ADO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.91337494
2axon ensheathment in central nervous system (GO:0032291)8.91337494
3fatty acid elongation (GO:0030497)6.81951126
4cellular protein complex localization (GO:0034629)5.76723054
5long-chain fatty acid biosynthetic process (GO:0042759)5.51494858
6myelination (GO:0042552)5.36838417
7axon ensheathment (GO:0008366)5.34052166
8ensheathment of neurons (GO:0007272)5.34052166
9protein complex localization (GO:0031503)4.97014212
10negative regulation of neurotransmitter secretion (GO:0046929)4.90976013
11nuclear pore complex assembly (GO:0051292)4.85797580
12response to redox state (GO:0051775)4.83649730
13mitotic chromosome condensation (GO:0007076)4.81905447
14protein neddylation (GO:0045116)4.78961089
15myelin maintenance (GO:0043217)4.62970645
16negative regulation of neurotransmitter transport (GO:0051589)4.54710650
17cholesterol biosynthetic process (GO:0006695)4.50353863
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.46242294
19protein localization to chromosome, centromeric region (GO:0071459)4.42062791
20nuclear pore organization (GO:0006999)4.33614847
21presynaptic membrane assembly (GO:0097105)4.20286591
22regulation of chromatin binding (GO:0035561)4.16945226
23presynaptic membrane organization (GO:0097090)4.16401196
24negative regulation of execution phase of apoptosis (GO:1900118)4.03592242
25sterol biosynthetic process (GO:0016126)4.00841501
26oligodendrocyte differentiation (GO:0048709)3.86842144
27DNA ligation (GO:0006266)3.82323815
28astrocyte development (GO:0014002)3.71862023
29cullin deneddylation (GO:0010388)3.71557035
30negative regulation of protein localization to cell surface (GO:2000009)3.68689584
31protein localization to endosome (GO:0036010)3.67058309
32establishment of mitochondrion localization (GO:0051654)3.67027768
33protein localization to kinetochore (GO:0034501)3.64342763
34apical protein localization (GO:0045176)3.61831092
35regulation of collateral sprouting (GO:0048670)3.60659130
36pore complex assembly (GO:0046931)3.59883545
37glycerophospholipid catabolic process (GO:0046475)3.59861486
38mannosylation (GO:0097502)3.56390990
39paraxial mesoderm development (GO:0048339)3.56041248
40isoprenoid biosynthetic process (GO:0008299)3.55135669
41regulation of early endosome to late endosome transport (GO:2000641)3.51299510
42DNA unwinding involved in DNA replication (GO:0006268)3.50312349
43GPI anchor biosynthetic process (GO:0006506)3.49086039
44microtubule polymerization or depolymerization (GO:0031109)3.46162105
45asymmetric protein localization (GO:0008105)3.45838110
46regulation of NFAT protein import into nucleus (GO:0051532)3.42680509
47cerebral cortex radially oriented cell migration (GO:0021799)3.41338782
48nucleotide transmembrane transport (GO:1901679)3.39305023
49protein K11-linked deubiquitination (GO:0035871)3.38288261
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33478892
51protein deneddylation (GO:0000338)3.32164644
52GPI anchor metabolic process (GO:0006505)3.27314155
53mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.26489646
54positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.26489646
55positive regulation of chemokine secretion (GO:0090197)3.20978305
56activation of Rac GTPase activity (GO:0032863)3.16021575
57mitotic metaphase plate congression (GO:0007080)3.15161960
58chromosome condensation (GO:0030261)3.15153561
59photoreceptor cell differentiation (GO:0046530)3.12840265
60eye photoreceptor cell differentiation (GO:0001754)3.12840265
61L-methionine salvage (GO:0071267)3.12654457
62L-methionine biosynthetic process (GO:0071265)3.12654457
63amino acid salvage (GO:0043102)3.12654457
64peripheral nervous system axon ensheathment (GO:0032292)3.12196125
65myelination in peripheral nervous system (GO:0022011)3.12196125
66adherens junction assembly (GO:0034333)3.09682615
67cell-substrate adherens junction assembly (GO:0007045)3.09659478
68focal adhesion assembly (GO:0048041)3.09659478
69negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.08718673
70regulation of histone H3-K9 methylation (GO:0051570)3.08502231
71mitotic sister chromatid cohesion (GO:0007064)3.08333580
72heterochromatin organization (GO:0070828)3.07780134
73regulation of mammary gland epithelial cell proliferation (GO:0033599)3.07391725
74limb bud formation (GO:0060174)3.06148350
75long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.04719988
76substantia nigra development (GO:0021762)3.02636449
77negative regulation of myoblast differentiation (GO:0045662)3.00005705
78regulation of RNA export from nucleus (GO:0046831)2.99647567
79negative regulation of skeletal muscle tissue development (GO:0048642)2.97658297
80mRNA stabilization (GO:0048255)2.97075673
81RNA stabilization (GO:0043489)2.97075673
82long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.96447208
83negative regulation of histone methylation (GO:0031061)2.92095301
84regulation of nucleobase-containing compound transport (GO:0032239)2.91972374
85response to lipoprotein particle (GO:0055094)2.90793395
86ribosomal small subunit biogenesis (GO:0042274)2.89387720
87enteric nervous system development (GO:0048484)2.89306131
88amyloid precursor protein metabolic process (GO:0042982)2.89090418
89protein polyglutamylation (GO:0018095)2.87894770
90positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.86889689
91poly(A)+ mRNA export from nucleus (GO:0016973)2.85606398
92cortical actin cytoskeleton organization (GO:0030866)2.85164581
93cellular response to gamma radiation (GO:0071480)2.84222279
94regulation of translational fidelity (GO:0006450)2.82855454
95C-terminal protein lipidation (GO:0006501)2.82825264
96negative regulation of JUN kinase activity (GO:0043508)2.82329479
97preassembly of GPI anchor in ER membrane (GO:0016254)2.80333108
98sodium ion export (GO:0071436)2.79245773
99nuclear envelope reassembly (GO:0031468)2.78997256
100mitotic nuclear envelope reassembly (GO:0007084)2.78997256
101stress fiber assembly (GO:0043149)2.78706522
102mitotic sister chromatid segregation (GO:0000070)2.77734679
103regulation of cell proliferation involved in kidney development (GO:1901722)2.77474306
104positive regulation of nitric-oxide synthase activity (GO:0051000)2.77221871
105sister chromatid segregation (GO:0000819)2.75417769
106glial cell development (GO:0021782)2.72862465
107neurotransmitter uptake (GO:0001504)2.72820520
108peptidyl-threonine modification (GO:0018210)2.72190122
109ribosomal large subunit biogenesis (GO:0042273)2.70573089
110G1 DNA damage checkpoint (GO:0044783)2.70266006
111peptidyl-threonine phosphorylation (GO:0018107)2.70259175
112retina layer formation (GO:0010842)2.69050689
113mesenchymal cell differentiation involved in renal system development (GO:2001012)2.67708174
114mesenchymal cell differentiation involved in kidney development (GO:0072161)2.67708174
115histone phosphorylation (GO:0016572)2.67562277
116regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.67278155
117positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.67278155
118negative regulation of DNA repair (GO:0045738)2.66193865
119mesonephros development (GO:0001823)2.65231151
120regulation of DNA methylation (GO:0044030)2.63851330
121regulation of glucose import in response to insulin stimulus (GO:2001273)2.62679681
122lateral sprouting from an epithelium (GO:0060601)2.61665094
123peripheral nervous system development (GO:0007422)2.60680695
124protein localization to microtubule (GO:0035372)2.59827967
125amyloid precursor protein catabolic process (GO:0042987)2.59181178
126chromatin assembly (GO:0031497)2.59059909
127interleukin-6-mediated signaling pathway (GO:0070102)2.58744951
128positive regulation of chromosome segregation (GO:0051984)2.57488149
129myelin assembly (GO:0032288)2.57186129
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.56879651
131neuron cell-cell adhesion (GO:0007158)2.55709130
132regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54596089
133regulation of pigment cell differentiation (GO:0050932)2.54559472
134spliceosomal tri-snRNP complex assembly (GO:0000244)2.54287810
135regulation of translational termination (GO:0006449)2.53860497
136embryonic process involved in female pregnancy (GO:0060136)2.53424879
137cellular response to hepatocyte growth factor stimulus (GO:0035729)2.53237417
138response to hepatocyte growth factor (GO:0035728)2.53237417
139DNA packaging (GO:0006323)2.52381222
140planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51651488
141ER overload response (GO:0006983)2.51436517
142viral mRNA export from host cell nucleus (GO:0046784)2.51063320
143positive regulation of amino acid transport (GO:0051957)2.50535632
144estrogen biosynthetic process (GO:0006703)2.50450416
145regulation of interleukin-13 production (GO:0032656)2.50376692
146fatty-acyl-CoA biosynthetic process (GO:0046949)2.49982756
147cortical cytoskeleton organization (GO:0030865)2.48776568
148positive regulation of mitochondrial fission (GO:0090141)2.47960024
149C-terminal protein amino acid modification (GO:0018410)2.47363320
150import into cell (GO:0098657)2.46862063
151peptidyl-lysine dimethylation (GO:0018027)2.46778618
152regulation of rhodopsin mediated signaling pathway (GO:0022400)2.46690561
153adult walking behavior (GO:0007628)2.44811073
154L-amino acid import (GO:0043092)2.44395708
155intraciliary transport (GO:0042073)2.43839737
156labyrinthine layer development (GO:0060711)2.43688088
157amino acid import (GO:0043090)2.43189948
158DNA integration (GO:0015074)2.42474197
159oxidative demethylation (GO:0070989)2.42117164
160positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.41932030
161formation of translation preinitiation complex (GO:0001731)2.41828695
162fatty-acyl-CoA metabolic process (GO:0035337)2.40766021
163membrane assembly (GO:0071709)2.40585953
164histone H2B ubiquitination (GO:0033523)2.39435939
165single strand break repair (GO:0000012)2.39011206
166regulation of chemokine secretion (GO:0090196)2.38989866
167dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.37643089
168cellular response to arsenic-containing substance (GO:0071243)2.36576532
169histone H3-K36 demethylation (GO:0070544)2.34549975
170protein export from nucleus (GO:0006611)2.33755866
171receptor recycling (GO:0001881)2.31678433
172insulin-like growth factor receptor signaling pathway (GO:0048009)2.30502282
173osteoclast differentiation (GO:0030316)2.29727431
174mitotic G1 DNA damage checkpoint (GO:0031571)2.29025154
175protein localization to chromosome (GO:0034502)2.28562222
176neuromuscular process controlling balance (GO:0050885)2.27998250
177establishment of integrated proviral latency (GO:0075713)2.27434702
178establishment of chromosome localization (GO:0051303)2.26877095
179mitotic nuclear envelope disassembly (GO:0007077)2.26449633
180gonadal mesoderm development (GO:0007506)2.26363921
181membrane disassembly (GO:0030397)2.25127881
182nuclear envelope disassembly (GO:0051081)2.25127881
183regulation of mitotic spindle organization (GO:0060236)2.21480212
184regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.21046108
185regulation of chromosome segregation (GO:0051983)2.20988026
186regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.20328404
187ribosome assembly (GO:0042255)2.19004885
188cell-substrate junction assembly (GO:0007044)2.17896306
189metaphase plate congression (GO:0051310)2.17798850
190mitotic G1/S transition checkpoint (GO:0044819)2.16126839
191glucocorticoid receptor signaling pathway (GO:0042921)2.16085905
192mitochondrial DNA metabolic process (GO:0032042)2.13906618
193apoptotic cell clearance (GO:0043277)2.11662224
194regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.10652549
195mating behavior (GO:0007617)2.10072188
196positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.10036883
197negative regulation of homotypic cell-cell adhesion (GO:0034111)2.08321396
198G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.07655855

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.06833678
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.87187896
3GBX2_23144817_ChIP-Seq_PC3_Human4.10331214
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.99990770
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.26370096
6MYC_22102868_ChIP-Seq_BL_Human3.25662293
7TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.74513448
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73203688
9AR_21909140_ChIP-Seq_LNCAP_Human2.68835315
10* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.66448032
11VDR_21846776_ChIP-Seq_THP-1_Human2.64902759
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64416044
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.56738521
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50798286
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45096297
16TAF15_26573619_Chip-Seq_HEK293_Human2.41474639
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.39720709
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.31661851
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26114389
20* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21979246
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18170264
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13774498
23* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.12082125
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.11158631
25FUS_26573619_Chip-Seq_HEK293_Human2.10950752
26KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10866164
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09085372
28BMI1_23680149_ChIP-Seq_NPCS_Mouse2.07699863
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07681747
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03416351
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01491429
