ADPRHL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.62829375
2DNA deamination (GO:0045006)6.21827209
3viral transcription (GO:0019083)6.18754431
4translational termination (GO:0006415)5.95251342
5ribosomal small subunit biogenesis (GO:0042274)5.32466921
6translational elongation (GO:0006414)5.31071473
7maturation of SSU-rRNA (GO:0030490)5.24332023
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.05401648
9protein targeting to ER (GO:0045047)4.90027009
10cotranslational protein targeting to membrane (GO:0006613)4.89606880
11nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.89326876
12DNA strand elongation involved in DNA replication (GO:0006271)4.86611422
13translational initiation (GO:0006413)4.77120778
14telomere maintenance via semi-conservative replication (GO:0032201)4.71755088
15viral life cycle (GO:0019058)4.70710989
16establishment of protein localization to endoplasmic reticulum (GO:0072599)4.64635125
17DNA strand elongation (GO:0022616)4.62901267
18protein localization to endoplasmic reticulum (GO:0070972)4.62737728
19cellular protein complex disassembly (GO:0043624)4.59449531
20negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.26583593
21DNA unwinding involved in DNA replication (GO:0006268)4.20966203
22DNA replication initiation (GO:0006270)4.18618521
23protein complex disassembly (GO:0043241)4.17098485
24ribosomal large subunit biogenesis (GO:0042273)4.14026990
25ribonucleoprotein complex biogenesis (GO:0022613)4.12539682
26Golgi transport vesicle coating (GO:0048200)4.01578359
27COPI coating of Golgi vesicle (GO:0048205)4.01578359
28telomere maintenance via recombination (GO:0000722)3.99428601
29formation of translation preinitiation complex (GO:0001731)3.95873331
30macromolecular complex disassembly (GO:0032984)3.92028828
31NIK/NF-kappaB signaling (GO:0038061)3.85205405
32nucleobase biosynthetic process (GO:0046112)3.84973112
33negative regulation of myeloid cell apoptotic process (GO:0033033)3.84641079
34peptidyl-arginine omega-N-methylation (GO:0035247)3.81205797
35establishment of viral latency (GO:0019043)3.76369764
36ribosome biogenesis (GO:0042254)3.76236770
37rRNA modification (GO:0000154)3.74930980
38nuclear-transcribed mRNA catabolic process (GO:0000956)3.74444397
39pseudouridine synthesis (GO:0001522)3.74407099
40folic acid-containing compound biosynthetic process (GO:0009396)3.74401766
41mitotic recombination (GO:0006312)3.62127862
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.59008037
43purine nucleobase biosynthetic process (GO:0009113)3.58479672
44mRNA catabolic process (GO:0006402)3.57176897
45nuclear envelope reassembly (GO:0031468)3.56370103
46mitotic nuclear envelope reassembly (GO:0007084)3.56370103
47telomere maintenance via telomere lengthening (GO:0010833)3.55049949
48protein maturation by protein folding (GO:0022417)3.54050567
49regulation of chronic inflammatory response (GO:0002676)3.53913361
50rRNA processing (GO:0006364)3.53533617
51translation (GO:0006412)3.52560202
52RNA catabolic process (GO:0006401)3.45965088
53rRNA metabolic process (GO:0016072)3.38895662
54proteasome assembly (GO:0043248)3.34604743
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.34343901
56positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.29627221
57positive regulation of chemokine biosynthetic process (GO:0045080)3.28990330
58negative regulation of RNA splicing (GO:0033119)3.27956328
59lipopolysaccharide biosynthetic process (GO:0009103)3.27623383
60nucleotide-excision repair, DNA gap filling (GO:0006297)3.25991406
61protein targeting to membrane (GO:0006612)3.24262996
62folic acid metabolic process (GO:0046655)3.23835661
63IMP biosynthetic process (GO:0006188)3.23231542
64negative regulation of erythrocyte differentiation (GO:0045647)3.22248314
65regulation of vitamin D biosynthetic process (GO:0060556)3.20491571
66peptidyl-arginine methylation (GO:0018216)3.20287097
67peptidyl-arginine N-methylation (GO:0035246)3.20287097
68iron-sulfur cluster assembly (GO:0016226)3.19899443
69metallo-sulfur cluster assembly (GO:0031163)3.19899443
70rRNA methylation (GO:0031167)3.19819617
71activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.19405310
72spliceosomal snRNP assembly (GO:0000387)3.18952432
73cellular component biogenesis (GO:0044085)3.16971666
74amino sugar catabolic process (GO:0046348)3.15083638
75protein localization to kinetochore (GO:0034501)3.13878038
76positive regulation of natural killer cell differentiation (GO:0032825)3.13675360
77lipopolysaccharide metabolic process (GO:0008653)3.11426530
78regulation of podosome assembly (GO:0071801)3.11176767
79histone arginine methylation (GO:0034969)3.10249941
80DNA replication checkpoint (GO:0000076)3.09221593
81DNA replication-dependent nucleosome assembly (GO:0006335)3.06503574
82DNA replication-dependent nucleosome organization (GO:0034723)3.06503574
83GDP-mannose metabolic process (GO:0019673)3.04774070
84negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.03752302
85tRNA methylation (GO:0030488)2.99663023
86type I interferon signaling pathway (GO:0060337)2.98702104
87cellular response to type I interferon (GO:0071357)2.98702104
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98029089
89regulation of chemokine biosynthetic process (GO:0045073)2.96532593
90mitotic nuclear envelope disassembly (GO:0007077)2.95906792
91natural killer cell mediated immunity (GO:0002228)2.95068894
92natural killer cell mediated cytotoxicity (GO:0042267)2.95068894
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94986317
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.92263233
95antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.92263233
