ADIPOQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)9.66146167
2triglyceride catabolic process (GO:0019433)9.15482232
3white fat cell differentiation (GO:0050872)8.85647508
4acylglycerol catabolic process (GO:0046464)8.22352453
5neutral lipid catabolic process (GO:0046461)8.22352453
6valine metabolic process (GO:0006573)8.05342201
7* brown fat cell differentiation (GO:0050873)7.41499330
8* low-density lipoprotein particle clearance (GO:0034383)7.18080586
9biotin metabolic process (GO:0006768)7.06534731
10lipid particle organization (GO:0034389)6.62751341
11regulation of cholesterol storage (GO:0010885)6.59254680
12triglyceride biosynthetic process (GO:0019432)6.38845360
13positive regulation of fatty acid oxidation (GO:0046321)6.19131540
14glycerolipid catabolic process (GO:0046503)6.15929312
15neutral lipid biosynthetic process (GO:0046460)6.09881475
16acylglycerol biosynthetic process (GO:0046463)6.09881475
17positive regulation of fatty acid beta-oxidation (GO:0032000)6.02752443
18fatty acid transmembrane transport (GO:1902001)5.98566996
19lipid storage (GO:0019915)5.41746982
20branched-chain amino acid metabolic process (GO:0009081)5.36211175
21carnitine shuttle (GO:0006853)5.30883068
22branched-chain amino acid catabolic process (GO:0009083)5.24701271
23response to dietary excess (GO:0002021)5.17092203
24ethanol oxidation (GO:0006069)5.09422041
25triglyceride metabolic process (GO:0006641)4.98760253
26long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.96303268
27fatty-acyl-CoA biosynthetic process (GO:0046949)4.94455745
28polyol transport (GO:0015791)4.90260882
29long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.86297040
30thioester biosynthetic process (GO:0035384)4.85302769
31acyl-CoA biosynthetic process (GO:0071616)4.85302769
32fatty-acyl-CoA metabolic process (GO:0035337)4.84526873
33regulation of fatty acid oxidation (GO:0046320)4.74648354
34acylglycerol metabolic process (GO:0006639)4.70673649
35* fatty acid beta-oxidation (GO:0006635)4.69346726
36coenzyme A biosynthetic process (GO:0015937)4.69344927
37neutral lipid metabolic process (GO:0006638)4.64303105
38regulation of fatty acid beta-oxidation (GO:0031998)4.61820522
39cellular response to lithium ion (GO:0071285)4.54391989
40fatty acid homeostasis (GO:0055089)4.53141678
41positive regulation of cellular response to insulin stimulus (GO:1900078)4.49698941
42response to phenylpropanoid (GO:0080184)4.49539478
43alpha-linolenic acid metabolic process (GO:0036109)4.49301384
44negative regulation of lipid storage (GO:0010888)4.41795383
45positive regulation of lipid catabolic process (GO:0050996)4.33324308
46carnitine transmembrane transport (GO:1902603)4.31378284
47pentose-phosphate shunt (GO:0006098)4.29414690
48* fatty acid oxidation (GO:0019395)4.28776171
49positive regulation of glycolytic process (GO:0045821)4.27749629
50ovulation from ovarian follicle (GO:0001542)4.25782644
51positive regulation of lipid storage (GO:0010884)4.24488015
52NADPH regeneration (GO:0006740)4.23395079
53* lipid oxidation (GO:0034440)4.20390272
54tricarboxylic acid metabolic process (GO:0072350)4.16333237
55primary alcohol metabolic process (GO:0034308)4.15074954
56complement activation, alternative pathway (GO:0006957)4.11592970
57acetyl-CoA metabolic process (GO:0006084)4.07886587
58NADH metabolic process (GO:0006734)4.06568743
59* fatty acid catabolic process (GO:0009062)4.03737391
60regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.02234852
61negative regulation of amino acid transport (GO:0051956)3.99143922
62cGMP-mediated signaling (GO:0019934)3.98605190
63retinol metabolic process (GO:0042572)3.97614707
64amino-acid betaine transport (GO:0015838)3.96215142
65carnitine transport (GO:0015879)3.96215142
66ethanol metabolic process (GO:0006067)3.94170368
67regulation of gonadotropin secretion (GO:0032276)3.91333339
68oxaloacetate metabolic process (GO:0006107)3.88629846
69CDP-diacylglycerol biosynthetic process (GO:0016024)3.86321874
70positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.85807977
71growth hormone receptor signaling pathway (GO:0060396)3.84314733
72positive regulation of insulin receptor signaling pathway (GO:0046628)3.82851333
73diacylglycerol metabolic process (GO:0046339)3.80046560
74regulation of lipid storage (GO:0010883)3.78124536
75glycerol metabolic process (GO:0006071)3.77393243
76regulation of triglyceride catabolic process (GO:0010896)3.77054889
77retina vasculature morphogenesis in camera-type eye (GO:0061299)3.76772704
78protein localization to cell surface (GO:0034394)3.71681524
79L-serine transport (GO:0015825)3.62725788
80regulation of triglyceride biosynthetic process (GO:0010866)3.60643160
81regulation of triglyceride metabolic process (GO:0090207)3.59855002
82negative regulation of lipid catabolic process (GO:0050995)3.59009951
83coenzyme A metabolic process (GO:0015936)3.58386360
