflux (GO:0033700)3.36805328
112negative regulation of protein activation cascade (GO:2000258)3.36778257
113positive regulation of cellular amine metabolic process (GO:0033240)3.36090859
114regulation of cholesterol biosynthetic process (GO:0045540)3.36058198
115blood coagulation, intrinsic pathway (GO:0007597)3.34534718
116glutamate metabolic process (GO:0006536)3.34233861
117positive regulation of hemostasis (GO:1900048)3.33290808
118positive regulation of blood coagulation (GO:0030194)3.33290808
119lipid oxidation (GO:0034440)3.33157688
120bile acid and bile salt transport (GO:0015721)3.29590404
121xenobiotic metabolic process (GO:0006805)3.29144642
122glucuronate metabolic process (GO:0019585)3.27572517
123uronic acid metabolic process (GO:0006063)3.27572517
124acute-phase response (GO:0006953)3.26644031
125axon ensheathment in central nervous system (GO:0032291)3.21243066
126central nervous system myelination (GO:0022010)3.21243066
127long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.20868956
128acetyl-CoA metabolic process (GO:0006084)3.20793626
129branched-chain amino acid metabolic process (GO:0009081)3.19811689
130signal peptide processing (GO:0006465)3.19434418
131drug metabolic process (GO:0017144)3.18618950
132plasma lipoprotein particle clearance (GO:0034381)3.17355915
133cholesterol efflux (GO:0033344)3.15609984
134acyl-CoA metabolic process (GO:0006637)3.13691974
135thioester metabolic process (GO:0035383)3.13691974
136positive regulation of lipoprotein lipase activity (GO:0051006)3.13306119
137positive regulation of triglyceride lipase activity (GO:0061365)3.13306119
138positive regulation of coagulation (GO:0050820)3.11859410
139response to mercury ion (GO:0046689)3.08990761
140hormone catabolic process (GO:0042447)3.00926002
141regulation of humoral immune response (GO:0002920)2.99439958
142low-density lipoprotein particle remodeling (GO:0034374)2.96908380
143negative regulation of complement activation (GO:0045916)2.93643932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.20635177
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.56021317
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.70066904
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.57225370
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.95703787
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.82980585
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.19523458
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.14035776
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.58941542
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.60278303
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.59590504
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36981508
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31669119
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.15850963
15GATA1_22025678_ChIP-Seq_K562_Human2.10457150
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09056639
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99574697
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97450823
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95620434
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92269067
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.85611651
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79378880
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77409247
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71522406
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71322015
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.69407032
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68851168
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63328322
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.57974508
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.56554789
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52225070
32HTT_18923047_ChIP-ChIP_STHdh_Human1.50941666
33* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.45192812
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40982996
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39952195
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.39577468
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36948795
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33790754
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.27164839
