ADM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid hormone metabolic process (GO:0042403)9.96784855
2protein retention in ER lumen (GO:0006621)7.02817300
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.84947719
4notochord development (GO:0030903)6.18751115
5exocrine pancreas development (GO:0031017)5.37168943
6sulfate transmembrane transport (GO:1902358)5.19224187
7peptidyl-proline hydroxylation (GO:0019511)5.11979831
8intestinal cholesterol absorption (GO:0030299)5.05583308
9cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.91656284
10mitotic metaphase plate congression (GO:0007080)4.89854955
11cell aggregation (GO:0098743)4.83442090
12cartilage condensation (GO:0001502)4.83442090
13COPI coating of Golgi vesicle (GO:0048205)4.68486989
14Golgi transport vesicle coating (GO:0048200)4.68486989
15sulfate transport (GO:0008272)4.68038432
16folic acid-containing compound biosynthetic process (GO:0009396)4.65541761
17regulation of female gonad development (GO:2000194)4.47586565
18proline biosynthetic process (GO:0006561)4.39771827
19regulation of apoptotic process involved in morphogenesis (GO:1902337)4.34499743
20keratan sulfate catabolic process (GO:0042340)4.28246963
21chondrocyte development (GO:0002063)4.28098839
22sulfur amino acid catabolic process (GO:0000098)4.24385697
23regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.22512003
24histone H2A monoubiquitination (GO:0035518)4.10447245
25protein hydroxylation (GO:0018126)4.04780517
26positive regulation of histone deacetylation (GO:0031065)4.00749932
27COPII vesicle coating (GO:0048208)3.99088058
28attachment of spindle microtubules to kinetochore (GO:0008608)3.91352607
29protein heterotrimerization (GO:0070208)3.89187705
30intestinal epithelial cell development (GO:0060576)3.87519081
31metaphase plate congression (GO:0051310)3.85760897
32piRNA metabolic process (GO:0034587)3.82374670
33negative regulation of smooth muscle cell differentiation (GO:0051151)3.82014302
344-hydroxyproline metabolic process (GO:0019471)3.80146777
35thyroid gland development (GO:0030878)3.77966839
36* digestion (GO:0007586)3.76729123
37nucleotide-sugar biosynthetic process (GO:0009226)3.73507999
38histone H2A ubiquitination (GO:0033522)3.68233845
39regulation of translational fidelity (GO:0006450)3.60773996
40negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.58933227
41one-carbon metabolic process (GO:0006730)3.50272599
42activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.44460292
43mitochondrial calcium ion transport (GO:0006851)3.44030932
44tetrahydrofolate metabolic process (GO:0046653)3.42201596
45sulfur compound transport (GO:0072348)3.39345643
46positive regulation of nuclease activity (GO:0032075)3.38493031
47L-serine transport (GO:0015825)3.32333763
48water-soluble vitamin biosynthetic process (GO:0042364)3.31480652
49endoplasmic reticulum unfolded protein response (GO:0030968)3.30454806
50maturation of 5.8S rRNA (GO:0000460)3.30125537
51behavioral response to nicotine (GO:0035095)3.28306543
52regulation of stem cell maintenance (GO:2000036)3.25615172
53positive regulation of hormone metabolic process (GO:0032352)3.25419053
54regulation of hippo signaling (GO:0035330)3.25174958
55intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.24354249
56establishment of chromosome localization (GO:0051303)3.24001906
57peptidyl-glutamic acid carboxylation (GO:0017187)3.23937839
58protein carboxylation (GO:0018214)3.23937839
59L-alpha-amino acid transmembrane transport (GO:1902475)3.22276847
60positive regulation of extracellular matrix organization (GO:1903055)3.22038880
61regulation of nuclease activity (GO:0032069)3.20999522
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.20911878
63cellular response to unfolded protein (GO:0034620)3.20469454
64negative regulation of keratinocyte proliferation (GO:0010839)3.18588467
65mitotic nuclear envelope disassembly (GO:0007077)3.18097882
66anterior/posterior axis specification, embryo (GO:0008595)3.16088798
67collagen fibril organization (GO:0030199)3.15037720
68negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.14746120
69serine family amino acid biosynthetic process (GO:0009070)3.13053373
70regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.12942644
71cellular response to topologically incorrect protein (GO:0035967)3.11511087
72GDP-mannose metabolic process (GO:0019673)3.10004600
73pteridine-containing compound biosynthetic process (GO:0042559)3.07879099
74ER-nucleus signaling pathway (GO:0006984)3.07740862
75regulation of gene silencing by RNA (GO:0060966)3.07406080
76regulation of posttranscriptional gene silencing (GO:0060147)3.07406080
77regulation of gene silencing by miRNA (GO:0060964)3.07406080
78regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.06259995
79regulation of keratinocyte proliferation (GO:0010837)3.05679770
80regulation of retinoic acid receptor signaling pathway (GO:0048385)3.05257999
81paraxial mesoderm development (GO:0048339)3.05026077
82citrulline biosynthetic process (GO:0019240)3.02367039
83regulation of transforming growth factor beta2 production (GO:0032909)3.01251753
84positive regulation of triglyceride biosynthetic process (GO:0010867)2.98926294
85protein localization to kinetochore (GO:0034501)2.98510126
86DNA strand renaturation (GO:0000733)2.98058703
87nuclear envelope disassembly (GO:0051081)2.98025159
88membrane disassembly (GO:0030397)2.98025159
89planar cell polarity pathway involved in neural tube closure (GO:0090179)2.97853093
90response to endoplasmic reticulum stress (GO:0034976)2.97764419
91basic amino acid transport (GO:0015802)2.97580071
92nodal signaling pathway (GO:0038092)2.95999147
93type B pancreatic cell development (GO:0003323)2.95811504
94meiotic cell cycle (GO:0051321)2.94267319
95establishment of apical/basal cell polarity (GO:0035089)2.92357490
96regulation of exit from mitosis (GO:0007096)2.91701582
97cell migration involved in gastrulation (GO:0042074)2.91341137
98female gamete generation (GO:0007292)2.89807117
99UDP-N-acetylglucosamine metabolic process (GO:0006047)2.89446087
100regulation of keratinocyte differentiation (GO:0045616)2.89170305
