ADRA1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.96005880
2synaptic vesicle maturation (GO:0016188)5.86467101
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.74226009
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.53232067
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.26822978
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.17566068
7vocalization behavior (GO:0071625)5.14614530
8glutamate secretion (GO:0014047)5.07379240
9regulation of glutamate receptor signaling pathway (GO:1900449)4.91256716
10kidney mesenchyme development (GO:0072074)4.85156304
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.80418261
12metanephric mesenchyme development (GO:0072075)4.71140896
13regulation of neuronal synaptic plasticity (GO:0048168)4.70242465
14synaptic vesicle exocytosis (GO:0016079)4.67969695
15muscle organ morphogenesis (GO:0048644)4.66110229
16exploration behavior (GO:0035640)4.52420904
17dorsal/ventral neural tube patterning (GO:0021904)4.50097396
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.46340386
19dendritic spine morphogenesis (GO:0060997)4.42772917
20response to gravity (GO:0009629)4.29886179
21positive regulation of fibroblast migration (GO:0010763)4.28321515
22protein localization to synapse (GO:0035418)4.28061152
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.24180919
24protein heterotrimerization (GO:0070208)4.12663057
25regulation of synaptic vesicle exocytosis (GO:2000300)4.10650024
26response to phenylpropanoid (GO:0080184)4.08016049
27positive regulation of synapse maturation (GO:0090129)4.01164399
28neuronal action potential propagation (GO:0019227)3.97294148
29dendritic spine organization (GO:0097061)3.96352234
30regulation of synapse structural plasticity (GO:0051823)3.95330065
31skin morphogenesis (GO:0043589)3.93843543
32glutamate receptor signaling pathway (GO:0007215)3.92648213
33peripheral nervous system neuron development (GO:0048935)3.91804739
34sodium ion export (GO:0071436)3.91392220
35synaptic transmission, glutamatergic (GO:0035249)3.85708761
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.78306986
37long-term memory (GO:0007616)3.75136838
38G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.74373843
39regulation of synaptic vesicle transport (GO:1902803)3.74078285
40regulation of synaptic plasticity (GO:0048167)3.73079816
41cellular potassium ion homeostasis (GO:0030007)3.72971168
42proline transport (GO:0015824)3.72870286
43neurotransmitter-gated ion channel clustering (GO:0072578)3.72596929
44cell communication by electrical coupling (GO:0010644)3.69711632
45planar cell polarity pathway involved in neural tube closure (GO:0090179)3.67911417
46regulation of dendritic spine morphogenesis (GO:0061001)3.65128771
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64822671
48middle ear morphogenesis (GO:0042474)3.62982134
49proximal/distal pattern formation (GO:0009954)3.62909213
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.61564096
51regulation of glomerular filtration (GO:0003093)3.59697437
52layer formation in cerebral cortex (GO:0021819)3.57382255
53prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.55875130
54positive regulation of membrane potential (GO:0045838)3.50252717
55activation of protein kinase A activity (GO:0034199)3.47457249
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47337264
57neurotransmitter secretion (GO:0007269)3.42683920
58heparan sulfate proteoglycan metabolic process (GO:0030201)3.39381280
59endocardial cushion development (GO:0003197)3.38958035
60innervation (GO:0060384)3.37122576
61regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.37054391
62regulation of postsynaptic membrane potential (GO:0060078)3.34598562
63collagen fibril organization (GO:0030199)3.30752869
64neuron projection extension involved in neuron projection guidance (GO:1902284)3.30647971
65axon extension involved in axon guidance (GO:0048846)3.30647971
66outer ear morphogenesis (GO:0042473)3.30232034
67adherens junction assembly (GO:0034333)3.27356406
68neuromuscular process controlling balance (GO:0050885)3.23379561
69cellular sodium ion homeostasis (GO:0006883)3.23322387
70Leydig cell differentiation (GO:0033327)3.21066660
71L-amino acid import (GO:0043092)3.20703779
72chemosensory behavior (GO:0007635)3.20668787
73neuron-neuron synaptic transmission (GO:0007270)3.20437932
74heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.19433681
75protein retention in ER lumen (GO:0006621)3.17352896
76extracellular matrix assembly (GO:0085029)3.17000860
77cytoskeletal anchoring at plasma membrane (GO:0007016)3.15388319
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.15200281
79regulation of ARF protein signal transduction (GO:0032012)3.13438067
80positive regulation of male gonad development (GO:2000020)3.13197806
81type B pancreatic cell proliferation (GO:0044342)3.11938476
82cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.10125515
83cell migration involved in sprouting angiogenesis (GO:0002042)3.09601446
84cerebellar Purkinje cell layer development (GO:0021680)3.09074113
85positive regulation of dendritic spine development (GO:0060999)3.08046943
86cell-substrate adherens junction assembly (GO:0007045)3.08033551
87focal adhesion assembly (GO:0048041)3.08033551
88embryonic skeletal joint morphogenesis (GO:0060272)3.06810667
89neuron recognition (GO:0008038)3.06347376
90regulation of vesicle fusion (GO:0031338)3.05924924
91maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.05053052
92regulation of dendritic spine development (GO:0060998)3.03070641
93long-term synaptic potentiation (GO:0060291)3.02388818
