ADPRH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.01861248
2immunoglobulin mediated immune response (GO:0016064)4.55672789
3response to peptidoglycan (GO:0032494)4.50933845
4negative regulation of interleukin-12 production (GO:0032695)4.43439151
5positive regulation by symbiont of host defense response (GO:0052509)4.35712709
6modulation by symbiont of host defense response (GO:0052031)4.35712709
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.35712709
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.35712709
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.35712709
10modulation by symbiont of host immune response (GO:0052553)4.35712709
11type I interferon signaling pathway (GO:0060337)4.24326931
12cellular response to type I interferon (GO:0071357)4.24326931
13response to type I interferon (GO:0034340)4.19175954
14macrophage activation involved in immune response (GO:0002281)4.10279188
15interferon-gamma-mediated signaling pathway (GO:0060333)4.01686912
16negative regulation of microtubule polymerization (GO:0031115)3.96822824
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.96048008
18regulation of T-helper 1 cell differentiation (GO:0045625)3.85416895
19negative regulation of cell killing (GO:0031342)3.83838160
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.83838160
21antigen processing and presentation of endogenous antigen (GO:0019883)3.82967560
22detection of other organism (GO:0098543)3.80133037
23neutrophil activation involved in immune response (GO:0002283)3.79825782
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.76900243
25regulation of interferon-alpha production (GO:0032647)3.75231162
26T-helper 1 type immune response (GO:0042088)3.74144346
27regulation of interferon-beta biosynthetic process (GO:0045357)3.66932235
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65281273
29regulation of dendritic cell antigen processing and presentation (GO:0002604)3.64575923
30detection of bacterium (GO:0016045)3.62286799
31B cell mediated immunity (GO:0019724)3.61976301
32lipopolysaccharide-mediated signaling pathway (GO:0031663)3.61818427
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59752358
34histone arginine methylation (GO:0034969)3.59398052
35cullin deneddylation (GO:0010388)3.58264461
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.57704346
37NIK/NF-kappaB signaling (GO:0038061)3.57044635
38regulation of gamma-delta T cell activation (GO:0046643)3.55754703
39positive regulation of interferon-alpha production (GO:0032727)3.52358104
40protein deneddylation (GO:0000338)3.51064894
41regulation of B cell receptor signaling pathway (GO:0050855)3.49920516
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.47259453
43germinal center formation (GO:0002467)3.45342178
44T cell migration (GO:0072678)3.42312448
45peptidyl-arginine omega-N-methylation (GO:0035247)3.42286384
46regulation of antigen processing and presentation (GO:0002577)3.41471477
47defense response to protozoan (GO:0042832)3.41031410
48myeloid dendritic cell differentiation (GO:0043011)3.40254714
49DNA unwinding involved in DNA replication (GO:0006268)3.37078116
50regulation of vitamin D biosynthetic process (GO:0060556)3.36427151
51positive regulation of type 2 immune response (GO:0002830)3.35817329
52detection of molecule of bacterial origin (GO:0032490)3.35210686
53mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32483512
54response to protozoan (GO:0001562)3.31801055
55myeloid dendritic cell activation (GO:0001773)3.29344004
56response to muramyl dipeptide (GO:0032495)3.29172230
57formation of translation preinitiation complex (GO:0001731)3.29144691
58detection of external biotic stimulus (GO:0098581)3.28673188
59positive regulation of antigen processing and presentation (GO:0002579)3.27818124
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24936544
61negative regulation of ligase activity (GO:0051352)3.24936544
62energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20069175
63ATP synthesis coupled proton transport (GO:0015986)3.20069175
64regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.18432413
65anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17954151
66establishment of integrated proviral latency (GO:0075713)3.17757660
67response to host immune response (GO:0052572)3.15898378
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.15898378
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15712070
70cellular response to interferon-gamma (GO:0071346)3.12534927
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12224592
72B cell receptor signaling pathway (GO:0050853)3.11429117
73establishment of protein localization to mitochondrial membrane (GO:0090151)3.10267452
74DNA strand elongation involved in DNA replication (GO:0006271)3.10238588
75negative regulation of cytokine production involved in immune response (GO:0002719)3.10156145
76proteasome assembly (GO:0043248)3.07628015
77positive regulation of B cell differentiation (GO:0045579)3.05087086
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03618564
79regulation of interleukin-12 production (GO:0032655)2.99100300
80viral transcription (GO:0019083)2.98581998
81positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97875549
82regulation of type I interferon-mediated signaling pathway (GO:0060338)2.96397187
83de novo posttranslational protein folding (GO:0051084)2.95535654
84regulation of interleukin-2 biosynthetic process (GO:0045076)2.95238131
85de novo protein folding (GO:0006458)2.94785524
86pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93644670
87myeloid cell activation involved in immune response (GO:0002275)2.92396918
88detection of biotic stimulus (GO:0009595)2.90835016
89DNA strand elongation (GO:0022616)2.89044032
90response to host (GO:0075136)2.88279371
91response to host defenses (GO:0052200)2.88279371
92response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88279371
93response to interferon-gamma (GO:0034341)2.87570061
94regulation of T-helper 2 cell differentiation (GO:0045628)2.86426784
95translational termination (GO:0006415)2.85547077
96cellular extravasation (GO:0045123)2.85400558
97regulation of T cell tolerance induction (GO:0002664)2.84445165
98positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.84425145
99negative regulation of erythrocyte differentiation (GO:0045647)2.84329924
100regulation of cytokine secretion involved in immune response (GO:0002739)2.83934003
101chaperone-mediated protein transport (GO:0072321)2.82906075
102peptidyl-arginine methylation (GO:0018216)2.82656871
103peptidyl-arginine N-methylation (GO:0035246)2.82656871
104granulocyte activation (GO:0036230)2.82226582
105regulation of type 2 immune response (GO:0002828)2.82181251
106negative regulation of myeloid cell apoptotic process (GO:0033033)2.80873966
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80408550
108JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.80345753
109DNA replication initiation (GO:0006270)2.80297915
110CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.80212704
111regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.78638506
112establishment of viral latency (GO:0019043)2.78632389
113positive regulation of cellular amide metabolic process (GO:0034250)2.78519297
114regulation of protein heterodimerization activity (GO:0043497)2.78213063
115positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76473458
116macrophage activation (GO:0042116)2.76329933
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76089297
118dendritic cell differentiation (GO:0097028)2.75490042
119signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72915621
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72915621
121spliceosomal snRNP assembly (GO:0000387)2.72882955
122positive regulation of interferon-beta production (GO:0032728)2.72429729
123positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.72404519
124regulation of podosome assembly (GO:0071801)2.71413768
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71396833
126microglial cell activation (GO:0001774)2.71172447
127positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.71013984
128positive regulation of interleukin-10 production (GO:0032733)2.70392001
129negative regulation of T cell mediated immunity (GO:0002710)2.70345705
130negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.68826862
131telomere maintenance via semi-conservative replication (GO:0032201)2.67911121
132signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67322739
133signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67322739
134signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67322739
135signal transduction involved in DNA damage checkpoint (GO:0072422)2.66975953
136signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66975953
137translational elongation (GO:0006414)2.66880707
138positive regulation of chemokine biosynthetic process (GO:0045080)2.66492817
139positive regulation of immunoglobulin mediated immune response (GO:0002891)2.66089828
140positive regulation of B cell mediated immunity (GO:0002714)2.66089828
141cellular response to thyroid hormone stimulus (GO:0097067)2.65154843
142ribosomal small subunit biogenesis (GO:0042274)2.64997400
143positive regulation of ligase activity (GO:0051351)2.64536964
144regulation of T-helper cell differentiation (GO:0045622)2.63674335
145sequestering of actin monomers (GO:0042989)2.63642343
146regulation of vitamin metabolic process (GO:0030656)2.63607308
147regulation of gamma-delta T cell differentiation (GO:0045586)2.63578230
148signal transduction involved in cell cycle checkpoint (GO:0072395)2.63227484
149translational initiation (GO:0006413)2.62616219
150protein neddylation (GO:0045116)2.59353990
151regulation of ubiquitin-protein transferase activity (GO:0051438)2.57725913
152mitotic sister chromatid segregation (GO:0000070)2.55785302
153viral mRNA export from host cell nucleus (GO:0046784)2.55641410
154tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52954403
155RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52954403
156cellular protein complex disassembly (GO:0043624)2.51850713
157regulation of ligase activity (GO:0051340)2.48783526
158cotranslational protein targeting to membrane (GO:0006613)2.48257044
159SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.45042824
160antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.44793132
161nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.42411832
162viral life cycle (GO:0019058)2.41826531
163protein targeting to ER (GO:0045047)2.41232742
164deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.41157940
165establishment of protein localization to mitochondrion (GO:0072655)2.39066106
166regulation of cellular amino acid metabolic process (GO:0006521)2.38350742
167protein complex disassembly (GO:0043241)2.38043346
168nucleotide-excision repair, DNA gap filling (GO:0006297)2.36695072
169synaptic vesicle exocytosis (GO:0016079)2.35101574
170pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.34882541
1717-methylguanosine mRNA capping (GO:0006370)2.34678297
172mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.32834471
173somatic hypermutation of immunoglobulin genes (GO:0016446)2.32737708
174somatic diversification of immune receptors via somatic mutation (GO:0002566)2.32737708
175maturation of SSU-rRNA (GO:0030490)2.32128682
176barbed-end actin filament capping (GO:0051016)2.31834946
177translation (GO:0006412)2.30168906
178base-excision repair, AP site formation (GO:0006285)2.29156667
1797-methylguanosine RNA capping (GO:0009452)2.29145100
180RNA capping (GO:0036260)2.29145100
181mitotic spindle assembly checkpoint (GO:0007094)2.28417926
182macromolecular complex disassembly (GO:0032984)2.27912907
183establishment of protein localization to endoplasmic reticulum (GO:0072599)2.27904703
184transcription-coupled nucleotide-excision repair (GO:0006283)2.27823128
185spliceosomal complex assembly (GO:0000245)2.27730813
186negative regulation of chromosome segregation (GO:0051985)2.27144303
187positive regulation of cell cycle arrest (GO:0071158)2.27008135
188protein localization to endoplasmic reticulum (GO:0070972)2.26765337
189negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.26745431
190ribosomal small subunit assembly (GO:0000028)2.25301186
191antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.25001456
192DNA replication checkpoint (GO:0000076)2.23627858
193protein insertion into membrane (GO:0051205)2.22957624
194negative regulation of protein ubiquitination (GO:0031397)2.22168337
195DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.21346298
196negative regulation of mitotic sister chromatid separation (GO:2000816)2.21092659
197negative regulation of mitotic sister chromatid segregation (GO:0033048)2.21092659
198negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.21092659
199negative regulation of sister chromatid segregation (GO:0033046)2.21092659
200protein targeting to mitochondrion (GO:0006626)2.20844910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.30232581
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.04504547
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.55909275
4E2F7_22180533_ChIP-Seq_HELA_Human4.37081949
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70863902
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.70766732
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.51980296
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.50166079
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.48502973
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.33649755
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.33499778
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.32032782
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.31688009
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24112472
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14839621
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.09850092
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05134738
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.99802099
