ADM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of lipoprotein metabolic process (GO:0050746)8.44143817
2wound healing, spreading of epidermal cells (GO:0035313)7.49231534
3blood vessel maturation (GO:0001955)7.45566694
4keratinocyte development (GO:0003334)7.35584074
5trophectodermal cell differentiation (GO:0001829)6.90516634
6cell differentiation involved in embryonic placenta development (GO:0060706)6.88792739
7bundle of His cell to Purkinje myocyte communication (GO:0086069)6.58163735
8placenta development (GO:0001890)6.46368363
9trophoblast giant cell differentiation (GO:0060707)6.42765510
10regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)6.28672252
11dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.86959431
12wound healing, spreading of cells (GO:0044319)5.62295318
13regulation of tight junction assembly (GO:2000810)5.18859816
14cartilage morphogenesis (GO:0060536)5.14098803
15cytoskeletal anchoring at plasma membrane (GO:0007016)4.92168046
16desmosome organization (GO:0002934)4.91867704
17mesodermal cell differentiation (GO:0048333)4.79642791
18vitamin A metabolic process (GO:0006776)4.79063991
19phospholipid homeostasis (GO:0055091)4.78719148
20angiogenesis involved in wound healing (GO:0060055)4.64412096
21low-density lipoprotein particle clearance (GO:0034383)4.56943675
22regulation of vitamin D biosynthetic process (GO:0060556)4.56927677
23axon extension involved in axon guidance (GO:0048846)4.54531834
24neuron projection extension involved in neuron projection guidance (GO:1902284)4.54531834
25regulation of transforming growth factor beta2 production (GO:0032909)4.48852928
26adhesion of symbiont to host cell (GO:0044650)4.44245043
27virion attachment to host cell (GO:0019062)4.44245043
28negative chemotaxis (GO:0050919)4.28703650
29negative regulation of smooth muscle cell migration (GO:0014912)4.27879519
30regulation of establishment of cell polarity (GO:2000114)4.23530190
31negative regulation of activin receptor signaling pathway (GO:0032926)4.21780662
32positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.07935559
33regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.06886029
34positive regulation of p38MAPK cascade (GO:1900745)4.06803803
35maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.06374605
36regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.00064030
37ganglion development (GO:0061548)3.96754298
38positive regulation of chemokine biosynthetic process (GO:0045080)3.92906146
39histone H2A monoubiquitination (GO:0035518)3.92480816
40regulation of membrane protein ectodomain proteolysis (GO:0051043)3.83848657
41collagen fibril organization (GO:0030199)3.79159840
42mammary gland epithelial cell proliferation (GO:0033598)3.79125698
43basement membrane organization (GO:0071711)3.78914899
44semaphorin-plexin signaling pathway (GO:0071526)3.78036521
45cell migration involved in heart development (GO:0060973)3.75746531
46adhesion of symbiont to host (GO:0044406)3.75177458
47high-density lipoprotein particle remodeling (GO:0034375)3.74330710
48icosanoid secretion (GO:0032309)3.66890148
49arachidonic acid secretion (GO:0050482)3.66890148
50platelet aggregation (GO:0070527)3.65202443
51negative regulation of nitric oxide biosynthetic process (GO:0045019)3.64480894
52negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.63864644
53regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.63609839
54embryonic heart tube development (GO:0035050)3.62000355
55regulation of establishment or maintenance of cell polarity (GO:0032878)3.57764482
56regulation of vitamin metabolic process (GO:0030656)3.57005532
57regulation of cytokine secretion involved in immune response (GO:0002739)3.56433442
58cell adhesion mediated by integrin (GO:0033627)3.53854774
59cellular response to cadmium ion (GO:0071276)3.53355285
60establishment of endothelial barrier (GO:0061028)3.52491218
61regulation of lipoprotein particle clearance (GO:0010984)3.49901247
62regulation of chemokine biosynthetic process (GO:0045073)3.48750400
63muscle cell migration (GO:0014812)3.48717848
64cardiac ventricle formation (GO:0003211)3.45182418
65endodermal cell differentiation (GO:0035987)3.44712134
66phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.42314618
67cellular response to arsenic-containing substance (GO:0071243)3.39573542
68regulation of mononuclear cell migration (GO:0071675)3.35017434
69positive regulation of megakaryocyte differentiation (GO:0045654)3.34071931
70wound healing (GO:0042060)3.32203242
71extracellular matrix assembly (GO:0085029)3.30700749
72actin nucleation (GO:0045010)3.28853090
73adherens junction organization (GO:0034332)3.28581950
74mRNA transcription (GO:0009299)3.28337101
75mesenchymal-epithelial cell signaling (GO:0060638)3.27116810
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.25793952
77NLS-bearing protein import into nucleus (GO:0006607)3.22668301
78substrate adhesion-dependent cell spreading (GO:0034446)3.22346280
79phosphatidylserine acyl-chain remodeling (GO:0036150)3.21843942
80type B pancreatic cell proliferation (GO:0044342)3.21712886
81sequestering of metal ion (GO:0051238)3.21508562
82phosphatidylinositol acyl-chain remodeling (GO:0036149)3.21026236
83keratinocyte proliferation (GO:0043616)3.19845071
84positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.19691892
85cardiac chamber formation (GO:0003207)3.19157079
86anatomical structure maturation (GO:0071695)3.18836717
87activation of MAPKKK activity (GO:0000185)3.18659447
88heterotypic cell-cell adhesion (GO:0034113)3.17786482
89viral entry into host cell (GO:0046718)3.17731201
90protein heterotrimerization (GO:0070208)3.16747422
91positive regulation of macrophage activation (GO:0043032)3.14603768
92regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.13497563
93reverse cholesterol transport (GO:0043691)3.13376018
94icosanoid transport (GO:0071715)3.13219638
95fatty acid derivative transport (GO:1901571)3.13219638
96positive regulation of monooxygenase activity (GO:0032770)3.11376280
97cell-substrate junction assembly (GO:0007044)3.10657098
98decidualization (GO:0046697)3.09284147
99glomerular basement membrane development (GO:0032836)3.08376581
100regulation of T-helper 1 cell differentiation (GO:0045625)3.08075047
101negative regulation of axon extension involved in axon guidance (GO:0048843)3.07756581
102positive regulation of immune response to tumor cell (GO:0002839)3.05402787
103regulation of immune response to tumor cell (GO:0002837)3.05402787
104regulation of response to tumor cell (GO:0002834)3.05402787
105positive regulation of response to tumor cell (GO:0002836)3.05402787
106collagen metabolic process (GO:0032963)3.05306703
107regulation of nitric oxide biosynthetic process (GO:0045428)3.03730822
108protein retention in ER lumen (GO:0006621)3.00593290
109glomerular visceral epithelial cell development (GO:0072015)2.99842572
110protein localization to endosome (GO:0036010)2.99752391
111barbed-end actin filament capping (GO:0051016)2.98082630
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.97815078
113kidney mesenchyme development (GO:0072074)2.97351747
114hyaluronan catabolic process (GO:0030214)2.97212928
115collagen catabolic process (GO:0030574)2.94452504
116fibril organization (GO:0097435)2.93127572
117response to gravity (GO:0009629)2.92919377
118skin morphogenesis (GO:0043589)2.92236027
119response to peptidoglycan (GO:0032494)2.90942018
120tooth mineralization (GO:0034505)2.90791758
121maternal placenta development (GO:0001893)2.89590054
122labyrinthine layer development (GO:0060711)2.88775971
123peptidyl-proline hydroxylation (GO:0019511)2.88579802
124negative regulation of interleukin-12 production (GO:0032695)2.88349477
125positive regulation of heat generation (GO:0031652)2.87897679
126cellular response to interferon-alpha (GO:0035457)2.86969920
127epithelial cell-cell adhesion (GO:0090136)2.86188165
128negative regulation of fatty acid transport (GO:2000192)2.85281237
129blastocyst development (GO:0001824)2.85267993
130regulation of fever generation (GO:0031620)2.84941963
131homotypic cell-cell adhesion (GO:0034109)2.82680851
132chronic inflammatory response (GO:0002544)2.82574378
133Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81614559
134COPI coating of Golgi vesicle (GO:0048205)2.81098028
135Golgi transport vesicle coating (GO:0048200)2.81098028
136positive regulation of nitric oxide biosynthetic process (GO:0045429)2.79233192
137positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.78692435
138substrate-dependent cell migration (GO:0006929)2.78147219
139negative regulation of lipid storage (GO:0010888)2.77196691
140positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.75635814
141multicellular organismal macromolecule metabolic process (GO:0044259)2.75367486
142regulation of T-helper 2 cell differentiation (GO:0045628)2.74676757
143positive regulation of endothelial cell apoptotic process (GO:2000353)2.74596844
144metanephric mesenchyme development (GO:0072075)2.73310601
145keratan sulfate catabolic process (GO:0042340)2.72746157
146ovulation from ovarian follicle (GO:0001542)2.71019186
147response to laminar fluid shear stress (GO:0034616)2.69818406
148regulation of podosome assembly (GO:0071801)2.69144102
149extracellular fibril organization (GO:0043206)2.67283924
150regulation of p38MAPK cascade (GO:1900744)2.66429450
151venous blood vessel morphogenesis (GO:0048845)2.66299796
152regulation of heterotypic cell-cell adhesion (GO:0034114)2.66279098
153vascular endothelial growth factor signaling pathway (GO:0038084)2.64707772
154bone trabecula formation (GO:0060346)2.64503360
155multicellular organismal catabolic process (GO:0044243)2.64261088
156lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63010803
157multicellular organismal metabolic process (GO:0044236)2.61820062
158cellular response to type I interferon (GO:0071357)2.61211781
159type I interferon signaling pathway (GO:0060337)2.61211781
160cellular response to vitamin (GO:0071295)2.59875291
161response to type I interferon (GO:0034340)2.58718951
162extracellular matrix disassembly (GO:0022617)2.58092700
163regulation of endothelial cell apoptotic process (GO:2000351)2.57794978
164positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56766355
165regulation of early endosome to late endosome transport (GO:2000641)2.55658222
166apoptotic cell clearance (GO:0043277)2.55502688
167protein hydroxylation (GO:0018126)2.53870190
168heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.52848858
169pinocytosis (GO:0006907)2.52803687
170chondrocyte proliferation (GO:0035988)2.52563654
171regulation of transforming growth factor beta1 production (GO:0032908)2.51228190
172positive regulation of interleukin-6 production (GO:0032755)2.50650786
173endocytic recycling (GO:0032456)2.48705467
174regulation of monocyte chemotaxis (GO:0090025)2.47174429
175regulation of chronic inflammatory response (GO:0002676)2.46405043
176stress fiber assembly (GO:0043149)2.44013044
177platelet-derived growth factor receptor signaling pathway (GO:0048008)2.43923581
178vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41093646
179regulation of apoptotic process involved in morphogenesis (GO:1902337)2.40423121
180planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39615462
181embryo implantation (GO:0007566)2.39366474
182response to vitamin D (GO:0033280)2.38268019
183positive regulation of fat cell differentiation (GO:0045600)2.37711748