96negative regulation of interleukin-12 production (GO:0032695)2.90410711
97response to peptidoglycan (GO:0032494)2.89099443
98pteridine-containing compound biosynthetic process (GO:0042559)2.87067934
99response to type I interferon (GO:0034340)2.86321238
100N-acetylneuraminate metabolic process (GO:0006054)2.85323590
101translesion synthesis (GO:0019985)2.84157156
102transcription-coupled nucleotide-excision repair (GO:0006283)2.83574615
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.83398330
104ribosome assembly (GO:0042255)2.82370002
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81825031
106regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81589077
107anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81388309
108pentose-phosphate shunt (GO:0006098)2.81203353
109de novo posttranslational protein folding (GO:0051084)2.80017849
110chaperone-mediated protein transport (GO:0072321)2.78569238
111regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.78122159
112IMP metabolic process (GO:0046040)2.77806707
113positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77091390
114antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.77052693
115spliceosomal complex assembly (GO:0000245)2.76064114
116DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74574955
117deoxyribose phosphate biosynthetic process (GO:0046385)2.74444179
1182-deoxyribonucleotide biosynthetic process (GO:0009265)2.74444179
119ncRNA 3-end processing (GO:0043628)2.74136965
120negative regulation of nitric oxide biosynthetic process (GO:0045019)2.74067129
121protein localization to chromosome, centromeric region (GO:0071459)2.73098758
122mRNA splicing, via spliceosome (GO:0000398)2.73053820
123RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.73053820
124regulation of cellular amino acid metabolic process (GO:0006521)2.72926552
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72404803
126negative regulation of mRNA processing (GO:0050686)2.72345466
127positive regulation of interleukin-17 production (GO:0032740)2.71956835
128regulation of interferon-gamma biosynthetic process (GO:0045072)2.71092240
129regulation of cytokine secretion involved in immune response (GO:0002739)2.70577018
130nuclear envelope disassembly (GO:0051081)2.70366050
131membrane disassembly (GO:0030397)2.70366050
132telomere organization (GO:0032200)2.69903538
133cellular response to interferon-beta (GO:0035458)2.69734658
134RNA splicing, via transesterification reactions (GO:0000375)2.69686905
135regulation of mitochondrial translation (GO:0070129)2.69457788
136negative regulation of ligase activity (GO:0051352)2.69125431
137negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69125431
138telomere maintenance (GO:0000723)2.69021532
139endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.69008927
140de novo protein folding (GO:0006458)2.66783594
141CENP-A containing nucleosome assembly (GO:0034080)2.65151553
142DNA replication-independent nucleosome organization (GO:0034724)2.64615822
143DNA replication-independent nucleosome assembly (GO:0006336)2.64615822
144signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63952539
145intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63952539
146guanosine-containing compound biosynthetic process (GO:1901070)2.61653356
147positive regulation of mitochondrial fission (GO:0090141)2.61467807
148maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61457350
149positive regulation of interleukin-10 production (GO:0032733)2.61232049
150peptidyl-histidine modification (GO:0018202)2.60196153
151establishment of integrated proviral latency (GO:0075713)2.60034994
152ncRNA processing (GO:0034470)2.59892078
153chromatin remodeling at centromere (GO:0031055)2.59832570
154RNA methylation (GO:0001510)2.59214295
155antigen processing and presentation via MHC class Ib (GO:0002475)2.58601182
156G1/S transition of mitotic cell cycle (GO:0000082)2.58280893
157protein deneddylation (GO:0000338)2.57074510
158signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56663546
159signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.56663546
160signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56663546
161immunoglobulin mediated immune response (GO:0016064)2.55773661
162chaperone mediated protein folding requiring cofactor (GO:0051085)2.55442458
163spliceosomal tri-snRNP complex assembly (GO:0000244)2.55429152
164negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.55104825
165negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.52799899
166protein targeting to mitochondrion (GO:0006626)2.52217086
167signal transduction involved in cell cycle checkpoint (GO:0072395)2.50412216
168pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.49492819
169DNA damage response, detection of DNA damage (GO:0042769)2.49416522
170signal transduction involved in DNA damage checkpoint (GO:0072422)2.48846528
171signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48846528
172regulation of translation in response to stress (GO:0043555)2.47865147
173positive regulation of lymphocyte apoptotic process (GO:0070230)2.46555889
174cullin deneddylation (GO:0010388)2.46507954
175response to interferon-beta (GO:0035456)2.46147844
176axonemal dynein complex assembly (GO:0070286)2.45495529
177positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.43591182
178cellular response to virus (GO:0098586)2.42373530
179base-excision repair, AP site formation (GO:0006285)2.42196930
180regulation of release of cytochrome c from mitochondria (GO:0090199)2.38507543
181positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.36704006
182GTP biosynthetic process (GO:0006183)2.36432566
183positive regulation of ligase activity (GO:0051351)2.36084864
