ADORA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1N-acetylneuraminate metabolic process (GO:0006054)5.20395644
2amino sugar catabolic process (GO:0046348)5.20156796
3negative regulation of interleukin-12 production (GO:0032695)5.01553186
4microglial cell activation (GO:0001774)4.92312301
5G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.73614277
6positive regulation of chemokine secretion (GO:0090197)4.63178077
7positive regulation by symbiont of host defense response (GO:0052509)4.62750449
8modulation by symbiont of host defense response (GO:0052031)4.62750449
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.62750449
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.62750449
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.62750449
12modulation by symbiont of host immune response (GO:0052553)4.62750449
13glycosphingolipid catabolic process (GO:0046479)4.32839191
14immunoglobulin mediated immune response (GO:0016064)4.31109392
15cellular response to thyroid hormone stimulus (GO:0097067)4.29626377
16regulation of mononuclear cell migration (GO:0071675)4.26195831
17regulation of macrophage chemotaxis (GO:0010758)4.15647255
18barbed-end actin filament capping (GO:0051016)4.08123683
19negative regulation of mast cell activation (GO:0033004)3.99455390
20positive regulation of gamma-delta T cell activation (GO:0046645)3.97335771
21superoxide anion generation (GO:0042554)3.95539267
22regulation of chemokine secretion (GO:0090196)3.94081758
23ceramide catabolic process (GO:0046514)3.82906961
24glycolipid catabolic process (GO:0019377)3.82337193
25detection of external biotic stimulus (GO:0098581)3.75532954
26macrophage differentiation (GO:0030225)3.68507167
27response to peptidoglycan (GO:0032494)3.68231778
28* positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.64911711
29positive regulation of cellular amide metabolic process (GO:0034250)3.60856292
30purinergic nucleotide receptor signaling pathway (GO:0035590)3.60444014
31* regulation of leukocyte degranulation (GO:0043300)3.58212519
32positive regulation of monocyte chemotaxis (GO:0090026)3.54890300
33oligosaccharide catabolic process (GO:0009313)3.54504429
34T-helper 1 type immune response (GO:0042088)3.52777146
35neutrophil activation involved in immune response (GO:0002283)3.52244551
36regulation of B cell receptor signaling pathway (GO:0050855)3.52017778
37negative regulation of erythrocyte differentiation (GO:0045647)3.51111242
38macrophage activation involved in immune response (GO:0002281)3.50690811
39regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.49581195
40regulation of activation of Janus kinase activity (GO:0010533)3.45310782
41* regulation of mast cell activation (GO:0033003)3.44259776
42cellular response to exogenous dsRNA (GO:0071360)3.42578989
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41196728
44negative regulation of cell killing (GO:0031342)3.41196728
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.39091080
46response to host immune response (GO:0052572)3.39091080
47* regulation of mast cell activation involved in immune response (GO:0033006)3.36173191
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.35973043
49* regulation of mast cell degranulation (GO:0043304)3.35294509
50macrophage activation (GO:0042116)3.32280501
51positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.31855480
52response to thyroid hormone (GO:0097066)3.31352284
53regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.29192443
54response to acidic pH (GO:0010447)3.27249434
55detection of biotic stimulus (GO:0009595)3.26589451
56phagosome maturation (GO:0090382)3.23038422
57dendritic cell chemotaxis (GO:0002407)3.21458437
58production of molecular mediator involved in inflammatory response (GO:0002532)3.20804615
59positive regulation of antigen processing and presentation (GO:0002579)3.20267967
60mannose metabolic process (GO:0006013)3.18991956
61positive regulation of defense response to virus by host (GO:0002230)3.18873844
62negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.17784206
63interferon-gamma-mediated signaling pathway (GO:0060333)3.15775365
64respiratory burst (GO:0045730)3.10657853
65neutrophil activation (GO:0042119)3.08570250
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05673076
67lytic vacuole organization (GO:0080171)3.05310758
68lysosome organization (GO:0007040)3.05310758
69regulation of interferon-beta biosynthetic process (GO:0045357)3.05241375
70regulation of antigen processing and presentation (GO:0002577)3.04549292
71lipoxygenase pathway (GO:0019372)3.04211096
72response to muramyl dipeptide (GO:0032495)3.03512726
73response to host (GO:0075136)3.02491356
74response to host defenses (GO:0052200)3.02491356
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02491356
76B cell mediated immunity (GO:0019724)3.02244489
77nucleotide transmembrane transport (GO:1901679)3.02235452
78mast cell activation (GO:0045576)3.01433332
79positive regulation of phagocytosis (GO:0050766)2.99381431
80apoptotic cell clearance (GO:0043277)2.98545349
81dendritic cell migration (GO:0036336)2.98119756
82regulation of superoxide anion generation (GO:0032928)2.96759223
83myeloid cell activation involved in immune response (GO:0002275)2.95794384
84regulation of T-helper 2 cell differentiation (GO:0045628)2.95696971
85regulation of chemokine-mediated signaling pathway (GO:0070099)2.93386658
86positive regulation of interferon-alpha production (GO:0032727)2.91048163
87regulation of T cell tolerance induction (GO:0002664)2.89500696
88cellular response to interferon-beta (GO:0035458)2.87845964
