ADIPOR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.70747861
2negative regulation of cell killing (GO:0031342)5.70747861
3positive regulation of gamma-delta T cell activation (GO:0046645)5.63200593
4neutrophil activation involved in immune response (GO:0002283)5.38473787
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.37926654
6positive regulation by symbiont of host defense response (GO:0052509)5.14062368
7modulation by symbiont of host defense response (GO:0052031)5.14062368
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.14062368
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.14062368
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.14062368
11modulation by symbiont of host immune response (GO:0052553)5.14062368
12regulation of B cell receptor signaling pathway (GO:0050855)4.69910199
13microglial cell activation (GO:0001774)4.46414100
14detection of molecule of bacterial origin (GO:0032490)4.34690022
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.28436422
16detection of other organism (GO:0098543)4.17872623
17macrophage activation involved in immune response (GO:0002281)4.14893689
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.13792831
19regulation of gamma-delta T cell activation (GO:0046643)4.10436887
20protoporphyrinogen IX metabolic process (GO:0046501)4.09415325
21antigen processing and presentation of endogenous antigen (GO:0019883)4.09243985
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.00738036
23regulation of gamma-delta T cell differentiation (GO:0045586)3.93750791
24detection of external biotic stimulus (GO:0098581)3.93508617
25regulation of platelet aggregation (GO:0090330)3.90574770
26neutrophil activation (GO:0042119)3.87221068
27detection of bacterium (GO:0016045)3.85149664
28cellular extravasation (GO:0045123)3.76562725
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.73107350
30macrophage activation (GO:0042116)3.71142558
31response to peptidoglycan (GO:0032494)3.68384740
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.67742658
33response to host immune response (GO:0052572)3.67742658
34negative regulation of interleukin-12 production (GO:0032695)3.65364531
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.63005941
36granulocyte activation (GO:0036230)3.55417788
37neutrophil mediated immunity (GO:0002446)3.54324766
38negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.46479051
39respiratory burst (GO:0045730)3.45976580
40low-density lipoprotein particle clearance (GO:0034383)3.43084088
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.41355675
42response to host (GO:0075136)3.41355675
43response to host defenses (GO:0052200)3.41355675
44regulation of necroptotic process (GO:0060544)3.39867691
45leukocyte aggregation (GO:0070486)3.39527329
46regulation of interferon-beta biosynthetic process (GO:0045357)3.38852706
47myeloid cell activation involved in immune response (GO:0002275)3.38108648
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.34494208
49regulation of mast cell degranulation (GO:0043304)3.34063152
50detection of biotic stimulus (GO:0009595)3.33857223
51positive regulation of receptor recycling (GO:0001921)3.32916169
52positive regulation of granulocyte differentiation (GO:0030854)3.32506743
53negative regulation of T cell mediated immunity (GO:0002710)3.29099476
54negative regulation of leukocyte mediated immunity (GO:0002704)3.27870337
55response to interleukin-15 (GO:0070672)3.25423451
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.20446159
57protoporphyrinogen IX biosynthetic process (GO:0006782)3.20293642
58positive regulation of mast cell activation (GO:0033005)3.17128600
59B cell receptor signaling pathway (GO:0050853)3.15082802
60antigen processing and presentation via MHC class Ib (GO:0002475)3.13541510
61positive regulation of p38MAPK cascade (GO:1900745)3.13079250
62negative regulation of erythrocyte differentiation (GO:0045647)3.12888980
63porphyrin-containing compound biosynthetic process (GO:0006779)3.12373504
64regulation of myeloid leukocyte mediated immunity (GO:0002886)3.09694950
65oxygen transport (GO:0015671)3.09679755
66myeloid leukocyte mediated immunity (GO:0002444)3.08287890
67bundle of His cell to Purkinje myocyte communication (GO:0086069)3.04826707
68regulation of mast cell activation involved in immune response (GO:0033006)3.04497285
69negative T cell selection (GO:0043383)3.03381230
70pentose-phosphate shunt (GO:0006098)3.01640021
71sequestering of metal ion (GO:0051238)3.00029590
72negative thymic T cell selection (GO:0045060)2.98437165
73regulation of skeletal muscle contraction (GO:0014819)2.98081085
74regulation of leukocyte degranulation (GO:0043300)2.97745927
75positive thymic T cell selection (GO:0045059)2.94304327
76negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93318313
77positive regulation of B cell differentiation (GO:0045579)2.92800738
78leukocyte degranulation (GO:0043299)2.92449025
79heme biosynthetic process (GO:0006783)2.92037336
80negative regulation of necroptotic process (GO:0060546)2.91682613
81creatine metabolic process (GO:0006600)2.90452105
82hemoglobin metabolic process (GO:0020027)2.90415704
83protein localization to endosome (GO:0036010)2.87493206
84positive regulation of Cdc42 GTPase activity (GO:0043089)2.87247881
85positive regulation of cellular amide metabolic process (GO:0034250)2.85999812
86NADPH regeneration (GO:0006740)2.85840030
87negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.85292085
88immunoglobulin mediated immune response (GO:0016064)2.85288754
89desmosome organization (GO:0002934)2.84392791
90cellular response to interleukin-15 (GO:0071350)2.82273348
91negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.81896454
92regulation of B cell differentiation (GO:0045577)2.81265941
93negative regulation of fatty acid transport (GO:2000192)2.80697217
94regulation of mast cell activation (GO:0033003)2.79733907
95valine metabolic process (GO:0006573)2.77735333
96dendritic cell migration (GO:0036336)2.75856490
97regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.74922576
98regulation of cholesterol storage (GO:0010885)2.74516323
99regulation of regulatory T cell differentiation (GO:0045589)2.74132935
100positive T cell selection (GO:0043368)2.74102577
