ADIG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 [PubMed 15567149]; Hong et al., 2005 [PubMed 16132694]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)9.95900346
2low-density lipoprotein particle clearance (GO:0034383)9.37863950
3triglyceride catabolic process (GO:0019433)8.26354758
4acylglycerol catabolic process (GO:0046464)7.42120186
5neutral lipid catabolic process (GO:0046461)7.42120186
6biotin metabolic process (GO:0006768)7.38362579
7valine metabolic process (GO:0006573)7.33288080
8* brown fat cell differentiation (GO:0050873)7.10476473
9fatty acid transmembrane transport (GO:1902001)6.50996667
10triglyceride biosynthetic process (GO:0019432)6.37557484
11* white fat cell differentiation (GO:0050872)6.35643691
12carnitine shuttle (GO:0006853)6.23190699
13lipid particle organization (GO:0034389)6.22770606
14acylglycerol biosynthetic process (GO:0046463)6.11860384
15neutral lipid biosynthetic process (GO:0046460)6.11860384
16positive regulation of fatty acid oxidation (GO:0046321)5.87654368
17fatty acid beta-oxidation (GO:0006635)5.84185647
18regulation of cholesterol storage (GO:0010885)5.76737958
19negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.60924910
20glycerolipid catabolic process (GO:0046503)5.57270670
21positive regulation of fatty acid beta-oxidation (GO:0032000)5.56405896
22thioester biosynthetic process (GO:0035384)5.49688315
23acyl-CoA biosynthetic process (GO:0071616)5.49688315
24fatty-acyl-CoA biosynthetic process (GO:0046949)5.49541527
25lipid storage (GO:0019915)5.40739765
26branched-chain amino acid catabolic process (GO:0009083)5.34317615
27long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.30018008
28branched-chain amino acid metabolic process (GO:0009081)5.25630977
29long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.18909097
30fatty-acyl-CoA metabolic process (GO:0035337)5.18637976
31carnitine transmembrane transport (GO:1902603)5.16007935
32fatty acid oxidation (GO:0019395)5.08469297
33regulation of fatty acid oxidation (GO:0046320)5.08076493
34lipid oxidation (GO:0034440)4.98894999
35fatty acid catabolic process (GO:0009062)4.96582408
36amino-acid betaine transport (GO:0015838)4.76637869
37carnitine transport (GO:0015879)4.76637869
38coenzyme A biosynthetic process (GO:0015937)4.71913263
39triglyceride metabolic process (GO:0006641)4.71113532
40tricarboxylic acid cycle (GO:0006099)4.54045647
41acetyl-CoA metabolic process (GO:0006084)4.52475093
42acylglycerol metabolic process (GO:0006639)4.45644383
43NADH metabolic process (GO:0006734)4.45373025
44neutral lipid metabolic process (GO:0006638)4.39375592
45cellular response to lithium ion (GO:0071285)4.30557075
46regulation of fatty acid beta-oxidation (GO:0031998)4.28623733
47negative regulation of lipid storage (GO:0010888)4.20923333
48tricarboxylic acid metabolic process (GO:0072350)4.18188245
49regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.17701086
50positive regulation of fatty acid metabolic process (GO:0045923)4.15071233
51positive regulation of lipid storage (GO:0010884)4.14809952
52positive regulation of lipid catabolic process (GO:0050996)4.08950828
53alpha-linolenic acid metabolic process (GO:0036109)4.08757406
54NADPH regeneration (GO:0006740)4.07900562
55pentose-phosphate shunt (GO:0006098)4.06968852
56negative regulation of protein autophosphorylation (GO:0031953)4.02722786
57regulation of triglyceride catabolic process (GO:0010896)3.99984271
58response to dietary excess (GO:0002021)3.96973754
59regulation of macrophage derived foam cell differentiation (GO:0010743)3.93507025
60regulation of cAMP-dependent protein kinase activity (GO:2000479)3.91302989
61protein heterotrimerization (GO:0070208)3.90837837
62fatty acid homeostasis (GO:0055089)3.87715179
63negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.82498686
64plasma lipoprotein particle clearance (GO:0034381)3.82161548
65negative regulation of granulocyte differentiation (GO:0030853)3.81189483
66glycerol metabolic process (GO:0006071)3.78384964
67intracellular lipid transport (GO:0032365)3.78119233
68regulation of acyl-CoA biosynthetic process (GO:0050812)3.76451247