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86947041
90virion attachment to host cell (GO:0019062)2.86719228
91adhesion of symbiont to host cell (GO:0044650)2.86719228
92pinocytosis (GO:0006907)2.84522285
93energy homeostasis (GO:0097009)2.84271250
94granulocyte activation (GO:0036230)2.84187586
95detection of other organism (GO:0098543)2.83849710
96* regulation of regulated secretory pathway (GO:1903305)2.81489380
97* positive regulation of leukocyte degranulation (GO:0043302)2.80973873
98sphingolipid catabolic process (GO:0030149)2.80283548
99positive regulation of T cell migration (GO:2000406)2.80111972
100actin filament polymerization (GO:0030041)2.79369800
101positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.78472423
102* positive regulation of mast cell degranulation (GO:0043306)2.76926696
103* positive regulation of mast cell activation involved in immune response (GO:0033008)2.76926696
104positive regulation of toll-like receptor signaling pathway (GO:0034123)2.76200022
105regulation of gamma-delta T cell activation (GO:0046643)2.75832367
106positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.75421652
107regulation of interleukin-6 biosynthetic process (GO:0045408)2.74751452
108regulation of interferon-alpha production (GO:0032647)2.74526953
109adhesion of symbiont to host (GO:0044406)2.72807939
110positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.72416289
111regulation of phagocytosis (GO:0050764)2.71383993
112positive regulation of interleukin-17 production (GO:0032740)2.69090600
113positive regulation of lymphocyte migration (GO:2000403)2.68022415
114negative regulation of phagocytosis (GO:0050765)2.66942603
115myeloid leukocyte activation (GO:0002274)2.66196183
116negative regulation of granulocyte differentiation (GO:0030853)2.66169692
117detection of molecule of bacterial origin (GO:0032490)2.63927011
118regulation of monocyte chemotaxis (GO:0090025)2.60788006
119poly(A)+ mRNA export from nucleus (GO:0016973)2.57831611
120cellular extravasation (GO:0045123)2.55887791
121positive regulation of T-helper 1 type immune response (GO:0002827)2.55728163
122* G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.54862969
123leukocyte degranulation (GO:0043299)2.52156086
124positive regulation of interleukin-1 beta secretion (GO:0050718)2.51030088
125superoxide metabolic process (GO:0006801)2.49094801
126myeloid dendritic cell activation (GO:0001773)2.48920397
127natural killer cell activation involved in immune response (GO:0002323)2.47605511
128* regulation of myeloid leukocyte mediated immunity (GO:0002886)2.47312483
129negative regulation of myoblast differentiation (GO:0045662)2.47223782
130interferon-gamma production (GO:0032609)2.46881985
131regulation of T cell migration (GO:2000404)2.45145506
132eosinophil chemotaxis (GO:0048245)2.44244762
133detection of bacterium (GO:0016045)2.43805697
134regulation of lymphocyte migration (GO:2000401)2.42478132
135* positive regulation of mast cell activation (GO:0033005)2.42364639
136regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.41577974
137* purinergic receptor signaling pathway (GO:0035587)2.41555109
138regulation of hypersensitivity (GO:0002883)2.41400509
139membrane lipid catabolic process (GO:0046466)2.37966718
140phagocytosis, engulfment (GO:0006911)2.37851007
141leukotriene metabolic process (GO:0006691)2.36946910
142GPI anchor biosynthetic process (GO:0006506)2.36839746
143cyclooxygenase pathway (GO:0019371)2.35043604
144regulation of interleukin-17 production (GO:0032660)2.33810892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.42125554
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.26455687
3* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human4.02240006
4* IRF8_22096565_ChIP-ChIP_GC-B_Human3.69490545
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.46726817
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.32238047
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26213691
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.05780162
9* SPI1_23127762_ChIP-Seq_K562_Human2.79505301
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.60692730
11GBX2_23144817_ChIP-Seq_PC3_Human2.59087078
12VDR_24763502_ChIP-Seq_THP-1_Human2.58892249
13VDR_21846776_ChIP-Seq_THP-1_Human2.47978723
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35938906
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33246522
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27326693
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23777947
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23774490
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.16274561
20* LXR_22292898_ChIP-Seq_THP-1_Human2.14398709
21SUZ12_27294783_Chip-Seq_NPCs_Mouse2.05075844
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04511263
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.03288758
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95535132
25* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91608769
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90950097
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.90642862
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84695808
29* SCL_19346495_ChIP-Seq_HPC-7_Human1.82178690
30SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80537621
31* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78757879
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78139080
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77156514
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76217233
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75941284
