

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | sarcomere organization (GO:0045214) | 9.62476457 |
| 2 | cardiac myofibril assembly (GO:0055003) | 9.09099401 |
| 3 | myofibril assembly (GO:0030239) | 8.05775706 |
| 4 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 7.90395814 |
| 5 | skeletal muscle contraction (GO:0003009) | 7.58204399 |
| 6 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 7.17870499 |
| 7 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 7.03309679 |
| 8 | actin-myosin filament sliding (GO:0033275) | 7.01756977 |
| 9 | muscle filament sliding (GO:0030049) | 7.01756977 |
| 10 | cardiac muscle contraction (GO:0060048) | 6.99414634 |
| 11 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 6.93060155 |
| 12 | cardiac muscle cell development (GO:0055013) | 6.66202009 |
| 13 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 6.63687653 |
| 14 | plasma membrane repair (GO:0001778) | 6.29244122 |
| 15 | tricarboxylic acid cycle (GO:0006099) | 6.29135725 |
| 16 | cardiac cell development (GO:0055006) | 6.25816933 |
| 17 | regulation of relaxation of muscle (GO:1901077) | 6.23963665 |
| 18 | regulation of actin filament-based movement (GO:1903115) | 6.23270055 |
| 19 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 6.20505771 |
| 20 | cardiac muscle tissue morphogenesis (GO:0055008) | 6.11811826 |
| 21 | adult heart development (GO:0007512) | 6.08349018 |
| 22 | actomyosin structure organization (GO:0031032) | 6.02144226 |
| 23 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 5.99312622 |
| 24 | ventricular cardiac muscle cell action potential (GO:0086005) | 5.89963657 |
| 25 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 5.84306568 |
| 26 | cardiac muscle hypertrophy (GO:0003300) | 5.83714512 |
| 27 | actin-mediated cell contraction (GO:0070252) | 5.81549648 |
| 28 | response to muscle activity (GO:0014850) | 5.76648017 |
| 29 | regulation of skeletal muscle contraction (GO:0014819) | 5.76089537 |
| 30 | striated muscle hypertrophy (GO:0014897) | 5.52503238 |
| 31 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 5.47408185 |
| 32 | muscle tissue morphogenesis (GO:0060415) | 5.45414852 |
| 33 | regulation of sarcomere organization (GO:0060297) | 5.38474564 |
| 34 | striated muscle contraction (GO:0006941) | 5.34605927 |
| 35 | heart process (GO:0003015) | 5.26200416 |
| 36 | heart contraction (GO:0060047) | 5.26200416 |
| 37 | heart trabecula formation (GO:0060347) | 5.23028479 |
| 38 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 5.16384689 |
| 39 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.11338182 |
| 40 | regulation of striated muscle contraction (GO:0006942) | 5.11333982 |
| 41 | regulation of cell communication by electrical coupling (GO:0010649) | 5.01501064 |
| 42 | carnitine shuttle (GO:0006853) | 5.01379359 |
| 43 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 5.01084701 |
| 44 | regulation of the force of heart contraction (GO:0002026) | 4.95632832 |
| 45 | muscle hypertrophy (GO:0014896) | 4.89679135 |
| 46 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 4.88718637 |
| 47 | cell communication involved in cardiac conduction (GO:0086065) | 4.85831039 |
| 48 | muscle system process (GO:0003012) | 4.75651323 |
| 49 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 4.70209643 |
| 50 | regulation of membrane repolarization (GO:0060306) | 4.66063575 |
| 51 | striated muscle adaptation (GO:0014888) | 4.47327762 |
| 52 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.41462398 |
| 53 | skeletal muscle adaptation (GO:0043501) | 4.39844299 |
| 54 | actin filament-based movement (GO:0030048) | 4.38758669 |
| 55 | regulation of cardiac muscle contraction (GO:0055117) | 4.34558859 |
| 56 | regulation of cardiac muscle cell contraction (GO:0086004) | 4.32088987 |
| 57 | fatty acid transmembrane transport (GO:1902001) | 4.31104698 |
| 58 | cell communication by electrical coupling (GO:0010644) | 4.29590048 |
| 59 | regulation of coenzyme metabolic process (GO:0051196) | 4.28653048 |
| 60 | regulation of cofactor metabolic process (GO:0051193) | 4.28653048 |
| 61 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 4.25843842 |
| 62 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 4.16182923 |
| 63 | regulation of heart rate (GO:0002027) | 4.12148786 |
| 64 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 4.11964539 |
| 65 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.11791004 |
| 66 | ATP synthesis coupled proton transport (GO:0015986) | 4.11664058 |
| 67 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.11664058 |
| 68 | cardiac muscle cell action potential (GO:0086001) | 4.11568144 |
| 69 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 4.10884990 |
| 70 | muscle fiber development (GO:0048747) | 4.07486340 |
| 71 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 4.06156139 |
| 72 | muscle hypertrophy in response to stress (GO:0003299) | 4.06156139 |
| 73 | cardiac muscle adaptation (GO:0014887) | 4.06156139 |
| 74 | negative regulation of protein localization to cell surface (GO:2000009) | 4.02571253 |
| 75 | negative regulation of striated muscle cell apoptotic process (GO:0010664) | 4.01124895 |
| 76 | regulation of ATPase activity (GO:0043462) | 3.97943063 |
| 77 | regulation of ATP catabolic process (GO:1903289) | 3.97943063 |
| 78 | respiratory electron transport chain (GO:0022904) | 3.96124403 |
| 79 | negative regulation of potassium ion transport (GO:0043267) | 3.94465323 |
| 80 | skeletal muscle fiber development (GO:0048741) | 3.94168927 |
| 81 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.93088829 |
