ADRM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.04577193
2protein maturation by protein folding (GO:0022417)5.02814072
3formation of translation preinitiation complex (GO:0001731)4.83708139
4negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.72754447
5COPI coating of Golgi vesicle (GO:0048205)4.69703183
6Golgi transport vesicle coating (GO:0048200)4.69703183
7folic acid metabolic process (GO:0046655)4.57406251
8nucleobase biosynthetic process (GO:0046112)4.52477321
9purine nucleobase biosynthetic process (GO:0009113)4.51693127
10ribosome assembly (GO:0042255)4.37278702
11ribosome biogenesis (GO:0042254)4.00791586
12nucleobase-containing small molecule interconversion (GO:0015949)3.98919492
13mitotic nuclear envelope reassembly (GO:0007084)3.88748736
14nuclear envelope reassembly (GO:0031468)3.88748736
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.83006240
16folic acid-containing compound biosynthetic process (GO:0009396)3.80856102
17pentose-phosphate shunt (GO:0006098)3.71592008
18GDP-mannose metabolic process (GO:0019673)3.68946680
19proline biosynthetic process (GO:0006561)3.68193143
20DNA strand elongation involved in DNA replication (GO:0006271)3.66768372
21DNA replication checkpoint (GO:0000076)3.65958056
22mitotic metaphase plate congression (GO:0007080)3.62739511
23glycine metabolic process (GO:0006544)3.61514756
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58630273
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.55547903
26establishment of integrated proviral latency (GO:0075713)3.52518673
27establishment of viral latency (GO:0019043)3.51624471
28maturation of SSU-rRNA (GO:0030490)3.50571887
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50434861
30DNA replication initiation (GO:0006270)3.49891076
31regulation of translational termination (GO:0006449)3.49842606
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.47587977
33peptidyl-arginine omega-N-methylation (GO:0035247)3.46596801
34DNA strand elongation (GO:0022616)3.45730852
35protein retention in ER lumen (GO:0006621)3.42819848
36protein localization to kinetochore (GO:0034501)3.40356042
37mitotic nuclear envelope disassembly (GO:0007077)3.40015249
38regulation of mammary gland epithelial cell proliferation (GO:0033599)3.39824825
39maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38282472
40NADPH regeneration (GO:0006740)3.37896549
41ribonucleoprotein complex biogenesis (GO:0022613)3.33001907
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31958823
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.26126614
44negative regulation of ligase activity (GO:0051352)3.26126614
45glucose catabolic process (GO:0006007)3.22626493
46IMP biosynthetic process (GO:0006188)3.22138416
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19230817
48rRNA modification (GO:0000154)3.18520521
49L-methionine salvage (GO:0071267)3.18300045
50L-methionine biosynthetic process (GO:0071265)3.18300045
51amino acid salvage (GO:0043102)3.18300045
52telomere maintenance via semi-conservative replication (GO:0032201)3.17583762
53folic acid transport (GO:0015884)3.15565990
54negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.14782515
55membrane disassembly (GO:0030397)3.12769127
56nuclear envelope disassembly (GO:0051081)3.12769127
57spliceosomal snRNP assembly (GO:0000387)3.10275584
58ribosomal large subunit biogenesis (GO:0042273)3.07788801
59mitotic chromosome condensation (GO:0007076)3.07271287
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07149165
61signal transduction involved in DNA damage checkpoint (GO:0072422)3.06890553
62signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06890553
63ribosomal small subunit biogenesis (GO:0042274)3.05726463
64pentose metabolic process (GO:0019321)3.05378895
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05295253
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05295253
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05295253
68DNA unwinding involved in DNA replication (GO:0006268)3.05230177
69regulation of cellular amino acid metabolic process (GO:0006521)3.05091372
70rRNA processing (GO:0006364)3.04053321
71retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.03782668
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02670853
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02670853
74pyrimidine-containing compound salvage (GO:0008655)3.01850714
75pyrimidine nucleoside salvage (GO:0043097)3.01850714
76histone arginine methylation (GO:0034969)3.01752557
77spliceosomal tri-snRNP complex assembly (GO:0000244)3.01391191
78signal transduction involved in cell cycle checkpoint (GO:0072395)3.00967031
79positive regulation of ligase activity (GO:0051351)3.00864282
80pseudouridine synthesis (GO:0001522)3.00024153
81regulation of mitochondrial translation (GO:0070129)2.99818299
82methionine biosynthetic process (GO:0009086)2.98303498
83maturation of 5.8S rRNA (GO:0000460)2.93348733
84rRNA metabolic process (GO:0016072)2.92956121
85protein localization to chromosome, centromeric region (GO:0071459)2.92268419
86pinocytosis (GO:0006907)2.92035090
87serine family amino acid biosynthetic process (GO:0009070)2.91594256
88* proteasome assembly (GO:0043248)2.90484688
89translational initiation (GO:0006413)2.89201709
90DNA replication-dependent nucleosome assembly (GO:0006335)2.88852702
91DNA replication-dependent nucleosome organization (GO:0034723)2.88852702
92NADH metabolic process (GO:0006734)2.88541676