32AR_21572438_ChIP-Seq_LNCaP_Human1.99835123
33IRF1_19129219_ChIP-ChIP_H3396_Human1.99589508
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97496686
35EWS_26573619_Chip-Seq_HEK293_Human1.96069763
36TCF7_22412390_ChIP-Seq_EML_Mouse1.93043229
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92439886
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89811142
39RNF2_27304074_Chip-Seq_NSC_Mouse1.88419132
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87049143
41VDR_22108803_ChIP-Seq_LS180_Human1.86843284
42KDM2B_26808549_Chip-Seq_K562_Human1.84570470
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82429380
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80441984
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80225121
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.79490920
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79456407
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79185900
49KDM2B_26808549_Chip-Seq_DND41_Human1.79060410
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78586023
51* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.76316012
52* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75731963
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.75390570
54ER_23166858_ChIP-Seq_MCF-7_Human1.71101374
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69266275
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68813103
57* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67863485
58* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.65522988
59P300_19829295_ChIP-Seq_ESCs_Human1.64336756
60CLOCK_20551151_ChIP-Seq_293T_Human1.63852775
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59438584
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.58003768
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57749532
64* ELK3_25401928_ChIP-Seq_HUVEC_Human1.57710398
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57094932
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.56693221
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55881319
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55606429
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55118924
70P300_18555785_Chip-Seq_ESCs_Mouse1.55118366
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54653170
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.54617855
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54001353
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53355525
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52799976
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52797062
77* UBF1/2_26484160_Chip-Seq_HMECs_Human1.51805102
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.51067221
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50216180
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49666205
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49338219
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48355464
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48325047
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47388596
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.47325131
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.47114687
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46921281
88* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46145646
89LXR_22292898_ChIP-Seq_THP-1_Human1.45624925
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.45156850
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43548391
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.43449077
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43367455
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41410878
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40096074
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39495251
97NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39278937
98VDR_24763502_ChIP-Seq_THP-1_Human1.39030884
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.38299465
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.37817076
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.37033391
102* RACK7_27058665_Chip-Seq_MCF-7_Human1.36020541
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35703677
104SRF_21415370_ChIP-Seq_HL-1_Mouse1.35274090
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35268027
106EZH2_22144423_ChIP-Seq_EOC_Human1.34925764
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.34662173
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34641098
109PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34555941
110CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34505303
111MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32726093
112* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.32467429
113* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32124626
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.32075675
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31406407
116TAL1_26923725_Chip-Seq_HPCs_Mouse1.31049165
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29898187
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29505295
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29016720
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28863103
121P53_22387025_ChIP-Seq_ESCs_Mouse1.28238964
122SOX2_18555785_Chip-Seq_ESCs_Mouse1.27640077
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27617612
124CHD1_26751641_Chip-Seq_LNCaP_Human1.26072676
125* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25906290
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25316141
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25316141
128KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25316141
129SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24881940
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24335893
131SOX9_26525672_Chip-Seq_HEART_Mouse1.23797533
132MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23390753
133STAT3_23295773_ChIP-Seq_U87_Human1.22884240
134RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22570511
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22290626
136GATA1_26923725_Chip-Seq_HPCs_Mouse1.22264074
137WT1_19549856_ChIP-ChIP_CCG9911_Human1.20573188
138FLI1_27457419_Chip-Seq_LIVER_Mouse1.20068467
139RNF2_27304074_Chip-Seq_ESCs_Mouse1.19406976
140SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19056450
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18702794
142SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18583179
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18549253
144ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17687782
145JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16763951
146NMYC_18555785_Chip-Seq_ESCs_Mouse1.15523310
147TCF4_23295773_ChIP-Seq_U87_Human1.14848092
148OCT4_18555785_Chip-Seq_ESCs_Mouse1.14595131
149SOX2_16153702_ChIP-ChIP_HESCs_Human1.14581128
150TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14345553
151SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13319265
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12404749
153TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11695374
154NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11413975
155PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11060977
156TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.10422659
157P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10220493
158PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09294094
159SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09112941
160RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08578124
161SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07938553
162XRN2_22483619_ChIP-Seq_HELA_Human1.07878279
163SMAD4_21799915_ChIP-Seq_A2780_Human1.06834830
164E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06773412
165LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05668901
166JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05665043
167EST1_17652178_ChIP-ChIP_JURKAT_Human1.05555856
168KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05418460
169EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05244828
170RARB_27405468_Chip-Seq_BRAIN_Mouse1.04763811
171JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04690261
172RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04646184
173EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04107303
174RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04107303
175SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04099105
176ERG_21242973_ChIP-ChIP_JURKAT_Human1.03885963
177RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03667359
178HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02812939
179* ATF3_27146783_Chip-Seq_COLON_Human1.02751600
180ZFX_18555785_Chip-Seq_ESCs_Mouse1.02707075
181NFE2_27457419_Chip-Seq_LIVER_Mouse1.02589095
182TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01985290
183NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00975440
184AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00760613
185GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00710775
186TP53_20018659_ChIP-ChIP_R1E_Mouse1.00451622
187TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00099281
188CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98905405
189MAF_26560356_Chip-Seq_TH1_Human0.98756170
190* RING1B_27294783_Chip-Seq_NPCs_Mouse0.98579234
191TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97435174
192* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96446909
193SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96263976
194EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95713446
195PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94440101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.46482780
2MP0003705_abnormal_hypodermis_morpholog4.30908113
3MP0000920_abnormal_myelination4.05387087
4MP0010234_abnormal_vibrissa_follicle3.68259015
5MP0010352_gastrointestinal_tract_polyps3.09708830
6MP0003136_yellow_coat_color2.89663524
7MP0000566_synostosis2.78523817
8MP0003950_abnormal_plasma_membrane2.76901921
9MP0003880_abnormal_central_pattern2.67579451
10MP0001905_abnormal_dopamine_level2.66582172
11MP0002877_abnormal_melanocyte_morpholog2.51983978
12MP0001529_abnormal_vocalization2.42205608
13MP0000537_abnormal_urethra_morphology2.41668385
14MP0003693_abnormal_embryo_hatching2.41025780
15MP0005409_darkened_coat_color2.38454372
16MP0001849_ear_inflammation2.38175246
17MP0003941_abnormal_skin_development2.35377663
18MP0008057_abnormal_DNA_replication2.34282540
19MP0003091_abnormal_cell_migration2.33397929
20MP0002272_abnormal_nervous_system2.21025398
21MP0004233_abnormal_muscle_weight2.16313651
22MP0003077_abnormal_cell_cycle2.14968531
23MP0004134_abnormal_chest_morphology2.07623965
24MP0005451_abnormal_body_composition2.07245916
25MP0001188_hyperpigmentation2.04476106
26MP0004142_abnormal_muscle_tone2.01271285
27MP0004185_abnormal_adipocyte_glucose2.01000717
28MP0005076_abnormal_cell_differentiation1.99461030
29MP0001485_abnormal_pinna_reflex1.94031766
30MP0004147_increased_porphyrin_level1.92994188
31MP0003111_abnormal_nucleus_morphology1.92269061
32MP0006292_abnormal_olfactory_placode1.90655298
33MP0004742_abnormal_vestibular_system1.87257868
34MP0000733_abnormal_muscle_development1.85112601
35MP0004957_abnormal_blastocyst_morpholog1.82398449
36MP0000778_abnormal_nervous_system1.82164597
37MP0004885_abnormal_endolymph1.76557730
38MP0009053_abnormal_anal_canal1.76335701
39MP0000350_abnormal_cell_proliferation1.75174980
40MP0003453_abnormal_keratinocyte_physiol1.72488040
41MP0001486_abnormal_startle_reflex1.69348364
42MP0010094_abnormal_chromosome_stability1.67688959
43MP0004270_analgesia1.65127278
44MP0001730_embryonic_growth_arrest1.63248309
45MP0003632_abnormal_nervous_system1.62571282
46MP0009046_muscle_twitch1.59321751
47MP0003634_abnormal_glial_cell1.59318444
48MP0005646_abnormal_pituitary_gland1.57492909
49MP0001348_abnormal_lacrimal_gland1.57480390
50MP0008877_abnormal_DNA_methylation1.57306121
51MP0003890_abnormal_embryonic-extraembry1.56670086
52MP0000015_abnormal_ear_pigmentation1.56625669
53MP0003123_paternal_imprinting1.56069442
54MP0004859_abnormal_synaptic_plasticity1.55126322
55MP0000372_irregular_coat_pigmentation1.52997990
56MP0002938_white_spotting1.52926602
57MP0009672_abnormal_birth_weight1.52230200
58MP0010030_abnormal_orbit_morphology1.50257499
59MP0003690_abnormal_glial_cell1.49663524
60MP0004808_abnormal_hematopoietic_stem1.48304998
61MP0001177_atelectasis1.48252417
62MP0002796_impaired_skin_barrier1.46311006
63MP0002089_abnormal_postnatal_growth/wei1.43170718
64MP0002064_seizures1.42352140
65MP0002229_neurodegeneration1.41522688
66MP0001963_abnormal_hearing_physiology1.40288198
67MP0000428_abnormal_craniofacial_morphol1.39434534
68MP0005058_abnormal_lysosome_morphology1.35986961
69MP0005645_abnormal_hypothalamus_physiol1.35225655
70MP0000749_muscle_degeneration1.32195077
71MP0010307_abnormal_tumor_latency1.29348848
72MP0005410_abnormal_fertilization1.29293169
73MP0000026_abnormal_inner_ear1.29226229
74MP0001672_abnormal_embryogenesis/_devel1.25778580
75MP0005380_embryogenesis_phenotype1.25778580
76MP0005075_abnormal_melanosome_morpholog1.24990080
77MP0009840_abnormal_foam_cell1.24077193
78MP0001340_abnormal_eyelid_morphology1.23922240
79MP0002006_tumorigenesis1.23876018
80MP0008260_abnormal_autophagy1.22688362
81MP0009250_abnormal_appendicular_skeleto1.21533468
82MP0005503_abnormal_tendon_morphology1.21043070
83MP0008438_abnormal_cutaneous_collagen1.18514966
84MP0003329_amyloid_beta_deposits1.15680778
85MP0002882_abnormal_neuron_morphology1.15637075
86MP0002009_preneoplasia1.15298355
87MP0002752_abnormal_somatic_nervous1.15020154
88MP0002572_abnormal_emotion/affect_behav1.14982043
