ADSL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.22475643
2DNA strand elongation involved in DNA replication (GO:0006271)4.96905106
3telomere maintenance via semi-conservative replication (GO:0032201)4.77691865
4DNA strand elongation (GO:0022616)4.75300920
5DNA replication initiation (GO:0006270)4.71385656
6maturation of SSU-rRNA (GO:0030490)4.59659912
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.42357627
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.41000623
9DNA deamination (GO:0045006)4.39839755
10nucleobase biosynthetic process (GO:0046112)4.37952347
11DNA unwinding involved in DNA replication (GO:0006268)4.35842708
12telomere maintenance via recombination (GO:0000722)4.27568211
13viral transcription (GO:0019083)4.26972689
14ribosomal large subunit biogenesis (GO:0042273)4.24199082
15formation of translation preinitiation complex (GO:0001731)4.21987806
16translational termination (GO:0006415)4.18970634
17purine nucleobase biosynthetic process (GO:0009113)4.05204306
18* IMP biosynthetic process (GO:0006188)4.01869378
19ribosomal small subunit biogenesis (GO:0042274)4.00046147
20DNA replication checkpoint (GO:0000076)3.98403290
21ribonucleoprotein complex biogenesis (GO:0022613)3.96180472
22mitotic recombination (GO:0006312)3.95094285
23chaperone-mediated protein transport (GO:0072321)3.90540376
24ribosome biogenesis (GO:0042254)3.90364134
25CENP-A containing nucleosome assembly (GO:0034080)3.88806332
26translational elongation (GO:0006414)3.88495855
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88437767
28ATP synthesis coupled proton transport (GO:0015986)3.88437767
29telomere maintenance via telomere lengthening (GO:0010833)3.81110832
30chromatin remodeling at centromere (GO:0031055)3.80397319
31regulation of mitochondrial translation (GO:0070129)3.71191130
32translational initiation (GO:0006413)3.68861882
33ribosome assembly (GO:0042255)3.68455641
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.63710543
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.63151888
36mitotic metaphase plate congression (GO:0007080)3.62858357
37protein localization to kinetochore (GO:0034501)3.56150879
38pseudouridine synthesis (GO:0001522)3.54551029
39folic acid-containing compound biosynthetic process (GO:0009396)3.52767959
40* IMP metabolic process (GO:0046040)3.52514978
41cotranslational protein targeting to membrane (GO:0006613)3.52144541
42rRNA processing (GO:0006364)3.51350628
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50996051
44protein targeting to ER (GO:0045047)3.50534905
45DNA damage response, detection of DNA damage (GO:0042769)3.49664881
46spliceosomal snRNP assembly (GO:0000387)3.47335281
47cullin deneddylation (GO:0010388)3.46824603
48DNA replication-independent nucleosome assembly (GO:0006336)3.46312134
49DNA replication-independent nucleosome organization (GO:0034724)3.46312134
50rRNA metabolic process (GO:0016072)3.40338034
51proteasome assembly (GO:0043248)3.40150256
52regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.36734165
53mitotic nuclear envelope disassembly (GO:0007077)3.36226410
54DNA replication-dependent nucleosome assembly (GO:0006335)3.34108875
55DNA replication-dependent nucleosome organization (GO:0034723)3.34108875
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.33005439
57establishment of viral latency (GO:0019043)3.32222182
58cellular protein complex disassembly (GO:0043624)3.28529854
59protein localization to endoplasmic reticulum (GO:0070972)3.28298726
60metaphase plate congression (GO:0051310)3.27697138
61protein targeting to mitochondrion (GO:0006626)3.27118319
62viral life cycle (GO:0019058)3.24982624
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18968121
64deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18525250
65viral mRNA export from host cell nucleus (GO:0046784)3.17812331
66mitochondrial respiratory chain complex assembly (GO:0033108)3.17330334
67transcription-coupled nucleotide-excision repair (GO:0006283)3.16849204
68kinetochore organization (GO:0051383)3.16166899
69protein deneddylation (GO:0000338)3.15963132
70establishment of integrated proviral latency (GO:0075713)3.14700428