101lipopolysaccharide-mediated signaling pathway (GO:0031663)2.69506987
102regulation of alpha-beta T cell proliferation (GO:0046640)2.68418086
103amyloid precursor protein catabolic process (GO:0042987)2.67694594
104muscle filament sliding (GO:0030049)2.67078189
105actin-myosin filament sliding (GO:0033275)2.67078189
106megakaryocyte development (GO:0035855)2.64971027
107negative regulation of glycoprotein biosynthetic process (GO:0010561)2.64400007
108negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.64304333
109regulation of p38MAPK cascade (GO:1900744)2.63765808
110myeloid leukocyte activation (GO:0002274)2.61931728
111production of molecular mediator involved in inflammatory response (GO:0002532)2.61326479
112tetrapyrrole biosynthetic process (GO:0033014)2.60839458
1134-hydroxyproline metabolic process (GO:0019471)2.60639093
114skin morphogenesis (GO:0043589)2.59238803
115porphyrin-containing compound metabolic process (GO:0006778)2.58652970
116activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58087327
117type I interferon signaling pathway (GO:0060337)2.57671060
118cellular response to type I interferon (GO:0071357)2.57671060
119regulation of amyloid precursor protein catabolic process (GO:1902991)2.57623253
120apoptotic cell clearance (GO:0043277)2.57113249
121negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.56674876
122negative regulation of T-helper cell differentiation (GO:0045623)2.56674876
123response to laminar fluid shear stress (GO:0034616)2.55935754
124T cell selection (GO:0045058)2.55894551
125regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.55077294
126response to type I interferon (GO:0034340)2.54860139
127positive regulation of triglyceride biosynthetic process (GO:0010867)2.53964610
128sulfur amino acid catabolic process (GO:0000098)2.52307912
129adhesion of symbiont to host (GO:0044406)2.51474368
130positive regulation of triglyceride metabolic process (GO:0090208)2.49116959
131regulation of sequestering of triglyceride (GO:0010889)2.47831520
132positive regulation of nuclease activity (GO:0032075)2.47772932
133regulation of rhodopsin mediated signaling pathway (GO:0022400)2.46418166
134sarcomere organization (GO:0045214)2.45464445
135maternal placenta development (GO:0001893)2.45417686
136leukocyte migration involved in inflammatory response (GO:0002523)2.44867157
137endoplasmic reticulum unfolded protein response (GO:0030968)2.43106236
138fatty acid beta-oxidation (GO:0006635)2.42471191
139NADP metabolic process (GO:0006739)2.41830625
140heme metabolic process (GO:0042168)2.40841068
141positive regulation of fatty acid beta-oxidation (GO:0032000)2.40435866
142epithelial cell-cell adhesion (GO:0090136)2.39858307
143rhodopsin mediated signaling pathway (GO:0016056)2.38738732
144response to arsenic-containing substance (GO:0046685)2.37663773
145cellular response to unfolded protein (GO:0034620)2.36643203
146adhesion of symbiont to host cell (GO:0044650)2.35257305
147virion attachment to host cell (GO:0019062)2.35257305
148Golgi transport vesicle coating (GO:0048200)2.35226450
149COPI coating of Golgi vesicle (GO:0048205)2.35226450
150hemidesmosome assembly (GO:0031581)2.33564320
151endodermal cell differentiation (GO:0035987)2.33186452
152ER-nucleus signaling pathway (GO:0006984)2.32208253
153positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.31302530
154ethanol oxidation (GO:0006069)2.30906389
155fatty acid transmembrane transport (GO:1902001)2.29996677
156basement membrane organization (GO:0071711)2.29477028
157response to methylmercury (GO:0051597)2.29263057
158hepatocyte apoptotic process (GO:0097284)2.27694202
159cell adhesion mediated by integrin (GO:0033627)2.26675566
160regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.26419131
161glucose catabolic process (GO:0006007)2.25643016
162mannose metabolic process (GO:0006013)2.24485238
163cysteine metabolic process (GO:0006534)2.24100933
164surfactant homeostasis (GO:0043129)2.23295268
165carnitine shuttle (GO:0006853)2.22756016
166regulation of nuclease activity (GO:0032069)2.21799560
167maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.21521509
168antimicrobial humoral response (GO:0019730)2.21402841
169atrioventricular valve morphogenesis (GO:0003181)2.21372405
170membrane raft organization (GO:0031579)2.20754315
171lysine catabolic process (GO:0006554)2.19966524
172lysine metabolic process (GO:0006553)2.19966524
173plasma lipoprotein particle clearance (GO:0034381)2.19763745
174barbed-end actin filament capping (GO:0051016)2.19685901
175cellular response to topologically incorrect protein (GO:0035967)2.19478173
176ethanol metabolic process (GO:0006067)2.19081653
177antibacterial humoral response (GO:0019731)2.18431926
178actin-mediated cell contraction (GO:0070252)2.18296885
179positive regulation of fatty acid oxidation (GO:0046321)2.18200491
180growth hormone receptor signaling pathway (GO:0060396)2.18030503
181regulation of cholesterol homeostasis (GO:2000188)2.17146632
182membrane protein ectodomain proteolysis (GO:0006509)2.17070225
183cellular response to arsenic-containing substance (GO:0071243)2.16990672
184myelin maintenance (GO:0043217)2.16790649
185* fatty acid oxidation (GO:0019395)2.16596961
186protein retention in ER lumen (GO:0006621)2.16447329
187regulation of fatty acid beta-oxidation (GO:0031998)2.14822552
188negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.14197919
189regulation of membrane protein ectodomain proteolysis (GO:0051043)2.13693909
190regulation of triglyceride catabolic process (GO:0010896)2.13373570
191* lipid oxidation (GO:0034440)2.12657408
192alpha-linolenic acid metabolic process (GO:0036109)2.11651042
193iron ion import (GO:0097286)2.10880952
194regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.10138965
195regulation of cholesterol metabolic process (GO:0090181)2.09002820
196protein-lipid complex assembly (GO:0065005)2.08491200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.83215803
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.58913744
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37819324
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.29491899
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.29082791
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79343840
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.69770019