| 82 | regulation of cardioblast differentiation (GO:0051890) | 3.89264421 |
| 83 | relaxation of cardiac muscle (GO:0055119) | 3.87816807 |
| 84 | oxygen transport (GO:0015671) | 3.85576721 |
| 85 | regulation of heart contraction (GO:0008016) | 3.84848520 |
| 86 | NADH metabolic process (GO:0006734) | 3.84762951 |
| 87 | electron transport chain (GO:0022900) | 3.84300696 |
| 88 | muscle cell cellular homeostasis (GO:0046716) | 3.82409916 |
| 89 | striated muscle atrophy (GO:0014891) | 3.80563222 |
| 90 | creatine metabolic process (GO:0006600) | 3.78445561 |
| 91 | myotube cell development (GO:0014904) | 3.76696928 |
| 92 | 2-oxoglutarate metabolic process (GO:0006103) | 3.76667825 |
| 93 | oxidative phosphorylation (GO:0006119) | 3.71086398 |
| 94 | striated muscle cell development (GO:0055002) | 3.71080724 |
| 95 | carnitine transmembrane transport (GO:1902603) | 3.69472974 |
| 96 | ventricular cardiac muscle cell development (GO:0055015) | 3.65630004 |
| 97 | muscle adaptation (GO:0043500) | 3.62489241 |
| 98 | positive regulation of cation channel activity (GO:2001259) | 3.62081600 |
| 99 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.59637876 |
| 100 | positive regulation of heart rate (GO:0010460) | 3.58084523 |
| 101 | regulation of muscle system process (GO:0090257) | 3.57973818 |
| 102 | cardiac conduction (GO:0061337) | 3.57949684 |
| 103 | regulation of sequestering of triglyceride (GO:0010889) | 3.53406536 |
| 104 | skeletal muscle tissue development (GO:0007519) | 3.51172123 |
| 105 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.51013072 |
| 106 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.51013072 |
| 107 | positive regulation of heart contraction (GO:0045823) | 3.50826928 |
| 108 | regulation of sulfur metabolic process (GO:0042762) | 3.49200555 |
| 109 | response to caffeine (GO:0031000) | 3.48871588 |
| 110 | regulation of heart rate by cardiac conduction (GO:0086091) | 3.48374580 |
| 111 | regulation of myoblast differentiation (GO:0045661) | 3.47292673 |
| 112 | muscle contraction (GO:0006936) | 3.46937672 |
| 113 | muscle cell development (GO:0055001) | 3.46576719 |
| 114 | muscle cell fate commitment (GO:0042693) | 3.46347435 |
| 115 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.44861187 |
| 116 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.44861187 |
| 117 | cardiac chamber formation (GO:0003207) | 3.43901229 |
| 118 | response to epinephrine (GO:0071871) | 3.41002731 |
| 119 | regulation of muscle contraction (GO:0006937) | 3.38745924 |
| 120 | muscle atrophy (GO:0014889) | 3.37794384 |
| 121 | amino-acid betaine transport (GO:0015838) | 3.35911497 |
| 122 | carnitine transport (GO:0015879) | 3.35911497 |
| 123 | trabecula formation (GO:0060343) | 3.32341197 |
| 124 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.32292012 |
| 125 | glycogen catabolic process (GO:0005980) | 3.31525112 |
| 126 | response to inactivity (GO:0014854) | 3.28570727 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 6.54306889 |
| 2 | * EP300_21415370_ChIP-Seq_HL-1_Mouse | 5.09075118 |
| 3 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 4.45512982 |
| 4 | * TBX20_22328084_ChIP-Seq_HEART_Mouse | 4.26465697 |
| 5 | * TBX20_22080862_ChIP-Seq_HEART_Mouse | 4.26465697 |
| 6 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.89520485 |
| 7 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 3.76366010 |
| 8 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 3.27309654 |
| 9 | ZNF263_19887448_ChIP-Seq_K562_Human | 3.25996451 |
| 10 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.05927166 |
| 11 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.94684628 |
| 12 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.83105336 |
| 13 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.73388355 |
| 14 | * GATA4_21415370_ChIP-Seq_HL-1_Mouse | 2.45806643 |
| 15 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.35705612 |
| 16 | * EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 2.16397964 |
| 17 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.15231436 |
| 18 | VDR_22108803_ChIP-Seq_LS180_Human | 2.07995964 |
| 19 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 2.07476289 |
| 20 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.04833079 |
| 21 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.02183260 |
| 22 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.96838416 |
| 23 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.92483200 |
| 24 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.89587743 |
| 25 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.87154160 |
| 26 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.82396029 |
| 27 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.77516651 |
| 28 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.57926985 |
| 29 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.54170974 |
| 30 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.51318987 |
| 31 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.45992453 |
| 32 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.45689798 |
| 33 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.42551796 |
| 34 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.41129952 |
| 35 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.39779016 |
| 36 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.36515575 |
| 37 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.32562282 |
| 38 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.31459001 |
| 39 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.29861298 |
