ADK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.47885158
2L-phenylalanine catabolic process (GO:0006559)7.47885158
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.15792040
4L-phenylalanine metabolic process (GO:0006558)7.15792040
5aromatic amino acid family catabolic process (GO:0009074)6.59563629
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.03135628
7tryptophan catabolic process (GO:0006569)5.82817944
8indole-containing compound catabolic process (GO:0042436)5.82817944
9indolalkylamine catabolic process (GO:0046218)5.82817944
10bile acid biosynthetic process (GO:0006699)5.78724381
11proteasome assembly (GO:0043248)5.76134908
12glyoxylate metabolic process (GO:0046487)5.72908806
13kynurenine metabolic process (GO:0070189)5.72012403
14tryptophan metabolic process (GO:0006568)5.52286309
15cysteine metabolic process (GO:0006534)5.44860351
16alpha-linolenic acid metabolic process (GO:0036109)5.43519918
17urea cycle (GO:0000050)5.27315182
18urea metabolic process (GO:0019627)5.27315182
19negative regulation of fibrinolysis (GO:0051918)5.25448038
20high-density lipoprotein particle remodeling (GO:0034375)5.23049388
21sulfur amino acid catabolic process (GO:0000098)5.22072393
22regulation of protein activation cascade (GO:2000257)5.12361695
23peptidyl-glutamic acid carboxylation (GO:0017187)5.06952824
24protein carboxylation (GO:0018214)5.06952824
25complement activation, alternative pathway (GO:0006957)5.04105405
26regulation of fibrinolysis (GO:0051917)5.00443036
27lysine catabolic process (GO:0006554)5.00236691
28lysine metabolic process (GO:0006553)5.00236691
29serine family amino acid catabolic process (GO:0009071)4.97079549
30homocysteine metabolic process (GO:0050667)4.92359881
31bile acid metabolic process (GO:0008206)4.89561090
32nitrogen cycle metabolic process (GO:0071941)4.86808205
33regulation of complement activation (GO:0030449)4.79777164
34aromatic amino acid family metabolic process (GO:0009072)4.78419565
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.74314422
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.74284098
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.72020060
38alpha-amino acid catabolic process (GO:1901606)4.65420435
39regulation of triglyceride catabolic process (GO:0010896)4.63367134
40regulation of cholesterol esterification (GO:0010872)4.59871792
41reverse cholesterol transport (GO:0043691)4.59684765
42tyrosine metabolic process (GO:0006570)4.59656110
43protein-lipid complex remodeling (GO:0034368)4.58911282
44macromolecular complex remodeling (GO:0034367)4.58911282
45plasma lipoprotein particle remodeling (GO:0034369)4.58911282
46amino-acid betaine metabolic process (GO:0006577)4.58680763
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.50471577
48glycine metabolic process (GO:0006544)4.46532823
49cellular ketone body metabolic process (GO:0046950)4.42958935
50coenzyme catabolic process (GO:0009109)4.42717516
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.42632533
52acylglycerol homeostasis (GO:0055090)4.40042034
53triglyceride homeostasis (GO:0070328)4.40042034
54negative regulation of ligase activity (GO:0051352)4.33763933
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.33763933
56cellular glucuronidation (GO:0052695)4.33560339
57regulation of cellular amino acid metabolic process (GO:0006521)4.31950874
58cellular amino acid catabolic process (GO:0009063)4.31671323
59serine family amino acid metabolic process (GO:0009069)4.29593314
60serine family amino acid biosynthetic process (GO:0009070)4.28729125
61ribosome assembly (GO:0042255)4.25552798
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.24565586
63bile acid and bile salt transport (GO:0015721)4.22577564
64negative regulation of sterol transport (GO:0032372)4.20980162
65negative regulation of cholesterol transport (GO:0032375)4.20980162
66phospholipid efflux (GO:0033700)4.17835479
67cellular modified amino acid catabolic process (GO:0042219)4.14819926
68indolalkylamine metabolic process (GO:0006586)4.13089313
69imidazole-containing compound metabolic process (GO:0052803)4.12771283
70aldehyde catabolic process (GO:0046185)4.11710879
71glutamate metabolic process (GO:0006536)4.10873103
72cellular biogenic amine catabolic process (GO:0042402)4.10585378
73amine catabolic process (GO:0009310)4.10585378
74ethanol oxidation (GO:0006069)4.10349346
75plasma lipoprotein particle clearance (GO:0034381)4.07599633
76low-density lipoprotein particle remodeling (GO:0034374)4.04737741
77energy coupled proton transport, down electrochemical gradient (GO:0015985)3.99967294
78ATP synthesis coupled proton transport (GO:0015986)3.99967294
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.96467896
80benzene-containing compound metabolic process (GO:0042537)3.95033479
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.93064036
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.93064036
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.93064036
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.91534108
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.91534108
86cofactor catabolic process (GO:0051187)3.89701991
87regulation of mitochondrial translation (GO:0070129)3.89412130
88establishment of protein localization to mitochondrial membrane (GO:0090151)3.88961795
89cholesterol efflux (GO:0033344)3.88714091
90aspartate family amino acid catabolic process (GO:0009068)3.88102365
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.86242808
92arginine metabolic process (GO:0006525)3.85432920
93signal transduction involved in DNA damage checkpoint (GO:0072422)3.83479681
94signal transduction involved in DNA integrity checkpoint (GO:0072401)3.83479681
95glucuronate metabolic process (GO:0019585)3.83347069
96uronic acid metabolic process (GO:0006063)3.83347069
97short-chain fatty acid metabolic process (GO:0046459)3.83320149
98ketone body metabolic process (GO:1902224)3.81972594
99organic acid catabolic process (GO:0016054)3.81294726
100carboxylic acid catabolic process (GO:0046395)3.81294726
101dicarboxylic acid biosynthetic process (GO:0043650)3.79372716
102fibrinolysis (GO:0042730)3.79198541
103telomere maintenance via semi-conservative replication (GO:0032201)3.78909098
104signal transduction involved in cell cycle checkpoint (GO:0072395)3.75108547
105acetyl-CoA metabolic process (GO:0006084)3.74871778
106mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74558969
107plasma lipoprotein particle assembly (GO:0034377)3.73190978
108rRNA modification (GO:0000154)3.71756441
109positive regulation of ligase activity (GO:0051351)3.70731607
110drug catabolic process (GO:0042737)3.68177972
111cullin deneddylation (GO:0010388)3.66300084
112protein complex biogenesis (GO:0070271)3.66126815
113ribosomal large subunit biogenesis (GO:0042273)3.65099688
114complement activation, classical pathway (GO:0006958)3.64222454
115very-low-density lipoprotein particle assembly (GO:0034379)3.62799943
116blood coagulation, intrinsic pathway (GO:0007597)3.61736389
117establishment of integrated proviral latency (GO:0075713)3.61143337
118complement activation (GO:0006956)3.59352504
119mitochondrial respiratory chain complex assembly (GO:0033108)3.58526143
120chaperone-mediated protein transport (GO:0072321)3.58485841
121CENP-A containing nucleosome assembly (GO:0034080)3.57396409
1222-oxoglutarate metabolic process (GO:0006103)3.55536890
123positive regulation of triglyceride lipase activity (GO:0061365)3.55468491
124positive regulation of lipoprotein lipase activity (GO:0051006)3.55468491
125fatty acid beta-oxidation (GO:0006635)3.55200282
126cholesterol homeostasis (GO:0042632)3.55149999
127monocarboxylic acid catabolic process (GO:0072329)3.54743392
128protein activation cascade (GO:0072376)3.54092387
129fatty acid oxidation (GO:0019395)3.51683615
130positive regulation of lipid catabolic process (GO:0050996)3.51434602
131regulation of bile acid biosynthetic process (GO:0070857)3.49488227
132cytolysis (GO:0019835)3.48454518
133sterol homeostasis (GO:0055092)3.48452206
134lipid oxidation (GO:0034440)3.47541569
135intestinal cholesterol absorption (GO:0030299)3.47358202
136respiratory electron transport chain (GO:0022904)3.46107248
137DNA strand elongation involved in DNA replication (GO:0006271)3.44882169
138mitotic metaphase plate congression (GO:0007080)3.43894524
139regulation of ubiquitin-protein transferase activity (GO:0051438)3.41878634
140DNA replication checkpoint (GO:0000076)3.40676226
141water-soluble vitamin biosynthetic process (GO:0042364)3.40641287
142electron transport chain (GO:0022900)3.40230826
143mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38874609
144mitochondrial respiratory chain complex I assembly (GO:0032981)3.38874609
145NADH dehydrogenase complex assembly (GO:0010257)3.38874609
146purine nucleobase biosynthetic process (GO:0009113)3.37336287
147protein deneddylation (GO:0000338)3.36918002
148chromatin remodeling at centromere (GO:0031055)3.36628444
149DNA strand elongation (GO:0022616)3.33607151
150regulation of ligase activity (GO:0051340)3.30759957
151rRNA methylation (GO:0031167)3.30466463
152respiratory chain complex IV assembly (GO:0008535)3.25479484
153inner mitochondrial membrane organization (GO:0007007)3.24746688
154pseudouridine synthesis (GO:0001522)3.24267464
155telomere maintenance via recombination (GO:0000722)3.22635806
156metaphase plate congression (GO:0051310)3.17511614
157protein targeting to mitochondrion (GO:0006626)3.16575941
158branched-chain amino acid catabolic process (GO:0009083)3.15417590
159nucleobase-containing small molecule interconversion (GO:0015949)3.15240434
160regulation of cellular amine metabolic process (GO:0033238)3.13828650
161mitotic recombination (GO:0006312)3.10140310
162oxidative phosphorylation (GO:0006119)3.09479902
163pteridine-containing compound biosynthetic process (GO:0042559)3.09048803
164antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08917089
165DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.08876171
166nucleobase biosynthetic process (GO:0046112)3.06956398
167maturation of 5.8S rRNA (GO:0000460)3.06880491
168spliceosomal snRNP assembly (GO:0000387)3.06065127
169negative regulation of protein ubiquitination (GO:0031397)3.05130734
170cytochrome complex assembly (GO:0017004)3.04521485
171establishment of viral latency (GO:0019043)3.01921374
172transcription-coupled nucleotide-excision repair (GO:0006283)3.00915327
173positive regulation of cell cycle arrest (GO:0071158)3.00590446
174L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99221107
175tRNA aminoacylation (GO:0043039)2.99106414
176amino acid activation (GO:0043038)2.99106414
177cell cycle G1/S phase transition (GO:0044843)2.98932363
178G1/S transition of mitotic cell cycle (GO:0000082)2.98932363
179tricarboxylic acid cycle (GO:0006099)2.98576834
180formation of translation preinitiation complex (GO:0001731)2.97868275
181folic acid-containing compound biosynthetic process (GO:0009396)2.97829275
182termination of RNA polymerase III transcription (GO:0006386)2.96503614
183transcription elongation from RNA polymerase III promoter (GO:0006385)2.96503614
184tRNA aminoacylation for protein translation (GO:0006418)2.96060585
185nucleotide-excision repair, DNA gap filling (GO:0006297)2.95010124
186cellular component biogenesis (GO:0044085)2.92168177
187protein localization to mitochondrion (GO:0070585)2.90368611
188exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89498610
189establishment of protein localization to mitochondrion (GO:0072655)2.88396926
190translation (GO:0006412)2.88226201
191nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85421708
192antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.83522481
193negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.83414189
194ribosome biogenesis (GO:0042254)2.83157256
195DNA ligation (GO:0006266)2.83109922
196telomere maintenance via telomere lengthening (GO:0010833)2.82103710
197deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81455406
198tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81172250
199RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81172250
200ribonucleoprotein complex biogenesis (GO:0022613)2.78601990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.07718024
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.95479183
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.83569772
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.19153192
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.27387288
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.21232873
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.11094158
8E2F7_22180533_ChIP-Seq_HELA_Human5.02784639