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14068139
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.14068139
73NADH dehydrogenase complex assembly (GO:0010257)3.14068139
74translation (GO:0006412)3.14003246
75mitotic sister chromatid segregation (GO:0000070)3.12913371
76rRNA modification (GO:0000154)3.09617759
77L-serine metabolic process (GO:0006563)3.09166904
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08638987
79cellular component biogenesis (GO:0044085)3.08223903
80histone exchange (GO:0043486)3.08183850
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08154905
82protein localization to chromosome, centromeric region (GO:0071459)3.07981250
83DNA catabolic process, exonucleolytic (GO:0000738)3.07807500
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.07710682
85establishment of protein localization to mitochondrion (GO:0072655)3.07213178
86protein complex biogenesis (GO:0070271)3.06963734
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06202503
88regulation of mitotic spindle checkpoint (GO:1903504)3.06202503
89nuclear pore organization (GO:0006999)3.05667978
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05535807
91respiratory electron transport chain (GO:0022904)3.04898864
92oxidative phosphorylation (GO:0006119)3.04069650
93telomere maintenance (GO:0000723)3.03922594
94telomere organization (GO:0032200)3.03755239
95nuclear envelope disassembly (GO:0051081)3.03228952
96membrane disassembly (GO:0030397)3.03228952
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03093607
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03001096
99DNA double-strand break processing (GO:0000729)3.02638538
100amino acid activation (GO:0043038)3.02421159
101tRNA aminoacylation (GO:0043039)3.02421159
102mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02035394
103spindle checkpoint (GO:0031577)3.01772361
104protein neddylation (GO:0045116)3.01240340
105protein localization to mitochondrion (GO:0070585)3.00776342
106tRNA aminoacylation for protein translation (GO:0006418)3.00225019
107negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00010475
108kinetochore assembly (GO:0051382)2.98928483
109protein complex disassembly (GO:0043241)2.97947366
110cell cycle G1/S phase transition (GO:0044843)2.97871948
111G1/S transition of mitotic cell cycle (GO:0000082)2.97871948
112DNA duplex unwinding (GO:0032508)2.94040077
113maturation of 5.8S rRNA (GO:0000460)2.93772905
114somatic hypermutation of immunoglobulin genes (GO:0016446)2.93204147
115somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93204147
116establishment of chromosome localization (GO:0051303)2.92547345
117negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.91949513
118negative regulation of ligase activity (GO:0051352)2.91949513
119DNA geometric change (GO:0032392)2.91126086
120transcription elongation from RNA polymerase III promoter (GO:0006385)2.91039931
121termination of RNA polymerase III transcription (GO:0006386)2.91039931
122nuclear-transcribed mRNA catabolic process (GO:0000956)2.88137351
123macromolecular complex disassembly (GO:0032984)2.83868626
124regulation of nuclear cell cycle DNA replication (GO:0033262)2.82170037
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81982614
126termination of RNA polymerase I transcription (GO:0006363)2.81624789
127ncRNA processing (GO:0034470)2.81416658
128intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79769020
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79769020
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79447835
131signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79447835
132signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79447835
133tRNA methylation (GO:0030488)2.79433894
134regulation of double-strand break repair via homologous recombination (GO:0010569)2.79178309
135spliceosomal complex assembly (GO:0000245)2.79172026
136attachment of spindle microtubules to kinetochore (GO:0008608)2.79125342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.52972485
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.53344638
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85203907
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49560129