84response to hydroperoxide (GO:0033194)3.57993594
85positive regulation of lipoprotein lipase activity (GO:0051006)3.57795701
86positive regulation of triglyceride lipase activity (GO:0061365)3.57795701
87thioester metabolic process (GO:0035383)3.57728067
88acyl-CoA metabolic process (GO:0006637)3.57728067
89* plasma lipoprotein particle clearance (GO:0034381)3.57193737
90phospholipid homeostasis (GO:0055091)3.56588702
91intracellular lipid transport (GO:0032365)3.54631254
92CDP-diacylglycerol metabolic process (GO:0046341)3.46625844
93cellular response to growth hormone stimulus (GO:0071378)3.43485996
94long-chain fatty acid transport (GO:0015909)3.43371663
95glomerular filtration (GO:0003094)3.43082312
96tricarboxylic acid cycle (GO:0006099)3.42933375
97regulation of lipoprotein metabolic process (GO:0050746)3.41844032
98succinate metabolic process (GO:0006105)3.40675639
99* negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.39762906
100endocrine hormone secretion (GO:0060986)3.37909489
101acylglycerol homeostasis (GO:0055090)3.37777936
102triglyceride homeostasis (GO:0070328)3.37777936
103phosphatidic acid metabolic process (GO:0046473)3.37660036
104phosphatidic acid biosynthetic process (GO:0006654)3.37660036
1052-oxoglutarate metabolic process (GO:0006103)3.36029527
106* positive regulation of fatty acid metabolic process (GO:0045923)3.34043154
107barbed-end actin filament capping (GO:0051016)3.33201781
108positive regulation of triglyceride metabolic process (GO:0090208)3.33038728
109alditol metabolic process (GO:0019400)3.32520593
110fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26859346
111triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.26187916
112regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.26097165
113cellular response to vitamin (GO:0071295)3.25806175
114* regulation of macrophage derived foam cell differentiation (GO:0010743)3.23530379
115* fat cell differentiation (GO:0045444)3.20554329
116transcytosis (GO:0045056)3.19310348
117regulation of lipid catabolic process (GO:0050994)3.18057032
118glucose catabolic process (GO:0006007)3.17774037
119regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.16793187
120positive regulation of histone deacetylation (GO:0031065)3.15058496
121lipoprotein transport (GO:0042953)3.14801124
122* cellular lipid catabolic process (GO:0044242)3.14214286
123tyrosine phosphorylation of STAT protein (GO:0007260)3.13879641
124cellular response to leptin stimulus (GO:0044320)3.13046844
125serine transport (GO:0032329)3.12078529
126positive regulation of macrophage cytokine production (GO:0060907)3.11694368
127negative regulation of organic acid transport (GO:0032891)3.10938265
128adaptation of signaling pathway (GO:0023058)3.10464998
129response to lipoprotein particle (GO:0055094)3.10407988
130negative regulation of appetite (GO:0032099)3.09455859
131negative regulation of response to food (GO:0032096)3.09455859
132phagocytosis, recognition (GO:0006910)3.06437717
133response to vitamin E (GO:0033197)3.05319476
134apoptotic cell clearance (GO:0043277)3.02045475
135renal filtration (GO:0097205)3.00257573
136negative regulation of execution phase of apoptosis (GO:1900118)2.95961573
137positive regulation of endothelial cell apoptotic process (GO:2000353)2.93965061
138response to nitrosative stress (GO:0051409)2.91922785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse6.75990397
2CLOCK_20551151_ChIP-Seq_293T_Human4.77289023
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.90471367
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.73648466
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.69731616
6PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.63165549
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.56741897
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.56545582
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.54774746
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.19294840
11* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse2.15051218
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse15.8577760
13RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95677238
14* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.88860362
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.84375372
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82594058
17GATA1_22025678_ChIP-Seq_K562_Human1.79690844
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.71894967
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71612506
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64219962
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61987953
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60697824
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52053426
24ZNF263_19887448_ChIP-Seq_K562_Human1.50196878
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48697127