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.67912710
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57139930
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.55968122
11CLOCK_20551151_ChIP-Seq_293T_Human2.54994174
12SPI1_23127762_ChIP-Seq_K562_Human2.49024167
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45833336
14SPI1_23547873_ChIP-Seq_NB4_Human2.44814518
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44725455
16RUNX_20019798_ChIP-Seq_JUKART_Human2.43799522
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41669119
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36420722
19ZNF263_19887448_ChIP-Seq_K562_Human2.35600593
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.26355696
21MYB_26560356_Chip-Seq_TH2_Human2.25493047
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24566361
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21534960
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.11531924
25GATA1_22025678_ChIP-Seq_K562_Human2.04917419
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.04034379
27LXR_22158963_ChIP-Seq_LIVER_Mouse2.02168973
28MYB_26560356_Chip-Seq_TH1_Human2.00432692
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98329694
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.95023080
31* ELK3_25401928_ChIP-Seq_HUVEC_Human1.90608245
32* GATA1_19941826_ChIP-Seq_K562_Human1.86008505
33* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80663233
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.80490791
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.75281719
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75228308
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72753899
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70467170
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70325099
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68488322
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68098354
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63312366
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.60169530
44GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60096857
45GATA3_27048872_Chip-Seq_THYMUS_Human1.59266949
46* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57395224
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56480386
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.55226946
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54930668
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54279603
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54262266
52* ATF3_27146783_Chip-Seq_COLON_Human1.54174025
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53950421
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52394193
55RACK7_27058665_Chip-Seq_MCF-7_Human1.51748942
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51129931
57MAF_26560356_Chip-Seq_TH2_Human1.48976049
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48867852
59SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46584435
60* PU_27001747_Chip-Seq_BMDM_Mouse1.45165614
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44601594
62VDR_21846776_ChIP-Seq_THP-1_Human1.44134982
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43534590
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42572993
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.42003524
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40290411
67* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40197093
68* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38135247
69* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37948981
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.36666628
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36441243
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36211654
73* GATA2_19941826_ChIP-Seq_K562_Human1.34365315
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34167168
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34002551
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33025547
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32854756
78MAF_26560356_Chip-Seq_TH1_Human1.32693679
79* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32298022
80* GATA1_19941827_ChIP-Seq_MEL_Mouse1.31803673
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31452378
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30111931
83* GATA2_21666600_ChIP-Seq_HMVEC_Human1.28011746
84* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27599910
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27252942
86VDR_24787735_ChIP-Seq_THP-1_Human1.25391986
87* KDM2B_26808549_Chip-Seq_DND41_Human1.24932518
88LXR_22292898_ChIP-Seq_THP-1_Human1.24276094
89TBX20_22328084_ChIP-Seq_HEART_Mouse1.24234505
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.24234505
91* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23806678
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23665383
93TCF7_22412390_ChIP-Seq_EML_Mouse1.23444556
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21713317
95FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.21600431
96* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20891239
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18881154
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18881154
99GATA4_25053715_ChIP-Seq_YYC3_Human1.17525818
100* GATA6_25053715_ChIP-Seq_YYC3_Human1.16375856
101NCOR1_26117541_ChIP-Seq_K562_Human1.16013808
102* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15346255
103EGR1_19374776_ChIP-ChIP_THP-1_Human1.15341173
104* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14926104
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14127439
106UTX_26944678_Chip-Seq_JUKART_Human1.13443185
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12634589
108VDR_24763502_ChIP-Seq_THP-1_Human1.12423855
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12146940
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11775217
111RUNX1_22412390_ChIP-Seq_EML_Mouse1.11679796
112* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11366577
113* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10846143
114* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10412898
115GATA3_26560356_Chip-Seq_TH2_Human1.10281842