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41078093
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.15533936
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.06562468
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05764196
9* GABP_17652178_ChIP-ChIP_JURKAT_Human3.04460203
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02121587
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96731267
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.91810346
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90176349
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86619720
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66843015
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63002820
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48533323
18* VDR_23849224_ChIP-Seq_CD4+_Human2.34111542
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33240719
20XRN2_22483619_ChIP-Seq_HELA_Human2.32936698
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29048326
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22122469
23FOXP3_21729870_ChIP-Seq_TREG_Human2.13454598
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08716993
25DCP1A_22483619_ChIP-Seq_HELA_Human2.06145147
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04594502
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00847132
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99719947
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91287917
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88391262
31TTF2_22483619_ChIP-Seq_HELA_Human1.88187046
32* GABP_19822575_ChIP-Seq_HepG2_Human1.87570571
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86446605
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83967435
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.83855407
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82082429
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81564341
38AR_21909140_ChIP-Seq_LNCAP_Human1.78500248
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75338293
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75204946
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75053780
42ELK1_19687146_ChIP-ChIP_HELA_Human1.74754023
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.71048520
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.70029681
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66259264
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63500910
47CIITA_25753668_ChIP-Seq_RAJI_Human1.63234140
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63081202
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62803676
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60193478
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.52065797
52* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51854134
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49198041
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46090032
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45674934
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44967590
57* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44388221
58MYC_22102868_ChIP-Seq_BL_Human1.43489613
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.40383100
60KDM5A_27292631_Chip-Seq_BREAST_Human1.34658964
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30992498
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25374189
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23941067
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23737285
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22598733
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.18734490
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17773418
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.16372615
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14480345
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13907836
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11598276
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11229263
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.08647567
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06867521