26EZH2_22144423_ChIP-Seq_EOC_Human1.47936360
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45018668
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.41928351
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33336356
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32718047
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31121833
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30456248
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29227259
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27342657
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.25154472
36TBX20_22080862_ChIP-Seq_HEART_Mouse1.25154472
37CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24049662
38* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23790773
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.23401847
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23030613
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09606169
42SA1_22415368_ChIP-Seq_MEFs_Mouse1.08677272
43PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08674921
44CJUN_26792858_Chip-Seq_BT549_Human1.05732420
45VDR_24787735_ChIP-Seq_THP-1_Human1.05382050
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.04445915
47GBX2_23144817_ChIP-Seq_PC3_Human1.04353691
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02376796
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01142665
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99921710
51ESR1_20079471_ChIP-ChIP_T-47D_Human0.98807087
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98751386
53GATA2_21666600_ChIP-Seq_HMVEC_Human0.98705930
54WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97946681
55* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97326889
56JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97300079
57EP300_21415370_ChIP-Seq_HL-1_Mouse0.96654164
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96476519
59CBP_21632823_ChIP-Seq_H3396_Human0.96087312
60EZH2_27304074_Chip-Seq_ESCs_Mouse0.95269115
61SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95043492
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93630792
63TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93344581
64P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90389937
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88620586
66TP53_20018659_ChIP-ChIP_R1E_Mouse0.88500219
67DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88178601
68SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88016401
69CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87944840
70AHR_22903824_ChIP-Seq_MCF-7_Human0.86006768
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85988614
72NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85468292
73RXR_22108803_ChIP-Seq_LS180_Human0.85256162
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83943271
75NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83390539
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83390539
77SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83197835
78ELK4_26923725_Chip-Seq_MESODERM_Mouse0.82908066
79SALL1_21062744_ChIP-ChIP_HESCs_Human0.82508121
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82392262
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81256443
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81175499
83GATA1_19941826_ChIP-Seq_K562_Human0.79789616
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.78588191
85P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77647832
86FOXA2_19822575_ChIP-Seq_HepG2_Human0.77190176
87* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75179426
88CTCF_27219007_Chip-Seq_Bcells_Human0.74900148
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74743725
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73618608
91RNF2_27304074_Chip-Seq_ESCs_Mouse0.73099012
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.71982609
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71762141
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.71451497
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.69169496
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69046746
97SOX2_20726797_ChIP-Seq_SW620_Human0.69039468
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.68921615
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.68476693
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.68149568
101RNF2_18974828_ChIP-Seq_MESCs_Mouse0.67876114
102EZH2_18974828_ChIP-Seq_MESCs_Mouse0.67876114
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.67598554
104EZH2_27294783_Chip-Seq_ESCs_Mouse0.67089852
105ARNT_22903824_ChIP-Seq_MCF-7_Human0.66131279
106BCAT_22108803_ChIP-Seq_LS180_Human0.65342699
107MYB_21317192_ChIP-Seq_ERMYB_Mouse0.64845316
108GATA3_24758297_ChIP-Seq_MCF-7_Human0.64437710
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64345111
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.63509542
111* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.63385890
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.63074950
113IRF8_22096565_ChIP-ChIP_GC-B_Human0.62896619
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.62700851
115LXR_22292898_ChIP-Seq_THP-1_Human0.62089689
116KLF4_19829295_ChIP-Seq_ESCs_Human0.62029040
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.61875145
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.61683931
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61560067
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.61309151
121GATA2_19941826_ChIP-Seq_K562_Human0.61200762
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.61072528
123GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.60741118
124RACK7_27058665_Chip-Seq_MCF-7_Human0.60275353
125* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.60092297
126ESR1_21235772_ChIP-Seq_MCF-7_Human0.59497674
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.58729911
128IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.57887248
129SOX2_27498859_Chip-Seq_STOMACH_Mouse0.57620721
130* KDM2B_26808549_Chip-Seq_K562_Human0.56975187
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56824663
132ATF3_27146783_Chip-Seq_COLON_Human0.56298722
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.56074810
134RUNX1_27514584_Chip-Seq_MCF-7_Human0.55837378
135JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55689136
136SMAD_19615063_ChIP-ChIP_OVARY_Human0.54155569
137* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.53539842
138GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.53021246
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.52620406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose8.40929985
2MP0005666_abnormal_adipose_tissue5.78179322
3MP0004185_abnormal_adipocyte_glucose5.31391950
4MP0004130_abnormal_muscle_cell5.29734798
5MP0008438_abnormal_cutaneous_collagen4.57892380
6MP0005375_adipose_tissue_phenotype4.31429887
7MP0000013_abnormal_adipose_tissue3.52114610
8MP0002971_abnormal_brown_adipose3.24580487
9MP0002837_dystrophic_cardiac_calcinosis3.18418979
10MP0000003_abnormal_adipose_tissue3.10537354
11MP0005275_abnormal_skin_tensile2.93756215
12MP0002876_abnormal_thyroid_physiology2.91913243
13MP0010329_abnormal_lipoprotein_level2.86424784
14MP0009115_abnormal_fat_cell2.83907045
15MP0005334_abnormal_fat_pad2.61239560
16MP0003191_abnormal_cellular_cholesterol2.38264620
17MP0001661_extended_life_span2.32071825
18MP0002970_abnormal_white_adipose2.25869548
19MP0003011_delayed_dark_adaptation2.18441557
20MP0005503_abnormal_tendon_morphology2.16807872
21MP0003705_abnormal_hypodermis_morpholog2.04627446
22MP0003959_abnormal_lean_body1.92197193
23* MP0002118_abnormal_lipid_homeostasis1.91146525
24MP0005535_abnormal_body_temperature1.90264342
25MP0004272_abnormal_basement_membrane1.89210583
26MP0003868_abnormal_feces_composition1.87725065
27MP0003724_increased_susceptibility_to1.70544836
28MP0003690_abnormal_glial_cell1.49022530
29* MP0005452_abnormal_adipose_tissue1.32514307
30* MP0005448_abnormal_energy_balance1.31225055
31MP0005365_abnormal_bile_salt1.26299027
32* MP0000609_abnormal_liver_physiology1.22228182
33* MP0002078_abnormal_glucose_homeostasis1.20927711
34MP0002060_abnormal_skin_morphology1.20645764
35MP0009780_abnormal_chondrocyte_physiolo1.17091349
36MP0002909_abnormal_adrenal_gland1.15324173
37MP0008775_abnormal_heart_ventricle1.14580634
38MP0001501_abnormal_sleep_pattern1.11467511
39MP0002166_altered_tumor_susceptibility1.10696290
40MP0002796_impaired_skin_barrier1.09848695
41MP0002254_reproductive_system_inflammat1.06600511
42MP0003045_fibrosis1.06469926
43MP0000343_altered_response_to1.00177833
44MP0001727_abnormal_embryo_implantation0.97771453
45MP0000750_abnormal_muscle_regeneration0.97642996
46MP0000751_myopathy0.95730500
47MP0010368_abnormal_lymphatic_system0.95556912
48MP0002933_joint_inflammation0.94552017
49MP0003221_abnormal_cardiomyocyte_apopto0.94236663
50MP0003566_abnormal_cell_adhesion0.90984544
51MP0002006_tumorigenesis0.88247027
52MP0003646_muscle_fatigue0.86647713
53MP0002139_abnormal_hepatobiliary_system0.85870190
54MP0006276_abnormal_autonomic_nervous0.85086624
55MP0005584_abnormal_enzyme/coenzyme_acti0.84746401
56MP0004084_abnormal_cardiac_muscle0.84139950
57MP0001764_abnormal_homeostasis0.83836811
58MP0004147_increased_porphyrin_level0.83060730
59MP0008961_abnormal_basal_metabolism0.82545814
60MP0003950_abnormal_plasma_membrane0.82396431
61MP0001756_abnormal_urination0.82036744
62MP0000767_abnormal_smooth_muscle0.81614385
63* MP0003186_abnormal_redox_activity0.78534367
64MP0006036_abnormal_mitochondrial_physio0.78389936
65MP0002638_abnormal_pupillary_reflex0.75932400
66* MP0001881_abnormal_mammary_gland0.74531481
67MP0002168_other_aberrant_phenotype0.74279249
68* MP0005385_cardiovascular_system_phenoty0.73513899