116* UBF1/2_26484160_Chip-Seq_HMECs_Human1.09448390
117MYC_22102868_ChIP-Seq_BL_Human1.08283230
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08029728
119* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07287458
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07148122
121IRF8_27001747_Chip-Seq_BMDM_Mouse1.06584230
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05460222
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05198098
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05176778
125KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04356231
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03045538
127IRF8_22096565_ChIP-ChIP_GC-B_Human1.01892370
128SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01145335
129GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00953542
130KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00601299
131SCL_19346495_ChIP-Seq_HPC-7_Human1.00522972
132GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99561537
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98787415
134* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98776245
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.98332687
136PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98324471
137STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98152785
138FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96588495
139KDM2B_26808549_Chip-Seq_JURKAT_Human0.96429601
140TFEB_21752829_ChIP-Seq_HELA_Human0.95541981
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95479166
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94425606
143SOX2_20726797_ChIP-Seq_SW620_Human0.93865829
144EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93774252
145* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93728662
146JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92776663
147BCOR_27268052_Chip-Seq_Bcells_Human0.92619347
148CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92400996
149CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91562146
150GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91442334
151RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91220052
152* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89910578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.08258118
2MP0003656_abnormal_erythrocyte_physiolo2.82482077
3MP0003705_abnormal_hypodermis_morpholog2.80631264
4MP0003011_delayed_dark_adaptation2.73050352
5MP0005451_abnormal_body_composition2.57053771
6MP0005058_abnormal_lysosome_morphology2.52975263
7MP0008438_abnormal_cutaneous_collagen2.44156031
8MP0005025_abnormal_response_to2.31247001
9MP0001800_abnormal_humoral_immune2.30389085
10MP0003763_abnormal_thymus_physiology2.22727886
11MP0009840_abnormal_foam_cell2.22680615
12MP0005000_abnormal_immune_tolerance2.21631089
13MP0003172_abnormal_lysosome_physiology2.20309356
14MP0000685_abnormal_immune_system2.20247107
15MP0004381_abnormal_hair_follicle2.18200520
16MP0009785_altered_susceptibility_to2.16285174
17MP0005671_abnormal_response_to2.15324120
18MP0003191_abnormal_cellular_cholesterol2.10147111
19MP0002723_abnormal_immune_serum2.07102617
20MP0002420_abnormal_adaptive_immunity2.05801762
21MP0001819_abnormal_immune_cell2.03528434
22MP0002452_abnormal_antigen_presenting2.01051275
23MP0005275_abnormal_skin_tensile2.00263930
24MP0002837_dystrophic_cardiac_calcinosis1.98895055
25MP0003950_abnormal_plasma_membrane1.97284997
26MP0002132_abnormal_respiratory_system1.96657239
27MP0001790_abnormal_immune_system1.96152432
28MP0005387_immune_system_phenotype1.96152432
29MP0002398_abnormal_bone_marrow1.90742213
30MP0003806_abnormal_nucleotide_metabolis1.84346117
31MP0002148_abnormal_hypersensitivity_rea1.84241374
32MP0003566_abnormal_cell_adhesion1.81841753
33MP0006082_CNS_inflammation1.77587559
34MP0005083_abnormal_biliary_tract1.75833428
35MP0004147_increased_porphyrin_level1.75657635
36MP0002877_abnormal_melanocyte_morpholog1.72783283
37MP0004185_abnormal_adipocyte_glucose1.72641395
38MP0000569_abnormal_digit_pigmentation1.70343311
39MP0003300_gastrointestinal_ulcer1.69482531
40MP0000716_abnormal_immune_system1.64235962
41MP0000015_abnormal_ear_pigmentation1.61003139
42MP0003436_decreased_susceptibility_to1.60438316
43MP0004883_abnormal_blood_vessel1.60148991
44MP0002722_abnormal_immune_system1.59660054
45MP0000689_abnormal_spleen_morphology1.58649630
46MP0010155_abnormal_intestine_physiology1.55122027
47MP0009333_abnormal_splenocyte_physiolog1.54788098
48MP0002139_abnormal_hepatobiliary_system1.54280175
49MP0003866_abnormal_defecation1.51561987
50MP0001845_abnormal_inflammatory_respons1.50412955
51MP0001851_eye_inflammation1.48203441
52MP0004084_abnormal_cardiac_muscle1.48084995
53MP0010234_abnormal_vibrissa_follicle1.47541800
54MP0000343_altered_response_to1.47342250
55MP0002429_abnormal_blood_cell1.47126603
56MP0005075_abnormal_melanosome_morpholog1.46836915
57MP0006054_spinal_hemorrhage1.44543773
58MP0000703_abnormal_thymus_morphology1.41325296
59MP0003279_aneurysm1.41299270
60MP0000750_abnormal_muscle_regeneration1.39966566
61MP0003303_peritoneal_inflammation1.39956755
62MP0002796_impaired_skin_barrier1.39499716
63MP0003453_abnormal_keratinocyte_physiol1.36638303
64MP0010352_gastrointestinal_tract_polyps1.35073710
65MP0008004_abnormal_stomach_pH1.33677281
66MP0000465_gastrointestinal_hemorrhage1.32032446
67MP0003183_abnormal_peptide_metabolism1.31789721
68MP0009278_abnormal_bone_marrow1.30456377
69MP0005666_abnormal_adipose_tissue1.30142199
70MP0005310_abnormal_salivary_gland1.29861886
71MP0005023_abnormal_wound_healing1.29234422
72MP0000749_muscle_degeneration1.29135985
73MP0004272_abnormal_basement_membrane1.29111454
74MP0002396_abnormal_hematopoietic_system1.27171941
75MP0005164_abnormal_response_to1.26472308
76MP0003221_abnormal_cardiomyocyte_apopto1.25136550
77MP0004130_abnormal_muscle_cell1.23473231
78MP0001958_emphysema1.23255355
79MP0005501_abnormal_skin_physiology1.22419113
80MP0004087_abnormal_muscle_fiber1.20941746
81MP0001533_abnormal_skeleton_physiology1.20870314
82MP0003724_increased_susceptibility_to1.20288055
83MP0004036_abnormal_muscle_relaxation1.19420953
84MP0001666_abnormal_nutrient_absorption1.17588753
85MP0002166_altered_tumor_susceptibility1.11414861
86MP0002060_abnormal_skin_morphology1.11406661
87MP0004808_abnormal_hematopoietic_stem1.09094356