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.97266932
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.93442082
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.87775568
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87260037
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76134875
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74591935
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.74145368
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.68538412
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62804460
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.60798824
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59572108
30* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57824859
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54313920
32XRN2_22483619_ChIP-Seq_HELA_Human2.47018763
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.44904266
34MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39846127
35CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38420967
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37604189
37VDR_24763502_ChIP-Seq_THP-1_Human2.31263301
38SPI1_23547873_ChIP-Seq_NB4_Human2.15394710
39E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15292789
40BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13754372
41FOXM1_23109430_ChIP-Seq_U2OS_Human2.12026473
42YY1_21170310_ChIP-Seq_MESCs_Mouse2.09159964
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07698487
44MAF_26560356_Chip-Seq_TH1_Human2.05382755
45SPI1_23127762_ChIP-Seq_K562_Human2.05296577
46SCL_19346495_ChIP-Seq_HPC-7_Human2.02797543
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02489386
48RUNX_20019798_ChIP-Seq_JUKART_Human1.96000693
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.95719572
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95002924
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94810016
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94543525
53* MYB_26560356_Chip-Seq_TH2_Human1.86996713
54TTF2_22483619_ChIP-Seq_HELA_Human1.86909546
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86864916
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85568985
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83538264
58VDR_23849224_ChIP-Seq_CD4+_Human1.82183027
59VDR_24787735_ChIP-Seq_THP-1_Human1.81296373
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79646135
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79497503
62GATA1_22025678_ChIP-Seq_K562_Human1.79069319
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.78637604
64GABP_19822575_ChIP-Seq_HepG2_Human1.78337370
65* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77002845
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76999476
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76344394
68DCP1A_22483619_ChIP-Seq_HELA_Human1.75813250
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74593563
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71877346
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70770587
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.69396611
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67660612
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67577414
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66836823
76CIITA_25753668_ChIP-Seq_RAJI_Human1.61724089
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61006619
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60185282
79MYB_26560356_Chip-Seq_TH1_Human1.58761130
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58210087
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57373615
82FOXP3_21729870_ChIP-Seq_TREG_Human1.57244247
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52950965
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51774800
85UTX_26944678_Chip-Seq_JUKART_Human1.51392519
86TCF7_22412390_ChIP-Seq_EML_Mouse1.51319946
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51177941
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49602032
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.49554382
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45724105
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.45470197
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45211539
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44603489
94* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44479950
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.43582188
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41756241
97* PU_27001747_Chip-Seq_BMDM_Mouse1.38845509
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38318647
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37234971
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.36993794
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36989087
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36769671
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35443671
104* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35314812
105* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34969510
106MAF_26560356_Chip-Seq_TH2_Human1.34850679
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33091989
108KDM2B_26808549_Chip-Seq_DND41_Human1.32795821
109LXR_22292898_ChIP-Seq_THP-1_Human1.32038152
110GATA1_19941827_ChIP-Seq_MEL_Mouse1.31971913
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30634432
112MYC_22102868_ChIP-Seq_BL_Human1.30172287
113SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27665090
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27001983
115KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27001983
116KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27001983
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26502761
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25766025
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24291399
120GATA2_21666600_ChIP-Seq_HMVEC_Human1.23690941
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23672616
122SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23218926
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22947280
124GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21784635
125GATA3_27048872_Chip-Seq_THYMUS_Human1.20575238
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18798004
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18794864
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18766145
129SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18002162
130TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16675888
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16412256
132GATA1_19941826_ChIP-Seq_K562_Human1.16102641
133PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15549897
134* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15519423
135CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14564862
136VDR_21846776_ChIP-Seq_THP-1_Human1.14302174
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13881011
138SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13340718
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12813687
140GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12714572
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12252157
142CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12241493
143SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12166783
144CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10690387
145PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10636607
146PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07476493
147SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07392147
148CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06898832
149FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06818429
150YY1_22570637_ChIP-Seq_MALME-3M_Human1.06660939
151KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05560107
152DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05317646
153NANOG_21062744_ChIP-ChIP_HESCs_Human1.04895521
154MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04406239
155NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04033795
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03490337
157ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03098274
158NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01192342
159EGR1_19374776_ChIP-ChIP_THP-1_Human1.01044823
160ELK1_22589737_ChIP-Seq_MCF10A_Human1.00728572
161TFEB_21752829_ChIP-Seq_HELA_Human0.98799590
162TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97772083
163ELK1_19687146_ChIP-ChIP_HELA_Human0.97625094
164HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96868579
165* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96019845
166SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95511929
167PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95477106
168SOX2_16153702_ChIP-ChIP_HESCs_Human0.95369335
169EZH2_22144423_ChIP-Seq_EOC_Human0.94008582
170GATA3_26560356_Chip-Seq_TH2_Human0.93740059
171TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93146704
172CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92527095
173SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92223559
174ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92205167
175BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91889559
176CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91670417
177KDM5A_27292631_Chip-Seq_BREAST_Human0.91344090
178SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91139380
179CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89255242
180GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88793230
181RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88219429
182IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85695557
183NCOR1_26117541_ChIP-Seq_K562_Human0.83148830
184GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82429979
185GATA2_19941826_ChIP-Seq_K562_Human0.81764098
186FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80303967
187STAT1_20625510_ChIP-Seq_HELA_Human0.80293182
188BCL6_27268052_Chip-Seq_Bcells_Human0.78031840
189KDM2B_26808549_Chip-Seq_JURKAT_Human0.77999388
190RACK7_27058665_Chip-Seq_MCF-7_Human0.77517425
191BCOR_27268052_Chip-Seq_Bcells_Human0.77260251
192ESR2_21235772_ChIP-Seq_MCF-7_Human0.75808610
193RXR_22158963_ChIP-Seq_LIVER_Mouse0.75150153

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.85690710
2MP0003724_increased_susceptibility_to3.73566241
3MP0001835_abnormal_antigen_presentation3.70868417
4MP0003436_decreased_susceptibility_to3.34627861
5MP0003880_abnormal_central_pattern3.33516480
6MP0005671_abnormal_response_to3.09111773
7MP0009785_altered_susceptibility_to3.07249494
8MP0001790_abnormal_immune_system3.04744310
9MP0005387_immune_system_phenotype3.04744310
10MP0005000_abnormal_immune_tolerance2.99028012
11MP0002148_abnormal_hypersensitivity_rea2.97141374
12MP0006082_CNS_inflammation2.82387275
13MP0000685_abnormal_immune_system2.72840567
14MP0003122_maternal_imprinting2.68352976
15MP0002419_abnormal_innate_immunity2.66613336
16MP0001800_abnormal_humoral_immune2.66393498
17MP0003300_gastrointestinal_ulcer2.59637569
18* MP0005025_abnormal_response_to2.57635126
19MP0002452_abnormal_antigen_presenting2.49639761
20MP0002723_abnormal_immune_serum2.40834029
21MP0004510_myositis2.40098371
22MP0005058_abnormal_lysosome_morphology2.39739939
23MP0001529_abnormal_vocalization2.39307364
24MP0008057_abnormal_DNA_replication2.22530282
25MP0005423_abnormal_somatic_nervous2.15863793
26MP0002420_abnormal_adaptive_immunity2.14609237
27MP0004859_abnormal_synaptic_plasticity2.13865179
28MP0004957_abnormal_blastocyst_morpholog2.13683434
29MP0001819_abnormal_immune_cell2.13050226
30MP0003693_abnormal_embryo_hatching2.10499706
31MP0005464_abnormal_platelet_physiology1.97734859
32MP0008932_abnormal_embryonic_tissue1.97609274
33MP0001533_abnormal_skeleton_physiology1.97575480
34MP0003123_paternal_imprinting1.96095525
35MP0004947_skin_inflammation1.94746445
36MP0005451_abnormal_body_composition1.93980668
37MP0003077_abnormal_cell_cycle1.93376068
38MP0010094_abnormal_chromosome_stability1.92799849
39MP0009278_abnormal_bone_marrow1.92006050
40MP0003111_abnormal_nucleus_morphology1.87401529
41MP0004133_heterotaxia1.84358533
42MP0002653_abnormal_ependyma_morphology1.82603859
43MP0006276_abnormal_autonomic_nervous1.82554526
44MP0001845_abnormal_inflammatory_respons1.80402549
45MP0001853_heart_inflammation1.80374747
46MP0010030_abnormal_orbit_morphology1.80157657
47MP0003075_altered_response_to1.78891060
48MP0010155_abnormal_intestine_physiology1.77106003
49MP0000343_altered_response_to1.74476752
50MP0002405_respiratory_system_inflammati1.73901710
51MP0003191_abnormal_cellular_cholesterol1.69681747
52MP0003121_genomic_imprinting1.67067959
53MP0008004_abnormal_stomach_pH1.66530678
54MP0009840_abnormal_foam_cell1.66395986
55MP0009764_decreased_sensitivity_to1.65217421
56MP0000716_abnormal_immune_system1.60352097
57MP0003635_abnormal_synaptic_transmissio1.59130242
58MP0004858_abnormal_nervous_system1.56431189
59MP0002998_abnormal_bone_remodeling1.55802086
60MP0001968_abnormal_touch/_nociception1.54784315
61MP0005397_hematopoietic_system_phenotyp1.54371706
62MP0001545_abnormal_hematopoietic_system1.54371706
63MP0002398_abnormal_bone_marrow1.53786023
64MP0008469_abnormal_protein_level1.52364023
65MP0004270_analgesia1.50861847
66MP0003763_abnormal_thymus_physiology1.47149460
67MP0005310_abnormal_salivary_gland1.46926045
68MP0008058_abnormal_DNA_repair1.46241093
69MP0000604_amyloidosis1.45549473
70MP0001905_abnormal_dopamine_level1.41397074
71MP0003448_altered_tumor_morphology1.33029951
72MP0000858_altered_metastatic_potential1.32843136
73MP0002735_abnormal_chemical_nociception1.32241708
74MP0000689_abnormal_spleen_morphology1.32002197
75MP0002064_seizures1.31878528
76MP0001730_embryonic_growth_arrest1.30513621
77MP0003690_abnormal_glial_cell1.30400654
78MP0002736_abnormal_nociception_after1.29927676
79MP0002751_abnormal_autonomic_nervous1.28873192
80MP0000350_abnormal_cell_proliferation1.28298378
81MP0005166_decreased_susceptibility_to1.27989092
82MP0002138_abnormal_hepatobiliary_system1.27511685