101establishment or maintenance of monopolar cell polarity (GO:0061339)2.88900236
102establishment of monopolar cell polarity (GO:0061162)2.88900236
103negative regulation of meiosis (GO:0045835)2.86121148
104mitotic chromosome condensation (GO:0007076)2.85562200
105negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.84855249
106protein complex localization (GO:0031503)2.84250312
107L-serine metabolic process (GO:0006563)2.83320834
108positive regulation of Cdc42 GTPase activity (GO:0043089)2.82816856
109proline metabolic process (GO:0006560)2.82714180
110intestinal absorption (GO:0050892)2.82580214
111zinc ion homeostasis (GO:0055069)2.79664488
112regulation of sister chromatid cohesion (GO:0007063)2.78631635
113folic acid-containing compound metabolic process (GO:0006760)2.77939728
114female gonad development (GO:0008585)2.77353053
115cellular response to gonadotropin stimulus (GO:0071371)2.75922760
116serine transport (GO:0032329)2.73976809
117protein maturation by protein folding (GO:0022417)2.73249162
118nucleotide transmembrane transport (GO:1901679)2.72098083
119cellular modified amino acid catabolic process (GO:0042219)2.72018291
120regulation of spindle organization (GO:0090224)2.71180746
121oocyte maturation (GO:0001556)2.70753974
122cellular response to ATP (GO:0071318)2.69620030
123hemidesmosome assembly (GO:0031581)2.69351199
124regulation of meiosis (GO:0040020)2.68627741
125homocysteine metabolic process (GO:0050667)2.66934816
126response to unfolded protein (GO:0006986)2.65846996
127negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.65812423
128cysteine metabolic process (GO:0006534)2.65679841
129ribosome assembly (GO:0042255)2.65678363
130cellular zinc ion homeostasis (GO:0006882)2.65675666
131negative regulation of telomere maintenance (GO:0032205)2.65470164
132negative regulation of signal transduction by p53 class mediator (GO:1901797)2.64799873
133regulation of integrin-mediated signaling pathway (GO:2001044)2.64372117
134regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63652703
135mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.63479221
136regulation of mesenchymal cell apoptotic process (GO:2001053)2.62699107
137establishment of planar polarity (GO:0001736)2.62603458
138establishment of tissue polarity (GO:0007164)2.62603458
139mitotic cell cycle arrest (GO:0071850)2.62376128
140regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.61647432
141serine family amino acid metabolic process (GO:0009069)2.61418132
142columnar/cuboidal epithelial cell development (GO:0002066)2.59807801
143response to gonadotropin (GO:0034698)2.59510619
144multicellular organismal catabolic process (GO:0044243)2.59371712
145polarized epithelial cell differentiation (GO:0030859)2.58970797
146formation of translation preinitiation complex (GO:0001731)2.58402761
147response to topologically incorrect protein (GO:0035966)2.58195269
148bone trabecula formation (GO:0060346)2.57735041
149DNA damage induced protein phosphorylation (GO:0006975)2.57056385
150negative regulation of reproductive process (GO:2000242)2.56959382
151fucosylation (GO:0036065)2.56062241
152ER overload response (GO:0006983)2.55123341
153amino acid activation (GO:0043038)2.54961606
154tRNA aminoacylation (GO:0043039)2.54961606
155cellular ketone body metabolic process (GO:0046950)2.54791382
156negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.54594582
157negative regulation of cell aging (GO:0090344)2.54487901
158regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52117023
159regulation of mesoderm development (GO:2000380)2.52094227
160tRNA aminoacylation for protein translation (GO:0006418)2.51561526
161maintenance of protein localization in organelle (GO:0072595)2.51234313
162positive regulation of protein kinase C signaling (GO:0090037)2.50928879
163meiotic chromosome segregation (GO:0045132)2.50525519
164amino acid transmembrane transport (GO:0003333)2.50016765
165positive regulation of fatty acid beta-oxidation (GO:0032000)2.49861304
166basement membrane organization (GO:0071711)2.48597417
167tRNA modification (GO:0006400)2.47897815
168neutral amino acid transport (GO:0015804)2.47392751
169biotin metabolic process (GO:0006768)2.45827079
170Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.45045678
171negative regulation of activin receptor signaling pathway (GO:0032926)2.43281429
172ketone body metabolic process (GO:1902224)2.40819405
173regulation of histone deacetylation (GO:0031063)2.40550476
174convergent extension (GO:0060026)2.40496837
175dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.40011760
176regulation of translational elongation (GO:0006448)2.39077471
177type B pancreatic cell proliferation (GO:0044342)2.38693987
178pteridine-containing compound metabolic process (GO:0042558)2.38143285
179positive regulation of protein deacetylation (GO:0090312)2.36763630
180zinc ion transmembrane transport (GO:0071577)2.36177474
181regulation of triglyceride biosynthetic process (GO:0010866)2.35459395
182nucleoside transmembrane transport (GO:1901642)2.34223146
183regulation of endothelial cell chemotaxis (GO:2001026)2.33123771
184L-fucose metabolic process (GO:0042354)2.32726508
185thyroid hormone generation (GO:0006590)12.2304992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.77115201
2E2F7_22180533_ChIP-Seq_HELA_Human4.52587866
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.13655042
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.71180585
5AR_21909140_ChIP-Seq_LNCAP_Human3.38910668
6ZNF263_19887448_ChIP-Seq_K562_Human3.14642485
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.01853319
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89035516
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.48213458
10RACK7_27058665_Chip-Seq_MCF-7_Human2.47960499
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37136424
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30125705
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.25494126
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.25419183
15LXR_22292898_ChIP-Seq_THP-1_Human2.23955616
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.21919474