36SUZ12_18555785_Chip-Seq_ESCs_Mouse1.75412329
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74117685
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73116738
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.71756876
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68959692
41STAT3_18555785_Chip-Seq_ESCs_Mouse1.67849184
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.64909177
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.62606813
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60997508
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60925492
46* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59571658
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.58102568
48E2F1_18555785_Chip-Seq_ESCs_Mouse1.55626179
49EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.53405905
50* GATA1_19941827_ChIP-Seq_MEL_Mouse1.53181837
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52891309
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.52828854
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52553174
54P53_22387025_ChIP-Seq_ESCs_Mouse1.50691276
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49505032
56NMYC_18555785_Chip-Seq_ESCs_Mouse1.49206890
57* P300_18555785_Chip-Seq_ESCs_Mouse1.48829631
58ZFX_18555785_Chip-Seq_ESCs_Mouse1.46615333
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.46480490
60RUNX1_27457419_Chip-Seq_LIVER_Mouse1.44942251
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43787164
62OCT4_18555785_Chip-Seq_ESCs_Mouse1.43279805
63* SPI1_23547873_ChIP-Seq_NB4_Human1.42915305
64RUNX_20019798_ChIP-Seq_JUKART_Human1.41961891
65BCL6_27268052_Chip-Seq_Bcells_Human1.41631501
66PU1_27457419_Chip-Seq_LIVER_Mouse1.39481530
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39255812
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38490862
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36619221
70GATA1_19941826_ChIP-Seq_K562_Human1.34785788
71KDM2B_26808549_Chip-Seq_DND41_Human1.34281638
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.33436640
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32335995
74KLF4_18555785_Chip-Seq_ESCs_Mouse1.32273347
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.32066514
76BCOR_27268052_Chip-Seq_Bcells_Human1.31330823
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31130136
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31073845
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30600356
80MAF_26560356_Chip-Seq_TH1_Human1.30218030
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29962143
82ESRRB_18555785_Chip-Seq_ESCs_Mouse1.29446614
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29048445
84P300_19829295_ChIP-Seq_ESCs_Human1.28768681
85CTCF_18555785_Chip-Seq_ESCs_Mouse1.28077797
86* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28050389
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27278299
88TCF7_22412390_ChIP-Seq_EML_Mouse1.27058492
89* ELK3_25401928_ChIP-Seq_HUVEC_Human1.26712879
90* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.24656546
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22986485
92* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21727136
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21410618
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.20935422
95SPI1_20517297_ChIP-Seq_HL60_Human1.19909869
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18741431
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17947790
98E2F7_22180533_ChIP-Seq_HELA_Human1.17444690
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16007314
100GATA1_22025678_ChIP-Seq_K562_Human1.15617260
101* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13086614
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12922838
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12708733
104* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12332651
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11976012
106TFEB_21752829_ChIP-Seq_HELA_Human1.11656313
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11499261
108DROSHA_22980978_ChIP-Seq_HELA_Human1.11043558
109LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10296997
110* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10154304
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.09924109
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.08835956
113* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08659185
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08452175
115STAT1_20625510_ChIP-Seq_HELA_Human1.07182919
116UTX_26944678_Chip-Seq_JUKART_Human1.07143852
117ER_23166858_ChIP-Seq_MCF-7_Human1.06786616
118POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06152288
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.05628036
120KDM2B_26808549_Chip-Seq_K562_Human1.05161154
121* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04152214
122RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03824377
123MAF_26560356_Chip-Seq_TH2_Human1.03649562
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03443207
125IGF1R_20145208_ChIP-Seq_DFB_Human1.03140115
126GATA2_21666600_ChIP-Seq_HMVEC_Human1.01270230
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00312995
128MYC_22102868_ChIP-Seq_BL_Human1.00207798
129KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00171868
130* MYB_26560356_Chip-Seq_TH2_Human0.99853773
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98465042
132IRF1_19129219_ChIP-ChIP_H3396_Human0.98404949
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98243183
134SRF_21415370_ChIP-Seq_HL-1_Mouse0.98127867
135NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97978396
136* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97204459
137GATA2_19941826_ChIP-Seq_K562_Human0.97074414
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97031714
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96915161
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96848440
141OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96489425
142PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94309157
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94229684
144PU_27001747_Chip-Seq_BMDM_Mouse0.93751216
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93693184
146VDR_22108803_ChIP-Seq_LS180_Human0.93647362
147* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93592040
148VDR_24787735_ChIP-Seq_THP-1_Human0.92327172
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90837728
150SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90567164
151CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90430163
152KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90162077
153MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89315769
154STAT1_17558387_ChIP-Seq_HELA_Human0.89226551
155EZH2_22144423_ChIP-Seq_EOC_Human0.88811641
156EWS_26573619_Chip-Seq_HEK293_Human0.87689816
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86831139
158TAF15_26573619_Chip-Seq_HEK293_Human0.86370824
159SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86302027
160RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85995246
161P68_20966046_ChIP-Seq_HELA_Human0.85013228
162KDM2B_26808549_Chip-Seq_REH_Human0.84921229
163SA1_27219007_Chip-Seq_ERYTHROID_Human0.84454933
164SMC4_20622854_ChIP-Seq_HELA_Human0.84212452
165CTCF_20526341_ChIP-Seq_ESCs_Human0.83456248
166FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81786811
167RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80261684
168* GATA3_27048872_Chip-Seq_THYMUS_Human0.79874913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.68852395
2MP0002148_abnormal_hypersensitivity_rea3.30718689
3MP0006082_CNS_inflammation3.25472802
4MP0009840_abnormal_foam_cell3.21262807
5MP0006292_abnormal_olfactory_placode3.07214460
6MP0005671_abnormal_response_to2.98939125
7MP0003303_peritoneal_inflammation2.91587643
8MP0000604_amyloidosis2.61373883
9MP0003136_yellow_coat_color2.51568772
10MP0002419_abnormal_innate_immunity2.49417023
11MP0005409_darkened_coat_color2.38221355
12MP0003300_gastrointestinal_ulcer2.37161501
13MP0009785_altered_susceptibility_to2.37056900
14MP0000566_synostosis2.33780904
15MP0005000_abnormal_immune_tolerance2.30771594
16MP0002277_abnormal_respiratory_mucosa2.23016091
17MP0005167_abnormal_blood-brain_barrier2.18784083
18MP0005387_immune_system_phenotype2.12560155
19MP0001790_abnormal_immune_system2.12560155
20MP0002452_abnormal_antigen_presenting2.09241613
21MP0005025_abnormal_response_to2.08488923
22MP0003724_increased_susceptibility_to2.06028427
23MP0003436_decreased_susceptibility_to2.03830195
24MP0008058_abnormal_DNA_repair2.02124761
25MP0001188_hyperpigmentation2.00422652
26MP0005451_abnormal_body_composition2.00215708
27* MP0002723_abnormal_immune_serum1.98738120
28MP0005171_absent_coat_pigmentation1.96047596
29MP0004147_increased_porphyrin_level1.92877100
30MP0002132_abnormal_respiratory_system1.92601661
31MP0001800_abnormal_humoral_immune1.90891286
32MP0001986_abnormal_taste_sensitivity1.90479314
33* MP0001819_abnormal_immune_cell1.88724134
34MP0000015_abnormal_ear_pigmentation1.87088764
35* MP0002420_abnormal_adaptive_immunity1.85830630
36MP0003828_pulmonary_edema1.84976182
37MP0005464_abnormal_platelet_physiology1.80108930
38MP0005646_abnormal_pituitary_gland1.76229425
39MP0005075_abnormal_melanosome_morpholog1.73936726
40MP0005645_abnormal_hypothalamus_physiol1.68629795
41MP0003172_abnormal_lysosome_physiology1.67450407
42MP0004782_abnormal_surfactant_physiolog1.66892744
43MP0005058_abnormal_lysosome_morphology1.66800541
44MP0004510_myositis1.57347861
45MP0009278_abnormal_bone_marrow1.52845231
46MP0002405_respiratory_system_inflammati1.52512251
47MP0003329_amyloid_beta_deposits1.52062500
48MP0004381_abnormal_hair_follicle1.44396152
49MP0008007_abnormal_cellular_replicative1.43495693
50MP0005174_abnormal_tail_pigmentation1.43465597
51MP0005310_abnormal_salivary_gland1.42696121
52MP0003787_abnormal_imprinting1.42501113
53MP0002396_abnormal_hematopoietic_system1.39555457
54MP0003763_abnormal_thymus_physiology1.36413430
55MP0001545_abnormal_hematopoietic_system1.36360159
56MP0005397_hematopoietic_system_phenotyp1.36360159
57MP0008057_abnormal_DNA_replication1.36177270
58MP0000716_abnormal_immune_system1.32060740
59MP0001853_heart_inflammation1.31694330
60MP0000685_abnormal_immune_system1.28791276
61MP0002638_abnormal_pupillary_reflex1.28448914
62MP0002398_abnormal_bone_marrow1.24147303
63MP0001542_abnormal_bone_strength1.21817464
64MP0000858_altered_metastatic_potential1.21376070
65MP0003183_abnormal_peptide_metabolism1.17092162
66MP0005166_decreased_susceptibility_to1.16306607
67MP0002095_abnormal_skin_pigmentation1.13908173
68MP0002876_abnormal_thyroid_physiology1.13698611
69MP0004142_abnormal_muscle_tone1.13587403
70MP0002009_preneoplasia1.12858063
71MP0009333_abnormal_splenocyte_physiolog1.11795336
72MP0001845_abnormal_inflammatory_respons1.11364055
73MP0003634_abnormal_glial_cell1.08969894
74MP0001533_abnormal_skeleton_physiology1.08391572
75MP0000920_abnormal_myelination1.08159302
76MP0002998_abnormal_bone_remodeling1.05841729
77MP0009764_decreased_sensitivity_to1.03510710
78MP0000465_gastrointestinal_hemorrhage1.03072014