88MP0003075_altered_response_to1.08751613
89MP0005330_cardiomyopathy1.08747923
90MP0003828_pulmonary_edema1.08467416
91MP0005076_abnormal_cell_differentiation1.07513592
92MP0004947_skin_inflammation1.07343543
93MP0004510_myositis1.06286725
94MP0010368_abnormal_lymphatic_system1.05123979
95MP0000733_abnormal_muscle_development1.04588720
96* MP0000609_abnormal_liver_physiology1.04537388
97MP0002998_abnormal_bone_remodeling1.04134037
98MP0000747_muscle_weakness1.04026980
99* MP0003186_abnormal_redox_activity1.03462250
100MP0005375_adipose_tissue_phenotype1.03180596
101MP0009763_increased_sensitivity_to1.01484268
102MP0010630_abnormal_cardiac_muscle1.01326176
103MP0009643_abnormal_urine_homeostasis1.01003335
104MP0005365_abnormal_bile_salt0.96688606
105MP0009384_cardiac_valve_regurgitation0.96558771
106MP0000858_altered_metastatic_potential0.95187172
107MP0005464_abnormal_platelet_physiology0.94854827
108MP0005360_urolithiasis0.93031147
109MP0005174_abnormal_tail_pigmentation0.89989443
110MP0005319_abnormal_enzyme/_coenzyme0.89462221
111MP0010329_abnormal_lipoprotein_level0.88298530
112MP0005397_hematopoietic_system_phenotyp0.88041021
113MP0001545_abnormal_hematopoietic_system0.88041021
114MP0002972_abnormal_cardiac_muscle0.87200797
115MP0008874_decreased_physiological_sensi0.87170888
116MP0001216_abnormal_epidermal_layer0.86713416
117MP0005551_abnormal_eye_electrophysiolog0.86478323
118MP0008260_abnormal_autophagy0.86165218
119MP0009765_abnormal_xenobiotic_induced0.85961475
120MP0000604_amyloidosis0.82639510
121MP0005670_abnormal_white_adipose0.82174010
122MP0009764_decreased_sensitivity_to0.81983935
123MP0003690_abnormal_glial_cell0.81746198
124* MP0000759_abnormal_skeletal_muscle0.81043372
125MP0000751_myopathy0.80846961
126MP0003091_abnormal_cell_migration0.80798555
127MP0005620_abnormal_muscle_contractility0.80714865
128MP0001663_abnormal_digestive_system0.79712337
129MP0002419_abnormal_innate_immunity0.79448403
130MP0002295_abnormal_pulmonary_circulatio0.79159358
131* MP0002118_abnormal_lipid_homeostasis0.78552117
132MP0000767_abnormal_smooth_muscle0.77947622
133MP0001544_abnormal_cardiovascular_syste0.77247381
134MP0005385_cardiovascular_system_phenoty0.77247381
135MP0004484_altered_response_of0.77153622
136MP0005253_abnormal_eye_physiology0.76382578
137MP0008875_abnormal_xenobiotic_pharmacok0.75787454
138MP0000249_abnormal_blood_vessel0.75684835
139MP0002138_abnormal_hepatobiliary_system0.75640274
140MP0002269_muscular_atrophy0.75121982
141MP0001879_abnormal_lymphatic_vessel0.74966823
142MP0009931_abnormal_skin_appearance0.74891504
143MP0004782_abnormal_surfactant_physiolog0.74049367
144MP0005085_abnormal_gallbladder_physiolo0.74039089
145MP0002006_tumorigenesis0.73868112
146MP0005167_abnormal_blood-brain_barrier0.73319300
147MP0005166_decreased_susceptibility_to0.73221341
148MP0002090_abnormal_vision0.73180127
149MP0004019_abnormal_vitamin_homeostasis0.72811181
150MP0005636_abnormal_mineral_homeostasis0.72708637
151MP0010678_abnormal_skin_adnexa0.72360222
152MP0002405_respiratory_system_inflammati0.71995354
153MP0005165_increased_susceptibility_to0.71759909
154MP0003448_altered_tumor_morphology0.71388422
155MP0002098_abnormal_vibrissa_morphology0.70896834
156MP0008469_abnormal_protein_level0.70499604
157MP0001243_abnormal_dermal_layer0.70418514
158MP0002019_abnormal_tumor_incidence0.70104460
159MP0005621_abnormal_cell_physiology0.70031423
160MP0000371_diluted_coat_color0.69987170
161MP0001853_heart_inflammation0.65090941
162MP0003795_abnormal_bone_structure0.64858802
163MP0003329_amyloid_beta_deposits0.63277567
164MP0002277_abnormal_respiratory_mucosa0.62619581
165MP0000490_abnormal_crypts_of0.61064177
166MP0004264_abnormal_extraembryonic_tissu0.60490904
167MP0003045_fibrosis0.56092329

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.45472886
2Hypochromic microcytic anemia (HP:0004840)5.26868361
3Recurrent abscess formation (HP:0002722)5.23933616
4Prolonged bleeding time (HP:0003010)4.95793756
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.72161660
6Gingival bleeding (HP:0000225)4.47090239
7Myositis (HP:0100614)4.21838717
8Epistaxis (HP:0000421)3.98496820
9Orchitis (HP:0100796)3.96876556
10Petechiae (HP:0000967)3.93425005
11Recurrent gram-negative bacterial infections (HP:0005420)3.79945887
12Gastrointestinal infarctions (HP:0005244)3.76890049
13Abnormal platelet volume (HP:0011876)3.75968362
14Abnormality of the heme biosynthetic pathway (HP:0010472)3.74455305
15Retrobulbar optic neuritis (HP:0100654)3.70837380
16Optic neuritis (HP:0100653)3.70837380
17T lymphocytopenia (HP:0005403)3.69603422
18Stomatitis (HP:0010280)3.69362613
19Right ventricular cardiomyopathy (HP:0011663)3.50669162
20Elevated erythrocyte sedimentation rate (HP:0003565)3.47922773
21Hypochromic anemia (HP:0001931)3.44867232
22Purpura (HP:0000979)3.41746495
23Muscle fiber splitting (HP:0003555)3.41589871
24Recurrent fungal infections (HP:0002841)3.40728613
25Obstructive lung disease (HP:0006536)3.38819291
26Chronic obstructive pulmonary disease (HP:0006510)3.38819291
27Increased mean platelet volume (HP:0011877)3.37519929
28Abnormality of T cell number (HP:0011839)3.36838572
29Hyporeflexia of lower limbs (HP:0002600)3.34616796
30Menorrhagia (HP:0000132)3.31463534
31Exercise-induced muscle cramps (HP:0003710)3.31393123
32Bony spicule pigmentary retinopathy (HP:0007737)3.30345362
33Recurrent skin infections (HP:0001581)3.29655885
34Gingivitis (HP:0000230)3.22483205
35Slow saccadic eye movements (HP:0000514)3.12124682
36Increased cerebral lipofuscin (HP:0011813)3.06379934
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.01951659
38Congenital stationary night blindness (HP:0007642)2.98103275
39Poikilocytosis (HP:0004447)2.94388537
40Arterial thrombosis (HP:0004420)2.87296886
41Mediastinal lymphadenopathy (HP:0100721)2.87057345
42Increased connective tissue (HP:0009025)2.85715948
43Keratoconjunctivitis sicca (HP:0001097)2.83415959
44Ventricular tachycardia (HP:0004756)2.82625914
45Pigmentary retinal degeneration (HP:0001146)2.80582403
46Premature rupture of membranes (HP:0001788)2.80023796
47Meningitis (HP:0001287)2.74643047
48Myoglobinuria (HP:0002913)2.74485537
49Encephalitis (HP:0002383)2.73053536
50Vacuolated lymphocytes (HP:0001922)2.71820253
51Exercise-induced myalgia (HP:0003738)2.71175012