93L-serine metabolic process (GO:0006563)2.88367083
94regulation of spindle organization (GO:0090224)2.88312163
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88149710
96sulfur amino acid biosynthetic process (GO:0000097)2.88146577
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.86664077
98termination of RNA polymerase III transcription (GO:0006386)2.86664077
99folic acid-containing compound metabolic process (GO:0006760)2.86651991
100regulation of translation in response to stress (GO:0043555)2.85362322
101aspartate family amino acid biosynthetic process (GO:0009067)2.85272384
102regulation of ubiquitin-protein transferase activity (GO:0051438)2.84049495
103protein complex localization (GO:0031503)2.83938185
104nucleoside salvage (GO:0043174)2.81803014
105G1/S transition of mitotic cell cycle (GO:0000082)2.81664402
106cell cycle G1/S phase transition (GO:0044843)2.81664402
107metaphase plate congression (GO:0051310)2.78193764
108methionine metabolic process (GO:0006555)2.77883356
109mitotic G1 DNA damage checkpoint (GO:0031571)2.76391766
110negative regulation of translational initiation (GO:0045947)2.75825267
111telomere maintenance via recombination (GO:0000722)2.74532231
112nucleotide salvage (GO:0043173)2.73787972
113regulation of translational fidelity (GO:0006450)2.73353272
114IMP metabolic process (GO:0046040)2.73265392
115negative regulation of cell size (GO:0045792)2.72341198
116mitochondrial fusion (GO:0008053)2.71294857
117regulation of ligase activity (GO:0051340)2.70114764
118guanosine-containing compound biosynthetic process (GO:1901070)2.70031415
119pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.69202670
120barbed-end actin filament capping (GO:0051016)2.68891593
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.68769120
122positive regulation of cell cycle arrest (GO:0071158)2.68562582
123telomere maintenance via telomere lengthening (GO:0010833)2.65368982
124positive regulation of Cdc42 GTPase activity (GO:0043089)2.64485169
125positive regulation of chromosome segregation (GO:0051984)2.64032424
126endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.63739487
127serine family amino acid metabolic process (GO:0009069)2.63687495
128protein localization to endosome (GO:0036010)2.63364330
129peptidyl-arginine methylation (GO:0018216)2.63261889
130peptidyl-arginine N-methylation (GO:0035246)2.63261889
131nuclear envelope organization (GO:0006998)2.62109439
132tRNA methylation (GO:0030488)2.60799422
133tetrahydrofolate metabolic process (GO:0046653)2.60070532
134regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.59542957
135ribosomal small subunit assembly (GO:0000028)2.59145544
136regulation of posttranscriptional gene silencing (GO:0060147)2.59054491
137regulation of gene silencing by miRNA (GO:0060964)2.59054491
138regulation of gene silencing by RNA (GO:0060966)2.59054491
139regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.58245998
140positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.58220391
141mitotic sister chromatid segregation (GO:0000070)2.57091378
142NIK/NF-kappaB signaling (GO:0038061)2.56628481
143monosaccharide biosynthetic process (GO:0046364)2.56604469
144cellular protein complex localization (GO:0034629)2.56195784
145pteridine-containing compound biosynthetic process (GO:0042559)2.56168341
146cullin deneddylation (GO:0010388)2.54598778
147protein deneddylation (GO:0000338)2.54486266
148negative regulation of chromosome segregation (GO:0051985)2.53631763
149rRNA transcription (GO:0009303)2.52767030
150antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.52657360
151protein targeting to mitochondrion (GO:0006626)2.52032508
152transcription from mitochondrial promoter (GO:0006390)2.51921030
153pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.50554987
154positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.49371294
155pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.48171838
156regulation of cellular amine metabolic process (GO:0033238)2.47742019
1572-deoxyribonucleotide biosynthetic process (GO:0009265)2.45567042
158deoxyribose phosphate biosynthetic process (GO:0046385)2.45567042
159heterochromatin organization (GO:0070828)2.45491949
160de novo protein folding (GO:0006458)2.42735012
161gluconeogenesis (GO:0006094)2.42141321
162deoxyribonucleotide biosynthetic process (GO:0009263)2.41930116
163apoptotic process involved in morphogenesis (GO:0060561)2.41889100
164de novo posttranslational protein folding (GO:0051084)2.41614317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.04379676
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82177672
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.68336719
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.82113104
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78814927
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.72120899
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66646210
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64382798
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49299593
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46093669
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45811341
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.42899998
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.40979017
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34124553
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27497073
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13984498
