ADNP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.60462330
2limb bud formation (GO:0060174)4.17387711
3histone H3-K4 trimethylation (GO:0080182)4.12133935
4lateral sprouting from an epithelium (GO:0060601)3.81183731
5negative regulation of translation, ncRNA-mediated (GO:0040033)3.78007679
6regulation of translation, ncRNA-mediated (GO:0045974)3.78007679
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.78007679
8mitotic sister chromatid cohesion (GO:0007064)3.77842862
9negative regulation of DNA-dependent DNA replication (GO:2000104)3.76583250
10DNA double-strand break processing (GO:0000729)3.75845207
11regulation of centriole replication (GO:0046599)3.68843846
12replication fork processing (GO:0031297)3.66693473
13histone H3-K4 methylation (GO:0051568)3.43357560
14synapsis (GO:0007129)3.42909094
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.42573777
16mitochondrial DNA replication (GO:0006264)3.41567066
17histone H2A acetylation (GO:0043968)3.36578759
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.30070611
19definitive hemopoiesis (GO:0060216)3.23870570
20sister chromatid cohesion (GO:0007062)3.23719019
21response to pheromone (GO:0019236)3.14433058
22somite development (GO:0061053)3.13315951
23peptidyl-lysine trimethylation (GO:0018023)3.12896629
24head development (GO:0060322)3.08355894
25regulation of telomere maintenance (GO:0032204)3.07857096
26mRNA splice site selection (GO:0006376)3.07390550
27kidney morphogenesis (GO:0060993)3.04019945
28central nervous system projection neuron axonogenesis (GO:0021952)3.01244903
29chromatin remodeling at centromere (GO:0031055)2.99351665
30keratinocyte development (GO:0003334)2.96105500
31dorsal/ventral axis specification (GO:0009950)2.94554867
32histone exchange (GO:0043486)2.92472029
33maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91194713
34cytoplasmic mRNA processing body assembly (GO:0033962)2.91012785
35regulation of timing of cell differentiation (GO:0048505)2.89815188
36resolution of meiotic recombination intermediates (GO:0000712)2.89108975
37double-strand break repair via nonhomologous end joining (GO:0006303)2.88837025
38non-recombinational repair (GO:0000726)2.88837025
39kinetochore organization (GO:0051383)2.88805275
40presynaptic membrane assembly (GO:0097105)2.83586181
41histone lysine methylation (GO:0034968)2.83354884
42recombinational repair (GO:0000725)2.80652141
43double-strand break repair via homologous recombination (GO:0000724)2.80485467
44neuron remodeling (GO:0016322)2.80303352
45CENP-A containing nucleosome assembly (GO:0034080)2.79830004
46kinetochore assembly (GO:0051382)2.75124377
47glucocorticoid receptor signaling pathway (GO:0042921)2.73981657
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72031043
49embryonic viscerocranium morphogenesis (GO:0048703)2.71553177
50histone H3-K9 methylation (GO:0051567)2.70877571
51otic vesicle formation (GO:0030916)2.70854145
52regulation of development, heterochronic (GO:0040034)2.70415091
53regulation of centrosome duplication (GO:0010824)2.69651910
54regulation of nuclear cell cycle DNA replication (GO:0033262)2.69437306
55mitochondrial DNA metabolic process (GO:0032042)2.69310880
56regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.67790260
57protein K6-linked ubiquitination (GO:0085020)2.67093592
58snRNA processing (GO:0016180)2.66885440
59negative regulation of chondrocyte differentiation (GO:0032331)2.66479327
60postreplication repair (GO:0006301)2.65612424
61positive regulation of gene expression, epigenetic (GO:0045815)2.65423445
62negative regulation of protein oligomerization (GO:0032460)2.64988993
63regulation of non-canonical Wnt signaling pathway (GO:2000050)2.64387781
64embryonic hindlimb morphogenesis (GO:0035116)2.64295926
65somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63999268
66somatic hypermutation of immunoglobulin genes (GO:0016446)2.63999268
67sister chromatid segregation (GO:0000819)2.63048987
68paraxial mesoderm development (GO:0048339)2.61754242
69histone H3-K9 modification (GO:0061647)2.61195006
70DNA ligation (GO:0006266)2.60102146
71negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59120376
72negative regulation of axon extension (GO:0030517)2.58340584
73regulation of centrosome cycle (GO:0046605)2.57707477
74snRNA metabolic process (GO:0016073)2.57594164
75planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57024320
76somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.55976412
77somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.55976412
78isotype switching (GO:0045190)2.55976412
79regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55856479
80regulation of stem cell maintenance (GO:2000036)2.54714005
81telomere maintenance via telomerase (GO:0007004)2.54650214
82negative regulation of dendrite development (GO:2000171)2.53765482
83lactate metabolic process (GO:0006089)2.52530730
84histone methylation (GO:0016571)2.52458330
85regulation of meiosis I (GO:0060631)2.52115971
86positive regulation of mRNA processing (GO:0050685)2.50282588
87sympathetic nervous system development (GO:0048485)2.49853823
88regulation of hippo signaling (GO:0035330)2.48981685
89positive regulation of cardiac muscle cell differentiation (GO:2000727)2.48404980
90hindbrain development (GO:0030902)2.48188427
91embryonic eye morphogenesis (GO:0048048)2.47651489
92face development (GO:0060324)2.47567095
93cerebral cortex radially oriented cell migration (GO:0021799)2.47300189
94DNA replication-dependent nucleosome assembly (GO:0006335)2.46753805
95DNA replication-dependent nucleosome organization (GO:0034723)2.46753805
96DNA replication checkpoint (GO:0000076)2.46232308
97regulation of DNA endoreduplication (GO:0032875)2.44241793
98artery development (GO:0060840)2.43135693
99centriole replication (GO:0007099)2.43070180
100kidney mesenchyme development (GO:0072074)2.42932526
101regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.42178969
102positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.42178969