52Central scotoma (HP:0000603)2.70378009
53Chest pain (HP:0100749)2.69789086
54Asymmetric septal hypertrophy (HP:0001670)2.65945254
55Increased IgE level (HP:0003212)2.64135395
56Recurrent viral infections (HP:0004429)2.61545002
57Dysostosis multiplex (HP:0000943)2.59847667
58Vasculitis (HP:0002633)2.58599105
59Inflammation of the large intestine (HP:0002037)2.55668828
60Cellulitis (HP:0100658)2.55578850
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.54650494
62Episodic fever (HP:0001954)2.54580409
63Muscle fiber inclusion bodies (HP:0100299)2.54427114
64Keratoconjunctivitis (HP:0001096)2.53194782
65Type 1 muscle fiber predominance (HP:0003803)2.52166132
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.51912318
67Leukocytosis (HP:0001974)2.51637563
68Anorexia (HP:0002039)2.51275250
69Gastrointestinal inflammation (HP:0004386)2.51124654
70Interstitial pulmonary disease (HP:0006530)2.50881383
71Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.50774481
72Chronic mucocutaneous candidiasis (HP:0002728)2.45566276
73Recurrent cutaneous fungal infections (HP:0011370)2.45566276
74Rhabdomyolysis (HP:0003201)2.45373356
75Difficulty running (HP:0009046)2.44341501
76Abnormality of T cells (HP:0002843)2.43604579
77Conjunctival hamartoma (HP:0100780)2.41100586
78Scotoma (HP:0000575)2.39074223
79Distal arthrogryposis (HP:0005684)2.38768269
80Xanthomatosis (HP:0000991)2.37208530
81Polycythemia (HP:0001901)2.35783950
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.34243249
83Osteolytic defects of the hand bones (HP:0009699)2.34243249
84Cholelithiasis (HP:0001081)2.32996108
85Abolished electroretinogram (ERG) (HP:0000550)2.31380668
86Abnormal platelet function (HP:0011869)2.29271472
87Impaired platelet aggregation (HP:0003540)2.29271472
88Hypoglycemic coma (HP:0001325)2.29244361
89Granulocytopenia (HP:0001913)2.27144912
90Ulnar deviation of the wrist (HP:0003049)2.26597276
91Orthostatic hypotension (HP:0001278)2.26500443
92Difficulty climbing stairs (HP:0003551)2.26344742
93Round ear (HP:0100830)2.25609463
94Hematochezia (HP:0002573)2.25026885
95Protrusio acetabuli (HP:0003179)2.24813954
96Visual hallucinations (HP:0002367)2.23272104
97Chorioretinal atrophy (HP:0000533)2.22729442
98Abnormal rod and cone electroretinograms (HP:0008323)2.22329110
99Abnormal gallbladder morphology (HP:0012437)2.19399913
100Acute hepatic failure (HP:0006554)2.18317430
101Eczematoid dermatitis (HP:0000976)2.18032691
102Deep venous thrombosis (HP:0002625)2.17691629
103Reticulocytosis (HP:0001923)2.17668537
104Pulmonary embolism (HP:0002204)2.16521136
105Osteomyelitis (HP:0002754)2.16055781
106Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15989278
107Nemaline bodies (HP:0003798)2.15883486
108Abnormal gallbladder physiology (HP:0012438)2.14466121
109Cholecystitis (HP:0001082)2.14466121
110Distal lower limb muscle weakness (HP:0009053)2.14365555
111Increased serum ferritin (HP:0003281)2.13571053
112Muscle stiffness (HP:0003552)2.11276700
113Pustule (HP:0200039)2.10898130
114Myopathic facies (HP:0002058)2.10146408
115Axonal loss (HP:0003447)2.09482218
116Hemoptysis (HP:0002105)2.08290051
117Sudden death (HP:0001699)2.06766382
118Cerebral aneurysm (HP:0004944)2.06360753
119Amyloidosis (HP:0011034)2.05993016
120Peritonitis (HP:0002586)2.05532255
121Aortic aneurysm (HP:0004942)2.05055408
122Bruising susceptibility (HP:0000978)2.04847956
123Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04762662
124Abnormality of fatty-acid metabolism (HP:0004359)2.03648344
125Subacute progressive viral hepatitis (HP:0006572)2.03391400
126Myocardial infarction (HP:0001658)2.03156686
127Autoimmune hemolytic anemia (HP:0001890)2.03058624
128Postural instability (HP:0002172)2.02779550
129Conjunctival telangiectasia (HP:0000524)2.02706627
130Paralysis (HP:0003470)2.01507571
131EMG: myopathic abnormalities (HP:0003458)2.01476597
132Hypoalphalipoproteinemia (HP:0003233)2.01407850
133Abnormality of macular pigmentation (HP:0008002)2.00853700
134Fatigue (HP:0012378)1.98458233
135Abnormality of transition element cation homeostasis (HP:0011030)1.98095719
136Colitis (HP:0002583)1.96485118
137Abnormality of iron homeostasis (HP:0011031)1.96273710
138Pulmonary infiltrates (HP:0002113)1.95336858
139Toxemia of pregnancy (HP:0100603)1.95299533
140Urticaria (HP:0001025)1.94712097
141Cone-rod dystrophy (HP:0000548)1.94480377
142Diaphragmatic weakness (HP:0009113)1.94341044
143Abnormality of glycolipid metabolism (HP:0010969)1.93463225
144Abnormality of liposaccharide metabolism (HP:0010968)1.93463225
145Abnormality of glycosphingolipid metabolism (HP:0004343)1.93463225
146Palpitations (HP:0001962)1.93365531
147Hepatosplenomegaly (HP:0001433)1.92550615
148Increased IgM level (HP:0003496)1.91031770
149Flat acetabular roof (HP:0003180)1.90793533
150Gangrene (HP:0100758)1.90576957
151Progressive visual loss (HP:0000529)1.89927743
152Fragile skin (HP:0001030)1.89870930
153Urinary glycosaminoglycan excretion (HP:0003541)1.89644249
154Mucopolysacchariduria (HP:0008155)1.89644249
155Abnormality of macrophages (HP:0004311)1.89251569
156Eosinophilia (HP:0001880)1.88571295
157Abnormality of the peritoneum (HP:0002585)1.88487654
158Lipoatrophy (HP:0100578)1.87787633
159Stridor (HP:0010307)1.86639175
160Dysautonomia (HP:0002459)1.85798450
161Facial diplegia (HP:0001349)1.85242064
162Short nail (HP:0001799)1.84287860
163Abnormality of skeletal muscle fiber size (HP:0012084)1.83448784
164Increased variability in muscle fiber diameter (HP:0003557)1.81835675
165Cerebral inclusion bodies (HP:0100314)1.81789339
166Skin ulcer (HP:0200042)1.80673777
167Viral hepatitis (HP:0006562)1.79991242
168Retinal atrophy (HP:0001105)1.78326484
169Beaking of vertebral bodies (HP:0004568)1.78251654
170Dyschromatopsia (HP:0007641)1.77753500
171Acanthosis nigricans (HP:0000956)1.76793829
172Esophageal varix (HP:0002040)1.76441024
173Vertebral compression fractures (HP:0002953)1.74757006
174Systemic lupus erythematosus (HP:0002725)1.74754994
175Hand muscle atrophy (HP:0009130)1.73747919
176Spinal rigidity (HP:0003306)1.73414805
177Distal upper limb amyotrophy (HP:0007149)1.73409520
178Upper limb amyotrophy (HP:0009129)1.73409520
179Acanthocytosis (HP:0001927)1.73102772
180Nonimmune hydrops fetalis (HP:0001790)1.72535677
181Dilated cardiomyopathy (HP:0001644)1.72277074