184positive regulation of extracellular matrix organization (GO:1903055)2.35955184
185cellular response to amino acid stimulus (GO:0071230)2.35902877
186negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.35018575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.03423485
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.97459536
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.85567884
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.93885404
5ESR1_15608294_ChIP-ChIP_MCF-7_Human3.86854314
6CLOCK_20551151_ChIP-Seq_293T_Human3.81607244
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.22387958
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.20711095
9ESR2_21235772_ChIP-Seq_MCF-7_Human3.20316401
10CDX2_19796622_ChIP-Seq_MESCs_Mouse3.06579915
11ESR1_21235772_ChIP-Seq_MCF-7_Human3.00090996
12EGR1_19032775_ChIP-ChIP_M12_Human2.98078369
13SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.71545666
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.70998974
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57360270
16AR_21909140_ChIP-Seq_LNCAP_Human2.48253242
17* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.44097583
18* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.25071850
19* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.17769988
20* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.17769988
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.08398475
22* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00330695
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99453947
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98692605
25SALL4_18804426_ChIP-ChIP_XEN_Mouse1.94804935
26* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.90184744
27* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87781055
28* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.87202456
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82331561
30* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.82151438
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81742928
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77586542
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.74431436
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72848516
35SOX2_20726797_ChIP-Seq_SW620_Human1.71675297
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71505520
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68728575
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.66133871
39* ELK3_25401928_ChIP-Seq_HUVEC_Human1.64789400
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.63354955
41* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59722040
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.59312163
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57545361
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56928383
45TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53344918
46HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.51610979
47BRD4_25478319_ChIP-Seq_HGPS_Human1.47165036
48* CJUN_26792858_Chip-Seq_BT549_Human1.46327392
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44762709
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44431621
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44431621
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44431621
53* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43695336
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42644545
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.38726834
56* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.34832347
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.34279508
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33868763
59* ATF3_27146783_Chip-Seq_COLON_Human1.32927473
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31000474
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.30786951
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.30689024
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30194264
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.29714980
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29013003
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26648761
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25107999
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23957666
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22742084
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22550102
71TP53_16413492_ChIP-PET_HCT116_Human1.22358400
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.21372217
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19588899
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19143754
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19054386
76* LXR_22292898_ChIP-Seq_THP-1_Human1.17288260
77* RACK7_27058665_Chip-Seq_MCF-7_Human1.15480468
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14906642
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14739654
80* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14599060
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14241468
82* SA1_22415368_ChIP-Seq_MEFs_Mouse1.10939467
83* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10304021
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10262940
85* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09044260
86* EP300_21415370_ChIP-Seq_HL-1_Mouse1.08447722
87* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08393483
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07401861
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07271868
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07173753
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06612621