94dendrite morphogenesis (GO:0048813)3.01146578
95neuron cell-cell adhesion (GO:0007158)3.00243015
96axonal fasciculation (GO:0007413)2.98931627
97chondrocyte proliferation (GO:0035988)2.98531920
98signal complex assembly (GO:0007172)2.94455440
99positive regulation of dendritic spine morphogenesis (GO:0061003)2.93816844
100adrenal gland development (GO:0030325)2.93782947
101establishment of nucleus localization (GO:0040023)2.93246153
102synaptic vesicle endocytosis (GO:0048488)2.92197365
103negative regulation of nitric-oxide synthase activity (GO:0051001)2.91138623
104negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.89511535
105endothelial cell chemotaxis (GO:0035767)2.86952366
106cochlea morphogenesis (GO:0090103)2.86345301
107stress fiber assembly (GO:0043149)2.86090107
108membrane depolarization (GO:0051899)2.84467794
109facial nerve structural organization (GO:0021612)2.83553482
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.83497477
111cell-cell junction maintenance (GO:0045217)2.82068160
112regulation of synapse maturation (GO:0090128)2.81804390
113behavioral defense response (GO:0002209)2.80376751
114behavioral fear response (GO:0001662)2.80376751
115regulation of synaptic transmission (GO:0050804)2.80120751
116mammary gland development (GO:0030879)2.79845930
117cell-substrate junction assembly (GO:0007044)2.79585294
118anterior/posterior axis specification, embryo (GO:0008595)2.79025978
119regulation of neurotransmitter secretion (GO:0046928)2.78325845
120gamma-aminobutyric acid signaling pathway (GO:0007214)2.77864042
121membrane depolarization during action potential (GO:0086010)2.77475373
122forelimb morphogenesis (GO:0035136)2.77209879
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76217337
124regulation of mammary gland epithelial cell proliferation (GO:0033599)2.74569755
125regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.74501103
126plasma membrane repair (GO:0001778)2.74448372
127cell migration involved in heart development (GO:0060973)2.72110683
128cellular response to ketone (GO:1901655)2.71677084
129positive regulation of vesicle fusion (GO:0031340)2.70555405
130glycine transport (GO:0015816)2.70261250
131embryonic skeletal system morphogenesis (GO:0048704)2.70089938
132protein localization to endosome (GO:0036010)2.69554224
133long term synaptic depression (GO:0060292)2.68650793
134neuromuscular process controlling posture (GO:0050884)2.68475953
135embryonic forelimb morphogenesis (GO:0035115)2.67945423
136mammary gland epithelial cell proliferation (GO:0033598)2.67753492
137regulation of synaptic transmission, glutamatergic (GO:0051966)2.67742353
138negative regulation of axon extension involved in axon guidance (GO:0048843)2.66855235
139learning (GO:0007612)2.66111074
140urinary tract smooth muscle contraction (GO:0014848)2.65635804
141transmission of nerve impulse (GO:0019226)2.65370253
142neurotransmitter transport (GO:0006836)2.64615889
143retina vasculature morphogenesis in camera-type eye (GO:0061299)2.64207257
144gamma-aminobutyric acid transport (GO:0015812)2.63803766
145ephrin receptor signaling pathway (GO:0048013)2.63738550
146negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.61079439
147G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61014406
148convergent extension (GO:0060026)2.59972953
149type B pancreatic cell development (GO:0003323)2.59179978
150neuromuscular process (GO:0050905)2.58577830
151inner ear receptor cell development (GO:0060119)2.58549242
152alanine transport (GO:0032328)2.58256133
153fear response (GO:0042596)2.57676131
154glomerular basement membrane development (GO:0032836)2.56655609
155regulation of organ formation (GO:0003156)2.56313179
156cellular response to electrical stimulus (GO:0071257)2.56190749
157neuronal ion channel clustering (GO:0045161)2.55398864
158positive regulation of synaptic transmission (GO:0050806)2.54904967
159paraxial mesoderm development (GO:0048339)2.54443376
160negative regulation of smooth muscle cell migration (GO:0014912)2.52574881
161positive regulation of actin filament depolymerization (GO:0030836)2.52565275
162Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.49871362
163regulation of early endosome to late endosome transport (GO:2000641)2.48868710
164positive regulation of Rho protein signal transduction (GO:0035025)2.47678065
165axon extension (GO:0048675)2.46998992
166branching involved in prostate gland morphogenesis (GO:0060442)2.46044837
167endodermal cell differentiation (GO:0035987)2.44059101
168cranial nerve structural organization (GO:0021604)2.43207262
169lens morphogenesis in camera-type eye (GO:0002089)2.42629943
170response to magnesium ion (GO:0032026)2.42458910
171skeletal system morphogenesis (GO:0048705)2.41062973
172dermatan sulfate biosynthetic process (GO:0030208)2.39509120
173epithelial cell-cell adhesion (GO:0090136)2.39152628
174bone trabecula formation (GO:0060346)2.38932131
175regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38231135
176regulation of the force of heart contraction (GO:0002026)2.38217930
177regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.37340457
178dermatan sulfate metabolic process (GO:0030205)2.36411484
179regulation of establishment of planar polarity (GO:0090175)2.36221001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.00543088
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.36989895
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10694438
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02742248
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99981053
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.94179281