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.27098617
41PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26733924
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.23998554
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.22611341
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.21383465
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20430055
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19446853
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16728042
48GATA6_25053715_ChIP-Seq_YYC3_Human1.16139138
49LXR_22292898_ChIP-Seq_THP-1_Human1.15357754
50SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14927302
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13377984
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12367404
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10179947
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.09855321
55* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08915442
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08300468
57* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06744302
58* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05230395
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.04605291
60SOX2_20726797_ChIP-Seq_SW620_Human1.04185318
61IRF1_19129219_ChIP-ChIP_H3396_Human1.02460350
62* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02399597
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01901975
64RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01727967
65* GATA4_25053715_ChIP-Seq_YYC3_Human0.98767007
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98665977
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98572611
68STAT1_20625510_ChIP-Seq_HELA_Human0.97660758
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96623255
70MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96551014
71IRF8_22096565_ChIP-ChIP_GC-B_Human0.96521009
72BCOR_27268052_Chip-Seq_Bcells_Human0.96235596
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95098270
74P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94944113
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92093280
76SCL_19346495_ChIP-Seq_HPC-7_Human0.91640696
77ZNF263_19887448_ChIP-Seq_K562_Human0.91518615
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91322353
79BCL6_27268052_Chip-Seq_Bcells_Human0.90735527
80CLOCK_20551151_ChIP-Seq_293T_Human0.90683470
81TET1_21451524_ChIP-Seq_MESCs_Mouse0.90191120
82GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90178241
83ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90107597
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.89842638
85SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89681273
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89443731
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89307455
88* ELK3_25401928_ChIP-Seq_HUVEC_Human0.89181888
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87834445
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87805837
91* FOXA1_25552417_ChIP-Seq_VCAP_Human0.86683062
92* AR_20517297_ChIP-Seq_VCAP_Human0.86486971
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85270276
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.84592144
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84101547
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84101547
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84025344
98PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83804388
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83730512
100GATA3_24758297_ChIP-Seq_MCF-7_Human0.83448033
101RARB_24833708_ChIP-Seq_LIVER_Mouse0.83389781
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82753283
103CEBPB_22108803_ChIP-Seq_LS180_Human0.82620144
104ERG_20517297_ChIP-Seq_VCAP_Human0.82213088
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82212016
106* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82053599
107RACK7_27058665_Chip-Seq_MCF-7_Human0.81599398
108SPI1_20517297_ChIP-Seq_HL60_Human0.80649236
109* GABP_19822575_ChIP-Seq_HepG2_Human0.80373398
110IRF8_27001747_Chip-Seq_BMDM_Mouse0.79808479
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79554362
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79402202
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78375431
114SOX2_21211035_ChIP-Seq_LN229_Human0.77582817
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77550416
