ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	7.48109277
2	viral transcription (GO:0019083)	6.06203748
3	translational termination (GO:0006415)	5.76660231
4	DNA strand renaturation (GO:0000733)	5.20275413
5	translational elongation (GO:0006414)	5.12480513
6	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	5.08903869
7	GDP-mannose metabolic process (GO:0019673)	4.99035351
8	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.85011077
9	DNA replication checkpoint (GO:0000076)	4.76081883
10	viral life cycle (GO:0019058)	4.64824580
11	cellular protein complex disassembly (GO:0043624)	4.48184816
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.46931058
13	ribosomal small subunit assembly (GO:0000028)	4.41176831
14	meiotic chromosome segregation (GO:0045132)	4.39470701
15	protein targeting to ER (GO:0045047)	4.33746723
16	cotranslational protein targeting to membrane (GO:0006613)	4.33383638
17	ribonucleoprotein complex biogenesis (GO:0022613)	4.31442481
18	protein complex disassembly (GO:0043241)	4.27575838
19	adenine nucleotide transport (GO:0051503)	4.22561846
20	rRNA modification (GO:0000154)	4.20286297
21	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.12406220
22	negative regulation of cell aging (GO:0090344)	4.08942400
23	cellular response to ATP (GO:0071318)	4.07894735
24	protein localization to endoplasmic reticulum (GO:0070972)	4.05526757
25	translational initiation (GO:0006413)	4.03722708
26	ribosomal large subunit biogenesis (GO:0042273)	4.03118554
27	macromolecular complex disassembly (GO:0032984)	3.98226351
28	maturation of SSU-rRNA (GO:0030490)	3.93157100
29	rRNA methylation (GO:0031167)	3.86964715
30	formation of translation preinitiation complex (GO:0001731)	3.72832228
31	L-serine metabolic process (GO:0006563)	3.68561788
32	UV protection (GO:0009650)	3.67287956
33	purine ribonucleotide transport (GO:0015868)	3.55503570
34	pseudouridine synthesis (GO:0001522)	3.55160821
35	base-excision repair, AP site formation (GO:0006285)	3.54636784
36	positive regulation of protein kinase C signaling (GO:0090037)	3.45850897
37	ribosome biogenesis (GO:0042254)	3.40802784
38	tRNA modification (GO:0006400)	3.37273384
39	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.36709833
40	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.33948734
41	heterochromatin organization (GO:0070828)	3.33272502
42	regulation of translational fidelity (GO:0006450)	3.31071584
43	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.30259566
44	hypothalamus development (GO:0021854)	3.29152286
45	post-embryonic morphogenesis (GO:0009886)	3.28681717
46	rRNA transcription (GO:0009303)	3.27455477
47	cellular component biogenesis (GO:0044085)	3.27110482
48	mRNA catabolic process (GO:0006402)	3.25408496
49	purine nucleotide transport (GO:0015865)	3.23626242
50	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.23459234
51	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.20793651
52	protein-DNA complex disassembly (GO:0032986)	3.18384893
53	nucleosome disassembly (GO:0006337)	3.18384893
54	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.17193320
55	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	3.16265946
56	DNA duplex unwinding (GO:0032508)	3.14041331
57	DNA unwinding involved in DNA replication (GO:0006268)	3.11310353
58	RNA catabolic process (GO:0006401)	3.10657258
59	UTP biosynthetic process (GO:0006228)	3.10572981
60	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.08270559
61	sex determination (GO:0007530)	3.01675173
62	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.00060907
63	DNA strand elongation involved in DNA replication (GO:0006271)	3.00051272
64	DNA geometric change (GO:0032392)	2.99908348
65	rRNA processing (GO:0006364)	2.99421416
