ADIRF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: APM2 gene is exclusively expressed in adipose tissue. Its function is currently unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)6.86431209
2NADH metabolic process (GO:0006734)6.04397695
3triglyceride catabolic process (GO:0019433)5.82688359
4transcytosis (GO:0045056)5.25627683
5acylglycerol catabolic process (GO:0046464)5.13788829
6neutral lipid catabolic process (GO:0046461)5.13788829
7regulation of sequestering of triglyceride (GO:0010889)4.96758259
8diacylglycerol metabolic process (GO:0046339)4.70719481
9barbed-end actin filament capping (GO:0051016)4.54456151
10positive regulation of triglyceride lipase activity (GO:0061365)4.25502479
11positive regulation of lipoprotein lipase activity (GO:0051006)4.25502479
12angiotensin maturation (GO:0002003)4.15019964
13lipid storage (GO:0019915)3.94378848
14ethanol oxidation (GO:0006069)3.79234513
15extracellular fibril organization (GO:0043206)3.67894377
16regulation of cholesterol storage (GO:0010885)3.59631969
17glycerolipid catabolic process (GO:0046503)3.52789880
18virion attachment to host cell (GO:0019062)3.50418000
19adhesion of symbiont to host cell (GO:0044650)3.50418000
20lipoprotein transport (GO:0042953)3.49150288
21triglyceride biosynthetic process (GO:0019432)3.48011139
22fibril organization (GO:0097435)3.43916536
23acylglycerol biosynthetic process (GO:0046463)3.40458564
24neutral lipid biosynthetic process (GO:0046460)3.40458564
25protein heterotrimerization (GO:0070208)3.37594214
26cellular response to cadmium ion (GO:0071276)3.36350682
27response to phenylpropanoid (GO:0080184)3.31965637
28cGMP-mediated signaling (GO:0019934)3.30901420
29keratan sulfate catabolic process (GO:0042340)3.27235045
30primary alcohol metabolic process (GO:0034308)3.26168180
31triglyceride metabolic process (GO:0006641)3.24959402
32white fat cell differentiation (GO:0050872)3.22209880
33polyol transport (GO:0015791)3.21551388
34response to dietary excess (GO:0002021)3.19887415
35oxaloacetate metabolic process (GO:0006107)3.19273292
36brown fat cell differentiation (GO:0050873)3.13981230
37ovulation from ovarian follicle (GO:0001542)3.12865253
38fructose metabolic process (GO:0006000)3.12834710
39ethanol metabolic process (GO:0006067)3.11743837
40adhesion of symbiont to host (GO:0044406)3.10549964
41fatty acid homeostasis (GO:0055089)3.08285271
42lipid particle organization (GO:0034389)3.05726072
43acylglycerol metabolic process (GO:0006639)3.03133653
44negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.02685153
45CDP-diacylglycerol metabolic process (GO:0046341)3.02635240
46negative regulation of smooth muscle cell migration (GO:0014912)3.01820702
47glomerular filtration (GO:0003094)3.01441207
48endocrine hormone secretion (GO:0060986)3.01365365
49CDP-diacylglycerol biosynthetic process (GO:0016024)3.00940596
50negative regulation of metanephros development (GO:0072217)2.99191311
51neutral lipid metabolic process (GO:0006638)2.97151197
52regulation of metalloenzyme activity (GO:0048552)2.95062369
53negative regulation of smooth muscle cell proliferation (GO:0048662)2.92988630
54primary alcohol catabolic process (GO:0034310)2.92506660
55regulation of gonadotropin secretion (GO:0032276)2.92420935
56cellular response to zinc ion (GO:0071294)2.91814551
57positive regulation of cellular response to insulin stimulus (GO:1900078)2.91272223
58retinol metabolic process (GO:0042572)2.90075550
59membrane raft organization (GO:0031579)2.89897425
60regulation of receptor binding (GO:1900120)2.89001984
61renal filtration (GO:0097205)2.88323995
62negative regulation of protein autophosphorylation (GO:0031953)2.88145923
63protein localization to cell surface (GO:0034394)2.88091198
64negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.86922632
65retina vasculature morphogenesis in camera-type eye (GO:0061299)2.85708250
66response to nitrosative stress (GO:0051409)2.85539520
67cellular response to vitamin (GO:0071295)2.85032120
68regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.82016718
69phosphatidic acid biosynthetic process (GO:0006654)2.80758293
70phosphatidic acid metabolic process (GO:0046473)2.80758293
71regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.80524429
72positive regulation of fatty acid metabolic process (GO:0045923)2.80112475
73regulation of lipoprotein metabolic process (GO:0050746)2.79769699
74regulation of macrophage derived foam cell differentiation (GO:0010743)2.78866272
75biotin metabolic process (GO:0006768)2.77397067
76positive regulation of pseudopodium assembly (GO:0031274)2.77339622
77fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.75692441
78plasma lipoprotein particle clearance (GO:0034381)2.75349267
79regulation of triglyceride catabolic process (GO:0010896)2.74521493
80negative regulation of amino acid transport (GO:0051956)2.71724339
81response to hydroperoxide (GO:0033194)2.70582973
82cellular response to lithium ion (GO:0071285)2.70207347
83positive regulation of glomerulus development (GO:0090193)2.69249237
84type B pancreatic cell proliferation (GO:0044342)2.67380607
85fatty acid catabolic process (GO:0009062)2.64885625
86negative regulation of granulocyte differentiation (GO:0030853)2.64722414
87fatty acid beta-oxidation (GO:0006635)2.58915564
88positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.58223241
89xenobiotic catabolic process (GO:0042178)2.58162288
90polyketide metabolic process (GO:0030638)2.57994059
91doxorubicin metabolic process (GO:0044598)2.57994059
92daunorubicin metabolic process (GO:0044597)2.57994059
93regulation of integrin-mediated signaling pathway (GO:2001044)2.57946485
94positive regulation of lipid catabolic process (GO:0050996)2.57405212
95negative regulation of nitric oxide biosynthetic process (GO:0045019)2.56669564
96positive regulation of lipid storage (GO:0010884)2.55653886
97urea cycle (GO:0000050)2.55248075
98glycerol metabolic process (GO:0006071)2.54839475
99negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.53456263
100endothelial cell chemotaxis (GO:0035767)2.50353176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.34851649
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.40826752
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.13296431
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.90605654
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.66045448
6CLOCK_20551151_ChIP-Seq_293T_Human2.89497149
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.83681337
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77737562
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.46920217
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.41414837
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.26860916
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.24810126
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.24254325
14ZNF263_19887448_ChIP-Seq_K562_Human2.11844520
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11485949
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.00867005
17LXR_22292898_ChIP-Seq_THP-1_Human1.91818817
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88076451
19LXR_22158963_ChIP-Seq_LIVER_Mouse1.78974570
20RACK7_27058665_Chip-Seq_MCF-7_Human1.77302702
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75603240
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.73844822
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72874993
24SOX2_20726797_ChIP-Seq_SW620_Human1.71053428
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68989462
26CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68603911
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66402322
28P63_26484246_Chip-Seq_KERATINOCYTES_Human1.61745281
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60142852
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58141314
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56266521
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55957515
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51772886
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51588907
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.49979239
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.49695505
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46590050
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46164303