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77388975
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77177517
118P300_27268052_Chip-Seq_Bcells_Human0.77059969
119FOXP3_21729870_ChIP-Seq_TREG_Human0.76882992
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76779387
121SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76747558
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76184594
123GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76047164
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75510063
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75267265
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75215438
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74749038
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.74749038
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.74239792
130DCP1A_22483619_ChIP-Seq_HELA_Human0.73991874
131CJUN_26792858_Chip-Seq_BT549_Human0.73970583
132TBX20_22080862_ChIP-Seq_HEART_Mouse0.73520596
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.73520596
134KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72934743
135VDR_23849224_ChIP-Seq_CD4+_Human0.72658232
136CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72653258
137SOX17_20123909_ChIP-Seq_XEN_Mouse0.72395317
138* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72250238
139* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71928689
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71851372
141HOXB4_20404135_ChIP-ChIP_EML_Mouse0.71109140
142TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70639694
143PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70023506
144MYC_18555785_ChIP-Seq_MESCs_Mouse0.69881069
145FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67832674
146SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67524559
147PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.66736373
148TFEB_21752829_ChIP-Seq_HELA_Human0.65698046
149RARA_24833708_ChIP-Seq_LIVER_Mouse0.65399624
150CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65052005
151TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.65014474
152HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.63209287
153P53_21459846_ChIP-Seq_SAOS-2_Human0.63177860
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.60232803
155CTCF_20526341_ChIP-Seq_ESCs_Human0.59619053
156SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.59455843
157ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.59351317
158GATA1_19941826_ChIP-Seq_K562_Human0.59216040
159AUTS2_25519132_ChIP-Seq_293T-REX_Human0.58374427
160LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.58065523
161CBP_21632823_ChIP-Seq_H3396_Human0.57864960
162PADI4_21655091_ChIP-ChIP_MCF-7_Human0.57857138
163OCT4_20526341_ChIP-Seq_ESCs_Human0.57710613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.15048107
2MP0005360_urolithiasis5.74663148
3MP0005365_abnormal_bile_salt5.67569407
4MP0005085_abnormal_gallbladder_physiolo5.31954193
5MP0003806_abnormal_nucleotide_metabolis5.27511597
6MP0008875_abnormal_xenobiotic_pharmacok4.61159155
7MP0003195_calcinosis4.17157899
8MP0009840_abnormal_foam_cell3.17422660
9MP0005083_abnormal_biliary_tract3.07057009
10MP0003252_abnormal_bile_duct3.04599498
11MP0001666_abnormal_nutrient_absorption2.78857575
12MP0010329_abnormal_lipoprotein_level2.77961956
13MP0005332_abnormal_amino_acid2.71293051
14MP0004043_abnormal_pH_regulation2.18106252
15MP0003186_abnormal_redox_activity2.13138966
16MP0002118_abnormal_lipid_homeostasis2.08249469
17MP0004019_abnormal_vitamin_homeostasis1.99004331
18MP0003868_abnormal_feces_composition1.97466007
19MP0001764_abnormal_homeostasis1.92889914
20MP0003191_abnormal_cellular_cholesterol1.91192683
21MP0000609_abnormal_liver_physiology1.88339321
22MP0002138_abnormal_hepatobiliary_system1.81114236
23MP0005220_abnormal_exocrine_pancreas1.77332868
24MP0009643_abnormal_urine_homeostasis1.75091403
25MP0003656_abnormal_erythrocyte_physiolo1.68219665
26MP0005319_abnormal_enzyme/_coenzyme1.61353701
27MP0005584_abnormal_enzyme/coenzyme_acti1.58862275
28MP0005058_abnormal_lysosome_morphology1.50557775
29MP0006036_abnormal_mitochondrial_physio1.49113136
30MP0005451_abnormal_body_composition1.43899649
31MP0005636_abnormal_mineral_homeostasis1.40624641
32MP0005408_hypopigmentation1.32920124
33MP0000920_abnormal_myelination1.29068191
34MP0004130_abnormal_muscle_cell1.25606414
