ADRA1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)6.75681693
2drug catabolic process (GO:0042737)6.07210255
3axon ensheathment in central nervous system (GO:0032291)5.62070157
4central nervous system myelination (GO:0022010)5.62070157
5omega-hydroxylase P450 pathway (GO:0097267)5.02808624
6tryptophan catabolic process (GO:0006569)4.92841003
7indole-containing compound catabolic process (GO:0042436)4.92841003
8indolalkylamine catabolic process (GO:0046218)4.92841003
9epoxygenase P450 pathway (GO:0019373)4.74891838
10behavioral response to nicotine (GO:0035095)4.57734577
11cellular ketone body metabolic process (GO:0046950)4.56055550
12gamma-aminobutyric acid transport (GO:0015812)4.44757257
13tryptophan metabolic process (GO:0006568)4.37919386
14oxidative demethylation (GO:0070989)4.37162372
15neuron cell-cell adhesion (GO:0007158)4.36551495
16presynaptic membrane assembly (GO:0097105)4.36491340
17kynurenine metabolic process (GO:0070189)4.31773943
18pyrimidine nucleobase catabolic process (GO:0006208)4.27036070
19aromatic amino acid family catabolic process (GO:0009074)4.17399469
20glyoxylate metabolic process (GO:0046487)4.13601678
21presynaptic membrane organization (GO:0097090)4.10652318
22ketone body metabolic process (GO:1902224)4.06565355
23S-adenosylmethionine metabolic process (GO:0046500)3.96742939
24indolalkylamine metabolic process (GO:0006586)3.96307967
25response to pheromone (GO:0019236)3.89345251
26L-amino acid import (GO:0043092)3.87370751
27fucose catabolic process (GO:0019317)3.86919933
28L-fucose metabolic process (GO:0042354)3.86919933
29L-fucose catabolic process (GO:0042355)3.86919933
30long-chain fatty acid biosynthetic process (GO:0042759)3.76074592
31fatty acid elongation (GO:0030497)3.73511535
32nucleobase catabolic process (GO:0046113)3.72533092
33complement activation, alternative pathway (GO:0006957)3.64204029
34drug metabolic process (GO:0017144)3.61367081
35amino acid import (GO:0043090)3.57452242
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57234436
37vocalization behavior (GO:0071625)3.52611048
38neuronal action potential propagation (GO:0019227)3.51151701
39negative regulation of neurotransmitter transport (GO:0051589)3.40337603
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.37753512
41water-soluble vitamin biosynthetic process (GO:0042364)3.33249906
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.32527742
43L-phenylalanine catabolic process (GO:0006559)3.32527742
44amine catabolic process (GO:0009310)3.29925556
45cellular biogenic amine catabolic process (GO:0042402)3.29925556
46indole-containing compound metabolic process (GO:0042430)3.26745918
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.25971446
48amino acid salvage (GO:0043102)3.25333463
49L-methionine salvage (GO:0071267)3.25333463
50L-methionine biosynthetic process (GO:0071265)3.25333463
51bile acid biosynthetic process (GO:0006699)3.23922172
52serine family amino acid catabolic process (GO:0009071)3.23586864
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.20624653
54neurotransmitter-gated ion channel clustering (GO:0072578)3.20092648
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16777642
56ionotropic glutamate receptor signaling pathway (GO:0035235)3.13058173
57arginine metabolic process (GO:0006525)3.11331901
58negative regulation of neurotransmitter secretion (GO:0046929)3.10815401
59neuronal action potential (GO:0019228)3.10810423
60cellular glucuronidation (GO:0052695)3.09425303
61regulation of protein activation cascade (GO:2000257)3.07483916
62aromatic amino acid family metabolic process (GO:0009072)3.06645083
63succinate metabolic process (GO:0006105)3.06526832
64uronic acid metabolic process (GO:0006063)3.05046842
65glucuronate metabolic process (GO:0019585)3.05046842
66regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.05041425
67* negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03626368
68neurotransmitter uptake (GO:0001504)3.02945781
69benzene-containing compound metabolic process (GO:0042537)3.02919526
70myelination (GO:0042552)3.01380892
71regulation of triglyceride catabolic process (GO:0010896)2.99122061
72negative regulation of protein localization to cell surface (GO:2000009)2.98406036
73transmission of nerve impulse (GO:0019226)2.98068726
74protein-cofactor linkage (GO:0018065)2.96459508
75ensheathment of neurons (GO:0007272)2.95683581
76axon ensheathment (GO:0008366)2.95683581
77glutamate receptor signaling pathway (GO:0007215)2.92962616
78coenzyme catabolic process (GO:0009109)2.92864986
79arginine catabolic process (GO:0006527)2.92188514
80dicarboxylic acid catabolic process (GO:0043649)2.91599353
81regulation of complement activation (GO:0030449)2.90910303
82startle response (GO:0001964)2.90797746
83neuron recognition (GO:0008038)2.89633786
84positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88467149
85respiratory electron transport chain (GO:0022904)2.86315008
86postsynaptic membrane organization (GO:0001941)2.85526811
87alanine transport (GO:0032328)2.84547147
88import into cell (GO:0098657)2.83903395
89regulation of glutamate receptor signaling pathway (GO:1900449)2.82672010
90detection of light stimulus involved in sensory perception (GO:0050962)2.81304016
91detection of light stimulus involved in visual perception (GO:0050908)2.81304016
92ethanol oxidation (GO:0006069)2.76778025
93cerebral cortex radially oriented cell migration (GO:0021799)2.76758461
94alpha-amino acid catabolic process (GO:1901606)2.76545649
95electron transport chain (GO:0022900)2.76224529
96neuron-neuron synaptic transmission (GO:0007270)2.76090275
97response to epinephrine (GO:0071871)2.75552706
