ADIPOR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.54590178
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.54590178
3L-phenylalanine metabolic process (GO:0006558)6.28138409
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.28138409
5alpha-linolenic acid metabolic process (GO:0036109)6.03814455
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.91460764
7aromatic amino acid family catabolic process (GO:0009074)5.69217515
8complement activation, alternative pathway (GO:0006957)5.18021493
9sulfur amino acid catabolic process (GO:0000098)5.14859549
10bile acid biosynthetic process (GO:0006699)5.13428495
11fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.06000183
12regulation of triglyceride catabolic process (GO:0010896)5.04865749
13urea cycle (GO:0000050)5.03861766
14urea metabolic process (GO:0019627)5.03861766
15kynurenine metabolic process (GO:0070189)4.99259815
16glyoxylate metabolic process (GO:0046487)4.96051830
17indole-containing compound catabolic process (GO:0042436)4.95559313
18indolalkylamine catabolic process (GO:0046218)4.95559313
19tryptophan catabolic process (GO:0006569)4.95559313
20cysteine metabolic process (GO:0006534)4.95180888
21high-density lipoprotein particle remodeling (GO:0034375)4.80265502
22protein carboxylation (GO:0018214)4.79617513
23peptidyl-glutamic acid carboxylation (GO:0017187)4.79617513
24regulation of protein activation cascade (GO:2000257)4.69584516
25negative regulation of fibrinolysis (GO:0051918)4.69428709
26tryptophan metabolic process (GO:0006568)4.67846127
27nitrogen cycle metabolic process (GO:0071941)4.64596104
28plasma lipoprotein particle clearance (GO:0034381)4.62244592
29acylglycerol homeostasis (GO:0055090)4.49211923
30triglyceride homeostasis (GO:0070328)4.49211923
31bile acid metabolic process (GO:0008206)4.48928759
32regulation of complement activation (GO:0030449)4.44113930
33lysine catabolic process (GO:0006554)4.43732993
34lysine metabolic process (GO:0006553)4.43732993
35regulation of fibrinolysis (GO:0051917)4.41279201
36serine family amino acid catabolic process (GO:0009071)4.40197330
37amino-acid betaine metabolic process (GO:0006577)4.38389526
38reverse cholesterol transport (GO:0043691)4.31183792
39phospholipid efflux (GO:0033700)4.28560237
40plasma lipoprotein particle remodeling (GO:0034369)4.25989286
41protein-lipid complex remodeling (GO:0034368)4.25989286
42macromolecular complex remodeling (GO:0034367)4.25989286
43homocysteine metabolic process (GO:0050667)4.24807364
44regulation of cholesterol esterification (GO:0010872)4.23462850
45positive regulation of fatty acid beta-oxidation (GO:0032000)4.22036681
46valine metabolic process (GO:0006573)4.21843027
47ethanol oxidation (GO:0006069)4.18565431
48positive regulation of lipid catabolic process (GO:0050996)4.14186830
49negative regulation of cholesterol transport (GO:0032375)4.11299959
50negative regulation of sterol transport (GO:0032372)4.11299959
51tyrosine metabolic process (GO:0006570)4.09824621
52acetyl-CoA metabolic process (GO:0006084)4.09803458
53aromatic amino acid family metabolic process (GO:0009072)4.07831763
54alpha-amino acid catabolic process (GO:1901606)4.07461699
55fatty acid beta-oxidation (GO:0006635)4.05727786
56COPI coating of Golgi vesicle (GO:0048205)4.00869246
57Golgi transport vesicle coating (GO:0048200)4.00869246
58low-density lipoprotein particle clearance (GO:0034383)3.97731891
59* fatty acid oxidation (GO:0019395)3.86717098
60cellular ketone body metabolic process (GO:0046950)3.85808674
61phospholipid homeostasis (GO:0055091)3.84311717
62cellular amino acid catabolic process (GO:0009063)3.84211869
63plasma lipoprotein particle assembly (GO:0034377)3.83123485
64cholesterol efflux (GO:0033344)3.82376844
65fatty acid catabolic process (GO:0009062)3.81833467
66coenzyme catabolic process (GO:0009109)3.81669449
67* lipid oxidation (GO:0034440)3.78803547
68short-chain fatty acid metabolic process (GO:0046459)3.78060285
69bile acid and bile salt transport (GO:0015721)3.75932440
70glycine metabolic process (GO:0006544)3.75446398
71fatty acid transmembrane transport (GO:1902001)3.75251461
72regulation of cholesterol homeostasis (GO:2000188)3.72992881
732-oxoglutarate metabolic process (GO:0006103)3.71884497
74negative regulation of lipase activity (GO:0060192)3.71580086
75proline biosynthetic process (GO:0006561)3.70747890
76monocarboxylic acid catabolic process (GO:0072329)3.68430670
77positive regulation of triglyceride lipase activity (GO:0061365)3.68419754
78positive regulation of lipoprotein lipase activity (GO:0051006)3.68419754
79serine family amino acid metabolic process (GO:0009069)3.64682677
80cholesterol homeostasis (GO:0042632)3.63750509
81glutamate metabolic process (GO:0006536)3.62127591
82positive regulation of fatty acid oxidation (GO:0046321)3.61745200
83regulation of sequestering of triglyceride (GO:0010889)3.60329831
84regulation of fatty acid beta-oxidation (GO:0031998)3.60265706
85triglyceride catabolic process (GO:0019433)3.59579263
86cellular glucuronidation (GO:0052695)3.59470862
87organic acid catabolic process (GO:0016054)3.59291344
88carboxylic acid catabolic process (GO:0046395)3.59291344
89sterol homeostasis (GO:0055092)3.58860806
90cellular modified amino acid catabolic process (GO:0042219)3.57823030
91acylglycerol catabolic process (GO:0046464)3.56449760
92neutral lipid catabolic process (GO:0046461)3.56449760
93protein-lipid complex assembly (GO:0065005)3.55776120
94biotin metabolic process (GO:0006768)3.54171998
95positive regulation of triglyceride metabolic process (GO:0090208)3.53461850
96very-low-density lipoprotein particle assembly (GO:0034379)3.53418465
97imidazole-containing compound metabolic process (GO:0052803)3.49849990