79MP0002429_abnormal_blood_cell1.02905513
80MP0000372_irregular_coat_pigmentation1.01892103
81MP0004883_abnormal_blood_vessel1.00921367
82MP0008877_abnormal_DNA_methylation0.98491000
83MP0000689_abnormal_spleen_morphology0.97229134
84MP0001873_stomach_inflammation0.96585778
85MP0000681_abnormal_thyroid_gland0.96511322
86MP0005365_abnormal_bile_salt0.96425900
87MP0008469_abnormal_protein_level0.95712833
88MP0002006_tumorigenesis0.95452037
89MP0004947_skin_inflammation0.95424560
90MP0002139_abnormal_hepatobiliary_system0.95268986
91MP0010386_abnormal_urinary_bladder0.94738926
92MP0002933_joint_inflammation0.94020569
93MP0002090_abnormal_vision0.93860864
94MP0005410_abnormal_fertilization0.93557244
95MP0003633_abnormal_nervous_system0.92544018
96MP0010155_abnormal_intestine_physiology0.91357313
97MP0008260_abnormal_autophagy0.90792119
98MP0003690_abnormal_glial_cell0.90715039
99MP0005165_increased_susceptibility_to0.90332907
100MP0009765_abnormal_xenobiotic_induced0.90025445
101MP0003879_abnormal_hair_cell0.89429526
102MP0005670_abnormal_white_adipose0.88113475
103MP0002722_abnormal_immune_system0.86816922
104MP0001851_eye_inflammation0.84762570
105MP0009697_abnormal_copulation0.84668929
106MP0003806_abnormal_nucleotide_metabolis0.84392223
107MP0000490_abnormal_crypts_of0.83647466
108MP0001663_abnormal_digestive_system0.81496986
109MP0003795_abnormal_bone_structure0.80745043
110MP0000343_altered_response_to0.80667028
111MP0005584_abnormal_enzyme/coenzyme_acti0.79887626
112MP0003632_abnormal_nervous_system0.79650644
113MP0008004_abnormal_stomach_pH0.78709256
114MP0000249_abnormal_blood_vessel0.78587961
115MP0001849_ear_inflammation0.76038919
116MP0008789_abnormal_olfactory_epithelium0.75828702
117MP0003943_abnormal_hepatobiliary_system0.75807171
118MP0003786_premature_aging0.74480108
119MP0003075_altered_response_to0.73842667
120MP0001186_pigmentation_phenotype0.73536498
121MP0002138_abnormal_hepatobiliary_system0.73135761
122MP0009763_increased_sensitivity_to0.72821155
123MP0002971_abnormal_brown_adipose0.71305887
124MP0005390_skeleton_phenotype0.71107173
125MP0003866_abnormal_defecation0.70985903
126MP0005164_abnormal_response_to0.70267270
127MP0003279_aneurysm0.70151385
128MP0005377_hearing/vestibular/ear_phenot0.69855276
129MP0003878_abnormal_ear_physiology0.69855276
130MP0000383_abnormal_hair_follicle0.69273889
131MP0003631_nervous_system_phenotype0.68693726
132MP0001984_abnormal_olfaction0.68607652
133MP0002254_reproductive_system_inflammat0.68605610
134MP0003448_altered_tumor_morphology0.68373394
135MP0003950_abnormal_plasma_membrane0.67600283
136MP0010094_abnormal_chromosome_stability0.67272042
137MP0002229_neurodegeneration0.67120814
138MP0003191_abnormal_cellular_cholesterol0.66630506
139MP0002166_altered_tumor_susceptibility0.64797223
140MP0004742_abnormal_vestibular_system0.64329734
141MP0009115_abnormal_fat_cell0.61251320
142MP0002896_abnormal_bone_mineralization0.60610784
143MP0005595_abnormal_vascular_smooth0.60162009
144MP0008874_decreased_physiological_sensi0.59271437
145MP0010307_abnormal_tumor_latency0.58439915
146MP0003011_delayed_dark_adaptation0.56474668

Predicted human phenotypes

RankGene SetZ-score
1Disinhibition (HP:0000734)5.36175554
2Dysostosis multiplex (HP:0000943)4.91658760
3Mutism (HP:0002300)4.88086719
4Recurrent abscess formation (HP:0002722)4.68001443
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.50368057
6Axonal loss (HP:0003447)4.46990847
7Spontaneous hematomas (HP:0007420)4.45389747
8Recurrent bacterial skin infections (HP:0005406)4.30491716
9Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.28771497
10Complement deficiency (HP:0004431)4.13868491
11Chromsome breakage (HP:0040012)4.03185572
12Loss of speech (HP:0002371)4.02550702
13Upper motor neuron abnormality (HP:0002127)3.94852749
14Abnormality of complement system (HP:0005339)3.77435534
15Abnormality of mucopolysaccharide metabolism (HP:0011020)3.72398137
16Abnormality of polysaccharide metabolism (HP:0011012)3.72398137
17Abnormality of glycosaminoglycan metabolism (HP:0004371)3.72398137
18Duplicated collecting system (HP:0000081)3.55340840
19Eczematoid dermatitis (HP:0000976)3.53957922
20Mucopolysacchariduria (HP:0008155)3.52476066
21Urinary glycosaminoglycan excretion (HP:0003541)3.52476066
22Abnormality of the vasculature of the conjunctiva (HP:0008054)3.43900351
23Abnormality of the renal collecting system (HP:0004742)3.40483532
24Neurofibrillary tangles (HP:0002185)3.39145768
25Methylmalonic acidemia (HP:0002912)3.26023714
26Optic neuritis (HP:0100653)3.24725491
27Retrobulbar optic neuritis (HP:0100654)3.24725491
28Retinal atrophy (HP:0001105)3.20724182
29Recurrent skin infections (HP:0001581)3.20240236
30Inappropriate behavior (HP:0000719)3.14478595
31Abnormality of liposaccharide metabolism (HP:0010968)3.12550933
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.12550933
33Abnormality of glycolipid metabolism (HP:0010969)3.12550933
34Nephritis (HP:0000123)3.08279578
35Systemic lupus erythematosus (HP:0002725)3.03978938
36Nuclear cataract (HP:0100018)2.98919142
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.97099207
38Neuronal loss in central nervous system (HP:0002529)2.90486729
39Personality changes (HP:0000751)2.90154977
40Purpura (HP:0000979)2.78401462
41Hematochezia (HP:0002573)2.76065698
42Pathologic fracture (HP:0002756)2.73987407
43Obstructive lung disease (HP:0006536)2.72721692
44Chronic obstructive pulmonary disease (HP:0006510)2.72721692
45Orchitis (HP:0100796)2.71195849
46Recurrent cutaneous fungal infections (HP:0011370)2.65897841