98positive regulation of synapse assembly (GO:0051965)2.75522415
99protein polyglutamylation (GO:0018095)2.74612834
100glycerophospholipid catabolic process (GO:0046475)2.74356462
101phenylpropanoid metabolic process (GO:0009698)2.73007373
102positive regulation of fatty acid transport (GO:2000193)2.72481327
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71755411
104protein localization to synapse (GO:0035418)2.70681462
105bile acid metabolic process (GO:0008206)2.68020792
106cysteine metabolic process (GO:0006534)2.67446581
107L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66056627
108epithelial cilium movement (GO:0003351)2.65247509
109glycine transport (GO:0015816)2.64837290
110mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.63115331
111dopamine transport (GO:0015872)2.63056193
112methionine biosynthetic process (GO:0009086)2.62411568
113bile acid and bile salt transport (GO:0015721)2.59512377
114oligodendrocyte differentiation (GO:0048709)2.58696562
115* positive regulation of action potential (GO:0045760)2.57457751
116platelet dense granule organization (GO:0060155)2.56306526
117flavonoid metabolic process (GO:0009812)2.56302146
118alkaloid metabolic process (GO:0009820)2.56302006
119cellular response to epinephrine stimulus (GO:0071872)2.55545117
120regulation of glucokinase activity (GO:0033131)2.55459627
121regulation of hexokinase activity (GO:1903299)2.55459627
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55191918
123DNA deamination (GO:0045006)2.54494584
124cAMP catabolic process (GO:0006198)2.54241223
125positive regulation of amino acid transport (GO:0051957)2.53694613
126adult walking behavior (GO:0007628)2.52679726
127amino-acid betaine metabolic process (GO:0006577)2.52526046
128positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.52432997
129primary amino compound metabolic process (GO:1901160)2.50969087
130opsonization (GO:0008228)2.50040131
131synaptic transmission, glutamatergic (GO:0035249)2.49987959
132neuron remodeling (GO:0016322)2.49925076
133axoneme assembly (GO:0035082)2.49751515
134acidic amino acid transport (GO:0015800)2.49254165
135erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.49129809
136L-phenylalanine metabolic process (GO:0006558)2.49129809
137sulfation (GO:0051923)2.49116224
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49037859
139limb bud formation (GO:0060174)2.48999291
140C4-dicarboxylate transport (GO:0015740)2.48524346
141ATP synthesis coupled proton transport (GO:0015986)2.46674255
142energy coupled proton transport, down electrochemical gradient (GO:0015985)2.46674255
143imidazole-containing compound metabolic process (GO:0052803)2.46094731
144cellular amino acid catabolic process (GO:0009063)2.45454545
145synaptic vesicle exocytosis (GO:0016079)2.44713100
146tyrosine metabolic process (GO:0006570)2.40968343
147regulation of synaptic transmission, glutamatergic (GO:0051966)2.39164551
148xenobiotic catabolic process (GO:0042178)2.38856247
149negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.38268985
150regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.36681595
151organic cation transport (GO:0015695)2.35447096
152piRNA metabolic process (GO:0034587)2.34969479
153kidney morphogenesis (GO:0060993)2.34649750
154nonmotile primary cilium assembly (GO:0035058)2.33932096
155membrane assembly (GO:0071709)2.33812909
156* negative regulation of synaptic transmission (GO:0050805)2.33466085
157positive regulation of organic acid transport (GO:0032892)2.33339385
158neurotransmitter metabolic process (GO:0042133)2.32959003
159neurotransmitter secretion (GO:0007269)2.32664656
160short-term memory (GO:0007614)2.31863670
161aldehyde catabolic process (GO:0046185)2.31732763
162cilium morphogenesis (GO:0060271)2.31648967
163regulation of fibrinolysis (GO:0051917)2.31354943
164peptidyl-glutamic acid modification (GO:0018200)2.31126197
165regulation of sequestering of triglyceride (GO:0010889)2.30089755
166long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.29294116
167energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.28877460
168ATP hydrolysis coupled proton transport (GO:0015991)2.28877460
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.27544848
170regulation of short-term neuronal synaptic plasticity (GO:0048172)2.26943983
171regulation of collateral sprouting (GO:0048670)2.26687701
172neurotransmitter transport (GO:0006836)2.26624847
173retina layer formation (GO:0010842)2.26021069
174regulation of synapse assembly (GO:0051963)2.24458647
175cerebellar granule cell differentiation (GO:0021707)2.24260177
176synapse assembly (GO:0007416)2.24200833
177detection of calcium ion (GO:0005513)2.23841689
178positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.23732628
179response to cocaine (GO:0042220)2.23582835
180negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.22070923
181response to auditory stimulus (GO:0010996)2.21821513
182fatty-acyl-CoA metabolic process (GO:0035337)2.21723141
183* regulation of synaptic transmission, GABAergic (GO:0032228)2.21078379
184eye photoreceptor cell differentiation (GO:0001754)2.21076840
185photoreceptor cell differentiation (GO:0046530)2.21076840
186long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.21051318
187regulation of cardiac muscle cell contraction (GO:0086004)2.20544657
188response to methylmercury (GO:0051597)2.18478707
189aggressive behavior (GO:0002118)2.18362243
190regulation of excitatory postsynaptic membrane potential (GO:0060079)2.18219457
191response to histamine (GO:0034776)2.17665470
192regulation of respiratory system process (GO:0044065)2.17097919