66	protein targeting to membrane (GO:0006612)	2.99239694
67	telomere maintenance via semi-conservative replication (GO:0032201)	2.98940504
68	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.98295706
69	folic acid metabolic process (GO:0046655)	2.95764000
70	adenosine receptor signaling pathway (GO:0001973)	2.95015234
71	DNA strand elongation (GO:0022616)	2.94579236
72	mitotic G1 DNA damage checkpoint (GO:0031571)	2.93874146
73	translation (GO:0006412)	2.93245368
74	pyrimidine nucleotide catabolic process (GO:0006244)	2.92830231
75	regulation of mitochondrial translation (GO:0070129)	2.91008070
76	cellular response to virus (GO:0098586)	2.89978455
77	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.88710229
78	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.87205116
79	ncRNA 3-end processing (GO:0043628)	2.87057334
80	G1 DNA damage checkpoint (GO:0044783)	2.84540069
81	rRNA metabolic process (GO:0016072)	2.84474042
82	chromatin assembly (GO:0031497)	2.83801311
83	positive regulation by host of viral transcription (GO:0043923)	2.83184892
84	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.77765127
85	UMP biosynthetic process (GO:0006222)	2.77765127
86	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.77765127
87	UMP metabolic process (GO:0046049)	2.77765127
88	positive regulation of T cell apoptotic process (GO:0070234)	2.77102190
89	phosphatidylglycerol biosynthetic process (GO:0006655)	2.74868365
90	mitotic G1/S transition checkpoint (GO:0044819)	2.73113792
91	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.72843775
92	behavioral response to nicotine (GO:0035095)	2.71910726
93	protein insertion into membrane (GO:0051205)	2.71085681
94	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.70413482
95	tRNA methylation (GO:0030488)	2.70223743
96	proline biosynthetic process (GO:0006561)	2.69660109
97	negative regulation of RNA splicing (GO:0033119)	2.69649174
98	UTP metabolic process (GO:0046051)	2.69586327
99	DNA replication initiation (GO:0006270)	2.69041825
100	sensory perception of taste (GO:0050909)	2.68315643

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_21846776_ChIP-Seq_THP-1_Human	3.56434462
2	MYC_22102868_ChIP-Seq_BL_Human	3.18136135
3	E2F7_22180533_ChIP-Seq_HELA_Human	2.94463511
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.92792328
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.83368091
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.52407141
7	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.47043170
8	XRN2_22483619_ChIP-Seq_HELA_Human	2.45267228
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.35924825
10	LXR_22292898_ChIP-Seq_THP-1_Human	2.27836507
11	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.21504144
12	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.20549567
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.17844224
14	P68_20966046_ChIP-Seq_HELA_Human	2.10538689
15	CIITA_25753668_ChIP-Seq_RAJI_Human	2.03599986
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.88871801
17	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.83651668
18	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.83110955
19	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.80664699
20	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.77490918
21	MAF_26560356_Chip-Seq_TH2_Human	1.77334723
22	DCP1A_22483619_ChIP-Seq_HELA_Human	1.76050456
23	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.75102264
24	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.75059234
25	GABP_19822575_ChIP-Seq_HepG2_Human	1.74643270
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.70356255
27	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.67651360
28	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.66668004