83MP0003828_pulmonary_edema1.27146560
84MP0002429_abnormal_blood_cell1.27097467
85MP0002063_abnormal_learning/memory/cond1.26463196
86MP0006072_abnormal_retinal_apoptosis1.26278674
87MP0002734_abnormal_mechanical_nocicepti1.26103682
88MP0001970_abnormal_pain_threshold1.22679534
89MP0002733_abnormal_thermal_nociception1.21952164
90MP0000778_abnormal_nervous_system1.21827821
91MP0000955_abnormal_spinal_cord1.20931468
92MP0002722_abnormal_immune_system1.20791917
93MP0004142_abnormal_muscle_tone1.20752771
94MP0003183_abnormal_peptide_metabolism1.19836932
95MP0002272_abnormal_nervous_system1.18094781
96MP0001348_abnormal_lacrimal_gland1.16995726
97MP0003091_abnormal_cell_migration1.16890576
98MP0002184_abnormal_innervation1.16673139
99MP0002139_abnormal_hepatobiliary_system1.13663601
100MP0005167_abnormal_blood-brain_barrier1.13297819
101MP0009046_muscle_twitch1.13158580
102MP0002332_abnormal_exercise_endurance1.12184235
103MP0004811_abnormal_neuron_physiology1.12042369
104MP0003453_abnormal_keratinocyte_physiol1.11997732
105MP0002572_abnormal_emotion/affect_behav1.11873701
106MP0006292_abnormal_olfactory_placode1.11287722
107MP0002254_reproductive_system_inflammat1.08963105
108MP0004233_abnormal_muscle_weight1.08781840
109MP0001986_abnormal_taste_sensitivity1.06338021
110MP0008007_abnormal_cellular_replicative1.05268694
111MP0003283_abnormal_digestive_organ1.03670312
112MP0005623_abnormal_meninges_morphology1.01997306
113MP0001697_abnormal_embryo_size1.01934639
114MP0000465_gastrointestinal_hemorrhage1.01778954
115MP0000751_myopathy1.01069950
116MP0002638_abnormal_pupillary_reflex1.00581578
117MP0003119_abnormal_digestive_system0.99953540
118MP0009763_increased_sensitivity_to0.99512410
119MP0004883_abnormal_blood_vessel0.98939149
120MP0009745_abnormal_behavioral_response0.98477856
121MP0003861_abnormal_nervous_system0.98173630
122MP0005164_abnormal_response_to0.97236220
123MP0002166_altered_tumor_susceptibility0.95868897
124MP0002102_abnormal_ear_morphology0.95858167
125MP0004808_abnormal_hematopoietic_stem0.95125929
126MP0002085_abnormal_embryonic_tissue0.93899317
127MP0002882_abnormal_neuron_morphology0.93618568
128MP0001851_eye_inflammation0.93081146
129MP0005394_taste/olfaction_phenotype0.92906237
130MP0005499_abnormal_olfactory_system0.92906237
131MP0008877_abnormal_DNA_methylation0.92483971
132MP0003656_abnormal_erythrocyte_physiolo0.92131849
133MP0002152_abnormal_brain_morphology0.89446159
134MP0005165_increased_susceptibility_to0.89110607
135MP0000049_abnormal_middle_ear0.88827640
136MP0000358_abnormal_cell_content/0.87756762
137MP0008569_lethality_at_weaning0.87545892
138MP0002933_joint_inflammation0.86529349
139MP0005390_skeleton_phenotype0.86512095
140MP0003045_fibrosis0.86279184
141MP0002080_prenatal_lethality0.85535476
142MP0000313_abnormal_cell_death0.84433297
143MP0000249_abnormal_blood_vessel0.83682696
144MP0002084_abnormal_developmental_patter0.83357626
145MP0008789_abnormal_olfactory_epithelium0.83152293
146MP0003315_abnormal_perineum_morphology0.82946746
147MP0003806_abnormal_nucleotide_metabolis0.82103931
148MP0001542_abnormal_bone_strength0.81851985
149MP0003634_abnormal_glial_cell0.79453632
150MP0002067_abnormal_sensory_capabilities0.79236760
151MP0002006_tumorigenesis0.78207677
152MP0004145_abnormal_muscle_electrophysio0.77291498
153MP0008874_decreased_physiological_sensi0.76668039
154MP0001663_abnormal_digestive_system0.76372869
155MP0000703_abnormal_thymus_morphology0.75386197
156MP0001984_abnormal_olfaction0.75197434
157MP0001873_stomach_inflammation0.75157431
158MP0001440_abnormal_grooming_behavior0.74781349
159MP0003795_abnormal_bone_structure0.73861519
160MP0002752_abnormal_somatic_nervous0.73652575
161MP0003942_abnormal_urinary_system0.73194149
162MP0006054_spinal_hemorrhage0.72684149
163MP0003786_premature_aging0.72034360
164MP0002877_abnormal_melanocyte_morpholog0.71909351
165MP0009333_abnormal_splenocyte_physiolog0.70256596
166MP0002066_abnormal_motor_capabilities/c0.69989244
167MP0005253_abnormal_eye_physiology0.69287814
168MP0003938_abnormal_ear_development0.68842781
169MP0000537_abnormal_urethra_morphology0.68354101
170MP0003221_abnormal_cardiomyocyte_apopto0.68050059
171MP0001486_abnormal_startle_reflex0.67503775
172MP0005666_abnormal_adipose_tissue0.67203705
173MP0006035_abnormal_mitochondrial_morpho0.67100489
174MP0009765_abnormal_xenobiotic_induced0.66033701
175MP0002089_abnormal_postnatal_growth/wei0.65523934
176MP0000920_abnormal_myelination0.64839575
177MP0005384_cellular_phenotype0.64239171
178MP0003866_abnormal_defecation0.64212668
179MP0000534_abnormal_ureter_morphology0.63311782
180MP0002557_abnormal_social/conspecific_i0.62985976
181MP0001672_abnormal_embryogenesis/_devel0.62620556
182MP0005380_embryogenesis_phenotype0.62620556
183MP0003329_amyloid_beta_deposits0.62414906
184MP0003172_abnormal_lysosome_physiology0.61965680
185MP0003137_abnormal_impulse_conducting0.61539768
186MP0000631_abnormal_neuroendocrine_gland0.61423775
187MP0004924_abnormal_behavior0.61381567
188MP0005386_behavior/neurological_phenoty0.61381567
189MP0005023_abnormal_wound_healing0.59640279
190MP0005647_abnormal_sex_gland0.59309438
191MP0003279_aneurysm0.58294875
192MP0000749_muscle_degeneration0.57546530
193MP0008260_abnormal_autophagy0.57115909
194MP0000609_abnormal_liver_physiology0.52455595
195MP0005535_abnormal_body_temperature0.52026072
196MP0003646_muscle_fatigue0.50610249
197MP0005584_abnormal_enzyme/coenzyme_acti0.48854190

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)5.05042543
2Eczematoid dermatitis (HP:0000976)4.92380015
3Abnormality of liposaccharide metabolism (HP:0010968)4.87233966
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.87233966
5Abnormality of glycolipid metabolism (HP:0010969)4.87233966
6Recurrent bacterial skin infections (HP:0005406)4.86461645
7Recurrent abscess formation (HP:0002722)4.64132127
8Orchitis (HP:0100796)4.24547574
9Retrobulbar optic neuritis (HP:0100654)4.12980480
10Optic neuritis (HP:0100653)4.12980480
11Mediastinal lymphadenopathy (HP:0100721)4.12618915
12Myositis (HP:0100614)4.07316445
13Systemic lupus erythematosus (HP:0002725)3.67320435
14Recurrent gram-negative bacterial infections (HP:0005420)3.61931449
15Cerebral hypomyelination (HP:0006808)3.56269202
16Vasculitis (HP:0002633)3.50061003
17Gastrointestinal stroma tumor (HP:0100723)3.45975904
18Vacuolated lymphocytes (HP:0001922)3.42403070
19Meningitis (HP:0001287)3.39808251
20Increased cerebral lipofuscin (HP:0011813)3.31912385
21Dysostosis multiplex (HP:0000943)3.30680506
22Recurrent viral infections (HP:0004429)3.28787755
23Loss of speech (HP:0002371)3.28683223
24Stomatitis (HP:0010280)3.24986500
25Myokymia (HP:0002411)3.21398993
26Recurrent fungal infections (HP:0002841)3.13665884
27Pulmonary infiltrates (HP:0002113)3.10024741
28Elevated erythrocyte sedimentation rate (HP:0003565)3.10010600
29Recurrent skin infections (HP:0001581)3.09211915
30Cellulitis (HP:0100658)3.01061487
31Autoimmune thrombocytopenia (HP:0001973)3.00450392
32Keratoconjunctivitis sicca (HP:0001097)2.97630734
33Chronic obstructive pulmonary disease (HP:0006510)2.95885776