193fatty-acyl-CoA biosynthetic process (GO:0046949)2.16247336
194axonal fasciculation (GO:0007413)2.15527432
195potassium ion import (GO:0010107)2.15315934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.09918574
2GBX2_23144817_ChIP-Seq_PC3_Human3.95106525
3ZNF274_21170338_ChIP-Seq_K562_Hela3.59703021
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65599209
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62713139
6TAF15_26573619_Chip-Seq_HEK293_Human2.58737740
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54759832
8* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31462960
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28282872
10* EED_16625203_ChIP-ChIP_MESCs_Mouse2.27411395
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23855236
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22814541
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.22584863
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22012528
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16469304
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16469304
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11478605
18AR_21572438_ChIP-Seq_LNCaP_Human2.04819198
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04284940
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99104798
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91861312
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87197936
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85655030
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85354386
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84985853
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84811725
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.83921164
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.82838729
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80218986
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78695100
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78181008
32P300_19829295_ChIP-Seq_ESCs_Human1.77560242
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75146252
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72701673
35* EZH2_27294783_Chip-Seq_ESCs_Mouse1.70666505
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.69055382
37VDR_22108803_ChIP-Seq_LS180_Human1.64977759
38SMAD4_21799915_ChIP-Seq_A2780_Human1.63807953
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.62936011
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60409734
41EWS_26573619_Chip-Seq_HEK293_Human1.59992637
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59862546
43ER_23166858_ChIP-Seq_MCF-7_Human1.59836486
44* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56240456
45FUS_26573619_Chip-Seq_HEK293_Human1.55706687
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.54788715
47* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54625077
48IRF1_19129219_ChIP-ChIP_H3396_Human1.54050804
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52067999
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48827777
51DROSHA_22980978_ChIP-Seq_HELA_Human1.47799619
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47558903
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44382612
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43957363
55* REST_21632747_ChIP-Seq_MESCs_Mouse1.43013443
56* CBP_20019798_ChIP-Seq_JUKART_Human1.42814285
57* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42814285
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42367040
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41358398
60* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40683542
61* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40442599
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40351572
63IGF1R_20145208_ChIP-Seq_DFB_Human1.39461104
64TP53_22573176_ChIP-Seq_HFKS_Human1.35754335
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35151869
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34252534
67NANOG_19829295_ChIP-Seq_ESCs_Human1.32038601
68SOX2_19829295_ChIP-Seq_ESCs_Human1.32038601
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.30344122
70TCF4_22108803_ChIP-Seq_LS180_Human1.29370374
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.28302490
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27222747
73AR_25329375_ChIP-Seq_VCAP_Human1.26264392
74STAT3_23295773_ChIP-Seq_U87_Human1.24286099
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23637948
76RNF2_27304074_Chip-Seq_NSC_Mouse1.23484989
77* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22769467
78* FOXA1_25329375_ChIP-Seq_VCAP_Human1.22769467
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21524416
80* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21503759
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21427934
82* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18841398
83TP53_18474530_ChIP-ChIP_U2OS_Human1.17967972
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17353926
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.16114682
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.15618267
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.15162317
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.14730647
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14407303
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14291735
91TCF4_23295773_ChIP-Seq_U87_Human1.13684836
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13348787
93P53_22387025_ChIP-Seq_ESCs_Mouse1.12823240
94AHR_22903824_ChIP-Seq_MCF-7_Human1.12407657
95NCOR_22424771_ChIP-Seq_293T_Human1.12354624
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12048208