69* MP0001544_abnormal_cardiovascular_syste0.73513899
70MP0002332_abnormal_exercise_endurance0.73082540
71MP0005319_abnormal_enzyme/_coenzyme0.72280947
72* MP0005595_abnormal_vascular_smooth0.71861625
73* MP0005620_abnormal_muscle_contractility0.71487058
74MP0005379_endocrine/exocrine_gland_phen0.68924617
75* MP0003953_abnormal_hormone_level0.68664051
76MP0001177_atelectasis0.67800401
77* MP0004087_abnormal_muscle_fiber0.67191583
78* MP0003948_abnormal_gas_homeostasis0.66847187
79* MP0000759_abnormal_skeletal_muscle0.66260243
80MP0004782_abnormal_surfactant_physiolog0.66015923
81MP0000749_muscle_degeneration0.64821634
82MP0001944_abnormal_pancreas_morphology0.63989691
83MP0009672_abnormal_birth_weight0.61460393
84MP0005645_abnormal_hypothalamus_physiol0.60026004
85MP0001879_abnormal_lymphatic_vessel0.59926178
86MP0005332_abnormal_amino_acid0.59768236
87MP0000427_abnormal_hair_cycle0.58524141
88MP0004036_abnormal_muscle_relaxation0.58448489
89MP0005076_abnormal_cell_differentiation0.58362975
90MP0002295_abnormal_pulmonary_circulatio0.58113523
91MP0005508_abnormal_skeleton_morphology0.56448281
92MP0002108_abnormal_muscle_morphology0.56306266
93MP0005330_cardiomyopathy0.55992106
94MP0001533_abnormal_skeleton_physiology0.54844365
95MP0005266_abnormal_metabolism0.54712969
96MP0005360_urolithiasis0.54586406
97MP0005058_abnormal_lysosome_morphology0.53864585
98MP0004215_abnormal_myocardial_fiber0.52617842
99* MP0006138_congestive_heart_failure0.51491706
100MP0003075_altered_response_to0.50753063
101MP0001958_emphysema0.49324223
102* MP0003828_pulmonary_edema0.48648195
103* MP0009643_abnormal_urine_homeostasis0.48372622
104MP0005369_muscle_phenotype0.47207931
105MP0003879_abnormal_hair_cell0.47042321
106MP0004484_altered_response_of0.46344456
107MP0002998_abnormal_bone_remodeling0.46324359
108MP0003137_abnormal_impulse_conducting0.46239844
109* MP0005164_abnormal_response_to0.45973228
110MP0005165_increased_susceptibility_to0.45899178
111MP0005647_abnormal_sex_gland0.45767164
112MP0010630_abnormal_cardiac_muscle0.43273431
113MP0005167_abnormal_blood-brain_barrier0.42175798
114* MP0002972_abnormal_cardiac_muscle0.40715170
115MP0000598_abnormal_liver_morphology0.40604883
116MP0010234_abnormal_vibrissa_follicle0.40072531
117MP0000163_abnormal_cartilage_morphology0.39817864
118MP0005397_hematopoietic_system_phenotyp0.39475439
119MP0001545_abnormal_hematopoietic_system0.39475439
120* MP0009763_increased_sensitivity_to0.39450832
121MP0003279_aneurysm0.39096997
122* MP0000249_abnormal_blood_vessel0.38974283
123MP0002009_preneoplasia0.38365249
124MP0004858_abnormal_nervous_system0.38098291
125MP0004883_abnormal_blood_vessel0.37410696
126* MP0000230_abnormal_systemic_arterial0.36505477
127MP0005390_skeleton_phenotype0.36201675

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)8.95178411
2Acanthosis nigricans (HP:0000956)7.51867006
3Hypertriglyceridemia (HP:0002155)6.53191248
4Hyperglycinuria (HP:0003108)5.53616686
5Insulin-resistant diabetes mellitus (HP:0000831)4.84290269
6Complement deficiency (HP:0004431)4.70563773
7Abnormality of serine family amino acid metabolism (HP:0010894)4.60366767
8Abnormality of glycine metabolism (HP:0010895)4.60366767
9Difficulty running (HP:0009046)4.27715245
10Myoglobinuria (HP:0002913)3.96032478
11Long foot (HP:0001833)3.88519557
12Reduced subcutaneous adipose tissue (HP:0003758)3.76096570
13Insulin resistance (HP:0000855)3.68191269
14Growth hormone excess (HP:0000845)3.52864209
15Ankle contracture (HP:0006466)3.50114392
16Increased connective tissue (HP:0009025)3.49586852
17Abnormality of fatty-acid metabolism (HP:0004359)3.48972430
18Pigmentary retinal degeneration (HP:0001146)3.47565092
19Hypoalphalipoproteinemia (HP:0003233)3.43555829
20Increased muscle lipid content (HP:0009058)3.41975243
21Epidermoid cyst (HP:0200040)3.41460052
22Hypoglycemic coma (HP:0001325)3.37997300
23Bone cyst (HP:0012062)3.36531965
24Abnormality of complement system (HP:0005339)3.33741189
25Subcapsular cataract (HP:0000523)3.24094725
26Ketoacidosis (HP:0001993)3.22459471
27Back pain (HP:0003418)3.22020962
28Hydroxyprolinuria (HP:0003080)3.17627420
29Abnormality of proline metabolism (HP:0010907)3.17627420
30Nausea (HP:0002018)3.16672663
31Myocardial infarction (HP:0001658)3.14761055
32Hemorrhage of the eye (HP:0011885)3.13819313
33Type 1 muscle fiber predominance (HP:0003803)3.10952241
34Rhabdomyolysis (HP:0003201)3.09787967
35Vertebral compression fractures (HP:0002953)3.09251518
36Ketosis (HP:0001946)3.07973869
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.06283925
38Ectopia lentis (HP:0001083)3.05652501
39Multiple enchondromatosis (HP:0005701)3.05368080
40Hyperthyroidism (HP:0000836)3.01118197
41Hyperlipoproteinemia (HP:0010980)3.00958346
42Increased variability in muscle fiber diameter (HP:0003557)3.00411021
43Axonal loss (HP:0003447)2.97683116
44Broad metatarsal (HP:0001783)2.95141978