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20843857
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.19153639
19* ATF3_27146783_Chip-Seq_COLON_Human2.18320372
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.16218320
21ERG_21242973_ChIP-ChIP_JURKAT_Human2.14749876
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14634891
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.11009037
24MYCN_18555785_ChIP-Seq_MESCs_Mouse2.10827266
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09314848
26DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.08779781
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.08552509
28P68_20966046_ChIP-Seq_HELA_Human2.02385029
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97424713
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.96074683
31TP53_22127205_ChIP-Seq_IMR90_Human1.92496613
32RARB_24833708_ChIP-Seq_LIVER_Mouse1.91977479
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91655095
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.90111469
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86927982
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82981238
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79832351
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75932694
39ZNF274_21170338_ChIP-Seq_K562_Hela1.75167399
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74095587
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72797778
42CTCF_27219007_Chip-Seq_Bcells_Human1.70945118
43FOXP1_21924763_ChIP-Seq_HESCs_Human1.70834556
44* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.70400189
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66040506
46CREB1_26743006_Chip-Seq_LNCaP_Human1.64917957
47RARA_24833708_ChIP-Seq_LIVER_Mouse1.64124796
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62184528
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60794604
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.59482412
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.58670582
52E2F1_20622854_ChIP-Seq_HELA_Human1.58130362
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.56625378
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54864540
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53334878
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.52427438
57PHF8_20622854_ChIP-Seq_HELA_Human1.51800918
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49289812
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48905680
60GABP_19822575_ChIP-Seq_HepG2_Human1.48328681
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46966752
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46966752
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46966752
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45771146
65SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.45545285
66GATA6_25053715_ChIP-Seq_YYC3_Human1.45155135
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44426859
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44217242
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.43590375
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42442997
71SMC4_20622854_ChIP-Seq_HELA_Human1.42227810
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42131501
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40731586
74CTCF_20526341_ChIP-Seq_ESCs_Human1.39973046
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39342834
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.38198079
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.36795989
78ERA_21632823_ChIP-Seq_H3396_Human1.36693455
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36261209
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.35715842
81DCP1A_22483619_ChIP-Seq_HELA_Human1.34664340
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.33971419
83YY1_22570637_ChIP-Seq_MALME-3M_Human1.32702224
84SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32233818
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31480482
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30485906
87TTF2_22483619_ChIP-Seq_HELA_Human1.30218349
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27882110
89KDM5A_27292631_Chip-Seq_BREAST_Human1.27583582
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27355894
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27158794
92BCOR_27268052_Chip-Seq_Bcells_Human1.26313721
93* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25848989
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24472479
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24347368
96FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22976519
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22872371
98RXR_22158963_ChIP-Seq_LIVER_Mouse1.22344428
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22081902
100BCL6_27268052_Chip-Seq_Bcells_Human1.21376961
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.20951249
102EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19138585
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.17233241
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16488399
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16255417
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15637126
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14166742
108STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13890141
109XRN2_22483619_ChIP-Seq_HELA_Human1.13545796
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12900310
111GATA4_25053715_ChIP-Seq_YYC3_Human1.12849375
112EGR1_19374776_ChIP-ChIP_THP-1_Human1.12842427
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.12671219
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12062479
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11659410
116TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.11648464
117TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11374461
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11035136
119VDR_23849224_ChIP-Seq_CD4+_Human1.11020584
120CHD1_26751641_Chip-Seq_LNCaP_Human1.11001567
121SA1_27219007_Chip-Seq_Bcells_Human1.10864441
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09391897
123TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09344468
124GATA3_24758297_ChIP-Seq_MCF-7_Human1.08806620
125NOTCH1_21737748_ChIP-Seq_TLL_Human1.08027968
126MYC_22102868_ChIP-Seq_BL_Human1.07770575
127VDR_21846776_ChIP-Seq_THP-1_Human1.07036379
128STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05811912
129RUNX1_27514584_Chip-Seq_MCF-7_Human1.05714689
130CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05111313
131NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04031611
132RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03429577
133FLI1_21867929_ChIP-Seq_CD8_Mouse1.01757118
134SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01631386
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01503497
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01413565
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01255355
138P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00656434
139P53_21459846_ChIP-Seq_SAOS-2_Human1.00136080
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00126541
141MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99507749
142TP53_20018659_ChIP-ChIP_R1E_Mouse0.99138467
143SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97563192
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.97426781
145TFEB_21752829_ChIP-Seq_HELA_Human0.96470456
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96434963
147* TP63_22573176_ChIP-Seq_HFKS_Human0.96405545
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96217029
149MAF_26560356_Chip-Seq_TH2_Human0.94695053
150PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94429439
151MYC_18940864_ChIP-ChIP_HL60_Human0.94014467
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94001401
153TET1_21490601_ChIP-Seq_MESCs_Mouse0.93959523
154CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93879566
155ERG_20517297_ChIP-Seq_VCAP_Human0.93858234
156ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93837989
157SRF_21415370_ChIP-Seq_HL-1_Mouse0.93317548
158KAP1_27257070_Chip-Seq_ESCs_Mouse0.93297153
159SOX2_20726797_ChIP-Seq_SW620_Human0.93248836
160E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92866852
161ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92803307
162UBF1/2_26484160_Chip-Seq_HMECs_Human0.92723173
163STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92126550
164MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90137083
165GATA1_26923725_Chip-Seq_HPCs_Mouse0.89654408
166SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86256021
167TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86071040
168TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85770489
169CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85341525
170CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84827966
171CTCF_21964334_Chip-Seq_Bcells_Human0.82740837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology4.34229807
2MP0003646_muscle_fatigue3.53362290
3MP0000681_abnormal_thyroid_gland3.48960250
4MP0003693_abnormal_embryo_hatching3.35749292
5MP0005220_abnormal_exocrine_pancreas3.24819514
6MP0003718_maternal_effect3.01807215
7MP0001666_abnormal_nutrient_absorption2.73349694
8MP0005083_abnormal_biliary_tract2.71727604
9MP0000383_abnormal_hair_follicle2.66800173
10MP0008875_abnormal_xenobiotic_pharmacok2.66457747
11MP0000566_synostosis2.49565632
12MP0002282_abnormal_trachea_morphology2.39365977
13MP0004957_abnormal_blastocyst_morpholog2.39311270
14MP0003123_paternal_imprinting2.31319273
15MP0004858_abnormal_nervous_system2.31165994
16MP0005451_abnormal_body_composition2.21221852
17MP0000163_abnormal_cartilage_morphology2.17510127
18MP0004134_abnormal_chest_morphology2.14524180
19MP0009250_abnormal_appendicular_skeleto2.07318079
20MP0004133_heterotaxia1.98998071
21MP0005503_abnormal_tendon_morphology1.95366295
22MP0004272_abnormal_basement_membrane1.94801538
23MP0002933_joint_inflammation1.93943017
24MP0003705_abnormal_hypodermis_morpholog1.92436923
25MP0003937_abnormal_limbs/digits/tail_de1.92387900
26MP0010678_abnormal_skin_adnexa1.92377591
27MP0002877_abnormal_melanocyte_morpholog1.92355180
28MP0000538_abnormal_urinary_bladder1.91680220
29MP0005257_abnormal_intraocular_pressure1.88742611
30MP0005171_absent_coat_pigmentation1.85972094
31MP0003077_abnormal_cell_cycle1.82587332
32MP0009384_cardiac_valve_regurgitation1.81356695
33MP0004885_abnormal_endolymph1.76949276
34MP0002254_reproductive_system_inflammat1.73939558
35MP0002115_abnormal_skeleton_extremities1.73335711
36MP0000372_irregular_coat_pigmentation1.72013493
37MP0003868_abnormal_feces_composition1.70023609
38MP0004264_abnormal_extraembryonic_tissu1.68018587
39MP0003111_abnormal_nucleus_morphology1.67777912
40MP0002653_abnormal_ependyma_morphology1.62671663
41MP0003283_abnormal_digestive_organ1.61501772
42MP0002060_abnormal_skin_morphology1.58174361
43MP0002113_abnormal_skeleton_development1.51310853
44MP0000762_abnormal_tongue_morphology1.51178756
45MP0005508_abnormal_skeleton_morphology1.49811755
46MP0008932_abnormal_embryonic_tissue1.49546594
47MP0010234_abnormal_vibrissa_follicle1.48067173
48MP0001958_emphysema1.46586055
49MP0003279_aneurysm1.44933381
50MP0002896_abnormal_bone_mineralization1.40928120
51MP0010094_abnormal_chromosome_stability1.39457609
52MP0005395_other_phenotype1.39418138
53MP0003136_yellow_coat_color1.39175402
54MP0003755_abnormal_palate_morphology1.38870881
55MP0009840_abnormal_foam_cell1.36348381
56MP0005075_abnormal_melanosome_morpholog1.35745862
57MP0002109_abnormal_limb_morphology1.35511969
58MP0010030_abnormal_orbit_morphology1.35214846
59MP0001299_abnormal_eye_distance/1.35028775
60MP0003941_abnormal_skin_development1.34754882
61MP0005501_abnormal_skin_physiology1.32855342
62MP0002938_white_spotting1.32625266
63MP0003890_abnormal_embryonic-extraembry1.31622050
64MP0010771_integument_phenotype1.31117462
65MP0005365_abnormal_bile_salt1.31070837
66MP0000678_abnormal_parathyroid_gland1.31067634
67MP0010352_gastrointestinal_tract_polyps1.30221723
68MP0008007_abnormal_cellular_replicative1.30005807
69MP0000432_abnormal_head_morphology1.28411816
70MP0004043_abnormal_pH_regulation1.25794042
71MP0001485_abnormal_pinna_reflex1.25793374
72MP0001346_abnormal_lacrimal_gland1.25286509