34Obstructive lung disease (HP:0006536)2.95885776
35Spontaneous hematomas (HP:0007420)2.91884913
36Increased IgM level (HP:0003496)2.87514804
37Colitis (HP:0002583)2.80534276
38Purpura (HP:0000979)2.79347976
39Disinhibition (HP:0000734)2.73924856
40Degeneration of anterior horn cells (HP:0002398)2.68729020
41Abnormality of the anterior horn cell (HP:0006802)2.68729020
42Urticaria (HP:0001025)2.66865637
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.66339359
44Keratoconjunctivitis (HP:0001096)2.66243187
45Agammaglobulinemia (HP:0004432)2.65937637
46Increased IgE level (HP:0003212)2.64440851
47Encephalitis (HP:0002383)2.62979360
48Chronic mucocutaneous candidiasis (HP:0002728)2.62249445
49Recurrent cutaneous fungal infections (HP:0011370)2.62249445
50Hemoptysis (HP:0002105)2.61710715
51Petechiae (HP:0000967)2.59853432
52Abnormality of the labia minora (HP:0012880)2.58970022
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.56917871
54Gingivitis (HP:0000230)2.53745680
55Interstitial pulmonary disease (HP:0006530)2.52856043
56Arterial thrombosis (HP:0004420)2.50722595
57Acute necrotizing encephalopathy (HP:0006965)2.49221815
58Gastrointestinal infarctions (HP:0005244)2.48836696
59Birth length less than 3rd percentile (HP:0003561)2.47197232
60IgA deficiency (HP:0002720)2.47034687
61T lymphocytopenia (HP:0005403)2.46692566
62Abnormal number of incisors (HP:0011064)2.44260669
63Inflammation of the large intestine (HP:0002037)2.43830948
64Restrictive lung disease (HP:0002091)2.43661355
65Abnormality of glycolysis (HP:0004366)2.43029041
66Increased serum pyruvate (HP:0003542)2.43029041
67Atrophy/Degeneration involving motor neurons (HP:0007373)2.41620986
68Abnormality of T cell number (HP:0011839)2.39372355
69Recurrent bronchitis (HP:0002837)2.39298591
70Lymphopenia (HP:0001888)2.38370230
71Osteomyelitis (HP:0002754)2.37734783
72Autoimmune hemolytic anemia (HP:0001890)2.37588936
73Abnormality of polysaccharide metabolism (HP:0011012)2.37074264
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.37074264
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.37074264
76Hypergammaglobulinemia (HP:0010702)2.36799529
77Myocardial infarction (HP:0001658)2.36316238
78Abnormal mitochondria in muscle tissue (HP:0008316)2.35812324
79Amyloidosis (HP:0011034)2.34811663
80Chest pain (HP:0100749)2.34710160
81Hepatosplenomegaly (HP:0001433)2.34600264
82Urinary glycosaminoglycan excretion (HP:0003541)2.32574498
83Mucopolysacchariduria (HP:0008155)2.32574498
84Gastrointestinal inflammation (HP:0004386)2.30540776
85Emphysema (HP:0002097)2.28887121
86Gangrene (HP:0100758)2.26508037
87Increased serum ferritin (HP:0003281)2.26023152
88Supernumerary spleens (HP:0009799)2.25732388
89Abnormality of cells of the lymphoid lineage (HP:0012140)2.25457607
90Patellar aplasia (HP:0006443)2.24775054
91Epistaxis (HP:0000421)2.22775391
92Hematochezia (HP:0002573)2.21331349
93Premature loss of primary teeth (HP:0006323)2.19171119
94Mitochondrial inheritance (HP:0001427)2.18717172
95Prolonged bleeding time (HP:0003010)2.17150961
96Glomerulonephritis (HP:0000099)2.17060678
97Failure to thrive in infancy (HP:0001531)2.16581994
98Recurrent sinusitis (HP:0011108)2.14830219
99Arthralgia (HP:0002829)2.14362217
100Gingival bleeding (HP:0000225)2.13492990
101Asymmetric septal hypertrophy (HP:0001670)2.13472745
102Basal ganglia calcification (HP:0002135)2.13337156
103Recurrent pneumonia (HP:0006532)2.12755658
104Mutism (HP:0002300)2.12420567
105Polyneuropathy (HP:0001271)2.12102328
106Neuroendocrine neoplasm (HP:0100634)2.12007059
107Abnormality of the pleura (HP:0002103)2.11325223
108Ependymoma (HP:0002888)2.09058142
109Emotional lability (HP:0000712)2.08959936
110Selective tooth agenesis (HP:0001592)2.06744310
111Aplasia/Hypoplasia of the patella (HP:0006498)2.05698031
112Rectal fistula (HP:0100590)2.04742926
113Rectovaginal fistula (HP:0000143)2.04742926
114Pulmonary embolism (HP:0002204)2.04022023
115Breast hypoplasia (HP:0003187)2.03990626
116Pheochromocytoma (HP:0002666)2.03788802
117Abnormality of T cells (HP:0002843)2.03461954
118Amaurosis fugax (HP:0100576)2.03196941
119Joint swelling (HP:0001386)2.01359369
120Recurrent lower respiratory tract infections (HP:0002783)2.01071627
121IgM deficiency (HP:0002850)2.00126745
122Leukocytosis (HP:0001974)2.00035742
123Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98947512
124Hypertensive crisis (HP:0100735)1.96278555
125Postnatal microcephaly (HP:0005484)1.95257343
126Vertigo (HP:0002321)1.95034302
127Delusions (HP:0000746)1.94705136
128Visual hallucinations (HP:0002367)1.93504719
129Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91645173
130Limb dystonia (HP:0002451)1.91210904
131Abnormality of cells of the erythroid lineage (HP:0012130)1.90743033
132Aplasia involving forearm bones (HP:0009822)1.90688672
133Absent forearm bone (HP:0003953)1.90688672
134CNS hypomyelination (HP:0003429)1.89789552
135Absent radius (HP:0003974)1.89340919
136Broad alveolar ridges (HP:0000187)1.88304670
137Neoplasm of the peripheral nervous system (HP:0100007)1.86859503
138Agnosia (HP:0010524)1.83548368
139Hepatocellular necrosis (HP:0001404)1.83443679
140Increased CSF lactate (HP:0002490)1.80600657
141High anterior hairline (HP:0009890)1.80581187
142Shoulder girdle muscle weakness (HP:0003547)1.76774280
143Atonic seizures (HP:0010819)1.76181229
144Reticulocytopenia (HP:0001896)1.76113240
145Lissencephaly (HP:0001339)1.76106381
146Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75814834
147Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75814834
148Trismus (HP:0000211)1.73783028
149Amyotrophic lateral sclerosis (HP:0007354)1.72947588
150Tongue fasciculations (HP:0001308)1.72552785
151Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72440062
152Orthostatic hypotension (HP:0001278)1.72116055
153Asplenia (HP:0001746)1.71107600
154Aplastic anemia (HP:0001915)1.70765812
155Stenosis of the external auditory canal (HP:0000402)1.68893805
156Progressive macrocephaly (HP:0004481)1.68338284
157Ankle clonus (HP:0011448)1.68330878
158Severe visual impairment (HP:0001141)1.68322379
159Leukodystrophy (HP:0002415)1.66941183
160Focal motor seizures (HP:0011153)1.66800140
161Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.66639526
162Carpal bone hypoplasia (HP:0001498)1.66229115
163Abnormal hair whorl (HP:0010721)1.64924979
164Broad distal phalanx of finger (HP:0009836)1.61975540
165Vaginal fistula (HP:0004320)1.61857174
1663-Methylglutaconic aciduria (HP:0003535)1.60872418
167Colon cancer (HP:0003003)1.60112222
168Exercise intolerance (HP:0003546)1.59314168
169Abnormality of binocular vision (HP:0011514)1.58095414
170Diplopia (HP:0000651)1.58095414
171Unsteady gait (HP:0002317)1.58049612
172Abnormal number of erythroid precursors (HP:0012131)1.57909701
173Fused cervical vertebrae (HP:0002949)1.56819081
174Aplasia/Hypoplasia of the spleen (HP:0010451)1.56190279
175Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55935894
176Increased hepatocellular lipid droplets (HP:0006565)1.55073571
177Septo-optic dysplasia (HP:0100842)1.53123920