89MP0003122_maternal_imprinting1.14552595
90MP0000955_abnormal_spinal_cord1.12673724
91MP0005551_abnormal_eye_electrophysiolog1.12652730
92MP0003938_abnormal_ear_development1.11990060
93MP0001697_abnormal_embryo_size1.11753702
94MP0009745_abnormal_behavioral_response1.11386496
95MP0002734_abnormal_mechanical_nocicepti1.11341118
96MP0001299_abnormal_eye_distance/1.10615805
97MP0002085_abnormal_embryonic_tissue1.10572909
98MP0004381_abnormal_hair_follicle1.10220066
99MP0000678_abnormal_parathyroid_gland1.10198787
100MP0003631_nervous_system_phenotype1.09750424
101MP0002092_abnormal_eye_morphology1.09485176
102MP0001727_abnormal_embryo_implantation1.09098551
103MP0001986_abnormal_taste_sensitivity1.08290183
104MP0000049_abnormal_middle_ear1.07522249
105MP0003303_peritoneal_inflammation1.06539139
106MP0002084_abnormal_developmental_patter1.05518152
107MP0005257_abnormal_intraocular_pressure1.05442666
108MP0002166_altered_tumor_susceptibility1.05404044
109MP0003566_abnormal_cell_adhesion1.04637611
110MP0003300_gastrointestinal_ulcer1.04053464
111MP0000762_abnormal_tongue_morphology1.02241050
112MP0002080_prenatal_lethality1.01741245
113MP0009379_abnormal_foot_pigmentation1.01469896
114MP0003937_abnormal_limbs/digits/tail_de1.00872062
115MP0003984_embryonic_growth_retardation1.00532711
116MP0002086_abnormal_extraembryonic_tissu0.98933535
117MP0005386_behavior/neurological_phenoty0.98901301
118MP0004924_abnormal_behavior0.98901301
119MP0008569_lethality_at_weaning0.98502369
120MP0001502_abnormal_circadian_rhythm0.97910339
121MP0000003_abnormal_adipose_tissue0.97874868
122MP0005621_abnormal_cell_physiology0.96712912
123MP0002088_abnormal_embryonic_growth/wei0.96464672
124MP0002067_abnormal_sensory_capabilities0.95163409
125MP0002249_abnormal_larynx_morphology0.94563110
126MP0002066_abnormal_motor_capabilities/c0.94302706
127MP0004133_heterotaxia0.93059106
128MP0002063_abnormal_learning/memory/cond0.92269457
129MP0005195_abnormal_posterior_eye0.91821873
130MP0001293_anophthalmia0.91525563
131MP0000631_abnormal_neuroendocrine_gland0.90670422
132MP0003115_abnormal_respiratory_system0.88858937
133MP0003755_abnormal_palate_morphology0.88737666
134MP0005253_abnormal_eye_physiology0.88173434
135MP0005408_hypopigmentation0.87967024
136MP0003385_abnormal_body_wall0.87909221
137MP0001346_abnormal_lacrimal_gland0.86596822
138MP0008932_abnormal_embryonic_tissue0.86589803
139MP0003806_abnormal_nucleotide_metabolis0.85822547
140MP0003121_genomic_imprinting0.85107145
141MP0003635_abnormal_synaptic_transmissio0.84736011
142MP0002160_abnormal_reproductive_system0.84723204
143MP0000432_abnormal_head_morphology0.84295200
144MP0004197_abnormal_fetal_growth/weight/0.84214811
145MP0002896_abnormal_bone_mineralization0.83356564
146MP0000604_amyloidosis0.82571654
147MP0002697_abnormal_eye_size0.82567312
148MP0000759_abnormal_skeletal_muscle0.81966689
149MP0000681_abnormal_thyroid_gland0.81577799
150MP0000516_abnormal_urinary_system0.80998740
151MP0005367_renal/urinary_system_phenotyp0.80998740
152MP0000534_abnormal_ureter_morphology0.80818604
153MP0002998_abnormal_bone_remodeling0.80505465
154MP0005501_abnormal_skin_physiology0.80343404
155MP0003942_abnormal_urinary_system0.80310446
156MP0002751_abnormal_autonomic_nervous0.80090591
157MP0002876_abnormal_thyroid_physiology0.79644949
158MP0000462_abnormal_digestive_system0.79460356
159MP0000490_abnormal_crypts_of0.79055953
160MP0000747_muscle_weakness0.78374890
161MP0009384_cardiac_valve_regurgitation0.77108332
162MP0003698_abnormal_male_reproductive0.77050209
163MP0008789_abnormal_olfactory_epithelium0.76933857
164MP0003283_abnormal_digestive_organ0.76492542
165MP0000313_abnormal_cell_death0.76473514
166MP0004510_myositis0.76265425
167MP0005623_abnormal_meninges_morphology0.75793241
168MP0002133_abnormal_respiratory_system0.74539218
169MP0005388_respiratory_system_phenotype0.74539218
170MP0005666_abnormal_adipose_tissue0.74115262
171MP0001970_abnormal_pain_threshold0.74091069
172MP0003935_abnormal_craniofacial_develop0.73308172
173MP0002210_abnormal_sex_determination0.73155680
174MP0003943_abnormal_hepatobiliary_system0.72904822
175MP0003191_abnormal_cellular_cholesterol0.72314695
176MP0002108_abnormal_muscle_morphology0.71886176
177MP0003861_abnormal_nervous_system0.71479784
178MP0005375_adipose_tissue_phenotype0.71267407
179MP0002735_abnormal_chemical_nociception0.71185906
180MP0002152_abnormal_brain_morphology0.71025157
181MP0003315_abnormal_perineum_morphology0.68678956
182MP0002111_abnormal_tail_morphology0.68152766
183MP0002269_muscular_atrophy0.64036543

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.73932350
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.73932350
3Abnormality of the corticospinal tract (HP:0002492)3.80583581
4Parakeratosis (HP:0001036)3.73735637
5Cerebral hypomyelination (HP:0006808)3.68164237
6Sensory axonal neuropathy (HP:0003390)3.57278302
7Increased serum pyruvate (HP:0003542)3.33776043
8Abnormality of glycolysis (HP:0004366)3.33776043
9Asymmetry of the thorax (HP:0001555)3.03633654
10Upper motor neuron abnormality (HP:0002127)3.01282447
11Hyperacusis (HP:0010780)2.87009989
12Pancreatic islet-cell hyperplasia (HP:0004510)2.86851850
13Abnormal hair whorl (HP:0010721)2.84223540
14Alacrima (HP:0000522)2.81503694
15Abnormal auditory evoked potentials (HP:0006958)2.80918857
16Patchy hypopigmentation of hair (HP:0011365)2.79710852
17White forelock (HP:0002211)2.78447710
18Intestinal atresia (HP:0011100)2.77947795
19Adrenal hypoplasia (HP:0000835)2.73379113
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.71709794
21Pheochromocytoma (HP:0002666)2.68706052
22Vaginal atresia (HP:0000148)2.62901910
23Rectovaginal fistula (HP:0000143)2.60785033
24Rectal fistula (HP:0100590)2.60785033
25Ankyloglossia (HP:0010296)2.59881201
26Cerebral inclusion bodies (HP:0100314)2.59740723
27Genital tract atresia (HP:0001827)2.57481540
28Achilles tendon contracture (HP:0001771)2.57246794
29Absent septum pellucidum (HP:0001331)2.54459978
30Thickened helices (HP:0000391)2.52591888
31Uterine leiomyosarcoma (HP:0002891)2.52036384
32Leiomyosarcoma (HP:0100243)2.52036384
33Insomnia (HP:0100785)2.50876585
34Nephroblastoma (Wilms tumor) (HP:0002667)2.50054713
35Hypoplastic left heart (HP:0004383)2.49455139
36Type I transferrin isoform profile (HP:0003642)2.47662340
37Medial flaring of the eyebrow (HP:0010747)2.47606486
38Embryonal renal neoplasm (HP:0011794)2.46954939
39Progressive external ophthalmoplegia (HP:0000590)2.45279747
40Retinal dysplasia (HP:0007973)2.44907329
41Leukodystrophy (HP:0002415)2.44441040
42Anomalous pulmonary venous return (HP:0010772)2.42567673
43Peripheral hypomyelination (HP:0007182)2.40774612
44Apathy (HP:0000741)2.37858162
45Hypoplastic heart (HP:0001961)2.37334396
46Multiple lipomas (HP:0001012)2.36826957
47Premature skin wrinkling (HP:0100678)2.36228031
48Gait imbalance (HP:0002141)2.34676612
49Dysmetric saccades (HP:0000641)2.34638003