29	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.64785380
30	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.62428557
31	RACK7_27058665_Chip-Seq_MCF-7_Human	1.60189360
32	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.59113908
33	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.55654393
34	ZNF263_19887448_ChIP-Seq_K562_Human	1.55434254
35	KDM5A_27292631_Chip-Seq_BREAST_Human	1.53024239
36	VDR_24763502_ChIP-Seq_THP-1_Human	1.52617880
37	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.52102409
38	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.51278358
39	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.51098983
40	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.50781863
41	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.50742766
42	KDM2B_26808549_Chip-Seq_DND41_Human	1.50632431
43	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.48607534
44	TTF2_22483619_ChIP-Seq_HELA_Human	1.48191938
45	BCL6_27268052_Chip-Seq_Bcells_Human	1.48145414
46	CTCF_27219007_Chip-Seq_Bcells_Human	1.47854584
47	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.46369000
48	MAF_26560356_Chip-Seq_TH1_Human	1.43316513
49	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.43192406
50	TCF7_22412390_ChIP-Seq_EML_Mouse	1.43066859
51	BCOR_27268052_Chip-Seq_Bcells_Human	1.41384511
52	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.40276852
53	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.39356015
54	SMC4_20622854_ChIP-Seq_HELA_Human	1.39106992
55	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.38233574
56	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.38057718
57	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.37053475
58	FOXP3_21729870_ChIP-Seq_TREG_Human	1.35782257
59	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.34645180
60	E2F1_20622854_ChIP-Seq_HELA_Human	1.34162963
61	PHF8_20622854_ChIP-Seq_HELA_Human	1.34120851
62	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.31952637
63	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.30643359
64	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.28810924
65	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.26418296
66	UTX_26944678_Chip-Seq_JUKART_Human	1.24374308
67	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.24162604
68	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.22309247
69	CTCF_21964334_Chip-Seq_Bcells_Human	1.22264506
70	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.22030236
71	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.21523901
72	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.21444649
73	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.21431792
74	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.20695957
75	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.20408092
76	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.19078467
77	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.18933638
78	CREB1_26743006_Chip-Seq_LNCaP_Human	1.18781964
79	NCOR1_26117541_ChIP-Seq_K562_Human	1.18527242
80	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.18153729
81	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.18136631
82	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.17307017
83	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.17214077
84	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.17155677
85	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.16704700
86	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.16164002
87	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.13953280
88	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.13901567
89	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13799225
90	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.13444894
91	SA1_27219007_Chip-Seq_Bcells_Human	1.12037864