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05961582
93* KDM2B_26808549_Chip-Seq_K562_Human1.04586227
94* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03076481
95VDR_24787735_ChIP-Seq_THP-1_Human1.01504108
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01025183
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.00998413
98* GATA4_25053715_ChIP-Seq_YYC3_Human1.00738320
99* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99663272
100* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99328638
101GATA3_24758297_ChIP-Seq_MCF-7_Human0.98612773
102VDR_24763502_ChIP-Seq_THP-1_Human0.97536224
103TP53_18474530_ChIP-ChIP_U2OS_Human0.96678184
104* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96344224
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93671218
106TP53_22127205_ChIP-Seq_IMR90_Human0.93661624
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93213862
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91981095
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90963898
110NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90834755
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90834755
112* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90684825
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90556217
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.89747226
115* KDM2B_26808549_Chip-Seq_DND41_Human0.89489018
116RXR_22158963_ChIP-Seq_LIVER_Mouse0.88833976
117* TP53_20018659_ChIP-ChIP_R1E_Mouse0.88264897
118CHD1_26751641_Chip-Seq_LNCaP_Human0.88048474
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87906537
120* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87418500
121* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87329691
122TP63_23658742_ChIP-Seq_EP156T_Human0.84399197
123KLF5_25053715_ChIP-Seq_YYC3_Human0.84189652
124MYC_18555785_ChIP-Seq_MESCs_Mouse0.83928822
125* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83152113
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82957963
127RUNX1_27514584_Chip-Seq_MCF-7_Human0.82799068
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.82450153
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.82450153
130MYC_22102868_ChIP-Seq_BL_Human0.81973812
131* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81239667
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79006633
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.78003026
134* GATA6_25053715_ChIP-Seq_YYC3_Human0.77503867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog7.24067653
2MP0003123_paternal_imprinting4.52406983
3MP0008438_abnormal_cutaneous_collagen3.73228901
4MP0010352_gastrointestinal_tract_polyps3.52518914
5MP0006054_spinal_hemorrhage3.49062008
6MP0003566_abnormal_cell_adhesion3.38372445
7MP0004510_myositis3.25262036
8MP0005623_abnormal_meninges_morphology3.24674077
9MP0005023_abnormal_wound_healing3.20673374
10MP0000013_abnormal_adipose_tissue3.16185801
11MP0001542_abnormal_bone_strength3.02726332
12MP0003303_peritoneal_inflammation2.97798175
13MP0004264_abnormal_extraembryonic_tissu2.85161469
14MP0000003_abnormal_adipose_tissue2.62448963
15MP0004084_abnormal_cardiac_muscle2.62403949
16MP0008775_abnormal_heart_ventricle2.54797389
17MP0003279_aneurysm2.51320503
18MP0005275_abnormal_skin_tensile2.41016497
19MP0003453_abnormal_keratinocyte_physiol2.23588294
20MP0005058_abnormal_lysosome_morphology2.12991910
21MP0006082_CNS_inflammation2.10069749
22MP0003121_genomic_imprinting2.06041524
23MP0009840_abnormal_foam_cell2.05997696
24MP0003941_abnormal_skin_development1.98060126
25MP0005503_abnormal_tendon_morphology1.91719534
26MP0003091_abnormal_cell_migration1.91679470
27MP0003567_abnormal_fetal_cardiomyocyte1.80937422
28MP0003300_gastrointestinal_ulcer1.79685315
29MP0000383_abnormal_hair_follicle1.79048457
30MP0003436_decreased_susceptibility_to1.78945879
31MP0005257_abnormal_intraocular_pressure1.77204460
32* MP0004272_abnormal_basement_membrane1.75836100
33* MP0002086_abnormal_extraembryonic_tissu1.73004092
34MP0008004_abnormal_stomach_pH1.69183523
35MP0003191_abnormal_cellular_cholesterol1.65537409
36MP0003787_abnormal_imprinting1.63332057
37MP0004947_skin_inflammation1.63192190
38MP0002148_abnormal_hypersensitivity_rea1.54285524
39MP0002254_reproductive_system_inflammat1.53900106
40MP0005390_skeleton_phenotype1.52246529
41MP0010368_abnormal_lymphatic_system1.47928007
42MP0005076_abnormal_cell_differentiation1.45836944
43MP0003183_abnormal_peptide_metabolism1.42240667
44MP0010678_abnormal_skin_adnexa1.38742640
45MP0009384_cardiac_valve_regurgitation1.38527208
46MP0003448_altered_tumor_morphology1.37541838
47MP0002060_abnormal_skin_morphology1.35919837
48MP0003122_maternal_imprinting1.34957174
49MP0004858_abnormal_nervous_system1.34597242
50MP0000465_gastrointestinal_hemorrhage1.33928494
51MP0009764_decreased_sensitivity_to1.31037796
52MP0005595_abnormal_vascular_smooth1.30685909
53MP0002837_dystrophic_cardiac_calcinosis1.29867076
54MP0001958_emphysema1.28095968
55MP0003950_abnormal_plasma_membrane1.27365771
56MP0005375_adipose_tissue_phenotype1.24950153
57MP0009053_abnormal_anal_canal1.21437112
58MP0004197_abnormal_fetal_growth/weight/1.19126975
59MP0004036_abnormal_muscle_relaxation1.16426320
60MP0003385_abnormal_body_wall1.16039440
61MP0000604_amyloidosis1.13335410
62MP0009278_abnormal_bone_marrow1.09602425
63MP0002419_abnormal_innate_immunity1.09416124
64MP0002332_abnormal_exercise_endurance1.03574549
65* MP0002925_abnormal_cardiovascular_devel1.01907348
66MP0001697_abnormal_embryo_size1.00558513
67MP0002933_joint_inflammation0.98794772
68MP0003984_embryonic_growth_retardation0.98151778
69MP0002088_abnormal_embryonic_growth/wei0.97312244
70MP0002998_abnormal_bone_remodeling0.96557449
71MP0005165_increased_susceptibility_to0.95809641