| 40 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.27574612 |
| 41 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.26892926 |
| 42 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.26757390 |
| 43 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.26684595 |
| 44 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.24882610 |
| 45 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.21898757 |
| 46 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.21645825 |
| 47 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.19996980 |
| 48 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.19653084 |
| 49 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.19647041 |
| 50 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.19554429 |
| 51 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.18846274 |
| 52 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.18774454 |
| 53 | GATA1_19941826_ChIP-Seq_K562_Human | 1.18721065 |
| 54 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.17800168 |
| 55 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.11400775 |
| 56 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.11181150 |
| 57 | GATA1_22025678_ChIP-Seq_K562_Human | 1.10900387 |
| 58 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.10706700 |
| 59 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.10397654 |
| 60 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.04928454 |
| 61 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.04296664 |
| 62 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.03957869 |
| 63 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.03701710 |
| 64 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.02925101 |
| 65 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.02925101 |
| 66 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.02124268 |
| 67 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.01729296 |
| 68 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.00357900 |
| 69 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.00322275 |
| 70 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 0.98655088 |
| 71 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.97389295 |
| 72 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.97218779 |
| 73 | ATF3_27146783_Chip-Seq_COLON_Human | 0.96956983 |
| 74 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.96846453 |
| 75 | * LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96352682 |
| 76 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.95578251 |
| 77 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.95451043 |
| 78 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.94410622 |
| 79 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 0.93286574 |
| 80 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.91382706 |
| 81 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 0.91064353 |
| 82 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.90920342 |
| 83 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.90836827 |
| 84 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.90377495 |
| 85 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.90042861 |
| 86 | GATA2_19941826_ChIP-Seq_K562_Human | 0.89975063 |
| 87 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.89245622 |
| 88 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.89034953 |
| 89 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.87797372 |
| 90 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.87288764 |
| 91 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.87211853 |
| 92 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.86686402 |
| 93 | SPI1_23127762_ChIP-Seq_K562_Human | 0.86140657 |
| 94 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 0.85486215 |
| 95 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.85471288 |
| 96 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.85312829 |
| 97 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.85001525 |
| 98 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.84461323 |
| 99 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.83527423 |
| 100 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.83475359 |
| 101 | * P68_20966046_ChIP-Seq_HELA_Human | 0.83174228 |
| 102 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.82895805 |
| 103 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.82308134 |
| 104 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.81657564 |
| 105 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.81281519 |
| 106 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.81144079 |
| 107 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.80337124 |
| 108 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80170444 |
| 109 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.79449020 |
| 110 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.78270316 |
| 111 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.78141269 |
| 112 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.77984258 |
| 113 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.77506023 |
| 114 | CJUN_26792858_Chip-Seq_BT549_Human | 0.77224933 |
| 115 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 0.77125083 |
| 116 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.77104265 |
| 117 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.76858613 |
| 118 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.76582695 |
| 119 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.76169577 |
| 120 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.75613364 |