73MP0001119_abnormal_female_reproductive1.24823084
74MP0002693_abnormal_pancreas_physiology1.22929768
75MP0000462_abnormal_digestive_system1.22787703
76MP0003119_abnormal_digestive_system1.21632080
77MP0004233_abnormal_muscle_weight1.20946528
78MP0000350_abnormal_cell_proliferation1.20686465
79MP0002089_abnormal_postnatal_growth/wei1.20297241
80MP0000613_abnormal_salivary_gland1.16973825
81MP0002116_abnormal_craniofacial_bone1.16039166
82MP0005023_abnormal_wound_healing1.14572518
83MP0003566_abnormal_cell_adhesion1.14371224
84MP0003795_abnormal_bone_structure1.13791334
85MP0003656_abnormal_erythrocyte_physiolo1.12415751
86MP0002084_abnormal_developmental_patter1.12236236
87MP0002160_abnormal_reproductive_system1.11502658
88MP0002111_abnormal_tail_morphology1.10978392
89MP0003699_abnormal_female_reproductive1.10490515
90MP0002085_abnormal_embryonic_tissue1.10326938
91MP0005360_urolithiasis1.08567538
92MP0005076_abnormal_cell_differentiation1.08242853
93MP0002249_abnormal_larynx_morphology1.08113706
94MP0001697_abnormal_embryo_size1.07782527
95MP0001730_embryonic_growth_arrest1.05924478
96MP0002932_abnormal_joint_morphology1.04412454
97MP0008877_abnormal_DNA_methylation1.03753830
98MP0008438_abnormal_cutaneous_collagen1.03543028
99MP0001348_abnormal_lacrimal_gland1.03514101
100MP0000427_abnormal_hair_cycle1.02283644
101MP0008004_abnormal_stomach_pH1.00811801
102MP0003787_abnormal_imprinting1.00438774
103MP0004742_abnormal_vestibular_system0.99342163
104MP0002098_abnormal_vibrissa_morphology0.99222614
105MP0000653_abnormal_sex_gland0.98950218
106MP0005084_abnormal_gallbladder_morpholo0.98842789
107MP0005390_skeleton_phenotype0.97096398
108MP0000377_abnormal_hair_follicle0.96962308
109MP0001944_abnormal_pancreas_morphology0.96716528
110MP0000371_diluted_coat_color0.95775331
111MP0002210_abnormal_sex_determination0.95246303
112MP0001672_abnormal_embryogenesis/_devel0.95207631
113MP0005380_embryogenesis_phenotype0.95207631
114MP0001873_stomach_inflammation0.95036823
115MP0004185_abnormal_adipocyte_glucose0.92207441
116MP0001542_abnormal_bone_strength0.91396918
117MP0002234_abnormal_pharynx_morphology0.91363400
118MP0004381_abnormal_hair_follicle0.91279372
119MP0000003_abnormal_adipose_tissue0.90469324
120MP0001919_abnormal_reproductive_system0.90440117
121MP0003935_abnormal_craniofacial_develop0.90228638
122MP0005275_abnormal_skin_tensile0.88369875
123MP0000750_abnormal_muscle_regeneration0.88070617
124MP0000470_abnormal_stomach_morphology0.86520625
125MP0004147_increased_porphyrin_level0.86257791
126MP0005408_hypopigmentation0.86119399
127MP0001929_abnormal_gametogenesis0.85943759
128MP0005174_abnormal_tail_pigmentation0.85684071
129MP0005621_abnormal_cell_physiology0.85516769
130MP0002138_abnormal_hepatobiliary_system0.84254963
131MP0001661_extended_life_span0.83403518
132MP0000579_abnormal_nail_morphology0.82484334
133MP0000367_abnormal_coat/_hair0.81749294
134MP0000049_abnormal_middle_ear0.80828711
135MP0002233_abnormal_nose_morphology0.80647352
136MP0001502_abnormal_circadian_rhythm0.79001057
137MP0002114_abnormal_axial_skeleton0.78690629
138MP0005381_digestive/alimentary_phenotyp0.78121619
139MP0004197_abnormal_fetal_growth/weight/0.77833846
140MP0005377_hearing/vestibular/ear_phenot0.77662387
141MP0003878_abnormal_ear_physiology0.77662387
142MP0001145_abnormal_male_reproductive0.77596573
143MP0003942_abnormal_urinary_system0.77319085
144MP0000467_abnormal_esophagus_morphology0.77301385
145MP0003959_abnormal_lean_body0.76002884
146MP0003936_abnormal_reproductive_system0.75947350
147MP0005332_abnormal_amino_acid0.75841469
148MP0005551_abnormal_eye_electrophysiolog0.75701304
149MP0001243_abnormal_dermal_layer0.75513270
150MP0001188_hyperpigmentation0.74925660
151MP0002075_abnormal_coat/hair_pigmentati0.74887977
152MP0004019_abnormal_vitamin_homeostasis0.69848259
153MP0000534_abnormal_ureter_morphology0.69642125
154MP0002295_abnormal_pulmonary_circulatio0.67816604
155MP0000026_abnormal_inner_ear0.67021280
156MP0005197_abnormal_uvea_morphology0.66817281
157MP0002796_impaired_skin_barrier0.65936564
158MP0002163_abnormal_gland_morphology0.65898125
159MP0009643_abnormal_urine_homeostasis0.65339679
160MP0001881_abnormal_mammary_gland0.62288649
161MP0001324_abnormal_eye_pigmentation0.62173482

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)8.70894335
2Epiphyseal dysplasia (HP:0002656)8.19358877
3Vitreoretinal degeneration (HP:0000655)6.96371692
4Hypoplastic ischia (HP:0003175)6.13653755
5Small epiphyses (HP:0010585)5.86711923
6Flat capital femoral epiphysis (HP:0003370)5.78425762
7Abnormality of the ischium (HP:0003174)5.49886293
8Goiter (HP:0000853)5.46570303
9Cupped ribs (HP:0000887)5.29249589
10Abnormal tarsal ossification (HP:0008369)4.98574325
11Thyroid-stimulating hormone excess (HP:0002925)4.89136897
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.64781250
13Flat acetabular roof (HP:0003180)4.63157040
14Genu varum (HP:0002970)4.61760690
15Delayed epiphyseal ossification (HP:0002663)4.60303447
16Abnormality of femoral epiphyses (HP:0006499)4.36236458
17Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.36236458
18Metaphyseal cupping (HP:0003021)4.16526909
19Flattened epiphyses (HP:0003071)4.11577310
20Pili torti (HP:0003777)3.98858235
21Abnormality of the epiphysis of the femoral head (HP:0010574)3.95214588
22Premature rupture of membranes (HP:0001788)3.93035705
23Carpal bone hypoplasia (HP:0001498)3.84127601
24Abnormality of the vertebral endplates (HP:0005106)3.76924238
25Abnormal foot bone ossification (HP:0010675)3.76552300
26Abnormality of the femoral head (HP:0003368)3.61147764
27Mild short stature (HP:0003502)3.60344764
28Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.59809482
29Absent epiphyses (HP:0010577)3.59809482
30Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)3.56616982
31Congenital sensorineural hearing impairment (HP:0008527)3.56365922
32Cervical subluxation (HP:0003308)3.38752744
33Short femoral neck (HP:0100864)3.32636994
34Osteoarthritis (HP:0002758)3.30878012
35Congenital stationary night blindness (HP:0007642)3.28444614
36Testicular atrophy (HP:0000029)3.27662426
37Irregular vertebral endplates (HP:0003301)3.24946816