35MP0003646_muscle_fatigue1.23521194
36MP0002078_abnormal_glucose_homeostasis1.18991187
37MP0001944_abnormal_pancreas_morphology1.18597136
38MP0009697_abnormal_copulation1.17798066
39MP0001661_extended_life_span1.15559074
40MP0002693_abnormal_pancreas_physiology1.15357449
41MP0000598_abnormal_liver_morphology1.08156764
42MP0003011_delayed_dark_adaptation1.02259109
43MP0005084_abnormal_gallbladder_morpholo1.01461232
44MP0003950_abnormal_plasma_membrane0.99363369
45MP0004147_increased_porphyrin_level0.98997189
46MP0003690_abnormal_glial_cell0.98637208
47MP0000751_myopathy0.98615032
48MP0005330_cardiomyopathy0.96688867
49MP0005165_increased_susceptibility_to0.94187058
50MP0000343_altered_response_to0.92340004
51MP0009053_abnormal_anal_canal0.90927853
52MP0003075_altered_response_to0.90839615
53MP0009642_abnormal_blood_homeostasis0.89650211
54MP0003879_abnormal_hair_cell0.88351917
55MP0000639_abnormal_adrenal_gland0.87670299
56MP0005379_endocrine/exocrine_gland_phen0.87489737
57MP0002877_abnormal_melanocyte_morpholog0.86836215
58MP0009763_increased_sensitivity_to0.86627451
59MP0008469_abnormal_protein_level0.86120562
60MP0009785_altered_susceptibility_to0.86068646
61MP0000604_amyloidosis0.85886676
62MP0002148_abnormal_hypersensitivity_rea0.85734002
63MP0001756_abnormal_urination0.84903042
64MP0002332_abnormal_exercise_endurance0.82996461
65MP0009765_abnormal_xenobiotic_induced0.81865790
66MP0005023_abnormal_wound_healing0.81561279
67MP0003329_amyloid_beta_deposits0.79595820
68MP0004264_abnormal_extraembryonic_tissu0.78856741
69MP0000747_muscle_weakness0.78658841
70MP0005376_homeostasis/metabolism_phenot0.77518509
71MP0003436_decreased_susceptibility_to0.76404362
72MP0010155_abnormal_intestine_physiology0.75615300
73MP0002876_abnormal_thyroid_physiology0.75009251
74MP0000249_abnormal_blood_vessel0.73973617
75MP0005075_abnormal_melanosome_morpholog0.73772560
76MP0005647_abnormal_sex_gland0.73752736
77MP0001765_abnormal_ion_homeostasis0.73472231
78MP0001533_abnormal_skeleton_physiology0.73183976
79MP0000013_abnormal_adipose_tissue0.72960987
80MP0005166_decreased_susceptibility_to0.71710406
81MP0008438_abnormal_cutaneous_collagen0.70976705
82MP0004036_abnormal_muscle_relaxation0.68413488
83MP0005266_abnormal_metabolism0.67600419
84MP0005535_abnormal_body_temperature0.64224977
85MP0003953_abnormal_hormone_level0.63851523
86MP0001845_abnormal_inflammatory_respons0.62683553
87MP0004510_myositis0.62249705
88MP0006082_CNS_inflammation0.61977859
89MP0000613_abnormal_salivary_gland0.61597161
90MP0004381_abnormal_hair_follicle0.61407670
91MP0008004_abnormal_stomach_pH0.61107332
92MP0005164_abnormal_response_to0.60747176
93MP0003705_abnormal_hypodermis_morpholog0.60433630
94MP0002837_dystrophic_cardiac_calcinosis0.58872097
95MP0009115_abnormal_fat_cell0.57861043
96MP0000003_abnormal_adipose_tissue0.57618775
97MP0000749_muscle_degeneration0.56931230
98MP0002168_other_aberrant_phenotype0.56898542
99MP0005334_abnormal_fat_pad0.56871019
100MP0002971_abnormal_brown_adipose0.55783987
101MP0000678_abnormal_parathyroid_gland0.55520362
102MP0005167_abnormal_blood-brain_barrier0.55460179
103MP0000462_abnormal_digestive_system0.55044817
104MP0008874_decreased_physiological_sensi0.54612111
105MP0003724_increased_susceptibility_to0.54105852
106MP0000858_altered_metastatic_potential0.53622966
107MP0002419_abnormal_innate_immunity0.53089920
108MP0004233_abnormal_muscle_weight0.52106288
109MP0006035_abnormal_mitochondrial_morpho0.50253946
110MP0005025_abnormal_response_to0.49093717
111MP0008872_abnormal_physiological_respon0.49073799
112MP0001851_eye_inflammation0.48985525
113MP0003638_abnormal_response/metabolism_0.48670189
114MP0009764_decreased_sensitivity_to0.48160145
115MP0002928_abnormal_bile_duct0.47717455
116MP0002136_abnormal_kidney_physiology0.47690305
117MP0009672_abnormal_birth_weight0.47565227
118MP0000230_abnormal_systemic_arterial0.47526110
119MP0008873_increased_physiological_sensi0.45998756
120MP0002132_abnormal_respiratory_system0.45654363
121MP0003718_maternal_effect0.45446454
122MP0000566_synostosis0.45359373
123MP0003959_abnormal_lean_body0.43820502
124MP0010368_abnormal_lymphatic_system0.43760782
125MP0005448_abnormal_energy_balance0.42991023
126MP0004142_abnormal_muscle_tone0.42904452
127MP0005395_other_phenotype0.42404634
128MP0008260_abnormal_autophagy0.41738944
129MP0002229_neurodegeneration0.40074511
130MP0005375_adipose_tissue_phenotype0.39915453