184purine nucleotide salvage (GO:0032261)2.35482802
185negative regulation of protein ubiquitination (GO:0031397)2.35153395
186activation of MAPKKK activity (GO:0000185)2.34813037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.32710045
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07474131
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.06667362
4* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78684477
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74554940
6* ETS1_20019798_ChIP-Seq_JURKAT_Human2.59422288
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56237735
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.55757407
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49930997
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48441060
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.39952177
12XRN2_22483619_ChIP-Seq_HELA_Human2.39918357
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39546872
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35352509
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33767322
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.32967997
17MYC_22102868_ChIP-Seq_BL_Human2.24728259
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24657098
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23207991
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10510138
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07569030
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03961333
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03223842
24* VDR_23849224_ChIP-Seq_CD4+_Human1.99250094
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96654959
26VDR_21846776_ChIP-Seq_THP-1_Human1.95225270
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94242489
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.93567885
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.79313460
30GABP_19822575_ChIP-Seq_HepG2_Human1.75064927
31* CIITA_25753668_ChIP-Seq_RAJI_Human1.72892342
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67653883
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66234920
34TTF2_22483619_ChIP-Seq_HELA_Human1.65494029
35DCP1A_22483619_ChIP-Seq_HELA_Human1.64318640
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63639924
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61879082
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61469346
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59823368
40* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56835494
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55946211
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53495451
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.51978905
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51577405
45* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49598681
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48468707
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47787171
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47746070
49SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.46571572
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43720374
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42690209
52* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42034057
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.40580481
54AR_21909140_ChIP-Seq_LNCAP_Human1.40002158
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.39755797
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39399357
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38399555
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38391954
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34057949
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.33857166
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.33063913
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33060525
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31989766
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31628188
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.31262073
66GATA1_22025678_ChIP-Seq_K562_Human1.31000027
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.30729356
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29091530
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28849132
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27738650
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27557565
72KDM5A_27292631_Chip-Seq_BREAST_Human1.26784743
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26124220
74ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24870458
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.24418624
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23361644
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19450436
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19283207
79BCL6_27268052_Chip-Seq_Bcells_Human1.18900570
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18887371
81LXR_22292898_ChIP-Seq_THP-1_Human1.18608936
82SCL_19346495_ChIP-Seq_HPC-7_Human1.18393339
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17825522
84* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16726721
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16417712
86* SPI1_23547873_ChIP-Seq_NB4_Human1.16230747
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15875957
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15519964
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.15363554
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12394468
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12031169
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11637559