38Abnormality of the proximal phalanges of the hand (HP:0009834)3.22231988
39Hyperthyroidism (HP:0000836)3.16999764
40Breast hypoplasia (HP:0003187)3.12310989
41Neonatal short-limb short stature (HP:0008921)3.10872437
42Protrusio acetabuli (HP:0003179)3.09085955
43Abnormal hair laboratory examination (HP:0003328)3.07403323
44Metaphyseal irregularity (HP:0003025)3.07243943
45Arthropathy (HP:0003040)3.02699346
46Pterygium (HP:0001059)2.99540085
47Thin ribs (HP:0000883)2.96364579
48Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.96180494
49Rib fusion (HP:0000902)2.94066132
50Coxa vara (HP:0002812)2.92910408
51Metaphyseal dysplasia (HP:0100255)2.90489241
52Soft skin (HP:0000977)2.89065255
53Stillbirth (HP:0003826)2.84526181
54Vertebral clefting (HP:0008428)2.80352487
55Platyspondyly (HP:0000926)2.75357824
56Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.74418559
57Long clavicles (HP:0000890)2.73220209
58Cortical dysplasia (HP:0002539)2.73178572
59Hypoplasia of the odontoid process (HP:0003311)2.72709027
60Beaking of vertebral bodies (HP:0004568)2.70389428
61Abnormality of the pubic bones (HP:0003172)2.70288728
62Ankle contracture (HP:0006466)2.69838654
63Protuberant abdomen (HP:0001538)2.69804743
64Abnormal vertebral ossification (HP:0100569)2.69095457
65Enlarged epiphyses (HP:0010580)2.68430538
66Barrel-shaped chest (HP:0001552)2.64588538
67Bladder diverticulum (HP:0000015)2.63821165
68Shallow orbits (HP:0000586)2.63744838
69Abnormality of dentin (HP:0010299)2.58245677
70Fragile skin (HP:0001030)2.57437003
71Attenuation of retinal blood vessels (HP:0007843)2.57054559
72Disproportionate short-trunk short stature (HP:0003521)2.53971802
73Joint stiffness (HP:0001387)2.48899597
74Mesangial abnormality (HP:0001966)2.47685116
75Thoracolumbar scoliosis (HP:0002944)2.47148244
76Coronal craniosynostosis (HP:0004440)2.44885820
77Abnormality of the phalanges of the 2nd finger (HP:0009541)2.42475394
78Abnormality of cochlea (HP:0000375)2.41497915
79Sparse lateral eyebrow (HP:0005338)2.39693504
80Waddling gait (HP:0002515)2.37616698
81Hypoplasia of the pons (HP:0012110)2.36412329
82Aplasia/hypoplasia of the femur (HP:0005613)2.35939472
83Atrophic scars (HP:0001075)2.34014393
84Thin bony cortex (HP:0002753)2.33086802
85Limited elbow extension (HP:0001377)2.32403236
86Patellar aplasia (HP:0006443)2.32293810
87Abnormality of the odontoid process (HP:0003310)2.30311954
88Follicular hyperkeratosis (HP:0007502)2.29886629
89Premature skin wrinkling (HP:0100678)2.26636561
90Concave nail (HP:0001598)2.26204637
91Vertebral hypoplasia (HP:0008417)2.26010087
92Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.26010087
93Hypothermia (HP:0002045)2.25894649
94Slender long bone (HP:0003100)2.24945438
95Aplasia/Hypoplasia of the patella (HP:0006498)2.24559331
96Morphological abnormality of the middle ear (HP:0008609)2.24352194
97Bowed forearm bones (HP:0003956)2.23221683
98Bowing of the arm (HP:0006488)2.23221683
99Aplasia of the musculature (HP:0100854)2.22507084
100Genu recurvatum (HP:0002816)2.22112236
101Male infertility (HP:0003251)2.22085119
102Redundant skin (HP:0001582)2.20847035
103Hip contracture (HP:0003273)2.20283442
104Bronchomalacia (HP:0002780)2.18855520
105Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.17823866
106Exostoses (HP:0100777)2.17364520
107Ovoid vertebral bodies (HP:0003300)2.17241295
108Biconcave vertebral bodies (HP:0004586)2.15182165
109Abnormality of carpal bone ossification (HP:0006257)2.14436399
110Abnormality of the pons (HP:0007361)2.12594530
111Morphological abnormality of the inner ear (HP:0011390)2.12119529
112Hypoplastic pelvis (HP:0008839)2.10434137
113Broad metatarsal (HP:0001783)2.10096181
114Blue sclerae (HP:0000592)2.08717682
115Squamous cell carcinoma (HP:0002860)2.08518017
116Nonimmune hydrops fetalis (HP:0001790)2.05628436
117Birth length less than 3rd percentile (HP:0003561)2.05420320
118Abnormality of the phalanges of the 5th finger (HP:0004213)2.02976880
119Glossoptosis (HP:0000162)2.02745624
120Abnormality of the acetabulum (HP:0003170)2.02683537
121Hypoplastic ilia (HP:0000946)2.02123669
122Aplasia/Hypoplasia involving the vertebral column (HP:0008518)2.01484447
123Absent frontal sinuses (HP:0002688)2.01111053
124Abnormality of incisor morphology (HP:0011063)1.99782021
125Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.98010105
126Spinal cord compression (HP:0002176)1.97167982
127Limited hip movement (HP:0008800)1.95816882
128Coxa valga (HP:0002673)1.92576961
129Vaginal fistula (HP:0004320)1.91727391
130Ulnar deviation of the wrist (HP:0003049)1.91642293
131Bowel diverticulosis (HP:0005222)1.88636446
132Severe short stature (HP:0003510)1.81970322
133Pendular nystagmus (HP:0012043)1.81653090
134Ulnar bowing (HP:0003031)1.81307488
135Radial bowing (HP:0002986)1.81164310
136Hyperacusis (HP:0010780)1.81002515
137Abnormality of the vitreous humor (HP:0004327)1.80739789
138Abnormal hand bone ossification (HP:0010660)1.80520757
139Patent foramen ovale (HP:0001655)1.79809304
140Abnormality of proline metabolism (HP:0010907)1.79568337
141Hydroxyprolinuria (HP:0003080)1.79568337
142Abnormal albumin level (HP:0012116)1.78245924
143Hypoalbuminemia (HP:0003073)1.78245924
144Hypoplastic nipples (HP:0002557)1.77056515
145Hand muscle atrophy (HP:0009130)1.75802143
146Hypoplastic iliac wings (HP:0002866)1.75698061
147Tubular atrophy (HP:0000092)1.74704941
148Broad phalanx (HP:0006009)1.73444608
149Abnormality of the calcaneus (HP:0008364)1.72889408
150Abnormality of the aortic arch (HP:0012303)1.72172049
151Genu valgum (HP:0002857)1.72107013
152Adrenal hypoplasia (HP:0000835)1.71368187
153Long palpebral fissure (HP:0000637)1.71175919
154Femoral bowing (HP:0002980)1.70551934
155Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70503509
156Elbow flexion contracture (HP:0002987)1.70102177
157Stridor (HP:0010307)1.69730196
158Aplasia/Hypoplasia of the scapulae (HP:0006713)1.68924962
159Hypoplastic scapulae (HP:0000882)1.68924962
160Abnormality of the 2nd finger (HP:0004100)1.68812987
161Abnormal ossification of hand bones (HP:0005921)1.67508775
162Broad long bones (HP:0005622)1.65697474
