ADRA2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.46911360
2Golgi transport vesicle coating (GO:0048200)6.46911360
3triglyceride catabolic process (GO:0019433)6.13534757
4low-density lipoprotein particle clearance (GO:0034383)5.66609841
5endocrine pancreas development (GO:0031018)5.55040739
6type B pancreatic cell development (GO:0003323)5.44758380
7neutral lipid catabolic process (GO:0046461)5.44179186
8acylglycerol catabolic process (GO:0046464)5.44179186
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.99124837
10regulation of sequestering of triglyceride (GO:0010889)4.91214011
11protein maturation by protein folding (GO:0022417)4.81239334
12transcytosis (GO:0045056)4.73681783
13protein heterotrimerization (GO:0070208)4.72868495
14insulin secretion (GO:0030073)4.71975488
15peptide hormone processing (GO:0016486)4.66365132
16glandular epithelial cell development (GO:0002068)4.59138096
17response to dietary excess (GO:0002021)4.29223820
18regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.27301793
19regulation of type B pancreatic cell apoptotic process (GO:2000674)4.25952957
20protein retention in ER lumen (GO:0006621)4.20279343
21glandular epithelial cell differentiation (GO:0002067)4.20124639
22ethanol oxidation (GO:0006069)4.14531430
23detection of calcium ion (GO:0005513)4.07441119
24cerebellar Purkinje cell layer development (GO:0021680)3.96835378
25retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.95316831
26regulation of gonadotropin secretion (GO:0032276)3.94331488
27glycerolipid catabolic process (GO:0046503)3.94009276
28activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.93407701
29cellular response to vitamin (GO:0071295)3.91059358
30positive regulation of insulin secretion (GO:0032024)3.87020144
31extracellular fibril organization (GO:0043206)3.83169474
32COPII vesicle coating (GO:0048208)3.80423692
33negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.74143004
34fatty acid homeostasis (GO:0055089)3.69262674
35* regulation of insulin secretion (GO:0050796)3.68486583
36positive regulation of nuclease activity (GO:0032075)3.67871370
37ER overload response (GO:0006983)3.66453480
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.65743142
39ovulation from ovarian follicle (GO:0001542)3.63918560
40nitric oxide mediated signal transduction (GO:0007263)3.63704492
41glomerular filtration (GO:0003094)3.59852318
42peptide hormone secretion (GO:0030072)3.53713625
43columnar/cuboidal epithelial cell development (GO:0002066)3.52205419
44membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.51606377
45ethanol metabolic process (GO:0006067)3.48212960
46peptide secretion (GO:0002790)3.48154056
47primary alcohol catabolic process (GO:0034310)3.47436984
48positive regulation of glycolytic process (GO:0045821)3.46355088
49protein targeting to Golgi (GO:0000042)3.44390295
50cellular response to leptin stimulus (GO:0044320)3.44266048
51white fat cell differentiation (GO:0050872)3.42096153
52cellular response to vitamin D (GO:0071305)3.40828411
53protein localization to cell surface (GO:0034394)3.38637957
54exocrine pancreas development (GO:0031017)3.37206057
55* regulation of peptide hormone secretion (GO:0090276)3.35198304
56regulation of short-term neuronal synaptic plasticity (GO:0048172)3.34929135
57CDP-diacylglycerol biosynthetic process (GO:0016024)3.33971008
58regulation of nuclease activity (GO:0032069)3.32692412
59cell migration involved in heart development (GO:0060973)3.32074342
60* regulation of peptide secretion (GO:0002791)3.31114455
61lipid particle organization (GO:0034389)3.28447544
62CDP-diacylglycerol metabolic process (GO:0046341)3.27656979
63sequestering of metal ion (GO:0051238)3.27458238
64vesicle coating (GO:0006901)3.24749106
65polyol transport (GO:0015791)3.24573810
66barbed-end actin filament capping (GO:0051016)3.24561592
67lipid storage (GO:0019915)3.24164923
68regulation of integrin-mediated signaling pathway (GO:2001044)3.23325897
69endoplasmic reticulum unfolded protein response (GO:0030968)3.23277881
70regulation of lipoprotein metabolic process (GO:0050746)3.22895419
71synaptic vesicle maturation (GO:0016188)3.21766689
72negative regulation of response to food (GO:0032096)3.20359814
73negative regulation of appetite (GO:0032099)3.20359814
74fibril organization (GO:0097435)3.15966270
75positive regulation of peptide hormone secretion (GO:0090277)3.15427099
76cellular response to unfolded protein (GO:0034620)3.14838481
77response to leptin (GO:0044321)3.14229619
78inner ear receptor cell development (GO:0060119)3.13450491
79membrane repolarization during action potential (GO:0086011)3.11822509
80negative regulation of gluconeogenesis (GO:0045721)3.11132409
81positive regulation of peptide secretion (GO:0002793)3.10344381
82diacylglycerol metabolic process (GO:0046339)3.10232543
83renal filtration (GO:0097205)3.08547064
84chemosensory behavior (GO:0007635)3.05794001
85cGMP-mediated signaling (GO:0019934)3.05543265
86positive regulation of insulin receptor signaling pathway (GO:0046628)3.04716663
87negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.04261509
88ER-nucleus signaling pathway (GO:0006984)3.04022636
89primary alcohol metabolic process (GO:0034308)3.00891614
90establishment of protein localization to Golgi (GO:0072600)3.00606833
91negative regulation of amino acid transport (GO:0051956)3.00083610
92regulation of cAMP-dependent protein kinase activity (GO:2000479)2.99591365
93cellular response to topologically incorrect protein (GO:0035967)2.98764831
94negative regulation of macrophage differentiation (GO:0045650)2.98510541
95positive regulation of cellular response to insulin stimulus (GO:1900078)2.98451171
96macroautophagy (GO:0016236)2.98151910
97signal peptide processing (GO:0006465)2.97994061
98regulation of synaptic vesicle exocytosis (GO:2000300)2.97372678
99regulation of beta-amyloid formation (GO:1902003)2.97254218
100positive regulation of glomerulus development (GO:0090193)2.97228341
101astrocyte differentiation (GO:0048708)2.93568802
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.93336595