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.45524136
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40723474
41TBX20_22328084_ChIP-Seq_HEART_Mouse1.39255179
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.39255179
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38965641
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36516266
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.35663655
46RAD21_21589869_ChIP-Seq_MESCs_Mouse1.30588593
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25877952
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23417938
49BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.22923388
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21707906
51CJUN_26792858_Chip-Seq_BT549_Human1.20768851
52ATF3_27146783_Chip-Seq_COLON_Human1.17547151
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.17297230
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15891667
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15891667
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14433914
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14409106
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14090079
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13869493
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10582616
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10041290
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08264930
63SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07736572
64CTCF_27219007_Chip-Seq_Bcells_Human1.06642533
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06618657
66CSB_26484114_Chip-Seq_FIBROBLAST_Human1.05860655
67TP63_22573176_ChIP-Seq_HFKS_Human1.04162798
68SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04128311
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.03634024
70SMC4_20622854_ChIP-Seq_HELA_Human1.03534026
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02021743
72PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02018787
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.01840717
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01493621
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01300645
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98869369
77P68_20966046_ChIP-Seq_HELA_Human0.98439716
78NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96352780
79GATA3_24758297_ChIP-Seq_MCF-7_Human0.95240973
80GATA4_25053715_ChIP-Seq_YYC3_Human0.95171068
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94872158
82STAT1_20625510_ChIP-Seq_HELA_Human0.94716280
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93382332
84CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93117678
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92944914
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.92536397
87SA1_27219007_Chip-Seq_ERYTHROID_Human0.91979787
88PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91431427
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91356777
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90831309
91BCL6_27268052_Chip-Seq_Bcells_Human0.90513694
92SA1_27219007_Chip-Seq_Bcells_Human0.90154764
93BCOR_27268052_Chip-Seq_Bcells_Human0.89119896
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88929391
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88217458
96SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87687538
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85488806
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85218896
99CBP_21632823_ChIP-Seq_H3396_Human0.83981970
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83417682

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.39895249
2MP0005666_abnormal_adipose_tissue4.28302506
3MP0005360_urolithiasis3.41444827
4MP0004185_abnormal_adipocyte_glucose3.18552311
5MP0005375_adipose_tissue_phenotype3.08118045
6MP0002971_abnormal_brown_adipose3.00120574
7MP0005275_abnormal_skin_tensile2.67485420
8MP0003705_abnormal_hypodermis_morpholog2.55454081
9MP0005503_abnormal_tendon_morphology2.53351335
10MP0004130_abnormal_muscle_cell2.43077595
11MP0003191_abnormal_cellular_cholesterol2.37386789
12MP0009115_abnormal_fat_cell2.30427719