17XRN2_22483619_ChIP-Seq_HELA_Human2.11919184
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06316389
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93763606
20* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89204748
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88269654
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85475520
23NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84660387
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84042914
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.83942588
26* GABP_19822575_ChIP-Seq_HepG2_Human1.83444686
27DCP1A_22483619_ChIP-Seq_HELA_Human1.81363609
28VDR_23849224_ChIP-Seq_CD4+_Human1.79363202
29LXR_22292898_ChIP-Seq_THP-1_Human1.77972105
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71988870
31MYC_22102868_ChIP-Seq_BL_Human1.70115600
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68476683
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.67188640
34AR_21909140_ChIP-Seq_LNCAP_Human1.67138289
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66361556
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65966388
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64781919
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63316123
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62518683
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60962166
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.60756973
42FOXP3_21729870_ChIP-Seq_TREG_Human1.55871094
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51977207
44CIITA_25753668_ChIP-Seq_RAJI_Human1.47994616
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47988728
46KDM5A_27292631_Chip-Seq_BREAST_Human1.47981921
47* TET1_21451524_ChIP-Seq_MESCs_Mouse1.47948263
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46259320
49ZNF263_19887448_ChIP-Seq_K562_Human1.45931053
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44823289
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42472039
52TTF2_22483619_ChIP-Seq_HELA_Human1.41651150
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40538980
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40371156
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39761336
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39018940
57* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38559684
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37785966
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36670511
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.34729043
61* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31844477
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31463476
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31291775
64* E2F1_21310950_ChIP-Seq_MCF-7_Human1.30304755
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25367963
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24173567
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.23983190
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23958943
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23759125
70P68_20966046_ChIP-Seq_HELA_Human1.23168161
71* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22987356
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22794439
73TFEB_21752829_ChIP-Seq_HELA_Human1.22401122
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21510081
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21230532
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17287133
77VDR_21846776_ChIP-Seq_THP-1_Human1.14405264
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.11558310
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10388288
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09815368
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09544746
82OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09079297
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09076731
84* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08887397
85* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08153851
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07653850
87* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06789157
88* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06610860
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06403763
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06198922
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05370716
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04147515
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03861774
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.03685598
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03560693
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02906730
97* ATF3_27146783_Chip-Seq_COLON_Human1.02568810
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02180480
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01896911
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.00759348
101TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00280418
102SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99978728
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99793532
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99651505
105SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99133716
106CLOCK_20551151_ChIP-Seq_293T_Human0.98623325
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.97959963
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97405259
109BCOR_27268052_Chip-Seq_Bcells_Human0.97018155