69monocarboxylic acid catabolic process (GO:0072329)3.73330641
70CDP-diacylglycerol biosynthetic process (GO:0016024)3.69688981
71coenzyme A metabolic process (GO:0015936)3.69401927
72regulation of lipid storage (GO:0010883)3.64265444
73succinate metabolic process (GO:0006105)3.63241838
74regulation of glycogen (starch) synthase activity (GO:2000465)3.63078758
75long-chain fatty acid transport (GO:0015909)3.59957880
76regulation of triglyceride metabolic process (GO:0090207)3.59069927
77regulation of triglyceride biosynthetic process (GO:0010866)3.59037907
78positive regulation of glomerulus development (GO:0090193)3.56967820
79quaternary ammonium group transport (GO:0015697)3.56364814
80thioester metabolic process (GO:0035383)3.52755151
81acyl-CoA metabolic process (GO:0006637)3.52755151
82diacylglycerol metabolic process (GO:0046339)3.50144299
83positive regulation of glucose import (GO:0046326)3.49189678
84cellular lipid catabolic process (GO:0044242)3.48793832
85regulation of coenzyme metabolic process (GO:0051196)3.48478827
86regulation of cofactor metabolic process (GO:0051193)3.48478827
87negative regulation of phagocytosis (GO:0050765)3.46559326
88fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.46015392
89positive regulation of cellular response to insulin stimulus (GO:1900078)3.44838399
90regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.41021244
91negative regulation of DNA biosynthetic process (GO:2000279)3.39293821
92alditol metabolic process (GO:0019400)3.38056985
93positive regulation of triglyceride metabolic process (GO:0090208)3.37303383
94oxaloacetate metabolic process (GO:0006107)3.34858523
95phosphatidic acid metabolic process (GO:0046473)3.34049544
96phosphatidic acid biosynthetic process (GO:0006654)3.34049544
97cellular response to epinephrine stimulus (GO:0071872)3.33801665
98complement activation, alternative pathway (GO:0006957)3.30709627
99ovulation from ovarian follicle (GO:0001542)3.29008419
100negative regulation of macrophage differentiation (GO:0045650)3.28714882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse7.21356487
2CLOCK_20551151_ChIP-Seq_293T_Human4.32924548
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.04337989
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.90508730
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.86728637
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.61853448
7PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.55402342
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.51110856
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14005475
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.10510868
11PPARG_20887899_ChIP-Seq_3T3-L1_Mouse2.05807522
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse16.2420175
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.97218286
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90421740
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89141818
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.87572503
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76898993
18ZNF263_19887448_ChIP-Seq_K562_Human1.64347503
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64132042
20PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60165321
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45508683
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.44406894
23PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44280439
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40163787
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31388017
26TBX20_22328084_ChIP-Seq_HEART_Mouse1.28584191
27TBX20_22080862_ChIP-Seq_HEART_Mouse1.28584191
28GATA1_22025678_ChIP-Seq_K562_Human1.20548100
29* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13488343
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08019358
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05192342
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.04665214
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04146751
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00048103
35ESR2_21235772_ChIP-Seq_MCF-7_Human0.95410990