98benzene-containing compound metabolic process (GO:0042537)3.47378950
99carnitine metabolic process (GO:0009437)3.46663814
100indolalkylamine metabolic process (GO:0006586)3.43362551
101desmosome organization (GO:0002934)3.43027454
102NADH metabolic process (GO:0006734)3.42812916
103complement activation (GO:0006956)3.42481291
104plasma lipoprotein particle organization (GO:0071827)3.41892687
105dicarboxylic acid biosynthetic process (GO:0043650)3.41467996
106negative regulation of fatty acid transport (GO:2000192)3.40473720
107regulation of cholesterol biosynthetic process (GO:0045540)3.39966776
108focal adhesion assembly (GO:0048041)3.28713760
109cell-substrate adherens junction assembly (GO:0007045)3.28713760
110nuclear pore complex assembly (GO:0051292)3.27178999
111cytoskeletal anchoring at plasma membrane (GO:0007016)3.26061081
112protein localization to endosome (GO:0036010)3.24216982
113regulation of early endosome to late endosome transport (GO:2000641)3.20325064
114adherens junction assembly (GO:0034333)3.15264101
115negative regulation of fatty acid biosynthetic process (GO:0045717)3.12610397
116cell-substrate junction assembly (GO:0007044)3.10227155
117fatty acid homeostasis (GO:0055089)2.99212378
118mitotic chromosome condensation (GO:0007076)2.99016724
119retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.92404471
120proline metabolic process (GO:0006560)2.91584117
121hemidesmosome assembly (GO:0031581)2.90012017
122embryonic process involved in female pregnancy (GO:0060136)2.89073121
123regulation of nucleobase-containing compound transport (GO:0032239)2.88129522
124regulation of glucose import in response to insulin stimulus (GO:2001273)2.87936142
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86821142
126glutamine family amino acid biosynthetic process (GO:0009084)2.84045548
127regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.82124537
128positive regulation of extracellular matrix organization (GO:1903055)2.81733904
129protein retention in ER lumen (GO:0006621)2.79114615
130negative regulation of lipid transport (GO:0032369)2.78583000
131insulin-like growth factor receptor signaling pathway (GO:0048009)2.77232780
132COPII vesicle coating (GO:0048208)2.73898466
133tricarboxylic acid metabolic process (GO:0072350)2.73746313
134regulation of RNA export from nucleus (GO:0046831)2.72792319
135regulation of cholesterol metabolic process (GO:0090181)2.63830370
136glucose 6-phosphate metabolic process (GO:0051156)2.63698704
137vesicle coating (GO:0006901)2.61318595
138basement membrane organization (GO:0071711)2.55631940
139activation of Rac GTPase activity (GO:0032863)2.52844164
140triglyceride biosynthetic process (GO:0019432)2.52669535
141branching involved in mammary gland duct morphogenesis (GO:0060444)2.52549821
142skin morphogenesis (GO:0043589)2.51642600
143oxaloacetate metabolic process (GO:0006107)2.49378306
144negative regulation of protein localization to plasma membrane (GO:1903077)2.48841514
145triglyceride metabolic process (GO:0006641)2.48563560
146cellular protein complex localization (GO:0034629)2.47840468
147sodium ion export (GO:0071436)2.47688182
148stress fiber assembly (GO:0043149)2.47118166
149nuclear pore organization (GO:0006999)2.46583502
150regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46416877
151epithelial cell-cell adhesion (GO:0090136)2.45011312
152epoxygenase P450 pathway (GO:0019373)2.41551981
153acylglycerol biosynthetic process (GO:0046463)2.41160482
154neutral lipid biosynthetic process (GO:0046460)2.41160482
155intestinal absorption (GO:0050892)2.40562522
156activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.40162546
157surfactant homeostasis (GO:0043129)2.40130892
158mannose metabolic process (GO:0006013)2.38822595
159barbed-end actin filament capping (GO:0051016)2.38572578
160maternal placenta development (GO:0001893)2.37641806
161positive regulation of nuclease activity (GO:0032075)2.35763290
162negative regulation of cell size (GO:0045792)2.34916471
163acylglycerol metabolic process (GO:0006639)2.34125314
164long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.32960487
165regulation of histone H3-K27 methylation (GO:0061085)2.30356077
166neutral lipid metabolic process (GO:0006638)2.29953082
167response to mercury ion (GO:0046689)2.29878368
168linoleic acid metabolic process (GO:0043651)2.29130517
169regulation of fatty acid biosynthetic process (GO:0042304)2.27481803
170positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27232472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.42702089
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.31058349
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.50860869
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.90758205
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.65772044
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.57133069
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.22406307
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.67900642
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.24793193
10E2F7_22180533_ChIP-Seq_HELA_Human3.24254593
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.19089971
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.50532031
13* CLOCK_20551151_ChIP-Seq_293T_Human2.46512376
14AR_21909140_ChIP-Seq_LNCAP_Human2.08943761
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.01178309
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3639404
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97372918
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93169302
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.93038836
20GATA1_22025678_ChIP-Seq_K562_Human1.87991149
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85119715