9GABP_17652178_ChIP-ChIP_JURKAT_Human4.39546817
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.19753538
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.80063620
12* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.70239121
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68126808
14* MYC_18555785_ChIP-Seq_MESCs_Mouse3.53535877
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.29984278
16E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21157216
17ETS1_20019798_ChIP-Seq_JURKAT_Human3.02412752
18ELK1_19687146_ChIP-ChIP_HELA_Human2.96586805
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88751448
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.83577919
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77710408
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66326929
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61613877
24* VDR_23849224_ChIP-Seq_CD4+_Human2.57068605
25DCP1A_22483619_ChIP-Seq_HELA_Human2.56618463
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56508661
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49215440
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48072443
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46385781
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35927193
31FOXP3_21729870_ChIP-Seq_TREG_Human2.33397786
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.28213246
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18879104
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.14870251
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08826104
36GATA1_22025678_ChIP-Seq_K562_Human2.07580316
37MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04726863
38PADI4_21655091_ChIP-ChIP_MCF-7_Human2.03922731
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7936786
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.99516983
41* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95062374
42GABP_19822575_ChIP-Seq_HepG2_Human1.94638256
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.90737508
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87562308
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86098609
46XRN2_22483619_ChIP-Seq_HELA_Human1.83767958
47TTF2_22483619_ChIP-Seq_HELA_Human1.82335177
48CLOCK_20551151_ChIP-Seq_293T_Human1.74615473
49* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73526581
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.67772886
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64978344
52HTT_18923047_ChIP-ChIP_STHdh_Human1.61887498
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59551037
54* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59526585
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52847769
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48127565
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45142843
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43933273
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43753789
60* FOXA2_19822575_ChIP-Seq_HepG2_Human1.40569044
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39499874
62* KDM5A_27292631_Chip-Seq_BREAST_Human1.35657724
63* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34736417
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.32707783
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32302271
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32022230
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28852567
68* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27775166
69TFEB_21752829_ChIP-Seq_HELA_Human1.25846468
70* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25787768
71MYC_18940864_ChIP-ChIP_HL60_Human1.24942794
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23192962
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22660818
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19790942
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19539867
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17783988
77ELF5_23300383_ChIP-Seq_T47D_Human1.15600013
78RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14914917
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14826397
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14665501
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14189399
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10628673
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.05289027
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.05267989
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04247963
86* SOX17_20123909_ChIP-Seq_XEN_Mouse1.02194825
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02054775
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01403970
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00138546
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99930418
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98246894
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96983735
93SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96508525
94* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95229051
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93980114
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92797570
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92710966
98* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90796028
99GATA4_25053715_ChIP-Seq_YYC3_Human0.90530890
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88098073
101EWS_26573619_Chip-Seq_HEK293_Human0.87288844
102NOTCH1_21737748_ChIP-Seq_TLL_Human0.87062509
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86339454
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84936004
105AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83225775
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81207094
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79616569
108FUS_26573619_Chip-Seq_HEK293_Human0.78215622
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78106137
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76042807
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73269950
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73252075
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.72882169
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72764214
115* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.72109470