| 121 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.75565405 |
| 122 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.74802615 |
| 123 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.73813049 |
| 124 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.73547540 |
| 125 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.73493083 |
| 126 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 0.73398111 |
| 127 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.73133003 |
| 128 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.72498792 |
| 129 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.72379042 |
| 130 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.72377027 |
| 131 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.72122488 |
| 132 | TBL1_22424771_ChIP-Seq_293T_Human | 0.71562628 |
| 133 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.71225700 |
| 134 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.71159563 |
| 135 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.70396837 |
| 136 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.69676882 |
| 137 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 0.69673354 |
| 138 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.69227820 |
| 139 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.68317823 |
| 140 | PRDM14_21183938_ChIP-Seq_MESCs_Mouse | 0.67947541 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 7.28193538 |
| 2 | MP0004084_abnormal_cardiac_muscle | 5.94564402 |
| 3 | MP0003646_muscle_fatigue | 5.62970937 |
| 4 | MP0000751_myopathy | 5.17571706 |
| 5 | MP0004215_abnormal_myocardial_fiber | 4.94580876 |
| 6 | MP0004036_abnormal_muscle_relaxation | 4.26820913 |
| 7 | MP0005330_cardiomyopathy | 4.01718927 |
| 8 | MP0000749_muscle_degeneration | 3.86183935 |
| 9 | MP0002972_abnormal_cardiac_muscle | 3.22388121 |
| 10 | MP0004087_abnormal_muscle_fiber | 3.08749897 |
| 11 | MP0008775_abnormal_heart_ventricle | 3.03471404 |
| 12 | MP0003137_abnormal_impulse_conducting | 3.02025798 |
| 13 | MP0000750_abnormal_muscle_regeneration | 2.71669660 |
| 14 | MP0005385_cardiovascular_system_phenoty | 2.71152279 |
| 15 | MP0001544_abnormal_cardiovascular_syste | 2.71152279 |
| 16 | MP0010630_abnormal_cardiac_muscle | 2.68351353 |
| 17 | MP0005620_abnormal_muscle_contractility | 2.66593786 |
| 18 | MP0006138_congestive_heart_failure | 2.50507135 |
| 19 | MP0004484_altered_response_of | 2.47769006 |
| 20 | MP0002106_abnormal_muscle_physiology | 2.43775559 |
| 21 | MP0004130_abnormal_muscle_cell | 2.39706654 |
| 22 | MP0003828_pulmonary_edema | 2.34143177 |
| 23 | MP0002269_muscular_atrophy | 2.26747720 |
| 24 | MP0004085_abnormal_heartbeat | 2.19052624 |
| 25 | MP0004510_myositis | 2.13982138 |
| 26 | MP0003221_abnormal_cardiomyocyte_apopto | 2.07180272 |
| 27 | MP0004145_abnormal_muscle_electrophysio | 1.98996176 |
| 28 | MP0005369_muscle_phenotype | 1.96777138 |
| 29 | MP0000759_abnormal_skeletal_muscle | 1.87493639 |
| 30 | MP0000747_muscle_weakness | 1.86374998 |
| 31 | MP0002127_abnormal_cardiovascular_syste | 1.76888443 |
| 32 | MP0003950_abnormal_plasma_membrane | 1.70789468 |
| 33 | MP0004233_abnormal_muscle_weight | 1.62413749 |
| 34 | MP0006036_abnormal_mitochondrial_physio | 1.61821090 |
| 35 | MP0005670_abnormal_white_adipose | 1.39484226 |
| 36 | MP0005666_abnormal_adipose_tissue | 1.38473117 |
| 37 | MP0002332_abnormal_exercise_endurance | 1.30699502 |
| 38 | MP0003567_abnormal_fetal_cardiomyocyte | 1.26963844 |
| 39 | MP0000343_altered_response_to | 1.18910847 |
| 40 | MP0010368_abnormal_lymphatic_system | 1.18463761 |
| 41 | MP0000266_abnormal_heart_morphology | 1.16091154 |
| 42 | MP0003279_aneurysm | 1.13253076 |
| 43 | MP0005165_increased_susceptibility_to | 1.09146572 |
| 44 | MP0001661_extended_life_span | 1.07961621 |
| 45 | MP0002234_abnormal_pharynx_morphology | 1.04647287 |
| 46 | MP0006035_abnormal_mitochondrial_morpho | 0.95323971 |
| 47 | MP0005375_adipose_tissue_phenotype | 0.92367044 |
| 48 | MP0004185_abnormal_adipocyte_glucose | 0.88898998 |
| 49 | MP0002128_abnormal_blood_circulation | 0.83191529 |
| 50 | MP0005623_abnormal_meninges_morphology | 0.81920444 |
| 51 | MP0000230_abnormal_systemic_arterial | 0.80393557 |
| 52 | MP0002108_abnormal_muscle_morphology | 0.78894234 |
| 53 | MP0005266_abnormal_metabolism | 0.77292113 |
| 54 | MP0003566_abnormal_cell_adhesion | 0.74533878 |
| 55 | MP0004270_analgesia | 0.69356924 |
| 56 | MP0000767_abnormal_smooth_muscle | 0.65642144 |
| 57 | MP0002909_abnormal_adrenal_gland | 0.64619037 |
| 58 | MP0001879_abnormal_lymphatic_vessel | 0.64393085 |
| 59 | MP0003705_abnormal_hypodermis_morpholog | 0.64335826 |
| 60 | MP0003806_abnormal_nucleotide_metabolis | 0.63100688 |
| 61 | MP0005451_abnormal_body_composition | 0.60548339 |
| 62 | MP0005187_abnormal_penis_morphology | 0.52154033 |
| 63 | MP0000003_abnormal_adipose_tissue | 0.51652423 |
| 64 | MP0000733_abnormal_muscle_development | 0.51478694 |
| 65 | MP0004043_abnormal_pH_regulation | 0.51043260 |
| 66 | MP0004272_abnormal_basement_membrane | 0.50265448 |
| 67 | MP0002925_abnormal_cardiovascular_devel | 0.46711369 |
| 68 | MP0005319_abnormal_enzyme/_coenzyme | 0.46664523 |
| 69 | MP0008438_abnormal_cutaneous_collagen | 0.46522544 |
| 70 | MP0004147_increased_porphyrin_level | 0.46131179 |
| 71 | MP0000013_abnormal_adipose_tissue | 0.45095017 |
| 72 | MP0002638_abnormal_pupillary_reflex | 0.43939541 |
| 73 | MP0002078_abnormal_glucose_homeostasis | 0.42431381 |
| 74 | MP0002971_abnormal_brown_adipose | 0.42215987 |
| 75 | MP0003984_embryonic_growth_retardation | 0.41396735 |
| 76 | MP0002088_abnormal_embryonic_growth/wei | 0.39955451 |