22* MYC_22102868_ChIP-Seq_BL_Human1.83361270
23TCF7_22412390_ChIP-Seq_EML_Mouse1.71155532
24* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.70896594
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67868479
26* FOXA2_19822575_ChIP-Seq_HepG2_Human1.61852768
27P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60543289
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58853390
29VDR_21846776_ChIP-Seq_THP-1_Human1.52875216
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52523363
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51817635
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51624919
33* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49357882
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.47069656
35KDM2B_26808549_Chip-Seq_K562_Human1.45514014
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42482459
37TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41098436
38* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39118520
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37557178
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.33607259
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33004671
42* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32865011
43ZNF263_19887448_ChIP-Seq_K562_Human1.31561932
44* HNF4A_19822575_ChIP-Seq_HepG2_Human1.31348743
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30052461
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29984830
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29361784
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29245240
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27551647
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.26766212
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26201713
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26201713
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25040705
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24016276
55* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23011078
56KDM2B_26808549_Chip-Seq_DND41_Human1.21508439
57* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21350849
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21296027
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21183470
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19472996
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19379398
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17649710
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17405832
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.17012026
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15813027
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12745916
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10541212
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07678008
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.06491030
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06312927
71EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06028402
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05698244
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03395481
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01214556
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01199518
76* GATA4_25053715_ChIP-Seq_YYC3_Human1.01197878
77NCOR1_26117541_ChIP-Seq_K562_Human0.99765335
78CHD1_26751641_Chip-Seq_LNCaP_Human0.97787160
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97613054
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96656389
81* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96313164
82PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93855274
83* FOXO3_23340844_ChIP-Seq_DLD1_Human0.93580984
84RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93510255
85HTT_18923047_ChIP-ChIP_STHdh_Human0.92245471
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91669518
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88744632
88GATA1_19941826_ChIP-Seq_K562_Human0.87281291
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85076142
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84499055
91SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84330835
92PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.81462546
93LXR_22292898_ChIP-Seq_THP-1_Human0.81214329
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78142040
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77975669
96BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77659215
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77584564
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77517606
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77202368
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76158000
101GATA2_19941826_ChIP-Seq_K562_Human0.76076924
102ESR1_20079471_ChIP-ChIP_T-47D_Human0.75088946
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73742256
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73563786
105TP63_17297297_ChIP-ChIP_HaCaT_Human0.73361448
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73201146
107CDX2_20551321_ChIP-Seq_CACO-2_Human0.72461909
108GATA6_25053715_ChIP-Seq_YYC3_Human0.72280965
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.71130824
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.71123905
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70192689
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69929539
113* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69911455
114RACK7_27058665_Chip-Seq_MCF-7_Human0.69541469
115GATA2_21666600_ChIP-Seq_HMVEC_Human0.67893486
116* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67687201
117SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.66831187
118* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.66306478