103cellular response to glucagon stimulus (GO:0071377)2.92797780
104relaxation of cardiac muscle (GO:0055119)2.92776872
105cellular response to epinephrine stimulus (GO:0071872)2.92148062
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91571266
107ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.91126098
108* regulation of hormone secretion (GO:0046883)2.87629349
109negative regulation of bone resorption (GO:0045779)2.82540395
110proline transport (GO:0015824)2.81051269
111activation of protein kinase A activity (GO:0034199)2.80945850
112retrograde transport, vesicle recycling within Golgi (GO:0000301)2.80888591
113retinol metabolic process (GO:0042572)2.80446172
114positive regulation of fatty acid beta-oxidation (GO:0032000)2.79990922
115negative regulation of smooth muscle cell migration (GO:0014912)2.79783338
116peptide transport (GO:0015833)2.79279226
117suckling behavior (GO:0001967)2.76559797
118epithelial cell fate commitment (GO:0072148)2.75508408
119regulation of Golgi to plasma membrane protein transport (GO:0042996)2.75449227
120cell communication by electrical coupling (GO:0010644)2.72824208
121positive regulation of metanephros development (GO:0072216)2.71854612
122positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.71337835
123NADH metabolic process (GO:0006734)2.70367517
124negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69945090
125* regulation of peptide transport (GO:0090087)2.69437847
126regulation of macrophage derived foam cell differentiation (GO:0010743)2.69047397
127alanine transport (GO:0032328)2.68388808
128response to endoplasmic reticulum stress (GO:0034976)2.68285808
129triglyceride biosynthetic process (GO:0019432)2.68135031
130eosinophil chemotaxis (GO:0048245)2.68045593
131regulation of amyloid precursor protein catabolic process (GO:1902991)2.68006190
132negative regulation of granulocyte differentiation (GO:0030853)2.66906650
133hormone secretion (GO:0046879)2.66838746
134positive regulation of fatty acid oxidation (GO:0046321)2.66554016
135positive regulation of receptor recycling (GO:0001921)2.66407401
136regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.66250425
137interleukin-1-mediated signaling pathway (GO:0070498)2.65792730
138keratan sulfate catabolic process (GO:0042340)2.64818886
139* regulation of calcium ion-dependent exocytosis (GO:0017158)2.64407583
140protein localization to Golgi apparatus (GO:0034067)2.64096851
141locomotory exploration behavior (GO:0035641)2.63948468
142positive regulation of glucose import (GO:0046326)2.62495011
143triglyceride metabolic process (GO:0006641)2.62463846
144neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.61781766
145potassium ion import (GO:0010107)2.61144765
146nucleoside diphosphate catabolic process (GO:0009134)2.60535787
147intra-Golgi vesicle-mediated transport (GO:0006891)2.60083123
148synaptic vesicle exocytosis (GO:0016079)2.58758938
149regulation of synaptic vesicle transport (GO:1902803)2.58358056
150negative regulation of metanephros development (GO:0072217)2.57082152
151regulation of glucocorticoid secretion (GO:2000849)2.56317112
152regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.56203284
153acylglycerol biosynthetic process (GO:0046463)2.56045903
154neutral lipid biosynthetic process (GO:0046460)2.56045903
155toxin metabolic process (GO:0009404)2.55328364
156brown fat cell differentiation (GO:0050873)2.54719974
157negative regulation of cartilage development (GO:0061037)2.54581051
158negative regulation of tissue remodeling (GO:0034104)2.54333374
159extracellular matrix assembly (GO:0085029)2.54276629
160L-alpha-amino acid transmembrane transport (GO:1902475)2.52320625
161phosphatidic acid biosynthetic process (GO:0006654)2.52003606
162phosphatidic acid metabolic process (GO:0046473)2.52003606
163innervation (GO:0060384)2.51864119
164cellular potassium ion homeostasis (GO:0030007)2.51841881
165signal release (GO:0023061)2.49398973
166pancreas development (GO:0031016)2.49263070
167somite development (GO:0061053)2.49028516
168hormone transport (GO:0009914)2.49010122
169induction of positive chemotaxis (GO:0050930)2.48604503
170vascular endothelial growth factor signaling pathway (GO:0038084)2.48319379
171cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.47933314
172positive regulation of hormone secretion (GO:0046887)2.47878383
173response to unfolded protein (GO:0006986)2.47452729
174retina vasculature morphogenesis in camera-type eye (GO:0061299)2.47230193
175regulation of glycogen (starch) synthase activity (GO:2000465)2.45204907
176angiogenesis involved in wound healing (GO:0060055)2.44879779
177negative regulation of glycogen biosynthetic process (GO:0045719)2.44644649
178positive regulation of endothelial cell apoptotic process (GO:2000353)2.43964878
179sodium ion export (GO:0071436)2.43870135
180response to epinephrine (GO:0071871)2.43532234
181metanephric mesenchyme development (GO:0072075)2.43178468
182adult feeding behavior (GO:0008343)2.41040347
183positive regulation of vasculogenesis (GO:2001214)2.40881667
184short-term memory (GO:0007614)2.40739779
185negative regulation of protein autophosphorylation (GO:0031953)2.39617426
186acylglycerol metabolic process (GO:0006639)2.39400389
187neutral lipid metabolic process (GO:0006638)2.39237615
188negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.38795618
189positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.38528499
190positive regulation of glycogen biosynthetic process (GO:0045725)2.36297660
191polyketide metabolic process (GO:0030638)2.36064665
192doxorubicin metabolic process (GO:0044598)2.36064665
193daunorubicin metabolic process (GO:0044597)2.36064665
194regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.35062433
195response to vitamin E (GO:0033197)2.31123598
196positive regulation of glucose transport (GO:0010828)2.30700550
197glycerol metabolic process (GO:0006071)2.30696438
198endothelium development (GO:0003158)2.28871442

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.72074402
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.49623963