| 77 | MP0000372_irregular_coat_pigmentation | 0.37292185 |
| 78 | MP0001614_abnormal_blood_vessel | 0.36299678 |
| 79 | MP0001784_abnormal_fluid_regulation | 0.34866430 |
| 80 | MP0001299_abnormal_eye_distance/ | 0.34634639 |
| 81 | MP0008961_abnormal_basal_metabolism | 0.33620696 |
| 82 | MP0008569_lethality_at_weaning | 0.33346217 |
| 83 | MP0005275_abnormal_skin_tensile | 0.31764434 |
| 84 | MP0009384_cardiac_valve_regurgitation | 0.31191978 |
| 85 | MP0003045_fibrosis | 0.30943058 |
| 86 | MP0005535_abnormal_body_temperature | 0.30660638 |
| 87 | MP0003948_abnormal_gas_homeostasis | 0.29879002 |
| 88 | MP0005386_behavior/neurological_phenoty | 0.28875310 |
| 89 | MP0004924_abnormal_behavior | 0.28875310 |
| 90 | MP0005595_abnormal_vascular_smooth | 0.27788113 |
| 91 | MP0005376_homeostasis/metabolism_phenot | 0.27013375 |
| 92 | MP0004142_abnormal_muscle_tone | 0.26997538 |
| 93 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.25821331 |
| 94 | MP0005423_abnormal_somatic_nervous | 0.24905321 |
| 95 | MP0009840_abnormal_foam_cell | 0.24623401 |
| 96 | MP0002822_catalepsy | 0.24618014 |
| 97 | MP0001727_abnormal_embryo_implantation | 0.24382008 |
| 98 | MP0002734_abnormal_mechanical_nocicepti | 0.24077482 |
| 99 | MP0005334_abnormal_fat_pad | 0.23948360 |
| 100 | MP0003879_abnormal_hair_cell | 0.23427908 |
| 101 | MP0005452_abnormal_adipose_tissue | 0.22410661 |
| 102 | MP0005167_abnormal_blood-brain_barrier | 0.22293634 |
| 103 | MP0005332_abnormal_amino_acid | 0.22111568 |
| 104 | MP0001958_emphysema | 0.22000309 |
| 105 | MP0009780_abnormal_chondrocyte_physiolo | 0.21953547 |
| 106 | MP0002295_abnormal_pulmonary_circulatio | 0.21590916 |
| 107 | MP0000249_abnormal_blood_vessel | 0.21520394 |
| 108 | MP0002118_abnormal_lipid_homeostasis | 0.21505586 |
| 109 | MP0009115_abnormal_fat_cell | 0.20687698 |
| 110 | MP0001672_abnormal_embryogenesis/_devel | 0.20502716 |
| 111 | MP0005380_embryogenesis_phenotype | 0.20502716 |
| 112 | MP0005083_abnormal_biliary_tract | 0.20091737 |
| 113 | MP0008004_abnormal_stomach_pH | 0.20048467 |
| 114 | MP0003136_yellow_coat_color | 0.19278888 |
| 115 | MP0005388_respiratory_system_phenotype | 0.18947187 |
| 116 | MP0002133_abnormal_respiratory_system | 0.18947187 |
| 117 | MP0009250_abnormal_appendicular_skeleto | 0.18763249 |
| 118 | MP0001984_abnormal_olfaction | 0.17095317 |
| 119 | MP0000762_abnormal_tongue_morphology | 0.15579687 |
| 120 | MP0004134_abnormal_chest_morphology | 0.14395377 |
| 121 | MP0001986_abnormal_taste_sensitivity | 0.14347041 |
| 122 | MP0005503_abnormal_tendon_morphology | 0.13984509 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Sudden death (HP:0001699) | 8.60408727 |
| 2 | Nemaline bodies (HP:0003798) | 8.29344561 |
| 3 | Ventricular tachycardia (HP:0004756) | 7.40236315 |
| 4 | Calf muscle hypertrophy (HP:0008981) | 6.53821188 |
| 5 | Atrial fibrillation (HP:0005110) | 6.49726265 |
| 6 | Primary atrial arrhythmia (HP:0001692) | 6.08109502 |
| 7 | Muscle fiber splitting (HP:0003555) | 5.94875948 |
| 8 | Muscle hypertrophy of the lower extremities (HP:0008968) | 5.91250876 |
| 9 | Supraventricular tachycardia (HP:0004755) | 5.88324312 |
| 10 | Supraventricular arrhythmia (HP:0005115) | 5.76436739 |
| 11 | Lipoatrophy (HP:0100578) | 5.69595318 |
| 12 | Exercise-induced muscle cramps (HP:0003710) | 5.56551797 |
| 13 | Abnormality of the calf musculature (HP:0001430) | 5.48963258 |
| 14 | Exercise-induced myalgia (HP:0003738) | 5.39977568 |
| 15 | Right ventricular cardiomyopathy (HP:0011663) | 5.30671423 |
| 16 | Abnormality of the left ventricular outflow tract (HP:0011103) | 5.21384229 |
| 17 | Subaortic stenosis (HP:0001682) | 5.21384229 |
| 18 | Hyporeflexia of lower limbs (HP:0002600) | 5.14667054 |
| 19 | Syncope (HP:0001279) | 5.06345487 |
| 20 | Bundle branch block (HP:0011710) | 4.80817612 |
| 21 | Distal arthrogryposis (HP:0005684) | 4.77060588 |
| 22 | Dilated cardiomyopathy (HP:0001644) | 4.71101186 |
| 23 | Palpitations (HP:0001962) | 4.59092886 |
| 24 | Myoglobinuria (HP:0002913) | 4.50980676 |
| 25 | Prolonged QT interval (HP:0001657) | 4.50549437 |
| 26 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 4.41534831 |
| 27 | EMG: myopathic abnormalities (HP:0003458) | 4.31065518 |
| 28 | Ventricular arrhythmia (HP:0004308) | 4.20430467 |
| 29 | Myopathic facies (HP:0002058) | 4.19794873 |
| 30 | Asymmetric septal hypertrophy (HP:0001670) | 4.16343778 |
| 31 | Heart block (HP:0012722) | 3.99920961 |
| 32 | Increased connective tissue (HP:0009025) | 3.92908641 |
| 33 | Atrioventricular block (HP:0001678) | 3.86476642 |
| 34 | Round ear (HP:0100830) | 3.86116469 |
| 35 | Abnormal atrioventricular conduction (HP:0005150) | 3.77292816 |
| 36 | Ventricular fibrillation (HP:0001663) | 3.77051451 |
| 37 | Ulnar deviation of the wrist (HP:0003049) | 3.64157915 |
| 38 | Rhabdomyolysis (HP:0003201) | 3.41842738 |
| 39 | Difficulty running (HP:0009046) | 3.38266714 |
| 40 | Myotonia (HP:0002486) | 3.36371384 |
| 41 | Abnormal EKG (HP:0003115) | 3.24365824 |
| 42 | Left ventricular hypertrophy (HP:0001712) | 3.04922989 |
| 43 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.97982055 |
| 44 | Acute necrotizing encephalopathy (HP:0006965) | 2.96142711 |
| 45 | Hepatic necrosis (HP:0002605) | 2.93635906 |
| 46 | Calcaneovalgus deformity (HP:0001848) | 2.92432960 |
| 47 | Frequent falls (HP:0002359) | 2.92351542 |
| 48 | Difficulty climbing stairs (HP:0003551) | 2.91823913 |
| 49 | Palmoplantar keratoderma (HP:0000982) | 2.81310506 |
| 50 | Absent phalangeal crease (HP:0006109) | 2.78668569 |
| 51 | Ketoacidosis (HP:0001993) | 2.73331962 |