178Polyphagia (HP:0002591)1.52843117
179Partial duplication of the phalanx of hand (HP:0009999)1.52082662
180Partial duplication of thumb phalanx (HP:0009944)1.52033007
181Intestinal fistula (HP:0100819)1.51506774
182Muscle fibrillation (HP:0010546)1.51134397
183Personality changes (HP:0000751)1.51091105
184Medulloblastoma (HP:0002885)1.50872788
185Poor suck (HP:0002033)1.49439679
186Supranuclear gaze palsy (HP:0000605)1.48916562
187Increased serum lactate (HP:0002151)1.48811825
188Abnormal autonomic nervous system physiology (HP:0012332)1.48640568
189Split foot (HP:0001839)1.47892659
190Dysautonomia (HP:0002459)1.47199872
191Abnormality of the ileum (HP:0001549)1.47004353
192Gait imbalance (HP:0002141)1.46382083
193Epileptic encephalopathy (HP:0200134)1.46195373
194Abnormal sex determination (HP:0012244)1.43243563
195Sex reversal (HP:0012245)1.43243563
196Diminished motivation (HP:0000745)1.42878932
197Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.42236909
198Abnormality of abdominal situs (HP:0011620)1.42042554
199Abdominal situs inversus (HP:0003363)1.42042554
200Hemiparesis (HP:0001269)1.41440615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.59807688
2MAP3K143.18684113
3TYK22.91871420
4MAP3K92.73694518
5ERN12.71853131
6TESK22.68685322
7IRAK32.67321467
8ARAF2.61661679
9TBK12.56093473
10IRAK42.50561127
11WEE12.40784363
12TSSK62.26769203
13IKBKE2.19490439
14UHMK12.14588439
15CSK2.13460905
16NEK12.06115370
17MAP3K132.03356739
18GRK71.97999232
19JAK31.95467093
20CDK191.92013854
21JAK11.80986719
22STK161.80719902
23IKBKB1.79566199
24DYRK21.77200871
25LIMK11.74392238
26BMPR21.73459885
27MINK11.70691670
28SYK1.66529734
29NME21.65042329
30TGFBR21.62242345
31MAP3K121.60131445
32PNCK1.59588546
33BTK1.59202829
34MAP2K31.57227519
35CCNB11.56916548
36DDR21.56213303
37CSF1R1.54153417
38SIK31.53318072
39EIF2AK11.52644294
40MARK11.48446194
41CDK141.47472135
42CDK181.44045108
43ZAP701.41681288
44MAP3K31.40876739
45TLK11.40396577
46FES1.40376221
47BCR1.38526609
48BRAF1.37003707
49CDK151.35339582
50NEK91.33018435
51VRK11.30585520
52LYN1.30212287
53MAPK131.29559472
54KSR11.29526506
55CDK11A1.27656523
56DAPK11.26659838
57KIT1.25964491
58BRSK11.25813922
59CDC42BPA1.24210508
60JAK21.23631943
61MAPKAPK31.23378690
62TXK1.21593118
63TESK11.20786439
64RIPK11.20196313
65AURKA1.17909585
66HCK1.17620670
67PLK11.15974472
68TAOK11.15872327
69DYRK31.15296760
70CDC71.15216260
71MAP3K11.14654494
72PIM21.13950546
73NTRK21.12946452
74PAK11.10880586
75TNK21.06547960
76ACVR1B1.04522522
77PAK41.03346132
78FGFR41.02172515
79PASK1.01314199
80GRK51.00876759
81STK240.99080819
82TEC0.98446198
83IRAK10.98240567
84EPHB10.96438480
85PLK30.95211272
86RPS6KB20.94274998
87KSR20.94224867
88NEK20.93654398
89LCK0.92656240
90MATK0.91591918
91CHUK0.91528155
92TYRO30.89643811
93NME10.88577591
94PLK20.88032838
95ITK0.85352058
96ILK0.83484161
97PAK60.81948855
98NTRK10.81272345
99MARK30.79638735
100MAPK70.78738150
101TRIB30.78323862
102MOS0.78159780
103TGFBR10.73509276
104IRAK20.73066968
105TTK0.72560983
106PRKD30.71807467
107EPHA30.71159434
108LATS20.71133577
109TTN0.70755640
110MAPK120.70108550
111MAP3K50.69860156
112EEF2K0.68151323
113ROCK20.66664625
114PDK10.65550938
115MAPKAPK50.64285188
116PRPF4B0.63396630
117RAF10.62483507
118PDPK10.60072302
119FGFR30.59700323
120PRKCQ0.59597672
121SCYL20.59067566
122CHEK20.58831096
123MAP3K100.58304619
124CDK80.58287381
125MST40.55334290
126MAP3K110.54650363
127CDK50.54151709
128DAPK30.54087310
129GRK60.53621642
130CDK70.53359152
131SMG10.51620917
132MAPK40.50926513
133BRSK20.50725431
134NTRK30.50661169
135HIPK20.50657131
136TAOK30.50541797
137ADRBK10.50479927
138PHKG20.49763530
139PHKG10.49763530
140PIM10.49505060
141PRKCI0.49338640
142ADRBK20.49147291
143MAP3K80.48887672
144FGR0.47744169
145STK100.47117448
146BLK0.47114046
147ALK0.46940614
148CSNK1G30.46739325
149MAP3K40.45861786
150ATR0.45011530
151ICK0.44155345
152RPS6KA40.43839303
153CLK10.42954938
154CDK60.42065504
155SIK10.41335538
156MAPK110.41037787
157MAPKAPK20.40725755
158MAP4K10.40369505
159BMX0.39958642
160CDK40.39552025
161PIK3CG0.38902715
162CHEK10.38633742
163RIPK40.38550317
164TAOK20.37693969
165TRPM70.37234536
166CDK20.35702055
167LRRK20.35340107
168FYN0.34484738
169SIK20.34280183
170ABL10.32824021
171MARK20.31883491
172PRKCD0.30522681
173RPS6KL10.29579180
174RPS6KC10.29579180
175KDR0.29487678
176INSR0.27818698
177YES10.27367950
178PKN10.27354411
179ABL20.25924992
180EGFR0.23049155

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.45132624
2Proteasome_Homo sapiens_hsa030503.32099312
3Graft-versus-host disease_Homo sapiens_hsa053323.09051583
4Autoimmune thyroid disease_Homo sapiens_hsa053203.02056164
5Asthma_Homo sapiens_hsa053102.94966411
6Leishmaniasis_Homo sapiens_hsa051402.92240897
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.88839481
8Staphylococcus aureus infection_Homo sapiens_hsa051502.80102314
9Ribosome_Homo sapiens_hsa030102.78899139
10DNA replication_Homo sapiens_hsa030302.78894448
11Osteoclast differentiation_Homo sapiens_hsa043802.56383185
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.53939601
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.43323898
14Spliceosome_Homo sapiens_hsa030402.42890385
15Mismatch repair_Homo sapiens_hsa034302.41954189
16NF-kappa B signaling pathway_Homo sapiens_hsa040642.35434545
17Parkinsons disease_Homo sapiens_hsa050122.22158152
18Base excision repair_Homo sapiens_hsa034102.20677659
19Oxidative phosphorylation_Homo sapiens_hsa001902.19317994
20Other glycan degradation_Homo sapiens_hsa005112.11942552
21B cell receptor signaling pathway_Homo sapiens_hsa046622.06916716
22RNA polymerase_Homo sapiens_hsa030202.06291912
23Tuberculosis_Homo sapiens_hsa051522.02148339
24RNA transport_Homo sapiens_hsa030131.82945525
25Influenza A_Homo sapiens_hsa051641.82754219
26Malaria_Homo sapiens_hsa051441.82471913
27TNF signaling pathway_Homo sapiens_hsa046681.71458322
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71207516
29Nucleotide excision repair_Homo sapiens_hsa034201.70454728
30Huntingtons disease_Homo sapiens_hsa050161.70243360
31Toxoplasmosis_Homo sapiens_hsa051451.70161380
32Hematopoietic cell lineage_Homo sapiens_hsa046401.69390914
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69239535
34Synaptic vesicle cycle_Homo sapiens_hsa047211.68958455
35Cell cycle_Homo sapiens_hsa041101.66669032
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63616482
37Pertussis_Homo sapiens_hsa051331.62400262
38Measles_Homo sapiens_hsa051621.61411511
39Lysosome_Homo sapiens_hsa041421.60446135
40Legionellosis_Homo sapiens_hsa051341.56627038
41Herpes simplex infection_Homo sapiens_hsa051681.55898462
42Homologous recombination_Homo sapiens_hsa034401.45871188
43Alzheimers disease_Homo sapiens_hsa050101.43483584
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40501116
45Oocyte meiosis_Homo sapiens_hsa041141.36947502
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35099297
47Cardiac muscle contraction_Homo sapiens_hsa042601.34676497
48African trypanosomiasis_Homo sapiens_hsa051431.29457738