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64274060
120* TBX20_22080862_ChIP-Seq_HEART_Mouse0.63745307
121* TBX20_22328084_ChIP-Seq_HEART_Mouse0.63745307
122* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.63706653
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.63107082
124* GATA1_19941827_ChIP-Seq_MEL_Mouse0.62877832
125* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.62517805
126* CEBPB_22108803_ChIP-Seq_LS180_Human0.62163974
127SCL_19346495_ChIP-Seq_HPC-7_Human0.61654164
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.61598811
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.60684296
130EGR1_19032775_ChIP-ChIP_M12_Human0.59371806
131SOX2_20726797_ChIP-Seq_SW620_Human0.59063574
132RARB_24833708_ChIP-Seq_LIVER_Mouse0.57159094
133ELK3_25401928_ChIP-Seq_HUVEC_Human0.56109140
134FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55787251
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.55374607
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.55374607
137* GATA3_24758297_ChIP-Seq_MCF-7_Human0.55184809
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.53171295
139ATF3_27146783_Chip-Seq_COLON_Human0.53160213
140BCOR_27268052_Chip-Seq_Bcells_Human0.52658258
141* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.52096442
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.51803659
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.51423678
144IRF8_27001747_Chip-Seq_BMDM_Mouse0.51106740
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.51047477
146RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.50553116
147E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.50533188
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.50037992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.44575695
2MP0005360_urolithiasis6.66774021
3MP0005365_abnormal_bile_salt5.57321092
4MP0005085_abnormal_gallbladder_physiolo5.48978755
5MP0008875_abnormal_xenobiotic_pharmacok4.33693075
6* MP0010329_abnormal_lipoprotein_level3.72322293
7MP0003806_abnormal_nucleotide_metabolis3.67758452
8MP0003252_abnormal_bile_duct3.50823171
9MP0009840_abnormal_foam_cell3.24324226
10MP0002877_abnormal_melanocyte_morpholog3.15089909
11MP0003191_abnormal_cellular_cholesterol2.81109020
12MP0005409_darkened_coat_color2.60934258
13MP0005083_abnormal_biliary_tract2.60100370
14MP0003566_abnormal_cell_adhesion2.55794719
15MP0001666_abnormal_nutrient_absorption2.53345262
16MP0005076_abnormal_cell_differentiation2.52339037
17MP0005332_abnormal_amino_acid2.48173874
18MP0005670_abnormal_white_adipose2.47904115
19* MP0002118_abnormal_lipid_homeostasis2.33988464
20* MP0000609_abnormal_liver_physiology2.26612646
21MP0010352_gastrointestinal_tract_polyps2.24529500
22MP0003195_calcinosis2.10391635
23MP0008260_abnormal_autophagy1.96862762
24MP0004130_abnormal_muscle_cell1.95599512
25MP0004233_abnormal_muscle_weight1.89739470
26MP0005319_abnormal_enzyme/_coenzyme1.82596202
27MP0005666_abnormal_adipose_tissue1.81144213
28MP0003705_abnormal_hypodermis_morpholog1.81094117
29MP0004019_abnormal_vitamin_homeostasis1.77939535
30MP0009780_abnormal_chondrocyte_physiolo1.72392439
31MP0005584_abnormal_enzyme/coenzyme_acti1.62525234
32MP0002138_abnormal_hepatobiliary_system1.53229410
33MP0003868_abnormal_feces_composition1.50788202
34MP0004185_abnormal_adipocyte_glucose1.50451253
35MP0001764_abnormal_homeostasis1.48806082
36MP0005501_abnormal_skin_physiology1.43560080
37MP0005257_abnormal_intraocular_pressure1.41856201
38MP0003186_abnormal_redox_activity1.40598712
39MP0001849_ear_inflammation1.36870999
40MP0003091_abnormal_cell_migration1.34256040
41MP0004272_abnormal_basement_membrane1.33876087
42MP0003950_abnormal_plasma_membrane1.33191195
43MP0009643_abnormal_urine_homeostasis1.32411665
44* MP0002971_abnormal_brown_adipose1.29911353
45MP0002254_reproductive_system_inflammat1.24832621
46MP0006138_congestive_heart_failure1.24192500
47MP0009697_abnormal_copulation1.21217144
48MP0000598_abnormal_liver_morphology1.20220307
49MP0003011_delayed_dark_adaptation1.18377318
50MP0005451_abnormal_body_composition1.15301573
51* MP0005334_abnormal_fat_pad1.14596075
52MP0001915_intracranial_hemorrhage1.13231296
53MP0003656_abnormal_erythrocyte_physiolo1.12869806
54MP0005375_adipose_tissue_phenotype1.12758707
55MP0001661_extended_life_span1.12016979
56MP0005647_abnormal_sex_gland1.09625929
57MP0001730_embryonic_growth_arrest1.08118576
58MP0001216_abnormal_epidermal_layer1.08091700
59MP0004381_abnormal_hair_follicle1.08077177
60MP0002098_abnormal_vibrissa_morphology1.07644404
61MP0000579_abnormal_nail_morphology1.07191596
62MP0009763_increased_sensitivity_to1.05983999
63MP0010678_abnormal_skin_adnexa1.04789826
64MP0000604_amyloidosis1.02558489
65MP0003690_abnormal_glial_cell0.99013594
66MP0010630_abnormal_cardiac_muscle0.97881158
67MP0009764_decreased_sensitivity_to0.96239185
68MP0006036_abnormal_mitochondrial_physio0.95686007
69MP0002089_abnormal_postnatal_growth/wei0.95293673
70MP0002896_abnormal_bone_mineralization0.94115618
71MP0000467_abnormal_esophagus_morphology0.93965444
72MP0004087_abnormal_muscle_fiber0.93636875
73MP0000678_abnormal_parathyroid_gland0.92184177
74* MP0002078_abnormal_glucose_homeostasis0.91878488
75MP0008469_abnormal_protein_level0.90745265
76MP0000747_muscle_weakness0.90632424
77MP0003941_abnormal_skin_development0.90048195
78MP0005535_abnormal_body_temperature0.89789440
79MP0005621_abnormal_cell_physiology0.89064750
80MP0010307_abnormal_tumor_latency0.88485401
81MP0000627_abnormal_mammary_gland0.88408582
82MP0000858_altered_metastatic_potential0.88331589
83MP0000377_abnormal_hair_follicle0.88238387
84MP0002876_abnormal_thyroid_physiology0.88195077
85MP0003724_increased_susceptibility_to0.86501629