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.11460705
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11391242
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.11366319
100* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11206748
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.11112970
102* RUNX2_22187159_ChIP-Seq_PCA_Human1.10891175
103MYC_18940864_ChIP-ChIP_HL60_Human1.09142567
104AR_20517297_ChIP-Seq_VCAP_Human1.08885763
105* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08848742
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05931442
107* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05335232
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04738214
109KDM2B_26808549_Chip-Seq_REH_Human1.04674529
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04415095
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04415095
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04410182
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.04354135
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04328792
115BCAT_22108803_ChIP-Seq_LS180_Human1.03729785
116* REST_18959480_ChIP-ChIP_MESCs_Mouse1.03690346
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03610449
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03417805
119STAT3_18555785_Chip-Seq_ESCs_Mouse1.02584311
120P300_18555785_Chip-Seq_ESCs_Mouse1.02017110
121* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01673431
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01575677
123TP53_16413492_ChIP-PET_HCT116_Human1.01498617
124AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01380536
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00994319
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00263645
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00263645
128EZH2_27294783_Chip-Seq_NPCs_Mouse0.99840500
129* FLI1_21867929_ChIP-Seq_TH2_Mouse0.99797177
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99527930
131TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99347911
132MYC_19829295_ChIP-Seq_ESCs_Human0.99328251
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.99203463
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98887279
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.98723831
136HTT_18923047_ChIP-ChIP_STHdh_Human0.98685851
137TAL1_26923725_Chip-Seq_HPCs_Mouse0.98602063
138SOX2_18555785_Chip-Seq_ESCs_Mouse0.98333430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.83738889
2MP0008875_abnormal_xenobiotic_pharmacok3.75583541
3MP0002139_abnormal_hepatobiliary_system3.52008588
4MP0009046_muscle_twitch3.04396992
5MP0005085_abnormal_gallbladder_physiolo2.94279435
6MP0002064_seizures2.68606493
7MP0001486_abnormal_startle_reflex2.66582313
8MP0009745_abnormal_behavioral_response2.61925311
9MP0004859_abnormal_synaptic_plasticity2.52106717
10MP0002272_abnormal_nervous_system2.51027065
11MP0003635_abnormal_synaptic_transmissio2.50248701
12MP0005365_abnormal_bile_salt2.41879246
13MP0003136_yellow_coat_color2.36995536
14MP0003252_abnormal_bile_duct2.35495890
15MP0002138_abnormal_hepatobiliary_system2.34446756
16MP0002837_dystrophic_cardiac_calcinosis2.27720369
17MP0003690_abnormal_glial_cell2.24841643
18MP0003646_muscle_fatigue2.22705754
19MP0000920_abnormal_myelination2.20834563
20MP0005423_abnormal_somatic_nervous2.15763286
21MP0004270_analgesia2.14182468
22MP0002572_abnormal_emotion/affect_behav2.12776942
23MP0001529_abnormal_vocalization2.07677342
24MP0001501_abnormal_sleep_pattern2.06898833
25MP0001968_abnormal_touch/_nociception2.05383753
26MP0001440_abnormal_grooming_behavior2.04371392
27MP0003011_delayed_dark_adaptation2.00111762
28MP0008877_abnormal_DNA_methylation1.98472479
29MP0005646_abnormal_pituitary_gland1.96358664
30MP0002063_abnormal_learning/memory/cond1.95221389
31MP0005171_absent_coat_pigmentation1.94069367
32MP0002736_abnormal_nociception_after1.89744654
33MP0002735_abnormal_chemical_nociception1.83462218
34MP0006072_abnormal_retinal_apoptosis1.80280345
35MP0004742_abnormal_vestibular_system1.79482334
36MP0004142_abnormal_muscle_tone1.76955255
37MP0002734_abnormal_mechanical_nocicepti1.76060202
38MP0002067_abnormal_sensory_capabilities1.74857572
39MP0010329_abnormal_lipoprotein_level1.72057004
40MP0008872_abnormal_physiological_respon1.71841036
41MP0001188_hyperpigmentation1.69065211
42MP0004133_heterotaxia1.67908664
43MP0005645_abnormal_hypothalamus_physiol1.64343429
44MP0005360_urolithiasis1.62233587
45MP0005409_darkened_coat_color1.61368563
46MP0005253_abnormal_eye_physiology1.61236777
47MP0006292_abnormal_olfactory_placode1.60246979
48MP0006276_abnormal_autonomic_nervous1.57897952
49MP0000778_abnormal_nervous_system1.57209776
50MP0003329_amyloid_beta_deposits1.53748802
51MP0000566_synostosis1.53259741
52MP0003787_abnormal_imprinting1.52387816
53MP0004043_abnormal_pH_regulation1.48947438
54MP0005670_abnormal_white_adipose1.48836078
55MP0005386_behavior/neurological_phenoty1.41293177
56MP0004924_abnormal_behavior1.41293177
57MP0005551_abnormal_eye_electrophysiolog1.37797687
58MP0001905_abnormal_dopamine_level1.35745487
59MP0001986_abnormal_taste_sensitivity1.34522423
60MP0003950_abnormal_plasma_membrane1.33094450
61MP0001970_abnormal_pain_threshold1.33086387
62MP0009780_abnormal_chondrocyte_physiolo1.32688022
63MP0003283_abnormal_digestive_organ1.29880169
64MP0003634_abnormal_glial_cell1.29054218
65MP0004130_abnormal_muscle_cell1.28381648
66MP0000751_myopathy1.27738054
67MP0002653_abnormal_ependyma_morphology1.27648660
68MP0001984_abnormal_olfaction1.27125035
69MP0004885_abnormal_endolymph1.26974110
70MP0002733_abnormal_thermal_nociception1.26475805