103reciprocal meiotic recombination (GO:0007131)2.41819485
104reciprocal DNA recombination (GO:0035825)2.41819485
105somatic recombination of immunoglobulin gene segments (GO:0016447)2.41430424
106specification of organ identity (GO:0010092)2.40998090
107regulation of mesoderm development (GO:2000380)2.40915921
108regulation of T cell chemotaxis (GO:0010819)2.40885299
109positive regulation of T cell chemotaxis (GO:0010820)2.40885299
110anterior/posterior axis specification, embryo (GO:0008595)2.40592879
111glandular epithelial cell development (GO:0002068)2.40276992
112mitotic sister chromatid segregation (GO:0000070)2.39470287
113regulation of mRNA 3-end processing (GO:0031440)2.39212926
114presynaptic membrane organization (GO:0097090)2.39148935
115nucleosome disassembly (GO:0006337)2.37586651
116protein-DNA complex disassembly (GO:0032986)2.37586651
117microtubule anchoring (GO:0034453)2.36980274
118cellular response to fluid shear stress (GO:0071498)2.36962164
119positive regulation of mitotic sister chromatid separation (GO:1901970)2.36692727
120positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.36692727
121positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.36692727
122urogenital system development (GO:0001655)2.36642769
123cartilage morphogenesis (GO:0060536)2.35904990
124metanephric mesenchyme development (GO:0072075)2.35792111
125axonal fasciculation (GO:0007413)2.35319404
126DNA strand renaturation (GO:0000733)2.35083486
127regulation of histone H3-K4 methylation (GO:0051569)2.34789875
128layer formation in cerebral cortex (GO:0021819)2.34766213
129cell proliferation in forebrain (GO:0021846)2.34635959
130hindlimb morphogenesis (GO:0035137)2.34570338
131regulation of collateral sprouting (GO:0048670)2.34123228
132establishment of planar polarity (GO:0001736)2.33520314
133establishment of tissue polarity (GO:0007164)2.33520314
134pyrimidine-containing compound salvage (GO:0008655)2.33501317
135pyrimidine nucleoside salvage (GO:0043097)2.33501317
136double-strand break repair (GO:0006302)2.32951067
137regulation of RNA export from nucleus (GO:0046831)2.32910979
138spindle checkpoint (GO:0031577)2.32641390
139nuclear pore organization (GO:0006999)2.32492908
140negative regulation of axon guidance (GO:1902668)2.32376384
141stress granule assembly (GO:0034063)2.32248211
142peptidyl-lysine methylation (GO:0018022)2.31897528
143neural tube formation (GO:0001841)2.31831560
144intra-S DNA damage checkpoint (GO:0031573)2.31449916
145regulation of mitotic spindle checkpoint (GO:1903504)2.31254200
146regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.31254200
147cranial nerve morphogenesis (GO:0021602)2.31227182
148gene silencing by RNA (GO:0031047)2.30690188
149nuclear pore complex assembly (GO:0051292)2.30534704
150spinal cord development (GO:0021510)2.29567357
151metaphase plate congression (GO:0051310)2.29535814
152prostate gland growth (GO:0060736)2.29188142
153somatic diversification of immunoglobulins (GO:0016445)2.28015031
154DNA replication-independent nucleosome assembly (GO:0006336)2.27878143
155DNA replication-independent nucleosome organization (GO:0034724)2.27878143
156DNA topological change (GO:0006265)2.27505762
157dendrite morphogenesis (GO:0048813)2.26740611
158positive regulation of protein sumoylation (GO:0033235)2.25546269
159somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.25105121
160somatic cell DNA recombination (GO:0016444)2.25105121
161embryonic foregut morphogenesis (GO:0048617)2.24702660
162monoubiquitinated protein deubiquitination (GO:0035520)2.24499419
163alternative mRNA splicing, via spliceosome (GO:0000380)2.22792425
164hippo signaling (GO:0035329)2.22732688
165negative regulation of axon extension involved in axon guidance (GO:0048843)2.22572546
166corticosteroid receptor signaling pathway (GO:0031958)2.22554110
167heart field specification (GO:0003128)2.21175303
168secondary heart field specification (GO:0003139)2.21175303
169negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.19522821
170embryonic camera-type eye morphogenesis (GO:0048596)2.18185662
171negative regulation of histone methylation (GO:0031061)2.18170981
172mesenchymal cell differentiation (GO:0048762)2.17578351
173negative regulation of DNA repair (GO:0045738)2.17287121
174regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.13374642
175negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.13297127
176regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.12496693
177positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.12496693
178neuron recognition (GO:0008038)2.11966412
179embryonic digestive tract development (GO:0048566)2.11949154
180mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.11136831
181regulation of protein deacetylation (GO:0090311)2.10993271
182central nervous system neuron axonogenesis (GO:0021955)2.10703825
183somatic stem cell maintenance (GO:0035019)2.10541593
184cell proliferation involved in metanephros development (GO:0072203)2.10533040
185regulation of NFAT protein import into nucleus (GO:0051532)2.10037463
186positive regulation of histone deacetylation (GO:0031065)2.07965670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.71780610
2TP63_19390658_ChIP-ChIP_HaCaT_Human3.68953683
3ZNF274_21170338_ChIP-Seq_K562_Hela3.02449312
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94040470
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.73616775
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69055365
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.55351042
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.55351042
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.55351042
10VDR_22108803_ChIP-Seq_LS180_Human2.42308360
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36711676
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24524111
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.21443097
14E2F7_22180533_ChIP-Seq_HELA_Human2.11393410
15IGF1R_20145208_ChIP-Seq_DFB_Human2.08880516