182Metaphyseal cupping (HP:0003021)1.68837085
183Microcytic anemia (HP:0001935)1.68157866
184Spontaneous hematomas (HP:0007420)1.67491174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.68318678
2TRIB34.32535180
3ERN13.19659518
4TTN2.89431487
5PKN22.76949528
6FGR2.62919293
7EPHB12.45982243
8IRAK42.41213220
9MAP4K12.38078297
10TGFBR22.24002716
11TAOK12.18939786
12BCKDK2.05206285
13FES2.02026230
14MAP3K31.98109251
15STK101.89568731
16MAPKAPK31.87529400
17LRRK21.86020688
18PTK2B1.76910133
19IKBKE1.76047102
20TAOK21.75628277
21MAP2K31.74436107
22PRPF4B1.72244659
23SYK1.71874364
24KDR1.70713018
25PTK61.67417484
26TRPM71.66636059
27PIK3CG1.59425741
28HCK1.58280662
29MAP3K11.56089656
30MAP2K21.48081632
31SIK11.44902587
32BMPR21.40561152
33EPHA21.40293673
34TAOK31.37611235
35GRK51.35732772
36PIM21.35684923
37TXK1.34329320
38KSR21.32020777
39EEF2K1.30683542
40MET1.30436671
41MAP3K141.28789972
42TBK11.26431801
43TNK21.21632934
44TYK21.21048500
45GRK11.19257616
46PBK1.17189629
47DMPK1.15832864
48DYRK1B1.15226953
49LYN1.11833228
50PTK21.09958326
51MAP3K101.09947120
52NEK91.09250995
53FGFR41.06536057
54RIPK11.05626532
55RPS6KA41.04418658
56OBSCN1.02082335
57YES11.01094292
58TESK21.00048066
59IRAK10.99965638
60TEC0.99007000
61MAP3K110.98453224
62STK40.98282984
63PAK40.98056383
64RPS6KB20.97794320
65IRAK20.97634099
66TESK10.96279375
67SGK30.95744685
68MARK20.94723029
69EIF2AK30.94639151
70FLT30.94564704
71SIK30.92505868
72STK240.92345840
73LCK0.90351692
74MATK0.89477318
75CAMK1D0.87766969
76BLK0.87515898
77MAP3K50.86932883
78PIK3CA0.86767809
79MST1R0.86692310
80MAP3K130.86153432
81ILK0.84531775
82CSF1R0.83960008
83IKBKB0.82713328
84PIM10.82052534
85WNK40.80874615
86TLK10.80417924
87RAF10.80313046
88SGK20.79518351
89FGFR30.79215873
90PDK10.78916642
91MYLK0.76591084
92GRK60.75699520
93CDK60.75476775
94MST40.73254046
95MAP3K60.72564825
96MAP3K80.72175921
97MARK30.71651807
98PDPK10.70204076
99CSK0.69672055
100TIE10.69253706
101BMX0.69202464
102STK390.69164914
103KSR10.68943777
104SCYL20.68768854
105PRKD10.68714473
106PRKG20.67681335
107FRK0.66999694
108EPHA30.66392133
109JAK20.66176828
110DYRK30.65705413
111STK30.65109983
112FER0.64927853
113STK380.63722864
114SMG10.63359174
115MAPKAPK20.60370127
116NME20.59833101
117PAK20.58933758
118CDK120.58373098
119PHKG10.57918258
120PHKG20.57918258
121MAP2K10.56846193
122PRKAA20.56019748
123RPS6KA50.55431062
124ZAP700.54501864
125HIPK20.54198904
126MAP3K20.53996630
127GSK3A0.52948603
128LIMK10.52215919
129EPHB20.52111764
130FYN0.51709975
131PDGFRA0.51476228
132FGFR20.50474063
133RET0.50402042
134BTK0.50084269
135IRAK30.49530788
136ITK0.48960820
137MTOR0.48768021
138EIF2AK10.48423545
139PLK20.48231068
140RPS6KC10.47156652
141RPS6KL10.47156652
142LATS10.46883632
143WNK10.45614830
144CLK10.44677381
145MAPK110.44670658
146MOS0.44278895
147PDK20.44073672
148ERBB20.43959124
149RPS6KA60.43847351
150JAK30.43255057
151JAK10.42968174
152MAPK120.42057000
153CAMKK20.40539733
154SGK4940.37075261
155SGK2230.37075261
156PRKD20.34624599
157MAP2K40.34144625
158NLK0.33737174
159MAP3K70.31415082

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.28090677
2B cell receptor signaling pathway_Homo sapiens_hsa046622.37970854
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.21685107
4Fatty acid degradation_Homo sapiens_hsa000712.11658491
5Non-small cell lung cancer_Homo sapiens_hsa052232.02177342
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96516058
7Tuberculosis_Homo sapiens_hsa051521.94386586
8Selenocompound metabolism_Homo sapiens_hsa004501.83909911
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.80031289
10T cell receptor signaling pathway_Homo sapiens_hsa046601.77114611
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75142157
12Measles_Homo sapiens_hsa051621.74126112
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.72224217
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.71707628
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69961201
16Hematopoietic cell lineage_Homo sapiens_hsa046401.69241859
17Chemokine signaling pathway_Homo sapiens_hsa040621.67532709
18Lysosome_Homo sapiens_hsa041421.64793315
19Primary immunodeficiency_Homo sapiens_hsa053401.55663335
20Sulfur metabolism_Homo sapiens_hsa009201.52764551
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50314109
22Staphylococcus aureus infection_Homo sapiens_hsa051501.49945186
23Fatty acid metabolism_Homo sapiens_hsa012121.49271353
24Propanoate metabolism_Homo sapiens_hsa006401.47362734
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44007378
26Caffeine metabolism_Homo sapiens_hsa002321.43142623
27Influenza A_Homo sapiens_hsa051641.39192270
28Graft-versus-host disease_Homo sapiens_hsa053321.38757925
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.38346708
30Other glycan degradation_Homo sapiens_hsa005111.37227682
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.36079251
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35001314
33Fat digestion and absorption_Homo sapiens_hsa049751.31999334
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31483526
35PPAR signaling pathway_Homo sapiens_hsa033201.31187129
36ABC transporters_Homo sapiens_hsa020101.30938851
37Allograft rejection_Homo sapiens_hsa053301.29568134
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27337638
39Starch and sucrose metabolism_Homo sapiens_hsa005001.27086647
40Complement and coagulation cascades_Homo sapiens_hsa046101.25336109
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24894958
42Insulin resistance_Homo sapiens_hsa049311.24199885
43VEGF signaling pathway_Homo sapiens_hsa043701.24165599
44Hepatitis C_Homo sapiens_hsa051601.22997326
45Hepatitis B_Homo sapiens_hsa051611.22422331
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21815843
47TNF signaling pathway_Homo sapiens_hsa046681.19967493
48Autoimmune thyroid disease_Homo sapiens_hsa053201.18826446
49Fatty acid elongation_Homo sapiens_hsa000621.18305631
50Herpes simplex infection_Homo sapiens_hsa051681.16973671
51Carbon metabolism_Homo sapiens_hsa012001.15712552
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15260252
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13343377
54Histidine metabolism_Homo sapiens_hsa003401.13091608
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10543996