13MP0008438_abnormal_cutaneous_collagen2.27579015
14MP0003011_delayed_dark_adaptation2.24889004
15MP0009780_abnormal_chondrocyte_physiolo2.21814960
16MP0010329_abnormal_lipoprotein_level2.05690800
17MP0003724_increased_susceptibility_to2.03927132
18MP0002876_abnormal_thyroid_physiology1.97260154
19MP0006138_congestive_heart_failure1.88524366
20MP0000751_myopathy1.82779299
21MP0003950_abnormal_plasma_membrane1.74711359
22MP0004272_abnormal_basement_membrane1.74234844
23MP0010234_abnormal_vibrissa_follicle1.73677788
24MP0000003_abnormal_adipose_tissue1.73335650
25MP0004019_abnormal_vitamin_homeostasis1.72079474
26MP0002970_abnormal_white_adipose1.71236539
27MP0005535_abnormal_body_temperature1.69347044
28MP0005334_abnormal_fat_pad1.68082755
29MP0003828_pulmonary_edema1.65953402
30MP0002796_impaired_skin_barrier1.63017793
31MP0005365_abnormal_bile_salt1.60468263
32MP0009840_abnormal_foam_cell1.56892995
33MP0003186_abnormal_redox_activity1.56830137
34MP0003959_abnormal_lean_body1.54676816
35MP0000343_altered_response_to1.49399820
36MP0010368_abnormal_lymphatic_system1.48860526
37MP0002118_abnormal_lipid_homeostasis1.47924819
38MP0001958_emphysema1.42927515
39MP0003868_abnormal_feces_composition1.38463624
40MP0003806_abnormal_nucleotide_metabolis1.37582981
41MP0002108_abnormal_muscle_morphology1.31676037
42MP0000013_abnormal_adipose_tissue1.30346487
43MP0003279_aneurysm1.29296356
44MP0005448_abnormal_energy_balance1.29001741
45MP0005165_increased_susceptibility_to1.25786658
46MP0003075_altered_response_to1.24364794
47MP0005058_abnormal_lysosome_morphology1.24153820
48MP0001879_abnormal_lymphatic_vessel1.22534438
49MP0005167_abnormal_blood-brain_barrier1.18090613
50MP0009643_abnormal_urine_homeostasis1.16373547
51MP0002933_joint_inflammation1.15578442
52MP0001764_abnormal_homeostasis1.13918930
53MP0000749_muscle_degeneration1.13650728
54MP0000249_abnormal_blood_vessel1.09106478
55MP0001881_abnormal_mammary_gland1.09055178
56MP0005595_abnormal_vascular_smooth1.06503200
57MP0005164_abnormal_response_to1.06229489
58MP0001661_extended_life_span1.06210105
59MP0002295_abnormal_pulmonary_circulatio1.01749278
60MP0001542_abnormal_bone_strength1.00273137
61MP0003879_abnormal_hair_cell0.99558821
62MP0005452_abnormal_adipose_tissue0.96867777
63MP0002060_abnormal_skin_morphology0.95431995
64MP0002139_abnormal_hepatobiliary_system0.94500572
65MP0000858_altered_metastatic_potential0.94422212
66MP0000750_abnormal_muscle_regeneration0.93103866
67MP0005385_cardiovascular_system_phenoty0.92694924
68MP0001544_abnormal_cardiovascular_syste0.92694924
69MP0008775_abnormal_heart_ventricle0.90538791
70MP0004858_abnormal_nervous_system0.90086152
71MP0005023_abnormal_wound_healing0.89670174
72MP0005584_abnormal_enzyme/coenzyme_acti0.88758546
73MP0009379_abnormal_foot_pigmentation0.88591715
74MP0001501_abnormal_sleep_pattern0.85420260
75MP0000609_abnormal_liver_physiology0.84555373
76MP0003453_abnormal_keratinocyte_physiol0.84261174
77MP0005166_decreased_susceptibility_to0.83809507
78MP0001666_abnormal_nutrient_absorption0.83055729
79MP0000230_abnormal_systemic_arterial0.81785341
80MP0001756_abnormal_urination0.81637953
81MP0002078_abnormal_glucose_homeostasis0.81305593
82MP0006036_abnormal_mitochondrial_physio0.81169907
83MP0005257_abnormal_intraocular_pressure0.80942344
84MP0003566_abnormal_cell_adhesion0.80926117
85MP0005085_abnormal_gallbladder_physiolo0.80811487
86MP0004087_abnormal_muscle_fiber0.78744571
87MP0001533_abnormal_skeleton_physiology0.78519949
88MP0000759_abnormal_skeletal_muscle0.78328287
89MP0002909_abnormal_adrenal_gland0.77909861
90MP0005501_abnormal_skin_physiology0.76951885
91MP0000767_abnormal_smooth_muscle0.73953280
92MP0005330_cardiomyopathy0.73949676
93MP0002166_altered_tumor_susceptibility0.73663938
94MP0003690_abnormal_glial_cell0.73489416
95MP0004782_abnormal_surfactant_physiolog0.72474995
96MP0005409_darkened_coat_color0.71117023
97MP0005647_abnormal_sex_gland0.70308907
98MP0002332_abnormal_exercise_endurance0.68931251
99MP0002972_abnormal_cardiac_muscle0.68725584
100MP0000747_muscle_weakness0.68483411

Predicted human phenotypes

RankGene SetZ-score
1Acanthosis nigricans (HP:0000956)5.71004494
2Hypertriglyceridemia (HP:0002155)4.81374918