163Poikiloderma (HP:0001029)1.65540223
164Fibular hypoplasia (HP:0003038)1.64872318
165Lumbar hyperlordosis (HP:0002938)1.64439557
166Short ribs (HP:0000773)1.64036170
167Prolonged partial thromboplastin time (HP:0003645)1.63581305
168Hypothyroidism (HP:0000821)1.63138422
169Aortic regurgitation (HP:0001659)1.63071307
170Renal duplication (HP:0000075)1.62945365
171Hypokinesia (HP:0002375)1.60421706
172Infantile muscular hypotonia (HP:0008947)1.59981184
173Ketoacidosis (HP:0001993)1.59912711
174Upper limb muscle weakness (HP:0003484)1.59281385
175Tracheal stenosis (HP:0002777)1.57155805
176Aortic dissection (HP:0002647)1.55956746
177Choanal stenosis (HP:0000452)1.55833298
178Hyperextensible skin (HP:0000974)1.52588691
179Aplasia/Hypoplasia involving the musculature (HP:0001460)1.52470428
180Amelogenesis imperfecta (HP:0000705)1.52389272
181Popliteal pterygium (HP:0009756)1.49689821
182Increased corneal curvature (HP:0100692)1.47534106
183Keratoconus (HP:0000563)1.47534106
184Coarse facial features (HP:0000280)1.46690721
185Hyperglycinuria (HP:0003108)1.46335627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS25.06255820
2LATS14.50313938
3STK38L3.99088602
4WNK43.78417995
5DDR23.02317076
6AKT33.00709433
7SMG12.95262570
8SIK12.80905074
9INSRR2.79229049
10ERBB42.64995211
11MAP3K32.63531490
12VRK22.60395233
13MAP3K62.59891176
14TAF12.55814312
15MST1R2.50630266
16MAPK152.36450353
17EPHA22.32611870
18TAOK32.25076247
19GRK12.22055264
20ADRBK22.17200207
21EEF2K2.15564322
22PRKD32.08263651
23NME12.07370104
24BCKDK2.05546903
25ERN12.05154269
26MAPKAPK31.97395058
27PLK41.95092528
28TTK1.92089829
29MAP2K61.82657386
30STK391.75255668
31MOS1.74287411
32TLK11.65621432
33EIF2AK11.65393876
34EIF2AK31.64576132
35FGFR41.61618726
36KSR21.60504663
37STK31.59448923
38CDC71.58199374
39TRIB31.52808733
40BRAF1.43137669
41CDK81.38828615
42DYRK21.37606970
43LMTK21.37091433
44RPS6KB21.35765679
45STK241.35365042
46TAOK11.33840703
47PKN21.30074566
48STK101.26806477
49MAP3K81.25559896
50IRAK31.23452359
51MAP3K91.20805221
52CAMK1D1.19823669
53TAOK21.19418116
54RPS6KA41.17767700
55MELK1.12447032
56NLK1.12044639
57TSSK61.06365849
58PRKG21.04993735
59MAP3K131.04796690
60PLK11.03324465
61NTRK10.99109372
62PDGFRA0.96834199
63BRSK20.96822149
64FGFR20.94758842
65PLK30.93719275
66BMPR1B0.93529176
67ICK0.93508585
68NEK20.93119572
69TRPM70.91657759
70NUAK10.91257307
71CDK90.90513391
72RAF10.89342682
73BUB10.89125284
74EPHA30.88231142
75AURKB0.87281538
76TRIM280.84130206
77CHEK20.83949186
78PTK20.83013588
79ILK0.81047860
80ARAF0.80142960
81ACVR1B0.79511281
82MUSK0.78804164
83ADRBK10.78000496
84MAP2K20.76058347
85EPHB20.74836518
86TXK0.74584184
87MAP4K20.74193411
88PTK60.73768382
89RPS6KA20.72348049
90MET0.71123298
91MST40.71123288
92KIT0.71033841
93FRK0.71008400
94ZAK0.69959461
95AURKA0.69369738
96MYLK0.66464982
97DYRK30.64350425
98DYRK1A0.63091081
99PRKCH0.62993306
100MAP2K10.62930709
101FLT30.62922512
102PASK0.62136661
103NME20.62078751
104ABL20.61906086
105NEK90.61149762
106CAMK1G0.60587107
107CHEK10.60372953
108SCYL20.58243581
109RET0.57758751
110TYRO30.55557642
111MTOR0.52523967
112PRKCI0.51788947
113BMPR20.50805349
114CDK120.49981027
115CDK70.49638995
116NEK10.48771777
117CHUK0.48733031
118MAPK110.48385090
119WEE10.47611823
120IRAK10.45906842
121PRKD20.43273567
122MAP3K50.42682601
123BRSK10.42462178
124KSR10.42364684
125PIM10.41048503
126RPS6KA60.40302714
127PLK20.39824613
128DYRK1B0.39737494
129MAPKAPK50.37688884
130ATM0.37338140
131GSK3A0.37268631
132CDC42BPA0.36624968
133PAK10.36367688
134OXSR10.35497624
135TGFBR10.32933273
136IKBKB0.31592951
137VRK10.31427269
138MAPK80.31112062
139PAK40.30305769
140PAK30.29843023
141FER0.29151129
142DAPK30.28994779
143PAK20.28867160
144PIM20.28222079
145PTK2B0.28089970
146CDK20.27899489
147HIPK20.27124923
148PRKAA10.26935721
149ATR0.26836106
150ERBB30.26105567
151BMX0.25282236
152ABL10.24526147
153MAP3K10.24400659
154MAPK10.23661696
155CDK10.22914850
156PRKAA20.22088861
157CSNK1E0.21755340

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein digestion and absorption_Homo sapiens_hsa049744.44783800
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.52191238
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.46561913
4Thyroid hormone synthesis_Homo sapiens_hsa049183.22587766
5Pancreatic secretion_Homo sapiens_hsa049723.10611573
6One carbon pool by folate_Homo sapiens_hsa006703.06636200
7Protein export_Homo sapiens_hsa030603.04860274
8Folate biosynthesis_Homo sapiens_hsa007902.52713835
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.51590231
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.47725561
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47325376
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39123689
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.33096543
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32648807
15ECM-receptor interaction_Homo sapiens_hsa045122.27793070
16Fat digestion and absorption_Homo sapiens_hsa049752.26098533
17Cell cycle_Homo sapiens_hsa041102.22140108
18RNA transport_Homo sapiens_hsa030132.19487323
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.19280171
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09031027
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06562814
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03652191
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.01909582
24RNA degradation_Homo sapiens_hsa030181.88040338
25Sulfur relay system_Homo sapiens_hsa041221.80266804
26p53 signaling pathway_Homo sapiens_hsa041151.75676576
27Basal transcription factors_Homo sapiens_hsa030221.75658912
28Linoleic acid metabolism_Homo sapiens_hsa005911.75390030
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71105922
30RNA polymerase_Homo sapiens_hsa030201.70765795
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.49140282
32Other glycan degradation_Homo sapiens_hsa005111.46717093
33Biosynthesis of amino acids_Homo sapiens_hsa012301.46674187
34TGF-beta signaling pathway_Homo sapiens_hsa043501.46609759
35Steroid biosynthesis_Homo sapiens_hsa001001.45731899
36Lysine degradation_Homo sapiens_hsa003101.44119758
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41555784