86* MP0009115_abnormal_fat_cell0.86149718
87MP0002837_dystrophic_cardiac_calcinosis0.86038125
88MP0003172_abnormal_lysosome_physiology0.85031621
89MP0002086_abnormal_extraembryonic_tissu0.84205471
90MP0002269_muscular_atrophy0.83867246
91* MP0009642_abnormal_blood_homeostasis0.83830971
92MP0010368_abnormal_lymphatic_system0.82227527
93MP0003300_gastrointestinal_ulcer0.80479599
94MP0008438_abnormal_cutaneous_collagen0.80197671
95MP0003183_abnormal_peptide_metabolism0.79475976
96MP0010234_abnormal_vibrissa_follicle0.78892877
97MP0003111_abnormal_nucleus_morphology0.78877142
98MP0005636_abnormal_mineral_homeostasis0.77027652
99MP0004858_abnormal_nervous_system0.77021221
100MP0009765_abnormal_xenobiotic_induced0.76712101
101MP0002009_preneoplasia0.75889147
102MP0000762_abnormal_tongue_morphology0.75214057
103MP0003984_embryonic_growth_retardation0.75054509
104MP0005376_homeostasis/metabolism_phenot0.74746613
105MP0002796_impaired_skin_barrier0.74669771
106MP0009931_abnormal_skin_appearance0.74542889
107MP0001672_abnormal_embryogenesis/_devel0.74183533
108MP0005380_embryogenesis_phenotype0.74183533
109MP0000350_abnormal_cell_proliferation0.73792990
110* MP0002970_abnormal_white_adipose0.73323514
111* MP0005448_abnormal_energy_balance0.72719061
112MP0000462_abnormal_digestive_system0.72634217
113MP0005464_abnormal_platelet_physiology0.72479848
114MP0002088_abnormal_embryonic_growth/wei0.71810837
115MP0001756_abnormal_urination0.71073621
116MP0000759_abnormal_skeletal_muscle0.70518037
117MP0004808_abnormal_hematopoietic_stem0.70115543
118MP0000920_abnormal_myelination0.69465528
119MP0000733_abnormal_muscle_development0.67742408
120MP0002396_abnormal_hematopoietic_system0.66742567
121MP0005408_hypopigmentation0.63485127
122MP0005266_abnormal_metabolism0.62074659
123MP0003436_decreased_susceptibility_to0.61436094
124MP0005058_abnormal_lysosome_morphology0.61143639
125MP0001881_abnormal_mammary_gland0.60019681
126MP0002136_abnormal_kidney_physiology0.56756800
127MP0005167_abnormal_blood-brain_barrier0.55149415
128MP0002060_abnormal_skin_morphology0.52813404
129MP0005220_abnormal_exocrine_pancreas0.51793644
130MP0004782_abnormal_surfactant_physiolog0.51609901
131MP0003329_amyloid_beta_deposits0.51445754
132MP0000249_abnormal_blood_vessel0.51086840
133MP0000003_abnormal_adipose_tissue0.50334402
134MP0003075_altered_response_to0.49842563
135MP0005084_abnormal_gallbladder_morpholo0.48863192
136MP0005275_abnormal_skin_tensile0.48386804
137MP0004264_abnormal_extraembryonic_tissu0.47920418
138MP0002166_altered_tumor_susceptibility0.47352697
139MP0008873_increased_physiological_sensi0.45929140
140MP0003453_abnormal_keratinocyte_physiol0.45042373
141MP0001853_heart_inflammation0.44764673
142* MP0003953_abnormal_hormone_level0.44439786
143MP0009672_abnormal_birth_weight0.44343677
144MP0000639_abnormal_adrenal_gland0.41702958
145MP0005164_abnormal_response_to0.40436362
146MP0003638_abnormal_response/metabolism_0.40369932
147MP0005023_abnormal_wound_healing0.39382116
148MP0002168_other_aberrant_phenotype0.38997576
149MP0004147_increased_porphyrin_level0.38549277
150MP0001845_abnormal_inflammatory_respons0.38054323
151MP0006035_abnormal_mitochondrial_morpho0.38001769
152MP0005166_decreased_susceptibility_to0.37403508
153MP0004947_skin_inflammation0.36741160
154* MP0005452_abnormal_adipose_tissue0.35548267
155MP0008874_decreased_physiological_sensi0.34843993

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.56358421
2Intrahepatic cholestasis (HP:0001406)6.49633103
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.17797551
4Xanthomatosis (HP:0000991)6.00444339
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.65908130
6Hypobetalipoproteinemia (HP:0003563)5.63713131
7Complement deficiency (HP:0004431)5.35376228
8Prolonged partial thromboplastin time (HP:0003645)5.25143535
9Hyperlipoproteinemia (HP:0010980)5.21439529
10Hyperammonemia (HP:0001987)4.57549700
11Hypolipoproteinemia (HP:0010981)4.55208183
12Epidermoid cyst (HP:0200040)4.54349245
13Hyperglycinuria (HP:0003108)4.46201183
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.33284025
15Abnormality of serine family amino acid metabolism (HP:0010894)4.30971746
16Abnormality of glycine metabolism (HP:0010895)4.30971746
17Ketosis (HP:0001946)4.27758230
18Hyperglycinemia (HP:0002154)4.20890500
19Hypoalphalipoproteinemia (HP:0003233)4.20790706
20Joint hemorrhage (HP:0005261)4.16079649
21Hypoglycemic coma (HP:0001325)4.15402073
22Abnormality of the common coagulation pathway (HP:0010990)4.04980940
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.97793288
24Abnormality of complement system (HP:0005339)3.90488020
25Abnormality of fatty-acid metabolism (HP:0004359)3.68594180
26Fat malabsorption (HP:0002630)3.66316933
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.65465459
28Hypercholesterolemia (HP:0003124)3.64569745
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.64173094
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.50440329
31Abnormality of the intrinsic pathway (HP:0010989)3.40154265
32Abnormality of methionine metabolism (HP:0010901)3.35888268
33Myocardial infarction (HP:0001658)3.31485706
34Ketoacidosis (HP:0001993)3.22610881
35Conjugated hyperbilirubinemia (HP:0002908)3.02753326
36Hyperbilirubinemia (HP:0002904)2.92844067
37Asymmetry of the thorax (HP:0001555)2.90431008
38Skin nodule (HP:0200036)2.86735857
39Abnormality of pyrimidine metabolism (HP:0004353)2.81342399
40Protrusio acetabuli (HP:0003179)2.78977381
41Systemic lupus erythematosus (HP:0002725)2.78061847
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.78056329
43Dicarboxylic aciduria (HP:0003215)2.78056329
44Abnormality of nucleobase metabolism (HP:0010932)2.77966022
45Abnormality of serum amino acid levels (HP:0003112)2.77041398