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.94179281
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76530108
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.76271934
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67567561
11DROSHA_22980978_ChIP-Seq_HELA_Human2.64198343
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63130146
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59862281
14GBX2_23144817_ChIP-Seq_PC3_Human2.51082115
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50863984
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.49656870
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43600190
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.38494294
19* EZH2_27304074_Chip-Seq_ESCs_Mouse2.32069068
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.30935814
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30421487
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.28324228
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.27771147
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.22384526
25REST_21632747_ChIP-Seq_MESCs_Mouse2.21342358
26WT1_19549856_ChIP-ChIP_CCG9911_Human2.20797701
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12824563
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09484263
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97298828
30* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.96543058
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.82945081
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.81731091
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.75613396
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.74638765
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73216891
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.64549456
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.64549456
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.64549456
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63162648
40CLOCK_20551151_ChIP-Seq_293T_Human1.59208309
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.57743034
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51221156
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50798271
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.48693308
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48421239
46KDM2B_26808549_Chip-Seq_K562_Human1.48313363
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47338394
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46616848
49SMC1_22415368_ChIP-Seq_MEFs_Mouse1.43709045
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42367877
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41557879
52* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40630333
53SMC3_22415368_ChIP-Seq_MEFs_Mouse1.40345213
54* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37617152
55RACK7_27058665_Chip-Seq_MCF-7_Human1.36712519
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34412489
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.32764862
58* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31591562
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30841576
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30182955
61ZNF274_21170338_ChIP-Seq_K562_Hela1.26896746
62AR_21572438_ChIP-Seq_LNCaP_Human1.26643334
63TP53_22127205_ChIP-Seq_IMR90_Human1.26620828
64ZNF263_19887448_ChIP-Seq_K562_Human1.25547496
65* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25167536
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24462605
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22742642
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21804887
69* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21187521
70SMAD4_21799915_ChIP-Seq_A2780_Human1.19238860
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18938164
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18581153
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.18501859
74BRD4_25478319_ChIP-Seq_HGPS_Human1.18276350
75LXR_22292898_ChIP-Seq_THP-1_Human1.17236555
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.16535396
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16303604
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15734642
79* TP53_20018659_ChIP-ChIP_R1E_Mouse1.15604180
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15058955
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14547011
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14004768
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13537963
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12223630
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12055708
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11889890
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09150187
88* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07234927
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07162092
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07089770
91* AR_19668381_ChIP-Seq_PC3_Human1.06842417
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06777996
93* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04752347
94CTCF_27219007_Chip-Seq_Bcells_Human1.04293568
95SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03206980
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02964833
97TP53_16413492_ChIP-PET_HCT116_Human1.02085129
98CREB1_26743006_Chip-Seq_LNCaP_Human1.01859757
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.01756292
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01553680
101SMAD3_21741376_ChIP-Seq_HESCs_Human1.01306200
102TP63_17297297_ChIP-ChIP_HaCaT_Human1.00935978