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.85225135
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49543268
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44625742
6* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35639538
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.34027412
8* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25266818
9* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14717616
10* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12888922
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10604488
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.09948095
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07906576
14GATA1_22025678_ChIP-Seq_K562_Human2.06518406
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98765080
16GBX2_23144817_ChIP-Seq_PC3_Human1.98459138
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97188328
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95144685
19DROSHA_22980978_ChIP-Seq_HELA_Human1.94863103
20* EZH2_27304074_Chip-Seq_ESCs_Mouse1.94257385
21* EZH2_27294783_Chip-Seq_ESCs_Mouse1.93746979
22NR3C1_23031785_ChIP-Seq_PC12_Mouse1.90289631
23* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84784640
24* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84784640
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84390898
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.83250718
27* RNF2_27304074_Chip-Seq_ESCs_Mouse1.76715948
28* REST_18959480_ChIP-ChIP_MESCs_Mouse1.72819660
29IGF1R_20145208_ChIP-Seq_DFB_Human1.71457698
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.60638210
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57048427
32ZNF274_21170338_ChIP-Seq_K562_Hela1.54154031
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52919087
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52251190
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42360754
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.42189300
37BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42012253
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.41602076
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41064174
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.40525839
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40495221
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39622398
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36844145
44CLOCK_20551151_ChIP-Seq_293T_Human1.36679637
45* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35307753
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31629963
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31629963
48SMAD4_21799915_ChIP-Seq_A2780_Human1.29039903
49PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.27960329
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.26999277
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25784452
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23926148
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.23888446
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23437230
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22366184
56CJUN_26792858_Chip-Seq_BT549_Human1.22173785
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.21844206
58* PIAS1_25552417_ChIP-Seq_VCAP_Human1.21485110
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19778349
60STAT3_23295773_ChIP-Seq_U87_Human1.19149206
61* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18071642
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17481477
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16044667
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15860370
65* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15452374
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.15144193
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14976443
68BCAT_22108803_ChIP-Seq_LS180_Human1.13597747
69* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13226328
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.12477802
71RXR_22158963_ChIP-Seq_LIVER_Mouse1.12474050
72* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10503655
73* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10461803
74* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08816968
75AR_19668381_ChIP-Seq_PC3_Human1.07656264
76* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07656216
77* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07595341
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07117182
79RXR_22108803_ChIP-Seq_LS180_Human1.05592383
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.04858688
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04857203
82KDM2B_26808549_Chip-Seq_K562_Human1.04281407
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03803492
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01521885
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01218108
86* SMAD3_21741376_ChIP-Seq_ESCs_Human1.01196229
87* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99114954
88SMAD3_21741376_ChIP-Seq_EPCs_Human0.99073350
89* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98760219
90* RING1B_27294783_Chip-Seq_ESCs_Mouse0.98589386
91* TP53_20018659_ChIP-ChIP_R1E_Mouse0.97923546
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97069303
93* SOX2_20726797_ChIP-Seq_SW620_Human0.96543333
94TCF4_18268006_ChIP-ChIP_LS174T_Human0.96253556
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95726101
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95322488
97* P300_19829295_ChIP-Seq_ESCs_Human0.95295100
98* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95009770
99* AR_25329375_ChIP-Seq_VCAP_Human0.94769686
100AHR_22903824_ChIP-Seq_MCF-7_Human0.94768509
101* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94711568
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94680935
103VDR_22108803_ChIP-Seq_LS180_Human0.94664127
104* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94368967
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93957957
106RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93236948
107EP300_21415370_ChIP-Seq_HL-1_Mouse0.92942506