| 52 | Bulbar palsy (HP:0001283) | 2.70071575 |
| 53 | Lower limb amyotrophy (HP:0007210) | 2.68448043 |
| 54 | Distal lower limb muscle weakness (HP:0009053) | 2.65665358 |
| 55 | Malignant hyperthermia (HP:0002047) | 2.59901217 |
| 56 | Hypoglycemic coma (HP:0001325) | 2.57764724 |
| 57 | Deformed tarsal bones (HP:0008119) | 2.57544038 |
| 58 | Hepatocellular necrosis (HP:0001404) | 2.56256921 |
| 59 | Testicular atrophy (HP:0000029) | 2.56224404 |
| 60 | Acute encephalopathy (HP:0006846) | 2.54771318 |
| 61 | Areflexia of lower limbs (HP:0002522) | 2.45400498 |
| 62 | Progressive macrocephaly (HP:0004481) | 2.44171709 |
| 63 | Weak cry (HP:0001612) | 2.43292370 |
| 64 | Limb-girdle muscle atrophy (HP:0003797) | 2.42645026 |
| 65 | Mitochondrial inheritance (HP:0001427) | 2.41047573 |
| 66 | Increased variability in muscle fiber diameter (HP:0003557) | 2.40080497 |
| 67 | Progressive muscle weakness (HP:0003323) | 2.39937618 |
| 68 | Ragged-red muscle fibers (HP:0003200) | 2.39638887 |
| 69 | Neck muscle weakness (HP:0000467) | 2.39192861 |
| 70 | Cerebral edema (HP:0002181) | 2.35895080 |
| 71 | Increased muscle lipid content (HP:0009058) | 2.31450073 |
| 72 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.29674077 |
| 73 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.29302287 |
| 74 | Dicarboxylic aciduria (HP:0003215) | 2.29302287 |
| 75 | Type 1 muscle fiber predominance (HP:0003803) | 2.28659884 |
| 76 | Conjunctival hamartoma (HP:0100780) | 2.28370809 |
| 77 | Fetal akinesia sequence (HP:0001989) | 2.28029450 |
| 78 | Abnormality of the shoulder girdle musculature (HP:0001435) | 2.27910467 |
| 79 | Proximal amyotrophy (HP:0007126) | 2.27437915 |
| 80 | Increased CSF lactate (HP:0002490) | 2.26788691 |
| 81 | Abnormal finger flexion creases (HP:0006143) | 2.26191331 |
| 82 | Abnormality of the foot musculature (HP:0001436) | 2.22386207 |
| 83 | Muscle stiffness (HP:0003552) | 2.21790060 |
| 84 | Sudden cardiac death (HP:0001645) | 2.21730837 |
| 85 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.17632164 |
| 86 | Hip contracture (HP:0003273) | 2.16053475 |
| 87 | Fatigable weakness (HP:0003473) | 2.15489834 |
| 88 | Abnormality of the neuromuscular junction (HP:0003398) | 2.15489834 |
| 89 | Pheochromocytoma (HP:0002666) | 2.11435937 |
| 90 | Congestive heart failure (HP:0001635) | 2.08048032 |
| 91 | Distal lower limb amyotrophy (HP:0008944) | 2.07536997 |
| 92 | Exercise intolerance (HP:0003546) | 2.06704148 |
| 93 | Foot dorsiflexor weakness (HP:0009027) | 2.06482634 |
| 94 | Waddling gait (HP:0002515) | 2.05811521 |
| 95 | Respiratory failure (HP:0002878) | 2.05779567 |
| 96 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.03909311 |
| 97 | Dysmetric saccades (HP:0000641) | 2.03573402 |
| 98 | Lactic acidosis (HP:0003128) | 2.02571287 |
| 99 | Increased intramyocellular lipid droplets (HP:0012240) | 2.02158586 |
| 100 | Muscular dystrophy (HP:0003560) | 1.99689837 |
| 101 | Rimmed vacuoles (HP:0003805) | 1.99378342 |
| 102 | Ketosis (HP:0001946) | 1.99206169 |
| 103 | Hypoplastic ischia (HP:0003175) | 1.97398452 |
| 104 | EMG: neuropathic changes (HP:0003445) | 1.96203338 |
| 105 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.95283938 |
| 106 | Neoplasm of the adrenal gland (HP:0100631) | 1.92370592 |
| 107 | Large for gestational age (HP:0001520) | 1.91582991 |
| 108 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.91154870 |
| 109 | Hamartoma of the eye (HP:0010568) | 1.89756388 |
| 110 | Gowers sign (HP:0003391) | 1.88492023 |
| 111 | Neuroendocrine neoplasm (HP:0100634) | 1.88324730 |
| 112 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.86552399 |
| 113 | Neoplasm of head and neck (HP:0012288) | 1.85284782 |
| 114 | Esophageal neoplasm (HP:0100751) | 1.85284782 |
| 115 | Spinal rigidity (HP:0003306) | 1.85225484 |
| 116 | Muscle fiber inclusion bodies (HP:0100299) | 1.84443801 |
| 117 | Double outlet right ventricle (HP:0001719) | 1.83070673 |
| 118 | Congenital malformation of the right heart (HP:0011723) | 1.83070673 |
| 119 | Popliteal pterygium (HP:0009756) | 1.82936038 |
| 120 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.82128133 |
| 121 | Abnormality of alanine metabolism (HP:0010916) | 1.82128133 |
| 122 | Hyperalaninemia (HP:0003348) | 1.82128133 |
| 123 | Generalized muscle weakness (HP:0003324) | 1.81326913 |
| 124 | Steppage gait (HP:0003376) | 1.78670483 |
| 125 | Facial diplegia (HP:0001349) | 1.78166202 |
| 126 | Scapular winging (HP:0003691) | 1.78011337 |
| 127 | Central scotoma (HP:0000603) | 1.73156064 |
| 128 | Hyperkalemia (HP:0002153) | 1.71199079 |
| 129 | Type 2 muscle fiber atrophy (HP:0003554) | 1.71052243 |
| 130 | Aplasia of the musculature (HP:0100854) | 1.66652842 |
| 131 | Muscle fiber atrophy (HP:0100295) | 1.55609709 |
| 132 | Hypoplastic heart (HP:0001961) | 1.53328375 |
| 133 | Slender build (HP:0001533) | 1.52684105 |
| 134 | Abnormality of the calcaneus (HP:0008364) | 1.49471100 |
| 135 | Limited hip movement (HP:0008800) | 1.45609154 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TTN | 5.93916623 |
| 2 | OBSCN | 4.66033476 |
| 3 | LMTK2 | 4.16183676 |
| 4 | MYLK | 4.06435449 |
| 5 | PHKG2 | 3.90482563 |
| 6 | PHKG1 | 3.90482563 |
| 7 | PDK3 | 3.32012677 |
| 8 | PDK4 | 3.32012677 |
| 9 | DMPK | 3.28181748 |
| 10 | PKN2 | 2.98887813 |
| 11 | MUSK | 2.58172735 |
| 12 | TRIB3 | 2.47372644 |
| 13 | BCKDK | 2.39702267 |
| 14 | PIK3CA | 2.34816342 |
| 15 | TIE1 | 2.16810598 |
| 16 | PIK3CG | 2.13463826 |
| 17 | NEK1 | 2.11330319 |
| 18 | PDK2 | 1.97685941 |
| 19 | PINK1 | 1.88686673 |
| 20 | STK24 | 1.78927609 |
| 21 | GRK7 | 1.54522300 |