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96991070
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96893894
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96797032
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96447241
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96434529
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96119368
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95979216
117* ELK3_25401928_ChIP-Seq_HUVEC_Human0.95672557
118* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94890790
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94329078
120* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92014205
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91862716
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91085112
123KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90787917
124KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90787917
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90787917
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90335539
127YY1_22570637_ChIP-Seq_MALME-3M_Human0.89509020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.88132249
2MP0003111_abnormal_nucleus_morphology3.86302327
3MP0004957_abnormal_blastocyst_morpholog3.77153475
4MP0002877_abnormal_melanocyte_morpholog3.32335970
5MP0009840_abnormal_foam_cell3.18504243
6MP0003806_abnormal_nucleotide_metabolis3.11067947
7MP0003077_abnormal_cell_cycle3.09215048
8MP0010094_abnormal_chromosome_stability2.96805007
9MP0001730_embryonic_growth_arrest2.32552622
10MP0010352_gastrointestinal_tract_polyps2.31936947
11MP0004233_abnormal_muscle_weight2.21948216
12MP0008932_abnormal_embryonic_tissue2.13616958
13MP0008058_abnormal_DNA_repair2.10377674
14MP0003705_abnormal_hypodermis_morpholog2.09626109
15MP0008007_abnormal_cellular_replicative2.02748362
16MP0003718_maternal_effect1.99885282
17MP0002796_impaired_skin_barrier1.99603285
18MP0008057_abnormal_DNA_replication1.92922013
19MP0002139_abnormal_hepatobiliary_system1.90177832
20MP0010234_abnormal_vibrissa_follicle1.83803613
21MP0004185_abnormal_adipocyte_glucose1.83446999
22MP0003453_abnormal_keratinocyte_physiol1.83288173
23MP0000350_abnormal_cell_proliferation1.80627373
24MP0003786_premature_aging1.73776758
25MP0003186_abnormal_redox_activity1.63572035
26MP0001672_abnormal_embryogenesis/_devel1.62273075
27MP0005380_embryogenesis_phenotype1.62273075
28MP0001697_abnormal_embryo_size1.55437000
29MP0004858_abnormal_nervous_system1.54856174
30MP0002080_prenatal_lethality1.53314315
31MP0005360_urolithiasis1.52802322
32MP0010307_abnormal_tumor_latency1.51922588
33MP0003984_embryonic_growth_retardation1.49166584
34MP0002088_abnormal_embryonic_growth/wei1.47373989
35MP0003123_paternal_imprinting1.47007392
36MP0000678_abnormal_parathyroid_gland1.45360807
37MP0009333_abnormal_splenocyte_physiolog1.43320219
38MP0005257_abnormal_intraocular_pressure1.41709942
39MP0005365_abnormal_bile_salt1.38980209
40MP0005397_hematopoietic_system_phenotyp1.37607709
41MP0001545_abnormal_hematopoietic_system1.37607709
42MP0008438_abnormal_cutaneous_collagen1.33252308
43MP0005085_abnormal_gallbladder_physiolo1.32825313
44MP0002060_abnormal_skin_morphology1.32626675
45MP0002396_abnormal_hematopoietic_system1.32384209
46MP0000750_abnormal_muscle_regeneration1.31909643
47MP0000751_myopathy1.31802116
48MP0010030_abnormal_orbit_morphology1.30560832
49MP0002086_abnormal_extraembryonic_tissu1.29929150
50MP0002653_abnormal_ependyma_morphology1.28918738
51MP0000747_muscle_weakness1.28753542
52MP0000490_abnormal_crypts_of1.28651297
53MP0005670_abnormal_white_adipose1.27220556
54MP0000343_altered_response_to1.26941040
55MP0000358_abnormal_cell_content/1.26148336
56MP0002085_abnormal_embryonic_tissue1.23739015
57MP0000313_abnormal_cell_death1.22557757
58MP0002019_abnormal_tumor_incidence1.21635050
59MP0000537_abnormal_urethra_morphology1.20898716
60MP0004197_abnormal_fetal_growth/weight/1.19637039
61MP0000749_muscle_degeneration1.19594355
62MP0002269_muscular_atrophy1.19115843
63MP0001216_abnormal_epidermal_layer1.16235233
64MP0004510_myositis1.15951857
65MP0003221_abnormal_cardiomyocyte_apopto1.15430093
66MP0002084_abnormal_developmental_patter1.15311815
67MP0005332_abnormal_amino_acid1.13392774
68MP0006036_abnormal_mitochondrial_physio1.13371198
69MP0005023_abnormal_wound_healing1.11674448
70MP0005451_abnormal_body_composition1.11440826
71MP0003191_abnormal_cellular_cholesterol1.11264964
72MP0003656_abnormal_erythrocyte_physiolo1.11124930
73MP0003566_abnormal_cell_adhesion1.07504211
74MP0005319_abnormal_enzyme/_coenzyme1.07421850
75MP0004272_abnormal_basement_membrane1.05925651
76MP0009053_abnormal_anal_canal1.05002527
77MP0003172_abnormal_lysosome_physiology1.04814521
78MP0003119_abnormal_digestive_system1.03628018
79MP0000609_abnormal_liver_physiology1.03142261
80MP0003646_muscle_fatigue1.03016011
81MP0003436_decreased_susceptibility_to1.02977760
82MP0003567_abnormal_fetal_cardiomyocyte1.02139014
83MP0000003_abnormal_adipose_tissue1.01597045
84MP0000598_abnormal_liver_morphology1.01411567
85MP0008260_abnormal_autophagy1.01389083
86MP0009278_abnormal_bone_marrow1.00656217
87MP0000733_abnormal_muscle_development1.00513348
88MP0006035_abnormal_mitochondrial_morpho1.00355493
89MP0005623_abnormal_meninges_morphology0.99810792
90MP0004019_abnormal_vitamin_homeostasis0.99418978
91MP0000759_abnormal_skeletal_muscle0.98930814
92MP0003315_abnormal_perineum_morphology0.98663535
93MP0005165_increased_susceptibility_to0.97911580