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00840168
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00382040
105RXR_22108803_ChIP-Seq_LS180_Human1.00208001
106* SA1_22415368_ChIP-Seq_MEFs_Mouse0.99391855
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99061218
108AR_25329375_ChIP-Seq_VCAP_Human0.98775524
109ISL1_27105846_Chip-Seq_CPCs_Mouse0.97469641
110CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97210545
111STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96286645
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95859274
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.95856817
114* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95436757
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95107518
116SMAD_19615063_ChIP-ChIP_OVARY_Human0.94252018
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94102025
118ATF3_27146783_Chip-Seq_COLON_Human0.93467050
119* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93265650
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92722198
121CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92564601
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.92295530
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.92158303
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.91156825
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91095072
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.89850715
127* TP53_18474530_ChIP-ChIP_U2OS_Human0.89280050
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89175668
129KDM2B_26808549_Chip-Seq_DND41_Human0.88754657
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88310335
131* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88014615
132AHR_22903824_ChIP-Seq_MCF-7_Human0.87739517
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87417871
134KLF4_19829295_ChIP-Seq_ESCs_Human0.86918997
135KDM2B_26808549_Chip-Seq_JURKAT_Human0.85494621
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84812979
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84812979
138* TP53_23651856_ChIP-Seq_MEFs_Mouse0.84626676
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84389911
140YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83322513
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81941291
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81147204
143SMC4_20622854_ChIP-Seq_HELA_Human0.80814946
144* SMAD3_21741376_ChIP-Seq_ESCs_Human0.80402835
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78185344
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.78170260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity8.35005002
2MP0003880_abnormal_central_pattern4.09333796
3* MP0003635_abnormal_synaptic_transmissio3.98647214
4MP0004270_analgesia3.15883537
5* MP0002063_abnormal_learning/memory/cond3.14906758
6* MP0009745_abnormal_behavioral_response2.88369861
7MP0009384_cardiac_valve_regurgitation2.79521022
8MP0002064_seizures2.78466455
9MP0008438_abnormal_cutaneous_collagen2.73369484
10MP0004858_abnormal_nervous_system2.60536006
11MP0009053_abnormal_anal_canal2.52478734
12MP0009780_abnormal_chondrocyte_physiolo2.50212344
13MP0003950_abnormal_plasma_membrane2.47004659
14MP0005623_abnormal_meninges_morphology2.37314682
15MP0002572_abnormal_emotion/affect_behav2.30606452
16MP0001968_abnormal_touch/_nociception2.21239427
17MP0003329_amyloid_beta_deposits2.15383647
18MP0002272_abnormal_nervous_system2.10703214
19MP0001501_abnormal_sleep_pattern2.04776635
20MP0009046_muscle_twitch1.93569351
21MP0000751_myopathy1.89926813
22MP0002736_abnormal_nociception_after1.79332564
23MP0002734_abnormal_mechanical_nocicepti1.78366028
24MP0005508_abnormal_skeleton_morphology1.77660242
25MP0002735_abnormal_chemical_nociception1.77318697
26MP0001440_abnormal_grooming_behavior1.76723947
27MP0008569_lethality_at_weaning1.76314852
28MP0002932_abnormal_joint_morphology1.75733711
29* MP0001486_abnormal_startle_reflex1.74055129
30MP0000767_abnormal_smooth_muscle1.73679099
31MP0003566_abnormal_cell_adhesion1.69230850
32MP0001542_abnormal_bone_strength1.67899838
33MP0003075_altered_response_to1.65728202
34MP0005257_abnormal_intraocular_pressure1.65072443
35MP0004811_abnormal_neuron_physiology1.64912368
36MP0005076_abnormal_cell_differentiation1.64209605
37MP0005423_abnormal_somatic_nervous1.60286652
38MP0005275_abnormal_skin_tensile1.55499165
39MP0003879_abnormal_hair_cell1.54442409
40MP0005394_taste/olfaction_phenotype1.54200829
41MP0005499_abnormal_olfactory_system1.54200829
42MP0000534_abnormal_ureter_morphology1.48585038
43MP0003942_abnormal_urinary_system1.46956198
44MP0000762_abnormal_tongue_morphology1.46852181
45MP0003385_abnormal_body_wall1.44714678
46MP0000013_abnormal_adipose_tissue1.43601697
47MP0002837_dystrophic_cardiac_calcinosis1.42504523
48MP0002896_abnormal_bone_mineralization1.40437955
49MP0002909_abnormal_adrenal_gland1.39601973
50MP0009250_abnormal_appendicular_skeleto1.38718714
51MP0005023_abnormal_wound_healing1.37060498
52MP0000778_abnormal_nervous_system1.36253626
53MP0003705_abnormal_hypodermis_morpholog1.35119953
54MP0010030_abnormal_orbit_morphology1.33258996
55MP0001970_abnormal_pain_threshold1.33232859
56MP0005503_abnormal_tendon_morphology1.32754334
57MP0000750_abnormal_muscle_regeneration1.31584681
58MP0003283_abnormal_digestive_organ1.31175892
59MP0002184_abnormal_innervation1.30107665
60MP0000428_abnormal_craniofacial_morphol1.30001304
61MP0000049_abnormal_middle_ear1.27915928
62MP0002733_abnormal_thermal_nociception1.25875831
63MP0004130_abnormal_muscle_cell1.25735787
64MP0003633_abnormal_nervous_system1.25609880
65MP0001177_atelectasis1.24599075