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05524761
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.04534388
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92848548
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91862529
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.91281708
21SCL_19346495_ChIP-Seq_HPC-7_Human1.90989083
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.89160487
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85086258
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.83752633
25RING1B_27294783_Chip-Seq_NPCs_Mouse1.80762627
26* GBX2_23144817_ChIP-Seq_PC3_Human1.79335478
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.78265615
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.78005246
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76289921
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75739089
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.74872002
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.69652970
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69570725
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69402588
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68867632
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67399467
37ELK1_19687146_ChIP-ChIP_HELA_Human1.66501021
38ER_23166858_ChIP-Seq_MCF-7_Human1.62862378
39EWS_26573619_Chip-Seq_HEK293_Human1.61074278
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59848884
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59674475
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59674475
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58552604
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.58203041
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58116958
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.57069720
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56799102
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56421496
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.56005177
50* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54599766
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.53643392
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52233703
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.51690987
54RNF2_27304074_Chip-Seq_NSC_Mouse1.47150126
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44044321
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43329614
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42889711
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40792225
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40186795
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39837190
61* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39718208
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39674859
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39499957
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.37148384
65BCAT_22108803_ChIP-Seq_LS180_Human1.37097701
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36906382
67STAT3_23295773_ChIP-Seq_U87_Human1.36024149
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35240613
69FUS_26573619_Chip-Seq_HEK293_Human1.33808207
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33482716
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33302356
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.33207932
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.32543184
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31569945
75AR_21909140_ChIP-Seq_LNCAP_Human1.31253592
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31219802
77CBP_20019798_ChIP-Seq_JUKART_Human1.31219802
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30718105
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30436663
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29751409
81P300_19829295_ChIP-Seq_ESCs_Human1.29556009
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29549454
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29475712
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29377426
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29058210
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.28175318
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28021468
88* ISL1_27105846_Chip-Seq_CPCs_Mouse1.27993527
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27370945
90AHR_22903824_ChIP-Seq_MCF-7_Human1.26982771
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.25857476
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25301605
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25301605
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25213105
95TCF4_23295773_ChIP-Seq_U87_Human1.24878838
96* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23820542
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.23381896
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23371353
99* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23295160
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22793770
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.22764606
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22580637
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22072900
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21514054
105NANOG_16153702_ChIP-ChIP_HESCs_Human1.21011108
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20163365
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.19208024
108* TCF7_22412390_ChIP-Seq_EML_Mouse1.18993749
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18934058
110MYC_18940864_ChIP-ChIP_HL60_Human1.18260858
111FOXM1_23109430_ChIP-Seq_U2OS_Human1.17966847
112* MYC_22102868_ChIP-Seq_BL_Human1.17908150
113* AR_25329375_ChIP-Seq_VCAP_Human1.17068189
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16530329
115* SMAD3_21741376_ChIP-Seq_EPCs_Human1.14875534
116TCF4_22108803_ChIP-Seq_LS180_Human1.14653467
117KDM2B_26808549_Chip-Seq_DND41_Human1.13515969
118EZH2_27294783_Chip-Seq_ESCs_Mouse1.12991506