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10046254
94MAF_26560356_Chip-Seq_TH1_Human1.07518020
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07310503
96* UTX_26944678_Chip-Seq_JUKART_Human1.07076735
97TFEB_21752829_ChIP-Seq_HELA_Human1.05035158
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04668331
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.04232498
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03584223
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03522403
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03371980
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03359521
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02969836
105MAF_26560356_Chip-Seq_TH2_Human1.02898104
106* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02773956
107NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01767492
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00710755
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00353767
110* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98617543
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97883848
112ELK1_19687146_ChIP-ChIP_HELA_Human0.97322101
113* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96817871
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96801043
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96640383
116ZNF263_19887448_ChIP-Seq_K562_Human0.96342641
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94921882
118IRF8_22096565_ChIP-ChIP_GC-B_Human0.94858142
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94704540
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94379602
121TCF7_22412390_ChIP-Seq_EML_Mouse0.94099397
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91232477
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.90743949
124IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90106413
125* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90028778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.82584642
2MP0003303_peritoneal_inflammation4.16543966
3MP0008260_abnormal_autophagy3.82487848
4MP0004957_abnormal_blastocyst_morpholog3.79722433
5MP0005058_abnormal_lysosome_morphology3.59229800
6MP0003111_abnormal_nucleus_morphology3.53512034
7MP0010094_abnormal_chromosome_stability3.51416324
8MP0002396_abnormal_hematopoietic_system3.50943139
9MP0003077_abnormal_cell_cycle3.27893575
10MP0006082_CNS_inflammation2.86864670
11MP0008057_abnormal_DNA_replication2.77072901
12MP0002148_abnormal_hypersensitivity_rea2.58206839
13MP0004510_myositis2.54069701
14MP0008007_abnormal_cellular_replicative2.51685392
15MP0005451_abnormal_body_composition2.42587836
16MP0003763_abnormal_thymus_physiology2.39607573
17MP0009379_abnormal_foot_pigmentation2.28805660
18MP0008058_abnormal_DNA_repair2.28603615
19MP0000343_altered_response_to2.26905048
20MP0002332_abnormal_exercise_endurance2.25199719
21MP0003724_increased_susceptibility_to2.24218584
22MP0005397_hematopoietic_system_phenotyp2.24022894
23MP0001545_abnormal_hematopoietic_system2.24022894
24MP0009333_abnormal_splenocyte_physiolog2.13159725
25MP0000490_abnormal_crypts_of2.10868218
26MP0005387_immune_system_phenotype2.02172373
27MP0001790_abnormal_immune_system2.02172373
28MP0004808_abnormal_hematopoietic_stem1.99046320
29MP0001730_embryonic_growth_arrest1.92333995
30MP0010352_gastrointestinal_tract_polyps1.92153566
31MP0002419_abnormal_innate_immunity1.89890555
32MP0009840_abnormal_foam_cell1.86566914
33MP0003806_abnormal_nucleotide_metabolis1.85606800
34MP0003221_abnormal_cardiomyocyte_apopto1.84215835
35MP0002398_abnormal_bone_marrow1.82385693
36MP0009764_decreased_sensitivity_to1.81189705
37MP0000350_abnormal_cell_proliferation1.79359649
38MP0003075_altered_response_to1.78703971
39MP0000685_abnormal_immune_system1.69458008
40MP0008932_abnormal_embryonic_tissue1.69293035
41MP0002722_abnormal_immune_system1.69286194
42MP0000689_abnormal_spleen_morphology1.69074786
43MP0002019_abnormal_tumor_incidence1.69070772
44MP0001835_abnormal_antigen_presentation1.67304418
45MP0002254_reproductive_system_inflammat1.63745976
46MP0000313_abnormal_cell_death1.56702418
47MP0001542_abnormal_bone_strength1.55741889
48MP0002429_abnormal_blood_cell1.52638073
49MP0000750_abnormal_muscle_regeneration1.51942807
50MP0000703_abnormal_thymus_morphology1.50347031
51MP0002080_prenatal_lethality1.47419896
52MP0005075_abnormal_melanosome_morpholog1.44261333
53MP0005464_abnormal_platelet_physiology1.42009981
54MP0003453_abnormal_keratinocyte_physiol1.41989668
55MP0000716_abnormal_immune_system1.38906658
56MP0002132_abnormal_respiratory_system1.38703625
57MP0001697_abnormal_embryo_size1.37569453
58MP0001727_abnormal_embryo_implantation1.35786645
59MP0001800_abnormal_humoral_immune1.35379637
60MP0005671_abnormal_response_to1.32426629
61MP0000465_gastrointestinal_hemorrhage1.32022179
62MP0001533_abnormal_skeleton_physiology1.28604472
63MP0002420_abnormal_adaptive_immunity1.23374031
64MP0001819_abnormal_immune_cell1.22366358
65MP0000358_abnormal_cell_content/1.22093515
66MP0006036_abnormal_mitochondrial_physio1.21128267
67MP0002166_altered_tumor_susceptibility1.21036278
68MP0003786_premature_aging1.20434437
69MP0002452_abnormal_antigen_presenting1.20136970
70MP0001672_abnormal_embryogenesis/_devel1.16686036
71MP0005380_embryogenesis_phenotype1.16686036
72MP0003123_paternal_imprinting1.15921260
73MP0002723_abnormal_immune_serum1.15842220
74MP0000604_amyloidosis1.13616269
75MP0001853_heart_inflammation1.12999192
76MP0005257_abnormal_intraocular_pressure1.12384524
77MP0003646_muscle_fatigue1.11841058
78MP0003567_abnormal_fetal_cardiomyocyte1.10827689
79MP0001243_abnormal_dermal_layer1.10498100
80MP0000751_myopathy1.10485198
81MP0005025_abnormal_response_to1.09833250