66MP0002653_abnormal_ependyma_morphology1.23096809
67MP0000955_abnormal_spinal_cord1.21897782
68MP0002067_abnormal_sensory_capabilities1.21168636
69MP0003279_aneurysm1.20062591
70MP0002102_abnormal_ear_morphology1.18958241
71MP0004510_myositis1.18203385
72MP0002295_abnormal_pulmonary_circulatio1.16702304
73MP0002882_abnormal_neuron_morphology1.15051024
74MP0010368_abnormal_lymphatic_system1.14799564
75* MP0002066_abnormal_motor_capabilities/c1.13161549
76MP0001958_emphysema1.12623702
77MP0003045_fibrosis1.12420768
78MP0002822_catalepsy1.12322523
79MP0002116_abnormal_craniofacial_bone1.11835554
80MP0002163_abnormal_gland_morphology1.11615746
81MP0002557_abnormal_social/conspecific_i1.10957233
82MP0004885_abnormal_endolymph1.10093598
83MP0000163_abnormal_cartilage_morphology1.06538808
84MP0005390_skeleton_phenotype1.05835882
85MP0002114_abnormal_axial_skeleton1.05234368
86MP0004233_abnormal_muscle_weight1.04694275
87MP0003631_nervous_system_phenotype1.03337653
88MP0003755_abnormal_palate_morphology0.99201770
89MP0003091_abnormal_cell_migration0.98749944
90MP0002060_abnormal_skin_morphology0.98316182
91MP0001348_abnormal_lacrimal_gland0.97847171
92MP0008961_abnormal_basal_metabolism0.97707564
93MP0003828_pulmonary_edema0.94186678
94MP0000604_amyloidosis0.93916212
95MP0002115_abnormal_skeleton_extremities0.92808614
96MP0002233_abnormal_nose_morphology0.92568076
97MP0004484_altered_response_of0.91547855
98MP0004145_abnormal_muscle_electrophysio0.91188540
99MP0002152_abnormal_brain_morphology0.90769932
100MP0000467_abnormal_esophagus_morphology0.90715752
101MP0000733_abnormal_muscle_development0.90175362
102MP0001849_ear_inflammation0.89681259
103MP0005409_darkened_coat_color0.87932486
104MP0002249_abnormal_larynx_morphology0.86289148
105MP0004215_abnormal_myocardial_fiber0.85249992
106MP0001502_abnormal_circadian_rhythm0.84752247
107MP0008874_decreased_physiological_sensi0.83329663
108MP0005386_behavior/neurological_phenoty0.83111311
109MP0004924_abnormal_behavior0.83111311
110MP0002090_abnormal_vision0.82038422
111MP0000003_abnormal_adipose_tissue0.80915016
112MP0002332_abnormal_exercise_endurance0.80768408
113MP0000749_muscle_degeneration0.79349332
114MP0005535_abnormal_body_temperature0.78743899
115MP0004085_abnormal_heartbeat0.78741539
116MP0000432_abnormal_head_morphology0.77899292
117MP0001299_abnormal_eye_distance/0.77895129
118MP0003634_abnormal_glial_cell0.77805617
119MP0004185_abnormal_adipocyte_glucose0.77774949
120MP0003787_abnormal_imprinting0.77630193
121MP0010386_abnormal_urinary_bladder0.77541817
122MP0003878_abnormal_ear_physiology0.76940239
123MP0005377_hearing/vestibular/ear_phenot0.76940239
124MP0005595_abnormal_vascular_smooth0.75435945
125MP0002069_abnormal_eating/drinking_beha0.74929690
126MP0002089_abnormal_postnatal_growth/wei0.74447830
127MP0003937_abnormal_limbs/digits/tail_de0.74213975
128MP0004272_abnormal_basement_membrane0.73941253
129MP0005670_abnormal_white_adipose0.73553782
130MP0003690_abnormal_glial_cell0.73553735
131MP0010234_abnormal_vibrissa_follicle0.73087179
132MP0002234_abnormal_pharynx_morphology0.73000527
133MP0000920_abnormal_myelination0.72780053
134MP0005375_adipose_tissue_phenotype0.72737706
135MP0006054_spinal_hemorrhage0.72508618
136MP0002108_abnormal_muscle_morphology0.72077600
137MP0003115_abnormal_respiratory_system0.71920434
138MP0003935_abnormal_craniofacial_develop0.71798572
139MP0003191_abnormal_cellular_cholesterol0.71669648
140MP0004087_abnormal_muscle_fiber0.71286459
141MP0005164_abnormal_response_to0.70714551
142MP0005369_muscle_phenotype0.69822573
143MP0000759_abnormal_skeletal_muscle0.68674482
144MP0000747_muscle_weakness0.68014175
145MP0005620_abnormal_muscle_contractility0.67705513
146MP0005666_abnormal_adipose_tissue0.67663538
147MP0001905_abnormal_dopamine_level0.67544692
148MP0003632_abnormal_nervous_system0.67113638
149MP0002109_abnormal_limb_morphology0.66659408
150MP0002111_abnormal_tail_morphology0.66505987
151MP0005330_cardiomyopathy0.66001854
152MP0005410_abnormal_fertilization0.65056398
153MP0000639_abnormal_adrenal_gland0.65013032
154MP0003137_abnormal_impulse_conducting0.64632613
155MP0002133_abnormal_respiratory_system0.64370264
156MP0006138_congestive_heart_failure0.63307845
157MP0003119_abnormal_digestive_system0.61475514
158MP0002113_abnormal_skeleton_development0.61409520

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.17381162
2Focal motor seizures (HP:0011153)5.85123479
3Focal seizures (HP:0007359)4.49431706
4Protrusio acetabuli (HP:0003179)4.35213764
5Visual hallucinations (HP:0002367)4.21431357
6Premature rupture of membranes (HP:0001788)3.89951933
7Atonic seizures (HP:0010819)3.88176309
8Aortic aneurysm (HP:0004942)3.73263017
9Shallow orbits (HP:0000586)3.58214010
10Action tremor (HP:0002345)3.51080556
11Abnormality of the lower motor neuron (HP:0002366)3.51007031
12Progressive cerebellar ataxia (HP:0002073)3.47744020
13Epileptic encephalopathy (HP:0200134)3.40411901
14Calcaneovalgus deformity (HP:0001848)3.38154550
15Cervical subluxation (HP:0003308)3.23536255
16Dislocated radial head (HP:0003083)3.22975737
17Febrile seizures (HP:0002373)3.22019926
18Bundle branch block (HP:0011710)3.08636639
19Impaired vibration sensation in the lower limbs (HP:0002166)3.06309774
20Generalized tonic-clonic seizures (HP:0002069)3.02459388
21Deformed tarsal bones (HP:0008119)3.01447859
22Absence seizures (HP:0002121)2.99968931
23Type 1 muscle fiber predominance (HP:0003803)2.98482780
24Abnormality of the radial head (HP:0003995)2.96545859
25Spinal rigidity (HP:0003306)2.93300938
26Broad metatarsal (HP:0001783)2.77135266
27Supranuclear gaze palsy (HP:0000605)2.75641856