50Upper limb muscle weakness (HP:0003484)2.33910372
51Septo-optic dysplasia (HP:0100842)2.33857360
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33455982
53Abnormality of the septum pellucidum (HP:0007375)2.33226092
54Akinesia (HP:0002304)2.32027830
55Neuroendocrine neoplasm (HP:0100634)2.31418033
56Atonic seizures (HP:0010819)2.31093969
57Intestinal fistula (HP:0100819)2.30380701
58Gastrointestinal atresia (HP:0002589)2.30032187
59Nephrogenic diabetes insipidus (HP:0009806)2.29301689
60Morphological abnormality of the inner ear (HP:0011390)2.25770028
61Congenital primary aphakia (HP:0007707)2.25222657
62Distal upper limb amyotrophy (HP:0007149)2.23058952
63Upper limb amyotrophy (HP:0009129)2.23058952
64Anteriorly placed anus (HP:0001545)2.22536950
65Autoamputation (HP:0001218)2.21607122
66Diminished motivation (HP:0000745)2.21241842
67Decreased lacrimation (HP:0000633)2.20741047
68Deep philtrum (HP:0002002)2.20480783
69Shoulder girdle muscle weakness (HP:0003547)2.20447073
70Aplasia/Hypoplasia of the tibia (HP:0005772)2.18024570
71Onion bulb formation (HP:0003383)2.17722204
72Shallow orbits (HP:0000586)2.16408350
73Myelomeningocele (HP:0002475)2.16347118
74Hand muscle atrophy (HP:0009130)2.15120772
75Papillary thyroid carcinoma (HP:0002895)2.14874507
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.12844579
77Optic nerve hypoplasia (HP:0000609)2.11226662
78Obstructive sleep apnea (HP:0002870)2.09994318
79Abnormality of the pulmonary veins (HP:0011718)2.08945675
80Cortical dysplasia (HP:0002539)2.07097028
81Abnormality of incisor morphology (HP:0011063)2.06505377
82Abnormality of the Achilles tendon (HP:0005109)2.05133457
83Segmental peripheral demyelination/remyelination (HP:0003481)2.04041169
84Abnormal lung lobation (HP:0002101)2.03500430
85Neurofibrillary tangles (HP:0002185)2.02720860
86Congenital ichthyosiform erythroderma (HP:0007431)2.02485291
873-Methylglutaconic aciduria (HP:0003535)2.02080574
88Acute necrotizing encephalopathy (HP:0006965)2.01948918
89Transitional cell carcinoma of the bladder (HP:0006740)2.01669425
90Short tibia (HP:0005736)2.00479317
91Abnormality of oral frenula (HP:0000190)2.00280333
92Hepatocellular necrosis (HP:0001404)1.99853724
93Vaginal fistula (HP:0004320)1.98671391
94Coronal craniosynostosis (HP:0004440)1.96861371
95Insidious onset (HP:0003587)1.96483338
96Termporal pattern (HP:0011008)1.96483338
97Broad face (HP:0000283)1.96343928
98Duplicated collecting system (HP:0000081)1.96062000
99Subacute progressive viral hepatitis (HP:0006572)1.94625665
100Abnormality of the renal collecting system (HP:0004742)1.94493662
101Gastrointestinal stroma tumor (HP:0100723)1.92754412
102Hyperparathyroidism (HP:0000843)1.92742714
103Increased nuchal translucency (HP:0010880)1.91897287
104Clumsiness (HP:0002312)1.91751347
105Missing ribs (HP:0000921)1.91675907
106Distal lower limb amyotrophy (HP:0008944)1.91586093
107Renal cell carcinoma (HP:0005584)1.91231808
108Abnormality of the thoracic spine (HP:0100711)1.90872317
109Arnold-Chiari malformation (HP:0002308)1.90688717
110Thin bony cortex (HP:0002753)1.90410747
111Mutism (HP:0002300)1.90309397
112Lower limb amyotrophy (HP:0007210)1.90191309
113Prolonged neonatal jaundice (HP:0006579)1.88939693
114Fetal akinesia sequence (HP:0001989)1.88828439
115Poor coordination (HP:0002370)1.88141595
116Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87957656
117Neuronal loss in central nervous system (HP:0002529)1.87456876
118Cupped ear (HP:0000378)1.85891743
119Hammertoe (HP:0001765)1.84830476
120Abnormality of the labia minora (HP:0012880)1.84615988
121Diminished movement (HP:0002374)1.84613045
122Epileptic encephalopathy (HP:0200134)1.83753492
123Lower limb asymmetry (HP:0100559)1.83739927
124Bladder neoplasm (HP:0009725)1.83240955
125Bladder carcinoma (HP:0002862)1.83240955
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.83077396
127Osteolytic defects of the hand bones (HP:0009699)1.83077396
128Tetraparesis (HP:0002273)1.82271683
129Mitochondrial inheritance (HP:0001427)1.82255038
130Turricephaly (HP:0000262)1.82141554
131Abnormality of cochlea (HP:0000375)1.80340646
132True hermaphroditism (HP:0010459)1.80198362
133Spastic diplegia (HP:0001264)1.79865829
134Ulnar bowing (HP:0003031)1.79815297
135Viral hepatitis (HP:0006562)1.79379376
136Hypoplastic pelvis (HP:0008839)1.79355417
137Pelvic girdle muscle weakness (HP:0003749)1.79180716
138Disinhibition (HP:0000734)1.78402641
139Germ cell neoplasia (HP:0100728)1.78211162
140Premature rupture of membranes (HP:0001788)1.77275290
141Overriding aorta (HP:0002623)1.76815896
142Poor speech (HP:0002465)1.76468660
143Relative macrocephaly (HP:0004482)1.76424897
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75880592
145Abnormality of chromosome segregation (HP:0002916)1.75429863
146Split foot (HP:0001839)1.75308808
147CNS hypomyelination (HP:0003429)1.74380437
148Thoracic kyphosis (HP:0002942)1.74220638
149Foot dorsiflexor weakness (HP:0009027)1.73543837
150Progressive muscle weakness (HP:0003323)1.72979748
151Deep palmar crease (HP:0006191)1.72928503
152Limb dystonia (HP:0002451)1.72495105
153Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72393776
154Recurrent corneal erosions (HP:0000495)1.72156395
155Urinary urgency (HP:0000012)1.72092049
156Type 2 muscle fiber atrophy (HP:0003554)1.71710456
157Heterotopia (HP:0002282)1.71493848
158Esophageal atresia (HP:0002032)1.71034561
159Dysphonia (HP:0001618)1.70582295
160Spastic gait (HP:0002064)1.69664739
161Cellulitis (HP:0100658)1.69578488
162Disproportionate tall stature (HP:0001519)1.69465010
163Abnormality of the phalanges of the hallux (HP:0010057)1.69232905
164Pointed chin (HP:0000307)1.69056043
165Conical tooth (HP:0000698)1.68949835
166Methylmalonic acidemia (HP:0002912)1.68910797
167Duplication of thumb phalanx (HP:0009942)1.68222863
168Capillary hemangiomas (HP:0005306)1.68127782
169Hepatosplenomegaly (HP:0001433)1.68077380
170Scanning speech (HP:0002168)1.67611429
171Diastasis recti (HP:0001540)1.67130365
172Abnormal mitochondria in muscle tissue (HP:0008316)1.65489649
173Selective tooth agenesis (HP:0001592)1.64865236
174Malignant gastrointestinal tract tumors (HP:0006749)1.64804468
175Gastrointestinal carcinoma (HP:0002672)1.64804468
176Syringomyelia (HP:0003396)1.64093850
177Spinal cord lesions (HP:0100561)1.64093850
178Long palpebral fissure (HP:0000637)1.63795345
179Abnormality of the distal phalanx of the thumb (HP:0009617)1.62824146
180Facial hemangioma (HP:0000329)1.61913231
181Vertebral arch anomaly (HP:0008438)1.61408220
182Elfin facies (HP:0004428)1.61258879
183Cubitus valgus (HP:0002967)1.60562200
184Lower limb hyperreflexia (HP:0002395)1.59899866
185Pseudobulbar signs (HP:0002200)1.58589009
186Spinal cord compression (HP:0002176)1.58230414
187Multiple enchondromatosis (HP:0005701)1.57025557
188Mitral regurgitation (HP:0001653)1.56701959