116RARA_24833708_ChIP-Seq_LIVER_Mouse0.71960222
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.71809546
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71347907
119PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70881021
120AR_20517297_ChIP-Seq_VCAP_Human0.70619060
121* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70017500
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69944528
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69750731
124* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69410618
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69109737
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67356590
127E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.67132916
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.66306952
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65285107
130* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64814757
131* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64814757
132* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62987757
133ZNF263_19887448_ChIP-Seq_K562_Human0.62038882
134IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.61139955
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60263209
136CEBPB_22108803_ChIP-Seq_LS180_Human0.59133070
137IRF8_22096565_ChIP-ChIP_GC-B_Human0.57287535
138RARB_24833708_ChIP-Seq_LIVER_Mouse0.56552804
139ESR1_21235772_ChIP-Seq_MCF-7_Human0.55211402
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54941214
141* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.54891937
142PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53838212
143ERG_20517297_ChIP-Seq_VCAP_Human0.51890324
144KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.51047623
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50878538
146P53_21459846_ChIP-Seq_SAOS-2_Human0.50577421
147* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.50446333
148PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49820286
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.49683594
150* CBP_21632823_ChIP-Seq_H3396_Human0.49500053
151MYC_19915707_ChIP-ChIP_AK7_Human0.49217277
152* ESET_19884257_ChIP-Seq_ESCs_Mouse0.48825048
153TAF2_19829295_ChIP-Seq_ESCs_Human0.48668250
154FOXA1_25552417_ChIP-Seq_VCAP_Human0.47032461
155* AR_21909140_ChIP-Seq_LNCAP_Human0.46827027
156GATA3_24758297_ChIP-Seq_MCF-7_Human0.45822542
157* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45606145
158POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.45579990
159ESR1_20079471_ChIP-ChIP_T-47D_Human0.45312594
160SOX2_20726797_ChIP-Seq_SW620_Human0.45015571
161TRIM28_21343339_ChIP-Seq_HEK293_Human0.44078265
162RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.43885120
163FOXH1_21741376_ChIP-Seq_EPCs_Human0.43232695
164STAT1_17558387_ChIP-Seq_HELA_Human0.42763841
165SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41562526
166* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.41422410
167NCOR_22424771_ChIP-Seq_293T_Human0.40568312
168GATA6_25053715_ChIP-Seq_YYC3_Human0.40367428
169OCT4_20526341_ChIP-Seq_ESCs_Human0.40304492
170GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.39963199
171SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38262121
172* EGR1_19032775_ChIP-ChIP_M12_Human0.38104261
173* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.36708195
174GATA2_19941826_ChIP-Seq_K562_Human0.36293686
175GATA1_19941826_ChIP-Seq_K562_Human0.36272540
176RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.36214152
177CDX2_22108803_ChIP-Seq_LS180_Human0.35926404
178IRF1_19129219_ChIP-ChIP_H3396_Human0.35241076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.17379455
2MP0005360_urolithiasis7.28962266
3MP0005085_abnormal_gallbladder_physiolo6.41951134
4MP0005365_abnormal_bile_salt6.15365460
5MP0008875_abnormal_xenobiotic_pharmacok4.92332238
6* MP0003806_abnormal_nucleotide_metabolis4.21644166
7MP0010094_abnormal_chromosome_stability3.95441591
8MP0003693_abnormal_embryo_hatching3.87186976
9MP0008058_abnormal_DNA_repair3.74264911
10MP0003252_abnormal_bile_duct3.69165612
11MP0004957_abnormal_blastocyst_morpholog3.50148623
12MP0010329_abnormal_lipoprotein_level3.42774255
13MP0005083_abnormal_biliary_tract3.42736231
14MP0009840_abnormal_foam_cell3.06208220
15MP0008007_abnormal_cellular_replicative2.96289709
16MP0005332_abnormal_amino_acid2.93406306
17MP0003195_calcinosis2.92841186
18MP0003111_abnormal_nucleus_morphology2.87250616
19MP0003077_abnormal_cell_cycle2.82771455
20MP0001666_abnormal_nutrient_absorption2.82174773
21MP0003950_abnormal_plasma_membrane2.57328179
22MP0003786_premature_aging2.55505902
23MP0003941_abnormal_skin_development2.47641581
24MP0008932_abnormal_embryonic_tissue2.31352364
25MP0002118_abnormal_lipid_homeostasis2.09150646
26MP0003191_abnormal_cellular_cholesterol2.05322902
27* MP0000609_abnormal_liver_physiology2.05194004
28MP0009697_abnormal_copulation2.05068262
29MP0003868_abnormal_feces_composition2.00101706
30MP0004019_abnormal_vitamin_homeostasis1.98246756
31MP0010234_abnormal_vibrissa_follicle1.87238267
32MP0005319_abnormal_enzyme/_coenzyme1.87177844
33MP0002138_abnormal_hepatobiliary_system1.86950272
34MP0002163_abnormal_gland_morphology1.77605638
35MP0008057_abnormal_DNA_replication1.77351847
36MP0000358_abnormal_cell_content/1.75865293
37MP0003656_abnormal_erythrocyte_physiolo1.74628267
38MP0003186_abnormal_redox_activity1.66991023
39MP0005584_abnormal_enzyme/coenzyme_acti1.63347068
40MP0005379_endocrine/exocrine_gland_phen1.60061187
41MP0002938_white_spotting1.59949811
42* MP0001764_abnormal_homeostasis1.57633292
43MP0000647_abnormal_sebaceous_gland1.45067670
44MP0010352_gastrointestinal_tract_polyps1.37855174
45MP0009643_abnormal_urine_homeostasis1.34879948
46MP0005451_abnormal_body_composition1.33745007
47MP0002160_abnormal_reproductive_system1.32935092
48MP0005501_abnormal_skin_physiology1.31908019
49MP0001881_abnormal_mammary_gland1.31336558
50MP0003011_delayed_dark_adaptation1.29013813
51MP0006036_abnormal_mitochondrial_physio1.24510107
52MP0006072_abnormal_retinal_apoptosis1.21333298
53MP0002877_abnormal_melanocyte_morpholog1.20190217
54MP0001216_abnormal_epidermal_layer1.17679074
55MP0001727_abnormal_embryo_implantation1.17214166
56MP0002090_abnormal_vision1.16450931
57MP0001697_abnormal_embryo_size1.16362354
58MP0000350_abnormal_cell_proliferation1.15519385