28Ulnar bowing (HP:0003031)2.75356677
29Broad distal phalanx of finger (HP:0009836)2.74655086
30Amblyopia (HP:0000646)2.73921048
31Dialeptic seizures (HP:0011146)2.73541311
32Soft skin (HP:0000977)2.73335204
33Hemiplegia (HP:0002301)2.72826872
34Dysmetria (HP:0001310)2.72421124
35Abnormality of the phalanges of the hallux (HP:0010057)2.69342951
36Abnormality of the calcaneus (HP:0008364)2.67302228
37Follicular hyperkeratosis (HP:0007502)2.65483710
38Reduced subcutaneous adipose tissue (HP:0003758)2.61904134
39Short humerus (HP:0005792)2.60045044
40Depression (HP:0000716)2.60044044
41Spinal cord compression (HP:0002176)2.59233628
42Ventricular fibrillation (HP:0001663)2.57354801
43Achilles tendon contracture (HP:0001771)2.56789521
44Abnormality of the humeroradial joint (HP:0100744)2.54922489
45Testicular neoplasm (HP:0010788)2.52941319
46Mitral regurgitation (HP:0001653)2.51751938
47Coronal craniosynostosis (HP:0004440)2.51659571
48Slender build (HP:0001533)2.51330899
49Cerebral inclusion bodies (HP:0100314)2.50905460
50Genetic anticipation (HP:0003743)2.47629608
51Dysdiadochokinesis (HP:0002075)2.42114080
52Abnormality of the distal phalanges of the toes (HP:0010182)2.38835063
53Postural instability (HP:0002172)2.37974159
54Blue sclerae (HP:0000592)2.36311125
55Buphthalmos (HP:0000557)2.35683430
56Bladder diverticulum (HP:0000015)2.34663856
57Vertebral compression fractures (HP:0002953)2.34575019
58Poor eye contact (HP:0000817)2.34145995
59Wide anterior fontanel (HP:0000260)2.33639868
60Increased variability in muscle fiber diameter (HP:0003557)2.32458821
61Torticollis (HP:0000473)2.31205443
62Focal dystonia (HP:0004373)2.29692308
63Abnormality of the Achilles tendon (HP:0005109)2.29338405
64Ankle clonus (HP:0011448)2.28518296
65Dilatation of the ascending aorta (HP:0005111)2.28434444
66Anxiety (HP:0000739)2.27926598
67Abnormality of dentin (HP:0010299)2.25467242
68Aplasia/hypoplasia of the humerus (HP:0006507)2.25249534
69Cerebral aneurysm (HP:0004944)2.25186849
70Neurofibrillary tangles (HP:0002185)2.24581296
71Peritonitis (HP:0002586)2.24281364
72Ankle contracture (HP:0006466)2.23621204
73Genu recurvatum (HP:0002816)2.22527506
74Annular pancreas (HP:0001734)2.22240927
75Abnormal eating behavior (HP:0100738)2.22054003
76Joint laxity (HP:0001388)2.21363540
77Cupped ribs (HP:0000887)2.21260829
78Gaze-evoked nystagmus (HP:0000640)2.21052847
79Wormian bones (HP:0002645)2.20586403
80Difficulty climbing stairs (HP:0003551)2.19693671
81Urinary bladder sphincter dysfunction (HP:0002839)2.19581194
82Abnormal social behavior (HP:0012433)2.19169353
83Impaired social interactions (HP:0000735)2.19169353
84Aortic dissection (HP:0002647)2.18333303
85Periauricular skin pits (HP:0100277)2.17824590
86Preauricular pit (HP:0004467)2.17824590
87Lower limb amyotrophy (HP:0007210)2.17394259
88Short nail (HP:0001799)2.16965391
89Vascular tortuosity (HP:0004948)2.16324998
90Hyperacusis (HP:0010780)2.16093315
91Fragile skin (HP:0001030)2.12721233
92Sex reversal (HP:0012245)2.11329345
93Abnormal sex determination (HP:0012244)2.11329345
94Pointed chin (HP:0000307)2.10842295
95Megalencephaly (HP:0001355)2.10823961
96Gonadal dysgenesis (HP:0000133)2.10503326
97Atrophic scars (HP:0001075)2.09493813
98Aplasia involving bones of the extremities (HP:0009825)2.09207528
99Aplasia involving bones of the upper limbs (HP:0009823)2.09207528
100Aplasia of the phalanges of the hand (HP:0009802)2.09207528
101Hypoplastic left heart (HP:0004383)2.09179390
102Elbow flexion contracture (HP:0002987)2.07386973
103Urinary urgency (HP:0000012)2.06617621
104Lower limb asymmetry (HP:0100559)2.06341383
105Distal upper limb amyotrophy (HP:0007149)2.06210903
106Upper limb amyotrophy (HP:0009129)2.06210903
107Broad long bones (HP:0005622)2.05344534
108Aortic regurgitation (HP:0001659)2.05343890
109Truncal ataxia (HP:0002078)2.05309644
110Aplasia/Hypoplasia of the scapulae (HP:0006713)2.05249085
111Hypoplastic scapulae (HP:0000882)2.05249085
112Disproportionate tall stature (HP:0001519)2.04438127
113Papilledema (HP:0001085)2.03493870
114Neonatal short-limb short stature (HP:0008921)2.02834678
115Arterial tortuosity (HP:0005116)2.01941303
116Deviation of the hallux (HP:0010051)2.01575824
117Congenital glaucoma (HP:0001087)2.00305178
118Hallux valgus (HP:0001822)1.99949713
119Bowed forearm bones (HP:0003956)1.99497448
120Bowing of the arm (HP:0006488)1.99497448
121Intention tremor (HP:0002080)1.98905206
122Rapidly progressive (HP:0003678)1.98651578
123Biconcave vertebral bodies (HP:0004586)1.98555588
124Mitral valve prolapse (HP:0001634)1.98540028
125Impaired smooth pursuit (HP:0007772)1.96549153
126Dysmetric saccades (HP:0000641)1.96410821
127Turricephaly (HP:0000262)1.95640149
128Hypoventilation (HP:0002791)1.95373480
129Insomnia (HP:0100785)1.94360938
130Renal duplication (HP:0000075)1.92878996
131Mutism (HP:0002300)1.91888927
132Impaired vibratory sensation (HP:0002495)1.91440791
133Hyperextensible skin (HP:0000974)1.91415490
134Mildly elevated creatine phosphokinase (HP:0008180)1.90798296
135Broad-based gait (HP:0002136)1.90222046
136Round ear (HP:0100830)1.89891156
137Obstructive sleep apnea (HP:0002870)1.89636460
138Stereotypic behavior (HP:0000733)1.89545969
139Abnormal ventriculo-arterial connection (HP:0011563)1.89056255
140Transposition of the great arteries (HP:0001669)1.89056255
141Abnormal connection of the cardiac segments (HP:0011545)1.89056255
142Overgrowth (HP:0001548)1.88901147
143Increased connective tissue (HP:0009025)1.88840278
144Craniofacial dystonia (HP:0012179)1.87402805
145Bowel diverticulosis (HP:0005222)1.87395039