71MP0002557_abnormal_social/conspecific_i1.23418439
72MP0008569_lethality_at_weaning1.19290673
73MP0005084_abnormal_gallbladder_morpholo1.19181993
74MP0001963_abnormal_hearing_physiology1.18793386
75MP0002234_abnormal_pharynx_morphology1.18679617
76* MP0004215_abnormal_myocardial_fiber1.18372093
77MP0002229_neurodegeneration1.17554649
78MP0001485_abnormal_pinna_reflex1.15683291
79MP0005535_abnormal_body_temperature1.15258354
80MP0003137_abnormal_impulse_conducting1.15182708
81MP0005377_hearing/vestibular/ear_phenot1.15120297
82MP0003878_abnormal_ear_physiology1.15120297
83MP0003195_calcinosis1.14629647
84MP0000427_abnormal_hair_cycle1.13957213
85MP0002876_abnormal_thyroid_physiology1.13525290
86MP0002066_abnormal_motor_capabilities/c1.13272360
87MP0002882_abnormal_neuron_morphology1.08670407
88MP0002184_abnormal_innervation1.08076042
89MP0000569_abnormal_digit_pigmentation1.07942001
90MP0004381_abnormal_hair_follicle1.07629398
91MP0001764_abnormal_homeostasis1.05814992
92MP0003633_abnormal_nervous_system1.04684851
93MP0005410_abnormal_fertilization1.02588530
94MP0000631_abnormal_neuroendocrine_gland1.02559340
95MP0004145_abnormal_muscle_electrophysio1.01594985
96MP0000026_abnormal_inner_ear1.00324443
97MP0000372_irregular_coat_pigmentation0.98857924
98MP0003631_nervous_system_phenotype0.98050646
99MP0002928_abnormal_bile_duct0.96924587
100MP0004858_abnormal_nervous_system0.96786933
101MP0005187_abnormal_penis_morphology0.94987562
102MP0000955_abnormal_spinal_cord0.94217118
103MP0002909_abnormal_adrenal_gland0.93472015
104* MP0004484_altered_response_of0.93342783
105MP0004036_abnormal_muscle_relaxation0.93136048
106MP0000604_amyloidosis0.91283511
107MP0002822_catalepsy0.91025831
108MP0002752_abnormal_somatic_nervous0.90914658
109MP0005666_abnormal_adipose_tissue0.90498581
110MP0002282_abnormal_trachea_morphology0.89841319
111* MP0004085_abnormal_heartbeat0.88987395
112MP0002102_abnormal_ear_morphology0.88909295
113MP0003632_abnormal_nervous_system0.87939666
114MP0003938_abnormal_ear_development0.87613859
115MP0001502_abnormal_circadian_rhythm0.86512751
116MP0008260_abnormal_autophagy0.86186925
117MP0009764_decreased_sensitivity_to0.86146647
118MP0004147_increased_porphyrin_level0.86084967
119MP0005167_abnormal_blood-brain_barrier0.84278057
120MP0005448_abnormal_energy_balance0.83449721
121* MP0000230_abnormal_systemic_arterial0.80856121
122MP0001666_abnormal_nutrient_absorption0.78755109
123MP0005332_abnormal_amino_acid0.78675657
124* MP0002972_abnormal_cardiac_muscle0.78601839
125MP0010368_abnormal_lymphatic_system0.76306863
126MP0002971_abnormal_brown_adipose0.75727741
127MP0001177_atelectasis0.75355328
128MP0008874_decreased_physiological_sensi0.74187134
129* MP0005620_abnormal_muscle_contractility0.74066958
130MP0001661_extended_life_span0.74005500
131MP0005379_endocrine/exocrine_gland_phen0.73484347
132MP0004185_abnormal_adipocyte_glucose0.71769374
133MP0002751_abnormal_autonomic_nervous0.71689109
134MP0010386_abnormal_urinary_bladder0.71462850
135MP0005636_abnormal_mineral_homeostasis0.70631597
136MP0005195_abnormal_posterior_eye0.67641885
137MP0002152_abnormal_brain_morphology0.66808880
138MP0002090_abnormal_vision0.66512631
139MP0003879_abnormal_hair_cell0.64837290
140MP0002118_abnormal_lipid_homeostasis0.63580482
141MP0005330_cardiomyopathy0.63350357
142MP0002069_abnormal_eating/drinking_beha0.62486657
143MP0002638_abnormal_pupillary_reflex0.61400752

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.73055631
2Hyperventilation (HP:0002883)4.54220095
3Pancreatic cysts (HP:0001737)4.37346064
4Pancreatic fibrosis (HP:0100732)3.89111255
5True hermaphroditism (HP:0010459)3.77744138
6Molar tooth sign on MRI (HP:0002419)3.76414743
7Abnormality of midbrain morphology (HP:0002418)3.76414743
8Atonic seizures (HP:0010819)3.74106402
9Acute necrotizing encephalopathy (HP:0006965)3.67756970
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.56402038
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.56402038
12Congenital stationary night blindness (HP:0007642)3.55013915
13Febrile seizures (HP:0002373)3.54551183
14Epileptic encephalopathy (HP:0200134)3.52788035
15Neurofibrillary tangles (HP:0002185)3.52661118
16Nephronophthisis (HP:0000090)3.40932242
17Complement deficiency (HP:0004431)3.36721293
18Progressive macrocephaly (HP:0004481)3.36185087
19Acute encephalopathy (HP:0006846)3.29580861
20Abnormal mitochondria in muscle tissue (HP:0008316)3.27757384
21Focal seizures (HP:0007359)3.21644882
22Prolonged partial thromboplastin time (HP:0003645)3.21512219
23Abnormality of the renal cortex (HP:0011035)3.16193267
24Conjugated hyperbilirubinemia (HP:0002908)3.13711233
25Chronic hepatic failure (HP:0100626)2.98366417
26Type II lissencephaly (HP:0007260)2.93894754
27Bile duct proliferation (HP:0001408)2.88664361
28Abnormal biliary tract physiology (HP:0012439)2.88664361
29Abnormality of the renal medulla (HP:0100957)2.88656031
30Attenuation of retinal blood vessels (HP:0007843)2.83166209
31Abolished electroretinogram (ERG) (HP:0000550)2.82763690
32Generalized tonic-clonic seizures (HP:0002069)2.82171446
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81732297
34Abnormality of alanine metabolism (HP:0010916)2.81732297
35Hyperalaninemia (HP:0003348)2.81732297
36Dialeptic seizures (HP:0011146)2.78879027
37Progressive inability to walk (HP:0002505)2.78514262
38Mitochondrial inheritance (HP:0001427)2.76382377
39Tubular atrophy (HP:0000092)2.76043806
40Cystic liver disease (HP:0006706)2.74165339
41Aplasia involving bones of the extremities (HP:0009825)2.70757917
42Aplasia involving bones of the upper limbs (HP:0009823)2.70757917
43Aplasia of the phalanges of the hand (HP:0009802)2.70757917