46Abnormality of purine metabolism (HP:0004352)2.76277833
47Hepatocellular carcinoma (HP:0001402)2.71021076
48Flat acetabular roof (HP:0003180)2.70765732
49Delayed CNS myelination (HP:0002188)2.67030737
50Steatorrhea (HP:0002570)2.65365653
51Metabolic acidosis (HP:0001942)2.64774518
52Hypertriglyceridemia (HP:0002155)2.62359636
53Acanthocytosis (HP:0001927)2.59775516
54Spastic diplegia (HP:0001264)2.58873120
55Back pain (HP:0003418)2.58052385
56Vertebral compression fractures (HP:0002953)2.50770906
57Hemorrhage of the eye (HP:0011885)2.48862460
58Insidious onset (HP:0003587)2.47787681
59Termporal pattern (HP:0011008)2.47787681
60Abnormality of proline metabolism (HP:0010907)2.43172392
61Hydroxyprolinuria (HP:0003080)2.43172392
62Hyperacusis (HP:0010780)2.42084952
63Spontaneous abortion (HP:0005268)2.41392675
64Cerebral inclusion bodies (HP:0100314)2.40422692
65Hypoglycemic seizures (HP:0002173)2.37630539
66Pancreatitis (HP:0001733)2.36093489
67Lethargy (HP:0001254)2.34042613
68Esophageal varix (HP:0002040)2.33921422
69Amyloidosis (HP:0011034)2.32058992
70Abnormal gallbladder morphology (HP:0012437)2.29773258
71Ankyloglossia (HP:0010296)2.29594068
72Cholelithiasis (HP:0001081)2.28477119
73Recurrent gram-negative bacterial infections (HP:0005420)2.28232302
74Vascular calcification (HP:0004934)2.26624045
75Hypochromic microcytic anemia (HP:0004840)2.24704556
76Right ventricular cardiomyopathy (HP:0011663)2.21520789
77Dysmetric saccades (HP:0000641)2.21433722
78Gingival bleeding (HP:0000225)2.20071564
79Abnormal gallbladder physiology (HP:0012438)2.19729795
80Cholecystitis (HP:0001082)2.19729795
81Abnormal cartilage morphology (HP:0002763)2.19332760
82Glomerulonephritis (HP:0000099)2.18490868
83Myoglobinuria (HP:0002913)2.17694331
84Hyperparathyroidism (HP:0000843)2.16235111
85Malnutrition (HP:0004395)2.14461529
86Menorrhagia (HP:0000132)2.14015426
87Sensorimotor neuropathy (HP:0007141)2.12952934
88Generalized aminoaciduria (HP:0002909)2.12748047
89Cerebral aneurysm (HP:0004944)2.11178490
90Ulnar bowing (HP:0003031)2.09623859
91Late onset (HP:0003584)2.09040135
92Abnormality of the Achilles tendon (HP:0005109)2.08742510
93Cardiovascular calcification (HP:0011915)2.05374771
94Irritability (HP:0000737)2.05272427
95Brushfield spots (HP:0001088)2.03878764
96Neurofibrillary tangles (HP:0002185)2.03417239
97Gout (HP:0001997)2.02399713
98Insomnia (HP:0100785)2.00958725
99Abnormality of carpal bone ossification (HP:0006257)2.00648829
100Neonatal onset (HP:0003623)2.00192757
101Cerebral edema (HP:0002181)1.98867630
102Osteolytic defects of the hand bones (HP:0009699)1.97376677
103Osteolytic defects of the phalanges of the hand (HP:0009771)1.97376677
104Vomiting (HP:0002013)1.97220328
105Mitral stenosis (HP:0001718)1.97023292
106Achilles tendon contracture (HP:0001771)1.95749690
107Oligomenorrhea (HP:0000876)1.95227313
108Hyperinsulinemic hypoglycemia (HP:0000825)1.94676137
109Abnormality of iron homeostasis (HP:0011031)1.94234782
110Increased connective tissue (HP:0009025)1.94135109
111Abnormality of transition element cation homeostasis (HP:0011030)1.92016850
112Distal lower limb amyotrophy (HP:0008944)1.91863842
113Exercise-induced myalgia (HP:0003738)1.91734558
114Advanced eruption of teeth (HP:0006288)1.91103727
115Premature rupture of membranes (HP:0001788)1.90835396
116Polycythemia (HP:0001901)1.90452261
117Arterial tortuosity (HP:0005116)1.89707707
118Acanthosis nigricans (HP:0000956)1.88755703
119Nephritis (HP:0000123)1.87987389
120Nausea (HP:0002018)1.87114350
121Poikilocytosis (HP:0004447)1.86629668
122Increased mean platelet volume (HP:0011877)1.85986503
123Thrombophlebitis (HP:0004418)1.85925753
124Spinal cord lesions (HP:0100561)1.85620352
125Syringomyelia (HP:0003396)1.85620352
126Hyperglycemia (HP:0003074)1.85321449
127Rhabdomyolysis (HP:0003201)1.84788286
128Distal lower limb muscle weakness (HP:0009053)1.83625586
129Abnormality of the gallbladder (HP:0005264)1.82435204
130Pigmentary retinal degeneration (HP:0001146)1.82238701
131Elevated hepatic transaminases (HP:0002910)1.81715886
132Abnormality of the gastric mucosa (HP:0004295)1.81644406
133Abnormal ossification of hand bones (HP:0005921)1.81164116
134Thin bony cortex (HP:0002753)1.80138849
135J-shaped sella turcica (HP:0002680)1.78391011
136Neonatal death (HP:0003811)1.78049645
137Reticulocytosis (HP:0001923)1.77775274
138Abnormality of oral frenula (HP:0000190)1.75956859
139Abnormal tarsal ossification (HP:0008369)1.75605989
140Abnormal foot bone ossification (HP:0010675)1.74216106
141Wormian bones (HP:0002645)1.73682833
142Hypercortisolism (HP:0001578)1.73485280
143Abnormality of nail color (HP:0100643)1.73211824
144Vascular tortuosity (HP:0004948)1.71395701
145Centrally nucleated skeletal muscle fibers (HP:0003687)1.68434989
146Broad face (HP:0000283)1.66542119
147Microglossia (HP:0000171)1.66385340
148Abdominal distention (HP:0003270)1.63804516
149Vertebral arch anomaly (HP:0008438)1.63068624
150Relative macrocephaly (HP:0004482)1.61576644
151Increased variability in muscle fiber diameter (HP:0003557)1.60491901
152Macroorchidism (HP:0000053)1.59806782
153Multiple lipomas (HP:0001012)1.57920050
154Aneurysm (HP:0002617)1.56512871
155Decreased motor nerve conduction velocity (HP:0003431)1.55838828
156Septate vagina (HP:0001153)1.55046226
157Abnormality of the salivary glands (HP:0010286)1.54959405
158Upper limb amyotrophy (HP:0009129)1.52970197
159Distal upper limb amyotrophy (HP:0007149)1.52970197
160Atrioventricular block (HP:0001678)1.51944506
161Hyporeflexia of lower limbs (HP:0002600)1.51863221
162Subacute progressive viral hepatitis (HP:0006572)1.51106127
163Heterotopia (HP:0002282)1.50181862
164Bone pain (HP:0002653)1.49750126
165Spinal rigidity (HP:0003306)1.49666801