47Chronic mucocutaneous candidiasis (HP:0002728)2.65897841
48Amyloidosis (HP:0011034)2.65661747
49Myositis (HP:0100614)2.62786404
50Chronic otitis media (HP:0000389)2.58853271
51Hemoptysis (HP:0002105)2.53795270
52Chronic diarrhea (HP:0002028)2.50404132
53Clubbing of toes (HP:0100760)2.47987480
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47615059
55Prostate neoplasm (HP:0100787)2.47384522
56Apathy (HP:0000741)2.46635887
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.45322773
58Abnormality of macrophages (HP:0004311)2.44875043
59Type I transferrin isoform profile (HP:0003642)2.44204284
60Diminished motivation (HP:0000745)2.42672416
61True hermaphroditism (HP:0010459)2.40905383
62Petechiae (HP:0000967)2.39883027
63Dementia (HP:0000726)2.39465502
64Elevated erythrocyte sedimentation rate (HP:0003565)2.39262841
65Recurrent fungal infections (HP:0002841)2.38673333
66Abnormality of DNA repair (HP:0003254)2.37351061
67Global brain atrophy (HP:0002283)2.37123447
68Asymmetric septal hypertrophy (HP:0001670)2.35412933
69Progressive visual loss (HP:0000529)2.34831371
70Cerebral inclusion bodies (HP:0100314)2.34242815
71Recurrent gram-negative bacterial infections (HP:0005420)2.33878202
72Duplication of thumb phalanx (HP:0009942)2.32904802
73White forelock (HP:0002211)2.32770094
74Autoimmune thrombocytopenia (HP:0001973)2.30456124
75Abnormality of the vitamin B12 metabolism (HP:0004341)2.28563052
76Septo-optic dysplasia (HP:0100842)2.27709730
77Peripheral demyelination (HP:0011096)2.27423491
78Glomerulonephritis (HP:0000099)2.27271350
79Hypoplasia of the fovea (HP:0007750)2.26278500
80Aplasia/Hypoplasia of the fovea (HP:0008060)2.26278500
81Intestinal atresia (HP:0011100)2.25098777
82Pustule (HP:0200039)2.25055383
83Abnormality of vitamin B metabolism (HP:0004340)2.25034533
84Mediastinal lymphadenopathy (HP:0100721)2.24577978
85Basal ganglia calcification (HP:0002135)2.23226636
86Patchy hypopigmentation of hair (HP:0011365)2.23191123
87Meningitis (HP:0001287)2.22093752
88Progressive neurologic deterioration (HP:0002344)2.20525727
89Prolonged bleeding time (HP:0003010)2.20509315
90Recurrent pneumonia (HP:0006532)2.16171318
91Abnormality of the preputium (HP:0100587)2.15311954
92Abnormal delayed hypersensitivity skin test (HP:0002963)2.14058195
93Pancreatic fibrosis (HP:0100732)2.11390608
94Ectopic kidney (HP:0000086)2.09074652
95Reduced antithrombin III activity (HP:0001976)2.07133429
96Congenital sensorineural hearing impairment (HP:0008527)2.05802758
97Thoracic kyphosis (HP:0002942)2.04870119
98Conjunctival telangiectasia (HP:0000524)2.04594892
99Vasculitis (HP:0002633)2.04307293
100Homocystinuria (HP:0002156)2.03652443
101Abnormality of homocysteine metabolism (HP:0010919)2.03652443
102Abnormal rod and cone electroretinograms (HP:0008323)2.02348351
103Memory impairment (HP:0002354)2.02227097
104Stomatitis (HP:0010280)2.02011909
105Recurrent viral infections (HP:0004429)2.01451417
106Aplasia cutis congenita (HP:0001057)1.99562303
107Acrocyanosis (HP:0001063)1.98608638
108Abnormal hair whorl (HP:0010721)1.98500773
109Vertebral compression fractures (HP:0002953)1.96296663
110Bone marrow hypocellularity (HP:0005528)1.95870236
111Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95339914
112Gingivitis (HP:0000230)1.94428280
113Abnormality of the fovea (HP:0000493)1.94317937
114Agnosia (HP:0010524)1.93477706
115Optic nerve hypoplasia (HP:0000609)1.93447844
116Polyneuropathy (HP:0001271)1.93224963
117Abnormality of the nasal mucosa (HP:0000433)1.92019635
118Increased CSF protein (HP:0002922)1.91433336
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.91187318
120Increased serum ferritin (HP:0003281)1.90962577
121Abnormality of the prostate (HP:0008775)1.90824924
122Cardiomegaly (HP:0001640)1.90542184
123Urticaria (HP:0001025)1.90522930
124Aplastic anemia (HP:0001915)1.90049028
125Meckel diverticulum (HP:0002245)1.89676270
126Increased IgM level (HP:0003496)1.88550051
127Myocardial infarction (HP:0001658)1.88500141
128Methylmalonic aciduria (HP:0012120)1.88382366
129Hepatosplenomegaly (HP:0001433)1.88353818
130Epistaxis (HP:0000421)1.88013779
131Bone pain (HP:0002653)1.87985828
132Neutropenia (HP:0001875)1.87894236
133Restrictive lung disease (HP:0002091)1.87730422
134Urethral obstruction (HP:0000796)1.85126609
135Abnormality of the ileum (HP:0001549)1.84917618
136Cellulitis (HP:0100658)1.84073822
137Renal cortical cysts (HP:0000803)1.84028560
138Abnormal glycosylation (HP:0012345)1.83847077
139Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83847077
140Abnormal protein N-linked glycosylation (HP:0012347)1.83847077
141Abnormal protein glycosylation (HP:0012346)1.83847077
142Abnormality of the periventricular white matter (HP:0002518)1.82901470
143Abnormality of incisor morphology (HP:0011063)1.82640507
144Supranuclear gaze palsy (HP:0000605)1.82254961
145Bone cyst (HP:0012062)1.81804877
146Increased cerebral lipofuscin (HP:0011813)1.80759044
147Vacuolated lymphocytes (HP:0001922)1.80312471
148Pulmonary infiltrates (HP:0002113)1.79710062
149Encephalitis (HP:0002383)1.78501876
150Stomach cancer (HP:0012126)1.77334372
151Type 2 muscle fiber atrophy (HP:0003554)1.77100619
152Abnormality of chromosome stability (HP:0003220)1.76538788
153Xerostomia (HP:0000217)1.76495936
154Leukopenia (HP:0001882)1.76458272
155IgM deficiency (HP:0002850)1.76049290
156Prolonged neonatal jaundice (HP:0006579)1.75277469
157Keratoconjunctivitis sicca (HP:0001097)1.74979310
158Spondylolisthesis (HP:0003302)1.72930644
159Pulmonary embolism (HP:0002204)1.72778610
160Panhypogammaglobulinemia (HP:0003139)1.71574016
161Cheilitis (HP:0100825)1.70751908