38Bladder cancer_Homo sapiens_hsa052191.40640537
39Arginine and proline metabolism_Homo sapiens_hsa003301.37930145
40Vitamin B6 metabolism_Homo sapiens_hsa007501.36195509
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33200769
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33115072
43Fructose and mannose metabolism_Homo sapiens_hsa000511.30167973
44Selenocompound metabolism_Homo sapiens_hsa004501.28847753
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20114173
46Arginine biosynthesis_Homo sapiens_hsa002201.20013782
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19861382
48Pancreatic cancer_Homo sapiens_hsa052121.17729656
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.14921198
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14477945
51Ovarian steroidogenesis_Homo sapiens_hsa049131.13870048
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11265773
53Sphingolipid metabolism_Homo sapiens_hsa006001.09923970
54Hippo signaling pathway_Homo sapiens_hsa043901.06161058
55Phototransduction_Homo sapiens_hsa047441.05413249
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03480187
57Arachidonic acid metabolism_Homo sapiens_hsa005901.02936768
58Adherens junction_Homo sapiens_hsa045201.02375135
59ABC transporters_Homo sapiens_hsa020101.01179236
60Tyrosine metabolism_Homo sapiens_hsa003500.95180121
61Circadian rhythm_Homo sapiens_hsa047100.92934649
62Butanoate metabolism_Homo sapiens_hsa006500.91375417
63MicroRNAs in cancer_Homo sapiens_hsa052060.90926773
64Base excision repair_Homo sapiens_hsa034100.88798196
65Nucleotide excision repair_Homo sapiens_hsa034200.87926183
66Focal adhesion_Homo sapiens_hsa045100.86006893
67DNA replication_Homo sapiens_hsa030300.84888713
68Small cell lung cancer_Homo sapiens_hsa052220.83396276
69Homologous recombination_Homo sapiens_hsa034400.82727085
70Thyroid cancer_Homo sapiens_hsa052160.81325621
71mTOR signaling pathway_Homo sapiens_hsa041500.79621605
72Histidine metabolism_Homo sapiens_hsa003400.74498873
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74340261
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74110592
75Pyruvate metabolism_Homo sapiens_hsa006200.72212679
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71686967
77Pyrimidine metabolism_Homo sapiens_hsa002400.71021474
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68488972
79Sulfur metabolism_Homo sapiens_hsa009200.67839589
80Insulin resistance_Homo sapiens_hsa049310.67583338
81Mismatch repair_Homo sapiens_hsa034300.66349088
82Ether lipid metabolism_Homo sapiens_hsa005650.65814821
83Metabolic pathways_Homo sapiens_hsa011000.65544303
84Glycerolipid metabolism_Homo sapiens_hsa005610.65315924
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65202472
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64994851
87Autoimmune thyroid disease_Homo sapiens_hsa053200.64046802
88Prostate cancer_Homo sapiens_hsa052150.64031139
89Melanoma_Homo sapiens_hsa052180.63531632
90Mineral absorption_Homo sapiens_hsa049780.63404174
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61430243
92mRNA surveillance pathway_Homo sapiens_hsa030150.60359222
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60351939
94Glutathione metabolism_Homo sapiens_hsa004800.59530985
95Vitamin digestion and absorption_Homo sapiens_hsa049770.58463581
96HIF-1 signaling pathway_Homo sapiens_hsa040660.56195271
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54045822
98Tryptophan metabolism_Homo sapiens_hsa003800.53700600
99HTLV-I infection_Homo sapiens_hsa051660.53327089
100Oocyte meiosis_Homo sapiens_hsa041140.53259422
101Spliceosome_Homo sapiens_hsa030400.52389468
102Fanconi anemia pathway_Homo sapiens_hsa034600.50853580
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49738406
104Non-homologous end-joining_Homo sapiens_hsa034500.49493294
105Viral carcinogenesis_Homo sapiens_hsa052030.48345745
106N-Glycan biosynthesis_Homo sapiens_hsa005100.48232165
107Proteasome_Homo sapiens_hsa030500.47725738
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46937449
109Colorectal cancer_Homo sapiens_hsa052100.46662542
110Epstein-Barr virus infection_Homo sapiens_hsa051690.45131376
111Endometrial cancer_Homo sapiens_hsa052130.42248069
112Proteoglycans in cancer_Homo sapiens_hsa052050.40801466
113Apoptosis_Homo sapiens_hsa042100.40508308
114Fatty acid biosynthesis_Homo sapiens_hsa000610.39236351
115Basal cell carcinoma_Homo sapiens_hsa052170.37141650
116Caffeine metabolism_Homo sapiens_hsa002320.36811182
117FoxO signaling pathway_Homo sapiens_hsa040680.36482547
118Wnt signaling pathway_Homo sapiens_hsa043100.36364723
119Galactose metabolism_Homo sapiens_hsa000520.35836194
120Prolactin signaling pathway_Homo sapiens_hsa049170.34880490
121Hepatitis B_Homo sapiens_hsa051610.34001014
122Nitrogen metabolism_Homo sapiens_hsa009100.32358456
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31454981
124VEGF signaling pathway_Homo sapiens_hsa043700.31063857
125Fatty acid metabolism_Homo sapiens_hsa012120.30842922
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30745702
127Hedgehog signaling pathway_Homo sapiens_hsa043400.29671669
128Purine metabolism_Homo sapiens_hsa002300.29381968
129Tight junction_Homo sapiens_hsa045300.27783318
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.27014970
131Notch signaling pathway_Homo sapiens_hsa043300.26222519
132Chronic myeloid leukemia_Homo sapiens_hsa052200.26216391
133Pathways in cancer_Homo sapiens_hsa052000.25638445
134Influenza A_Homo sapiens_hsa051640.24935694
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.24653056
136Melanogenesis_Homo sapiens_hsa049160.24597656
137Glucagon signaling pathway_Homo sapiens_hsa049220.23778856
138Starch and sucrose metabolism_Homo sapiens_hsa005000.23468680
139Shigellosis_Homo sapiens_hsa051310.23440621
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23402240
141Choline metabolism in cancer_Homo sapiens_hsa052310.23139027
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.22302109
143AMPK signaling pathway_Homo sapiens_hsa041520.21582090
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21292014

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