131MP0004885_abnormal_endolymph0.39870856
132MP0005666_abnormal_adipose_tissue0.39055067
133MP0005670_abnormal_white_adipose0.37334636
134MP0000579_abnormal_nail_morphology0.37282838
135MP0005464_abnormal_platelet_physiology0.37134194
136MP0004782_abnormal_surfactant_physiolog0.37039581
137MP0003172_abnormal_lysosome_physiology0.37026337
138MP0003183_abnormal_peptide_metabolism0.36677768

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.67989264
2Intrahepatic cholestasis (HP:0001406)5.92456138
3Systemic lupus erythematosus (HP:0002725)5.77119811
4Prolonged partial thromboplastin time (HP:0003645)5.41203507
5Hypoglycemic coma (HP:0001325)5.27306933
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.10315747
7Deep venous thrombosis (HP:0002625)4.66276602
8Xanthomatosis (HP:0000991)4.65337476
9Hypobetalipoproteinemia (HP:0003563)4.58538785
10Hyperlipoproteinemia (HP:0010980)4.31542434
11Ketosis (HP:0001946)4.20389447
12Hypoglycemic seizures (HP:0002173)3.99558297
13Glomerulonephritis (HP:0000099)3.98896755
14Hyperammonemia (HP:0001987)3.96522882
15Abnormality of the intrinsic pathway (HP:0010989)3.88320403
16Hyperinsulinemic hypoglycemia (HP:0000825)3.83175255
17Hyperglycinemia (HP:0002154)3.81918658
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.78731797
19Abnormality of methionine metabolism (HP:0010901)3.76284676
20Fat malabsorption (HP:0002630)3.70601108
21Abnormality of glycine metabolism (HP:0010895)3.62442342
22Abnormality of serine family amino acid metabolism (HP:0010894)3.62442342
23Ketoacidosis (HP:0001993)3.58477772
24Joint hemorrhage (HP:0005261)3.58441852
25Generalized aminoaciduria (HP:0002909)3.58084226
26Abnormality of fatty-acid metabolism (HP:0004359)3.57668852
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.51495250
28Abnormality of the common coagulation pathway (HP:0010990)3.43173624
29Purpura (HP:0000979)3.39940213
30Hyperglycinuria (HP:0003108)3.35828991
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.32897357
32Complement deficiency (HP:0004431)3.24358126
33Hypolipoproteinemia (HP:0010981)3.23910117
34Symptomatic seizures (HP:0011145)3.21478921
35Dicarboxylic aciduria (HP:0003215)3.18208147
36Abnormality of dicarboxylic acid metabolism (HP:0010995)3.18208147
37Nephritis (HP:0000123)3.18032226
38Steatorrhea (HP:0002570)3.15412328
39Conjugated hyperbilirubinemia (HP:0002908)3.13932744
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.11660839
41Epidermoid cyst (HP:0200040)3.04486455
42Hyperbilirubinemia (HP:0002904)2.97689790
43Abnormality of proline metabolism (HP:0010907)2.97566926
44Hydroxyprolinuria (HP:0003080)2.97566926
45Gout (HP:0001997)2.92777349
46Spontaneous abortion (HP:0005268)2.89300349
47Abnormality of serum amino acid levels (HP:0003112)2.79642404
48Delayed CNS myelination (HP:0002188)2.79465205
49Lethargy (HP:0001254)2.75183816
50Hemorrhage of the eye (HP:0011885)2.73664988
51Hepatic necrosis (HP:0002605)2.69365184
52Metabolic acidosis (HP:0001942)2.69307339
53Late onset (HP:0003584)2.68005755
54Mitral stenosis (HP:0001718)2.64890598
55Pancreatic islet-cell hyperplasia (HP:0004510)2.63065180
56Abnormality of purine metabolism (HP:0004352)2.61987833
57Abnormality of glutamine family amino acid metabolism (HP:0010902)2.61254738
58Cerebral edema (HP:0002181)2.61090151
59Hypoalphalipoproteinemia (HP:0003233)2.60307744
60Abnormality of endocrine pancreas physiology (HP:0012093)2.59703717
61Abnormality of the pancreatic islet cells (HP:0006476)2.59703717
62Glycosuria (HP:0003076)2.56775414
63Abnormality of urine glucose concentration (HP:0011016)2.56775414
64Gingival bleeding (HP:0000225)2.55696239
65Abnormality of nucleobase metabolism (HP:0010932)2.55347739
66Menorrhagia (HP:0000132)2.54177179
67Abnormality of the Achilles tendon (HP:0005109)2.50339297
68Irritability (HP:0000737)2.49237135
69Brushfield spots (HP:0001088)2.47536994
70Opisthotonus (HP:0002179)2.46096754
71Abnormality of pyrimidine metabolism (HP:0004353)2.42067549
72Increased serum ferritin (HP:0003281)2.40473736
73Recurrent gram-negative bacterial infections (HP:0005420)2.39916433
74Cerebral palsy (HP:0100021)2.38049582
75Vascular calcification (HP:0004934)2.37244031
76Dysostosis multiplex (HP:0000943)2.35444955
77Myocardial infarction (HP:0001658)2.33850201
78Urinary glycosaminoglycan excretion (HP:0003541)2.29753333
79Mucopolysacchariduria (HP:0008155)2.29753333