44Pheochromocytoma (HP:0002666)2.67578741
45Abnormality of glycolysis (HP:0004366)2.67229724
46Increased serum pyruvate (HP:0003542)2.67229724
47Absence seizures (HP:0002121)2.66637922
48Hyperglycinuria (HP:0003108)2.63582907
49Cerebral edema (HP:0002181)2.62996314
50Abnormality of the corticospinal tract (HP:0002492)2.60644746
51Optic disc pallor (HP:0000543)2.55716698
52Broad-based gait (HP:0002136)2.55392032
53Large for gestational age (HP:0001520)2.54196631
54Neuroendocrine neoplasm (HP:0100634)2.51797666
55Hemiparesis (HP:0001269)2.51333442
56Renal cortical cysts (HP:0000803)2.51032542
57Polydipsia (HP:0001959)2.50903187
58Abnormal drinking behavior (HP:0030082)2.50903187
59Hyperglycinemia (HP:0002154)2.49642224
60Diplopia (HP:0000651)2.49500957
61Abnormality of binocular vision (HP:0011514)2.49500957
62Leukodystrophy (HP:0002415)2.48706616
63Cerebral inclusion bodies (HP:0100314)2.44170952
64Hypothermia (HP:0002045)2.43361056
65Ketosis (HP:0001946)2.41642962
66Parakeratosis (HP:0001036)2.39781040
67Pendular nystagmus (HP:0012043)2.39614808
68Clumsiness (HP:0002312)2.38921649
69Abnormality of glycine metabolism (HP:0010895)2.38715335
70Abnormality of serine family amino acid metabolism (HP:0010894)2.38715335
71Sclerocornea (HP:0000647)2.37787299
72Hypoplastic left heart (HP:0004383)2.36298899
73Myokymia (HP:0002411)2.34901666
74Methylmalonic acidemia (HP:0002912)2.33666559
75Abnormal rod and cone electroretinograms (HP:0008323)2.31597267
76Increased CSF lactate (HP:0002490)2.27841792
77Hepatocellular necrosis (HP:0001404)2.25962112
78Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23660254
79Generalized aminoaciduria (HP:0002909)2.22295658
80Sensory axonal neuropathy (HP:0003390)2.20053192
81Dysmetria (HP:0001310)2.18415671
82Congenital hepatic fibrosis (HP:0002612)2.18330410
83Absent speech (HP:0001344)2.16991984
84Hypobetalipoproteinemia (HP:0003563)2.15207126
85Lissencephaly (HP:0001339)2.14931664
86Polyphagia (HP:0002591)2.13232547
87Synostosis involving the elbow (HP:0003938)2.12904414
88Humeroradial synostosis (HP:0003041)2.12904414
89Abnormality of monocarboxylic acid metabolism (HP:0010996)2.12265619
90Congenital primary aphakia (HP:0007707)2.12220159
91Delayed CNS myelination (HP:0002188)2.11523157
92Muscle hypertrophy of the lower extremities (HP:0008968)2.10423953
93Gaze-evoked nystagmus (HP:0000640)2.10140936
94Anencephaly (HP:0002323)2.09741486
95Dysdiadochokinesis (HP:0002075)2.09562736
96Decreased central vision (HP:0007663)2.09331595
97Thickened helices (HP:0000391)2.08966613
98Exercise-induced myalgia (HP:0003738)2.08801191
99Confusion (HP:0001289)2.08343004
100Increased corneal curvature (HP:0100692)2.07925021
101Keratoconus (HP:0000563)2.07925021
102Hepatic necrosis (HP:0002605)2.07474376
103Cerebral hemorrhage (HP:0001342)2.06935087
104Nephrogenic diabetes insipidus (HP:0009806)2.05825813
105Blue irides (HP:0000635)2.05067918
106Male pseudohermaphroditism (HP:0000037)2.03615347
107Furrowed tongue (HP:0000221)2.03259183
108Renal Fanconi syndrome (HP:0001994)2.03177164
109Glycosuria (HP:0003076)2.02433132
110Abnormality of urine glucose concentration (HP:0011016)2.02433132
111Abnormality of complement system (HP:0005339)2.01929686
112Split foot (HP:0001839)2.01436749
113Metabolic alkalosis (HP:0200114)2.01416668
114Polyuria (HP:0000103)2.00335819
115Drooling (HP:0002307)1.98268447
116Excessive salivation (HP:0003781)1.98268447
117Generalized myoclonic seizures (HP:0002123)1.98260983
118Respiratory failure (HP:0002878)1.98007160
119Inability to walk (HP:0002540)1.97548572
120Absent/shortened dynein arms (HP:0200106)1.97012855
121Dynein arm defect of respiratory motile cilia (HP:0012255)1.97012855
122Supranuclear gaze palsy (HP:0000605)1.95415251
123Abnormal respiratory epithelium morphology (HP:0012253)1.95415052
124Abnormal respiratory motile cilium morphology (HP:0005938)1.95415052
125Abnormal eating behavior (HP:0100738)1.94207930
126Spontaneous abortion (HP:0005268)1.94190583
127X-linked dominant inheritance (HP:0001423)1.94081337
128Abnormality of serum amino acid levels (HP:0003112)1.93658085
1293-Methylglutaconic aciduria (HP:0003535)1.93373053
130Epidermoid cyst (HP:0200040)1.93057914
131Hemiplegia (HP:0002301)1.90978122
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.90255941
133Postaxial foot polydactyly (HP:0001830)1.88837002
134Pachygyria (HP:0001302)1.88271675
135Hypoplasia of the iris (HP:0007676)1.88237193
136Abnormal hair whorl (HP:0010721)1.88190366
137Ketoacidosis (HP:0001993)1.88133594
138Hypoplastic heart (HP:0001961)1.87415307
139Cerebellar dysplasia (HP:0007033)1.86349780
140Bony spicule pigmentary retinopathy (HP:0007737)1.85778855
141Congenital, generalized hypertrichosis (HP:0004540)1.85624546
142Scanning speech (HP:0002168)1.85070571
143Widely spaced teeth (HP:0000687)1.84971599
144Chorioretinal atrophy (HP:0000533)1.84950904
145Optic nerve hypoplasia (HP:0000609)1.84111020
146Abnormal urine output (HP:0012590)1.83978175
147Fair hair (HP:0002286)1.82000153
148Severe muscular hypotonia (HP:0006829)1.81736668
149Occipital encephalocele (HP:0002085)1.80906647
150Intrahepatic cholestasis (HP:0001406)1.80842334
151Tachypnea (HP:0002789)1.79498010
152Medial flaring of the eyebrow (HP:0010747)1.78574457
153Lactic acidosis (HP:0003128)1.77393870
154Congenital sensorineural hearing impairment (HP:0008527)1.76747478
155Hypophosphatemic rickets (HP:0004912)1.75960818
156Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.75141373
157Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74630699
158Spastic gait (HP:0002064)1.74298662
159Status epilepticus (HP:0002133)1.72725549