94MP0000858_altered_metastatic_potential0.96056791
95MP0003075_altered_response_to0.94346861
96MP0001243_abnormal_dermal_layer0.93927599
97MP0004947_skin_inflammation0.93718234
98MP0001849_ear_inflammation0.93207381
99MP0005666_abnormal_adipose_tissue0.92766696
100MP0002132_abnormal_respiratory_system0.92274480
101MP0001881_abnormal_mammary_gland0.90029876
102MP0005083_abnormal_biliary_tract0.88915723
103MP0000467_abnormal_esophagus_morphology0.88606714
104MP0005375_adipose_tissue_phenotype0.86944902
105MP0005395_other_phenotype0.86470321
106MP0005076_abnormal_cell_differentiation0.85260094
107MP0003941_abnormal_skin_development0.84335875
108MP0002148_abnormal_hypersensitivity_rea0.83913746
109MP0002254_reproductive_system_inflammat0.83305733
110MP0005058_abnormal_lysosome_morphology0.82782861
111MP0009931_abnormal_skin_appearance0.81834963
112MP0005377_hearing/vestibular/ear_phenot0.81553368
113MP0003878_abnormal_ear_physiology0.81553368
114MP0009643_abnormal_urine_homeostasis0.81375506
115MP0010329_abnormal_lipoprotein_level0.81115295
116MP0003448_altered_tumor_morphology0.80425356
117MP0001764_abnormal_homeostasis0.80341413
118MP0002089_abnormal_postnatal_growth/wei0.79193720
119MP0005464_abnormal_platelet_physiology0.78296174
120MP0010771_integument_phenotype0.77322914
121MP0001727_abnormal_embryo_implantation0.75441991
122MP0001756_abnormal_urination0.75396860
123MP0005384_cellular_phenotype0.75236567
124MP0008877_abnormal_DNA_methylation0.75208772
125* MP0002722_abnormal_immune_system0.75047480
126MP0000689_abnormal_spleen_morphology0.74910844
127MP0004087_abnormal_muscle_fiber0.74833418
128MP0005330_cardiomyopathy0.74712298
129MP0003303_peritoneal_inflammation0.74322708
130MP0005621_abnormal_cell_physiology0.74054497
131MP0002332_abnormal_exercise_endurance0.72567890
132MP0005266_abnormal_metabolism0.72553644
133MP0002210_abnormal_sex_determination0.71389624
134MP0005501_abnormal_skin_physiology0.70428672
135MP0001853_heart_inflammation0.69543469
136MP0004084_abnormal_cardiac_muscle0.69509597
137* MP0001145_abnormal_male_reproductive0.69372920
138MP0002111_abnormal_tail_morphology0.69071992
139MP0003763_abnormal_thymus_physiology0.67653376
140* MP0009672_abnormal_birth_weight0.66630679
141MP0000477_abnormal_intestine_morphology0.63868410
142MP0001661_extended_life_span0.62819747
143MP0004808_abnormal_hematopoietic_stem0.61292227
144MP0001915_intracranial_hemorrhage0.60978301

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)4.46180730
2Multiple enchondromatosis (HP:0005701)4.17277987
3Birth length less than 3rd percentile (HP:0003561)4.00847649
4Carpal bone hypoplasia (HP:0001498)3.58341824
5Cerebral hypomyelination (HP:0006808)3.47740667
6Degeneration of anterior horn cells (HP:0002398)3.47244372
7Abnormality of the anterior horn cell (HP:0006802)3.47244372
8Vertebral compression fractures (HP:0002953)3.39419124
9Distal lower limb muscle weakness (HP:0009053)3.39125837
10Achilles tendon contracture (HP:0001771)3.35605880
11Ragged-red muscle fibers (HP:0003200)3.33639430
12Oral leukoplakia (HP:0002745)3.30073898
13Rough bone trabeculation (HP:0100670)3.26642106
14Distal lower limb amyotrophy (HP:0008944)3.24390431
15Cholecystitis (HP:0001082)3.24201366
16Abnormal gallbladder physiology (HP:0012438)3.24201366
17Hyperglycinemia (HP:0002154)3.23673372
18Trismus (HP:0000211)3.21282088
19Hyperglycinuria (HP:0003108)3.17595323
20Premature ovarian failure (HP:0008209)3.11268052
21Abnormality of the Achilles tendon (HP:0005109)3.00059848
22Abnormality of glycolipid metabolism (HP:0010969)2.92066600
23Abnormality of liposaccharide metabolism (HP:0010968)2.92066600
24Abnormality of glycosphingolipid metabolism (HP:0004343)2.92066600
25Patellar aplasia (HP:0006443)2.91820159
26Aplasia/Hypoplasia of the patella (HP:0006498)2.87790203
27Progressive muscle weakness (HP:0003323)2.80845014
28Premature rupture of membranes (HP:0001788)2.77633274
29Selective tooth agenesis (HP:0001592)2.75948445
30Secondary amenorrhea (HP:0000869)2.71718145
31Abnormality of pyrimidine metabolism (HP:0004353)2.70456156
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.67469301
33Distal upper limb amyotrophy (HP:0007149)2.63055465
34Upper limb amyotrophy (HP:0009129)2.63055465
35Nausea (HP:0002018)2.62056723
36Increased connective tissue (HP:0009025)2.61431804
37Abnormality of serine family amino acid metabolism (HP:0010894)2.60841883
38Abnormality of glycine metabolism (HP:0010895)2.60841883
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.59079239
40Hypokinesia (HP:0002375)2.56211628
41Hyperacusis (HP:0010780)2.54184988
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51242657
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50857440
44Microretrognathia (HP:0000308)2.49068194
45Abnormality of cells of the erythroid lineage (HP:0012130)2.48410795
46Microvesicular hepatic steatosis (HP:0001414)2.47876846
47Reduced subcutaneous adipose tissue (HP:0003758)2.46719728
48Abnormal cartilage morphology (HP:0002763)2.44710859
49Impulsivity (HP:0100710)2.42911345
50Megaloblastic anemia (HP:0001889)2.40468548
51Axonal loss (HP:0003447)2.40003511
52Abnormal number of erythroid precursors (HP:0012131)2.39575996
53Atrophy/Degeneration involving motor neurons (HP:0007373)2.38050350
54Personality changes (HP:0000751)2.37664324
55Hypobetalipoproteinemia (HP:0003563)2.37650450
56Short nail (HP:0001799)2.36578218
57Generalized amyotrophy (HP:0003700)2.35315534
58Abnormality of glycolysis (HP:0004366)2.35264594