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91255756
109* TCF4_23295773_ChIP-Seq_U87_Human0.91209297
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91007456
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90953589
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90518211
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89423668
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.89376260
115TBX20_22080862_ChIP-Seq_HEART_Mouse0.89376260
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89176568
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.88265707
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88009527
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87521010
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.87296546
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86573859
122POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86238331
123NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84485049
124PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83973888
125TET1_21490601_ChIP-Seq_MESCs_Mouse0.83876353
126PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.83653317
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83370582
128RUNX2_22187159_ChIP-Seq_PCA_Human0.83171391
129RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83022716
130* RING1B_27294783_Chip-Seq_NPCs_Mouse0.82806062
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82631627
132* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80944778
133SA1_22415368_ChIP-Seq_MEFs_Mouse0.80751403
134WT1_19549856_ChIP-ChIP_CCG9911_Human0.80711901
135TP53_18474530_ChIP-ChIP_U2OS_Human0.80246219
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80189559
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80188011
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80095636
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79892431
140* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78807896
141CTCF_27219007_Chip-Seq_Bcells_Human0.78806086
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.78480188
143DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78164128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.84151444
2MP0005670_abnormal_white_adipose5.64778328
3MP0002909_abnormal_adrenal_gland4.14372492
4MP0009780_abnormal_chondrocyte_physiolo4.09764718
5MP0008438_abnormal_cutaneous_collagen3.91010278
6MP0002877_abnormal_melanocyte_morpholog3.90435533
7MP0004043_abnormal_pH_regulation3.84083303
8MP0005666_abnormal_adipose_tissue3.83380118
9MP0002693_abnormal_pancreas_physiology3.46190882
10MP0005275_abnormal_skin_tensile3.42426264
11MP0010386_abnormal_urinary_bladder3.19110565
12MP0001944_abnormal_pancreas_morphology3.10085346
13MP0004130_abnormal_muscle_cell3.02159402
14MP0002971_abnormal_brown_adipose3.01587470
15MP0000013_abnormal_adipose_tissue2.86096215
16MP0000678_abnormal_parathyroid_gland2.77782111
17MP0004270_analgesia2.67769053
18MP0005379_endocrine/exocrine_gland_phen2.47126174
19MP0003279_aneurysm2.29323487
20MP0010329_abnormal_lipoprotein_level2.10733190
21MP0001986_abnormal_taste_sensitivity2.09297486
22MP0009115_abnormal_fat_cell2.03030773
23MP0002108_abnormal_muscle_morphology2.02538609
24MP0004185_abnormal_adipocyte_glucose2.01407893
25MP0002295_abnormal_pulmonary_circulatio1.99607660
26MP0003195_calcinosis1.98845235
27MP0004272_abnormal_basement_membrane1.96062686
28MP0004859_abnormal_synaptic_plasticity1.91475540
29MP0006072_abnormal_retinal_apoptosis1.86156478
30MP0003705_abnormal_hypodermis_morpholog1.83753832
31MP0000462_abnormal_digestive_system1.82369110
32* MP0002078_abnormal_glucose_homeostasis1.81184653
33MP0005646_abnormal_pituitary_gland1.80628702
34* MP0003635_abnormal_synaptic_transmissio1.78397533
35MP0006138_congestive_heart_failure1.76964919
36MP0002138_abnormal_hepatobiliary_system1.74603907
37MP0005220_abnormal_exocrine_pancreas1.73814161
38MP0002970_abnormal_white_adipose1.71136413
39MP0003186_abnormal_redox_activity1.69578457
40MP0003724_increased_susceptibility_to1.68948643
41MP0002638_abnormal_pupillary_reflex1.68196373
42MP0002822_catalepsy1.67195923
43MP0003122_maternal_imprinting1.66578373
44MP0003300_gastrointestinal_ulcer1.66083658
45MP0002734_abnormal_mechanical_nocicepti1.65488000
46MP0004858_abnormal_nervous_system1.63806348
47MP0009384_cardiac_valve_regurgitation1.62664229
48MP0003183_abnormal_peptide_metabolism1.62007302
49MP0005645_abnormal_hypothalamus_physiol1.61292569
50MP0003011_delayed_dark_adaptation1.59691174
51MP0005334_abnormal_fat_pad1.57689530
52MP0002896_abnormal_bone_mineralization1.53633471
53MP0001879_abnormal_lymphatic_vessel1.53349055
54MP0004145_abnormal_muscle_electrophysio1.51683380
55MP0001765_abnormal_ion_homeostasis1.49992494
56MP0002234_abnormal_pharynx_morphology1.47912143
57MP0005423_abnormal_somatic_nervous1.46601647
58MP0000751_myopathy1.43704728
59MP0000003_abnormal_adipose_tissue1.41365317
60MP0003868_abnormal_feces_composition1.40249693
61MP0002837_dystrophic_cardiac_calcinosis1.40197823
62MP0001958_emphysema1.40049018
63MP0000613_abnormal_salivary_gland1.38080540
64MP0002733_abnormal_thermal_nociception1.33904990
65MP0002118_abnormal_lipid_homeostasis1.32000808
66MP0005508_abnormal_skeleton_morphology1.31631530
67MP0008961_abnormal_basal_metabolism1.30230405
68MP0003879_abnormal_hair_cell1.29144219
69MP0003828_pulmonary_edema1.28784452
70MP0001501_abnormal_sleep_pattern1.28516076
71MP0002063_abnormal_learning/memory/cond1.28394112
72MP0002572_abnormal_emotion/affect_behav1.26778096
73MP0005503_abnormal_tendon_morphology1.26489719
74MP0002876_abnormal_thyroid_physiology1.23827717
75MP0003953_abnormal_hormone_level1.19660299
76MP0010368_abnormal_lymphatic_system1.19103787
77MP0001299_abnormal_eye_distance/1.18990334
78MP0005595_abnormal_vascular_smooth1.18723763
79MP0009745_abnormal_behavioral_response1.17997296
80MP0003880_abnormal_central_pattern1.16446228
81MP0001348_abnormal_lacrimal_gland1.16018203
82MP0003690_abnormal_glial_cell1.15300211
83MP0001970_abnormal_pain_threshold1.13968687
84MP0002064_seizures1.13598837
85MP0000631_abnormal_neuroendocrine_gland1.09510014