72MP0001879_abnormal_lymphatic_vessel0.95017613
73* MP0000249_abnormal_blood_vessel0.94575712
74MP0000343_altered_response_to0.93631607
75MP0003828_pulmonary_edema0.92929420
76MP0001915_intracranial_hemorrhage0.92593540
77MP0001849_ear_inflammation0.91197054
78* MP0001614_abnormal_blood_vessel0.90099427
79MP0003795_abnormal_bone_structure0.89769216
80MP0001348_abnormal_lacrimal_gland0.89353610
81MP0008260_abnormal_autophagy0.89031160
82MP0005451_abnormal_body_composition0.88487817
83MP0002108_abnormal_muscle_morphology0.88381809
84MP0001243_abnormal_dermal_layer0.87905675
85* MP0002128_abnormal_blood_circulation0.86709315
86MP0005000_abnormal_immune_tolerance0.85643417
87MP0000750_abnormal_muscle_regeneration0.84573115
88MP0002796_impaired_skin_barrier0.84519861
89MP0005025_abnormal_response_to0.83845363
90MP0000767_abnormal_smooth_muscle0.83348039
91* MP0002295_abnormal_pulmonary_circulatio0.82945610
92MP0005164_abnormal_response_to0.82826672
93MP0004883_abnormal_blood_vessel0.82597323
94MP0005464_abnormal_platelet_physiology0.82194892
95MP0000858_altered_metastatic_potential0.80369286
96MP0010630_abnormal_cardiac_muscle0.79801978
97MP0005380_embryogenesis_phenotype0.78650832
98MP0001672_abnormal_embryogenesis/_devel0.78650832
99MP0003724_increased_susceptibility_to0.76833791
100MP0002877_abnormal_melanocyte_morpholog0.76692308
101MP0005387_immune_system_phenotype0.76615892
102MP0001790_abnormal_immune_system0.76615892
103MP0002127_abnormal_cardiovascular_syste0.76561849
104MP0001544_abnormal_cardiovascular_syste0.74352420
105MP0005385_cardiovascular_system_phenoty0.74352420
106MP0001730_embryonic_growth_arrest0.74283060
107MP0001346_abnormal_lacrimal_gland0.74016334
108MP0001299_abnormal_eye_distance/0.72766004
109MP0000428_abnormal_craniofacial_morphol0.72748882
110MP0001216_abnormal_epidermal_layer0.72685463
111* MP0002972_abnormal_cardiac_muscle0.70483984
112MP0008007_abnormal_cellular_replicative0.70237827
113MP0001853_heart_inflammation0.70096365
114MP0000266_abnormal_heart_morphology0.67793532
115MP0000377_abnormal_hair_follicle0.67641029
116MP0009931_abnormal_skin_appearance0.67254945
117MP0008469_abnormal_protein_level0.66117510
118MP0004484_altered_response_of0.65835799
119MP0003075_altered_response_to0.65682796
120MP0005670_abnormal_white_adipose0.65332084
121MP0005166_decreased_susceptibility_to0.64756143
122MP0000647_abnormal_sebaceous_gland0.64675792
123MP0002113_abnormal_skeleton_development0.64296326
124MP0005397_hematopoietic_system_phenotyp0.64023612
125MP0001545_abnormal_hematopoietic_system0.64023612
126MP0002084_abnormal_developmental_patter0.63518628
127MP0000685_abnormal_immune_system0.63019276
128MP0000627_abnormal_mammary_gland0.62838518
129MP0004233_abnormal_muscle_weight0.62687873
130MP0001835_abnormal_antigen_presentation0.62356570
131MP0000163_abnormal_cartilage_morphology0.61596555
132MP0002115_abnormal_skeleton_extremities0.61429552
133MP0005666_abnormal_adipose_tissue0.61263557
134MP0002405_respiratory_system_inflammati0.60631052
135MP0002452_abnormal_antigen_presenting0.59986109
136MP0005508_abnormal_skeleton_morphology0.59538969
137MP0004087_abnormal_muscle_fiber0.59496056
138MP0001533_abnormal_skeleton_physiology0.58943885
139* MP0001845_abnormal_inflammatory_respons0.58760143
140MP0003755_abnormal_palate_morphology0.58550881
141MP0010030_abnormal_orbit_morphology0.58504486
142MP0005501_abnormal_skin_physiology0.58104334
143MP0010771_integument_phenotype0.57697891
144MP0005193_abnormal_anterior_eye0.57320218
145* MP0003221_abnormal_cardiomyocyte_apopto0.56948309
146MP0003329_amyloid_beta_deposits0.56188774
147MP0009250_abnormal_appendicular_skeleto0.55075051
148MP0005197_abnormal_uvea_morphology0.53904613
149* MP0002080_prenatal_lethality0.53760046
150MP0000733_abnormal_muscle_development0.53756159
151* MP0009763_increased_sensitivity_to0.53574497
152MP0009785_altered_susceptibility_to0.52801600
153MP0002896_abnormal_bone_mineralization0.52777827

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.51147684
2Protrusio acetabuli (HP:0003179)5.23462040
3Premature rupture of membranes (HP:0001788)4.49770817
4Pili torti (HP:0003777)4.42748431
5Follicular hyperkeratosis (HP:0007502)4.39257123
6Selective tooth agenesis (HP:0001592)4.28862522
7Abnormality of liposaccharide metabolism (HP:0010968)4.24552487
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.24552487
9Abnormality of glycolipid metabolism (HP:0010969)4.24552487
10Cervical subluxation (HP:0003308)4.17991973
11Increased mean platelet volume (HP:0011877)4.15409029
12Abnormal platelet volume (HP:0011876)4.10576686
13Bladder diverticulum (HP:0000015)3.93969138
14Purpura (HP:0000979)3.85289769
15Deep venous thrombosis (HP:0002625)3.84780047
16Persistence of primary teeth (HP:0006335)3.80872117
17Asymmetry of the thorax (HP:0001555)3.76812425
18Petechiae (HP:0000967)3.59908204
19Nuclear cataract (HP:0100018)3.52334066
20Vertebral compression fractures (HP:0002953)3.42906255
21Neonatal short-limb short stature (HP:0008921)3.39260245
22Genu recurvatum (HP:0002816)3.34018059
23Arterial tortuosity (HP:0005116)3.31619751
24Submucous cleft hard palate (HP:0000176)3.20179819
25Abnormality of dentin (HP:0010299)3.16953827
26Type 1 muscle fiber predominance (HP:0003803)3.12988164
27Ankle contracture (HP:0006466)3.12718464
28Bowel diverticulosis (HP:0005222)3.10022260
29Spinal cord compression (HP:0002176)3.06651706
30Spondylolisthesis (HP:0003302)3.03802643
31Slender build (HP:0001533)3.00465887
32Septate vagina (HP:0001153)3.00329023
33Hydroxyprolinuria (HP:0003080)2.96287841
34Abnormality of proline metabolism (HP:0010907)2.96287841
35Atrophic scars (HP:0001075)2.95028778
36Dysostosis multiplex (HP:0000943)2.90703206