162Diplopia (HP:0000651)1.70045625
163Abnormality of binocular vision (HP:0011514)1.70045625
164Renal Fanconi syndrome (HP:0001994)1.69354230
165Urinary incontinence (HP:0000020)1.68356948
166Premature loss of primary teeth (HP:0006323)1.65789022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.62486363
2IRAK43.45734059
3CAMK1D3.03595008
4TXK2.97243279
5MAP3K142.91792413
6ERN12.65826038
7TNIK2.40795914
8ZAK2.40727022
9STK42.32794126
10BMPR1B2.22853917
11GRK72.19703453
12STK162.16488425
13CAMK1G2.09582306
14MAP3K132.07340773
15TGFBR21.99597791
16MKNK21.93102121
17CAMKK11.91577976
18FGR1.87830432
19CASK1.86273745
20BMPR21.86198775
21EIF2AK21.82748014
22TGFBR11.81635479
23TRPM71.80628280
24MAP3K111.76142290
25CLK11.73630579
26STK31.71684470
27BLK1.70132565
28VRK11.69345848
29KIT1.62950987
30IKBKB1.62546463
31NEK61.61535142
32TNK21.53382500
33SRPK11.51159361
34TEC1.49081272
35MAPK151.47660896
36FES1.47391801
37SIK31.45555913
38MAP4K11.43140561
39IKBKE1.42865420
40MKNK11.38745721
41ADRBK21.37947485
42TESK11.37717031
43ERBB31.33186588
44NME21.33134856
45TYK21.32235682
46DDR21.31988800
47MAP2K31.30792796
48PRPF4B1.27107180
49TESK21.22329358
50EIF2AK31.19527182
51YES11.18799590
52CSF1R1.18318136
53DAPK21.14604692
54CDK31.13410078
55ABL21.10163226
56RIPK41.08910374
57EPHB11.04395018
58PDPK11.04322747
59MAP3K31.03283416
60GRK11.02834270
61LYN1.01574370
62CDC42BPA0.99458500
63JAK20.97986451
64TSSK60.97469235
65TBK10.97412211
66PBK0.96410392
67ACVR1B0.94940283
68PIK3CG0.93195641
69PDK10.91860492
70CHUK0.88935616
71CDK80.87726877
72MAP3K10.87349989
73BTK0.87246217
74NUAK10.85423359
75MOS0.85092930
76SIK20.85009771
77CDK60.84869149
78RIPK10.84375738
79INSRR0.83545860
80PKN10.83091975
81SYK0.82922342
82BRD40.82746093
83TAOK10.80372644
84CSK0.80073774
85SGK20.79841480
86ITK0.76851056
87MARK20.76607278
88JAK30.74578656
89PLK40.72748100
90CAMK40.72461537
91MAPK130.72374102
92MST40.71575517
93KSR20.70671178
94IRAK20.69756185
95STK240.69493685
96IRAK10.67883917
97LCK0.66889477
98HCK0.65073007
99TAOK20.63560840
100JAK10.63347454
101MAPK70.62968156
102MARK30.62560507
103PRKD20.61425684
104PRKG20.60939758
105BCR0.59714476
106EPHB20.57690322
107RPS6KA20.55001803
108MAP2K70.54935929
109TLK10.54109563
110EIF2AK10.54040351
111PIM20.53991092
112CDK190.53799128
113PIM10.53185643
114PRKCE0.52231824
115MAPKAPK50.51567113
116PRKCQ0.51268054
117MATK0.50941414
118RPS6KA50.50041202
119ATR0.49285953
120CAMK10.48369280
121PAK40.48311129
122SGK30.47732019
123MAP3K20.47406063
124TRIB30.47103837
125RPS6KL10.46805214
126RPS6KC10.46805214
127TAOK30.45089794
128SGK4940.44281340
129SGK2230.44281340
130MAPK120.42573439
131RPS6KA60.42546614
132MAPKAPK20.42485489
133FYN0.42116299
134TIE10.41810231
135PRKCD0.41656578
136NLK0.41418100
137ARAF0.40830196
138PINK10.39126785
139ZAP700.39098544
140AKT30.37504811
141EPHA30.36213154
142ABL10.36056343
143NEK90.35850314
144CDK40.34323913
145PRKAA20.32249403
146MAP2K40.30459301
147PDK20.29263785
148CAMKK20.28997786
149MAP2K60.27927231
150PRKD10.27651160
151DYRK1B0.27404601
152IGF1R0.26203757
153KSR10.24801731
154RET0.24689639

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.66845526
2Other glycan degradation_Homo sapiens_hsa005112.50168494
3Graft-versus-host disease_Homo sapiens_hsa053322.49074060
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.48195975
5Asthma_Homo sapiens_hsa053102.35390719
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.20987129
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12130314
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.05193637
9Allograft rejection_Homo sapiens_hsa053301.99111682
10Leishmaniasis_Homo sapiens_hsa051401.96750889
11Fanconi anemia pathway_Homo sapiens_hsa034601.89333510
12Non-homologous end-joining_Homo sapiens_hsa034501.79873515
13Measles_Homo sapiens_hsa051621.77292260
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72777165
15Rheumatoid arthritis_Homo sapiens_hsa053231.72162089
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.70998741
17Hematopoietic cell lineage_Homo sapiens_hsa046401.69486170
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66373183
19Autoimmune thyroid disease_Homo sapiens_hsa053201.65187538
20Staphylococcus aureus infection_Homo sapiens_hsa051501.65116083
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62949224
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.54984206
23Protein export_Homo sapiens_hsa030601.52321647
24Viral myocarditis_Homo sapiens_hsa054161.52220346
25Lysosome_Homo sapiens_hsa041421.48217313
26Primary immunodeficiency_Homo sapiens_hsa053401.47281230
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46125289
28Arachidonic acid metabolism_Homo sapiens_hsa005901.44944372
29Complement and coagulation cascades_Homo sapiens_hsa046101.43691536
30Pertussis_Homo sapiens_hsa051331.39127157
31Homologous recombination_Homo sapiens_hsa034401.38417257
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33516807
33Osteoclast differentiation_Homo sapiens_hsa043801.33025374
34RNA polymerase_Homo sapiens_hsa030201.28783697
35Sphingolipid metabolism_Homo sapiens_hsa006001.28355790
36Malaria_Homo sapiens_hsa051441.27429054
37Herpes simplex infection_Homo sapiens_hsa051681.22012047
38Ether lipid metabolism_Homo sapiens_hsa005651.20745629
39Tuberculosis_Homo sapiens_hsa051521.19724948
40Legionellosis_Homo sapiens_hsa051341.18394825
41Influenza A_Homo sapiens_hsa051641.16180760
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14874280
43Phagosome_Homo sapiens_hsa041451.12777109
44Renin-angiotensin system_Homo sapiens_hsa046141.12513129
45Base excision repair_Homo sapiens_hsa034101.10623968
46* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08978965
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07384496
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07091044
49Basal transcription factors_Homo sapiens_hsa030221.07020559
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06190046
51Type I diabetes mellitus_Homo sapiens_hsa049401.02355985
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02204395
53Fatty acid elongation_Homo sapiens_hsa000621.00800244
54Antigen processing and presentation_Homo sapiens_hsa046120.99262924
55Chemokine signaling pathway_Homo sapiens_hsa040620.89430017
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.86818496
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86766490
58African trypanosomiasis_Homo sapiens_hsa051430.85593336
59TNF signaling pathway_Homo sapiens_hsa046680.84197107
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83973170
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81390780
62B cell receptor signaling pathway_Homo sapiens_hsa046620.79742351
63Mineral absorption_Homo sapiens_hsa049780.79718418
64Platelet activation_Homo sapiens_hsa046110.79438116
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78319581
66Pyrimidine metabolism_Homo sapiens_hsa002400.78177447
67Toxoplasmosis_Homo sapiens_hsa051450.77705686
68DNA replication_Homo sapiens_hsa030300.76954157
69Synaptic vesicle cycle_Homo sapiens_hsa047210.76166470
70Endocytosis_Homo sapiens_hsa041440.74361404
71Vibrio cholerae infection_Homo sapiens_hsa051100.73527205
72Vitamin digestion and absorption_Homo sapiens_hsa049770.72275538
73Salmonella infection_Homo sapiens_hsa051320.71956701
74Acute myeloid leukemia_Homo sapiens_hsa052210.71863637
75Apoptosis_Homo sapiens_hsa042100.67719930
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67687539
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65157140
78Mismatch repair_Homo sapiens_hsa034300.63565147
79Shigellosis_Homo sapiens_hsa051310.62392520
80Hepatitis B_Homo sapiens_hsa051610.60362948
81Collecting duct acid secretion_Homo sapiens_hsa049660.58793775
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58482051
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.56569921
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56556326
85Amoebiasis_Homo sapiens_hsa051460.56398706
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55613015
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54557318
88Hepatitis C_Homo sapiens_hsa051600.53841886
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52920679
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.51860184
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51688980
92Serotonergic synapse_Homo sapiens_hsa047260.49926180
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49634865
94ABC transporters_Homo sapiens_hsa020100.49498677
95Steroid biosynthesis_Homo sapiens_hsa001000.49177291
96Linoleic acid metabolism_Homo sapiens_hsa005910.49072613
97Prion diseases_Homo sapiens_hsa050200.48066245
98Galactose metabolism_Homo sapiens_hsa000520.47886928
99Purine metabolism_Homo sapiens_hsa002300.47779324
100Epstein-Barr virus infection_Homo sapiens_hsa051690.46742295
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45921240
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42867636
103RNA degradation_Homo sapiens_hsa030180.42101674
104GnRH signaling pathway_Homo sapiens_hsa049120.41965488
105Estrogen signaling pathway_Homo sapiens_hsa049150.40264765
106Regulation of autophagy_Homo sapiens_hsa041400.39848762
107PPAR signaling pathway_Homo sapiens_hsa033200.39103512
108VEGF signaling pathway_Homo sapiens_hsa043700.38931117
109Nucleotide excision repair_Homo sapiens_hsa034200.38850695
110Spliceosome_Homo sapiens_hsa030400.38835346
111T cell receptor signaling pathway_Homo sapiens_hsa046600.37915439
112Proteasome_Homo sapiens_hsa030500.36863037
113Nicotine addiction_Homo sapiens_hsa050330.36077369
114Renin secretion_Homo sapiens_hsa049240.34454794
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33817165
116HIF-1 signaling pathway_Homo sapiens_hsa040660.33665722
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33642918
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.33531651
119Morphine addiction_Homo sapiens_hsa050320.31987330
120Systemic lupus erythematosus_Homo sapiens_hsa053220.31272779
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31249384
122Bladder cancer_Homo sapiens_hsa052190.30815262
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30597279
124Renal cell carcinoma_Homo sapiens_hsa052110.30489252
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.30054903
126Phototransduction_Homo sapiens_hsa047440.29905746
127Histidine metabolism_Homo sapiens_hsa003400.28926185
128Prolactin signaling pathway_Homo sapiens_hsa049170.27887064
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26598332
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26323122
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24829223
132Notch signaling pathway_Homo sapiens_hsa043300.24474130
133Olfactory transduction_Homo sapiens_hsa047400.24452201
134* Sphingolipid signaling pathway_Homo sapiens_hsa040710.24364553
135Non-small cell lung cancer_Homo sapiens_hsa052230.22784134
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.22477623
137Pancreatic cancer_Homo sapiens_hsa052120.19598966
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19356886
139Rap1 signaling pathway_Homo sapiens_hsa040150.18401235
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17790906

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