59Gout (HP:0001997)2.34951609
60Myopathic facies (HP:0002058)2.34463629
61Abnormality of serum amino acid levels (HP:0003112)2.32776218
62Abnormal trabecular bone morphology (HP:0100671)2.30252771
63Ependymoma (HP:0002888)2.27714754
64Difficulty climbing stairs (HP:0003551)2.26957299
65Hyperammonemia (HP:0001987)2.21086522
66Abnormal neuron morphology (HP:0012757)2.19454297
67Abnormality of the motor neurons (HP:0002450)2.19454297
68Rhabdomyolysis (HP:0003201)2.14895795
69Fasciculations (HP:0002380)2.14485242
70Abnormality of the umbilical cord (HP:0010881)2.12873249
71Broad distal phalanx of finger (HP:0009836)2.12098141
72Absent thumb (HP:0009777)2.10266663
73Lower limb amyotrophy (HP:0007210)2.10168711
74Reticulocytopenia (HP:0001896)2.10096386
75Neoplasm of the pancreas (HP:0002894)2.09138211
76Prolonged neonatal jaundice (HP:0006579)2.07087591
77Ureteral duplication (HP:0000073)2.06964000
78Macrocytic anemia (HP:0001972)2.05962559
79Death in infancy (HP:0001522)2.05657235
80Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02082514
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02082514
82Absent radius (HP:0003974)2.01967299
83Hypertensive crisis (HP:0100735)2.01836174
84Aplasia/Hypoplasia involving the musculature (HP:0001460)2.01739251
85Pustule (HP:0200039)2.01565043
86Ulnar bowing (HP:0003031)2.01545295
87Aplasia/hypoplasia of the humerus (HP:0006507)1.99956255
88Stridor (HP:0010307)1.99595542
89Increased cerebral lipofuscin (HP:0011813)1.99594072
90Breech presentation (HP:0001623)1.98143707
91Abnormality of reticulocytes (HP:0004312)1.97158769
92Muscle fibrillation (HP:0010546)1.96327663
93Nuclear cataract (HP:0100018)1.95965367
94Elbow flexion contracture (HP:0002987)1.95610465
95Hepatosplenomegaly (HP:0001433)1.95204713
96Abnormal mitochondria in muscle tissue (HP:0008316)1.93781785
97Sparse eyelashes (HP:0000653)1.93659197
98Increased intramyocellular lipid droplets (HP:0012240)1.92611774
99Increased serum pyruvate (HP:0003542)1.92464224
100Spinal muscular atrophy (HP:0007269)1.90968775
101Reticulocytosis (HP:0001923)1.89881360
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89583153
103Dicarboxylic aciduria (HP:0003215)1.89583153
104Type I transferrin isoform profile (HP:0003642)1.88931219
105Increased muscle lipid content (HP:0009058)1.88674783
106Tongue fasciculations (HP:0001308)1.87773421
107Long palpebral fissure (HP:0000637)1.87640732
108Hand muscle atrophy (HP:0009130)1.87088043
109Xanthomatosis (HP:0000991)1.85236243
110Poor head control (HP:0002421)1.84384814
111J-shaped sella turcica (HP:0002680)1.84208322
112CNS demyelination (HP:0007305)1.83799999
113Areflexia of lower limbs (HP:0002522)1.83729130
114Upper limb muscle weakness (HP:0003484)1.83667155
115Aplasia involving forearm bones (HP:0009822)1.83652136
116Absent forearm bone (HP:0003953)1.83652136
117Diaphragmatic weakness (HP:0009113)1.83152521
118Bulbar palsy (HP:0001283)1.83078859
119Spinal rigidity (HP:0003306)1.81566029
120Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81472120
121Abnormality of sulfur amino acid metabolism (HP:0004339)1.81136291
122Abnormal umbilical cord blood vessels (HP:0011403)1.81024953
123Single umbilical artery (HP:0001195)1.81024953
124Abnormality of the fetal cardiovascular system (HP:0010948)1.81024953
125Polycythemia (HP:0001901)1.80692236
126Entropion (HP:0000621)1.79789079
127Vacuolated lymphocytes (HP:0001922)1.79730891
128Back pain (HP:0003418)1.79606906
129Abnormality of fatty-acid metabolism (HP:0004359)1.79181220
130Increased neuronal autofluorescent lipopigment (HP:0002074)1.78502614
131Progressive neurologic deterioration (HP:0002344)1.77822270
132CNS hypomyelination (HP:0003429)1.77015295
133Cholelithiasis (HP:0001081)1.76783323
134Premature graying of hair (HP:0002216)1.75699057
135Micronodular cirrhosis (HP:0001413)1.75164391
136Lethargy (HP:0001254)1.75015419
137Reduced antithrombin III activity (HP:0001976)1.74952555
138Petechiae (HP:0000967)1.74895442
139Dysostosis multiplex (HP:0000943)1.74864635
140Spastic diplegia (HP:0001264)1.74307427
141Loss of speech (HP:0002371)1.74298386
142Upper motor neuron abnormality (HP:0002127)1.74138092
143Cellular immunodeficiency (HP:0005374)1.73681034
144Testicular atrophy (HP:0000029)1.73246869
145Deviation of the thumb (HP:0009603)1.72795874
146Spastic paraparesis (HP:0002313)1.72185547
147Osteolytic defects of the hand bones (HP:0009699)1.71815756
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.71815756
149Increased serum ferritin (HP:0003281)1.71248910
150Abnormality of nucleobase metabolism (HP:0010932)1.71189918
151Proximal placement of thumb (HP:0009623)1.69718768
152Limb-girdle muscle atrophy (HP:0003797)1.69238271
153Abnormality of the tricuspid valve (HP:0001702)1.69157292
154Adenoma sebaceum (HP:0009720)1.68523935
155Angiofibromas (HP:0010615)1.68523935
156Hypolipoproteinemia (HP:0010981)1.68226806
157Squamous cell carcinoma (HP:0002860)1.66459098
158Nonimmune hydrops fetalis (HP:0001790)1.66390379
159Colon cancer (HP:0003003)1.65704608
160Broad face (HP:0000283)1.65247870
161Exercise intolerance (HP:0003546)1.65239061
162Insomnia (HP:0100785)1.64813337
163Slender long bone (HP:0003100)1.64245656
164Progressive external ophthalmoplegia (HP:0000590)1.63845860
165Myocardial infarction (HP:0001658)1.63016345
166Mildly elevated creatine phosphokinase (HP:0008180)1.62295029
167Pelvic girdle muscle weakness (HP:0003749)1.62096363
168Opisthotonus (HP:0002179)1.61893383