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12803176
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.12228959
121DROSHA_22980978_ChIP-Seq_HELA_Human1.11959334
122SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11470772
123WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11428956
124P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11311679
125TP53_16413492_ChIP-PET_HCT116_Human1.11310753
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10055476
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09895540
128CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09485574
129CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09217316
130BP1_19119308_ChIP-ChIP_Hs578T_Human1.08953424
131SOX2_16153702_ChIP-ChIP_HESCs_Human1.08846335
132SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08055726
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07076351
134ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06938721
135NOTCH1_21737748_ChIP-Seq_TLL_Human1.06867411
136NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05866175
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05264516
138KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05239007
139TAF15_26573619_Chip-Seq_HEK293_Human1.05232924
140SMAD4_21799915_ChIP-Seq_A2780_Human1.05017803
141KDM2B_26808549_Chip-Seq_K562_Human1.04779324
142* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04769364
143SMAD3_21741376_ChIP-Seq_ESCs_Human1.04507937
144RUNX_20019798_ChIP-Seq_JUKART_Human1.04118793
145SOX9_26525672_Chip-Seq_HEART_Mouse1.03675875
146* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02982863
147RUNX2_22187159_ChIP-Seq_PCA_Human1.02400847
148AR_19668381_ChIP-Seq_PC3_Human1.02063383
149* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01944661
150* E2F1_18555785_Chip-Seq_ESCs_Mouse1.01335437
151* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00440957
152TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00294490
153PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99555308
154NFE2_27457419_Chip-Seq_LIVER_Mouse0.99540345
155TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99448997
156IRF1_19129219_ChIP-ChIP_H3396_Human0.99219537
157RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98934783
158AR_21572438_ChIP-Seq_LNCaP_Human0.98710443
159GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98143534
160* P53_22387025_ChIP-Seq_ESCs_Mouse0.97548586
161* SMAD4_21741376_ChIP-Seq_EPCs_Human0.97402376
162CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97384106
163KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94797158
164* P300_18555785_Chip-Seq_ESCs_Mouse0.94295540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.85357135
2MP0000569_abnormal_digit_pigmentation3.51840655
3MP0003787_abnormal_imprinting3.09033255
4MP0002102_abnormal_ear_morphology2.88593209
5MP0005248_abnormal_Harderian_gland2.86742234
6MP0003121_genomic_imprinting2.73872316
7MP0003122_maternal_imprinting2.38284620
8MP0008057_abnormal_DNA_replication2.34037771
9MP0002249_abnormal_larynx_morphology2.24571127
10MP0006292_abnormal_olfactory_placode2.24403144
11MP0003567_abnormal_fetal_cardiomyocyte2.18928404
12MP0008058_abnormal_DNA_repair2.12248229
13MP0005367_renal/urinary_system_phenotyp2.04131201
14MP0000516_abnormal_urinary_system2.04131201
15MP0002938_white_spotting1.93193527
16MP0003385_abnormal_body_wall1.86412998
17MP0000372_irregular_coat_pigmentation1.84821248
18MP0008877_abnormal_DNA_methylation1.84232034
19MP0000778_abnormal_nervous_system1.80983631
20MP0000534_abnormal_ureter_morphology1.77464334
21MP0003693_abnormal_embryo_hatching1.77291783
22MP0000049_abnormal_middle_ear1.72507971
23MP0003942_abnormal_urinary_system1.68851408
24MP0003111_abnormal_nucleus_morphology1.64364629
25MP0003283_abnormal_digestive_organ1.62806366
26MP0001293_anophthalmia1.62537968
27MP0005076_abnormal_cell_differentiation1.61117941
28MP0003890_abnormal_embryonic-extraembry1.58694569
29MP0000566_synostosis1.57367321
30MP0000537_abnormal_urethra_morphology1.55235110
31MP0003935_abnormal_craniofacial_develop1.53462808
32MP0003937_abnormal_limbs/digits/tail_de1.52849129
33MP0004957_abnormal_blastocyst_morpholog1.52784252
34MP0002233_abnormal_nose_morphology1.50794441
35MP0003755_abnormal_palate_morphology1.46878226
36MP0009250_abnormal_appendicular_skeleto1.46380732
37MP0002932_abnormal_joint_morphology1.45837063
38MP0001485_abnormal_pinna_reflex1.45017013
39MP0002116_abnormal_craniofacial_bone1.42028384
40MP0004808_abnormal_hematopoietic_stem1.38044100
41MP0009278_abnormal_bone_marrow1.34230440
42MP0008789_abnormal_olfactory_epithelium1.33937582
43MP0000427_abnormal_hair_cycle1.33514222
44* MP0003861_abnormal_nervous_system1.32777010
45MP0002234_abnormal_pharynx_morphology1.32271584
46MP0009053_abnormal_anal_canal1.31990537
47MP0003938_abnormal_ear_development1.29514813
48MP0000647_abnormal_sebaceous_gland1.27208930
49MP0003077_abnormal_cell_cycle1.26420968
50MP0003136_yellow_coat_color1.25872145
51MP0000432_abnormal_head_morphology1.24147328
52MP0000631_abnormal_neuroendocrine_gland1.23815204
53MP0002282_abnormal_trachea_morphology1.23489568
54MP0005646_abnormal_pituitary_gland1.22511547
55MP0005623_abnormal_meninges_morphology1.21141438
56MP0001177_atelectasis1.20122596
57MP0003718_maternal_effect1.16679970
58MP0000428_abnormal_craniofacial_morphol1.16519339
59MP0008995_early_reproductive_senescence1.14340665
60MP0001286_abnormal_eye_development1.14276052
61MP0002160_abnormal_reproductive_system1.13758407
62MP0008932_abnormal_embryonic_tissue1.12123215
63MP0003119_abnormal_digestive_system1.11244541
64MP0009703_decreased_birth_body1.10925585
65MP0003941_abnormal_skin_development1.10254080
66MP0002736_abnormal_nociception_after1.08923353
67MP0005075_abnormal_melanosome_morpholog1.08112710
68MP0005394_taste/olfaction_phenotype1.08099159
69MP0005499_abnormal_olfactory_system1.08099159
70MP0005174_abnormal_tail_pigmentation1.07654286
71MP0000383_abnormal_hair_follicle1.07519716
72MP0002751_abnormal_autonomic_nervous1.07495066