160Onion bulb formation (HP:0003383)1.72535692
161Slow saccadic eye movements (HP:0000514)1.71396848
162Vaginal atresia (HP:0000148)1.71087914
163Increased circulating renin level (HP:0000848)1.69737262
164Progressive cerebellar ataxia (HP:0002073)1.69559990
165Peripheral hypomyelination (HP:0007182)1.69266840
166Calf muscle hypertrophy (HP:0008981)1.69137160
167Retinal dysplasia (HP:0007973)1.68470977
168Genital tract atresia (HP:0001827)1.68447952
169Methylmalonic aciduria (HP:0012120)1.67560410
170Abnormality of renal resorption (HP:0011038)1.66934764
171Gait imbalance (HP:0002141)1.66616240
172Truncal ataxia (HP:0002078)1.66612170
173Lipid accumulation in hepatocytes (HP:0006561)1.65410651
174Hyperlipoproteinemia (HP:0010980)1.65205856
175Increased hepatocellular lipid droplets (HP:0006565)1.63485126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.93614104
2CASK4.42342927
3STK393.26694319
4MAP4K22.97382223
5OXSR12.96997618
6EPHA42.40647749
7TAOK32.32839565
8PKN12.24896379
9ZAK2.22808105
10NTRK32.16871557
11TNIK2.10106396
12MUSK2.07192023
13NUAK12.05955363
14PNCK2.04533044
15MAP2K72.03921418
16ACVR1B1.98750040
17TLK11.89241840
18GRK71.79181911
19ERBB41.78184498
20TXK1.64214394
21BCR1.63159659
22CAMK1G1.59271513
23PBK1.58697063
24MAP3K41.54976206
25INSRR1.53164934
26PHKG21.51840400
27PHKG11.51840400
28PRPF4B1.47858623
29NTRK21.44337481
30PRKCE1.38573795
31NEK61.34322439
32WNK41.34181444
33SGK2231.34124512
34SGK4941.34124512
35MST41.31708053
36FGR1.30847930
37CAMK2B1.27816522
38MARK11.26999233
39CAMKK21.26399686
40AKT31.24424254
41CAMK2A1.24364155
42CAMK2D1.21513282
43FGFR21.20252183
44FES1.15298009
45MAPK151.09898289
46PIK3CA1.08404018
47SIK21.05800671
48PDK21.03033838
49ADRBK21.02379744
50EPHB11.02005204
51WNK11.01156163
52BMPR1B1.00299528
53MAPK130.99590515
54NTRK10.98504921
55EPHA30.97950106
56TRIM280.96622384
57PAK60.94473072
58CDK190.93739086
59PLK20.93694369
60CSNK1G10.92241397
61CAMK2G0.92193273
62BMPR20.90534637
63SGK20.90184134
64TGFBR10.89236445
65STK160.87059812
66CDK50.86209437
67IRAK20.86073447
68CAMK1D0.86028209
69PAK30.84413473
70ROCK20.83463472
71GRK10.79961373
72IRAK30.79414154
73OBSCN0.75225208
74MAP2K40.75030452
75UHMK10.74618550
76PDK30.74104532
77PDK40.74104532
78MAPKAPK50.74075009
79SGK10.74018720
80NLK0.73983493
81PRKCG0.73809682
82WNK30.73740405
83PRKAA20.73302979
84NME10.72136872
85PRKCQ0.71428784
86TIE10.71386059
87YES10.71278627
88MAPK70.71266893
89MAPK120.71134040
90CDK30.69227330
91MAP2K60.69226108
92PINK10.69058142
93MYLK0.68701693
94BCKDK0.68629075
95MKNK20.68460447
96CAMK10.67867804
97PRKACA0.64741807
98PRKG10.64096867
99DAPK20.63866747
100ERBB30.63654747
101KIT0.62873172
102RIPK40.62381142
103STK38L0.61505625
104RPS6KA50.59330231
105MARK20.58657119
106TNK20.58157879
107PDPK10.57550394
108PIK3CG0.56811388
109STK110.53888275
110CSNK1G20.53348980
111FER0.52919428
112DYRK1A0.51868757
113SGK30.51450570
114PRKCZ0.50075058
115GRK50.50063654
116FYN0.47235574
117PRKAA10.46752915
118MKNK10.46547164
119CSNK1A10.45532235
120EIF2AK30.45427528
121MAP3K120.45282578
122IGF1R0.45206328
123ADRBK10.45152921
124IRAK10.45048759
125TEC0.43779101
126VRK10.42093071
127CSNK1A1L0.41487112
128MAPKAPK30.41103441
129PLK40.40773293
130IKBKB0.40443895
131PRKACB0.40134526
132PRKACG0.39798121
133PTK2B0.39768116
134FLT30.39635089
135PRKCA0.39292899
136DYRK20.39235280
137CSNK1G30.37862457
138CHUK0.36090224
139ITK0.34827232
140CSNK1D0.33977428
141PRKCI0.33465343

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.26645586
2Caffeine metabolism_Homo sapiens_hsa002323.23490323
3Fatty acid elongation_Homo sapiens_hsa000622.97159571
4Oxidative phosphorylation_Homo sapiens_hsa001902.91867659
5Nicotine addiction_Homo sapiens_hsa050332.71104058
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49354311
7Butanoate metabolism_Homo sapiens_hsa006502.38965031
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.35382054
9Propanoate metabolism_Homo sapiens_hsa006402.31434220
10Chemical carcinogenesis_Homo sapiens_hsa052042.25100538
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16058216
12GABAergic synapse_Homo sapiens_hsa047272.12046221
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01393213
14Collecting duct acid secretion_Homo sapiens_hsa049661.95930890
15Complement and coagulation cascades_Homo sapiens_hsa046101.92449338
16Parkinsons disease_Homo sapiens_hsa050121.92284961
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92149199
18Alzheimers disease_Homo sapiens_hsa050101.91537192
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82354655
20Fatty acid metabolism_Homo sapiens_hsa012121.78866065
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.73386134
22Morphine addiction_Homo sapiens_hsa050321.69852665
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.66086986
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61029452
25Cardiac muscle contraction_Homo sapiens_hsa042601.60977207
26Glutamatergic synapse_Homo sapiens_hsa047241.59062966
27Steroid biosynthesis_Homo sapiens_hsa001001.56762054
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54731152
29Fatty acid biosynthesis_Homo sapiens_hsa000611.50858459
30ABC transporters_Homo sapiens_hsa020101.47769629
31Arachidonic acid metabolism_Homo sapiens_hsa005901.41422252
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41148347
33Selenocompound metabolism_Homo sapiens_hsa004501.41106360
34Taste transduction_Homo sapiens_hsa047421.40750142
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37251618
36* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37246074
37Synaptic vesicle cycle_Homo sapiens_hsa047211.35633146
38Serotonergic synapse_Homo sapiens_hsa047261.35393383