59* MP0000598_abnormal_liver_morphology1.15303479
60MP0002234_abnormal_pharynx_morphology1.14442016
61MP0002006_tumorigenesis1.11453481
62MP0000372_irregular_coat_pigmentation1.11277073
63MP0005647_abnormal_sex_gland1.10272306
64MP0003705_abnormal_hypodermis_morpholog1.09837924
65MP0002796_impaired_skin_barrier1.08208283
66MP0006054_spinal_hemorrhage1.07475208
67MP0005636_abnormal_mineral_homeostasis1.06673446
68MP0005389_reproductive_system_phenotype1.04659259
69MP0010678_abnormal_skin_adnexa1.03552121
70MP0001529_abnormal_vocalization1.03108490
71MP0000627_abnormal_mammary_gland1.02945245
72MP0001730_embryonic_growth_arrest1.02751117
73MP0002019_abnormal_tumor_incidence1.01651649
74MP0005075_abnormal_melanosome_morpholog1.00423162
75MP0005410_abnormal_fertilization1.00419926
76MP0005408_hypopigmentation0.98329129
77MP0009763_increased_sensitivity_to0.97178966
78MP0005084_abnormal_gallbladder_morpholo0.95911422
79MP0000604_amyloidosis0.94651136
80MP0000427_abnormal_hair_cycle0.93766365
81MP0005670_abnormal_white_adipose0.92915953
82MP0009764_decreased_sensitivity_to0.92290239
83MP0005220_abnormal_exocrine_pancreas0.91836533
84MP0009780_abnormal_chondrocyte_physiolo0.91709089
85MP0000313_abnormal_cell_death0.91323169
86MP0003315_abnormal_perineum_morphology0.89434315
87MP0010386_abnormal_urinary_bladder0.87602442
88MP0010771_integument_phenotype0.87203679
89MP0002080_prenatal_lethality0.87084670
90MP0009642_abnormal_blood_homeostasis0.85815378
91MP0008469_abnormal_protein_level0.82425033
92MP0010368_abnormal_lymphatic_system0.82184098
93* MP0005376_homeostasis/metabolism_phenot0.81194084
94MP0010307_abnormal_tumor_latency0.81179915
95MP0002837_dystrophic_cardiac_calcinosis0.81062132
96MP0002210_abnormal_sex_determination0.78775334
97MP0002078_abnormal_glucose_homeostasis0.77963416
98MP0001929_abnormal_gametogenesis0.77528764
99MP0006035_abnormal_mitochondrial_morpho0.77257151
100MP0002254_reproductive_system_inflammat0.76532133
101MP0009765_abnormal_xenobiotic_induced0.75369107
102MP0004130_abnormal_muscle_cell0.74144122
103MP0000613_abnormal_salivary_gland0.72953527
104MP0000383_abnormal_hair_follicle0.72085021
105MP0001661_extended_life_span0.71833594
106MP0008877_abnormal_DNA_methylation0.71323490
107MP0005174_abnormal_tail_pigmentation0.70438429
108MP0009384_cardiac_valve_regurgitation0.70349437
109MP0006292_abnormal_olfactory_placode0.69572189
110MP0001191_abnormal_skin_condition0.69405844
111MP0000749_muscle_degeneration0.68755483
112MP0002876_abnormal_thyroid_physiology0.68048967
113MP0002166_altered_tumor_susceptibility0.67317665
114MP0001756_abnormal_urination0.67233529
115* MP0005266_abnormal_metabolism0.66099616
116MP0002971_abnormal_brown_adipose0.65934350
117MP0004215_abnormal_myocardial_fiber0.65928851
118MP0000653_abnormal_sex_gland0.65001958
119MP0001919_abnormal_reproductive_system0.64838259
120MP0002095_abnormal_skin_pigmentation0.64765793
121MP0005380_embryogenesis_phenotype0.64314012
122MP0001672_abnormal_embryogenesis/_devel0.64314012
123MP0000569_abnormal_digit_pigmentation0.64178839
124MP0001145_abnormal_male_reproductive0.62467097
125MP0005334_abnormal_fat_pad0.61520663
126MP0003329_amyloid_beta_deposits0.60891883
127MP0000639_abnormal_adrenal_gland0.57724149
128MP0003718_maternal_effect0.56702265
129MP0004147_increased_porphyrin_level0.56678501
130MP0003690_abnormal_glial_cell0.56144142
131* MP0005535_abnormal_body_temperature0.53040579
132MP0005448_abnormal_energy_balance0.51799084
133MP0009053_abnormal_anal_canal0.50899284
134MP0003638_abnormal_response/metabolism_0.49860136
135MP0002136_abnormal_kidney_physiology0.48924458
136MP0004782_abnormal_surfactant_physiolog0.48201037
137MP0005395_other_phenotype0.48001862
138MP0000230_abnormal_systemic_arterial0.46147784
139MP0008873_increased_physiological_sensi0.43864144
140MP0005666_abnormal_adipose_tissue0.42626911
141MP0001243_abnormal_dermal_layer0.41828352
142MP0003953_abnormal_hormone_level0.40599809
143MP0005464_abnormal_platelet_physiology0.40267408
144MP0004043_abnormal_pH_regulation0.39521577
145MP0008872_abnormal_physiological_respon0.39029669
146MP0009672_abnormal_birth_weight0.37168568
147MP0001853_heart_inflammation0.36570419
148MP0002269_muscular_atrophy0.35598901
149MP0002822_catalepsy0.35018147
150MP0005166_decreased_susceptibility_to0.32865364
151MP0008874_decreased_physiological_sensi0.32593873
152MP0002928_abnormal_bile_duct0.32054506
153MP0002132_abnormal_respiratory_system0.31495841
154MP0003075_altered_response_to0.31271024
155MP0005058_abnormal_lysosome_morphology0.29707916
156MP0002970_abnormal_white_adipose0.29690191
157MP0005165_increased_susceptibility_to0.29559461
158MP0002060_abnormal_skin_morphology0.29210242
159MP0005330_cardiomyopathy0.28574943
160MP0009115_abnormal_fat_cell0.27735559
161MP0000249_abnormal_blood_vessel0.26448536
162MP0003724_increased_susceptibility_to0.26088453
163MP0005595_abnormal_vascular_smooth0.25948345
164MP0002295_abnormal_pulmonary_circulatio0.25716548
165MP0001542_abnormal_bone_strength0.25329416
166MP0000579_abnormal_nail_morphology0.24789953
167MP0005023_abnormal_wound_healing0.23661623
168MP0008438_abnormal_cutaneous_collagen0.23346289

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.14283815
2Intrahepatic cholestasis (HP:0001406)7.09928944
3Deep venous thrombosis (HP:0002625)6.73858773
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.37962506
5Hypobetalipoproteinemia (HP:0003563)6.13320658
6Prolonged partial thromboplastin time (HP:0003645)6.00420062
7Xanthomatosis (HP:0000991)5.96809971
8Acute necrotizing encephalopathy (HP:0006965)5.22910198
9Hyperlipoproteinemia (HP:0010980)5.22375450
10Abnormal mitochondria in muscle tissue (HP:0008316)4.99735410
11Acute encephalopathy (HP:0006846)4.91463687
12Complement deficiency (HP:0004431)4.85772430
13Hyperammonemia (HP:0001987)4.73772181
14Hypolipoproteinemia (HP:0010981)4.60856285
15Progressive macrocephaly (HP:0004481)4.44578330
16Hyperglycinemia (HP:0002154)4.41566165
17Mitochondrial inheritance (HP:0001427)4.40606329
18Increased CSF lactate (HP:0002490)4.27967624
19Ketosis (HP:0001946)4.27867556
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.19877200
21Abnormality of the common coagulation pathway (HP:0010990)4.19418058
22Fat malabsorption (HP:0002630)4.15789051
23Joint hemorrhage (HP:0005261)4.13331886