86MP0000372_irregular_coat_pigmentation1.08603798
87MP0005167_abnormal_blood-brain_barrier1.06083856
88MP0004264_abnormal_extraembryonic_tissu1.05330960
89MP0005452_abnormal_adipose_tissue1.04397379
90MP0003172_abnormal_lysosome_physiology1.04315697
91MP0006054_spinal_hemorrhage1.04158343
92MP0005535_abnormal_body_temperature1.03766818
93MP0002557_abnormal_social/conspecific_i1.02418249
94MP0006276_abnormal_autonomic_nervous1.01367050
95MP0002272_abnormal_nervous_system1.01308537
96MP0001440_abnormal_grooming_behavior1.00922875
97MP0000955_abnormal_spinal_cord1.00847188
98MP0004885_abnormal_endolymph1.00392068
99MP0002933_joint_inflammation1.00017587
100MP0005409_darkened_coat_color0.99899047
101MP0003329_amyloid_beta_deposits0.98684281
102MP0000767_abnormal_smooth_muscle0.96518548
103MP0005058_abnormal_lysosome_morphology0.96503330
104MP0003950_abnormal_plasma_membrane0.96446466
105MP0000249_abnormal_blood_vessel0.95944469
106MP0000343_altered_response_to0.95937711
107MP0005310_abnormal_salivary_gland0.94840499
108MP0005257_abnormal_intraocular_pressure0.94034085
109MP0005171_absent_coat_pigmentation0.93292639
110MP0003866_abnormal_defecation0.91667822
111MP0001270_distended_abdomen0.91031294
112MP0003633_abnormal_nervous_system0.90349228
113MP0000538_abnormal_urinary_bladder0.89140871
114MP0003634_abnormal_glial_cell0.87869587
115MP0005164_abnormal_response_to0.87646263
116MP0001502_abnormal_circadian_rhythm0.86347452
117MP0005385_cardiovascular_system_phenoty0.84953542
118MP0001544_abnormal_cardiovascular_syste0.84953542
119MP0003787_abnormal_imprinting0.84045957
120MP0002928_abnormal_bile_duct0.83234069
121MP0002102_abnormal_ear_morphology0.82359931
122MP0005187_abnormal_penis_morphology0.81878849
123MP0002067_abnormal_sensory_capabilities0.80691174
124MP0005253_abnormal_eye_physiology0.80233712
125MP0005165_increased_susceptibility_to0.79896265
126MP0002069_abnormal_eating/drinking_beha0.79650669
127MP0003045_fibrosis0.79351292
128MP0004924_abnormal_behavior0.79119714
129MP0005386_behavior/neurological_phenoty0.79119714
130MP0001664_abnormal_digestion0.78282485
131MP0001542_abnormal_bone_strength0.78150799
132MP0003959_abnormal_lean_body0.77711412
133MP0008569_lethality_at_weaning0.77269681
134MP0000566_synostosis0.76547696
135MP0001968_abnormal_touch/_nociception0.75423603
136MP0002133_abnormal_respiratory_system0.75253438
137MP0005388_respiratory_system_phenotype0.75253438
138MP0001177_atelectasis0.74986916
139MP0004215_abnormal_myocardial_fiber0.73120443
140MP0001661_extended_life_span0.72957257
141MP0009672_abnormal_birth_weight0.70560530
142MP0009250_abnormal_appendicular_skeleto0.69761851
143MP0000759_abnormal_skeletal_muscle0.69048638
144MP0001984_abnormal_olfaction0.68361932
145MP0002249_abnormal_larynx_morphology0.67650687
146MP0002115_abnormal_skeleton_extremities0.67019232
147MP0005375_adipose_tissue_phenotype0.66548030
148MP0009643_abnormal_urine_homeostasis0.66494313
149MP0002066_abnormal_motor_capabilities/c0.66005210
150MP0009703_decreased_birth_body0.65595249
151MP0005448_abnormal_energy_balance0.65506673
152MP0005647_abnormal_sex_gland0.65479475
153MP0003948_abnormal_gas_homeostasis0.65303565
154MP0001486_abnormal_startle_reflex0.65210118
155MP0001756_abnormal_urination0.65153928
156MP0002229_neurodegeneration0.64938901
157MP0000163_abnormal_cartilage_morphology0.64825571
158* MP0000230_abnormal_systemic_arterial0.64708869
159MP0002090_abnormal_vision0.64062854
160MP0005390_skeleton_phenotype0.61151212
161MP0008004_abnormal_stomach_pH0.57500459
162MP0002735_abnormal_chemical_nociception0.56464142
163MP0000534_abnormal_ureter_morphology0.56179511
164MP0003075_altered_response_to0.56138606
165MP0002128_abnormal_blood_circulation0.54827958

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.19388271
2Hyperinsulinemic hypoglycemia (HP:0000825)6.62729112
3Hypoglycemic seizures (HP:0002173)5.75393617
4Protrusio acetabuli (HP:0003179)5.56427007
5Symptomatic seizures (HP:0011145)5.43299735
6Oligomenorrhea (HP:0000876)4.92179173
7Abnormality of calcium-phosphate metabolism (HP:0100530)4.76303624
8Acanthosis nigricans (HP:0000956)4.54774654
9Insulin-resistant diabetes mellitus (HP:0000831)4.39947925
10Large for gestational age (HP:0001520)4.23073408
11Hypoglycemic coma (HP:0001325)4.18337573
12Decreased circulating renin level (HP:0003351)4.15986335
13Hyperglycemia (HP:0003074)4.01611904
14Aortic aneurysm (HP:0004942)3.96254672
15Broad metatarsal (HP:0001783)3.88601069
16Abnormality of the pancreatic islet cells (HP:0006476)3.83618161
17Abnormality of endocrine pancreas physiology (HP:0012093)3.83618161
18Vascular tortuosity (HP:0004948)3.71445794
19Hypertriglyceridemia (HP:0002155)3.66528541
20Ketoacidosis (HP:0001993)3.66204964
21Late onset (HP:0003584)3.55058660
22Agitation (HP:0000713)3.53485458
23Hyperparathyroidism (HP:0000843)3.51087416
24Mucopolysacchariduria (HP:0008155)3.48284546
25Urinary glycosaminoglycan excretion (HP:0003541)3.48284546
26Pancreatic islet-cell hyperplasia (HP:0004510)3.44383445
27Hyperlipoproteinemia (HP:0010980)3.40627571
28Hypokalemia (HP:0002900)3.35129883
29Dysostosis multiplex (HP:0000943)3.34582619
30Papilledema (HP:0001085)3.24564730
31Premature rupture of membranes (HP:0001788)3.20369768
32Increased variability in muscle fiber diameter (HP:0003557)3.18789621
33Soft skin (HP:0000977)3.12992989
34Abnormality of polysaccharide metabolism (HP:0011012)3.08072290
35Abnormality of glycosaminoglycan metabolism (HP:0004371)3.08072290
36Abnormality of mucopolysaccharide metabolism (HP:0011020)3.08072290
37Abnormality of renin-angiotensin system (HP:0000847)3.06374432
38Arterial tortuosity (HP:0005116)3.03763557
39Abnormal pancreas size (HP:0012094)3.03723084
40Bone cyst (HP:0012062)2.91272897
41Spinal rigidity (HP:0003306)2.87647158
42Cerebral aneurysm (HP:0004944)2.86966160
43EEG with generalized epileptiform discharges (HP:0011198)2.81116692
44Visual hallucinations (HP:0002367)2.78720223
45Abnormal eating behavior (HP:0100738)2.76692673
46Hypsarrhythmia (HP:0002521)2.76576142
47Lymphangioma (HP:0100764)2.74725207
48Hypercortisolism (HP:0001578)2.73299604