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94677728
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93652758
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93282825
39VDR_24787735_ChIP-Seq_THP-1_Human0.92799482
40ESR1_20079471_ChIP-ChIP_T-47D_Human0.91789873
41SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91696525
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90829971
43ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89927642
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89406341
45SALL1_21062744_ChIP-ChIP_HESCs_Human0.89276587
46CJUN_26792858_Chip-Seq_BT549_Human0.89164699
47CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87318716
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86325388
49P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86240231
50EP300_21415370_ChIP-Seq_HL-1_Mouse0.80970162
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80801957
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76427586
53P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75365413
54RXR_22108803_ChIP-Seq_LS180_Human0.75010195
55GATA2_21666600_ChIP-Seq_HMVEC_Human0.74246806
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73804924
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.73207987
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.70564340
59FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69080058
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.68778289
61CTNNB1_20460455_ChIP-Seq_HCT116_Human0.68521324
62RACK7_27058665_Chip-Seq_MCF-7_Human0.67418400
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67382920
64BCAT_22108803_ChIP-Seq_LS180_Human0.66230160
65LXR_22292898_ChIP-Seq_THP-1_Human0.65155497
66RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64919247
67GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.63677103
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63030437
69TP63_22573176_ChIP-Seq_HFKS_Human0.62217418
70GATA3_24758297_ChIP-Seq_MCF-7_Human0.62182654
71GATA1_19941826_ChIP-Seq_K562_Human0.60918965
72FOXA2_19822575_ChIP-Seq_HepG2_Human0.60883337
73ESR1_21235772_ChIP-Seq_MCF-7_Human0.60361085
74CEBPB_22108803_ChIP-Seq_LS180_Human0.60167009
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.60143558
76RUNX1_27514584_Chip-Seq_MCF-7_Human0.59673150
77SOX2_27498859_Chip-Seq_STOMACH_Mouse0.59673024
78KLF4_19829295_ChIP-Seq_ESCs_Human0.59340318
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58923714
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.58916820
81P300_27268052_Chip-Seq_Bcells_Human0.57793764
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.57470328
83NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.56974259
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.56966427
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.56258129
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.55892646
87ATF3_27146783_Chip-Seq_COLON_Human0.55152541
88TET1_21451524_ChIP-Seq_MESCs_Mouse0.54500389
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.53607078
90* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.53182782
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.53110418
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.52076654
93SOX2_20726797_ChIP-Seq_SW620_Human0.51499881
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.51203544
95NRF2_20460467_ChIP-Seq_MEFs_Mouse0.51203544
96KDM2B_26808549_Chip-Seq_K562_Human0.51129870
97ERG_20517297_ChIP-Seq_VCAP_Human0.49254157
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.48513970
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.48324943
100FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.48134357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose8.63293052
2MP0005666_abnormal_adipose_tissue5.97421127
3MP0004185_abnormal_adipocyte_glucose5.53849292
4MP0004130_abnormal_muscle_cell5.38758862
5MP0005375_adipose_tissue_phenotype4.25585389
6MP0002971_abnormal_brown_adipose3.63225265
7MP0008438_abnormal_cutaneous_collagen3.62749371
8MP0000013_abnormal_adipose_tissue3.20781749
9MP0000003_abnormal_adipose_tissue2.89404018
10MP0002837_dystrophic_cardiac_calcinosis2.88937963