92	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.10780844
93	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.10574140
94	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.10076699
95	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.09830640
96	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.09565235
97	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.08995271
98	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.08046857
99	KDM2B_26808549_Chip-Seq_K562_Human	1.08021308
100	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.06520917

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005423_abnormal_somatic_nervous	4.12662724
2	MP0003123_paternal_imprinting	4.12173116
3	MP0003693_abnormal_embryo_hatching	4.09252084
4	MP0001986_abnormal_taste_sensitivity	4.02258143
5	MP0003136_yellow_coat_color	3.73798791
6	MP0003111_abnormal_nucleus_morphology	3.70595007
7	MP0005174_abnormal_tail_pigmentation	2.88480165
8	MP0004957_abnormal_blastocyst_morpholog	2.75843149
9	MP0005171_absent_coat_pigmentation	2.57427904
10	MP0005409_darkened_coat_color	2.42311382
11	MP0001188_hyperpigmentation	2.24119363
12	MP0010094_abnormal_chromosome_stability	2.16168588
13	MP0003787_abnormal_imprinting	2.15332163
14	MP0000003_abnormal_adipose_tissue	2.09201163
15	MP0002163_abnormal_gland_morphology	2.02880656
16	MP0005076_abnormal_cell_differentiation	1.99632716
17	MP0004381_abnormal_hair_follicle	1.90565380
18	MP0001348_abnormal_lacrimal_gland	1.84217126
19	MP0001968_abnormal_touch/_nociception	1.83328467
20	MP0000015_abnormal_ear_pigmentation	1.69727980
21	MP0003077_abnormal_cell_cycle	1.68380499
22	MP0003315_abnormal_perineum_morphology	1.67541328
23	MP0001661_extended_life_span	1.66208401
24	MP0009379_abnormal_foot_pigmentation	1.61873891
25	MP0006292_abnormal_olfactory_placode	1.61723643
26	MP0005451_abnormal_body_composition	1.58351153
27	MP0008058_abnormal_DNA_repair	1.46376381
28	MP0001873_stomach_inflammation	1.39332557
29	MP0005084_abnormal_gallbladder_morpholo	1.32945600
30	MP0005220_abnormal_exocrine_pancreas	1.32130934
31	MP0005083_abnormal_biliary_tract	1.32069990
32	MP0002396_abnormal_hematopoietic_system	1.31525940
33	MP0003763_abnormal_thymus_physiology	1.30147854
34	MP0000350_abnormal_cell_proliferation	1.27484134
35	MP0001919_abnormal_reproductive_system	1.26591220
36	MP0001502_abnormal_circadian_rhythm	1.26241937
37	MP0003172_abnormal_lysosome_physiology	1.24068044
38	MP0005377_hearing/vestibular/ear_phenot	1.23408784
39	MP0003878_abnormal_ear_physiology	1.23408784
40	MP0002019_abnormal_tumor_incidence	1.20133633
41	MP0009333_abnormal_splenocyte_physiolog	1.19749147
42	MP0008932_abnormal_embryonic_tissue	1.19255077
43	MP0000678_abnormal_parathyroid_gland	1.14930239
44	MP0004185_abnormal_adipocyte_glucose	1.14115978
45	MP0000013_abnormal_adipose_tissue	1.11060742
46	MP0000703_abnormal_thymus_morphology	1.09052680
47	MP0003786_premature_aging	1.08858797
48	MP0003303_peritoneal_inflammation	1.06646374
49	MP0005501_abnormal_skin_physiology	1.06506167
50	MP0002736_abnormal_nociception_after	1.05918105
51	MP0000313_abnormal_cell_death	1.02477551
52	MP0009278_abnormal_bone_marrow	1.00847370
53	MP0005375_adipose_tissue_phenotype	1.00653244
54	MP0002080_prenatal_lethality	1.00504789
55	MP0001730_embryonic_growth_arrest	0.99415755
56	MP0002160_abnormal_reproductive_system	0.99317358
57	MP0008995_early_reproductive_senescence	0.98551838
58	MP0000631_abnormal_neuroendocrine_gland	0.96304192
59	MP0003121_genomic_imprinting	0.92868188
60	MP0003806_abnormal_nucleotide_metabolis	0.92537193
61	MP0002210_abnormal_sex_determination	0.91142123
62	MP0002398_abnormal_bone_marrow	0.91057819
63	MP0008007_abnormal_cellular_replicative	0.90103046
64	MP0008961_abnormal_basal_metabolism	0.89084742