3Oligomenorrhea (HP:0000876)4.64004454
4Systemic lupus erythematosus (HP:0002725)3.96207046
5Axonal loss (HP:0003447)3.93748803
6Growth hormone excess (HP:0000845)3.83764171
7Reduced subcutaneous adipose tissue (HP:0003758)3.80964465
8Protrusio acetabuli (HP:0003179)3.74660259
9Complement deficiency (HP:0004431)3.57088889
10Abnormality of complement system (HP:0005339)3.50381294
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.44686282
12Insulin resistance (HP:0000855)3.43113149
13Bone cyst (HP:0012062)3.26221246
14Ileus (HP:0002595)3.26047870
15Amyloidosis (HP:0011034)3.17547928
16Aortic aneurysm (HP:0004942)3.12855864
17Vertebral compression fractures (HP:0002953)3.07763832
18Pigmentary retinal degeneration (HP:0001146)3.01015895
19Increased variability in muscle fiber diameter (HP:0003557)2.95425167
20Nausea (HP:0002018)2.92565531
21Increased connective tissue (HP:0009025)2.87661231
22Insulin-resistant diabetes mellitus (HP:0000831)2.85144282
23Malnutrition (HP:0004395)2.83216716
24Spinal rigidity (HP:0003306)2.80588729
25Hemorrhage of the eye (HP:0011885)2.80083512
26Osteolytic defects of the hand bones (HP:0009699)2.72681652
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.72681652
28Glucose intolerance (HP:0000833)2.62998850
29Colitis (HP:0002583)2.62032940
30Xanthomatosis (HP:0000991)2.60877332
31Hydroxyprolinuria (HP:0003080)2.58181408
32Abnormality of proline metabolism (HP:0010907)2.58181408
33Premature rupture of membranes (HP:0001788)2.55249890
34Abnormal glucose tolerance (HP:0001952)2.46031693
35Fat malabsorption (HP:0002630)2.44260221
36Abnormality of skeletal muscle fiber size (HP:0012084)2.44013682
37Skin nodule (HP:0200036)2.43180528
38Right ventricular cardiomyopathy (HP:0011663)2.40674447
39Myocardial infarction (HP:0001658)2.39427937
40Increased muscle lipid content (HP:0009058)2.38312433
41Subcapsular cataract (HP:0000523)2.38262487
42Neck muscle weakness (HP:0000467)2.36080596
43Steatorrhea (HP:0002570)2.29659763
44Cervical subluxation (HP:0003308)2.27043671
45Glomerulonephritis (HP:0000099)2.26250652
46Multiple lipomas (HP:0001012)2.24520624
47Bulbar palsy (HP:0001283)2.24275391
48Polygenic inheritance (HP:0010982)2.20617113
49Hypercortisolism (HP:0001578)2.15397552
50Polar cataract (HP:0010696)2.15383061
51Wide cranial sutures (HP:0010537)2.15325445
52Muscle fiber splitting (HP:0003555)2.14584410
53Distal lower limb muscle weakness (HP:0009053)2.12707426
54Hyperparathyroidism (HP:0000843)2.12050008
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.07754711
56Short nail (HP:0001799)2.07531023
57Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03425576
58Delayed CNS myelination (HP:0002188)2.01658505
59Joint stiffness (HP:0001387)2.00526072
60Wormian bones (HP:0002645)2.00518628
61Spinal cord compression (HP:0002176)1.97895323
62Thin bony cortex (HP:0002753)1.97373013
63Abnormality of carpal bone ossification (HP:0006257)1.96257252
64Vascular tortuosity (HP:0004948)1.95597229
65Back pain (HP:0003418)1.95005755
66Abnormality of the nasal mucosa (HP:0000433)1.94571396
67Lipoatrophy (HP:0100578)1.94185147
68Hyperlipoproteinemia (HP:0010980)1.93833443
69Nuclear cataract (HP:0100018)1.92877505
70Hyporeflexia of lower limbs (HP:0002600)1.92593113
71Abnormality of the costochondral junction (HP:0000919)1.92493875
72Hypercholesterolemia (HP:0003124)1.91702185
73Nephritis (HP:0000123)1.88738528
74Abnormal hemoglobin (HP:0011902)1.88679935
75Ectopia lentis (HP:0001083)1.87105079
76Abnormal eating behavior (HP:0100738)1.86591231
77Mildly elevated creatine phosphokinase (HP:0008180)1.85623500
78Dysostosis multiplex (HP:0000943)1.83079993
79Pulmonary artery stenosis (HP:0004415)1.82075219
80Epidermoid cyst (HP:0200040)1.80790835
81Confusion (HP:0001289)1.78113002
82Gastrointestinal dysmotility (HP:0002579)1.76705566
83Hypoalphalipoproteinemia (HP:0003233)1.75891305
84Foot dorsiflexor weakness (HP:0009027)1.75694229
85Increased serum pyruvate (HP:0003542)1.75357982
86Segmental peripheral demyelination/remyelination (HP:0003481)1.74053960
87Alopecia of scalp (HP:0002293)1.73141458
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72837785