37Overriding aorta (HP:0002623)2.89662844
38Bilateral sensorineural hearing impairment (HP:0008619)2.89449975
39Thin bony cortex (HP:0002753)2.87259386
40Hyperacusis (HP:0010780)2.81177811
41Shallow orbits (HP:0000586)2.78664443
42Increased connective tissue (HP:0009025)2.76129243
43Soft skin (HP:0000977)2.67852647
44Biconcave vertebral bodies (HP:0004586)2.66961702
45Flat cornea (HP:0007720)2.65463490
46Hypotrichosis (HP:0001006)2.64509634
47Dilatation of the ascending aorta (HP:0005111)2.64137871
48Menorrhagia (HP:0000132)2.64087884
49Peritonitis (HP:0002586)2.63476907
50Aortic aneurysm (HP:0004942)2.62552203
51Renal duplication (HP:0000075)2.62480350
52Short nail (HP:0001799)2.62428636
53Wormian bones (HP:0002645)2.61078296
54Elfin facies (HP:0004428)2.59839507
55Systemic lupus erythematosus (HP:0002725)2.54931370
56Nonimmune hydrops fetalis (HP:0001790)2.51780270
57Vacuolated lymphocytes (HP:0001922)2.49582589
58Heterochromia iridis (HP:0001100)2.49343633
59Hyperextensible skin (HP:0000974)2.47684832
60Aortic regurgitation (HP:0001659)2.47362288
61Abnormal hair laboratory examination (HP:0003328)2.45845680
62Renovascular hypertension (HP:0100817)2.43044763
63Abnormal platelet function (HP:0011869)2.40287565
64Impaired platelet aggregation (HP:0003540)2.40287565
65Woolly hair (HP:0002224)2.39282024
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38553029
67Abnormality of polysaccharide metabolism (HP:0011012)2.38553029
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38553029
69Exercise-induced muscle cramps (HP:0003710)2.38276441
70Hallux valgus (HP:0001822)2.37593862
71Mitral regurgitation (HP:0001653)2.37163614
72Mitral valve prolapse (HP:0001634)2.33243671
73Urinary glycosaminoglycan excretion (HP:0003541)2.32096262
74Mucopolysacchariduria (HP:0008155)2.32096262
75Aneurysm (HP:0002617)2.28861399
76Deviation of the hallux (HP:0010051)2.28830763
77Coronal craniosynostosis (HP:0004440)2.28347101
78Joint laxity (HP:0001388)2.28048592
79Increased variability in muscle fiber diameter (HP:0003557)2.26715437
80Fragile skin (HP:0001030)2.26410153
81Elbow flexion contracture (HP:0002987)2.25785601
82Natal tooth (HP:0000695)2.25761084
83Aortic dissection (HP:0002647)2.24536356
84Insomnia (HP:0100785)2.23796115
85Axonal loss (HP:0003447)2.22455216
86Neurofibrillary tangles (HP:0002185)2.20832426
87Thoracolumbar scoliosis (HP:0002944)2.20203789
88Scapular winging (HP:0003691)2.19957641
89Gingival bleeding (HP:0000225)2.18918390
90Palpitations (HP:0001962)2.18036919
91Ventricular tachycardia (HP:0004756)2.17884460
92Broad metatarsal (HP:0001783)2.15444923
93Overgrowth (HP:0001548)2.12449896
94Loss of speech (HP:0002371)2.09060822
95Aortic valve stenosis (HP:0001650)2.08316023
96Vascular tortuosity (HP:0004948)2.07703622
97Exostoses (HP:0100777)2.07223606
98Joint stiffness (HP:0001387)2.06851927
99Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.02657263
100Buphthalmos (HP:0000557)2.01909418
101Emphysema (HP:0002097)1.99564107
102Abnormality of macrophages (HP:0004311)1.99345504
103Cerebral aneurysm (HP:0004944)1.99036239
104Hyporeflexia of lower limbs (HP:0002600)1.98942726
105Mildly elevated creatine phosphokinase (HP:0008180)1.97770067
106Achilles tendon contracture (HP:0001771)1.97410533
107Distal lower limb muscle weakness (HP:0009053)1.97229954
108Wide anterior fontanel (HP:0000260)1.95562354
109Esophageal atresia (HP:0002032)1.95128166
110Myocardial infarction (HP:0001658)1.95059829
111Acrocyanosis (HP:0001063)1.93573433
112Femoral bowing (HP:0002980)1.93089776
113Oligodontia (HP:0000677)1.91392635
114Orchitis (HP:0100796)1.90789881
115Ulnar bowing (HP:0003031)1.90709792
116Generalized amyotrophy (HP:0003700)1.90542967
117Ovoid vertebral bodies (HP:0003300)1.90400582
118Camptodactyly of toe (HP:0001836)1.90141882
119Sparse lateral eyebrow (HP:0005338)1.90116994
120Multifactorial inheritance (HP:0001426)1.88487477
121Abnormality of skeletal muscle fiber size (HP:0012084)1.87889912
122Enlarged penis (HP:0000040)1.86243442
123Radial bowing (HP:0002986)1.85393227
124Protruding ear (HP:0000411)1.84786216
125Abnormality of the gastric mucosa (HP:0004295)1.84642421
126Pointed chin (HP:0000307)1.83934498
127Blue sclerae (HP:0000592)1.83681721
128Abnormality of the Achilles tendon (HP:0005109)1.82756172
129Long toe (HP:0010511)1.81547124
130Ectopia lentis (HP:0001083)1.81079035
131Wrist flexion contracture (HP:0001239)1.80273196
132Absent frontal sinuses (HP:0002688)1.80213930
133Amyloidosis (HP:0011034)1.80185246
134Tetraparesis (HP:0002273)1.79611627
135Webbed neck (HP:0000465)1.79516666
136Abnormality of skull ossification (HP:0002703)1.78474769
137Postnatal microcephaly (HP:0005484)1.75399527
138Tarsal synostosis (HP:0008368)1.75198461
139Aplasia cutis congenita (HP:0001057)1.74923560
140Bronchomalacia (HP:0002780)1.74677792
141Flared iliac wings (HP:0002869)1.73643596
142Hypoplastic toenails (HP:0001800)1.73463921
143Fragile nails (HP:0001808)1.73411391
144Melanocytic nevus (HP:0000995)1.73400076
145Parakeratosis (HP:0001036)1.72865559
146Osteolytic defects of the phalanges of the hand (HP:0009771)1.71977178
147Osteolytic defects of the hand bones (HP:0009699)1.71977178
148Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71011164
149Turricephaly (HP:0000262)1.70993978
150Preauricular skin tag (HP:0000384)1.70941350
151Abnormality of the acetabulum (HP:0003170)1.70715916
152Facial edema (HP:0000282)1.69286182
153Mesangial abnormality (HP:0001966)1.69070973
154Sparse eyelashes (HP:0000653)1.69052713
155Long palpebral fissure (HP:0000637)1.68984057
156Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.68664138
157Abnormal delivery (HP:0001787)1.68462175
158Broad face (HP:0000283)1.68139280
159Arterial thrombosis (HP:0004420)1.67916559