73MP0005187_abnormal_penis_morphology1.05617347
74MP0004197_abnormal_fetal_growth/weight/1.05255372
75MP0000955_abnormal_spinal_cord1.04899718
76MP0002081_perinatal_lethality1.04498018
77MP0003115_abnormal_respiratory_system1.03761189
78MP0002114_abnormal_axial_skeleton1.02906754
79MP0001340_abnormal_eyelid_morphology1.01935784
80MP0003315_abnormal_perineum_morphology1.00350108
81MP0003786_premature_aging0.99757398
82MP0001529_abnormal_vocalization0.99166700
83MP0004885_abnormal_endolymph0.99161335
84MP0003123_paternal_imprinting0.98898594
85MP0001697_abnormal_embryo_size0.98477319
86MP0000733_abnormal_muscle_development0.98283106
87MP0001968_abnormal_touch/_nociception0.98200186
88MP0003880_abnormal_central_pattern0.98104219
89MP0002210_abnormal_sex_determination0.98046453
90MP0004233_abnormal_muscle_weight0.97631861
91MP0004859_abnormal_synaptic_plasticity0.97494983
92MP0002152_abnormal_brain_morphology0.97065978
93MP0003195_calcinosis0.96340927
94MP0001145_abnormal_male_reproductive0.95922418
95MP0000762_abnormal_tongue_morphology0.95704965
96MP0001929_abnormal_gametogenesis0.95131833
97MP0006072_abnormal_retinal_apoptosis0.94617258
98MP0002396_abnormal_hematopoietic_system0.93612123
99MP0000653_abnormal_sex_gland0.93455994
100MP0008961_abnormal_basal_metabolism0.92690936
101MP0002084_abnormal_developmental_patter0.92612292
102MP0002925_abnormal_cardiovascular_devel0.92014543
103MP0002177_abnormal_outer_ear0.91097065
104MP0005551_abnormal_eye_electrophysiolog0.90666740
105MP0002109_abnormal_limb_morphology0.90400671
106MP0002092_abnormal_eye_morphology0.90349923
107* MP0002085_abnormal_embryonic_tissue0.89689594
108MP0004134_abnormal_chest_morphology0.88876803
109MP0010678_abnormal_skin_adnexa0.88684676
110MP0003828_pulmonary_edema0.87934307
111MP0002697_abnormal_eye_size0.87863602
112MP0005409_darkened_coat_color0.85742593
113MP0002184_abnormal_innervation0.85019218
114MP0008872_abnormal_physiological_respon0.84816517
115MP0005253_abnormal_eye_physiology0.84533009
116MP0005423_abnormal_somatic_nervous0.84060601
117MP0009697_abnormal_copulation0.83161290
118MP0010352_gastrointestinal_tract_polyps0.82631113
119MP0002111_abnormal_tail_morphology0.82507683
120MP0005380_embryogenesis_phenotype0.80041768
121MP0001672_abnormal_embryogenesis/_devel0.80041768
122MP0004264_abnormal_extraembryonic_tissu0.77055515
123MP0005391_vision/eye_phenotype0.76785429
124MP0010094_abnormal_chromosome_stability0.76320534
125MP0005195_abnormal_posterior_eye0.76021298
126MP0002009_preneoplasia0.75875960
127MP0005508_abnormal_skeleton_morphology0.74601963
128MP0003632_abnormal_nervous_system0.73027402
129MP0010630_abnormal_cardiac_muscle0.72848682
130MP0000613_abnormal_salivary_gland0.72845951
131MP0003635_abnormal_synaptic_transmissio0.72324247
132MP0001502_abnormal_circadian_rhythm0.69991824
133MP0003943_abnormal_hepatobiliary_system0.69489310
134MP0002086_abnormal_extraembryonic_tissu0.68266530
135MP0002882_abnormal_neuron_morphology0.68035607
136MP0002063_abnormal_learning/memory/cond0.67897997
137MP0001188_hyperpigmentation0.66368687
138MP0004133_heterotaxia0.64289452

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.82104095
2Progressive inability to walk (HP:0002505)4.10359169
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.79676592
4Short 4th metacarpal (HP:0010044)3.79676592
5Absent frontal sinuses (HP:0002688)3.39376009
6Supernumerary bones of the axial skeleton (HP:0009144)3.30945075
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.30634456
8Facial diplegia (HP:0001349)3.29890427
9Abnormality of the labia minora (HP:0012880)3.28989778
10Neoplasm of the adrenal cortex (HP:0100641)3.23211914
11Chromsome breakage (HP:0040012)3.19374973
12Abnormality of chromosome stability (HP:0003220)2.91938206
13Annular pancreas (HP:0001734)2.83270175
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.81448127
15Syringomyelia (HP:0003396)2.73738690
16Spinal cord lesions (HP:0100561)2.73738690
17Hypochromic microcytic anemia (HP:0004840)2.73105554
18Meckel diverticulum (HP:0002245)2.70413477
19Pancreatic cysts (HP:0001737)2.68294871
20Abnormality of the 4th metacarpal (HP:0010012)2.66980438
21Neoplasm of the oral cavity (HP:0100649)2.66579103
22Abnormality of the fingertips (HP:0001211)2.64567411
23Abnormality of the ileum (HP:0001549)2.62227917
24Long eyelashes (HP:0000527)2.60406723
25True hermaphroditism (HP:0010459)2.56843486
26Supernumerary ribs (HP:0005815)2.56643900
27Midline defect of the nose (HP:0004122)2.51790816
28Pancreatic fibrosis (HP:0100732)2.51552001
29Tented upper lip vermilion (HP:0010804)2.47717485
30Abnormality of the heme biosynthetic pathway (HP:0010472)2.46071795
31Inability to walk (HP:0002540)2.42864616
32Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.42310739
33Ependymoma (HP:0002888)2.41087609
34Abnormality of the parietal bone (HP:0002696)2.39557384
35Intestinal atresia (HP:0011100)2.39557175
36Aqueductal stenosis (HP:0002410)2.37472780
37Lip pit (HP:0100267)2.31842690
38Abnormality of the astrocytes (HP:0100707)2.31683757
39Astrocytoma (HP:0009592)2.31683757
40Glioma (HP:0009733)2.31610863
41Abnormality of the nasal septum (HP:0000419)2.31116186
42Abnormality of the preputium (HP:0100587)2.28498802
43Trigonocephaly (HP:0000243)2.27566962
44Abnormal number of incisors (HP:0011064)2.25634278
45Increased number of teeth (HP:0011069)2.24477440
46Abnormal pancreas size (HP:0012094)2.24344383
47Pendular nystagmus (HP:0012043)2.23860158
48Small intestinal stenosis (HP:0012848)2.23255288
49Duodenal stenosis (HP:0100867)2.23255288
50Shallow orbits (HP:0000586)2.21266636
51Abnormality of the duodenum (HP:0002246)2.21226313
52Nephroblastoma (Wilms tumor) (HP:0002667)2.20883687
53Abnormality of the frontal sinuses (HP:0002687)2.19147705
54Embryonal renal neoplasm (HP:0011794)2.16882617
55Open mouth (HP:0000194)2.16348862
56Septo-optic dysplasia (HP:0100842)2.16096201
57Anophthalmia (HP:0000528)2.15009839
58Large earlobe (HP:0009748)2.13369252
59Colon cancer (HP:0003003)2.12721044