24Epidermoid cyst (HP:0200040)4.11889841
25Type I transferrin isoform profile (HP:0003642)4.10256217
26Hypoglycemic coma (HP:0001325)4.09930584
27Hypoalphalipoproteinemia (HP:0003233)4.00596009
28Abnormality of serine family amino acid metabolism (HP:0010894)3.98931095
29Abnormality of glycine metabolism (HP:0010895)3.98931095
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.98214986
31Hyperglycinuria (HP:0003108)3.96692492
32* Abnormality of methionine metabolism (HP:0010901)3.94664421
33Hepatocellular necrosis (HP:0001404)3.90683730
34* Abnormality of sulfur amino acid metabolism (HP:0004339)3.89827961
35* Abnormality of aspartate family amino acid metabolism (HP:0010899)3.89712045
36Abnormality of the intrinsic pathway (HP:0010989)3.77477946
37Increased hepatocellular lipid droplets (HP:0006565)3.76898731
38Abnormality of pyrimidine metabolism (HP:0004353)3.67280530
39Lipid accumulation in hepatocytes (HP:0006561)3.64894965
40Abnormality of fatty-acid metabolism (HP:0004359)3.59681630
41Abnormality of complement system (HP:0005339)3.50556550
42Conjugated hyperbilirubinemia (HP:0002908)3.49120416
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.47453655
44Increased serum pyruvate (HP:0003542)3.46314142
45Abnormal protein glycosylation (HP:0012346)3.31845771
46Abnormal glycosylation (HP:0012345)3.31845771
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.31845771
48Abnormal protein N-linked glycosylation (HP:0012347)3.31845771
49Hypercholesterolemia (HP:0003124)3.31110071
50Abnormality of glycolysis (HP:0004366)3.30809169
51Increased serum lactate (HP:0002151)3.29279043
52Steatorrhea (HP:0002570)3.27528340
53* Hyperbilirubinemia (HP:0002904)3.24577437
54Reduced antithrombin III activity (HP:0001976)3.23652897
55Abnormality of serum amino acid levels (HP:0003112)3.21471214
56Ketoacidosis (HP:0001993)3.20894508
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19637436
58Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19637436
59Delayed CNS myelination (HP:0002188)3.18030136
60Renal Fanconi syndrome (HP:0001994)3.17784160
61Lactic acidosis (HP:0003128)3.16717148
62Microvesicular hepatic steatosis (HP:0001414)2.97623575
63Abnormality of nucleobase metabolism (HP:0010932)2.97500096
64Dicarboxylic aciduria (HP:0003215)2.96409084
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.96409084
66Increased intramyocellular lipid droplets (HP:0012240)2.92751421
67Exercise intolerance (HP:0003546)2.92096871
68Metabolic acidosis (HP:0001942)2.90028961
69Lethargy (HP:0001254)2.88950639
70Hepatocellular carcinoma (HP:0001402)2.87332570
71Cerebral edema (HP:0002181)2.86704820
72Respiratory failure (HP:0002878)2.82673600
733-Methylglutaconic aciduria (HP:0003535)2.81496279
74Methylmalonic acidemia (HP:0002912)2.74963902
75Skin nodule (HP:0200036)2.70074264
76Amniotic constriction ring (HP:0009775)2.68514821
77Abnormality of placental membranes (HP:0011409)2.68514821
78Gout (HP:0001997)2.68439811
79Spontaneous abortion (HP:0005268)2.66997921
80Abnormality of purine metabolism (HP:0004352)2.62609878
81Sparse eyelashes (HP:0000653)2.59920051
82Acanthocytosis (HP:0001927)2.59721178
83Abnormality of the preputium (HP:0100587)2.58520300
84Abnormal gallbladder morphology (HP:0012437)2.58303784
85Vascular calcification (HP:0004934)2.56314667
86Generalized aminoaciduria (HP:0002909)2.50633326
87Myocardial infarction (HP:0001658)2.50385490
88Abnormal gallbladder physiology (HP:0012438)2.50050951
89Cholecystitis (HP:0001082)2.50050951
90Cholelithiasis (HP:0001081)2.49291950
91Increased muscle lipid content (HP:0009058)2.47030520
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41945602
93Abnormality of alanine metabolism (HP:0010916)2.41945602
94Hyperalaninemia (HP:0003348)2.41945602
95Hypochromic microcytic anemia (HP:0004840)2.40040873
96Hypoglycemic seizures (HP:0002173)2.38762052
97Leukodystrophy (HP:0002415)2.37958283
98Hypokinesia (HP:0002375)2.37706098
99Abnormality of the anterior horn cell (HP:0006802)2.36837590
100Degeneration of anterior horn cells (HP:0002398)2.36837590
101CNS demyelination (HP:0007305)2.34935301
102Methylmalonic aciduria (HP:0012120)2.34762032
103Malnutrition (HP:0004395)2.33752706
104Systemic lupus erythematosus (HP:0002725)2.29162218
105Spastic diplegia (HP:0001264)2.29053768
106Cardiovascular calcification (HP:0011915)2.27614507
107Irritability (HP:0000737)2.27562807
108Vomiting (HP:0002013)2.27469273
109Late onset (HP:0003584)2.27013037
110Enlarged kidneys (HP:0000105)2.25997952
111Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25836508
112Neoplasm of the adrenal gland (HP:0100631)2.25734444
113Exertional dyspnea (HP:0002875)2.25734009
114Neonatal onset (HP:0003623)2.20236748
115Chromsome breakage (HP:0040012)2.19848660
116Sensorimotor neuropathy (HP:0007141)2.18477445
117Brushfield spots (HP:0001088)2.15614509
118Opisthotonus (HP:0002179)2.15556215
119Abnormality of chromosome stability (HP:0003220)2.15518402
120Palpitations (HP:0001962)2.14263863
121Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13765425
122Mitral stenosis (HP:0001718)2.13380748
123Meckel diverticulum (HP:0002245)2.12997082
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12992545
125Pancreatitis (HP:0001733)2.12821975
126Conjunctival hamartoma (HP:0100780)2.11256665
127Abnormality of renal resorption (HP:0011038)2.09928441
128Glomerulonephritis (HP:0000099)2.09498679
129Abnormality of the gallbladder (HP:0005264)2.09306849
130Abnormal tarsal ossification (HP:0008369)2.06898107
131Abnormal cartilage morphology (HP:0002763)2.06306035
132Amyloidosis (HP:0011034)2.06274760
133Aplasia/Hypoplasia of the uvula (HP:0010293)2.04310613
134Renal cortical cysts (HP:0000803)2.03091789
135Hyperinsulinemic hypoglycemia (HP:0000825)2.03000120
136Proximal tubulopathy (HP:0000114)2.02614990
137Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02277884
138Optic disc pallor (HP:0000543)2.02184644
139Abnormality of the ileum (HP:0001549)1.98574319
140Poikilocytosis (HP:0004447)1.98319779
141Congenital, generalized hypertrichosis (HP:0004540)1.94403366
142Glycosuria (HP:0003076)1.94020282
143Abnormality of urine glucose concentration (HP:0011016)1.94020282
144Abnormal number of erythroid precursors (HP:0012131)1.93972654
145Dry hair (HP:0011359)1.93005352
146Pancytopenia (HP:0001876)1.92692288
147Testicular atrophy (HP:0000029)1.91455786