11MP0009115_abnormal_fat_cell2.82092447
12MP0010329_abnormal_lipoprotein_level2.80896845
13MP0002876_abnormal_thyroid_physiology2.68606839
14MP0005334_abnormal_fat_pad2.56873686
15MP0005275_abnormal_skin_tensile2.43466435
16MP0002970_abnormal_white_adipose2.39516460
17MP0005535_abnormal_body_temperature2.17250531
18MP0002118_abnormal_lipid_homeostasis2.10621929
19MP0001661_extended_life_span2.10089422
20MP0003191_abnormal_cellular_cholesterol1.91805145
21MP0003959_abnormal_lean_body1.80524206
22MP0003724_increased_susceptibility_to1.66861088
23MP0003705_abnormal_hypodermis_morpholog1.64807526
24MP0001881_abnormal_mammary_gland1.61029201
25MP0005448_abnormal_energy_balance1.60749609
26MP0003186_abnormal_redox_activity1.59010366
27MP0003646_muscle_fatigue1.53325107
28MP0005452_abnormal_adipose_tissue1.50403845
29MP0004272_abnormal_basement_membrane1.47999341
30MP0005365_abnormal_bile_salt1.40573265
31MP0000609_abnormal_liver_physiology1.38703472
32MP0002078_abnormal_glucose_homeostasis1.36828963
33MP0006138_congestive_heart_failure1.28986897
34MP0006036_abnormal_mitochondrial_physio1.26925632
35MP0003828_pulmonary_edema1.26880963
36MP0002796_impaired_skin_barrier1.25861496
37MP0003690_abnormal_glial_cell1.22524268
38MP0008775_abnormal_heart_ventricle1.16883578
39MP0002060_abnormal_skin_morphology1.03906758
40MP0005584_abnormal_enzyme/coenzyme_acti1.03847668
41MP0000750_abnormal_muscle_regeneration1.01131862
42MP0000343_altered_response_to1.00667502
43MP0009780_abnormal_chondrocyte_physiolo0.93409818
44MP0001501_abnormal_sleep_pattern0.92662952
45MP0001544_abnormal_cardiovascular_syste0.92194437
46MP0005385_cardiovascular_system_phenoty0.92194437
47MP0003221_abnormal_cardiomyocyte_apopto0.92095535
48MP0003011_delayed_dark_adaptation0.91656088
49MP0002166_altered_tumor_susceptibility0.91026533
50MP0001727_abnormal_embryo_implantation0.88882382
51MP0003045_fibrosis0.88636107
52MP0002909_abnormal_adrenal_gland0.86336934
53MP0005620_abnormal_muscle_contractility0.85667103
54MP0004087_abnormal_muscle_fiber0.85350588
55MP0008961_abnormal_basal_metabolism0.84898370
56MP0002254_reproductive_system_inflammat0.84001821
57MP0003566_abnormal_cell_adhesion0.83139482
58MP0005332_abnormal_amino_acid0.82288637
59MP0005164_abnormal_response_to0.80714827
60MP0001764_abnormal_homeostasis0.79611422
61MP0003948_abnormal_gas_homeostasis0.78680805
62MP0003953_abnormal_hormone_level0.78434631
63MP0002332_abnormal_exercise_endurance0.78415557
64MP0000759_abnormal_skeletal_muscle0.78391338
65MP0000751_myopathy0.76178836
66MP0005319_abnormal_enzyme/_coenzyme0.75700204
67MP0002139_abnormal_hepatobiliary_system0.73161493
68MP0005330_cardiomyopathy0.70683750
69MP0004147_increased_porphyrin_level0.69902245
70MP0005645_abnormal_hypothalamus_physiol0.67518868
71MP0002006_tumorigenesis0.66317106
72MP0001756_abnormal_urination0.66100863
73MP0009643_abnormal_urine_homeostasis0.64530736
74MP0002168_other_aberrant_phenotype0.64416734
75MP0001879_abnormal_lymphatic_vessel0.63879155
76MP0003950_abnormal_plasma_membrane0.60401701
77MP0002972_abnormal_cardiac_muscle0.60273828
78MP0002638_abnormal_pupillary_reflex0.59168134
79MP0005410_abnormal_fertilization0.56136852
80MP0005076_abnormal_cell_differentiation0.52784462
81MP0000230_abnormal_systemic_arterial0.52031033
82MP0010630_abnormal_cardiac_muscle0.48958660
83MP0001853_heart_inflammation0.48457842
84MP0002295_abnormal_pulmonary_circulatio0.48353658
85MP0001177_atelectasis0.47956587
86MP0009672_abnormal_birth_weight0.47891077
87MP0005647_abnormal_sex_gland0.47845745
88MP0004215_abnormal_myocardial_fiber0.47250347
89MP0002009_preneoplasia0.47057582
90MP0009763_increased_sensitivity_to0.46757257
91MP0000249_abnormal_blood_vessel0.46604778
92MP0005501_abnormal_skin_physiology0.46235246
93MP0002108_abnormal_muscle_morphology0.45503174
94MP0002133_abnormal_respiratory_system0.44678166
95MP0005388_respiratory_system_phenotype0.44678166
96MP0005058_abnormal_lysosome_morphology0.43352576
97MP0005379_endocrine/exocrine_gland_phen0.43210019
98MP0003448_altered_tumor_morphology0.40576609
99MP0005376_homeostasis/metabolism_phenot0.40278270
100MP0001533_abnormal_skeleton_physiology0.39878955