146Abnormality of the distal phalanx of the thumb (HP:0009617)1.87122695
147Broad phalanx (HP:0006009)1.86825498
148Hemiparesis (HP:0001269)1.85979696
149Hypercortisolism (HP:0001578)1.85034444
150Sudden death (HP:0001699)1.84504136
151Bronchomalacia (HP:0002780)1.83950443
152Enlarged penis (HP:0000040)1.83541113
153Flared iliac wings (HP:0002869)1.83485593
154Abnormality of skeletal muscle fiber size (HP:0012084)1.83255672
155Generalized amyotrophy (HP:0003700)1.82594541
156Bradykinesia (HP:0002067)1.81890236
157Abnormality of the pubic bones (HP:0003172)1.81836974
158Aplasia/Hypoplasia of the clavicles (HP:0006710)1.81313813
159Short middle phalanx of the 5th finger (HP:0004220)1.80796917
160Acanthosis nigricans (HP:0000956)1.80598775
161Abnormality of the humerus (HP:0003063)1.80154723
162Infantile muscular hypotonia (HP:0008947)1.76996602
163Elfin facies (HP:0004428)1.76237393
164Abnormal delivery (HP:0001787)1.72595533
165Radial bowing (HP:0002986)1.71750649
166Abnormality of carpal bone ossification (HP:0006257)1.70744393
167Insidious onset (HP:0003587)1.70477567
168Termporal pattern (HP:0011008)1.70477567
169Abnormality of the upper arm (HP:0001454)1.69728329
170Unilateral renal agenesis (HP:0000122)1.69397892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.54134872
2NTRK34.38397383
3PRKD33.50881034
4EPHA23.34132343
5MAP3K93.19379871
6EPHB22.90444445
7SIK12.59676391
8PAK62.54741435
9DAPK22.41651176
10KSR22.40683524
11MINK12.35880239
12TRIB32.15113348
13CAMKK12.12569286
14MYLK1.92859292
15NTRK11.91868554
16EPHB11.88077837
17PTK2B1.87307914
18LATS21.80220274
19LIMK11.77678177
20PLK21.76660247
21PRPF4B1.76607519
22STK381.72877469
23MAP3K41.67554509
24DDR21.66377359
25PAK41.64980778
26NME21.60141624
27ARAF1.49614514
28KSR11.49071012
29NTRK21.47880643
30CDK51.46911405
31LMTK21.42542143
32DAPK11.42351562
33MET1.36608533
34PKN21.33091709
35GRK51.31401154
36RPS6KA21.29782005
37ERBB41.28335505
38MST1R1.28010009
39PDGFRA1.27050952
40PAK31.26817109
41RIPK11.25803597
42MAP2K41.24890699
43TYRO31.24585839
44CAMK11.24371398
45RIPK41.24250168
46PRKCG1.22920742
47DMPK1.21881941
48MARK11.21766451
49MAP3K131.18422550
50IRAK31.13250417
51MAP3K21.12619948
52TAOK11.12461991
53PRKCH1.10532138
54NEK91.09417462
55AKT31.07739411
56PDK11.02949783
57SIK21.02198999
58TTN1.01831978
59BMX1.01683223
60RAF11.01095545
61MAP2K71.00735226
62MAP3K70.94627442
63PDPK10.94475137
64CAMK2A0.94449415
65CDK150.94334495
66ALK0.94051607
67CDK180.92696196
68ABL20.92590945
69RPS6KC10.92563511
70RPS6KL10.92563511
71MARK20.91484531
72CAMK2B0.91295684
73RET0.90399489
74FER0.89497094
75DAPK30.89347839
76DYRK1B0.89098874
77CDK140.84865286
78STK110.83630863
79CDK11A0.81210624
80CDK190.80399918
81MAP2K10.77225236
82LATS10.77211274
83MTOR0.76897353
84BMPR20.76262049
85PDK40.75639466
86PDK30.75639466
87DYRK1A0.75260332
88FES0.74288666
89ILK0.73580585
90RPS6KA60.73395760
91PHKG20.72743466
92PHKG10.72743466
93MAP3K30.71370736
94UHMK10.70478565
95CDK80.68583620
96MAPK130.66966386
97ERN10.66916050
98MAP3K100.66376078
99BRAF0.64158055
100MOS0.64107010
101MAP3K120.63788631
102PTK20.62576248
103PTK60.61490897
104CDC42BPA0.60761571
105PINK10.60308285
106CAMK40.59820236
107MAP3K10.58770961
108ICK0.58354054
109PAK10.57814358
110NME10.57746082
111GSK3A0.56815513
112SGK10.54498844
113BRSK10.54322626
114ROCK20.52893159
115TESK10.52650218
116CDK120.52033550
117PRKD20.49783357
118CAMK1G0.45622629
119FYN0.45355873
120RPS6KA30.45315956
121PRKG20.44798168
122PAK20.44499368
123CAMK2D0.44060443
124ROCK10.43339322
125NEK10.42850945
126SGK30.41541124
127MUSK0.41519734
128MAP3K110.41417131
129PRKCE0.39650638
130TAOK20.39416809
131NEK60.39380050
132PRKCZ0.38545630
133SGK4940.38221144
134SGK2230.38221144
135LRRK20.37884779
136ADRBK10.35589016
137CAMK2G0.35185753
138SRC0.34553063
139CDK90.34491945
140PRKD10.34365697
141PDGFRB0.33713497
142CDK40.31719885

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.94285086
2Synaptic vesicle cycle_Homo sapiens_hsa047212.67464642
3Long-term potentiation_Homo sapiens_hsa047202.60988186
4Circadian entrainment_Homo sapiens_hsa047132.58745374
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.44228091
6Olfactory transduction_Homo sapiens_hsa047402.38326811
7Glutamatergic synapse_Homo sapiens_hsa047242.32434207
8Amphetamine addiction_Homo sapiens_hsa050312.25083602
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19915543
10Aldosterone synthesis and secretion_Homo sapiens_hsa049252.10171610
11* Salivary secretion_Homo sapiens_hsa049702.05791656
12Gastric acid secretion_Homo sapiens_hsa049712.00972813
13GABAergic synapse_Homo sapiens_hsa047272.00646831
14Hippo signaling pathway_Homo sapiens_hsa043901.97374400
15Insulin secretion_Homo sapiens_hsa049111.94504231
16Basal cell carcinoma_Homo sapiens_hsa052171.91472864
17Morphine addiction_Homo sapiens_hsa050321.86920591
18Cholinergic synapse_Homo sapiens_hsa047251.76100564
19* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75969060
20Dopaminergic synapse_Homo sapiens_hsa047281.75180326
21Oxytocin signaling pathway_Homo sapiens_hsa049211.71923478
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.60258102
23Glioma_Homo sapiens_hsa052141.56542265
24* Calcium signaling pathway_Homo sapiens_hsa040201.56512576
25GnRH signaling pathway_Homo sapiens_hsa049121.56285521
26Nitrogen metabolism_Homo sapiens_hsa009101.50392765
27Renin secretion_Homo sapiens_hsa049241.36217342
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35896361
29Vitamin B6 metabolism_Homo sapiens_hsa007501.34142157
30Other glycan degradation_Homo sapiens_hsa005111.34132513
31Long-term depression_Homo sapiens_hsa047301.33742405