45Follicular hyperkeratosis (HP:0007502)2.93990107
46Cerebral aneurysm (HP:0004944)2.91432368
47Large hands (HP:0001176)2.91211783
48Polycythemia (HP:0001901)2.80251475
49Hyperglycinemia (HP:0002154)2.77865347
50Frequent falls (HP:0002359)2.70329210
51Spinal rigidity (HP:0003306)2.69751119
52Dicarboxylic aciduria (HP:0003215)2.65600328
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.65600328
54Thyroid-stimulating hormone excess (HP:0002925)2.64660269
55Hyperpituitarism (HP:0010514)2.64055385
56Skin nodule (HP:0200036)2.63871493
57Ileus (HP:0002595)2.61420201
58Striae distensae (HP:0001065)2.59526888
59Increased serum pyruvate (HP:0003542)2.56318858
60Pancreatitis (HP:0001733)2.55342878
61Hyperammonemia (HP:0001987)2.54220172
62Abnormality of skeletal muscle fiber size (HP:0012084)2.51591155
63Xanthomatosis (HP:0000991)2.50943209
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.50768185
65Colitis (HP:0002583)2.48159269
66Slender build (HP:0001533)2.48115481
67Toxemia of pregnancy (HP:0100603)2.47359764
68Infantile muscular hypotonia (HP:0008947)2.44540470
69Neck muscle weakness (HP:0000467)2.39698481
70Prenatal maternal abnormality (HP:0002686)2.39602795
71Decreased subcutaneous fat (HP:0001002)2.38272936
72Abnormal cartilage morphology (HP:0002763)2.34516809
73Facial shape deformation (HP:0011334)2.33446673
74Potter facies (HP:0002009)2.33446673
75Accelerated skeletal maturation (HP:0005616)2.32808792
76Facial diplegia (HP:0001349)2.32694336
77Lipoatrophy (HP:0100578)2.30177446
78Premature rupture of membranes (HP:0001788)2.26586330
79Hyperglycemia (HP:0003074)2.24616608
80Hypercholesterolemia (HP:0003124)2.24091605
81Lymphangioma (HP:0100764)2.23717101
82Polygenic inheritance (HP:0010982)2.23710404
83Pulmonary artery stenosis (HP:0004415)2.23391997
84Prominent supraorbital ridges (HP:0000336)2.19830069
85Tetraparesis (HP:0002273)2.19726331
86Enlarged penis (HP:0000040)2.19292824
87Muscle fiber splitting (HP:0003555)2.18474663
88Abnormality of glycolysis (HP:0004366)2.17076015
89Abnormality of subcutaneous fat tissue (HP:0001001)2.15786504
90Cervical subluxation (HP:0003308)2.11738911
91Aortic dissection (HP:0002647)2.09526204
92Abnormality of the periventricular white matter (HP:0002518)2.08676486
93Gowers sign (HP:0003391)2.07027309
94Hyporeflexia of lower limbs (HP:0002600)2.06383149
95Venous abnormality (HP:0002624)2.04772970
96Abnormal hemoglobin (HP:0011902)2.04343203
97Abnormal eating behavior (HP:0100738)2.04160589
98Polar cataract (HP:0010696)2.04073691
99Turricephaly (HP:0000262)2.00008457
100Easy fatigability (HP:0003388)1.99198663
101Hypercortisolism (HP:0001578)1.98433554
102Megalocornea (HP:0000485)1.98220232
103Wormian bones (HP:0002645)1.98206971
104Muscle stiffness (HP:0003552)1.97268952
105Aortic aneurysm (HP:0004942)1.94697340
106Vascular tortuosity (HP:0004948)1.93869928
107Systemic lupus erythematosus (HP:0002725)1.91581400
108Esophageal varix (HP:0002040)1.90911557
109Scapular winging (HP:0003691)1.88442731
110Shallow orbits (HP:0000586)1.87966369
111Protrusio acetabuli (HP:0003179)1.86143148
112Autoimmune thrombocytopenia (HP:0001973)1.84749906
113Glucose intolerance (HP:0000833)1.83859841
114Amyloidosis (HP:0011034)1.81181257
115Limb hypertonia (HP:0002509)1.80981478
116Generalized aminoaciduria (HP:0002909)1.80124945
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79892840
118Abnormality of alanine metabolism (HP:0010916)1.79892840
119Hyperalaninemia (HP:0003348)1.79892840
120Dilatation of the ascending aorta (HP:0005111)1.79546278
121Increased mean platelet volume (HP:0011877)1.78746060
122Proximal amyotrophy (HP:0007126)1.78518159
123Polyphagia (HP:0002591)1.78093465
124Conjunctival hamartoma (HP:0100780)1.77552874
125Atrioventricular block (HP:0001678)1.77396270
126Right ventricular cardiomyopathy (HP:0011663)1.76655230
127Mitral valve prolapse (HP:0001634)1.76106560
128Clitoromegaly (HP:0000057)1.75821539
129Mutism (HP:0002300)1.74933851
130Rectal prolapse (HP:0002035)1.73230784
131Myotonia (HP:0002486)1.72470072
132Hepatic necrosis (HP:0002605)1.72084282
133Asymmetric septal hypertrophy (HP:0001670)1.72024133
134Impulsivity (HP:0100710)1.71187640
135Prolonged bleeding time (HP:0003010)1.69109532
136Adactyly (HP:0009776)1.68590794
137Mesangial abnormality (HP:0001966)1.67647542
138Buphthalmos (HP:0000557)1.67345241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D6.51337072
2TRIB35.58375372
3CAMK1G4.73622967
4SIK14.51772950
5BCKDK4.36094134
6PDK33.04043442
7PDK43.04043442
8LMTK22.63006364
9RIPK12.55367414
10ERN12.37609074
11MST1R2.23473469
12TESK11.99411482
13CDK91.81222131
14PRKAA21.80381020
15FGFR21.78949472
16PDK21.76211125
17MAPK41.75864102
18INSRR1.73806824
19NLK1.73092742
20FRK1.63076284
21FGFR31.62173987
22GRK51.55928672
23PDGFRA1.49463076
24PKN21.35874753
25EPHB21.33624790
26MAP2K11.23590544
27CDK61.23567699
28MOS1.20262385
29ARAF1.19954265
30PIK3CA1.17514649
31MAP3K131.16182929