49Absent/shortened dynein arms (HP:0200106)2.72083672
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.72083672
51Epileptiform EEG discharges (HP:0011182)2.72029819
52Coronal craniosynostosis (HP:0004440)2.70385796
53Abnormality of potassium homeostasis (HP:0011042)2.69232749
54Shallow orbits (HP:0000586)2.68412529
55Overgrowth (HP:0001548)2.65278377
56Hyperkalemia (HP:0002153)2.63479203
57Abnormal respiratory epithelium morphology (HP:0012253)2.63202200
58Abnormal respiratory motile cilium morphology (HP:0005938)2.63202200
59Polyphagia (HP:0002591)2.62087086
60Hyperactive renin-angiotensin system (HP:0000841)2.61473016
61Prolonged bleeding time (HP:0003010)2.61094067
62Long foot (HP:0001833)2.61035024
63Hyperventilation (HP:0002883)2.59746947
64Aortic dissection (HP:0002647)2.59196636
65Retinal atrophy (HP:0001105)2.58911288
66Pheochromocytoma (HP:0002666)2.58046112
67Unilateral renal agenesis (HP:0000122)2.57971980
68Ankle contracture (HP:0006466)2.57312202
69Osteomalacia (HP:0002749)2.54397618
70Muscle fiber splitting (HP:0003555)2.53077540
71Abnormal ciliary motility (HP:0012262)2.52706254
72Increased circulating renin level (HP:0000848)2.49989512
73Striae distensae (HP:0001065)2.49619420
74Conjugated hyperbilirubinemia (HP:0002908)2.48771550
75Increased mean platelet volume (HP:0011877)2.47271871
76Vertebral compression fractures (HP:0002953)2.46544820
77Follicular hyperkeratosis (HP:0007502)2.46123474
78Supranuclear gaze palsy (HP:0000605)2.45980299
79Abnormality of skeletal muscle fiber size (HP:0012084)2.45235864
80Hypoplasia of the iris (HP:0007676)2.36634424
81Cervical subluxation (HP:0003308)2.36398008
82Prominent supraorbital ridges (HP:0000336)2.34881772
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34700049
84Rhinitis (HP:0012384)2.34651319
85Growth hormone excess (HP:0000845)2.34116592
86Insulin resistance (HP:0000855)2.33033416
87Enlarged epiphyses (HP:0010580)2.32822291
88Wormian bones (HP:0002645)2.32185963
89Congenital glaucoma (HP:0001087)2.31484360
90Skin nodule (HP:0200036)2.27837253
91Epidermoid cyst (HP:0200040)2.25892161
92Complement deficiency (HP:0004431)2.24905065
93Ectopia lentis (HP:0001083)2.24568707
94Abnormality of the 1st metacarpal (HP:0010009)2.24143109
95Adrenal overactivity (HP:0002717)2.19638523
96Abnormality of the nasal mucosa (HP:0000433)2.19101141
97Abnormality of chloride homeostasis (HP:0011422)2.19000840
98Hyperphosphatemia (HP:0002905)2.18139893
99Neuroendocrine neoplasm (HP:0100634)2.17348736
100Hemorrhage of the eye (HP:0011885)2.17189736
101Chronic bronchitis (HP:0004469)2.16437487
102Abnormal respiratory motile cilium physiology (HP:0012261)2.16043852
103Cerebral inclusion bodies (HP:0100314)2.10093552
104Hypokalemic alkalosis (HP:0001949)2.09935460
105Neurofibrillary tangles (HP:0002185)2.09797136
106Abdominal distention (HP:0003270)2.09778907
107Prominent metopic ridge (HP:0005487)2.08977158
108Hemiparesis (HP:0001269)2.08330634
109Systemic lupus erythematosus (HP:0002725)2.07590427
110Abnormality of complement system (HP:0005339)2.07503530
111Coxa vara (HP:0002812)2.07428438
112Exocrine pancreatic insufficiency (HP:0001738)2.07310378
113Failure to thrive in infancy (HP:0001531)2.06237184
114Abnormal platelet volume (HP:0011876)2.06123565
115Atonic seizures (HP:0010819)2.05828342
116Polycythemia (HP:0001901)2.03441351
117Hypothermia (HP:0002045)2.01267759
118Bell-shaped thorax (HP:0001591)1.98689800
119Metaphyseal dysplasia (HP:0100255)1.98473224
120Hypotension (HP:0002615)1.97582005
121Restlessness (HP:0000711)1.96439732
122Venous insufficiency (HP:0005293)1.95711462
123Difficulty running (HP:0009046)1.95295016
124Ovoid vertebral bodies (HP:0003300)1.93736130
125Infantile muscular hypotonia (HP:0008947)1.92801451
126Ileus (HP:0002595)1.90273850
127Epileptic encephalopathy (HP:0200134)1.89600428
128Abnormality of the metopic suture (HP:0005556)1.87219772
129Vacuolated lymphocytes (HP:0001922)1.86717044
130Accelerated skeletal maturation (HP:0005616)1.85753050
131Generalized tonic-clonic seizures (HP:0002069)1.85710596
132Atelectasis (HP:0100750)1.85409177
133Pigmentary retinal degeneration (HP:0001146)1.85284304
134Dilatation of the ascending aorta (HP:0005111)1.85228699
135Macroorchidism (HP:0000053)1.85192225
136Venous abnormality (HP:0002624)1.83817409
137Stridor (HP:0010307)1.83602630
138Diplopia (HP:0000651)1.83558059
139Abnormality of binocular vision (HP:0011514)1.83558059
140Protuberant abdomen (HP:0001538)1.82339515
141Postural tremor (HP:0002174)1.82192194
142Hypophosphatemia (HP:0002148)1.82090908
143Mildly elevated creatine phosphokinase (HP:0008180)1.81358621
144Genu recurvatum (HP:0002816)1.81172920
145Villous atrophy (HP:0011473)1.81035888
146Abnormality of small intestinal villus morphology (HP:0011472)1.81035888
147Depression (HP:0000716)1.78674632
148Neoplasm of the heart (HP:0100544)1.77464859
149Hypoventilation (HP:0002791)1.76500660
150Conical tooth (HP:0000698)1.75630569
151Osteoarthritis (HP:0002758)1.75629491
152Xanthomatosis (HP:0000991)1.75610714
153Abnormality of the proximal phalanges of the hand (HP:0009834)1.74872654
154Blue sclerae (HP:0000592)1.74748445
155Purpura (HP:0000979)1.74367065
156Bladder diverticulum (HP:0000015)1.74014668
157Megalencephaly (HP:0001355)1.73773663
158Hyperextensible skin (HP:0000974)1.73235007
159Type 1 muscle fiber predominance (HP:0003803)1.73028846
160Flared iliac wings (HP:0002869)1.72522397
161Cortical visual impairment (HP:0100704)1.72221041
162Torticollis (HP:0000473)1.72200600
163Aneurysm (HP:0002617)1.71242901
164Slender build (HP:0001533)1.71229277
165Severe short stature (HP:0003510)1.71216867
166Thoracolumbar scoliosis (HP:0002944)1.71205320
167Obstructive sleep apnea (HP:0002870)1.70413452
168Short 1st metacarpal (HP:0010034)1.70308134
169Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70308134
170Hip contracture (HP:0003273)1.69709312
171Hypoplasia of the fovea (HP:0007750)1.69490825
172Aplasia/Hypoplasia of the fovea (HP:0008060)1.69490825
173Bulbous nose (HP:0000414)1.69124563
174White forelock (HP:0002211)1.69054768