82MP0002086_abnormal_extraembryonic_tissu1.08946701
83MP0000858_altered_metastatic_potential1.08869204
84MP0002405_respiratory_system_inflammati1.06670206
85MP0004233_abnormal_muscle_weight1.06401515
86MP0003436_decreased_susceptibility_to1.05764858
87MP0001873_stomach_inflammation1.05130276
88MP0009278_abnormal_bone_marrow1.03326171
89MP0005501_abnormal_skin_physiology1.02930770
90MP0008789_abnormal_olfactory_epithelium1.02920519
91MP0003984_embryonic_growth_retardation1.02468194
92MP0003186_abnormal_redox_activity1.02307481
93MP0002102_abnormal_ear_morphology1.01776990
94MP0002088_abnormal_embryonic_growth/wei1.01299854
95MP0010155_abnormal_intestine_physiology1.00931493
96MP0002085_abnormal_embryonic_tissue0.98997371
97MP0005023_abnormal_wound_healing0.98498834
98MP0000477_abnormal_intestine_morphology0.98186667
99MP0009785_altered_susceptibility_to0.98182105
100MP0003866_abnormal_defecation0.96573410
101MP0003172_abnormal_lysosome_physiology0.95929232
102MP0006054_spinal_hemorrhage0.93196981
103MP0005165_increased_susceptibility_to0.92920006
104MP0000749_muscle_degeneration0.92899473
105MP0005310_abnormal_salivary_gland0.91566931
106MP0005000_abnormal_immune_tolerance0.91522940
107MP0002084_abnormal_developmental_patter0.89957807
108MP0004197_abnormal_fetal_growth/weight/0.89734421
109MP0002006_tumorigenesis0.89187640
110MP0008004_abnormal_stomach_pH0.89176564
111MP0005166_decreased_susceptibility_to0.88101811
112MP0001293_anophthalmia0.87514543
113MP0002277_abnormal_respiratory_mucosa0.87092457
114MP0005174_abnormal_tail_pigmentation0.87021580
115MP0005167_abnormal_blood-brain_barrier0.85862772
116MP0002089_abnormal_postnatal_growth/wei0.85401592
117MP0000598_abnormal_liver_morphology0.85258705
118MP0006035_abnormal_mitochondrial_morpho0.85234284
119MP0010307_abnormal_tumor_latency0.85139984
120MP0005384_cellular_phenotype0.82573745
121MP0000747_muscle_weakness0.82235090
122MP0009763_increased_sensitivity_to0.80669830
123MP0005248_abnormal_Harderian_gland0.80329666
124MP0002095_abnormal_skin_pigmentation0.80292854
125MP0003656_abnormal_erythrocyte_physiolo0.80080689
126MP0001216_abnormal_epidermal_layer0.80060099
127MP0008874_decreased_physiological_sensi0.79965677
128MP0003329_amyloid_beta_deposits0.79096858
129MP0001764_abnormal_homeostasis0.77930489
130MP0010030_abnormal_orbit_morphology0.77759385
131MP0001845_abnormal_inflammatory_respons0.76449789
132MP0002837_dystrophic_cardiac_calcinosis0.75330958
133MP0003191_abnormal_cellular_cholesterol0.74883144
134MP0003718_maternal_effect0.72430778
135MP0001915_intracranial_hemorrhage0.72317781
136MP0006292_abnormal_olfactory_placode0.71669267
137MP0005220_abnormal_exocrine_pancreas0.68561084
138MP0002653_abnormal_ependyma_morphology0.68264777
139MP0001849_ear_inflammation0.68215419
140MP0003119_abnormal_digestive_system0.67144468
141MP0005266_abnormal_metabolism0.66654617
142MP0005319_abnormal_enzyme/_coenzyme0.66537529
143MP0008770_decreased_survivor_rate0.66266115
144MP0003566_abnormal_cell_adhesion0.65747853
145MP0008469_abnormal_protein_level0.65286268
146MP0004947_skin_inflammation0.65032056
147MP0009931_abnormal_skin_appearance0.64773867
148MP0000609_abnormal_liver_physiology0.64689016
149MP0002970_abnormal_white_adipose0.63622431

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.12178763
2Abnormal number of erythroid precursors (HP:0012131)5.77322415
3Reticulocytopenia (HP:0001896)5.18460886
4Aplastic anemia (HP:0001915)4.79144037
5Abnormality of liposaccharide metabolism (HP:0010968)4.57927935
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.57927935
7Abnormality of glycolipid metabolism (HP:0010969)4.57927935
8Oral leukoplakia (HP:0002745)4.16275244
9Macrocytic anemia (HP:0001972)4.03085837
10Colon cancer (HP:0003003)3.91262722
11IgM deficiency (HP:0002850)3.87221503
12Pallor (HP:0000980)3.86599505
13Thrombocytosis (HP:0001894)3.71877474
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.52542485
15Vacuolated lymphocytes (HP:0001922)3.50650189
16Selective tooth agenesis (HP:0001592)3.37582434
17Abnormality of the heme biosynthetic pathway (HP:0010472)3.35716022
18Microvesicular hepatic steatosis (HP:0001414)3.35128463
19Abnormal gallbladder physiology (HP:0012438)3.15502362
20Cholecystitis (HP:0001082)3.15502362
21Progressive muscle weakness (HP:0003323)3.13650334
22Abnormal mitochondria in muscle tissue (HP:0008316)3.03761148
23Loss of speech (HP:0002371)3.01589079
24Birth length less than 3rd percentile (HP:0003561)2.98797737
25Increased IgM level (HP:0003496)2.91033712
26Microretrognathia (HP:0000308)2.90599142
27Abnormality of glycolysis (HP:0004366)2.88021667
28Rough bone trabeculation (HP:0100670)2.87804387
29Increased serum pyruvate (HP:0003542)2.87490985
30Chronic otitis media (HP:0000389)2.86567946
31Shoulder girdle muscle weakness (HP:0003547)2.83225697
32Prolonged neonatal jaundice (HP:0006579)2.82981708
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.79843260
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.79843260
35Mutism (HP:0002300)2.78622073
36Mediastinal lymphadenopathy (HP:0100721)2.77469355
37Ependymoma (HP:0002888)2.76007452
38Hand muscle atrophy (HP:0009130)2.74023444
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.73449174
40Hepatosplenomegaly (HP:0001433)2.72651066
41Petechiae (HP:0000967)2.71402314
42Acute necrotizing encephalopathy (HP:0006965)2.71186791
43Carpal bone hypoplasia (HP:0001498)2.70448777
44Breast hypoplasia (HP:0003187)2.64339448
45Multiple enchondromatosis (HP:0005701)2.62274695
46Abnormality of macrophages (HP:0004311)2.57327588
47Hyperacusis (HP:0010780)2.56868067
48Abnormal respiratory motile cilium physiology (HP:0012261)2.56798985