32TRPM71.16146785
33STK38L1.09992200
34ADRBK11.05333680
35DDR21.03503481
36PRKD31.02826927
37JAK11.00762837
38RIPK41.00727256
39MET0.99309743
40TGFBR20.98996860
41LATS10.98703496
42PHKG20.93140202
43PHKG10.93140202
44PRKAA10.92543525
45KIT0.89464523
46MAP3K60.88627240
47FGFR40.87632478
48MYLK0.85630377
49FES0.83475350
50PDPK10.83419116
51TTN0.83328489
52TIE10.80520796
53JAK20.79051793
54PRKG10.78978849
55CAMKK20.76863686
56PRKCH0.73483719
57FER0.72326500
58RET0.72118456
59NEK90.71865573
60LATS20.71376222
61FLT30.69365482
62PDGFRB0.67154606
63PDK10.67077797
64GRK10.65603916
65MTOR0.65448442
66IGF1R0.64568807
67TYK20.64409446
68ILK0.64392150
69CDC42BPA0.64017848
70MAPK70.63439277
71FGFR10.62791135
72MAPK30.61346204
73MAPK110.61242118
74PKN10.60035296
75PRKACG0.58970391
76IRAK30.57877546
77PAK20.57859695
78KDR0.57212030
79GSK3A0.56708801
80STK380.55055912
81CAMK10.54684649
82PTK2B0.54546668
83BMX0.54157770
84PRKACB0.53303677
85PTK20.51481372
86JAK30.51073520
87CLK10.50412019
88INSR0.49311453
89CDK40.48734885
90PRKD10.48721408
91ZAP700.48058356
92SGK20.47794560
93RPS6KB10.47372530
94SGK4940.46085365
95SGK2230.46085365
96AKT20.41076672
97KSR20.41020433
98DAPK20.40985082
99EIF2AK20.37991975
100EEF2K0.37663366
101PINK10.37227279
102DAPK30.37023029
103PRKACA0.36404223
104CSF1R0.35796263
105SRC0.35071356
106PRKD20.33738310
107MAPK10.33425687
108TGFBR10.33174511
109ABL20.32994900
110MARK10.32882966
111MAP3K10.32614456
112MAPKAPK50.31891962
113SGK30.31604931
114YES10.31298619
115IRAK20.30938337
116CSK0.30720838
117IRAK10.30257730
118PRPF4B0.30248959
119PRKG20.30221728
120MAP2K40.30063574
121CAMKK10.29750067
122MARK20.29383625
123HIPK20.29297864
124MAP2K30.29096506
125LRRK20.28653036
126TBK10.28463147
127TNK20.27223216
128MAPK120.26502984
129EPHB10.26034819
130STK110.24781676
131STK30.23086026
132PAK60.22454324
133ABL10.22389494
134ICK0.21650967
135PTK60.19666017
136AKT10.19189096
137TYRO30.18897348
138MAPKAPK30.18312518
139PRKCZ0.16217880
140RPS6KA30.15261092
141CDK50.13336213
142EPHA30.11805518

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.88158965
2Propanoate metabolism_Homo sapiens_hsa006404.70423732
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.60523260
4* PPAR signaling pathway_Homo sapiens_hsa033204.16674749
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.80461667
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.79134956
7Fatty acid metabolism_Homo sapiens_hsa012123.53293699
8Glycerolipid metabolism_Homo sapiens_hsa005613.16757240
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.92268016
10Fatty acid degradation_Homo sapiens_hsa000712.91454686
11Pyruvate metabolism_Homo sapiens_hsa006202.32456428
12beta-Alanine metabolism_Homo sapiens_hsa004102.07247764
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95482316
14Histidine metabolism_Homo sapiens_hsa003401.94388800
15Carbon metabolism_Homo sapiens_hsa012001.86705510
16* AMPK signaling pathway_Homo sapiens_hsa041521.84033833
17Fat digestion and absorption_Homo sapiens_hsa049751.81899657
18* Adipocytokine signaling pathway_Homo sapiens_hsa049201.79078075
19Caffeine metabolism_Homo sapiens_hsa002321.70976876
20Nitrogen metabolism_Homo sapiens_hsa009101.66531864
21Peroxisome_Homo sapiens_hsa041461.52413394
22Butanoate metabolism_Homo sapiens_hsa006501.36902654
23Insulin resistance_Homo sapiens_hsa049311.33230623
24Phenylalanine metabolism_Homo sapiens_hsa003601.32510928
25Insulin signaling pathway_Homo sapiens_hsa049101.29582357
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22920504
27Vitamin B6 metabolism_Homo sapiens_hsa007501.21050679
28Staphylococcus aureus infection_Homo sapiens_hsa051501.19103872
29Tyrosine metabolism_Homo sapiens_hsa003501.14355379
30Fatty acid elongation_Homo sapiens_hsa000621.14027652
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03694353
32Glucagon signaling pathway_Homo sapiens_hsa049220.97434578
33Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97219156
34Malaria_Homo sapiens_hsa051440.95131954
35Pentose phosphate pathway_Homo sapiens_hsa000300.93430598
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91972815
37Renin secretion_Homo sapiens_hsa049240.87774248
38Glycerophospholipid metabolism_Homo sapiens_hsa005640.85779786
39ECM-receptor interaction_Homo sapiens_hsa045120.83344953
40Tryptophan metabolism_Homo sapiens_hsa003800.80800320
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78229463
42Retinol metabolism_Homo sapiens_hsa008300.76703201
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.68420377
44* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67572889
45* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64895495
46Protein digestion and absorption_Homo sapiens_hsa049740.63782128
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62976052
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62599885
49Biosynthesis of amino acids_Homo sapiens_hsa012300.57583671