65	MP0002138_abnormal_hepatobiliary_system	0.88010797
66	MP0001697_abnormal_embryo_size	0.87938859
67	MP0002822_catalepsy	0.87831399
68	MP0001756_abnormal_urination	0.85769721
69	MP0000470_abnormal_stomach_morphology	0.83610665
70	MP0001672_abnormal_embryogenesis/_devel	0.83115716
71	MP0005380_embryogenesis_phenotype	0.83115716
72	MP0003453_abnormal_keratinocyte_physiol	0.82679396
73	MP0003984_embryonic_growth_retardation	0.79963648
74	MP0002429_abnormal_blood_cell	0.79666441
75	MP0004197_abnormal_fetal_growth/weight/	0.78925262
76	MP0000358_abnormal_cell_content/	0.76334405
77	MP0009672_abnormal_birth_weight	0.76165434
78	MP0002088_abnormal_embryonic_growth/wei	0.75882314
79	MP0003011_delayed_dark_adaptation	0.75646893
80	MP0001944_abnormal_pancreas_morphology	0.75521336
81	MP0008057_abnormal_DNA_replication	0.75417896
82	MP0002249_abnormal_larynx_morphology	0.75379917
83	MP0004808_abnormal_hematopoietic_stem	0.71282958
84	MP0005389_reproductive_system_phenotype	0.71139709
85	MP0005058_abnormal_lysosome_morphology	0.70854250
86	MP0002722_abnormal_immune_system	0.70624330
87	MP0005379_endocrine/exocrine_gland_phen	0.68812616
88	MP0002085_abnormal_embryonic_tissue	0.68631224
89	MP0000750_abnormal_muscle_regeneration	0.68156138
90	MP0001270_distended_abdomen	0.67713573
91	MP0001145_abnormal_male_reproductive	0.67659878
92	MP0005645_abnormal_hypothalamus_physiol	0.66376292
93	MP0004130_abnormal_muscle_cell	0.63132289
94	MP0003942_abnormal_urinary_system	0.61765294
95	MP0000716_abnormal_immune_system	0.59686271
96	MP0002086_abnormal_extraembryonic_tissu	0.58820553
97	MP0001905_abnormal_dopamine_level	0.57546891
98	MP0003705_abnormal_hypodermis_morpholog	0.56875774
99	MP0002735_abnormal_chemical_nociception	0.55521431
100	MP0005666_abnormal_adipose_tissue	0.55354781

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rib fusion (HP:0000902)	4.90104915
2	Poikiloderma (HP:0001029)	4.81092408
3	Annular pancreas (HP:0001734)	4.66614211
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.64914807
5	Testicular atrophy (HP:0000029)	4.63415178
6	Facial hemangioma (HP:0000329)	4.56108934
7	Abnormal number of erythroid precursors (HP:0012131)	4.34060345
8	Squamous cell carcinoma (HP:0002860)	4.23979225
9	Hyperthyroidism (HP:0000836)	3.99578918
10	Patellar aplasia (HP:0006443)	3.70885113
11	Thin bony cortex (HP:0002753)	3.60796854
12	Intestinal fistula (HP:0100819)	3.51699173
13	Aplasia/Hypoplasia of the patella (HP:0006498)	3.46563743
14	Rectovaginal fistula (HP:0000143)	3.43150732
15	Rectal fistula (HP:0100590)	3.43150732
16	Vaginal fistula (HP:0004320)	3.36303226
17	Birth length less than 3rd percentile (HP:0003561)	3.15988649
18	Ulnar bowing (HP:0003031)	3.11737637
19	Absent thumb (HP:0009777)	2.96721634
20	Breast hypoplasia (HP:0003187)	2.95481810
21	Septo-optic dysplasia (HP:0100842)	2.81704450
22	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.80831371
23	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.80719721
24	Pallor (HP:0000980)	2.77234132
25	Progressive muscle weakness (HP:0003323)	2.75930296
26	Turricephaly (HP:0000262)	2.75107186
27	Bony spicule pigmentary retinopathy (HP:0007737)	2.65967841
28	Premature graying of hair (HP:0002216)	2.64699139
29	Macrocytic anemia (HP:0001972)	2.63033526
30	Truncus arteriosus (HP:0001660)	2.61082318
31	Neoplasm of the adrenal cortex (HP:0100641)	2.55958683
32	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.52772644
33	Microvesicular hepatic steatosis (HP:0001414)	2.51937790
34	Delayed epiphyseal ossification (HP:0002663)	2.51698335
35	Pointed chin (HP:0000307)	2.39307716
36	Hyperacusis (HP:0010780)	2.36720845
37	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.31054516
38	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.27451230