166Mitral regurgitation (HP:0001653)1.49422811
167Progressive external ophthalmoplegia (HP:0000590)1.49067574
168Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.48584464
169Abnormality of glycolysis (HP:0004366)1.48434231
170Micronodular cirrhosis (HP:0001413)1.48230361
171Overlapping toe (HP:0001845)1.48168793
172Abnormality of skeletal muscle fiber size (HP:0012084)1.47818814
173Hammertoe (HP:0001765)1.47468970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.59554924
2SIK14.17346852
3TRIB33.88318664
4ERN13.87488153
5PRPF4B3.19460161
6FGFR43.18955267
7PKN22.97078816
8LATS22.89743777
9CAMK1D2.86485228
10CDK122.83095054
11SMG12.80616157
12MST1R2.46276297
13SCYL22.25670803
14TAOK32.20622683
15INSRR1.97538594
16FLT31.94935000
17CAMK1G1.93826125
18EPHA21.84784221
19PTK61.75150747
20EPHB11.69558662
21RIPK11.68013545
22FRK1.59869532
23FGFR21.59514532
24LATS11.52878773
25MAP2K31.47544433
26MAP3K101.46903542
27ERBB41.43370983
28MAPK111.41222917
29EIF2AK11.39948900
30TYK21.39298327
31PRKAA21.39265877
32RPS6KB21.31120524
33MET1.30195408
34NEK91.29579142
35TGFBR21.26531178
36MAP3K131.25644835
37CDK61.24490737
38PAK41.23569750
39JAK21.23525194
40PIK3CG1.21473206
41MAP3K71.18049643
42MAP2K41.14842610
43TIE11.10739350
44PDK31.08639005
45PDK41.08639005
46JAK11.07549106
47FGFR31.04960742
48MAP3K91.04375366
49EEF2K1.03546885
50MAP4K11.00242820
51NEK60.99023014
52TBK10.96556593
53ARAF0.95740750
54GRK60.93693182
55LRRK20.89769702
56KDR0.86419967
57KSR10.83119366
58LMTK20.82208974
59TAOK20.82160794
60MAP3K30.81133918
61ABL20.79842514
62CDK40.79548549
63CSK0.79517712
64GSK3A0.78250288
65TTN0.77372331
66TESK10.75513627
67PDPK10.75089721
68MAP3K80.74715866
69NTRK10.74416681
70CSF1R0.72192301
71DAPK20.71274453
72PRKAA10.70426711
73STK380.69516463
74DMPK0.69473077
75PDGFRB0.69390438
76PRKG20.69065142
77AKT20.68867979
78PDK20.68614242
79PBK0.68404136
80MELK0.68281070
81CDK70.68030368
82RET0.67853338
83PIK3CA0.67448153
84PDGFRA0.67329060
85TRPM70.66571956
86MTOR0.66554792
87STK38L0.66149662
88MAPK40.65421670
89TYRO30.65096689
90PRKD30.64810292
91BMX0.64117646
92MAPK120.63686464
93MAP3K110.63677981
94JAK30.62977417
95DDR20.62056778
96CDK90.61587891
97PDK10.59284421
98PRKACG0.58778200
99BRD40.58550050
100STK30.57681978
101TTK0.57194158
102ICK0.57054437
103MAPKAPK30.56006362
104EPHA30.55255471
105YES10.53172321
106SIK30.53128653
107BRAF0.51894525
108RPS6KB10.51860957
109NME20.50164344
110SGK30.50056152
111RAF10.49336416
112ERBB20.49333303
113PINK10.49224743
114ALK0.48995023
115ZAP700.48957693
116MAP2K10.48266768
117IGF1R0.47360032
118STK240.46322462
119KIT0.46267516
120MAPK100.44518491
121RPS6KA20.44397380
122MAP3K140.44171726
123MAP3K20.43955547
124PTK20.43075557
125ILK0.41843465
126MAP2K20.41606021
127PRKD10.41593631
128STK100.41247074
129BTK0.41163459
130WNK10.39245223
131MAP3K60.38972715
132CSNK1G10.37338309
133FGFR10.37308931
134NEK20.36670457
135MOS0.35817241
136CDC42BPA0.35422060
137PRKCZ0.34796749
138DYRK1B0.34038779
139PAK20.32853864
140CLK10.32610835
141MAP2K60.32390991
142ITK0.32064061
143PRKCQ0.31683294
144IKBKE0.31555614
145IRAK30.31405642
146KSR20.31037762
147EGFR0.30452029
148PRKCH0.30353318
149MAP3K10.29708189
150MARK20.29402958

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.98483976
2Nitrogen metabolism_Homo sapiens_hsa009103.80571501
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05695350
4Fatty acid degradation_Homo sapiens_hsa000712.81358717
5Arginine biosynthesis_Homo sapiens_hsa002202.76367505
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74970009
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.67731324
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61153045
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60651966
10Tryptophan metabolism_Homo sapiens_hsa003802.53351481
11Propanoate metabolism_Homo sapiens_hsa006402.49592778
12Complement and coagulation cascades_Homo sapiens_hsa046102.46080660
13PPAR signaling pathway_Homo sapiens_hsa033202.41903433
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26979516
15Fatty acid metabolism_Homo sapiens_hsa012122.25387521
16Butanoate metabolism_Homo sapiens_hsa006502.06619156
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06006492
18Peroxisome_Homo sapiens_hsa041462.05935828
19Caffeine metabolism_Homo sapiens_hsa002322.05145135
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94178542
21beta-Alanine metabolism_Homo sapiens_hsa004101.86103590
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84683913
23Histidine metabolism_Homo sapiens_hsa003401.78444667
24Staphylococcus aureus infection_Homo sapiens_hsa051501.75722386
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72475481
26Chemical carcinogenesis_Homo sapiens_hsa052041.72351629
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64465534
28Chronic myeloid leukemia_Homo sapiens_hsa052201.64409746
29Pyruvate metabolism_Homo sapiens_hsa006201.59019234
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.54632251
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.53943534
32Thyroid cancer_Homo sapiens_hsa052161.53221893
33Fat digestion and absorption_Homo sapiens_hsa049751.52967364
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50031202
35Retinol metabolism_Homo sapiens_hsa008301.49820916
36Fatty acid elongation_Homo sapiens_hsa000621.46931950
37Phenylalanine metabolism_Homo sapiens_hsa003601.41797788
38Non-small cell lung cancer_Homo sapiens_hsa052231.40195617
39Bile secretion_Homo sapiens_hsa049761.39306962
40Selenocompound metabolism_Homo sapiens_hsa004501.38251702
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37998834
42Carbon metabolism_Homo sapiens_hsa012001.35607919
43Starch and sucrose metabolism_Homo sapiens_hsa005001.35493127