39Fatty acid degradation_Homo sapiens_hsa000711.29807056
40Huntingtons disease_Homo sapiens_hsa050161.27489940
41beta-Alanine metabolism_Homo sapiens_hsa004101.25430520
42Ether lipid metabolism_Homo sapiens_hsa005651.20407859
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20165887
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.16414344
45Sulfur metabolism_Homo sapiens_hsa009201.16224898
46Circadian entrainment_Homo sapiens_hsa047131.15498865
47PPAR signaling pathway_Homo sapiens_hsa033201.13515156
48Nitrogen metabolism_Homo sapiens_hsa009101.13296697
49* Salivary secretion_Homo sapiens_hsa049701.12260284
50Vitamin B6 metabolism_Homo sapiens_hsa007501.11833502
51Pyruvate metabolism_Homo sapiens_hsa006201.10603163
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09326082
53Phenylalanine metabolism_Homo sapiens_hsa003601.07540785
54Histidine metabolism_Homo sapiens_hsa003401.05986065
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05534973
56Phototransduction_Homo sapiens_hsa047441.04263940
57Long-term depression_Homo sapiens_hsa047301.03307970
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03186857
59One carbon pool by folate_Homo sapiens_hsa006701.02163543
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00758594
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.99754072
62Renin secretion_Homo sapiens_hsa049240.98281743
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95640251
64Fat digestion and absorption_Homo sapiens_hsa049750.95608158
65Peroxisome_Homo sapiens_hsa041460.95115859
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94160587
67* Calcium signaling pathway_Homo sapiens_hsa040200.94147813
68Olfactory transduction_Homo sapiens_hsa047400.94118326
69Rheumatoid arthritis_Homo sapiens_hsa053230.90694902
70Gastric acid secretion_Homo sapiens_hsa049710.89907586
71Axon guidance_Homo sapiens_hsa043600.89907233
72Vibrio cholerae infection_Homo sapiens_hsa051100.88059240
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87487544
74Protein export_Homo sapiens_hsa030600.87130500
75Sphingolipid metabolism_Homo sapiens_hsa006000.84498975
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79880739
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78478715
78Insulin secretion_Homo sapiens_hsa049110.75835406
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.75129156
80Dopaminergic synapse_Homo sapiens_hsa047280.71530533
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70975021
82Dilated cardiomyopathy_Homo sapiens_hsa054140.70541438
83Starch and sucrose metabolism_Homo sapiens_hsa005000.70387904
84cAMP signaling pathway_Homo sapiens_hsa040240.68998366
85Cholinergic synapse_Homo sapiens_hsa047250.67935094
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67235288
87Arginine biosynthesis_Homo sapiens_hsa002200.65350450
88Amphetamine addiction_Homo sapiens_hsa050310.65252965
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63493664
90Cocaine addiction_Homo sapiens_hsa050300.62178084
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61466182
92* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58662415
93Arginine and proline metabolism_Homo sapiens_hsa003300.58607797
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58496141
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.57186211
96Phagosome_Homo sapiens_hsa041450.56177391
97Long-term potentiation_Homo sapiens_hsa047200.55964370
98Tryptophan metabolism_Homo sapiens_hsa003800.55115213
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.54722443
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54136725
101Regulation of autophagy_Homo sapiens_hsa041400.53873704
102Retinol metabolism_Homo sapiens_hsa008300.53718762
103Vitamin digestion and absorption_Homo sapiens_hsa049770.53422481
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52972498
105Ovarian steroidogenesis_Homo sapiens_hsa049130.52642838
106Glycerolipid metabolism_Homo sapiens_hsa005610.51594780
107Type I diabetes mellitus_Homo sapiens_hsa049400.51254258
108Oxytocin signaling pathway_Homo sapiens_hsa049210.50720566
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49344744
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49269674
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.48646270
112* Vascular smooth muscle contraction_Homo sapiens_hsa042700.48614290
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48247322
114Basal transcription factors_Homo sapiens_hsa030220.47368222
115Asthma_Homo sapiens_hsa053100.46964153
116Sulfur relay system_Homo sapiens_hsa041220.46874164
117Staphylococcus aureus infection_Homo sapiens_hsa051500.46634361
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.44985301
119Bile secretion_Homo sapiens_hsa049760.43731066
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43392552
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42708650
122Circadian rhythm_Homo sapiens_hsa047100.42311955
123Tyrosine metabolism_Homo sapiens_hsa003500.42125489
124Metabolic pathways_Homo sapiens_hsa011000.41786600
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41093261
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41001129
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40997556
128RNA polymerase_Homo sapiens_hsa030200.40451621
129African trypanosomiasis_Homo sapiens_hsa051430.40330291
130Linoleic acid metabolism_Homo sapiens_hsa005910.39719746
131Mineral absorption_Homo sapiens_hsa049780.39709653
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.38995859
133Pancreatic secretion_Homo sapiens_hsa049720.37964846
134RNA degradation_Homo sapiens_hsa030180.31170637

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