160Mild short stature (HP:0003502)1.66932674
161Abnormality of the calcaneus (HP:0008364)1.66540265
162Hypoventilation (HP:0002791)1.66132946
163Spinal rigidity (HP:0003306)1.65983492
164Mitral stenosis (HP:0001718)1.65107826
165Hematochezia (HP:0002573)1.64916458
166Breech presentation (HP:0001623)1.64343839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.40696713
2MST44.79953877
3LIMK14.63944704
4TRIB34.50770740
5FRK4.01068524
6PKN23.80679785
7IRAK33.63514802
8STK103.38364688
9GRK72.79489857
10LRRK22.67878512
11TAOK22.58048800
12TGFBR22.53085199
13MYLK2.41817320
14ABL22.14067108
15LATS22.10885172
16ALK2.04323837
17NME21.92198415
18TSSK61.75566795
19AKT31.70707305
20PRKG21.70204957
21PTK61.60102195
22EPHB11.56635973
23FER1.55642661
24PTK21.53396907
25RIPK11.48958414
26NTRK11.46092568
27PLK21.44294502
28PRPF4B1.41854234
29CDC42BPA1.40440767
30PAK21.35945262
31PIM21.33864684
32TESK11.32611135
33PAK31.31806055
34PDGFRA1.30931185
35RPS6KB21.30675081
36TYK21.27513185
37SIK11.27286164
38DDR21.27103798
39TRPM71.26582410
40TGFBR11.20415642
41TAOK11.17644871
42ERN11.17404829
43IKBKB1.11697103
44MAP3K81.11544037
45ERBB41.10650590
46IKBKE1.10159421
47KDR1.06815115
48ERBB31.05303407
49ROCK21.01613845
50STK241.00423489
51IRAK40.99332099
52PRKD20.98265431
53EEF2K0.97530642
54ADRBK20.96631326
55BLK0.96443188
56JAK10.93837844
57MAP3K130.93117037
58MAP2K10.92972997
59ROCK10.90826968
60MARK30.89750928
61PLK30.88199867
62KIT0.81954137
63NEK10.81093996
64MAP3K30.79408988
65MATK0.78700154
66DYRK30.76358078
67DAPK30.74284606
68PAK10.74156911
69MAPK70.73820573
70FGR0.73134173
71GRK50.72808172
72BRAF0.69404502
73IRAK10.68202473
74MAP3K10.68103728
75PTK2B0.68035790
76CLK10.67729828
77PAK40.67182319
78CHUK0.67114645
79ILK0.66744999
80SCYL20.65508660
81RAF10.65234976
82IRAK20.65085718
83PDPK10.64813731
84GSK3A0.63338693
85MAPKAPK30.62267865
86MET0.61981904
87MAP3K50.60920417
88STK380.59349741
89BMX0.59230173
90FLT30.58250208
91TESK20.56648978
92PDK10.56078224
93PAK60.55281277
94KSR20.55049649
95CDK60.54575787
96DMPK0.54285913
97MAPKAPK20.54125886
98TBK10.54116204
99NME10.52004719
100MELK0.51832157
101RPS6KL10.51473436
102RPS6KC10.51473436
103SRC0.49345571
104MAPK40.49233524
105MKNK10.48974268
106EPHB20.47984796
107TTN0.46561209
108MAP3K90.46103998
109PASK0.45979141
110CAMKK10.44999799
111MAP3K140.43498290
112ZAP700.42289518
113RPS6KA20.42070982
114MAP3K110.41445482
115EIF2AK10.40924290
116RET0.40609619
117LMTK20.40329419
118HIPK20.39574128
119PNCK0.39405846
120FGFR40.36658595
121MAP3K60.36558736
122PIK3CG0.35459188
123SMG10.35432391
124CSK0.34945457
125RPS6KA60.32941694
126NEK90.32812429
127PRKCI0.32360114
128ARAF0.30713827
129BTK0.30276516
130EPHA30.30136135
131PRKD10.29517591
132MTOR0.28857975
133BCR0.26525190
134MAP3K100.26207796
135ADRBK10.26162513
136LATS10.25453680
137JAK30.25214542
138RPS6KA40.24487150
139WEE10.23741438
140IGF1R0.23394151
141EGFR0.22860485
142HCK0.21740244
143MAP2K20.20646687
144MAP3K20.18842602
145MOS0.18795810
146EPHA20.17448225
147MAPKAPK50.16835961
148PIK3CA0.16680691
149CSNK1E0.16358707
150ABL10.15553661
151INSR0.15160755
152MAP2K30.14072089
153PDGFRB0.13892551

Predicted pathways (KEGG)

RankGene SetZ-score
1Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.98594141
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.94130368
3Other glycan degradation_Homo sapiens_hsa005112.85142080
4Linoleic acid metabolism_Homo sapiens_hsa005912.82465104
5ECM-receptor interaction_Homo sapiens_hsa045122.77487382
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.73516884
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.71658795
8Proteoglycans in cancer_Homo sapiens_hsa052052.40255700
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32858350
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.29036240
11Leukocyte transendothelial migration_Homo sapiens_hsa046702.28893387
12Antigen processing and presentation_Homo sapiens_hsa046122.25634539
13Focal adhesion_Homo sapiens_hsa045102.23821855
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.21411305
15Lysosome_Homo sapiens_hsa041422.09385944
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.08398079
17Dilated cardiomyopathy_Homo sapiens_hsa054142.02088620
18Pertussis_Homo sapiens_hsa051331.92295351
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.90753020
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81980978
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80810043
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76429448
23Adherens junction_Homo sapiens_hsa045201.76324772
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.73459517
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73348072
26African trypanosomiasis_Homo sapiens_hsa051431.67188461
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.59766337
28Shigellosis_Homo sapiens_hsa051311.57246706
29Arachidonic acid metabolism_Homo sapiens_hsa005901.55048110
30Bladder cancer_Homo sapiens_hsa052191.50160034
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48398068
32Acute myeloid leukemia_Homo sapiens_hsa052211.46356885
33Ether lipid metabolism_Homo sapiens_hsa005651.44270568
34Renal cell carcinoma_Homo sapiens_hsa052111.43358309
35MicroRNAs in cancer_Homo sapiens_hsa052061.40934300
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37882083
37Fat digestion and absorption_Homo sapiens_hsa049751.37825187
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33644286
39Viral myocarditis_Homo sapiens_hsa054161.29113520
40Tight junction_Homo sapiens_hsa045301.27822027
41Malaria_Homo sapiens_hsa051441.26650410
42Staphylococcus aureus infection_Homo sapiens_hsa051501.26386006
43Phagosome_Homo sapiens_hsa041451.25371954
44Tuberculosis_Homo sapiens_hsa051521.24100751