75* SPI1_23547873_ChIP-Seq_NB4_Human1.06014089
76TFEB_21752829_ChIP-Seq_HELA_Human1.05370963
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04965949
78MYC_18940864_ChIP-ChIP_HL60_Human1.04810782
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04496002
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01685493
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00619110
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00574851
83RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99190499
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98560063
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98535288
86* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98315052
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97737252
88VDR_21846776_ChIP-Seq_THP-1_Human0.95934123
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95075375
90SALL1_21062744_ChIP-ChIP_HESCs_Human0.95000392
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94634434
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94321633
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.92892563
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92510909
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91378765
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90777021
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.88976351
98* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88505815
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87024876
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85402460
101ZNF274_21170338_ChIP-Seq_K562_Hela0.81279313
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80920963
103* EWS_26573619_Chip-Seq_HEK293_Human0.80752708
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79871383
105IRF1_19129219_ChIP-ChIP_H3396_Human0.79693088
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79441697
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77012500
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75979161
109* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74183394
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73818617
111* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73087635
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.71631205
113STAT4_19710469_ChIP-ChIP_TH1__Mouse0.71272662
114FOXP1_21924763_ChIP-Seq_HESCs_Human0.70278757
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.70012597
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70008105
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.69202574
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68018237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.03551869
2MP0010094_abnormal_chromosome_stability4.56358296
3MP0003111_abnormal_nucleus_morphology4.16031815
4MP0004957_abnormal_blastocyst_morpholog3.95385507
5MP0008057_abnormal_DNA_replication3.85475800
6MP0008058_abnormal_DNA_repair3.81873034
7MP0003077_abnormal_cell_cycle3.72911444
8MP0002396_abnormal_hematopoietic_system3.20050248
9MP0008007_abnormal_cellular_replicative3.06107898
10MP0008932_abnormal_embryonic_tissue2.40451857
11MP0004145_abnormal_muscle_electrophysio2.21880840
12MP0003786_premature_aging2.02922336
13MP0001730_embryonic_growth_arrest1.95188187
14MP0008877_abnormal_DNA_methylation1.90057931
15MP0000490_abnormal_crypts_of1.86277984
16MP0000350_abnormal_cell_proliferation1.85715432
17MP0003763_abnormal_thymus_physiology1.80787127
18MP0003123_paternal_imprinting1.76484411
19MP0004808_abnormal_hematopoietic_stem1.72961175
20MP0010352_gastrointestinal_tract_polyps1.67645540
21MP0009333_abnormal_splenocyte_physiolog1.66741226
22MP0002837_dystrophic_cardiac_calcinosis1.51766695
23MP0000313_abnormal_cell_death1.49138990
24MP0001529_abnormal_vocalization1.41279242
25MP0009672_abnormal_birth_weight1.39979714
26MP0002019_abnormal_tumor_incidence1.39146986
27MP0001697_abnormal_embryo_size1.37371649
28MP0003136_yellow_coat_color1.37297718
29MP0001672_abnormal_embryogenesis/_devel1.36734287
30MP0005380_embryogenesis_phenotype1.36734287
31MP0010307_abnormal_tumor_latency1.36635081
32MP0003806_abnormal_nucleotide_metabolis1.35620262
33MP0002398_abnormal_bone_marrow1.34799246