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52681802
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51857673
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51392235
53ABC transporters_Homo sapiens_hsa020100.51163892
54Focal adhesion_Homo sapiens_hsa045100.51004770
55Dilated cardiomyopathy_Homo sapiens_hsa054140.50098943
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48461038
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.47324008
58Complement and coagulation cascades_Homo sapiens_hsa046100.46904793
59Starch and sucrose metabolism_Homo sapiens_hsa005000.44457145
60mTOR signaling pathway_Homo sapiens_hsa041500.43657276
61HIF-1 signaling pathway_Homo sapiens_hsa040660.42901508
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41906651
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41262019
64Arginine biosynthesis_Homo sapiens_hsa002200.40643639
65Lysine degradation_Homo sapiens_hsa003100.39548974
66Vitamin digestion and absorption_Homo sapiens_hsa049770.38528823
67Acute myeloid leukemia_Homo sapiens_hsa052210.38254906
68Fructose and mannose metabolism_Homo sapiens_hsa000510.35881013
69Dorso-ventral axis formation_Homo sapiens_hsa043200.33858981
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33597310
71Autoimmune thyroid disease_Homo sapiens_hsa053200.33577078
72Morphine addiction_Homo sapiens_hsa050320.32567632
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.31159574
74Thyroid cancer_Homo sapiens_hsa052160.30010866
75Arginine and proline metabolism_Homo sapiens_hsa003300.28862024
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28117225
77cAMP signaling pathway_Homo sapiens_hsa040240.27858279
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.26973997
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26741867
80Sulfur metabolism_Homo sapiens_hsa009200.26146432
81Proteoglycans in cancer_Homo sapiens_hsa052050.26125198
82Linoleic acid metabolism_Homo sapiens_hsa005910.24189690
83Folate biosynthesis_Homo sapiens_hsa007900.23288650
84Amoebiasis_Homo sapiens_hsa051460.21672462
85Melanoma_Homo sapiens_hsa052180.21297024
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20710862
87Arachidonic acid metabolism_Homo sapiens_hsa005900.20077176
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19424453
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19358924
90Small cell lung cancer_Homo sapiens_hsa052220.19274816
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19069684
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17480976
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16733423
94Sulfur relay system_Homo sapiens_hsa041220.15820105
95Lysosome_Homo sapiens_hsa041420.14766197
96Metabolic pathways_Homo sapiens_hsa011000.14589713
97Salivary secretion_Homo sapiens_hsa049700.14392972
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13935393
99Circadian rhythm_Homo sapiens_hsa047100.12903897
100Melanogenesis_Homo sapiens_hsa049160.12621545
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12607483
102Bile secretion_Homo sapiens_hsa049760.12343796
103FoxO signaling pathway_Homo sapiens_hsa040680.11581973
104Cocaine addiction_Homo sapiens_hsa050300.11285210
105Notch signaling pathway_Homo sapiens_hsa043300.10816796
106Viral myocarditis_Homo sapiens_hsa054160.09990699
107Toxoplasmosis_Homo sapiens_hsa051450.09868821
108Rap1 signaling pathway_Homo sapiens_hsa040150.09643109
109Thyroid hormone synthesis_Homo sapiens_hsa049180.09533091
110Chemical carcinogenesis_Homo sapiens_hsa052040.09203996
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.08047766
112Renin-angiotensin system_Homo sapiens_hsa046140.07877659
113* Type II diabetes mellitus_Homo sapiens_hsa049300.07839036
114Glioma_Homo sapiens_hsa052140.07683044
115Gap junction_Homo sapiens_hsa045400.07460569
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.07331948
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07249247
118Platelet activation_Homo sapiens_hsa046110.07048342
119Oxytocin signaling pathway_Homo sapiens_hsa049210.06939081
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06367028
121Glutathione metabolism_Homo sapiens_hsa004800.06102763
122Ovarian steroidogenesis_Homo sapiens_hsa049130.05268798
123Estrogen signaling pathway_Homo sapiens_hsa049150.05047431
124Adherens junction_Homo sapiens_hsa045200.04784441
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.04022280
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.03796793
127Chronic myeloid leukemia_Homo sapiens_hsa052200.03676247
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.03007142
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.02441065
130Pathways in cancer_Homo sapiens_hsa052000.02415862
131Prion diseases_Homo sapiens_hsa050200.01169024
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.00448700

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