175Neonatal short-limb short stature (HP:0008921)1.68914563
176Hypoplasia of the odontoid process (HP:0003311)1.68556217
177Hyperphosphaturia (HP:0003109)1.68203969
178Hypocalcemia (HP:0002901)1.67992642
179Ventricular fibrillation (HP:0001663)1.67723920
180Spinal cord compression (HP:0002176)1.67002563
181Hyperaldosteronism (HP:0000859)1.65977443
182Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.65830558
183Symphalangism affecting the phalanges of the hand (HP:0009773)1.64853760
184Anxiety (HP:0000739)1.63617825
185Prolonged QT interval (HP:0001657)1.63591137
186Absence seizures (HP:0002121)1.62693571
187Dysautonomia (HP:0002459)1.62340914
188Menstrual irregularities (HP:0000858)1.61112415
189Back pain (HP:0003418)1.60291179

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.48364002
2PASK3.88963244
3TAOK33.74761273
4PRKD33.59842203
5EPHB23.58345713
6NTRK33.10518576
7IRAK33.05032300
8MAP3K23.00373236
9TGFBR22.78733985
10MYLK2.66688182
11HIPK22.51284959
12TIE12.50052608
13MAP3K12.46926397
14RIPK12.32184543
15MAPK152.14762396
16CAMKK22.13810679
17WNK42.13545930
18NTRK12.11210666
19FRK1.91217483
20LMTK21.89138170
21UHMK11.86130166
22LATS11.84139488
23PRKAA21.82105562
24TESK11.80372793
25MAP3K61.66432749
26ABL21.61630603
27CAMK11.59248014
28PRKCH1.52956775
29TRIB31.52401193
30MARK11.49553920
31ERN11.45822473
32CDC42BPA1.44108159
33PRKD21.42514468
34CAMKK11.40083469
35IRAK21.39533115
36LATS21.39404790
37NLK1.30636081
38SCYL21.30403909
39PDGFRA1.25527444
40MAP3K91.21286931
41IRAK11.17030228
42MAPK121.16445923
43GRK11.16060200
44KSR21.16006314
45RET1.15581208
46MINK11.12362924
47AKT31.12318967
48TNIK1.11653680
49ACVR1B1.10041940
50MAP2K21.09841480
51MAPK41.08190292
52RIPK41.03827551
53PAK31.03586665
54PTK21.03570448
55CAMK1G1.01720545
56PTK2B1.01315225
57MAP3K40.99249545
58KIT0.98082788
59GSK3A0.95149891
60MAPKAPK30.95010216
61BRAF0.94906905
62TRPM70.93154227
63PRKCE0.92929846
64EPHB10.91583846
65FGFR20.91204087
66GRK50.90392426
67CAMK2D0.89107729
68ROCK10.89027610
69WNK10.88414898
70STK380.83561871
71MAPK70.83470364
72PTK60.82996824
73SIK10.80054225
74CDK50.79937361
75DAPK30.78341479
76EPHA30.76613069
77RPS6KA20.76116688
78* ADRBK10.76067424
79PHKG20.72568227
80PHKG10.72568227
81SGK20.71851268
82NTRK20.69966795
83FLT30.69686491
84PNCK0.69404590
85MAP2K40.68411211
86DYRK1B0.68221877
87PAK60.68126496
88STK30.67870541
89PRKG10.67668743
90PDPK10.67122963
91TAOK10.67086049
92SIK20.66410497
93MET0.65932601
94ILK0.62623442
95PIK3CA0.62093176
96YES10.61931135
97CAMK2B0.61888701
98JAK20.59601458
99STK38L0.58548231
100GRK70.58170708
101DYRK20.58141531
102IRAK40.57931501
103CAMK2A0.57543799
104PRKD10.56251279
105MAPK130.56017578
106PRKCI0.54448116
107FER0.54428871
108MARK20.54224354
109ADRBK20.52932454
110ROCK20.52612975
111ALK0.52348001
112MAP2K10.52019615
113TYRO30.51795690
114PRKCZ0.51472000
115EPHA20.51143918
116MST1R0.51077244
117BMX0.50064718
118CAMK1D0.49721190
119PRKCG0.49348592
120CSNK1A10.49046066
121DAPK20.48410531
122STK110.47948250
123DYRK1A0.47490317
124PRKACG0.47132286
125PKN10.47074403
126ABL10.46745703
127PRKAA10.46447449
128EPHA40.46415079
129SGK2230.46400256
130SGK4940.46400256
131PINK10.43054578
132CASK0.42944526
133MAP2K70.42353069
134MAP3K70.42038862
135PRKG20.41091393
136PRKACA0.40215291
137PDGFRB0.39809759
138SGK10.36923026
139DMPK0.36504811
140RPS6KA30.34984377
141CDK90.34425846
142SGK30.34267480
143DDR20.34184044
144FES0.33699675
145BMPR1B0.33612296
146PRKCB0.32723302
147JAK10.32526119
148PDK10.32285714
149* PRKCA0.32148079

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.77196408
2Protein export_Homo sapiens_hsa030603.29413402
3Insulin secretion_Homo sapiens_hsa049113.21656764
4Sulfur metabolism_Homo sapiens_hsa009202.92764538
5PPAR signaling pathway_Homo sapiens_hsa033202.76553051
6Glycerolipid metabolism_Homo sapiens_hsa005612.66431425
7Type II diabetes mellitus_Homo sapiens_hsa049302.62084580
8Phenylalanine metabolism_Homo sapiens_hsa003602.51424335
9Histidine metabolism_Homo sapiens_hsa003402.40088677
10Tyrosine metabolism_Homo sapiens_hsa003502.32745378
11Type I diabetes mellitus_Homo sapiens_hsa049402.14965226
12beta-Alanine metabolism_Homo sapiens_hsa004102.13449925
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.07459072
14ECM-receptor interaction_Homo sapiens_hsa045122.00881401
15Cocaine addiction_Homo sapiens_hsa050301.97317953
16Fatty acid degradation_Homo sapiens_hsa000711.85602154
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79195659
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73601871
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.69639810
20Amphetamine addiction_Homo sapiens_hsa050311.68140713
21Vibrio cholerae infection_Homo sapiens_hsa051101.67011943
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66409071
23Taste transduction_Homo sapiens_hsa047421.62708596
24Pancreatic secretion_Homo sapiens_hsa049721.56935463
25Synaptic vesicle cycle_Homo sapiens_hsa047211.55047742
26GABAergic synapse_Homo sapiens_hsa047271.54765358
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53580102
28Fatty acid biosynthesis_Homo sapiens_hsa000611.51115519
29Chemical carcinogenesis_Homo sapiens_hsa052041.48722340
30Fatty acid elongation_Homo sapiens_hsa000621.47637861
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46922615
32Long-term potentiation_Homo sapiens_hsa047201.46436044
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41869933
34Circadian entrainment_Homo sapiens_hsa047131.39463606
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34685291
36Dopaminergic synapse_Homo sapiens_hsa047281.34252325
37Cholinergic synapse_Homo sapiens_hsa047251.33353936
38Tryptophan metabolism_Homo sapiens_hsa003801.32756998
39Retinol metabolism_Homo sapiens_hsa008301.31052957
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30763960
41Morphine addiction_Homo sapiens_hsa050321.30055788
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.29281093
43AMPK signaling pathway_Homo sapiens_hsa041521.27358602
44Ovarian steroidogenesis_Homo sapiens_hsa049131.24548432
45Serotonergic synapse_Homo sapiens_hsa047261.20628528
46Glutamatergic synapse_Homo sapiens_hsa047241.19437197