148Abnormality of iron homeostasis (HP:0011031)1.90107730
149Nausea (HP:0002018)1.89006579
150Respiratory difficulties (HP:0002880)1.88883836
151Abnormality of transition element cation homeostasis (HP:0011030)1.88841803
152Oral leukoplakia (HP:0002745)1.87229932
153Esophageal varix (HP:0002040)1.86280863
154Abnormalities of placenta or umbilical cord (HP:0001194)1.85684598
155Hydroxyprolinuria (HP:0003080)1.84651582
156Abnormality of proline metabolism (HP:0010907)1.84651582
157Abnormality of vitamin metabolism (HP:0100508)1.84466103
158Hepatic necrosis (HP:0002605)1.84284491
159Onycholysis (HP:0001806)1.84142697
160Rickets (HP:0002748)1.82522825
161Abnormal enzyme/coenzyme activity (HP:0012379)1.81363220
162Thrombophlebitis (HP:0004418)1.81029575
163Neuroendocrine neoplasm (HP:0100634)1.80879888
164Abnormality of cells of the erythroid lineage (HP:0012130)1.80879156
165Increased purine levels (HP:0004368)1.80450465
166Hyperuricemia (HP:0002149)1.80450465
167Alkalosis (HP:0001948)1.79469220
168Aplastic anemia (HP:0001915)1.79138926
169Menorrhagia (HP:0000132)1.78066114
170Spastic paraparesis (HP:0002313)1.76696078
171Absent thumb (HP:0009777)1.75498606
172Macrocytic anemia (HP:0001972)1.75014568
173Poikiloderma (HP:0001029)1.72625012
174Small intestinal stenosis (HP:0012848)1.72406427
175Duodenal stenosis (HP:0100867)1.72406427
176Hypoplastic pelvis (HP:0008839)1.71390517
177Progressive muscle weakness (HP:0003323)1.70919261
178Multiple enchondromatosis (HP:0005701)1.68516432
179Tongue fasciculations (HP:0001308)1.68207395
180Myelodysplasia (HP:0002863)1.67461931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.35843591
2BUB13.83959977
3SIK13.80172434
4VRK23.71165488
5ERN13.59600903
6MST43.53151337
7FGFR43.53143058
8MAP3K122.78504637
9ERBB42.67087120
10INSRR2.49295376
11FLT32.47139307
12ZAK2.39139886
13PIK3CG2.24640814
14PKN22.21660537
15TAOK32.21182412
16CDC72.19057687
17STK38L2.17600539
18TSSK62.10377284
19SRPK12.01450258
20MAP2K41.90947188
21VRK11.90687785
22MST1R1.86690422
23MAPK111.78587499
24FRK1.78275557
25NEK91.77899802
26TTK1.74325746
27WEE11.72674645
28PLK31.72431173
29SCYL21.70495087
30TRIB31.70011721
31KDR1.62332111
32NUAK11.61401125
33ABL21.58759169
34EIF2AK11.54458136
35EPHA21.53688371
36PINK11.52718383
37NME11.51215831
38MAP3K31.48991237
39TAF11.46868051
40PLK41.45103956
41LIMK11.39509084
42LATS11.33941769
43CCNB11.32524119
44MAP2K31.31961138
45TRIM281.29156114
46PLK11.28654335
47MAPKAPK51.28104580
48TYK21.26284292
49EIF2AK21.23111102
50OBSCN1.22977809
51BMPR1B1.22461761
52MET1.22207047
53TLK11.15252573
54PDK31.11472092
55PDK41.11472092
56PAK41.09981162
57MYLK1.08789703
58CDK81.08674348
59DAPK21.08606366
60ERBB31.08199964
61AURKB1.07641833
62MAP4K21.06142374
63PBK1.04203717
64PIK3CA1.03744665
65NEK11.03599119
66TBK11.02826417
67PRKAA21.02325677
68PTK60.95249797
69FGFR20.93074806
70STK160.92014625
71EIF2AK30.91985669
72JAK20.88894613
73MAPK40.87968149
74MAP3K110.86600050
75TIE10.85724126
76MKNK10.84936465
77MAPK120.83737539
78BRSK10.81947137
79ATR0.80922464
80PIM20.80180674
81MAP3K70.79627595
82CHEK20.77849682
83PASK0.77411745
84DAPK10.77404345
85PRKACG0.76320021
86ERBB20.75660377
87MAPK150.73681325
88TESK10.73328032
89MAP2K60.73110148
90CAMK2G0.70952345
91PDK20.69164115
92STK240.68376011
93MKNK20.66945952
94RPS6KB20.66481394
95MUSK0.65939501
96PRKCZ0.64621258
97CDK70.63304132
98GRK60.61117102
99MAP2K10.60901424
100PRKAA10.58934265
101NME20.56649893
102AURKA0.56549219
103PHKG20.56291773
104PHKG10.56291773
105CSNK1A1L0.54034620
106CSNK2A10.52120897
107CDK60.51647003
108WNK40.51093777
109TGFBR10.51039282
110ATM0.50946736
111IGF1R0.50308811
112CSNK2A20.50070423
113ILK0.49923491
114PLK20.49889724
115PRKG20.49579915
116LMTK20.48609288
117MAP3K140.48105698
118PRKCI0.48060465
119CLK10.47726740
120MAPK70.47403685
121BCR0.46926295
122MAP3K50.46327761
123STK100.45992318
124CHEK10.45795633
125SGK2230.44213168
126SGK4940.44213168
127JAK10.43607342
128IRAK30.43429782
129SGK20.43173442
130TAOK20.43060969
131CSNK1G20.42678289
132GSK3A0.42636727
133RPS6KA40.42346220
134PDPK10.41990381
135NEK20.41734177
136SGK30.41251966
137TESK20.41094448
138MAP3K80.41092569
139PTK20.37381585
140BMPR20.37272737
141ADRBK20.37211180
142PRKCQ0.35205534
143STK390.34527417
144PRKCG0.31515614
145CDK40.30960563
146MAPKAPK30.30771179
147STK40.30521417
148PNCK0.30107291
149PRKCA0.29841617
150MAP2K20.29259892
151RPS6KA50.28832344
152CSNK1G10.28375301
153CAMK2D0.28060472
154WNK30.27454600
155RET0.27008841
156CDK90.26493357
157PRKACA0.25213656
158PRKACB0.24970016
159EPHA30.24879746
160IKBKB0.24407924
161LATS20.22758759
162PDK10.22737078
163IKBKE0.22567370
164MAPK30.21803887
165DYRK1B0.21635757
166TGFBR20.21225810
167BRSK20.20458020
168GRK10.20414092
169STK30.18916805
170CSF1R0.18559524
171DAPK30.18221698
172ARAF0.17355304
173CSNK1G30.16917716

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.23071910
2Nitrogen metabolism_Homo sapiens_hsa009103.45558430
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23358000
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18335647
5Mismatch repair_Homo sapiens_hsa034303.00228257
6DNA replication_Homo sapiens_hsa030302.98044337
7Arginine biosynthesis_Homo sapiens_hsa002202.87083742
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72515880
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67008555
10Fatty acid degradation_Homo sapiens_hsa000712.59224523
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58907269
12Tryptophan metabolism_Homo sapiens_hsa003802.57876715
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57012846
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53001574
15Complement and coagulation cascades_Homo sapiens_hsa046102.51263128
16Ribosome_Homo sapiens_hsa030102.48039317
17Homologous recombination_Homo sapiens_hsa034402.48003527
18Nucleotide excision repair_Homo sapiens_hsa034202.25260361
19RNA polymerase_Homo sapiens_hsa030202.23569391
20Propanoate metabolism_Homo sapiens_hsa006402.19923717
21Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15105497
22Peroxisome_Homo sapiens_hsa041462.10087876
23Butanoate metabolism_Homo sapiens_hsa006502.09735489
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05551824
25Fatty acid metabolism_Homo sapiens_hsa012121.89843826
26Chemical carcinogenesis_Homo sapiens_hsa052041.87455161
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83519177