169Horseshoe kidney (HP:0000085)1.61631128
170Muscle fiber splitting (HP:0003555)1.59526569
171Abnormality of transition element cation homeostasis (HP:0011030)1.58569205
172Posterior subcapsular cataract (HP:0007787)1.58169972
173Increased serum lactate (HP:0002151)1.57578460
174Rhabdomyosarcoma (HP:0002859)1.57484116
175Metaphyseal cupping (HP:0003021)1.57237252
176Abnormality of the lower motor neuron (HP:0002366)1.56531261
177Abnormality of the distal phalanges of the toes (HP:0010182)1.56459960
178Abnormality of the calcaneus (HP:0008364)1.56069058
179Abnormalities of placenta or umbilical cord (HP:0001194)1.56046623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.34881855
2WEE13.43779746
3SMG13.06547583
4EPHA23.02205981
5EIF2AK12.99893336
6VRK22.80779726
7TESK22.59219458
8NEK22.49386620
9NEK12.36523207
10NME22.20703866
11TSSK62.19467365
12BCKDK2.13704910
13TTK2.08814261
14MAP3K111.97476877
15TRIB31.93717501
16PLK41.92565452
17CDC71.84923918
18SIK11.78162438
19ERN11.73272740
20STK161.65400378
21PBK1.64540453
22MST1R1.63754557
23KDR1.61172470
24PLK11.60554913
25DYRK31.51730711
26RPS6KA41.51052189
27ACVR1B1.49872773
28PIM21.49665196
29MAP3K101.46009609
30MAP3K81.43909570
31TESK11.41967637
32CDK71.40844057
33PRPF4B1.40547209
34SRPK11.38517036
35PAK41.33680198
36BRSK21.32464973
37CDK41.26520630
38RPS6KB21.25623539
39PKN21.23809456
40AURKA1.21935022
41AURKB1.21415862
42LATS21.20698983
43CDK121.20653108
44EIF2AK31.19904114
45STK101.15493990
46SCYL21.15303009
47BRSK11.07718477
48MAP4K11.07292756
49STK38L1.04567257
50LMTK21.04094872
51MAP2K31.03505821
52TAOK11.02047519
53DAPK11.01319249
54TAOK20.99304950
55CHEK20.98835123
56ATR0.98712083
57MAP3K30.94676389
58MAPKAPK30.93909972
59BRAF0.92055713
60EEF2K0.90925150
61PAK10.90579877
62PTK20.86451572
63SIK30.85646620
64ZAK0.85441297
65PLK30.83361798
66ZAP700.83132124
67LRRK20.80284447
68PIM10.79689103
69IRAK30.78569362
70PRKCI0.78297159
71MAP3K120.76967022
72CHEK10.76511460
73ICK0.76187833
74CDK80.75555222
75ABL20.72431805
76MTOR0.71779026
77PDK30.71036787
78PDK40.71036787
79ALK0.70919804
80AKT30.70916767
81MAP2K20.70416340
82PASK0.70289450
83ARAF0.68343970
84STK40.66942778
85IRAK20.66347435
86DAPK30.63050118
87TLK10.60387421
88BLK0.60252171
89CDK20.59057302
90MET0.58926118
91FLT30.58659443
92MAP3K10.57528361
93MOS0.56429201
94BMX0.55944244
95MUSK0.55768687
96TTN0.55417089
97ILK0.54493368
98CSNK2A10.51981942
99NME10.51767457
100CSNK2A20.51354334
101MAP3K50.50212866
102AKT20.49614555
103RIPK10.49587529
104LIMK10.49148236
105PINK10.48896299
106PRKD30.48693176
107MAPK110.47082686
108PTK60.47059210
109IRAK40.46287036
110GRK60.44809783
111CDK90.44286364
112CAMK2G0.44059857
113STK30.42728421
114TGFBR10.41882527
115FGFR40.41543423
116CDK60.39397477
117MAPKAPK20.39074656
118DYRK20.38705307
119VRK10.38501605
120ATM0.38429152
121PRKG20.37443511
122EPHB10.36456476
123CDK11A0.36355939
124TYK20.36180414
125PDGFRA0.35886073
126CLK10.35724104
127CDK140.34203174
128PDPK10.33682280
129ERBB40.33401564
130TBK10.33165458
131CDK150.32576885
132RPS6KA10.32452838
133CSNK1G30.32362614
134PDK20.30622165
135CDK10.29400729

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.83696775
2DNA replication_Homo sapiens_hsa030303.46633286
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22323488
4RNA polymerase_Homo sapiens_hsa030203.00641018
5Mismatch repair_Homo sapiens_hsa034302.68903570
6RNA transport_Homo sapiens_hsa030132.68501308
7Spliceosome_Homo sapiens_hsa030402.48872781
8One carbon pool by folate_Homo sapiens_hsa006702.44085706
9Ribosome_Homo sapiens_hsa030102.37190527
10Base excision repair_Homo sapiens_hsa034102.34064012
11Pyrimidine metabolism_Homo sapiens_hsa002402.20486211
12Vitamin B6 metabolism_Homo sapiens_hsa007502.17237982
13Other glycan degradation_Homo sapiens_hsa005112.08123131
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07826217
15Folate biosynthesis_Homo sapiens_hsa007902.01591245
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97433248
17Cell cycle_Homo sapiens_hsa041101.85973633
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84222389
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84197787
20Biosynthesis of amino acids_Homo sapiens_hsa012301.78696612
21Nucleotide excision repair_Homo sapiens_hsa034201.76944137
22Sulfur relay system_Homo sapiens_hsa041221.76731638
23Homologous recombination_Homo sapiens_hsa034401.75010057
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.71684884
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.64718928
26Pentose phosphate pathway_Homo sapiens_hsa000301.59613439
27Selenocompound metabolism_Homo sapiens_hsa004501.58365226
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51285676
29Carbon metabolism_Homo sapiens_hsa012001.47664406
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45534839
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44103640
32Vibrio cholerae infection_Homo sapiens_hsa051101.37339870
33p53 signaling pathway_Homo sapiens_hsa041151.33973628
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.33937032
35Fatty acid elongation_Homo sapiens_hsa000621.33530860
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31203085
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27207084
38Fructose and mannose metabolism_Homo sapiens_hsa000511.26609450
39N-Glycan biosynthesis_Homo sapiens_hsa005101.23317693
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.21173664
41Lysosome_Homo sapiens_hsa041421.16938513
42Epstein-Barr virus infection_Homo sapiens_hsa051691.04716958