89Abnormality of glycolipid metabolism (HP:0010969)1.72454407
90Abnormality of liposaccharide metabolism (HP:0010968)1.72454407
91Abnormality of glycosphingolipid metabolism (HP:0004343)1.72454407
92Emphysema (HP:0002097)1.72139649
93Widely patent fontanelles and sutures (HP:0004492)1.71764343
94Metaphyseal dysplasia (HP:0100255)1.71394937
95Broad metatarsal (HP:0001783)1.71381143
96Asymmetric septal hypertrophy (HP:0001670)1.71239425
97Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69605829
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.69605829
99Shallow orbits (HP:0000586)1.68708781
100Rhabdomyolysis (HP:0003201)1.68166298

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.19609443
2MST1R3.90939568
3MYLK3.43200217
4NME23.39985722
5ARAF3.29627029
6ERN13.22843136
7EPHA23.19755460
8EPHB23.13875954
9RIPK13.03957156
10TRIB32.83827882
11DDR22.61141560
12TGFBR22.34393879
13PIM22.17893708
14ABL22.06001765
15MAPKAPK32.01145528
16GRK52.00164970
17TIE11.97039971
18SIK11.74572679
19MET1.72266793
20TESK21.62749388
21LIMK11.53748277
22ILK1.41279078
23MOS1.41199948
24LATS21.36556018
25PAK41.20533782
26MAP3K121.19459732
27PDGFRA1.18296395
28LMTK21.11800624
29PTK21.11677839
30PRKAA21.09540615
31CAMK1D1.06101022
32FER1.05527676
33PRKG21.04450470
34MAP3K31.02285576
35DAPK31.00170154
36IRAK30.95616537
37PINK10.95424382
38TAOK10.92744504
39LRRK20.88685387
40SCYL20.87823100
41MAP3K60.85965754
42LATS10.84056849
43MAP3K110.81113405
44BRAF0.80325376
45TBK10.79983778
46CDC42BPA0.79809244
47PRPF4B0.79629418
48BMX0.74910468
49CAMK10.74337016
50EEF2K0.73154913
51PDPK10.70093532
52TYK20.69813248
53PRKD20.67820121
54EPHB10.66924581
55TRPM70.64963727
56ACVR1B0.63575633
57CSK0.63345186
58MAPK40.60613521
59NEK90.60144206
60MAP3K10.59251104
61PAK10.57053708
62CAMK2G0.56709377
63RIPK40.56663137
64PTK60.55931874
65MST40.55850117
66GSK3A0.54668417
67KDR0.54136901
68PRKD10.51489112
69ADRBK10.51222363
70PAK20.51209020
71MUSK0.50834017
72MAPK120.49152287
73MAP2K10.48921095
74MAP3K130.48892887
75PTK2B0.47312645
76VRK20.46416506
77PRKCI0.45463904
78STK38L0.45461520
79PKN20.41888903
80CDK90.39173142
81PDGFRB0.38434833
82AKT30.38177010
83PRKACG0.37569799
84TAOK20.36179433
85STK380.35527089
86MAP3K20.34564925
87ROCK10.33193422
88MAPKAPK50.31885011
89PHKG10.30415290
90PHKG20.30415290
91AKT20.29488939
92DMPK0.29420257
93BCKDK0.27332007
94IGF1R0.26673555
95PRKG10.25189806
96ICK0.25095537
97MTOR0.24388877
98MAPK70.22996700
99HIPK20.22839461
100CDK60.22514329

Predicted pathways (KEGG)

RankGene SetZ-score
1PPAR signaling pathway_Homo sapiens_hsa033203.83182487
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.21815297
3Phenylalanine metabolism_Homo sapiens_hsa003603.20906753
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.05829733
5Fat digestion and absorption_Homo sapiens_hsa049752.89350459
6Histidine metabolism_Homo sapiens_hsa003402.63564595
7Renin-angiotensin system_Homo sapiens_hsa046142.62713666
8Glycerolipid metabolism_Homo sapiens_hsa005612.36748395
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.30772337
10Fatty acid elongation_Homo sapiens_hsa000622.27456854
11Vitamin digestion and absorption_Homo sapiens_hsa049772.25508887
12Fatty acid degradation_Homo sapiens_hsa000712.21048115
13Tyrosine metabolism_Homo sapiens_hsa003502.08805605
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05368008
15Pyruvate metabolism_Homo sapiens_hsa006201.99664453
16Fatty acid biosynthesis_Homo sapiens_hsa000611.98208879
17Glutathione metabolism_Homo sapiens_hsa004801.96432995
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91199869
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85374742
20Chemical carcinogenesis_Homo sapiens_hsa052041.81393968
21Sulfur metabolism_Homo sapiens_hsa009201.62054772
22Fructose and mannose metabolism_Homo sapiens_hsa000511.58593706
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55576859
24Tryptophan metabolism_Homo sapiens_hsa003801.53363437
25Mineral absorption_Homo sapiens_hsa049781.45325691
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.44018439
27Retinol metabolism_Homo sapiens_hsa008301.43684052
28Fatty acid metabolism_Homo sapiens_hsa012121.41888378
29Sulfur relay system_Homo sapiens_hsa041221.37009535