45Influenza A_Homo sapiens_hsa051641.22702274
46Small cell lung cancer_Homo sapiens_hsa052221.22306929
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.21181849
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19195818
49Protein digestion and absorption_Homo sapiens_hsa049741.16723373
50N-Glycan biosynthesis_Homo sapiens_hsa005101.16702407
51Dorso-ventral axis formation_Homo sapiens_hsa043201.13654850
52Axon guidance_Homo sapiens_hsa043601.12048861
53Osteoclast differentiation_Homo sapiens_hsa043801.10986441
54Platelet activation_Homo sapiens_hsa046111.09867281
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08347211
56Rap1 signaling pathway_Homo sapiens_hsa040151.08234375
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08151510
58Estrogen signaling pathway_Homo sapiens_hsa049151.05638371
59Salmonella infection_Homo sapiens_hsa051321.05539382
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05535777
61Sphingolipid metabolism_Homo sapiens_hsa006001.04888438
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.03985209
63Prostate cancer_Homo sapiens_hsa052151.03930292
64Hippo signaling pathway_Homo sapiens_hsa043901.03669494
65Complement and coagulation cascades_Homo sapiens_hsa046101.02469114
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99722288
67Mineral absorption_Homo sapiens_hsa049780.97860407
68TNF signaling pathway_Homo sapiens_hsa046680.95640799
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94117999
70VEGF signaling pathway_Homo sapiens_hsa043700.93102991
71Apoptosis_Homo sapiens_hsa042100.92534347
72TGF-beta signaling pathway_Homo sapiens_hsa043500.91525310
73Amoebiasis_Homo sapiens_hsa051460.91149106
74Measles_Homo sapiens_hsa051620.91014014
75Endometrial cancer_Homo sapiens_hsa052130.90513274
76Thyroid cancer_Homo sapiens_hsa052160.90178609
77Chronic myeloid leukemia_Homo sapiens_hsa052200.88477434
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88323314
79Legionellosis_Homo sapiens_hsa051340.87385221
80HIF-1 signaling pathway_Homo sapiens_hsa040660.85026749
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83603200
82Vibrio cholerae infection_Homo sapiens_hsa051100.82727837
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82679527
84Galactose metabolism_Homo sapiens_hsa000520.81231036
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81028067
86One carbon pool by folate_Homo sapiens_hsa006700.79832717
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.78827798
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76001554
89Protein export_Homo sapiens_hsa030600.75203518
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.74581457
91Nitrogen metabolism_Homo sapiens_hsa009100.72475362
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71229019
93Herpes simplex infection_Homo sapiens_hsa051680.70638738
94Pancreatic cancer_Homo sapiens_hsa052120.68733398
95Fructose and mannose metabolism_Homo sapiens_hsa000510.68626762
96Toxoplasmosis_Homo sapiens_hsa051450.66590186
97p53 signaling pathway_Homo sapiens_hsa041150.65020237
98Sulfur metabolism_Homo sapiens_hsa009200.64792889
99Ras signaling pathway_Homo sapiens_hsa040140.64095801
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62291996
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.61550603
102Endocytosis_Homo sapiens_hsa041440.60952393
103RNA transport_Homo sapiens_hsa030130.60002732
104Glioma_Homo sapiens_hsa052140.58476529
105Hepatitis B_Homo sapiens_hsa051610.58229463
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.57852039
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57177065
108Pathways in cancer_Homo sapiens_hsa052000.56392988
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55408182
110Viral carcinogenesis_Homo sapiens_hsa052030.54570932
111Notch signaling pathway_Homo sapiens_hsa043300.53514616
112Allograft rejection_Homo sapiens_hsa053300.53219515
113Prion diseases_Homo sapiens_hsa050200.52930886
114MAPK signaling pathway_Homo sapiens_hsa040100.51966368
115Thyroid hormone synthesis_Homo sapiens_hsa049180.50731476
116HTLV-I infection_Homo sapiens_hsa051660.50005230
117Choline metabolism in cancer_Homo sapiens_hsa052310.48988664
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.48653492
119FoxO signaling pathway_Homo sapiens_hsa040680.48063445
120Starch and sucrose metabolism_Homo sapiens_hsa005000.46717213
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45059974
122Gap junction_Homo sapiens_hsa045400.45013944
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44590552
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43342126
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42818115
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42449274
127Melanoma_Homo sapiens_hsa052180.41746352
128Graft-versus-host disease_Homo sapiens_hsa053320.39951830
129Renin-angiotensin system_Homo sapiens_hsa046140.39207632
130Ovarian steroidogenesis_Homo sapiens_hsa049130.39111177
131Rheumatoid arthritis_Homo sapiens_hsa053230.38760064
132GnRH signaling pathway_Homo sapiens_hsa049120.37718883
133Colorectal cancer_Homo sapiens_hsa052100.37657883
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35532719
135Prolactin signaling pathway_Homo sapiens_hsa049170.35380415
136Arginine and proline metabolism_Homo sapiens_hsa003300.34900286
137Phenylalanine metabolism_Homo sapiens_hsa003600.34628765
138Hepatitis C_Homo sapiens_hsa051600.31821307
139Chemokine signaling pathway_Homo sapiens_hsa040620.31458557
140Leishmaniasis_Homo sapiens_hsa051400.31246292
141Non-small cell lung cancer_Homo sapiens_hsa052230.29274394
142Hematopoietic cell lineage_Homo sapiens_hsa046400.29082136
143ErbB signaling pathway_Homo sapiens_hsa040120.28693233

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