43mRNA surveillance pathway_Homo sapiens_hsa030151.02020227
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01527025
45Glutathione metabolism_Homo sapiens_hsa004801.00788961
46Basal transcription factors_Homo sapiens_hsa030220.99691260
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99512402
48RNA degradation_Homo sapiens_hsa030180.99370693
49Parkinsons disease_Homo sapiens_hsa050120.97043972
50Purine metabolism_Homo sapiens_hsa002300.96752201
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95937357
52Oxidative phosphorylation_Homo sapiens_hsa001900.95753709
53Salmonella infection_Homo sapiens_hsa051320.94010409
54Galactose metabolism_Homo sapiens_hsa000520.93298358
55Prion diseases_Homo sapiens_hsa050200.93145300
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91345290
57Fanconi anemia pathway_Homo sapiens_hsa034600.86755309
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.85420706
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84641983
60Sulfur metabolism_Homo sapiens_hsa009200.83646285
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81904329
62Chronic myeloid leukemia_Homo sapiens_hsa052200.78872334
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78295905
64Arginine biosynthesis_Homo sapiens_hsa002200.75527402
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74869103
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74476970
67Arginine and proline metabolism_Homo sapiens_hsa003300.72867216
68Regulation of autophagy_Homo sapiens_hsa041400.71538204
69Fatty acid degradation_Homo sapiens_hsa000710.70798260
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69589557
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69156302
72Non-homologous end-joining_Homo sapiens_hsa034500.69061094
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68755230
74Antigen processing and presentation_Homo sapiens_hsa046120.66099622
75Legionellosis_Homo sapiens_hsa051340.65659532
76Pyruvate metabolism_Homo sapiens_hsa006200.63480310
77Alzheimers disease_Homo sapiens_hsa050100.57008569
78Fat digestion and absorption_Homo sapiens_hsa049750.56794158
79Pancreatic cancer_Homo sapiens_hsa052120.56556368
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55670281
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55456883
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55448643
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55265885
84beta-Alanine metabolism_Homo sapiens_hsa004100.50179751
85Herpes simplex infection_Homo sapiens_hsa051680.49381800
86Tryptophan metabolism_Homo sapiens_hsa003800.49116301
87Peroxisome_Homo sapiens_hsa041460.48884974
88Viral carcinogenesis_Homo sapiens_hsa052030.47242048
89Non-small cell lung cancer_Homo sapiens_hsa052230.46540939
90Systemic lupus erythematosus_Homo sapiens_hsa053220.45596100
91Propanoate metabolism_Homo sapiens_hsa006400.45303223
92Metabolic pathways_Homo sapiens_hsa011000.45298166
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44311037
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44203475
95Tyrosine metabolism_Homo sapiens_hsa003500.43145751
96Phenylalanine metabolism_Homo sapiens_hsa003600.43020866
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41870551
98Apoptosis_Homo sapiens_hsa042100.41856960
99Thyroid cancer_Homo sapiens_hsa052160.41651940
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41596586
101Hepatitis B_Homo sapiens_hsa051610.41430131
102Endocytosis_Homo sapiens_hsa041440.41024062
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.40728434
104Bladder cancer_Homo sapiens_hsa052190.40017273
105Vitamin digestion and absorption_Homo sapiens_hsa049770.39959555
106Insulin signaling pathway_Homo sapiens_hsa049100.39833312
107Oocyte meiosis_Homo sapiens_hsa041140.39744318
108Hepatitis C_Homo sapiens_hsa051600.39207536
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.38752595
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.37578324
111HTLV-I infection_Homo sapiens_hsa051660.37577122
112VEGF signaling pathway_Homo sapiens_hsa043700.34901751
113Fatty acid metabolism_Homo sapiens_hsa012120.33112363
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31779577
115Shigellosis_Homo sapiens_hsa051310.30683724
116PPAR signaling pathway_Homo sapiens_hsa033200.30648121
117Huntingtons disease_Homo sapiens_hsa050160.30082859
118mTOR signaling pathway_Homo sapiens_hsa041500.29653224
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29300331
120Chemical carcinogenesis_Homo sapiens_hsa052040.28883843
121Small cell lung cancer_Homo sapiens_hsa052220.28695895
122Caffeine metabolism_Homo sapiens_hsa002320.28304083
123Proteoglycans in cancer_Homo sapiens_hsa052050.28069922
124Complement and coagulation cascades_Homo sapiens_hsa046100.26294875
125Lysine degradation_Homo sapiens_hsa003100.26256512
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26063696
127Influenza A_Homo sapiens_hsa051640.25601910
128Sphingolipid metabolism_Homo sapiens_hsa006000.25425699
129Acute myeloid leukemia_Homo sapiens_hsa052210.25379453
130TNF signaling pathway_Homo sapiens_hsa046680.24940854
131Butanoate metabolism_Homo sapiens_hsa006500.20636628
132HIF-1 signaling pathway_Homo sapiens_hsa040660.20274714
133Hippo signaling pathway_Homo sapiens_hsa043900.19517957
134Starch and sucrose metabolism_Homo sapiens_hsa005000.17691787
135Retinol metabolism_Homo sapiens_hsa008300.16548736
136Glycerolipid metabolism_Homo sapiens_hsa005610.16402039

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