49Upper motor neuron abnormality (HP:0002127)2.55582370
50Mitochondrial inheritance (HP:0001427)2.55558000
51Upper limb muscle weakness (HP:0003484)2.52342846
52Abnormal respiratory motile cilium morphology (HP:0005938)2.51605723
53Abnormal respiratory epithelium morphology (HP:0012253)2.51605723
54Nuclear cataract (HP:0100018)2.51186368
55Recurrent bronchitis (HP:0002837)2.50102842
56Abnormality of the musculature of the pelvis (HP:0001469)2.44440574
57Abnormality of the hip-girdle musculature (HP:0001445)2.44440574
58Recurrent bacterial skin infections (HP:0005406)2.42307051
59Acute encephalopathy (HP:0006846)2.40891565
60Upper limb amyotrophy (HP:0009129)2.40419427
61Distal upper limb amyotrophy (HP:0007149)2.40419427
62Ragged-red muscle fibers (HP:0003200)2.38023657
63Cerebral hypomyelination (HP:0006808)2.37462143
64Orchitis (HP:0100796)2.37271867
65Pancytopenia (HP:0001876)2.34834248
66Secondary amenorrhea (HP:0000869)2.34714310
67Pelvic girdle muscle weakness (HP:0003749)2.33952415
68Hypertensive crisis (HP:0100735)2.31513277
69Exercise intolerance (HP:0003546)2.31048377
70Increased CSF lactate (HP:0002490)2.30430501
71Abnormality of reticulocytes (HP:0004312)2.30079608
72Diminished motivation (HP:0000745)2.30015473
73Agnosia (HP:0010524)2.29059892
74Myositis (HP:0100614)2.28742712
75Disinhibition (HP:0000734)2.28693685
76Neoplasm of the pancreas (HP:0002894)2.28611600
77Premature graying of hair (HP:0002216)2.28597347
78Degeneration of anterior horn cells (HP:0002398)2.27928590
79Abnormality of the anterior horn cell (HP:0006802)2.27928590
80Muscle fiber atrophy (HP:0100295)2.27725541
81Axonal loss (HP:0003447)2.26841684
82Recurrent abscess formation (HP:0002722)2.26597379
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.25141473
84Abnormality of T cell physiology (HP:0011840)2.24178858
8511 pairs of ribs (HP:0000878)2.21418300
86Trismus (HP:0000211)2.20245530
87Abnormal number of incisors (HP:0011064)2.20025901
88Limb-girdle muscle atrophy (HP:0003797)2.19972719
89Retrobulbar optic neuritis (HP:0100654)2.19614336
90Optic neuritis (HP:0100653)2.19614336
91Neuronal loss in central nervous system (HP:0002529)2.18260323
92Elevated erythrocyte sedimentation rate (HP:0003565)2.16719055
93Abnormal ciliary motility (HP:0012262)2.15081029
94Absent thumb (HP:0009777)2.15039812
95Parakeratosis (HP:0001036)2.14671779
96Apathy (HP:0000741)2.14328483
97Rhinitis (HP:0012384)2.10705160
98Basal cell carcinoma (HP:0002671)2.08333054
99Acute lymphatic leukemia (HP:0006721)2.08028602
100Lymphoma (HP:0002665)2.07752134
101Dysostosis multiplex (HP:0000943)2.07385922
102Prolonged bleeding time (HP:0003010)2.07139515
103Premature ovarian failure (HP:0008209)2.07098714
104Entropion (HP:0000621)2.06933700
105Lactic acidosis (HP:0003128)2.05416342
106Respiratory failure (HP:0002878)2.03686212
107Megaloblastic anemia (HP:0001889)2.02570059
108Stomatitis (HP:0010280)1.99838669
109IgG deficiency (HP:0004315)1.96264143
110Patellar aplasia (HP:0006443)1.95836254
111Type I transferrin isoform profile (HP:0003642)1.95533529
112Interstitial pulmonary disease (HP:0006530)1.93818784
113Increased cerebral lipofuscin (HP:0011813)1.93208602
114Myelodysplasia (HP:0002863)1.91809832
115Rhabdomyolysis (HP:0003201)1.91368150
116Progressive neurologic deterioration (HP:0002344)1.90694379
117Hepatocellular necrosis (HP:0001404)1.89684457
118Progressive macrocephaly (HP:0004481)1.89612129
119Fasciculations (HP:0002380)1.89512622
120Personality changes (HP:0000751)1.89183336
121Systemic lupus erythematosus (HP:0002725)1.88552785
122Abnormality of the distal phalanges of the toes (HP:0010182)1.88385144
123Amaurosis fugax (HP:0100576)1.87817092
124Aplasia/Hypoplasia of the patella (HP:0006498)1.87271070
125Recurrent sinusitis (HP:0011108)1.86689205
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86503188
127Reduced antithrombin III activity (HP:0001976)1.86292416
128Abnormality of T cells (HP:0002843)1.85569976
129Abnormal trabecular bone morphology (HP:0100671)1.85392311
130Sparse eyelashes (HP:0000653)1.85344635
131Cellular immunodeficiency (HP:0005374)1.85307744
132Broad distal phalanx of finger (HP:0009836)1.85040814
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84839040
134Increased intramyocellular lipid droplets (HP:0012240)1.84454809
135Increased serum ferritin (HP:0003281)1.84431592
136Vertebral compression fractures (HP:0002953)1.83536397
137Hypokinesia (HP:0002375)1.83405268
138Hepatic necrosis (HP:0002605)1.82775685
139Medulloblastoma (HP:0002885)1.82110736
140Abnormality of the nasal mucosa (HP:0000433)1.82054707
141Poor head control (HP:0002421)1.81904142
142Atrophy/Degeneration involving motor neurons (HP:0007373)1.79980098
143Type 2 muscle fiber atrophy (HP:0003554)1.79590402
144Increased serum lactate (HP:0002151)1.78428434
145Bone marrow hypocellularity (HP:0005528)1.74865557
146Panhypogammaglobulinemia (HP:0003139)1.74830721
147Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73602379
148Broad face (HP:0000283)1.72898998
149Slender long bone (HP:0003100)1.72067040
150Abnormal neuron morphology (HP:0012757)1.69675575
151Abnormality of the motor neurons (HP:0002450)1.69675575
152Squamous cell carcinoma (HP:0002860)1.69215093
153Poikiloderma (HP:0001029)1.69015014
154Impaired platelet aggregation (HP:0003540)1.68401353
155Abnormal platelet function (HP:0011869)1.68401353
156Increased muscle lipid content (HP:0009058)1.66508480
157Pulmonary fibrosis (HP:0002206)1.65967126
158Emotional lability (HP:0000712)1.64885182
159Nasal polyposis (HP:0100582)1.64431753
160Epistaxis (HP:0000421)1.64242177
161Prominent nose (HP:0000448)1.63466001
162Abnormality of cells of the lymphoid lineage (HP:0012140)1.61703660