34MP0002080_prenatal_lethality1.32459719
35MP0001835_abnormal_antigen_presentation1.30250727
36MP0006292_abnormal_olfactory_placode1.29641248
37MP0002132_abnormal_respiratory_system1.29545914
38MP0000703_abnormal_thymus_morphology1.28493082
39MP0004233_abnormal_muscle_weight1.28272457
40MP0003984_embryonic_growth_retardation1.27250326
41MP0002722_abnormal_immune_system1.26194287
42MP0001545_abnormal_hematopoietic_system1.24893354
43MP0005397_hematopoietic_system_phenotyp1.24893354
44MP0000689_abnormal_spleen_morphology1.24068058
45MP0001188_hyperpigmentation1.23265016
46MP0002088_abnormal_embryonic_growth/wei1.22672717
47MP0003567_abnormal_fetal_cardiomyocyte1.19628062
48MP0001853_heart_inflammation1.19315862
49MP0002163_abnormal_gland_morphology1.18614514
50MP0001661_extended_life_span1.16490365
51MP0003718_maternal_effect1.16105275
52MP0003186_abnormal_redox_activity1.16005706
53MP0005075_abnormal_melanosome_morpholog1.15182478
54MP0009379_abnormal_foot_pigmentation1.14157090
55MP0003937_abnormal_limbs/digits/tail_de1.12334708
56MP0000751_myopathy1.11769769
57MP0001293_anophthalmia1.10151837
58MP0008789_abnormal_olfactory_epithelium1.09823714
59MP0005671_abnormal_response_to1.09046237
60MP0002429_abnormal_blood_cell1.08624163
61MP0002085_abnormal_embryonic_tissue1.07733456
62MP0005330_cardiomyopathy1.07001550
63MP0006036_abnormal_mitochondrial_physio1.04944599
64MP0004147_increased_porphyrin_level1.03536831
65MP0000049_abnormal_middle_ear1.00339130
66MP0004197_abnormal_fetal_growth/weight/0.99906844
67MP0002086_abnormal_extraembryonic_tissu0.98232293
68MP0002095_abnormal_skin_pigmentation0.97716767
69MP0002210_abnormal_sex_determination0.97426978
70MP0000716_abnormal_immune_system0.97405955
71MP0002106_abnormal_muscle_physiology0.97140041
72MP0004036_abnormal_muscle_relaxation0.96915660
73MP0003221_abnormal_cardiomyocyte_apopto0.96707200
74MP0000747_muscle_weakness0.96346989
75MP0003646_muscle_fatigue0.95893685
76MP0003121_genomic_imprinting0.94150615
77MP0006054_spinal_hemorrhage0.93922203
78MP0001800_abnormal_humoral_immune0.92413572
79MP0002084_abnormal_developmental_patter0.91780903
80MP0000358_abnormal_cell_content/0.91415061
81MP0003315_abnormal_perineum_morphology0.91059751
82MP0004084_abnormal_cardiac_muscle0.89857108
83MP0000749_muscle_degeneration0.89741255
84MP0000858_altered_metastatic_potential0.89322425
85MP0006072_abnormal_retinal_apoptosis0.88756959
86MP0009697_abnormal_copulation0.88690831
87MP0002420_abnormal_adaptive_immunity0.87856091
88MP0005084_abnormal_gallbladder_morpholo0.86714179
89MP0002160_abnormal_reproductive_system0.86687157
90MP0009785_altered_susceptibility_to0.86244776
91MP0001819_abnormal_immune_cell0.85975957
92MP0010030_abnormal_orbit_morphology0.85719240
93MP0002452_abnormal_antigen_presenting0.84475351
94MP0000750_abnormal_muscle_regeneration0.84159212
95MP0004215_abnormal_myocardial_fiber0.82753949
96MP0003941_abnormal_skin_development0.82486509
97MP0005369_muscle_phenotype0.81970878
98MP0001145_abnormal_male_reproductive0.81606984
99MP0004087_abnormal_muscle_fiber0.80685403
100MP0001286_abnormal_eye_development0.80677043
101MP0000759_abnormal_skeletal_muscle0.78583549
102MP0005408_hypopigmentation0.78128342
103MP0001873_stomach_inflammation0.77002738
104MP0003698_abnormal_male_reproductive0.76852309
105MP0004133_heterotaxia0.76691211
106MP0002405_respiratory_system_inflammati0.75628852
107MP0006035_abnormal_mitochondrial_morpho0.74993891
108MP0002723_abnormal_immune_serum0.74815095
109MP0002697_abnormal_eye_size0.74594372
110MP0000685_abnormal_immune_system0.73991149
111MP0005174_abnormal_tail_pigmentation0.72063545
112MP0003119_abnormal_digestive_system0.71024478
113MP0001119_abnormal_female_reproductive0.70806649
114MP0002148_abnormal_hypersensitivity_rea0.70689110
115MP0000465_gastrointestinal_hemorrhage0.69457611
116MP0005266_abnormal_metabolism0.69095094
117MP0005025_abnormal_response_to0.68903550
118MP0002102_abnormal_ear_morphology0.67689409
119MP0000653_abnormal_sex_gland0.66172379
120MP0002111_abnormal_tail_morphology0.65922563
121MP0005384_cellular_phenotype0.65778010
122MP0001929_abnormal_gametogenesis0.65487557
123MP0002075_abnormal_coat/hair_pigmentati0.64213488