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)8.24532740
2Acanthosis nigricans (HP:0000956)6.98043470
3Hyperglycinuria (HP:0003108)6.59305609
4Hypertriglyceridemia (HP:0002155)6.30014858
5Abnormality of glycine metabolism (HP:0010895)5.35790762
6Abnormality of serine family amino acid metabolism (HP:0010894)5.35790762
7Insulin-resistant diabetes mellitus (HP:0000831)5.00027017
8Myoglobinuria (HP:0002913)4.88612568
9Abnormality of fatty-acid metabolism (HP:0004359)4.68846261
10Hypoglycemic coma (HP:0001325)4.45886013
11Increased muscle lipid content (HP:0009058)4.37094957
12Difficulty running (HP:0009046)4.21406341
13Complement deficiency (HP:0004431)4.04980260
14Long foot (HP:0001833)4.02579976
15Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.02417884
16Rhabdomyolysis (HP:0003201)3.96778199
17Abnormality of proline metabolism (HP:0010907)3.80944615
18Hydroxyprolinuria (HP:0003080)3.80944615
19Abnormality of dicarboxylic acid metabolism (HP:0010995)3.78632504
20Dicarboxylic aciduria (HP:0003215)3.78632504
21Ketoacidosis (HP:0001993)3.73754788
22Growth hormone excess (HP:0000845)3.66689314
23Insulin resistance (HP:0000855)3.59424288
24Nausea (HP:0002018)3.57944679
25Ketosis (HP:0001946)3.57659857
26Reduced subcutaneous adipose tissue (HP:0003758)3.46834476
27Bone cyst (HP:0012062)3.43041331
28Hyperglycinemia (HP:0002154)3.30235348
29Multiple enchondromatosis (HP:0005701)3.28293462
30Hypoalphalipoproteinemia (HP:0003233)3.24753470
31Hyperammonemia (HP:0001987)3.12695407
32Subcapsular cataract (HP:0000523)2.96406112
33Pigmentary retinal degeneration (HP:0001146)2.95529229
34Epidermoid cyst (HP:0200040)2.93072509
35Abnormality of complement system (HP:0005339)2.89499960
36Increased connective tissue (HP:0009025)2.88952588
37Hepatic necrosis (HP:0002605)2.88377652
38Large hands (HP:0001176)2.85855249
39Generalized aminoaciduria (HP:0002909)2.83889178
40Hyperthyroidism (HP:0000836)2.72378558
41Hemorrhage of the eye (HP:0011885)2.71838674
42Pancreatitis (HP:0001733)2.68050714
43Hyperpituitarism (HP:0010514)2.67631951
44Myocardial infarction (HP:0001658)2.59918555
45Muscle stiffness (HP:0003552)2.55284114
46Abnormal cartilage morphology (HP:0002763)2.51785721
47Toxemia of pregnancy (HP:0100603)2.50503238
48Prenatal maternal abnormality (HP:0002686)2.49906982
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46221699
50Abnormality of alanine metabolism (HP:0010916)2.46221699
51Hyperalaninemia (HP:0003348)2.46221699
52Thyroid-stimulating hormone excess (HP:0002925)2.41617488
53Ankle contracture (HP:0006466)2.34006761
54Abnormality of glycolysis (HP:0004366)2.32954374
55Increased serum pyruvate (HP:0003542)2.32954374
56Facial diplegia (HP:0001349)2.29214525
57Brushfield spots (HP:0001088)2.26207486
58Decreased subcutaneous fat (HP:0001002)2.25133232
59Tetraparesis (HP:0002273)2.22375384
60Abnormal hemoglobin (HP:0011902)2.21891995
61Spinal rigidity (HP:0003306)2.20924721
62Hyperlipoproteinemia (HP:0010980)2.20178441
63Renal cortical cysts (HP:0000803)2.20161675
64Increased variability in muscle fiber diameter (HP:0003557)2.20065214
65Accelerated skeletal maturation (HP:0005616)2.17908181
66Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16368365
67Hyperglycemia (HP:0003074)2.14977154
68Cerebral aneurysm (HP:0004944)2.13563417
69Limb hypertonia (HP:0002509)2.13280873
70Polygenic inheritance (HP:0010982)2.13238930
71Broad metatarsal (HP:0001783)2.12599872
72Lethargy (HP:0001254)2.11997207
73Lipoatrophy (HP:0100578)2.11742563
74Hypercortisolism (HP:0001578)2.08928897
75Methylmalonic aciduria (HP:0012120)2.07918021
76Type 1 muscle fiber predominance (HP:0003803)2.06192752
77Prominent supraorbital ridges (HP:0000336)2.04546720
78Autoimmune thrombocytopenia (HP:0001973)2.04437227
79Skin nodule (HP:0200036)2.03915219
80Xanthomatosis (HP:0000991)2.03747494
81Conjunctival hamartoma (HP:0100780)2.02859837
82Turricephaly (HP:0000262)2.00815823
83Cerebral edema (HP:0002181)1.97208086
84Abnormality of serum amino acid levels (HP:0003112)1.96116771
85Exercise-induced myalgia (HP:0003738)1.96086784
86Hypercholesterolemia (HP:0003124)1.92986636
87Hyporeflexia of lower limbs (HP:0002600)1.92837039