60Abnormality of the parathyroid morphology (HP:0011766)2.08777227
61Nephronophthisis (HP:0000090)2.08463453
62Protruding tongue (HP:0010808)2.07466948
63Febrile seizures (HP:0002373)2.05682145
64* Obsessive-compulsive behavior (HP:0000722)2.04113917
65Sloping forehead (HP:0000340)2.03735831
66Increased nuchal translucency (HP:0010880)2.02691199
67Intestinal fistula (HP:0100819)2.02607208
68Oligodactyly (hands) (HP:0001180)2.01736107
69Preaxial hand polydactyly (HP:0001177)1.97457328
70Abnormality of the carotid arteries (HP:0005344)1.97403697
71Morphological abnormality of the middle ear (HP:0008609)1.94880289
72Abnormality of the phalanges of the hallux (HP:0010057)1.94638417
73Abnormality of the renal cortex (HP:0011035)1.94553567
74Absent radius (HP:0003974)1.94368401
75Methylmalonic acidemia (HP:0002912)1.92986148
76Abnormality of the incisor (HP:0000676)1.91765115
77Narrow palate (HP:0000189)1.90908106
78Gaze-evoked nystagmus (HP:0000640)1.89934988
79Bifid tongue (HP:0010297)1.89631088
80Abnormality of the renal medulla (HP:0100957)1.89340488
81Deep philtrum (HP:0002002)1.87132952
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.86916391
83Triphalangeal thumb (HP:0001199)1.86621182
84Macroorchidism (HP:0000053)1.85990289
85Gastrointestinal atresia (HP:0002589)1.85928034
86Short philtrum (HP:0000322)1.85879505
87Short 1st metacarpal (HP:0010034)1.85394629
88Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.85394629
89Absent forearm bone (HP:0003953)1.85188441
90Aplasia involving forearm bones (HP:0009822)1.85188441
91Thick eyebrow (HP:0000574)1.84796174
92Cutaneous finger syndactyly (HP:0010554)1.84590409
93Hypoplastic pelvis (HP:0008839)1.84012183
94Clubbing of toes (HP:0100760)1.83864438
95Vesicoureteral reflux (HP:0000076)1.82383249
96Facial hemangioma (HP:0000329)1.81736350
97Dandy-Walker malformation (HP:0001305)1.80991274
98Renal hypoplasia (HP:0000089)1.80865842
99Fair hair (HP:0002286)1.80119041
100Broad thumb (HP:0011304)1.80105312
101Ectopic kidney (HP:0000086)1.79580514
102Hyperventilation (HP:0002883)1.78150775
103Molar tooth sign on MRI (HP:0002419)1.77685170
104Abnormality of midbrain morphology (HP:0002418)1.77685170
105Gonadotropin excess (HP:0000837)1.76627509
106Intestinal malrotation (HP:0002566)1.76410988
107Hypoplasia of the maxilla (HP:0000327)1.76013285
108Proximal placement of thumb (HP:0009623)1.75724973
109Tapered finger (HP:0001182)1.75185796
110Genetic anticipation (HP:0003743)1.75058845
111Shawl scrotum (HP:0000049)1.74559963
112Oligodontia (HP:0000677)1.74455600
113Hepatoblastoma (HP:0002884)1.74030592
114Excessive salivation (HP:0003781)1.73999231
115Drooling (HP:0002307)1.73999231
116Bilateral microphthalmos (HP:0007633)1.73614134
117Truncal obesity (HP:0001956)1.72773379
118Renal duplication (HP:0000075)1.72363496
119Neoplasm of the adrenal gland (HP:0100631)1.72360026
120Hyperacusis (HP:0010780)1.71967389
121Rib fusion (HP:0000902)1.71882748
122Abnormality of the intervertebral disk (HP:0005108)1.71854189
123Dislocated radial head (HP:0003083)1.71403615
124Cystic liver disease (HP:0006706)1.70864668
125Chronic hepatic failure (HP:0100626)1.70669389
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.70459954
127Patellar aplasia (HP:0006443)1.70338068
128Abnormality of the radial head (HP:0003995)1.70208131
129Medulloblastoma (HP:0002885)1.70165255
130Deeply set eye (HP:0000490)1.69985673
131Abnormality of abdominal situs (HP:0011620)1.69289015
132Abdominal situs inversus (HP:0003363)1.69289015
133Ragged-red muscle fibers (HP:0003200)1.68789522
134Inappropriate behavior (HP:0000719)1.68050136
135Dental malocclusion (HP:0000689)1.67298301
136Breast carcinoma (HP:0003002)1.65765764
137Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.64870740
138High anterior hairline (HP:0009890)1.64788673
139Esophageal atresia (HP:0002032)1.64555613
140Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64482355
141Heterotopia (HP:0002282)1.64290652
142Narrow forehead (HP:0000341)1.64214327
143Atresia of the external auditory canal (HP:0000413)1.63969794
144Exotropia (HP:0000577)1.63914954
145Abnormality of the 1st metacarpal (HP:0010009)1.63741529
146Patellar dislocation (HP:0002999)1.63285424
147Skull defect (HP:0001362)1.62703422
148Optic nerve hypoplasia (HP:0000609)1.62675279
149Deviation of the thumb (HP:0009603)1.62447295
150Aplasia/Hypoplasia of the patella (HP:0006498)1.62404351
151Abnormality of the proximal phalanges of the hand (HP:0009834)1.62206142
152Weak cry (HP:0001612)1.61858875
153Abnormal lung lobation (HP:0002101)1.61621217
154Low anterior hairline (HP:0000294)1.61307001
155Labial hypoplasia (HP:0000066)1.61192495
156Genital tract atresia (HP:0001827)1.61082294
157Aplasia cutis congenita (HP:0001057)1.60773730
158Oligodactyly (HP:0012165)1.60662891
159Sclerocornea (HP:0000647)1.60423743
160Urethral obstruction (HP:0000796)1.60215851
161Rhabdomyosarcoma (HP:0002859)1.59824365
162Carpal bone hypoplasia (HP:0001498)1.59676766
163Tubulointerstitial nephritis (HP:0001970)1.58871959
164Synophrys (HP:0000664)1.58831529
165Skin tags (HP:0010609)1.57914060
166Hypoplastic female external genitalia (HP:0012815)1.57631508
167Abnormality of the labia majora (HP:0012881)1.57540047
168Renal cortical cysts (HP:0000803)1.57150313
169Abnormality of chromosome segregation (HP:0002916)1.57010610
170Cutis marmorata (HP:0000965)1.56470611
171Cupped ear (HP:0000378)1.56088758
172Hypoplastic labia majora (HP:0000059)1.55718139
173Vaginal atresia (HP:0000148)1.55670182
174Lissencephaly (HP:0001339)1.54540564
175Increased corneal curvature (HP:0100692)1.54208189
176Keratoconus (HP:0000563)1.54208189
177Sacral dimple (HP:0000960)1.54009178
178Bicornuate uterus (HP:0000813)1.53201610
179Abnormality of the phalanges of the 2nd finger (HP:0009541)1.53009773
180Buphthalmos (HP:0000557)1.52864820
181Anal stenosis (HP:0002025)1.52381741
182Acute lymphatic leukemia (HP:0006721)1.51973412
183Leiomyosarcoma (HP:0100243)1.51533811
184Uterine leiomyosarcoma (HP:0002891)1.51533811