39	Spina bifida occulta (HP:0003298)	2.27237844
40	Reticulocytopenia (HP:0001896)	2.27095188
41	Congenital stationary night blindness (HP:0007642)	2.26065783
42	J-shaped sella turcica (HP:0002680)	2.23778047
43	Basal cell carcinoma (HP:0002671)	2.23214194
44	Anteriorly placed anus (HP:0001545)	2.20944526
45	Short chin (HP:0000331)	2.20773432
46	Abnormality of DNA repair (HP:0003254)	2.19051926
47	Hypertensive crisis (HP:0100735)	2.05320832
48	Villous atrophy (HP:0011473)	2.04557488
49	Abnormality of small intestinal villus morphology (HP:0011472)	2.04557488
50	Hypoplasia of the pons (HP:0012110)	2.04407732
51	Bowed forearm bones (HP:0003956)	2.02639696
52	Bowing of the arm (HP:0006488)	2.02639696
53	Absent epiphyses (HP:0010577)	2.02461561
54	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.02461561
55	Abnormal trabecular bone morphology (HP:0100671)	1.98844390
56	Broad distal phalanx of finger (HP:0009836)	1.98042716
57	Capillary hemangiomas (HP:0005306)	1.97649581
58	Thrombocytosis (HP:0001894)	1.95574158
59	Flat occiput (HP:0005469)	1.95550570
60	Progressive external ophthalmoplegia (HP:0000590)	1.94895532
61	Overlapping toe (HP:0001845)	1.94326084
62	Hypoplasia of the radius (HP:0002984)	1.93875306
63	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.93454542
64	Seborrheic dermatitis (HP:0001051)	1.93355091
65	Increased intramyocellular lipid droplets (HP:0012240)	1.88808561
66	Myopathic facies (HP:0002058)	1.86475606
67	Asymmetry of the thorax (HP:0001555)	1.84005339
68	Attenuation of retinal blood vessels (HP:0007843)	1.82666061
69	Rectal prolapse (HP:0002035)	1.81874386
70	Short thumb (HP:0009778)	1.79550937
71	Increased muscle lipid content (HP:0009058)	1.78547429
72	Rough bone trabeculation (HP:0100670)	1.75619578
73	Abnormality of the pons (HP:0007361)	1.75182617
74	Prolonged partial thromboplastin time (HP:0003645)	1.74643163
75	External ophthalmoplegia (HP:0000544)	1.74614373
76	Widely patent fontanelles and sutures (HP:0004492)	1.74229437
77	Slender long bone (HP:0003100)	1.74150628
78	Self-mutilation (HP:0000742)	1.73543700
79	Achilles tendon contracture (HP:0001771)	1.73205419
80	Optic nerve coloboma (HP:0000588)	1.73146367
81	Panhypogammaglobulinemia (HP:0003139)	1.70792497
82	Deep palmar crease (HP:0006191)	1.69842989
83	Abnormal number of incisors (HP:0011064)	1.64096113
84	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.63307154
85	Homocystinuria (HP:0002156)	1.60980222
86	Abnormality of homocysteine metabolism (HP:0010919)	1.60980222
87	Myelodysplasia (HP:0002863)	1.60478213
88	Hypoalbuminemia (HP:0003073)	1.60371536
89	Abnormal albumin level (HP:0012116)	1.60371536
90	Abnormality of the thoracic spine (HP:0100711)	1.57034490
91	Hemorrhage of the eye (HP:0011885)	1.56672475
92	Abnormality of the intrinsic pathway (HP:0010989)	1.54443467
93	Supernumerary nipples (HP:0002558)	1.54142213
94	Ketosis (HP:0001946)	1.54126973
95	Atresia of the external auditory canal (HP:0000413)	1.54068721
96	Nasolacrimal duct obstruction (HP:0000579)	1.53829063
97	Bowel incontinence (HP:0002607)	1.52315574
98	11 pairs of ribs (HP:0000878)	1.52241948
99	Easy fatigability (HP:0003388)	1.51761735
100	Cerebellar dysplasia (HP:0007033)	1.51232913

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	4.98393734
2	SMG1	4.12827387
3	SIK1	3.72547477
4	EEF2K	2.93415895
5	ICK	2.78192650
6	MAP3K10	2.76140927
7	NME2	2.42966205
8	STK16	2.37842280
9	BCKDK	2.28691392
10	PRPF4B	2.24534501
11	PRKD3	2.04690746
12	MAPK15	2.03986930
13	CDK12	2.03699322
14	RPS6KB2	1.93634152
15	SIK2	1.91849049
16	MAP4K1	1.88246234
17	TLK1	1.84199076
18	ZAK	1.74640208
19	ERN1	1.61945412
20	WNK4	1.59291487
21	VRK2	1.46355681
22	CDC7	1.40397884
23	LRRK2	1.29450028
24	IRAK2	1.27066318
25	CDK4	1.26753525
26	CDK7	1.25363482