189Loss of speech (HP:0002371)1.55985562
190High anterior hairline (HP:0009890)1.53951007
191Deviation of the thumb (HP:0009603)1.53343624
192Distal lower limb muscle weakness (HP:0009053)1.53142016
193Aplasia of the phalanges of the hand (HP:0009802)1.52636405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B7.37124846
2CASK4.02786334
3STK393.96447394
4MAP3K93.70882935
5TRIB33.30766096
6OXSR12.98736828
7CDK122.81448656
8SMG12.73926102
9LATS22.69990246
10ARAF2.55731580
11EEF2K2.53059150
12YES12.51805011
13MAP3K102.50840806
14AKT32.37733921
15BCR2.35228752
16MAP3K132.26978493
17MKNK12.09777777
18EPHB12.09409586
19NME22.05231066
20UHMK11.89776229
21NEK61.85222423
22PKN11.83247702
23PDGFRA1.81138404
24MKNK21.70591839
25TYRO31.70281779
26IRAK31.66797914
27PRKD31.61941726
28TRPM71.60333946
29TNIK1.58297689
30PINK11.57552636
31KSR21.55299063
32TTN1.55222293
33PBK1.51313468
34DYRK21.51203228
35MAPKAPK51.48987601
36SGK2231.48264333
37SGK4941.48264333
38NEK91.46789572
39CDC71.45309392
40RIPK41.44061147
41CLK11.37181804
42WNK41.35563011
43TAF11.31222049
44CDK191.28701428
45BRD41.28669512
46LIMK11.28211275
47MAP3K81.26176177
48SIK11.19941486
49BMPR21.16656809
50PLK21.15834114
51MAPK151.13875238
52ERBB31.13641629
53MST41.10622430
54CAMK2B1.10220081
55SCYL21.06962838
56MUSK1.06352888
57CDK71.04515028
58WEE11.04445309
59PNCK1.04225311
60STK31.04108508
61TTK1.03663646
62ROCK21.02784349
63CAMK1D0.99790008
64MAP2K70.98983776
65CAMKK10.98634604
66MTOR0.96850591
67MAPK130.96407441
68WNK10.94966398
69BUB10.94526704
70PLK30.93649839
71MOS0.93417531
72PASK0.93122332
73MET0.92589776
74CAMK1G0.89305506
75CSNK1G30.88478685
76FGFR20.87823964
77BMPR1B0.87661473
78CSNK1A1L0.87376881
79ZAK0.86488895
80CAMK2D0.85864429
81TAOK20.83252119
82DMPK0.82975099
83ICK0.81935049
84STK160.80523245
85SGK20.78031658
86OBSCN0.77576783
87SRPK10.76791328
88MAP3K60.76587178
89PAK40.76539669
90CDK60.76375397
91BRAF0.75300726
92GSK3A0.75129125
93RAF10.75019882
94CHEK20.73913133
95PKN20.72978400
96FGR0.72616826
97PIK3CA0.71691630
98LMTK20.71645299
99TNK20.71228204
100RPS6KB20.70957948
101CSNK1G10.70530242
102NEK20.69458371
103CDK80.68876769
104PAK20.67452086
105FGFR40.67245104
106CCNB10.66871551
107CAMK2G0.64653392
108ALK0.63137799
109MELK0.62688199
110ADRBK20.62300621
111SIK20.62274293
112LATS10.61898973
113INSRR0.61695536
114STK38L0.61003465
115KSR10.60912331
116VRK10.60619278
117PDPK10.60125959
118DDR20.59781738
119CAMK2A0.59495598
120RPS6KA20.59298211
121NTRK10.58733004
122PIM20.58258425
123PTK20.57801911
124STK240.57463678
125LRRK20.57022243
126TSSK60.55188866
127CDK40.54618296
128PRKCE0.54322165
129EIF2AK20.54034248
130STK380.53431488
131MAPK100.52909269
132AURKA0.52316947
133PDGFRB0.51320094
134STK40.49106030
135AKT20.47665355
136MAP3K10.46288885
137CDK50.45446844
138BRSK20.45294792
139BRSK10.44530291
140PRKCH0.44174309
141DAPK30.43510069
142NEK10.42747896
143IRAK20.42611549
144CDK90.41813008
145PRKACB0.41566444
146SGK30.39945562
147RPS6KA10.39113993
148CAMKK20.38840887
149CDK180.38797383
150CDK140.38023556
151CSNK1G20.37833844
152RIPK10.37616699
153EPHA20.37580497
154TXK0.37248915
155MAP3K140.36179824
156PLK40.35171457
157ERBB40.34971081
158CDK150.33507601
159MYLK0.30655559
160MARK10.29092198
161RPS6KA60.28871736
162MAPKAPK20.28858604
163CSNK1A10.28570633
164PRKCQ0.28127615
165RPS6KC10.27583477
166RPS6KL10.27583477
167CDK11A0.27147580
168RPS6KA50.27116177
169PRKG10.26979967
170SGK10.26896012
171EIF2AK30.26078102
172NUAK10.25530878
173RPS6KB10.25410261
174PAK10.24858878
175PRKACA0.24455226

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.82704354
2Fatty acid elongation_Homo sapiens_hsa000624.65558589
3Steroid biosynthesis_Homo sapiens_hsa001004.40511877
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.48040199
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.94969796
6Vitamin B6 metabolism_Homo sapiens_hsa007502.79710679
7Ether lipid metabolism_Homo sapiens_hsa005652.67311479
8Protein export_Homo sapiens_hsa030602.34071583
9Oxidative phosphorylation_Homo sapiens_hsa001902.11131507
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.06338359
11Chronic myeloid leukemia_Homo sapiens_hsa052202.01436276
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98407138
13B cell receptor signaling pathway_Homo sapiens_hsa046621.85426603
14Thyroid cancer_Homo sapiens_hsa052161.82722435
15Base excision repair_Homo sapiens_hsa034101.79356810
16Basal transcription factors_Homo sapiens_hsa030221.72148701
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.70743235
18Endometrial cancer_Homo sapiens_hsa052131.67812959
19* Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65291404
20Sulfur metabolism_Homo sapiens_hsa009201.65188460
21Parkinsons disease_Homo sapiens_hsa050121.65053038
22Mismatch repair_Homo sapiens_hsa034301.63214969
23Non-small cell lung cancer_Homo sapiens_hsa052231.62767783
24Systemic lupus erythematosus_Homo sapiens_hsa053221.59367452
25Arachidonic acid metabolism_Homo sapiens_hsa005901.57920203
26Glioma_Homo sapiens_hsa052141.57546184
27Phototransduction_Homo sapiens_hsa047441.49123044
28Homologous recombination_Homo sapiens_hsa034401.48695038
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46325945
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.46305035
31Bladder cancer_Homo sapiens_hsa052191.46257537
32Viral carcinogenesis_Homo sapiens_hsa052031.45984247
33Sphingolipid metabolism_Homo sapiens_hsa006001.45245574
34Long-term potentiation_Homo sapiens_hsa047201.44062478
35Pancreatic cancer_Homo sapiens_hsa052121.43522138
36Renal cell carcinoma_Homo sapiens_hsa052111.40789705
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.37745698
38Alcoholism_Homo sapiens_hsa050341.36223267
39Acute myeloid leukemia_Homo sapiens_hsa052211.35064651
40mTOR signaling pathway_Homo sapiens_hsa041501.34225912
41Collecting duct acid secretion_Homo sapiens_hsa049661.33548784
42MicroRNAs in cancer_Homo sapiens_hsa052061.32696928
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30229371
44Adherens junction_Homo sapiens_hsa045201.29867135
45Prion diseases_Homo sapiens_hsa050201.29297282
46Proteasome_Homo sapiens_hsa030501.28742473
47Colorectal cancer_Homo sapiens_hsa052101.27305722
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25521449
49VEGF signaling pathway_Homo sapiens_hsa043701.22890143
50Axon guidance_Homo sapiens_hsa043601.22668525
51Small cell lung cancer_Homo sapiens_hsa052221.22562011
52Vibrio cholerae infection_Homo sapiens_hsa051101.22558268
53Proteoglycans in cancer_Homo sapiens_hsa052051.22135333
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21599259
55Serotonergic synapse_Homo sapiens_hsa047261.19319366
56Autoimmune thyroid disease_Homo sapiens_hsa053201.17287817
57RNA polymerase_Homo sapiens_hsa030201.16211283
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.15726754
59Alzheimers disease_Homo sapiens_hsa050101.15634433
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13359707