185Sparse scalp hair (HP:0002209)1.51460723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.00586051
2FRK3.41496350
3TRIM282.86501572
4SIK22.83095138
5BRD42.64694153
6WNK32.64291316
7WEE12.42109130
8BMPR1B2.41315555
9EIF2AK32.33819829
10MARK12.17775011
11FGFR32.17214373
12MKNK22.17049220
13CAMK1G2.12347545
14LATS12.09465311
15CASK2.08038943
16BRSK22.06221775
17ACVR1B2.05512462
18PLK42.03403195
19MKNK11.92394291
20MAP3K101.90088107
21PLK31.85881291
22ICK1.74474734
23TAF11.73665491
24BUB11.66908374
25MAP4K21.64781229
26SIK11.61663380
27CDK61.59955094
28CAMK1D1.58200193
29BCR1.50553066
30MAPK131.45963152
31GRK11.45638937
32EIF2AK11.44967663
33STK391.38399816
34CSNK1A1L1.35973249
35TTK1.35659115
36DYRK1A1.33849627
37PNCK1.33578444
38ERBB31.32955324
39PRKD21.31399122
40EPHB21.31069890
41ZAK1.29352228
42DMPK1.27468641
43TNIK1.26904439
44EPHA31.26725062
45PDGFRA1.25783709
46AKT31.22833926
47STK38L1.20394591
48CDC71.16638940
49EPHA41.15965069
50UHMK11.15205188
51MAP4K11.15135691
52PLK11.13988026
53SGK31.10384370
54OXSR11.09563714
55INSRR1.07755996
56MAPKAPK51.06945093
57MST41.05900932
58MAPK71.05693430
59LATS21.05652833
60NTRK21.02911315
61MARK21.02395930
62CSNK1G10.99246202
63CAMK40.98080427
64MTOR0.98042038
65RIPK10.97177785
66SIK30.97034377
67CDK30.96375591
68SGK20.96327983
69PDGFRB0.95769974
70CDK40.95472706
71EEF2K0.93923147
72MAP3K40.91640257
73CSNK1G30.91582585
74NUAK10.89044204
75CHUK0.89033779
76CDK70.88420678
77TGFBR10.86629286
78TSSK60.86119942
79ADRBK20.85888329
80CSNK1G20.85732031
81STK30.84550301
82NEK10.83260854
83HIPK20.83246248
84EIF2AK20.82884838
85SRPK10.81417593
86DDR20.81227593
87VRK10.81043630
88MAPK140.80586174
89PBK0.79637359
90ATR0.77619556
91PLK20.76978073
92MAPK80.75591207
93BRSK10.74714184
94VRK20.74469833
95PASK0.73333277
96WNK10.73142621
97PAK30.72445048
98MAP3K60.70677300
99YES10.70067534
100CDK90.69424579
101ALK0.69420353
102GSK3B0.68594244
103DYRK1B0.67850184
104MELK0.67282982
105FGFR10.65798363
106CDK20.64807091
107CHEK20.64684947
108FGFR20.64585546
109CCNB10.64014827
110MAPK90.63291675
111ERBB20.63059660
112CDK10.62980414
113MAPK10.62033747
114PRKCE0.61675576
115MAP2K70.61616559
116ERBB40.61170588
117ATM0.60253186
118MAPK100.59996872
119FGR0.59465270
120DYRK20.58111735
121TYRO30.57942599
122AKT10.57709358
123PTK20.55539348
124FER0.55333787
125CDC42BPA0.54958898
126RPS6KB10.54736573
127CHEK10.54607737
128CSNK1D0.54261860
129PRKDC0.54205223
130MAP3K70.53612648
131NTRK30.52582806
132MAP3K90.51733928
133CSF1R0.51519434
134CLK10.51450088
135WNK40.50329326
136HCK0.49798832
137NLK0.49422655
138STK40.49365873
139STK110.49326923
140PRKCG0.48999403
141BMPR20.48027306
142CDK80.47957540
143BMX0.47933705
144MINK10.46986347
145NEK20.46817215
146MUSK0.46799143
147RPS6KB20.46221084
148PRKD10.46209857
149SGK10.45857512
150PRKCI0.45270200
151KSR10.43721267
152MATK0.43114712
153PRKAA20.42320732
154PIK3CA0.41892347
155CSNK1E0.39412214
156AURKB0.39227061
157MET0.31366250

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.15803195
2Selenocompound metabolism_Homo sapiens_hsa004502.22328700
3RNA transport_Homo sapiens_hsa030132.20963795
4Protein export_Homo sapiens_hsa030602.20490099
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15791610
6DNA replication_Homo sapiens_hsa030302.15550701
7Basal transcription factors_Homo sapiens_hsa030222.10443867
8Propanoate metabolism_Homo sapiens_hsa006401.89380576
9Basal cell carcinoma_Homo sapiens_hsa052171.82987250
10Steroid biosynthesis_Homo sapiens_hsa001001.77453526
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73840520
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73747523
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71770303
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.63641917
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60057700
16RNA polymerase_Homo sapiens_hsa030201.57138230
17Hedgehog signaling pathway_Homo sapiens_hsa043401.55761379
18Axon guidance_Homo sapiens_hsa043601.49918636
19MicroRNAs in cancer_Homo sapiens_hsa052061.47045479
20Nucleotide excision repair_Homo sapiens_hsa034201.45881379
21Base excision repair_Homo sapiens_hsa034101.40193430
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.37756437
23Wnt signaling pathway_Homo sapiens_hsa043101.37655856
24Notch signaling pathway_Homo sapiens_hsa043301.36738933
25One carbon pool by folate_Homo sapiens_hsa006701.35302247
26Nicotine addiction_Homo sapiens_hsa050331.34914901
27Phototransduction_Homo sapiens_hsa047441.32567139
28Oocyte meiosis_Homo sapiens_hsa041141.31552070
29Lysine degradation_Homo sapiens_hsa003101.30111040
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28197587
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28087129
32Nitrogen metabolism_Homo sapiens_hsa009101.27043570
33Proteasome_Homo sapiens_hsa030501.22278628
34Chronic myeloid leukemia_Homo sapiens_hsa052201.19564358
35Caffeine metabolism_Homo sapiens_hsa002321.19293319
36Hippo signaling pathway_Homo sapiens_hsa043901.18818279
37Dorso-ventral axis formation_Homo sapiens_hsa043201.18216973
38p53 signaling pathway_Homo sapiens_hsa041151.17301564
39Circadian entrainment_Homo sapiens_hsa047131.16364964
40Taste transduction_Homo sapiens_hsa047421.16363017
41Colorectal cancer_Homo sapiens_hsa052101.16162395
42Non-small cell lung cancer_Homo sapiens_hsa052231.13830183
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12466725
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12110083
45ErbB signaling pathway_Homo sapiens_hsa040121.11662387
46Butanoate metabolism_Homo sapiens_hsa006501.10306444
47Glutamatergic synapse_Homo sapiens_hsa047241.09591259
48Non-homologous end-joining_Homo sapiens_hsa034501.08334821
49mRNA surveillance pathway_Homo sapiens_hsa030151.07620234
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06133271
51Long-term depression_Homo sapiens_hsa047301.04607486
52Melanogenesis_Homo sapiens_hsa049161.02413585
53Viral myocarditis_Homo sapiens_hsa054161.01110711
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01080105
55Long-term potentiation_Homo sapiens_hsa047201.00813643