124MP0001764_abnormal_homeostasis0.63615297
125MP0002233_abnormal_nose_morphology0.62524594
126MP0001485_abnormal_pinna_reflex0.62059793
127MP0002938_white_spotting0.61804235
128MP0009250_abnormal_appendicular_skeleto0.61692199
129MP0002269_muscular_atrophy0.61642999
130MP0002161_abnormal_fertility/fecundity0.60553366
131MP0002234_abnormal_pharynx_morphology0.59502108
132MP0005379_endocrine/exocrine_gland_phen0.59239419
133MP0005389_reproductive_system_phenotype0.58331602
134MP0003890_abnormal_embryonic-extraembry0.58232661
135MP0010155_abnormal_intestine_physiology0.57903785
136MP0000372_irregular_coat_pigmentation0.57689966

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.89988528
2Reticulocytopenia (HP:0001896)4.84759584
3Abnormality of cells of the erythroid lineage (HP:0012130)4.71577142
4Abnormal number of erythroid precursors (HP:0012131)4.58421385
5Acute necrotizing encephalopathy (HP:0006965)4.24862734
6Acute encephalopathy (HP:0006846)3.96602730
7Abnormal mitochondria in muscle tissue (HP:0008316)3.95365769
8Chromsome breakage (HP:0040012)3.93013775
9Nemaline bodies (HP:0003798)3.77914264
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.74343970
11Aplastic anemia (HP:0001915)3.73894489
12Muscle fiber inclusion bodies (HP:0100299)3.71156362
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.64333365
14Oral leukoplakia (HP:0002745)3.51652943
15Progressive macrocephaly (HP:0004481)3.32314610
16Selective tooth agenesis (HP:0001592)3.29902488
17Macrocytic anemia (HP:0001972)3.26723860
18Lipid accumulation in hepatocytes (HP:0006561)3.23633024
19Breast hypoplasia (HP:0003187)3.15320149
20Abnormality of the preputium (HP:0100587)3.12216159
21Cerebral edema (HP:0002181)3.10332177
22Pallor (HP:0000980)3.10221431
23Increased serum pyruvate (HP:0003542)3.07505883
24Colon cancer (HP:0003003)3.06583510
25Exercise-induced muscle cramps (HP:0003710)2.94662368
26Meckel diverticulum (HP:0002245)2.94635918
27Abnormality of chromosome stability (HP:0003220)2.94514766
28Hepatic necrosis (HP:0002605)2.94198372
29Abnormality of the labia minora (HP:0012880)2.92991737
30Abnormality of glycolysis (HP:0004366)2.89597401
31Thrombocytosis (HP:0001894)2.88212135
32Medulloblastoma (HP:0002885)2.82406629
33Absent thumb (HP:0009777)2.81345099
34Abnormality of the ileum (HP:0001549)2.78536005
35Lactic acidosis (HP:0003128)2.76948953
36Increased intramyocellular lipid droplets (HP:0012240)2.76278723
37Myelodysplasia (HP:0002863)2.75391986
38Patellar aplasia (HP:0006443)2.71020699
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.68098460
40Rough bone trabeculation (HP:0100670)2.67507154
4111 pairs of ribs (HP:0000878)2.65016616
42Premature graying of hair (HP:0002216)2.56185886
43Aplasia/Hypoplasia of the patella (HP:0006498)2.52113254
44Bone marrow hypocellularity (HP:0005528)2.50669022
45Abnormal number of incisors (HP:0011064)2.50097452
46Duplicated collecting system (HP:0000081)2.49986464
47Type 2 muscle fiber atrophy (HP:0003554)2.49301872
48Pancytopenia (HP:0001876)2.47421958
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.46896091
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.46896091
51Muscle fiber atrophy (HP:0100295)2.46598371
52Agnosia (HP:0010524)2.46480529
53IgM deficiency (HP:0002850)2.46368011
54Abnormality of the renal collecting system (HP:0004742)2.40783915
55Renal Fanconi syndrome (HP:0001994)2.40729668
56Degeneration of anterior horn cells (HP:0002398)2.39160926
57Abnormality of the anterior horn cell (HP:0006802)2.39160926
58Type I transferrin isoform profile (HP:0003642)2.38595298
59Microvesicular hepatic steatosis (HP:0001414)2.38205306
60Microretrognathia (HP:0000308)2.37646978
61Increased serum lactate (HP:0002151)2.37325704
62Abnormality of serum amino acid levels (HP:0003112)2.35946038
63Increased muscle lipid content (HP:0009058)2.23903175
64Lymphoma (HP:0002665)2.23895281
65Neoplasm of the pancreas (HP:0002894)2.20151112
66Abnormality of methionine metabolism (HP:0010901)2.19785681
67Amaurosis fugax (HP:0100576)2.19667332
68Duodenal stenosis (HP:0100867)2.19584315
69Small intestinal stenosis (HP:0012848)2.19584315
70Carpal bone hypoplasia (HP:0001498)2.19216895