163Death in infancy (HP:0001522)1.61306357
164Spastic diplegia (HP:0001264)1.60660492
165Exertional dyspnea (HP:0002875)1.60087766
166Angiofibromas (HP:0010615)1.59343763
167Adenoma sebaceum (HP:0009720)1.59343763
168Pustule (HP:0200039)1.59299554
169Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59085594
170Abnormal protein N-linked glycosylation (HP:0012347)1.59085594
171Abnormal protein glycosylation (HP:0012346)1.59085594
172Abnormal glycosylation (HP:0012345)1.59085594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.55390396
2BUB13.70006482
3WEE13.62928581
4IRAK33.08340759
5TESK13.04544583
6EEF2K2.59451151
7VRK22.54863129
8STK162.53365880
9MAP4K12.43908066
10RPS6KA42.29575764
11BRD42.24323164
12ARAF2.20245772
13RPS6KB22.10144447
14CDC72.05823135
15NEK22.01769554
16FLT31.96060705
17PKN21.94842957
18TESK21.93914937
19PIM21.93167855
20KDR1.93073905
21TGFBR11.89239212
22EIF2AK11.87054330
23DYRK31.85449854
24ACVR1B1.82526938
25MAP2K71.79455054
26KIT1.77829053
27MAP3K101.67617178
28GRK71.66787338
29LIMK11.62744276
30BCKDK1.61942293
31PASK1.60382324
32TLK11.56884405
33SRPK11.55611583
34TRIB31.54378434
35MAP3K111.48752761
36JAK31.46933436
37LRRK21.46143506
38PRPF4B1.43777783
39SCYL21.40161464
40BTK1.39466982
41MAPKAPK31.38912982
42PAK61.37960421
43BRSK21.37366466
44PAK41.31521115
45PLK11.26973455
46IKBKE1.26355806
47SIK31.24535961
48ABL21.24061352
49VRK11.22561241
50MOS1.20669209
51CDK71.18395297
52ERN11.14871848
53MAP3K141.14036250
54CDK41.12557110
55TSSK61.12415766
56ATR1.12003520
57TTK1.11655496
58AURKB1.09770050
59BRSK11.09491414
60SMG11.09464321
61TRIM281.08485573
62TYK21.08191713
63MAP3K81.05262076
64CSF1R1.03532362
65CDK191.02464558
66PIM11.02142525
67BCR1.00933445
68SIK21.00489392
69CSNK1G30.98381115
70NEK10.95729341
71EPHA20.94618125
72CCNB10.94398335
73AURKA0.91986891
74ZAP700.91467912
75TAOK20.90056965
76MAP2K30.89778038
77IRAK20.89513194
78GRK60.88365279
79FGR0.87169262
80CHEK20.85714605
81MAP3K120.82227269
82MKNK10.80326192
83MATK0.78281407
84KSR20.77007949
85TBK10.74042097
86CSNK1A1L0.73821342
87BLK0.73705336
88STK100.72149503
89MAPK150.72005915
90EIF2AK30.71793147
91SYK0.71541533
92BRAF0.71211230
93TEC0.71176373
94NME10.70003086
95TAOK10.69424611
96DAPK30.67998953
97MKNK20.67591469
98DYRK1B0.65033011
99MAP3K10.64372936
100DDR20.64339740
101KSR10.64141206
102ILK0.63698166
103CSNK1G20.62850833
104CHEK10.61906646
105PLK40.61622274
106CSNK1G10.60832792
107MAPK110.59283214
108RAF10.58871344
109DAPK10.57394725
110EPHB20.57019600
111PAK10.56885429
112PBK0.51345582
113CDK140.50665010
114PDK20.50009741
115RPS6KA50.49765001
116CSNK2A20.49667415
117TIE10.47279250
118CHUK0.46506649
119PRKCI0.45517924
120CDK11A0.45345011
121LYN0.45162795
122CDK20.44294835
123RIPK10.43802417
124CSNK2A10.42593408
125TGFBR20.42545679
126CSK0.41647402
127LCK0.41052553
128CLK10.40954547
129IRAK40.39108834
130CDK180.38843409
131MAP2K20.36806937
132MAP3K30.36099839
133CDK150.36039279
134AKT20.34123540
135ICK0.33516315
136MST40.32954872
137IKBKB0.32423171
138ALK0.32098829
139CDK60.31238592
140MAP3K40.28418001
141FGFR40.27865325
142BMX0.26851614
143RPS6KA10.25708312
144MAPK40.25142175
145DYRK20.23185052
146MAP3K50.22503176
147FES0.21926216
148MUSK0.21761260

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.24564098
2Ribosome_Homo sapiens_hsa030105.05758764
3Mismatch repair_Homo sapiens_hsa034304.04152458
4Base excision repair_Homo sapiens_hsa034103.32268976
5Spliceosome_Homo sapiens_hsa030403.23865902
6Proteasome_Homo sapiens_hsa030503.10887111
7RNA polymerase_Homo sapiens_hsa030202.86132836
8Homologous recombination_Homo sapiens_hsa034402.74154627
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.67776919
10Pyrimidine metabolism_Homo sapiens_hsa002402.62480498
11Nucleotide excision repair_Homo sapiens_hsa034202.44139439
12RNA transport_Homo sapiens_hsa030132.32783911
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31802073
14One carbon pool by folate_Homo sapiens_hsa006702.18278248
15Fatty acid elongation_Homo sapiens_hsa000621.88946497
16Sulfur relay system_Homo sapiens_hsa041221.87038394
17Cell cycle_Homo sapiens_hsa041101.85572047
18Lysosome_Homo sapiens_hsa041421.83571235
19Folate biosynthesis_Homo sapiens_hsa007901.79234797
20Oxidative phosphorylation_Homo sapiens_hsa001901.78336160
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72134363
22Caffeine metabolism_Homo sapiens_hsa002321.56961207
23Rheumatoid arthritis_Homo sapiens_hsa053231.51329979
24Salmonella infection_Homo sapiens_hsa051321.49064702
25Vibrio cholerae infection_Homo sapiens_hsa051101.48104338
26p53 signaling pathway_Homo sapiens_hsa041151.46678995
27Primary immunodeficiency_Homo sapiens_hsa053401.45896270
28RNA degradation_Homo sapiens_hsa030181.44627003
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.35774605
30Antigen processing and presentation_Homo sapiens_hsa046121.34381492
31TNF signaling pathway_Homo sapiens_hsa046681.32086954
32Pentose phosphate pathway_Homo sapiens_hsa000301.31056579
33Allograft rejection_Homo sapiens_hsa053301.30274986
34Selenocompound metabolism_Homo sapiens_hsa004501.27589691
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.23952047
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23058468
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23020982
38Fanconi anemia pathway_Homo sapiens_hsa034601.22703512
39Collecting duct acid secretion_Homo sapiens_hsa049661.19724729
40Non-homologous end-joining_Homo sapiens_hsa034501.19362599
41Osteoclast differentiation_Homo sapiens_hsa043801.17756060
42Pertussis_Homo sapiens_hsa051331.17172410
43Biosynthesis of amino acids_Homo sapiens_hsa012301.15792914
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15282505
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.14796377