88Vomiting (HP:0002013)1.91717680
89Abnormality of subcutaneous fat tissue (HP:0001001)1.90175785
90Neonatal hypoglycemia (HP:0001998)1.90034407
91Tachypnea (HP:0002789)1.89611105
92Polyphagia (HP:0002591)1.88098233
93Follicular hyperkeratosis (HP:0007502)1.86585869
94Polar cataract (HP:0010696)1.85488602
95Proximal tubulopathy (HP:0000114)1.85484088
96Clitoromegaly (HP:0000057)1.85358255
97Gonadotropin excess (HP:0000837)1.84216144
98Muscle fiber splitting (HP:0003555)1.83626666
99Acute encephalopathy (HP:0006846)1.81308066
100Abnormal eating behavior (HP:0100738)1.78867637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D6.35589168
2TRIB35.27849232
3BCKDK5.01283985
4CAMK1G4.60472305
5PDK34.39610705
6PDK44.39610705
7SIK14.06095516
8PDK22.68744369
9ERN12.18457783
10RIPK12.14975274
11LMTK22.08604180
12PRKAA21.90445135
13MST1R1.88187215
14CDK91.84415834
15PRKD31.47012674
16EPHB21.39882304
17INSRR1.36089942
18CDK61.31067489
19PDGFRA1.24369661
20MAP3K61.23547968
21MAP2K11.22266189
22DDR21.17623122
23FGFR31.13535210
24FGFR21.08301409
25FRK1.05894042
26PKN21.03869770
27TIE10.99674426
28ICK0.99616358
29PRKAA10.97627609
30PDPK10.93199013
31TGFBR20.90801164
32PIK3CA0.87390501
33LATS10.86175671
34IRAK30.86140584
35PHKG10.85903693
36PHKG20.85903693
37PINK10.77734784
38LATS20.77458393
39PDK10.76782104
40JAK10.76625732
41MET0.75569743
42FGFR40.65488578
43GSK3A0.64511665
44ILK0.64122925
45FER0.63883043
46JAK20.63360292
47BMX0.63117753
48MTOR0.60173215
49PRKACG0.59716861
50PTK2B0.58032334
51TTN0.56981601
52PRKCH0.56337344
53MYLK0.55736021
54MAPK110.55216542
55CAMK10.54719595
56TNK20.54641153
57PDGFRB0.53852477
58NEK90.53106797
59CDK40.52370291
60IGF1R0.51875619
61RET0.48451702
62FLT30.48280507
63PRKD10.48194159
64PAK20.43161819
65PRKD20.42862265
66MAP2K30.42844825
67INSR0.42320401
68IRAK10.40115582
69CAMKK20.38119575
70EIF2AK20.37685175
71FGFR10.36261691
72RPS6KB10.35859492
73PRKG20.35517837
74TYRO30.35122945
75STK30.34949313
76JAK30.34211561
77MAP3K30.33119077
78STK380.28198843
79CSK0.27885945
80MAPK120.27011048
81SRC0.26283569
82TESK10.26243302
83IRAK20.26041624
84ABL20.25482440
85DAPK20.25299830
86LRRK20.22505563
87MAPKAPK30.21053766
88MARK20.20289816
89EPHB10.20289500
90MAP2K40.18489036
91PRKCZ0.18275408
92EEF2K0.18205442
93AKT10.18004250
94STK38L0.17774685
95MAPK40.17535898
96TRPM70.16670573
97KSR20.16375879
98STK110.15474542
99CSF1R0.14224799
100ABL10.13702981

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006405.14022976
2Fatty acid biosynthesis_Homo sapiens_hsa000614.96858718
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.42710939
4PPAR signaling pathway_Homo sapiens_hsa033204.24696878
5Fatty acid metabolism_Homo sapiens_hsa012124.02293151
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.80028258
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.73330464
8Fatty acid degradation_Homo sapiens_hsa000713.36751872
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.06435873
10Glycerolipid metabolism_Homo sapiens_hsa005612.80667075
11Pyruvate metabolism_Homo sapiens_hsa006202.64013745
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18774862
13Carbon metabolism_Homo sapiens_hsa012002.12010252
14Fatty acid elongation_Homo sapiens_hsa000622.03906226
15beta-Alanine metabolism_Homo sapiens_hsa004102.03116257
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.91569623
17AMPK signaling pathway_Homo sapiens_hsa041521.76472394
18Peroxisome_Homo sapiens_hsa041461.59985955
19Butanoate metabolism_Homo sapiens_hsa006501.58270785
20Fat digestion and absorption_Homo sapiens_hsa049751.56783289
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52920934
22Caffeine metabolism_Homo sapiens_hsa002321.46901391
23Nitrogen metabolism_Homo sapiens_hsa009101.19591349
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08563727
25Insulin resistance_Homo sapiens_hsa049311.08112250
26Insulin signaling pathway_Homo sapiens_hsa049101.05072878
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03757653
28Vitamin B6 metabolism_Homo sapiens_hsa007501.03277788
29Phenylalanine metabolism_Homo sapiens_hsa003600.99852665
30Glucagon signaling pathway_Homo sapiens_hsa049220.98732800