| 22 | PAK3 | 1.53082722 |
| 23 | PRKD1 | 1.41938227 |
| 24 | CAMK2D | 1.39403519 |
| 25 | CDC42BPA | 1.27609218 |
| 26 | ZAK | 1.27235254 |
| 27 | ILK | 1.20019507 |
| 28 | MARK1 | 1.17185723 |
| 29 | LIMK1 | 1.14780759 |
| 30 | ROCK1 | 1.12174864 |
| 31 | STK4 | 1.09871493 |
| 32 | INSRR | 1.01833686 |
| 33 | WNK4 | 1.00903935 |
| 34 | PKN1 | 0.98352243 |
| 35 | DAPK3 | 0.97162840 |
| 36 | EEF2K | 0.95957889 |
| 37 | RIPK1 | 0.94299634 |
| 38 | MAP3K7 | 0.94265554 |
| 39 | MAPK12 | 0.94142539 |
| 40 | STK38L | 0.92359451 |
| 41 | MAP3K5 | 0.92080830 |
| 42 | MAPKAPK3 | 0.91310937 |
| 43 | PRKAA1 | 0.86233822 |
| 44 | FLT3 | 0.83582185 |
| 45 | TRPM7 | 0.82588969 |
| 46 | MOS | 0.82276341 |
| 47 | PRKAA2 | 0.80129482 |
| 48 | PDGFRA | 0.75793192 |
| 49 | CAMK4 | 0.75780169 |
| 50 | ROCK2 | 0.69073630 |
| 51 | STK38 | 0.68456037 |
| 52 | MAP2K3 | 0.67625092 |
| 53 | MAP2K1 | 0.65554895 |
| 54 | RPS6KC1 | 0.65200414 |
| 55 | RPS6KL1 | 0.65200414 |
| 56 | KDR | 0.64214030 |
| 57 | CAMK2A | 0.63243659 |
| 58 | MAP3K3 | 0.61968705 |
| 59 | WNK1 | 0.61902290 |
| 60 | EPHB1 | 0.61824280 |
| 61 | MAP2K4 | 0.61180746 |
| 62 | CCNB1 | 0.58968127 |
| 63 | PTK2B | 0.57876162 |
| 64 | MARK3 | 0.56175128 |
| 65 | RPS6KA6 | 0.56073763 |
| 66 | TGFBR2 | 0.55596686 |
| 67 | CAMK1 | 0.54486876 |
| 68 | MAPK4 | 0.54356224 |
| 69 | PRKACB | 0.53123848 |
| 70 | PRKCE | 0.50102421 |
| 71 | CAMK2B | 0.47943497 |
| 72 | MAP2K6 | 0.44726832 |
| 73 | MAP3K6 | 0.43095705 |
| 74 | ICK | 0.42910321 |
| 75 | PRKACG | 0.41792782 |
| 76 | SIK1 | 0.41771550 |
| 77 | PRKACA | 0.41588463 |
| 78 | MAP3K1 | 0.40307457 |
| 79 | AKT2 | 0.35781634 |
| 80 | MAP3K13 | 0.35206730 |
| 81 | PRKD3 | 0.34655776 |
| 82 | STK39 | 0.34185928 |
| 83 | PDPK1 | 0.33674911 |
| 84 | PRKCH | 0.33532844 |
| 85 | PTK6 | 0.30991543 |
| 86 | NEK9 | 0.30826422 |
| 87 | CAMK2G | 0.30221327 |
| 88 | KSR2 | 0.28386494 |
| 89 | ERBB3 | 0.28372843 |
| 90 | DYRK1B | 0.27692005 |
| 91 | RPS6KB2 | 0.27311087 |
| 92 | PDK1 | 0.26932574 |
| 93 | SGK2 | 0.26673367 |
| 94 | RPS6KA1 | 0.26598206 |
| 95 | EPHB2 | 0.24834355 |
| 96 | NME1 | 0.23709426 |
| 97 | MTOR | 0.22954324 |
| 98 | NME2 | 0.22415441 |
| 99 | PRKG2 | 0.22122265 |
| 100 | JAK1 | 0.21866723 |
| 101 | SGK3 | 0.21673754 |
| 102 | ARAF | 0.21384746 |
| 103 | LATS2 | 0.21014713 |
| 104 | PRKG1 | 0.20691613 |
| 105 | FER | 0.19775132 |
| 106 | RPS6KB1 | 0.18864114 |
| 107 | STK11 | 0.18597759 |
| 108 | RET | 0.17902339 |
| 109 | LATS1 | 0.16306439 |
| 110 | RPS6KA2 | 0.15996363 |
| 111 | MAPK10 | 0.15069577 |
| 112 | RPS6KA3 | 0.14925419 |
| 113 | PDGFRB | 0.13965274 |
| 114 | SGK1 | 0.13824891 |
| 115 | FGFR4 | 0.13617377 |
| 116 | SGK223 | 0.12889155 |
| 117 | SGK494 | 0.12889155 |
| 118 | LRRK2 | 0.10757000 |
| 119 | MAP3K9 | 0.10287274 |
| 120 | MAPK7 | 0.09518009 |
| 121 | NLK | 0.08917055 |
| 122 | MAPKAPK2 | 0.08794129 |
| 123 | EPHA3 | 0.08657398 |
| 124 | MAPK11 | 0.08489110 |
| 125 | PAK6 | 0.08338191 |
| 126 | CAMK1D | 0.07788622 |
| 127 | MAP3K10 | 0.07429003 |
| 128 | TAOK1 | 0.07078173 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 5.78408371 |
| 2 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 4.54593187 |
| 3 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 4.22501066 |
| 4 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.99806463 |
| 5 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.88839566 |
| 6 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.38937060 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 3.26920947 |
| 8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.20241400 |
| 9 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.16623127 |
| 10 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.77643862 |
| 11 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.52474892 |
| 12 | Alzheimers disease_Homo sapiens_hsa05010 | 2.41581794 |
| 13 | Carbon metabolism_Homo sapiens_hsa01200 | 2.40781854 |
| 14 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.22412105 |
| 15 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.21548110 |
| 16 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.10160758 |
| 17 | Huntingtons disease_Homo sapiens_hsa05016 | 2.04881652 |
| 18 | Viral myocarditis_Homo sapiens_hsa05416 | 1.93243347 |
| 19 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.82682219 |
| 20 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.76348613 |
| 21 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.42266693 |
| 22 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.38632664 |
| 23 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.21939154 |
| 24 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.16924316 |
| 25 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.16073900 |
| 26 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.10111917 |
| 27 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.08438896 |
| 28 | Insulin resistance_Homo sapiens_hsa04931 | 1.02816927 |
| 29 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.00805024 |
| 30 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.95497268 |
| 31 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.94484987 |
| 32 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.94435869 |
| 33 | Lysine degradation_Homo sapiens_hsa00310 | 0.85084106 |
| 34 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.84600487 |
| 35 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.83809604 |
| 36 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.83042766 |
| 37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.79165060 |
| 38 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.75053146 |