47Renin secretion_Homo sapiens_hsa049241.19002889
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18243835
49Nicotine addiction_Homo sapiens_hsa050331.17134909
50Gastric acid secretion_Homo sapiens_hsa049711.13883028
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10597714
52Thyroid hormone synthesis_Homo sapiens_hsa049181.08959426
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07422235
54Propanoate metabolism_Homo sapiens_hsa006401.06188017
55Fatty acid metabolism_Homo sapiens_hsa012121.03741008
56Pyruvate metabolism_Homo sapiens_hsa006201.03460843
57Lysosome_Homo sapiens_hsa041421.03286504
58Estrogen signaling pathway_Homo sapiens_hsa049151.03202496
59Salivary secretion_Homo sapiens_hsa049701.03179980
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02627987
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02072770
62Focal adhesion_Homo sapiens_hsa045100.99988462
63Collecting duct acid secretion_Homo sapiens_hsa049660.99409491
64Glutathione metabolism_Homo sapiens_hsa004800.97872065
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.97436940
66Dorso-ventral axis formation_Homo sapiens_hsa043200.96388289
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94870006
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91666986
69Prolactin signaling pathway_Homo sapiens_hsa049170.91416378
70Prion diseases_Homo sapiens_hsa050200.89715443
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.88907816
72N-Glycan biosynthesis_Homo sapiens_hsa005100.88533323
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.87820534
74Glucagon signaling pathway_Homo sapiens_hsa049220.85910989
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.85906870
76Renin-angiotensin system_Homo sapiens_hsa046140.84522229
77Long-term depression_Homo sapiens_hsa047300.84448082
78Olfactory transduction_Homo sapiens_hsa047400.84192450
79Gap junction_Homo sapiens_hsa045400.81927432
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.81483928
81Insulin resistance_Homo sapiens_hsa049310.80995643
82Platelet activation_Homo sapiens_hsa046110.79771158
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.78555159
84cAMP signaling pathway_Homo sapiens_hsa040240.78266546
85* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77871335
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76257587
87Circadian rhythm_Homo sapiens_hsa047100.75070284
88GnRH signaling pathway_Homo sapiens_hsa049120.74438545
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72785528
90Melanogenesis_Homo sapiens_hsa049160.71384785
91Axon guidance_Homo sapiens_hsa043600.70997853
92Arachidonic acid metabolism_Homo sapiens_hsa005900.70081401
93Other glycan degradation_Homo sapiens_hsa005110.66414954
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66048208
95Calcium signaling pathway_Homo sapiens_hsa040200.62971700
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62832167
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59863865
98Insulin signaling pathway_Homo sapiens_hsa049100.58872339
99Oxytocin signaling pathway_Homo sapiens_hsa049210.57734133
100Nitrogen metabolism_Homo sapiens_hsa009100.57629308
101Arginine and proline metabolism_Homo sapiens_hsa003300.54278560
102Protein digestion and absorption_Homo sapiens_hsa049740.53903828
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52512329
104Butanoate metabolism_Homo sapiens_hsa006500.52364969
105Tight junction_Homo sapiens_hsa045300.51972767
106Rap1 signaling pathway_Homo sapiens_hsa040150.51545785
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.50689123
108Vitamin B6 metabolism_Homo sapiens_hsa007500.50517703
109Glioma_Homo sapiens_hsa052140.48557277
110TGF-beta signaling pathway_Homo sapiens_hsa043500.47511325
111* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47414178
112Sphingolipid metabolism_Homo sapiens_hsa006000.47391040
113Alzheimers disease_Homo sapiens_hsa050100.47244612
114Amoebiasis_Homo sapiens_hsa051460.47121926
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46624793
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46583360
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45445091
118Galactose metabolism_Homo sapiens_hsa000520.44633242
119Bile secretion_Homo sapiens_hsa049760.44585515
120Vitamin digestion and absorption_Homo sapiens_hsa049770.44352917
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43460151
122Melanoma_Homo sapiens_hsa052180.43208011
123Peroxisome_Homo sapiens_hsa041460.43171401
124mTOR signaling pathway_Homo sapiens_hsa041500.43153480
125Mineral absorption_Homo sapiens_hsa049780.43005507
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42897823
127Cardiac muscle contraction_Homo sapiens_hsa042600.42854461
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.42655208
129Alcoholism_Homo sapiens_hsa050340.42118183
130Adherens junction_Homo sapiens_hsa045200.42111345
131ABC transporters_Homo sapiens_hsa020100.41539905
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39925794
133Bladder cancer_Homo sapiens_hsa052190.39849568
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39619629
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39058856
136Dilated cardiomyopathy_Homo sapiens_hsa054140.38653614
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38548819
138Inositol phosphate metabolism_Homo sapiens_hsa005620.34764193
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34573246
140Hedgehog signaling pathway_Homo sapiens_hsa043400.34457940
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31746167
142MAPK signaling pathway_Homo sapiens_hsa040100.31074971
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30335039
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30092796
145Fat digestion and absorption_Homo sapiens_hsa049750.29863741
146Endometrial cancer_Homo sapiens_hsa052130.29832123
147Renal cell carcinoma_Homo sapiens_hsa052110.28970376
148Regulation of autophagy_Homo sapiens_hsa041400.28457228
149Linoleic acid metabolism_Homo sapiens_hsa005910.28400935
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28270925

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