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92252410
32Pentose phosphate pathway_Homo sapiens_hsa000300.87804844
33Tryptophan metabolism_Homo sapiens_hsa003800.87540608
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87342529
35Glycerophospholipid metabolism_Homo sapiens_hsa005640.83314413
36Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82844422
37Tyrosine metabolism_Homo sapiens_hsa003500.82332174
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82163603
39Staphylococcus aureus infection_Homo sapiens_hsa051500.73108634
40Biosynthesis of amino acids_Homo sapiens_hsa012300.71241328
41Renin secretion_Homo sapiens_hsa049240.64021589
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55645754
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53921809
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.51602026
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50129129
46Sulfur metabolism_Homo sapiens_hsa009200.49777985
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46656515
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46126191
49Type II diabetes mellitus_Homo sapiens_hsa049300.45873603
50Starch and sucrose metabolism_Homo sapiens_hsa005000.43459158
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43384825
52Lysine degradation_Homo sapiens_hsa003100.42245873
53ECM-receptor interaction_Homo sapiens_hsa045120.40960950
54ABC transporters_Homo sapiens_hsa020100.39378633
55Glutathione metabolism_Homo sapiens_hsa004800.38879331
56Fructose and mannose metabolism_Homo sapiens_hsa000510.35308294
57Chemical carcinogenesis_Homo sapiens_hsa052040.33290922
58Protein digestion and absorption_Homo sapiens_hsa049740.32228951
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32042467
60HIF-1 signaling pathway_Homo sapiens_hsa040660.31594453
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31024341
62Arginine biosynthesis_Homo sapiens_hsa002200.30500758
63Sulfur relay system_Homo sapiens_hsa041220.29816653
64Parkinsons disease_Homo sapiens_hsa050120.29003791
65Oxidative phosphorylation_Homo sapiens_hsa001900.28849459
66Linoleic acid metabolism_Homo sapiens_hsa005910.28802740
67Metabolic pathways_Homo sapiens_hsa011000.28229440
68Alzheimers disease_Homo sapiens_hsa050100.25465134
69Retinol metabolism_Homo sapiens_hsa008300.24176586
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23522929
71mTOR signaling pathway_Homo sapiens_hsa041500.23430632
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.23102440
73Arachidonic acid metabolism_Homo sapiens_hsa005900.22769907
74Autoimmune thyroid disease_Homo sapiens_hsa053200.19973523
75Acute myeloid leukemia_Homo sapiens_hsa052210.19844287
76Focal adhesion_Homo sapiens_hsa045100.19497608
77Thyroid cancer_Homo sapiens_hsa052160.19015626
78cAMP signaling pathway_Homo sapiens_hsa040240.17009500
79Complement and coagulation cascades_Homo sapiens_hsa046100.16684485
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.16465833
81Huntingtons disease_Homo sapiens_hsa050160.13366213
82Galactose metabolism_Homo sapiens_hsa000520.10743257
83Salivary secretion_Homo sapiens_hsa049700.07507145
84Proteoglycans in cancer_Homo sapiens_hsa052050.05864077
85Small cell lung cancer_Homo sapiens_hsa052220.03743835
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.03292680
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.02243876
88Thyroid hormone synthesis_Homo sapiens_hsa049180.00804780
89Lysosome_Homo sapiens_hsa041420.00336835
90Ovarian steroidogenesis_Homo sapiens_hsa049130.00117767
91Melanoma_Homo sapiens_hsa052180.00045552
92Toxoplasmosis_Homo sapiens_hsa05145-0.0522448
93Sphingolipid signaling pathway_Homo sapiens_hsa04071-0.0411798
94Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0405474
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0333249
96Amoebiasis_Homo sapiens_hsa05146-0.0293364
97FoxO signaling pathway_Homo sapiens_hsa04068-0.0233911
98Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0224385
99Histidine metabolism_Homo sapiens_hsa00340-0.0194490
100PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0043867

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