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10641365
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10201680
63Linoleic acid metabolism_Homo sapiens_hsa005911.09551927
64Fanconi anemia pathway_Homo sapiens_hsa034601.08525782
65Hepatitis B_Homo sapiens_hsa051611.07851600
66Nucleotide excision repair_Homo sapiens_hsa034201.07412422
67HTLV-I infection_Homo sapiens_hsa051661.07103490
68Estrogen signaling pathway_Homo sapiens_hsa049151.05191755
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04137246
70Non-homologous end-joining_Homo sapiens_hsa034501.03781202
71DNA replication_Homo sapiens_hsa030301.02473480
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02253679
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01177488
74Huntingtons disease_Homo sapiens_hsa050161.01060928
75Prolactin signaling pathway_Homo sapiens_hsa049170.99984884
76Arginine and proline metabolism_Homo sapiens_hsa003300.99292937
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96395251
78Insulin signaling pathway_Homo sapiens_hsa049100.95932818
79Apoptosis_Homo sapiens_hsa042100.95301465
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93567409
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93227171
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92321276
83Phagosome_Homo sapiens_hsa041450.92215312
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91166256
85Histidine metabolism_Homo sapiens_hsa003400.91078616
86Rheumatoid arthritis_Homo sapiens_hsa053230.90586592
87Tight junction_Homo sapiens_hsa045300.89474441
88p53 signaling pathway_Homo sapiens_hsa041150.87486634
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87088926
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87063405
91Oocyte meiosis_Homo sapiens_hsa041140.85693048
92Focal adhesion_Homo sapiens_hsa045100.85152681
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84587575
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83650363
95GnRH signaling pathway_Homo sapiens_hsa049120.83640629
96RNA transport_Homo sapiens_hsa030130.83431958
97MAPK signaling pathway_Homo sapiens_hsa040100.81505232
98Choline metabolism in cancer_Homo sapiens_hsa052310.80785886
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80665730
100Fatty acid biosynthesis_Homo sapiens_hsa000610.79175652
101Melanogenesis_Homo sapiens_hsa049160.78076769
102FoxO signaling pathway_Homo sapiens_hsa040680.78036915
103Long-term depression_Homo sapiens_hsa047300.77689067
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.77125392
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76948897
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75808408
107Hedgehog signaling pathway_Homo sapiens_hsa043400.74380179
108Inositol phosphate metabolism_Homo sapiens_hsa005620.73543801
109Glutathione metabolism_Homo sapiens_hsa004800.73321297
110Notch signaling pathway_Homo sapiens_hsa043300.72881097
111Morphine addiction_Homo sapiens_hsa050320.71645485
112GABAergic synapse_Homo sapiens_hsa047270.71272851
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66689519
114Pentose phosphate pathway_Homo sapiens_hsa000300.66615282
115Pathways in cancer_Homo sapiens_hsa052000.66444847
116Taste transduction_Homo sapiens_hsa047420.66191107
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65747327
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63499919
119Epstein-Barr virus infection_Homo sapiens_hsa051690.62338207
120HIF-1 signaling pathway_Homo sapiens_hsa040660.61678395
121Hippo signaling pathway_Homo sapiens_hsa043900.60853312
122Glutamatergic synapse_Homo sapiens_hsa047240.58478492
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58406494
124Rap1 signaling pathway_Homo sapiens_hsa040150.58395009
125Other glycan degradation_Homo sapiens_hsa005110.58073349
126Synaptic vesicle cycle_Homo sapiens_hsa047210.58062878
127Type II diabetes mellitus_Homo sapiens_hsa049300.57859081
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57677796
129Ribosome_Homo sapiens_hsa030100.57629010
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57346401
131Osteoclast differentiation_Homo sapiens_hsa043800.56216442
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55437324
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55340902
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55224987
135Purine metabolism_Homo sapiens_hsa002300.54849964
136Ras signaling pathway_Homo sapiens_hsa040140.54038530
137Viral myocarditis_Homo sapiens_hsa054160.53444033
138Nicotine addiction_Homo sapiens_hsa050330.53442327
139* Metabolic pathways_Homo sapiens_hsa011000.53122271
140T cell receptor signaling pathway_Homo sapiens_hsa046600.53052884
141Influenza A_Homo sapiens_hsa051640.52689659
142Hepatitis C_Homo sapiens_hsa051600.52487567
143Allograft rejection_Homo sapiens_hsa053300.51072173
144Toxoplasmosis_Homo sapiens_hsa051450.49029191
145AMPK signaling pathway_Homo sapiens_hsa041520.48916188
146Herpes simplex infection_Homo sapiens_hsa051680.48021193
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47906463
148Wnt signaling pathway_Homo sapiens_hsa043100.47835373
149Olfactory transduction_Homo sapiens_hsa047400.47536604
150Dopaminergic synapse_Homo sapiens_hsa047280.47351627
151Basal cell carcinoma_Homo sapiens_hsa052170.46492178
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44825894
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44796391
154Propanoate metabolism_Homo sapiens_hsa006400.43624468
155Spliceosome_Homo sapiens_hsa030400.42428596
156Ovarian steroidogenesis_Homo sapiens_hsa049130.40864733
157mRNA surveillance pathway_Homo sapiens_hsa030150.40392842
158Fatty acid metabolism_Homo sapiens_hsa012120.40231898
159Steroid hormone biosynthesis_Homo sapiens_hsa001400.39902808
160Melanoma_Homo sapiens_hsa052180.38851108
161RNA degradation_Homo sapiens_hsa030180.37985016
162ErbB signaling pathway_Homo sapiens_hsa040120.36123943
163Cell cycle_Homo sapiens_hsa041100.36110466
164Sphingolipid signaling pathway_Homo sapiens_hsa040710.34048619
165Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32890700
166Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32206313
167Butanoate metabolism_Homo sapiens_hsa006500.31745808
168Gap junction_Homo sapiens_hsa045400.31567915
169Peroxisome_Homo sapiens_hsa041460.27526539
170Mineral absorption_Homo sapiens_hsa049780.26946518
171Asthma_Homo sapiens_hsa053100.26210155
172TGF-beta signaling pathway_Homo sapiens_hsa043500.25264736
173Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24853547
174Cardiac muscle contraction_Homo sapiens_hsa042600.24660209
175Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23186101
176Prostate cancer_Homo sapiens_hsa052150.22946217
177Circadian entrainment_Homo sapiens_hsa047130.22180170
178Endocytosis_Homo sapiens_hsa041440.21972643
179Graft-versus-host disease_Homo sapiens_hsa053320.19901440

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