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29618068
81Abnormality of alanine metabolism (HP:0010916)2.29618068
82Hyperalaninemia (HP:0003348)2.29618068
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27666594
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27666594
85Abnormality of polysaccharide metabolism (HP:0011012)2.27666594
86Increased neuronal autofluorescent lipopigment (HP:0002074)2.27383489
87Abnormality of iron homeostasis (HP:0011031)2.22569555
88Hypercholesterolemia (HP:0003124)2.20611005
89Abnormal gallbladder morphology (HP:0012437)2.20215795
90Abnormality of liposaccharide metabolism (HP:0010968)2.20153457
91Abnormality of glycosphingolipid metabolism (HP:0004343)2.20153457
92Abnormality of glycolipid metabolism (HP:0010969)2.20153457
93Increased cerebral lipofuscin (HP:0011813)2.18970565
94Hyperglycemia (HP:0003074)2.18439403
95Abnormality of vitamin metabolism (HP:0100508)2.16315176
96Renal cortical cysts (HP:0000803)2.15812464
97Increased mean platelet volume (HP:0011877)2.14310190
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11260926
99Vomiting (HP:0002013)2.11138078
100Pancreatitis (HP:0001733)2.10613993
101Proximal tubulopathy (HP:0000114)2.10056273
102Acute encephalopathy (HP:0006846)2.09990631
103Abnormality of complement system (HP:0005339)2.09418557
104Nausea (HP:0002018)2.08907029
105Distal lower limb muscle weakness (HP:0009053)2.07895704
106Rhabdomyolysis (HP:0003201)2.06801908
107Methylmalonic aciduria (HP:0012120)2.04899280
108Asymmetric septal hypertrophy (HP:0001670)2.04642181
109Epistaxis (HP:0000421)2.04379413
110Alkalosis (HP:0001948)2.02361744
111Abnormal enzyme/coenzyme activity (HP:0012379)2.01528328
112Spastic paraparesis (HP:0002313)2.00203182
113Hepatocellular carcinoma (HP:0001402)1.99390454
114Vacuolated lymphocytes (HP:0001922)1.98773777
115Rickets (HP:0002748)1.97704242
116Acute hepatic failure (HP:0006554)1.97368004
117Atrioventricular block (HP:0001678)1.96464537
118Cardiovascular calcification (HP:0011915)1.95596614
119Epiphyseal stippling (HP:0010655)1.95098694
120Progressive neurologic deterioration (HP:0002344)1.93253503
121Renal Fanconi syndrome (HP:0001994)1.92660442
122Petechiae (HP:0000967)1.92389179
123Reduced antithrombin III activity (HP:0001976)1.92025811
124Hepatocellular necrosis (HP:0001404)1.88258805
125Methylmalonic acidemia (HP:0002912)1.87326435
126Elevated alkaline phosphatase (HP:0003155)1.86821384
127Neurofibrillary tangles (HP:0002185)1.86619790
128Abnormal platelet volume (HP:0011876)1.86519862
129Abnormality of glycolysis (HP:0004366)1.86366953
130Increased serum pyruvate (HP:0003542)1.86366953
131Elevated hepatic transaminases (HP:0002910)1.85292716
132Cholelithiasis (HP:0001081)1.84332015
133Abnormality of alkaline phosphatase activity (HP:0004379)1.83861150
134Abnormal platelet function (HP:0011869)1.83821511
135Impaired platelet aggregation (HP:0003540)1.83821511
136Amyloidosis (HP:0011034)1.82517429
137Abnormality of transition element cation homeostasis (HP:0011030)1.82416235
138Hyperphosphaturia (HP:0003109)1.82321753
139Abnormal gallbladder physiology (HP:0012438)1.81170789
140Cholecystitis (HP:0001082)1.81170789
141Skin nodule (HP:0200036)1.80799897
142Increased purine levels (HP:0004368)1.80765643
143Hyperuricemia (HP:0002149)1.80765643
144Enlarged kidneys (HP:0000105)1.79942172
145Thrombophlebitis (HP:0004418)1.77952813
146Abnormal atrioventricular conduction (HP:0005150)1.77339947
147Decreased subcutaneous fat (HP:0001002)1.77026672
148Ileus (HP:0002595)1.76919338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.92979345
2INSRR4.23045545
3MAPK153.74219333
4MYLK3.55979999
5STK163.13344214
6STK393.12792147
7ERN13.12262187
8MAPKAPK32.98309136
9EPHB12.91981971
10ACVR1B2.70257984
11TAOK32.58576870
12FLT32.45174802
13WNK42.35323195
14TESK12.23528814
15OXSR12.15768846
16TRIB32.15060507
17PASK2.10396722
18TESK22.05597925
19PDK22.05006729
20EIF2AK32.03776970
21PBK2.02130309
22SCYL21.98182537
23PIK3CG1.97302684
24MET1.90020082
25OBSCN1.79991420
26RIPK11.69059126
27FGFR41.63408105
28SIK11.63298606
29TIE11.58472760
30TTN1.57966962
31MAPKAPK51.57575314
32LIMK11.53763149
33TGFBR21.53223096
34MAP3K31.45654822
35TAOK21.43293701
36CDK191.41876048
37CSNK1G11.34971378
38CSNK1G31.34677588
39EIF2AK11.24904815
40TLK11.23741554
41BCR1.19557884
42CSNK1A1L1.17486154
43HIPK21.16369024
44PIK3CA1.14307216
45ERBB41.09258768
46IKBKB1.08632408
47WNK31.06559657