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10412696
57Endometrial cancer_Homo sapiens_hsa052131.10329309
58ECM-receptor interaction_Homo sapiens_hsa045121.08636034
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08405050
60Folate biosynthesis_Homo sapiens_hsa007901.07240622
61Glutathione metabolism_Homo sapiens_hsa004801.07203164
62Malaria_Homo sapiens_hsa051441.06428783
63Tryptophan metabolism_Homo sapiens_hsa003801.04792958
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03823114
65Focal adhesion_Homo sapiens_hsa045101.03685338
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02911147
67Sulfur relay system_Homo sapiens_hsa041221.02069502
68Antigen processing and presentation_Homo sapiens_hsa046121.00329419
69Prolactin signaling pathway_Homo sapiens_hsa049170.99412934
70Amoebiasis_Homo sapiens_hsa051460.99412068
71Leishmaniasis_Homo sapiens_hsa051400.98021438
72Thyroid cancer_Homo sapiens_hsa052160.97355118
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97314650
74Bladder cancer_Homo sapiens_hsa052190.96692715
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95684274
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.95412744
77Small cell lung cancer_Homo sapiens_hsa052220.95408278
78Systemic lupus erythematosus_Homo sapiens_hsa053220.94949294
79* Adipocytokine signaling pathway_Homo sapiens_hsa049200.94298456
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93605913
81FoxO signaling pathway_Homo sapiens_hsa040680.92906524
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92834109
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92829397
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91668425
85African trypanosomiasis_Homo sapiens_hsa051430.91575045
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91448491
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90649878
88Peroxisome_Homo sapiens_hsa041460.90536221
89Toxoplasmosis_Homo sapiens_hsa051450.88721085
90Nitrogen metabolism_Homo sapiens_hsa009100.88536586
91Apoptosis_Homo sapiens_hsa042100.85254787
92Pentose phosphate pathway_Homo sapiens_hsa000300.84738529
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.84420189
94Inositol phosphate metabolism_Homo sapiens_hsa005620.83414053
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82845080
96Proteoglycans in cancer_Homo sapiens_hsa052050.82677640
97Legionellosis_Homo sapiens_hsa051340.81881988
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.81769715
99mTOR signaling pathway_Homo sapiens_hsa041500.81537129
100Type I diabetes mellitus_Homo sapiens_hsa049400.81501525
101Pyruvate metabolism_Homo sapiens_hsa006200.80182850
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79422642
103Glycerolipid metabolism_Homo sapiens_hsa005610.77117102
104Adherens junction_Homo sapiens_hsa045200.77012927
105beta-Alanine metabolism_Homo sapiens_hsa004100.76680109
106Retinol metabolism_Homo sapiens_hsa008300.76323949
107Chemical carcinogenesis_Homo sapiens_hsa052040.75531952
108Chronic myeloid leukemia_Homo sapiens_hsa052200.75530842
109* AMPK signaling pathway_Homo sapiens_hsa041520.75439278
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73935428
111Choline metabolism in cancer_Homo sapiens_hsa052310.72686762
112Arginine biosynthesis_Homo sapiens_hsa002200.72525551
113Glioma_Homo sapiens_hsa052140.70917982
114Arginine and proline metabolism_Homo sapiens_hsa003300.70588379
115Steroid biosynthesis_Homo sapiens_hsa001000.70328248
116Tight junction_Homo sapiens_hsa045300.70287282
117Notch signaling pathway_Homo sapiens_hsa043300.69876060
118Osteoclast differentiation_Homo sapiens_hsa043800.67257657
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65197680
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.64938755
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64889535
122Protein digestion and absorption_Homo sapiens_hsa049740.64247676
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63166651
124Viral myocarditis_Homo sapiens_hsa054160.63157994
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.62789519
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62538538
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62176252
128Rheumatoid arthritis_Homo sapiens_hsa053230.61846671
129Galactose metabolism_Homo sapiens_hsa000520.61812170
130ErbB signaling pathway_Homo sapiens_hsa040120.60885487
131Prostate cancer_Homo sapiens_hsa052150.59153790
132Acute myeloid leukemia_Homo sapiens_hsa052210.58929023
133Phagosome_Homo sapiens_hsa041450.58773380
134Regulation of autophagy_Homo sapiens_hsa041400.58019184
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.57817597
136Collecting duct acid secretion_Homo sapiens_hsa049660.57467695
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57416494
138Phenylalanine metabolism_Homo sapiens_hsa003600.57103694
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56786122
140Renal cell carcinoma_Homo sapiens_hsa052110.56554501
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56370756
142Epstein-Barr virus infection_Homo sapiens_hsa051690.56332869
143Pancreatic cancer_Homo sapiens_hsa052120.56058947
144Dilated cardiomyopathy_Homo sapiens_hsa054140.55983899
145Viral carcinogenesis_Homo sapiens_hsa052030.55927226
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.55430630
147Pertussis_Homo sapiens_hsa051330.54877023
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.54596743
149Insulin signaling pathway_Homo sapiens_hsa049100.54280819
150Biosynthesis of amino acids_Homo sapiens_hsa012300.53570587
151Salmonella infection_Homo sapiens_hsa051320.53296452
152Endocytosis_Homo sapiens_hsa041440.52097776
153Platelet activation_Homo sapiens_hsa046110.51312416
154HIF-1 signaling pathway_Homo sapiens_hsa040660.51010694
155Shigellosis_Homo sapiens_hsa051310.51000833
156GnRH signaling pathway_Homo sapiens_hsa049120.50154339
157Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49196841
158Colorectal cancer_Homo sapiens_hsa052100.47886686
159Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47812236
160Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47732936
161HTLV-I infection_Homo sapiens_hsa051660.46759107
162Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46692899
163Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46676167

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