46Purine metabolism_Homo sapiens_hsa002301.13761055
47Malaria_Homo sapiens_hsa051441.10192288
48Steroid biosynthesis_Homo sapiens_hsa001001.09690766
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09298388
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08888780
51Tuberculosis_Homo sapiens_hsa051521.06966014
52Phagosome_Homo sapiens_hsa041451.06723621
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02794197
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02631866
55Systemic lupus erythematosus_Homo sapiens_hsa053221.00907252
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95366755
57Herpes simplex infection_Homo sapiens_hsa051680.92520326
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91726308
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90569644
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90501902
61Epstein-Barr virus infection_Homo sapiens_hsa051690.90389590
62Thyroid cancer_Homo sapiens_hsa052160.89528207
63N-Glycan biosynthesis_Homo sapiens_hsa005100.87733620
64Basal transcription factors_Homo sapiens_hsa030220.87637090
65Hepatitis C_Homo sapiens_hsa051600.86186963
66mRNA surveillance pathway_Homo sapiens_hsa030150.86113286
67Alzheimers disease_Homo sapiens_hsa050100.84414704
68Autoimmune thyroid disease_Homo sapiens_hsa053200.83044670
69Graft-versus-host disease_Homo sapiens_hsa053320.82256048
70Viral myocarditis_Homo sapiens_hsa054160.79134376
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78124206
72Carbon metabolism_Homo sapiens_hsa012000.77281148
73African trypanosomiasis_Homo sapiens_hsa051430.75613829
74Galactose metabolism_Homo sapiens_hsa000520.74699925
75Asthma_Homo sapiens_hsa053100.74026152
76Acute myeloid leukemia_Homo sapiens_hsa052210.70007353
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64974346
78Viral carcinogenesis_Homo sapiens_hsa052030.64604475
79Phenylalanine metabolism_Homo sapiens_hsa003600.64330687
80Toxoplasmosis_Homo sapiens_hsa051450.63860795
81Shigellosis_Homo sapiens_hsa051310.61120411
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61117575
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.60443716
84HTLV-I infection_Homo sapiens_hsa051660.60328896
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59285858
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58375886
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57644174
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56290203
89Peroxisome_Homo sapiens_hsa041460.56176124
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53769971
91Sphingolipid metabolism_Homo sapiens_hsa006000.53366170
92Protein export_Homo sapiens_hsa030600.53283479
93Apoptosis_Homo sapiens_hsa042100.52758549
94Prion diseases_Homo sapiens_hsa050200.52087008
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51136680
96B cell receptor signaling pathway_Homo sapiens_hsa046620.50841858
97Sulfur metabolism_Homo sapiens_hsa009200.49490297
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48931696
99Glutathione metabolism_Homo sapiens_hsa004800.48635670
100Small cell lung cancer_Homo sapiens_hsa052220.47886187
101Measles_Homo sapiens_hsa051620.47693622
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46787535
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46154450
104Legionellosis_Homo sapiens_hsa051340.45623137
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44765857
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43689364
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.42977205
108Fructose and mannose metabolism_Homo sapiens_hsa000510.42908816
109Other glycan degradation_Homo sapiens_hsa005110.42630181
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42319583
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41361014
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39384596
113Parkinsons disease_Homo sapiens_hsa050120.39023615
114Bladder cancer_Homo sapiens_hsa052190.38691560
115Hepatitis B_Homo sapiens_hsa051610.37840360
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36826478
117Huntingtons disease_Homo sapiens_hsa050160.35218259
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34572169
119Oocyte meiosis_Homo sapiens_hsa041140.34518875
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34289182
121Hematopoietic cell lineage_Homo sapiens_hsa046400.33426852
122Chronic myeloid leukemia_Homo sapiens_hsa052200.33130712
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32834266
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30028078
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.29307645
126Metabolic pathways_Homo sapiens_hsa011000.28809364
127Leishmaniasis_Homo sapiens_hsa051400.25719560
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24392543
129Arginine and proline metabolism_Homo sapiens_hsa003300.23845176
130Alcoholism_Homo sapiens_hsa050340.23548414
131Notch signaling pathway_Homo sapiens_hsa043300.21462637
132beta-Alanine metabolism_Homo sapiens_hsa004100.19660817
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19274804
134Vitamin digestion and absorption_Homo sapiens_hsa049770.18250082
135Non-small cell lung cancer_Homo sapiens_hsa052230.16741924
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15351252
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.15235923
138Influenza A_Homo sapiens_hsa051640.14904109
139Colorectal cancer_Homo sapiens_hsa052100.14191845
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14151537
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.13563002
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12190727
143HIF-1 signaling pathway_Homo sapiens_hsa040660.12002607

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