56Adherens junction_Homo sapiens_hsa045200.99046896
57Morphine addiction_Homo sapiens_hsa050320.98621256
58Endometrial cancer_Homo sapiens_hsa052130.97427489
59Pathways in cancer_Homo sapiens_hsa052000.96804438
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96802069
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96400239
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94891070
63Renin secretion_Homo sapiens_hsa049240.94847453
64Melanoma_Homo sapiens_hsa052180.93861485
65TGF-beta signaling pathway_Homo sapiens_hsa043500.93775655
66MAPK signaling pathway_Homo sapiens_hsa040100.93015439
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92453732
68Glioma_Homo sapiens_hsa052140.90994965
69Fanconi anemia pathway_Homo sapiens_hsa034600.90559264
70Prostate cancer_Homo sapiens_hsa052150.90331937
71Serotonergic synapse_Homo sapiens_hsa047260.89758530
72Cell cycle_Homo sapiens_hsa041100.89698736
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89412637
74Proteoglycans in cancer_Homo sapiens_hsa052050.89051376
75Cocaine addiction_Homo sapiens_hsa050300.88514778
76Choline metabolism in cancer_Homo sapiens_hsa052310.88313106
77Cholinergic synapse_Homo sapiens_hsa047250.86597349
78HTLV-I infection_Homo sapiens_hsa051660.86597162
79B cell receptor signaling pathway_Homo sapiens_hsa046620.85736184
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84503799
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.84226906
82T cell receptor signaling pathway_Homo sapiens_hsa046600.82358688
83Dopaminergic synapse_Homo sapiens_hsa047280.82279425
84GnRH signaling pathway_Homo sapiens_hsa049120.82147747
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.81408538
86Hepatitis B_Homo sapiens_hsa051610.80756948
87Rap1 signaling pathway_Homo sapiens_hsa040150.79173924
88Oxytocin signaling pathway_Homo sapiens_hsa049210.78924791
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78634470
90Small cell lung cancer_Homo sapiens_hsa052220.78210107
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77158734
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77155034
93cAMP signaling pathway_Homo sapiens_hsa040240.77152776
94Gap junction_Homo sapiens_hsa045400.76916932
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76771061
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76623764
97Herpes simplex infection_Homo sapiens_hsa051680.76371580
98GABAergic synapse_Homo sapiens_hsa047270.75878234
99Amphetamine addiction_Homo sapiens_hsa050310.74985320
100Estrogen signaling pathway_Homo sapiens_hsa049150.73821019
101mTOR signaling pathway_Homo sapiens_hsa041500.73685883
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72856319
103Renal cell carcinoma_Homo sapiens_hsa052110.72853281
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71828547
105Olfactory transduction_Homo sapiens_hsa047400.71666749
106Pancreatic cancer_Homo sapiens_hsa052120.71612236
107Tight junction_Homo sapiens_hsa045300.71605500
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.71147007
109Platelet activation_Homo sapiens_hsa046110.71130119
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70903362
111Acute myeloid leukemia_Homo sapiens_hsa052210.70702803
112Pyruvate metabolism_Homo sapiens_hsa006200.70300187
113Mismatch repair_Homo sapiens_hsa034300.70233791
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69397468
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69369759
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68838618
117Tryptophan metabolism_Homo sapiens_hsa003800.68639027
118Osteoclast differentiation_Homo sapiens_hsa043800.68442953
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68222780
120Ras signaling pathway_Homo sapiens_hsa040140.68094989
121Chemokine signaling pathway_Homo sapiens_hsa040620.68067728
122Type II diabetes mellitus_Homo sapiens_hsa049300.67822450
123Salivary secretion_Homo sapiens_hsa049700.67548390
124Ether lipid metabolism_Homo sapiens_hsa005650.67161885
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66260609
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65866840
127Linoleic acid metabolism_Homo sapiens_hsa005910.65432169
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65411359
129Purine metabolism_Homo sapiens_hsa002300.64783740
130FoxO signaling pathway_Homo sapiens_hsa040680.63787881
131Dilated cardiomyopathy_Homo sapiens_hsa054140.63724898
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63141517
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62886201
134Spliceosome_Homo sapiens_hsa030400.62546452
135Focal adhesion_Homo sapiens_hsa045100.61889033
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60895263
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59934297
138Calcium signaling pathway_Homo sapiens_hsa040200.59711854
139RNA degradation_Homo sapiens_hsa030180.59386412
140Fatty acid metabolism_Homo sapiens_hsa012120.56991192
141Vitamin digestion and absorption_Homo sapiens_hsa049770.55635815
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54403272
143Pyrimidine metabolism_Homo sapiens_hsa002400.50139929
144Insulin secretion_Homo sapiens_hsa049110.49735764
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47124269
146Vitamin B6 metabolism_Homo sapiens_hsa007500.45435560
147beta-Alanine metabolism_Homo sapiens_hsa004100.43919935
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42993926
149Peroxisome_Homo sapiens_hsa041460.40604230
150Circadian rhythm_Homo sapiens_hsa047100.38420774
151Retinol metabolism_Homo sapiens_hsa008300.35358411
152Regulation of autophagy_Homo sapiens_hsa041400.33941519
153Glucagon signaling pathway_Homo sapiens_hsa049220.32815957
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28890267
155N-Glycan biosynthesis_Homo sapiens_hsa005100.28062265
156Glycerolipid metabolism_Homo sapiens_hsa005610.27172365
157Fatty acid degradation_Homo sapiens_hsa000710.26535074
158Thyroid hormone synthesis_Homo sapiens_hsa049180.25475635

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