| 39 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.73654969 |
| 40 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.72937055 |
| 41 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.72799746 |
| 42 | Focal adhesion_Homo sapiens_hsa04510 | 0.71080125 |
| 43 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.70745410 |
| 44 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.69746567 |
| 45 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.68810574 |
| 46 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.64027834 |
| 47 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.63367227 |
| 48 | Salivary secretion_Homo sapiens_hsa04970 | 0.60650414 |
| 49 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.58746776 |
| 50 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.58500815 |
| 51 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.57054679 |
| 52 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.55879484 |
| 53 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.55412166 |
| 54 | Tight junction_Homo sapiens_hsa04530 | 0.54571110 |
| 55 | Galactose metabolism_Homo sapiens_hsa00052 | 0.51471206 |
| 56 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.51346056 |
| 57 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.49123375 |
| 58 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.47550587 |
| 59 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.47267223 |
| 60 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.47077766 |
| 61 | Sulfur relay system_Homo sapiens_hsa04122 | 0.45962277 |
| 62 | Peroxisome_Homo sapiens_hsa04146 | 0.45754633 |
| 63 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.45131985 |
| 64 | Mineral absorption_Homo sapiens_hsa04978 | 0.44048859 |
| 65 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.43921217 |
| 66 | Renin secretion_Homo sapiens_hsa04924 | 0.43371766 |
| 67 | Olfactory transduction_Homo sapiens_hsa04740 | 0.40386078 |
| 68 | Insulin secretion_Homo sapiens_hsa04911 | 0.39340193 |
| 69 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.38804337 |
| 70 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.37324064 |
| 71 | Long-term potentiation_Homo sapiens_hsa04720 | 0.36872520 |
| 72 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.36292481 |
| 73 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.36286709 |
| 74 | Adherens junction_Homo sapiens_hsa04520 | 0.36038362 |
| 75 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.34504175 |
| 76 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.34439412 |
| 77 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.33817076 |
| 78 | Amoebiasis_Homo sapiens_hsa05146 | 0.31473265 |
| 79 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.31373039 |
| 80 | Circadian entrainment_Homo sapiens_hsa04713 | 0.26370936 |
| 81 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.26194903 |
| 82 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.24113405 |
| 83 | Metabolic pathways_Homo sapiens_hsa01100 | 0.23902534 |
| 84 | Melanogenesis_Homo sapiens_hsa04916 | 0.23848537 |
| 85 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.23543710 |
| 86 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.21040613 |
| 87 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.20799650 |
| 88 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.19275049 |
| 89 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.18386007 |
| 90 | Circadian rhythm_Homo sapiens_hsa04710 | 0.18378989 |
| 91 | GABAergic synapse_Homo sapiens_hsa04727 | 0.18315929 |
| 92 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.18270950 |
| 93 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.16324397 |
| 94 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.15330752 |
| 95 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.15234606 |
| 96 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.14277150 |
| 97 | Purine metabolism_Homo sapiens_hsa00230 | 0.14251449 |
| 98 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.13964858 |
| 99 | Platelet activation_Homo sapiens_hsa04611 | 0.13118988 |
| 100 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.13054034 |
| 101 | Morphine addiction_Homo sapiens_hsa05032 | 0.11924712 |
| 102 | Taste transduction_Homo sapiens_hsa04742 | 0.11227993 |
| 103 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.11172819 |
| 104 | Gap junction_Homo sapiens_hsa04540 | 0.10858382 |
| 105 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.10419224 |
| 106 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.10072783 |
| 107 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.09588535 |
| 108 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.09325728 |
| 109 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.08911735 |
| 110 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.08572815 |
| 111 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.08241770 |
| 112 | Bile secretion_Homo sapiens_hsa04976 | 0.07132630 |
| 113 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.06366284 |
| 114 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.04294421 |
| 115 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.02030749 |
| 116 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.02027821 |
| 117 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.01391780 |
| 118 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.01282281 |
| 119 | Estrogen signaling pathway_Homo sapiens_hsa04915 | -0.0191816 |
| 120 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | -0.0162735 |
| 121 | FoxO signaling pathway_Homo sapiens_hsa04068 | -0.0132110 |