32Dilated cardiomyopathy_Homo sapiens_hsa054141.29596087
33Thyroid cancer_Homo sapiens_hsa052161.26744702
34Hedgehog signaling pathway_Homo sapiens_hsa043401.26727365
35cAMP signaling pathway_Homo sapiens_hsa040241.25727403
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25656832
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24568304
38Estrogen signaling pathway_Homo sapiens_hsa049151.22012403
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21360920
40Gap junction_Homo sapiens_hsa045401.19791472
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18110208
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17626978
43Adherens junction_Homo sapiens_hsa045201.17228301
44Melanogenesis_Homo sapiens_hsa049161.16731811
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15722473
46Taste transduction_Homo sapiens_hsa047421.14055156
47Type II diabetes mellitus_Homo sapiens_hsa049301.14046608
48* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13055660
49Axon guidance_Homo sapiens_hsa043601.11066053
50MicroRNAs in cancer_Homo sapiens_hsa052061.10848654
51Cocaine addiction_Homo sapiens_hsa050301.07672442
52Serotonergic synapse_Homo sapiens_hsa047261.03589857
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01389622
54ErbB signaling pathway_Homo sapiens_hsa040120.99606737
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.99011188
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.98158222
57Cardiac muscle contraction_Homo sapiens_hsa042600.96024863
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94570421
59Tight junction_Homo sapiens_hsa045300.94463137
60* Vascular smooth muscle contraction_Homo sapiens_hsa042700.94349896
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92139488
62Melanoma_Homo sapiens_hsa052180.90122262
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89724080
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87403380
65TGF-beta signaling pathway_Homo sapiens_hsa043500.86934393
66VEGF signaling pathway_Homo sapiens_hsa043700.86908978
67Thyroid hormone synthesis_Homo sapiens_hsa049180.86838150
68Glucagon signaling pathway_Homo sapiens_hsa049220.85944291
69Pathways in cancer_Homo sapiens_hsa052000.83278827
70Chronic myeloid leukemia_Homo sapiens_hsa052200.82773831
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80182153
72Pancreatic secretion_Homo sapiens_hsa049720.79000085
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77771090
74Endometrial cancer_Homo sapiens_hsa052130.76099679
75Collecting duct acid secretion_Homo sapiens_hsa049660.76079094
76Rap1 signaling pathway_Homo sapiens_hsa040150.75820197
77AMPK signaling pathway_Homo sapiens_hsa041520.75299964
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73918183
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72483302
80Sphingolipid metabolism_Homo sapiens_hsa006000.71612887
81Focal adhesion_Homo sapiens_hsa045100.70928274
82Oocyte meiosis_Homo sapiens_hsa041140.70798955
83Choline metabolism in cancer_Homo sapiens_hsa052310.70250203
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69888531
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.68466104
86MAPK signaling pathway_Homo sapiens_hsa040100.65632606
87N-Glycan biosynthesis_Homo sapiens_hsa005100.65369401
88Small cell lung cancer_Homo sapiens_hsa052220.65135730
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64922315
90Endocytosis_Homo sapiens_hsa041440.64888227
91Dorso-ventral axis formation_Homo sapiens_hsa043200.64426368
92Notch signaling pathway_Homo sapiens_hsa043300.63558608
93Bile secretion_Homo sapiens_hsa049760.62611082
94Vibrio cholerae infection_Homo sapiens_hsa051100.62540525
95mTOR signaling pathway_Homo sapiens_hsa041500.59123265
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58747332
97ECM-receptor interaction_Homo sapiens_hsa045120.58135047
98Ras signaling pathway_Homo sapiens_hsa040140.57907142
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57901168
100Proteoglycans in cancer_Homo sapiens_hsa052050.57686639
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55368823
102Pancreatic cancer_Homo sapiens_hsa052120.54848803
103Amoebiasis_Homo sapiens_hsa051460.54601502
104Fatty acid biosynthesis_Homo sapiens_hsa000610.54443948
105Bladder cancer_Homo sapiens_hsa052190.53855365
106Non-small cell lung cancer_Homo sapiens_hsa052230.52015740
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.51999801
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51994039
109Renal cell carcinoma_Homo sapiens_hsa052110.51854336
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51801491
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51256648
112Wnt signaling pathway_Homo sapiens_hsa043100.51204989
113Galactose metabolism_Homo sapiens_hsa000520.50683101
114* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49949103
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.45942070
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45528437
117HIF-1 signaling pathway_Homo sapiens_hsa040660.44980909
118Insulin signaling pathway_Homo sapiens_hsa049100.44707805
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43802779
120Prion diseases_Homo sapiens_hsa050200.42575244
121African trypanosomiasis_Homo sapiens_hsa051430.41861357
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.41766909
123Inositol phosphate metabolism_Homo sapiens_hsa005620.41221637
124Ovarian steroidogenesis_Homo sapiens_hsa049130.40986856
125Platelet activation_Homo sapiens_hsa046110.39744056
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39404292
127Protein digestion and absorption_Homo sapiens_hsa049740.37177240

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