27	CAMK1D	1.19718504
28	MAP3K11	1.14285310
29	PASK	1.14111389
30	GRK6	1.13269947
31	CDK19	1.12190675
32	BTK	1.09286916
33	MAPK11	1.08587071
34	IRAK3	1.07805313
35	MTOR	1.05497557
36	CHEK2	1.05429742
37	TESK2	1.03870115
38	DMPK	1.02264908
39	BUB1	0.96144578
40	CDK8	0.94967805
41	DYRK1B	0.94639224
42	MAP2K2	0.94225793
43	ARAF	0.93114213
44	DYRK2	0.91173467
45	AURKA	0.89183190
46	PIM2	0.88907382
47	RPS6KA2	0.87641259
48	SIK3	0.85855525
49	ATR	0.85432842
50	RPS6KL1	0.84961182
51	RPS6KC1	0.84961182
52	PLK1	0.79384351
53	DYRK3	0.79291324
54	RPS6KA6	0.78176560
55	RPS6KA4	0.78163998
56	RAF1	0.75811916
57	MARK2	0.75759574
58	CAMKK1	0.74123733
59	DAPK1	0.71230471
60	TAOK2	0.70522026
61	ILK	0.69448810
62	TNK2	0.68054752
63	CDK9	0.67897389
64	HIPK2	0.66816983
65	PKN2	0.66711617
66	KDR	0.64135472
67	PRKCI	0.63634685
68	NUAK1	0.61089355
69	CHEK1	0.58895952
70	CDK2	0.58840324
71	CDK11A	0.56961307
72	ZAP70	0.55913154
73	RPS6KA5	0.54755281
74	MAP2K6	0.53908613
75	AKT2	0.52855121
76	PDPK1	0.52800194
77	RPS6KA1	0.52784787
78	TBK1	0.52529422
79	AURKB	0.49749695
80	NME1	0.48845644
81	MAP3K8	0.47733431
82	MAPKAPK3	0.46578483
83	CDK1	0.46392381
84	BLK	0.45653503
85	MAP2K3	0.44543244
86	PIM1	0.43690302
87	TAF1	0.43674064
88	CDK15	0.41420471
89	IKBKB	0.40667703
90	TTK	0.40453630
91	BRAF	0.40047656
92	MAPK12	0.39695628
93	MUSK	0.38663056
94	CAMK1G	0.37772713
95	PRKAA1	0.37481900
96	WNK1	0.37400384
97	MELK	0.36981211
98	MAPK8	0.36749362
99	PRKD2	0.36522856
100	MARK3	0.34520294

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	5.21297626
2	Ribosome_Homo sapiens_hsa03010	4.98351042
3	DNA replication_Homo sapiens_hsa03030	3.60919631
4	Base excision repair_Homo sapiens_hsa03410	3.12286471
5	RNA polymerase_Homo sapiens_hsa03020	2.81523066
6	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.64820275
7	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.52539592
8	Pyrimidine metabolism_Homo sapiens_hsa00240	2.36911772
9	Homologous recombination_Homo sapiens_hsa03440	2.31028085
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.26088491
11	Mismatch repair_Homo sapiens_hsa03430	2.13204823
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.09899196
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.09558729
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.97974318
15	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.83529743
16	Other glycan degradation_Homo sapiens_hsa00511	1.76230983
17	Spliceosome_Homo sapiens_hsa03040	1.68949263
18	One carbon pool by folate_Homo sapiens_hsa00670	1.64206375
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.60898092
20	Notch signaling pathway_Homo sapiens_hsa04330	1.52331050
21	Cell cycle_Homo sapiens_hsa04110	1.48082960
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.47774713
23	mRNA surveillance pathway_Homo sapiens_hsa03015	1.47274052
24	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.44617867
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.43930907
26	RNA transport_Homo sapiens_hsa03013	1.40024990
27	Bladder cancer_Homo sapiens_hsa05219	1.23541640
28	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.19486340
29	Asthma_Homo sapiens_hsa05310	1.17479492
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.16453985
31	Lysine degradation_Homo sapiens_hsa00310	1.16099199
32	VEGF signaling pathway_Homo sapiens_hsa04370	1.15389739
33	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.11388885
34	Acute myeloid leukemia_Homo sapiens_hsa05221	1.09437275
35	Non-small cell lung cancer_Homo sapiens_hsa05223	1.08585739
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.07577355
37	HTLV-I infection_Homo sapiens_hsa05166	1.01767510
38	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.99294586
39	Primary immunodeficiency_Homo sapiens_hsa05340	0.94650157