71Trismus (HP:0000211)2.18883279
72Cellular immunodeficiency (HP:0005374)2.17715312
73Hyperglycinemia (HP:0002154)2.17424669
74Respiratory failure (HP:0002878)2.16792505
75Respiratory difficulties (HP:0002880)2.15593456
76Leukodystrophy (HP:0002415)2.15180712
77Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14828347
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12988921
79Abnormality of alanine metabolism (HP:0010916)2.12988921
80Hyperalaninemia (HP:0003348)2.12988921
81Ectopic kidney (HP:0000086)2.10607030
82Progressive muscle weakness (HP:0003323)2.10158136
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09702642
84Abnormal protein N-linked glycosylation (HP:0012347)2.09702642
85Abnormal protein glycosylation (HP:0012346)2.09702642
86Abnormal glycosylation (HP:0012345)2.09702642
87Sloping forehead (HP:0000340)2.09586015
88Abnormal lung lobation (HP:0002101)2.09099175
89Ependymoma (HP:0002888)2.07956112
90Tracheoesophageal fistula (HP:0002575)2.07786199
91Distal arthrogryposis (HP:0005684)2.07036666
92Multiple enchondromatosis (HP:0005701)2.06832482
93Abnormality of DNA repair (HP:0003254)2.06301367
94Muscle hypertrophy of the lower extremities (HP:0008968)2.04770512
95Asplenia (HP:0001746)2.03682000
96Hypoplasia of the pons (HP:0012110)2.01501528
97Triphalangeal thumb (HP:0001199)2.01225784
98Absent radius (HP:0003974)2.00828690
99Slender long bone (HP:0003100)1.98042505
100Methylmalonic acidemia (HP:0002912)1.97371824
101Rimmed vacuoles (HP:0003805)1.97030234
102Deformed tarsal bones (HP:0008119)1.96786134
103Basal cell carcinoma (HP:0002671)1.95672920
104Abnormality of the pons (HP:0007361)1.95532019
105Abnormal trabecular bone morphology (HP:0100671)1.94702249
106Squamous cell carcinoma (HP:0002860)1.94582436
107Increased CSF lactate (HP:0002490)1.93386136
108Hyperglycinuria (HP:0003108)1.93202329
109Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91385010
110Exertional dyspnea (HP:0002875)1.91257106
111Horseshoe kidney (HP:0000085)1.90252524
112Impulsivity (HP:0100710)1.89486814
113Cleft eyelid (HP:0000625)1.89428300
114Methylmalonic aciduria (HP:0012120)1.88491559
115Lethargy (HP:0001254)1.87990069
116Clubbing of toes (HP:0100760)1.87901696
117Calf muscle hypertrophy (HP:0008981)1.87763094
118Rhabdomyolysis (HP:0003201)1.87609372
119Abnormality of reticulocytes (HP:0004312)1.87236212
120Nephroblastoma (Wilms tumor) (HP:0002667)1.86368774
121Hepatocellular necrosis (HP:0001404)1.86350163
122Exercise intolerance (HP:0003546)1.86092409
123Megaloblastic anemia (HP:0001889)1.85609167
124Increased hepatocellular lipid droplets (HP:0006565)1.85140759
125Reduced antithrombin III activity (HP:0001976)1.85121014
126Optic nerve coloboma (HP:0000588)1.85078668
127Facial cleft (HP:0002006)1.84640226
128Aplasia/Hypoplasia of the spleen (HP:0010451)1.83840933
129Aplasia involving forearm bones (HP:0009822)1.82980411
130Absent forearm bone (HP:0003953)1.82980411
131Amniotic constriction ring (HP:0009775)1.82797595
132Abnormality of placental membranes (HP:0011409)1.82797595
133Optic disc pallor (HP:0000543)1.82762662
134Abnormality of serine family amino acid metabolism (HP:0010894)1.82414518
135Abnormality of glycine metabolism (HP:0010895)1.82414518
1363-Methylglutaconic aciduria (HP:0003535)1.81377077
137Neoplasm of the adrenal gland (HP:0100631)1.81366591
138Supernumerary spleens (HP:0009799)1.81297108
139Rhabdomyosarcoma (HP:0002859)1.81285809
140Abnormality of the carotid arteries (HP:0005344)1.80901749
141Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79678563
142Abnormality of the duodenum (HP:0002246)1.78419558
143Mitochondrial inheritance (HP:0001427)1.77680722
144Calcaneovalgus deformity (HP:0001848)1.75890148
145Abnormality of the heme biosynthetic pathway (HP:0010472)1.75431166
146Neoplasm of the colon (HP:0100273)1.74167560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.12886071
2WEE13.71896046
3CDC73.64769177
4VRK23.58059114
5EIF2AK13.26160520
6STK163.16931711
7NME22.57960142
8TSSK62.41705824
9SRPK12.39261810
10ACVR1B2.24920589
11EIF2AK32.21501834
12NEK22.09802150
13PLK42.08522961
14BRSK22.08456607
15VRK12.01581142
16NEK11.97067221
17MKNK11.95037990
18TLK11.86536198