48IRAK31.04110131
49PINK11.03226406
50LMTK21.00153014
51NME20.96362863
52DYRK1B0.96007289
53DDR20.95422385
54MAP3K140.95000959
55NLK0.92371874
56KDR0.91923775
57IRAK10.89729290
58UHMK10.88864860
59GRK70.87870340
60TEC0.87667664
61VRK10.86611028
62CAMK2G0.86241250
63MST40.85105472
64GRK60.85096809
65PTK60.85053319
66MAP2K20.84972018
67TRPM70.84262761
68ARAF0.83402842
69GRK10.81464585
70TNK20.80744535
71FER0.80199074
72BUB10.79170164
73GSK3A0.77594057
74ILK0.76606757
75CSNK1G20.76278405
76BTK0.75981223
77MAPK110.73224884
78ADRBK20.71256634
79DYRK30.71052388
80FGFR20.70946136
81DAPK30.70763094
82MAP3K60.69648472
83ABL20.69425207
84NTRK10.67588107
85CAMK2D0.66453217
86BLK0.66258289
87ZAP700.65247173
88CAMKK20.65183859
89ITK0.64798086
90TXK0.63864156
91PHKG10.63417438
92PHKG20.63417438
93CAMK2B0.62678855
94MAP2K10.61890297
95BRSK20.61390537
96IRAK20.61137441
97PKN10.61096097
98MUSK0.60950744
99TNIK0.59775789
100NEK90.59109904
101PAK40.56694294
102JAK20.53588049
103IGF1R0.51448683
104MST1R0.50318738
105RPS6KA50.49458367
106MAP3K120.48844120
107PRKG20.48626261
108LATS10.47786777
109AKT30.46174040
110DAPK10.45754371
111EPHA30.45251037
112CHUK0.44404399
113PRKD20.43793242
114CDC42BPA0.43685862
115WNK10.42971494
116KIT0.42943523
117PRKCQ0.42679693
118MAP3K50.42562326
119EPHA20.42003648
120JAK10.41823040
121PAK20.41767799
122SGK2230.41337932
123SGK4940.41337932
124ADRBK10.40565647
125MAPK120.40557043
126RPS6KB20.39616752
127MAP2K60.39332229
128TBK10.39291742
129TAOK10.38283468
130MAP2K30.37300328
131BMX0.36981178
132PRKACG0.36459428
133SMG10.35736964
134PDK10.35037032
135VRK20.34888378
136DYRK20.34558093
137FRK0.34482874
138AKT20.33797205
139STK380.33740220
140PIM20.32464720
141TYK20.31716898
142JAK30.31699234
143CSK0.30967305
144PRKD10.30857795
145PRKAA10.30450471
146PRKAA20.30445028
147NEK60.30353270
148MAP3K10.29753200
149PDPK10.28804406
150IRAK40.27738330
151CSNK1A10.27546461
152BRAF0.26518477
153PTK20.25154467
154BMPR20.24785233
155MAPK40.22426483
156MAP3K110.22223980
157NUAK10.21824670
158PRKACA0.21459906
159CSF1R0.21321201

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.50189714
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.83093496
3Nitrogen metabolism_Homo sapiens_hsa009102.79827433
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73824311
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71053534
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.63682971
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.57519578
8Sulfur metabolism_Homo sapiens_hsa009202.49119419
9Fatty acid elongation_Homo sapiens_hsa000622.45685842
10Tryptophan metabolism_Homo sapiens_hsa003802.36066853
11Folate biosynthesis_Homo sapiens_hsa007902.30091226
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28466964
13Histidine metabolism_Homo sapiens_hsa003402.27640479
14Fatty acid degradation_Homo sapiens_hsa000712.24754417
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18473510
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14300431
17Peroxisome_Homo sapiens_hsa041462.13554759
18Butanoate metabolism_Homo sapiens_hsa006502.13094530
19Protein export_Homo sapiens_hsa030602.06705746
20Arginine biosynthesis_Homo sapiens_hsa002201.98838689
21Propanoate metabolism_Homo sapiens_hsa006401.98810564
22Steroid biosynthesis_Homo sapiens_hsa001001.93266612
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91215967
24Selenocompound metabolism_Homo sapiens_hsa004501.86906390
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83053436
26Complement and coagulation cascades_Homo sapiens_hsa046101.82611354
27Chemical carcinogenesis_Homo sapiens_hsa052041.77732586
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74795385
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72803342
30Fatty acid metabolism_Homo sapiens_hsa012121.71211988
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.69250307
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.67418920
33beta-Alanine metabolism_Homo sapiens_hsa004101.56531727
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48409394
35Retinol metabolism_Homo sapiens_hsa008301.48264203
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42386432
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41359278
38Caffeine metabolism_Homo sapiens_hsa002321.32880293
39Vitamin B6 metabolism_Homo sapiens_hsa007501.32783157
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31221558