28Histidine metabolism_Homo sapiens_hsa003401.81218298
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77870810
30Non-homologous end-joining_Homo sapiens_hsa034501.77594415
31PPAR signaling pathway_Homo sapiens_hsa033201.77592598
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.75661087
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72973511
34Base excision repair_Homo sapiens_hsa034101.72765648
35Fanconi anemia pathway_Homo sapiens_hsa034601.71807328
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.71801983
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71269742
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70659301
39beta-Alanine metabolism_Homo sapiens_hsa004101.68131067
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66232127
41Huntingtons disease_Homo sapiens_hsa050161.65371101
42Caffeine metabolism_Homo sapiens_hsa002321.65085430
43Selenocompound metabolism_Homo sapiens_hsa004501.64200153
44Pyruvate metabolism_Homo sapiens_hsa006201.60939636
45RNA transport_Homo sapiens_hsa030131.55015029
46Spliceosome_Homo sapiens_hsa030401.54589361
47Retinol metabolism_Homo sapiens_hsa008301.54345180
48Sulfur metabolism_Homo sapiens_hsa009201.53305905
49Phenylalanine metabolism_Homo sapiens_hsa003601.52699414
50Fatty acid elongation_Homo sapiens_hsa000621.49473192
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.43901953
52Steroid biosynthesis_Homo sapiens_hsa001001.40447177
53Staphylococcus aureus infection_Homo sapiens_hsa051501.39409620
54Biosynthesis of amino acids_Homo sapiens_hsa012301.39178564
55Bile secretion_Homo sapiens_hsa049761.38688443
56Tyrosine metabolism_Homo sapiens_hsa003501.38654858
57RNA degradation_Homo sapiens_hsa030181.36039883
58Carbon metabolism_Homo sapiens_hsa012001.36017373
59Folate biosynthesis_Homo sapiens_hsa007901.35432283
60Starch and sucrose metabolism_Homo sapiens_hsa005001.33194020
61Basal transcription factors_Homo sapiens_hsa030221.30469350
62Fat digestion and absorption_Homo sapiens_hsa049751.19180446
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14496914
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13610515
65* Purine metabolism_Homo sapiens_hsa002301.12259606
66Arginine and proline metabolism_Homo sapiens_hsa003301.08725053
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06222453
68Cell cycle_Homo sapiens_hsa041101.04493389
69Cyanoamino acid metabolism_Homo sapiens_hsa004601.04206151
70ABC transporters_Homo sapiens_hsa020101.03633328
71N-Glycan biosynthesis_Homo sapiens_hsa005101.00412935
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.98212874
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95416806
74One carbon pool by folate_Homo sapiens_hsa006700.92923078
75Sulfur relay system_Homo sapiens_hsa041220.91833511
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91040870
77Vitamin B6 metabolism_Homo sapiens_hsa007500.89636216
78Vitamin digestion and absorption_Homo sapiens_hsa049770.88973509
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88707012
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86723788
81Glutathione metabolism_Homo sapiens_hsa004800.79805194
82p53 signaling pathway_Homo sapiens_hsa041150.72747451
83Glycerolipid metabolism_Homo sapiens_hsa005610.72057106
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69549661
85Pentose phosphate pathway_Homo sapiens_hsa000300.68851561
86Lysine degradation_Homo sapiens_hsa003100.67036743
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61290356
88Fatty acid biosynthesis_Homo sapiens_hsa000610.56685930
89* Metabolic pathways_Homo sapiens_hsa011000.56631438
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48034084
91Cardiac muscle contraction_Homo sapiens_hsa042600.45468305
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43803870
93Fructose and mannose metabolism_Homo sapiens_hsa000510.38894935
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38854095
95Oocyte meiosis_Homo sapiens_hsa041140.36826430
96Galactose metabolism_Homo sapiens_hsa000520.35805301
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34499813
98Sphingolipid metabolism_Homo sapiens_hsa006000.31308110
99Legionellosis_Homo sapiens_hsa051340.31274183
100Epstein-Barr virus infection_Homo sapiens_hsa051690.26711955
101mRNA surveillance pathway_Homo sapiens_hsa030150.24538238
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23602567
103Prion diseases_Homo sapiens_hsa050200.22287529
104Vibrio cholerae infection_Homo sapiens_hsa051100.22244092
105Linoleic acid metabolism_Homo sapiens_hsa005910.21584614
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19122457
107Collecting duct acid secretion_Homo sapiens_hsa049660.17204394
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.15794750
109Insulin resistance_Homo sapiens_hsa049310.15701634
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13493132
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13403196
112Other glycan degradation_Homo sapiens_hsa005110.12930872
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.12040945
114Glucagon signaling pathway_Homo sapiens_hsa049220.08385976
115Protein export_Homo sapiens_hsa030600.02839912
116Oxidative phosphorylation_Homo sapiens_hsa001900.01903675
117Mineral absorption_Homo sapiens_hsa04978-0.2216723
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1788684
119Proteasome_Homo sapiens_hsa03050-0.1680875
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1579038
121Alzheimers disease_Homo sapiens_hsa05010-0.1371212
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1365494
123Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1312472
124Insulin signaling pathway_Homo sapiens_hsa04910-0.1303522
125Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1289937
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1232634
127Pyrimidine metabolism_Homo sapiens_hsa00240-0.0933224
128Regulation of autophagy_Homo sapiens_hsa04140-0.0908079
129Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0769391
130Renin-angiotensin system_Homo sapiens_hsa04614-0.0358847
131Protein digestion and absorption_Homo sapiens_hsa04974-0.0266280
132AMPK signaling pathway_Homo sapiens_hsa04152-0.0190200
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0179925
134Parkinsons disease_Homo sapiens_hsa05012-0.0076173

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