49Pyrimidine metabolism_Homo sapiens_hsa002401.29156273
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.27360341
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24793391
52Chemokine signaling pathway_Homo sapiens_hsa040621.23696131
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21540603
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19787561
55mRNA surveillance pathway_Homo sapiens_hsa030151.18618024
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.15253465
57Hepatitis C_Homo sapiens_hsa051601.12317753
58Collecting duct acid secretion_Homo sapiens_hsa049661.11711624
59Nicotine addiction_Homo sapiens_hsa050331.11257533
60Hepatitis B_Homo sapiens_hsa051611.08710090
61Vibrio cholerae infection_Homo sapiens_hsa051101.08608824
62Epstein-Barr virus infection_Homo sapiens_hsa051691.07916827
63T cell receptor signaling pathway_Homo sapiens_hsa046601.07660388
64Apoptosis_Homo sapiens_hsa042101.02591098
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01208447
66Acute myeloid leukemia_Homo sapiens_hsa052210.99637058
67Shigellosis_Homo sapiens_hsa051310.94231713
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91113900
69Basal transcription factors_Homo sapiens_hsa030220.90640879
70Non-homologous end-joining_Homo sapiens_hsa034500.89435144
71Systemic lupus erythematosus_Homo sapiens_hsa053220.88654452
72RNA degradation_Homo sapiens_hsa030180.87879950
73Dopaminergic synapse_Homo sapiens_hsa047280.87721080
74Protein export_Homo sapiens_hsa030600.85859300
75Fanconi anemia pathway_Homo sapiens_hsa034600.83670507
76GABAergic synapse_Homo sapiens_hsa047270.82577285
77Colorectal cancer_Homo sapiens_hsa052100.82235168
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81359816
79Gap junction_Homo sapiens_hsa045400.80983680
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80951490
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80291215
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79627372
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77961367
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77516547
85Purine metabolism_Homo sapiens_hsa002300.77165975
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76625163
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76285904
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.74610036
89Prion diseases_Homo sapiens_hsa050200.73523647
90Prolactin signaling pathway_Homo sapiens_hsa049170.71840736
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.71728589
92Morphine addiction_Homo sapiens_hsa050320.70327079
93Olfactory transduction_Homo sapiens_hsa047400.70326940
94Long-term potentiation_Homo sapiens_hsa047200.69390953
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69262096
96Platelet activation_Homo sapiens_hsa046110.69150753
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68261497
98Hedgehog signaling pathway_Homo sapiens_hsa043400.65478297
99Amoebiasis_Homo sapiens_hsa051460.64410886
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64108010
101Alcoholism_Homo sapiens_hsa050340.63648842
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.63291050
103p53 signaling pathway_Homo sapiens_hsa041150.63274318
104Notch signaling pathway_Homo sapiens_hsa043300.62803052
105Circadian entrainment_Homo sapiens_hsa047130.62425648
106Type I diabetes mellitus_Homo sapiens_hsa049400.62413607
107Serotonergic synapse_Homo sapiens_hsa047260.62248589
108Hippo signaling pathway_Homo sapiens_hsa043900.60203808
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58660986
110HTLV-I infection_Homo sapiens_hsa051660.56521489
111Amphetamine addiction_Homo sapiens_hsa050310.56420883
112Pancreatic cancer_Homo sapiens_hsa052120.55636284
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55326707
114Phagosome_Homo sapiens_hsa041450.54503998
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54488673
116Endocytosis_Homo sapiens_hsa041440.54410202
117Long-term depression_Homo sapiens_hsa047300.53027269
118Glutamatergic synapse_Homo sapiens_hsa047240.53007205
119Primary immunodeficiency_Homo sapiens_hsa053400.52716745
120Viral carcinogenesis_Homo sapiens_hsa052030.50946523
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50580713
122Cholinergic synapse_Homo sapiens_hsa047250.49886538
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49619182
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49288824
125N-Glycan biosynthesis_Homo sapiens_hsa005100.48155191
126Viral myocarditis_Homo sapiens_hsa054160.47839304
127Chronic myeloid leukemia_Homo sapiens_hsa052200.47066611
128VEGF signaling pathway_Homo sapiens_hsa043700.47063394
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.46824115
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46359461
131Basal cell carcinoma_Homo sapiens_hsa052170.45531899
132Axon guidance_Homo sapiens_hsa043600.45305305
133Bladder cancer_Homo sapiens_hsa052190.45291262
134Oxytocin signaling pathway_Homo sapiens_hsa049210.43912790
135Antigen processing and presentation_Homo sapiens_hsa046120.43298943
136Cocaine addiction_Homo sapiens_hsa050300.43160224
137Rheumatoid arthritis_Homo sapiens_hsa053230.43057997
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42355770
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41606083
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41393004
141Phototransduction_Homo sapiens_hsa047440.40030966
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39839005
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39642065
144Complement and coagulation cascades_Homo sapiens_hsa046100.38662250
145Renal cell carcinoma_Homo sapiens_hsa052110.38512527
146Salmonella infection_Homo sapiens_hsa051320.37679862
147HIF-1 signaling pathway_Homo sapiens_hsa040660.37140719
148Pathways in cancer_Homo sapiens_hsa052000.36878373
149GnRH signaling pathway_Homo sapiens_hsa049120.36595855
150Melanogenesis_Homo sapiens_hsa049160.36432813
151MAPK signaling pathway_Homo sapiens_hsa040100.35944359
152Wnt signaling pathway_Homo sapiens_hsa043100.35908741
153Type II diabetes mellitus_Homo sapiens_hsa049300.35614835
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35553444
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35036783
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32293595
157Non-small cell lung cancer_Homo sapiens_hsa052230.32142813
158Galactose metabolism_Homo sapiens_hsa000520.31948876
159Insulin resistance_Homo sapiens_hsa049310.31208132
160Sphingolipid metabolism_Homo sapiens_hsa006000.27263346
161Phospholipase D signaling pathway_Homo sapiens_hsa040720.24617604
162Pentose phosphate pathway_Homo sapiens_hsa000300.23962086
163FoxO signaling pathway_Homo sapiens_hsa040680.19213690
164Dorso-ventral axis formation_Homo sapiens_hsa043200.17733508
165PPAR signaling pathway_Homo sapiens_hsa033200.15718943
166Small cell lung cancer_Homo sapiens_hsa052220.14811958
167Insulin signaling pathway_Homo sapiens_hsa049100.13425428
168Prostate cancer_Homo sapiens_hsa052150.12130160

Most similar genes based on co-expression Upload to Enrichr

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