44Other glycan degradation_Homo sapiens_hsa005111.34475468
45Fatty acid biosynthesis_Homo sapiens_hsa000611.33937833
46Sulfur metabolism_Homo sapiens_hsa009201.32586282
47Tyrosine metabolism_Homo sapiens_hsa003501.31016138
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26679109
49ABC transporters_Homo sapiens_hsa020101.26326523
50Endometrial cancer_Homo sapiens_hsa052131.26074425
51Pancreatic cancer_Homo sapiens_hsa052121.22953661
52Renal cell carcinoma_Homo sapiens_hsa052111.20029004
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18097450
54Biosynthesis of amino acids_Homo sapiens_hsa012301.17646054
55Folate biosynthesis_Homo sapiens_hsa007901.13243585
56Glycerolipid metabolism_Homo sapiens_hsa005611.11503612
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09524728
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08130217
59Glioma_Homo sapiens_hsa052141.08086607
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.06870973
61VEGF signaling pathway_Homo sapiens_hsa043701.04814796
62Adherens junction_Homo sapiens_hsa045201.01462866
63Bladder cancer_Homo sapiens_hsa052191.00264101
64ErbB signaling pathway_Homo sapiens_hsa040120.99781813
65Vitamin B6 metabolism_Homo sapiens_hsa007500.98362325
66Small cell lung cancer_Homo sapiens_hsa052220.96584749
67Sulfur relay system_Homo sapiens_hsa041220.96571839
68mTOR signaling pathway_Homo sapiens_hsa041500.95274782
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94977344
70Inositol phosphate metabolism_Homo sapiens_hsa005620.93374993
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93171758
72Lysine degradation_Homo sapiens_hsa003100.91222996
73Steroid biosynthesis_Homo sapiens_hsa001000.91079280
74Proteoglycans in cancer_Homo sapiens_hsa052050.87981271
75Focal adhesion_Homo sapiens_hsa045100.87396354
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86063332
77Prostate cancer_Homo sapiens_hsa052150.81883747
78Estrogen signaling pathway_Homo sapiens_hsa049150.81808335
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81217526
80Vitamin digestion and absorption_Homo sapiens_hsa049770.81203485
81Arginine and proline metabolism_Homo sapiens_hsa003300.80174712
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79736574
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79729060
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78440444
85Pentose phosphate pathway_Homo sapiens_hsa000300.74815809
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74537017
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.74175845
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.73788412
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.71916532
90Long-term potentiation_Homo sapiens_hsa047200.69005170
91MicroRNAs in cancer_Homo sapiens_hsa052060.67782788
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67494146
93Glutathione metabolism_Homo sapiens_hsa004800.65383995
94ECM-receptor interaction_Homo sapiens_hsa045120.64877356
95Choline metabolism in cancer_Homo sapiens_hsa052310.63736109
96Sphingolipid metabolism_Homo sapiens_hsa006000.63048517
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.62172013
98Prolactin signaling pathway_Homo sapiens_hsa049170.60126016
99HIF-1 signaling pathway_Homo sapiens_hsa040660.59085963
100GnRH signaling pathway_Homo sapiens_hsa049120.58771271
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56898296
102* Adipocytokine signaling pathway_Homo sapiens_hsa049200.54701989
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.52908565
104Insulin resistance_Homo sapiens_hsa049310.52850381
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50451117
106One carbon pool by folate_Homo sapiens_hsa006700.49871041
107B cell receptor signaling pathway_Homo sapiens_hsa046620.49274410
108FoxO signaling pathway_Homo sapiens_hsa040680.47567961
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39943217
110Metabolic pathways_Homo sapiens_hsa011000.38742463
111Galactose metabolism_Homo sapiens_hsa000520.35414805
112* AMPK signaling pathway_Homo sapiens_hsa041520.35337908
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35176125
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34102071
115Fructose and mannose metabolism_Homo sapiens_hsa000510.32411842
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.29084716
117Prion diseases_Homo sapiens_hsa050200.25091606
118Linoleic acid metabolism_Homo sapiens_hsa005910.23676820
119Glucagon signaling pathway_Homo sapiens_hsa049220.22359413
120Insulin signaling pathway_Homo sapiens_hsa049100.14507376
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13256854
122Renin-angiotensin system_Homo sapiens_hsa046140.05388528
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.04316048
124Pertussis_Homo sapiens_hsa05133-0.1628139
125Type II diabetes mellitus_Homo sapiens_hsa04930-0.1618325
126Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1589930
127Lysosome_Homo sapiens_hsa04142-0.1500759
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1392652
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1321126
130Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1294952
131Protein digestion and absorption_Homo sapiens_hsa04974-0.1249033
132Acute myeloid leukemia_Homo sapiens_hsa05221-0.1224548
133* Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1219896
134Amoebiasis_Homo sapiens_hsa05146-0.1018923
135Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0960375
136Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0869198
137Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0762326
138Hepatitis C_Homo sapiens_hsa05160-0.0723928
139* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0708398
140Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0623159

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