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34941008
31beta-Alanine metabolism_Homo sapiens_hsa004101.34111754
32Arachidonic acid metabolism_Homo sapiens_hsa005901.32531782
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31625647
34Arginine biosynthesis_Homo sapiens_hsa002201.31406848
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28830808
36AMPK signaling pathway_Homo sapiens_hsa041521.20739879
37Galactose metabolism_Homo sapiens_hsa000521.18379100
38Starch and sucrose metabolism_Homo sapiens_hsa005001.17214991
39Folate biosynthesis_Homo sapiens_hsa007901.15215163
40Protein digestion and absorption_Homo sapiens_hsa049741.12047997
41Propanoate metabolism_Homo sapiens_hsa006401.10694888
42Other glycan degradation_Homo sapiens_hsa005111.08797046
43Arginine and proline metabolism_Homo sapiens_hsa003301.04771504
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.99749688
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99468729
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90973104
47ECM-receptor interaction_Homo sapiens_hsa045120.90043242
48Complement and coagulation cascades_Homo sapiens_hsa046100.87792315
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87480069
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.87122413
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85216698
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.80959198
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.79463295
54Renin secretion_Homo sapiens_hsa049240.78701215
55Bile secretion_Homo sapiens_hsa049760.74195337
56Peroxisome_Homo sapiens_hsa041460.73269101
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.70443909
58Carbon metabolism_Homo sapiens_hsa012000.69632971
59Malaria_Homo sapiens_hsa051440.65658728
60Focal adhesion_Homo sapiens_hsa045100.65507821
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.63674247
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63582707
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62858351
64Pentose phosphate pathway_Homo sapiens_hsa000300.61442123
65Insulin signaling pathway_Homo sapiens_hsa049100.58355441
66Ovarian steroidogenesis_Homo sapiens_hsa049130.57447452
67Linoleic acid metabolism_Homo sapiens_hsa005910.55709785
68Insulin resistance_Homo sapiens_hsa049310.53299182
69Staphylococcus aureus infection_Homo sapiens_hsa051500.48039124
70Pertussis_Homo sapiens_hsa051330.46330270
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45289476
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43328934
73Alzheimers disease_Homo sapiens_hsa050100.40655847
74Glucagon signaling pathway_Homo sapiens_hsa049220.38619385
75Oxidative phosphorylation_Homo sapiens_hsa001900.37808782
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37405285
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33132638
78Proteoglycans in cancer_Homo sapiens_hsa052050.29468137
79Metabolic pathways_Homo sapiens_hsa011000.28490911
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27303618
81Lysosome_Homo sapiens_hsa041420.26223585
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25872766
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25357964
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23635473
85Parkinsons disease_Homo sapiens_hsa050120.22499745
86Caffeine metabolism_Homo sapiens_hsa002320.22478043
87Prion diseases_Homo sapiens_hsa050200.21257639
88Tight junction_Homo sapiens_hsa045300.21252363
89Sphingolipid metabolism_Homo sapiens_hsa006000.21129040
90Salivary secretion_Homo sapiens_hsa049700.20630110
91Butanoate metabolism_Homo sapiens_hsa006500.19857910
92Dilated cardiomyopathy_Homo sapiens_hsa054140.18374330
93Hepatitis C_Homo sapiens_hsa051600.17539924
94Endocytosis_Homo sapiens_hsa041440.16294786
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14986670
96Biosynthesis of amino acids_Homo sapiens_hsa012300.14814352
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.14491779
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.13065721
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12315540
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.11948395

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