41Arginine and proline metabolism_Homo sapiens_hsa003301.29086289
42Tyrosine metabolism_Homo sapiens_hsa003501.28168025
43Pyruvate metabolism_Homo sapiens_hsa006201.28105668
44PPAR signaling pathway_Homo sapiens_hsa033201.26942361
45Phenylalanine metabolism_Homo sapiens_hsa003601.24499807
46Starch and sucrose metabolism_Homo sapiens_hsa005001.21405516
47* Cysteine and methionine metabolism_Homo sapiens_hsa002701.19416165
48ABC transporters_Homo sapiens_hsa020101.16109195
49Sulfur relay system_Homo sapiens_hsa041221.08998199
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07283285
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05656678
52Glutathione metabolism_Homo sapiens_hsa004801.04563614
53Biosynthesis of amino acids_Homo sapiens_hsa012301.01370746
54Fat digestion and absorption_Homo sapiens_hsa049751.01317555
55Carbon metabolism_Homo sapiens_hsa012000.98647095
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96037515
57Bile secretion_Homo sapiens_hsa049760.93513514
58Vitamin digestion and absorption_Homo sapiens_hsa049770.91602520
59Staphylococcus aureus infection_Homo sapiens_hsa051500.87529245
60One carbon pool by folate_Homo sapiens_hsa006700.82824330
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.80125026
62Pentose phosphate pathway_Homo sapiens_hsa000300.78007901
63* Metabolic pathways_Homo sapiens_hsa011000.72656291
64Linoleic acid metabolism_Homo sapiens_hsa005910.72271546
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68476944
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67921249
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67114962
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65455566
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56025277
70Regulation of autophagy_Homo sapiens_hsa041400.51516327
71Glycerolipid metabolism_Homo sapiens_hsa005610.51195091
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46488157
73Lysine degradation_Homo sapiens_hsa003100.45872534
74Pertussis_Homo sapiens_hsa051330.45367913
75Ether lipid metabolism_Homo sapiens_hsa005650.40255433
76Other glycan degradation_Homo sapiens_hsa005110.39593727
77Lysosome_Homo sapiens_hsa041420.38446420
78Mineral absorption_Homo sapiens_hsa049780.37324550
79Galactose metabolism_Homo sapiens_hsa000520.35989312
80Oxidative phosphorylation_Homo sapiens_hsa001900.33494216
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32269008
82Fructose and mannose metabolism_Homo sapiens_hsa000510.29442713
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27839240
84Pyrimidine metabolism_Homo sapiens_hsa002400.26833895
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26468853
86Arachidonic acid metabolism_Homo sapiens_hsa005900.26323232
87N-Glycan biosynthesis_Homo sapiens_hsa005100.24233393
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.23552394
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21884019
90Proteasome_Homo sapiens_hsa030500.20825097
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.20319863
92Prion diseases_Homo sapiens_hsa050200.19688618
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19574246
94Parkinsons disease_Homo sapiens_hsa050120.17787831
95Sphingolipid metabolism_Homo sapiens_hsa006000.15073155
96Systemic lupus erythematosus_Homo sapiens_hsa053220.11754371
97RNA polymerase_Homo sapiens_hsa030200.09734072
98Fatty acid biosynthesis_Homo sapiens_hsa000610.06394127
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.05409860
100Insulin resistance_Homo sapiens_hsa049310.04972209
101Purine metabolism_Homo sapiens_hsa002300.04298367
102Alzheimers disease_Homo sapiens_hsa050100.03033228
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.01818209
104Hepatitis C_Homo sapiens_hsa05160-0.1182576
105Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1040232
106Amoebiasis_Homo sapiens_hsa05146-0.0699433
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0663968
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0550500
109AMPK signaling pathway_Homo sapiens_hsa04152-0.0451781
110Renin-angiotensin system_Homo sapiens_hsa04614-0.0404119
111Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0351765
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0337032
113Glucagon signaling pathway_Homo sapiens_hsa04922-0.0335919
114Platelet activation_Homo sapiens_hsa04611-0.0205637
115Asthma_Homo sapiens_hsa05310-0.0052498

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