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.94281625
41	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.93696911
42	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.81223541
43	Purine metabolism_Homo sapiens_hsa00230	0.81146277
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75413467
45	Basal cell carcinoma_Homo sapiens_hsa05217	0.75145717
46	Herpes simplex infection_Homo sapiens_hsa05168	0.73933930
47	Endometrial cancer_Homo sapiens_hsa05213	0.71085704
48	Pentose phosphate pathway_Homo sapiens_hsa00030	0.70498802
49	Basal transcription factors_Homo sapiens_hsa03022	0.70189400
50	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.69282346
51	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.68270561
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.65891432
53	Allograft rejection_Homo sapiens_hsa05330	0.63849113
54	RNA degradation_Homo sapiens_hsa03018	0.63276702
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.62789121
56	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.62291558
57	mTOR signaling pathway_Homo sapiens_hsa04150	0.60820380
58	p53 signaling pathway_Homo sapiens_hsa04115	0.59962514
59	Folate biosynthesis_Homo sapiens_hsa00790	0.57604547
60	Thyroid cancer_Homo sapiens_hsa05216	0.57286749
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.54843154
62	Huntingtons disease_Homo sapiens_hsa05016	0.52825646
63	Parkinsons disease_Homo sapiens_hsa05012	0.52295348
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.52022169
65	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.49882686
66	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.49707002
67	Proteasome_Homo sapiens_hsa03050	0.48627867
68	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.45518138
69	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.45444424
70	Colorectal cancer_Homo sapiens_hsa05210	0.45119314
71	Oxidative phosphorylation_Homo sapiens_hsa00190	0.44768055
72	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.44524082
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43420447
74	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.43175887
75	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.42481299
76	Pancreatic cancer_Homo sapiens_hsa05212	0.41098281
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.39800092
78	Insulin signaling pathway_Homo sapiens_hsa04910	0.39663030
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.38809233
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37625280
81	Graft-versus-host disease_Homo sapiens_hsa05332	0.37453271
82	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.36563965
83	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.35805533
84	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.34383119
85	Influenza A_Homo sapiens_hsa05164	0.33728381
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.29993087
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.29971598
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.29801499
89	Metabolic pathways_Homo sapiens_hsa01100	0.28881355
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28878676
91	Apoptosis_Homo sapiens_hsa04210	0.28769804
92	Hepatitis B_Homo sapiens_hsa05161	0.28237732
93	AMPK signaling pathway_Homo sapiens_hsa04152	0.28231017
94	Carbon metabolism_Homo sapiens_hsa01200	0.28043673
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.27005700
96	Small cell lung cancer_Homo sapiens_hsa05222	0.23600245
97	Viral carcinogenesis_Homo sapiens_hsa05203	0.21832684
98	Hepatitis C_Homo sapiens_hsa05160	0.20665619
99	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.20436532
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.19904392

ADM5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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