19TAF11.86299359
20TTK1.77791980
21PLK11.71442449
22ZAK1.68910025
23ATR1.65906121
24NUAK11.63227343
25PASK1.59704648
26CDK71.56983681
27TGFBR11.56817645
28AURKB1.54314551
29MKNK21.54043527
30RPS6KB21.46850356
31RPS6KA41.46661504
32TESK21.45782754
33DYRK31.36123448
34MAP4K11.34502794
35PIM21.23910740
36EEF2K1.23371990
37FLT31.17895982
38CDK191.17746458
39TRIM281.15930692
40PLK31.15916720
41EIF2AK21.15556310
42BRSK11.15034483
43CCNB11.08864336
44CDK81.07481939
45SCYL21.06186552
46BMPR1B1.05240468
47OBSCN1.02503295
48CHEK21.02031336
49AURKA1.01038650
50KDR1.00990588
51CDK40.97824064
52STK40.96177675
53PBK0.96120192
54CHEK10.96052131
55IRAK40.90527410
56STK100.90342117
57KIT0.89896634
58PHKG20.88655910
59PHKG10.88655910
60PINK10.88352845
61MAP3K80.88002903
62TEC0.87732624
63PAK40.87387295
64BCKDK0.86047728
65BLK0.85079375
66DYRK20.83957044
67PIM10.83413143
68TNIK0.83203868
69MAP2K30.83043178
70CSNK1G10.79338838
71PNCK0.79077346
72BTK0.75919286
73NME10.75707061
74IRAK30.74709099
75JAK30.74138777
76MAP4K20.72623364
77ATM0.71598415
78EPHA20.71570013
79CSNK2A20.71525037
80WNK30.71461926
81TXK0.71272314
82CSNK2A10.69787659
83CDK20.62426807
84CSNK1G30.61769201
85TTN0.61446538
86MST40.61107513
87CLK10.59899418
88RPS6KA50.57235801
89PIK3CG0.56795058
90BRD40.56230911
91MAP3K110.55818657
92ZAP700.55286879
93NLK0.54418231
94MAPKAPK30.54314025
95ARAF0.54173727
96PAK10.53591524
97SMG10.53228455
98TAOK20.53158993
99PKN20.50710110
100LRRK20.50659681
101WNK40.50050634
102TIE10.49461473
103INSRR0.48903416
104NEK90.47920891
105ILK0.46761684
106CDK120.45326655
107IKBKB0.44659802
108DAPK10.44206678
109STK30.44181576
110CSNK1A1L0.42840991
111TESK10.42294100
112CDK10.42099756
113CSNK1G20.40438340
114CSF1R0.39795095
115MAP3K100.38569143
116MAPKAPK50.37803448
117LYN0.37323713
118CSNK1E0.36859587
119BRAF0.35165989
120YES10.34785422
121PDK20.33888228
122STK38L0.33629693
123MAP3K90.33320634
124PRKCI0.33238590
125PDK30.33018089
126PDK40.33018089
127ERBB40.32828575
128PRKDC0.32740591
129ALK0.32711841
130STK240.32346790
131TYK20.32013344
132AKT20.31307351
133MUSK0.30738984
134GRK10.24626327
135OXSR10.24603707
136CDK30.22314363
137DAPK30.21787233

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.01331111
2Mismatch repair_Homo sapiens_hsa034304.13912450
3Ribosome_Homo sapiens_hsa030103.91096790
4Proteasome_Homo sapiens_hsa030503.47603195
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37488107
6RNA polymerase_Homo sapiens_hsa030203.21907700
7Homologous recombination_Homo sapiens_hsa034403.10741294
8Spliceosome_Homo sapiens_hsa030403.09444321
9Base excision repair_Homo sapiens_hsa034103.03518447
10Nucleotide excision repair_Homo sapiens_hsa034202.86211645
11RNA transport_Homo sapiens_hsa030132.68650020
12One carbon pool by folate_Homo sapiens_hsa006702.62288766
13Pyrimidine metabolism_Homo sapiens_hsa002402.54013101
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49721446
15Fanconi anemia pathway_Homo sapiens_hsa034602.25045617
16Cell cycle_Homo sapiens_hsa041102.24906370
17Non-homologous end-joining_Homo sapiens_hsa034502.18653444
18RNA degradation_Homo sapiens_hsa030181.82575419
19Basal transcription factors_Homo sapiens_hsa030221.77031203
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60443645
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53098050
22Propanoate metabolism_Homo sapiens_hsa006401.49616659
23Pyruvate metabolism_Homo sapiens_hsa006201.48346276
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45249411
25* Purine metabolism_Homo sapiens_hsa002301.38698726
26mRNA surveillance pathway_Homo sapiens_hsa030151.34357015
27p53 signaling pathway_Homo sapiens_hsa041151.33057745
28Cardiac muscle contraction_Homo sapiens_hsa042601.24387790
29Epstein-Barr virus infection_Homo sapiens_hsa051691.14647701
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14516084
31Systemic lupus erythematosus_Homo sapiens_hsa053221.10621173
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07520524
33Herpes simplex infection_Homo sapiens_hsa051681.03604013
34Protein export_Homo sapiens_hsa030600.99256522
35Antigen processing and presentation_Homo sapiens_hsa046120.96733556
36Primary immunodeficiency_Homo sapiens_hsa053400.95072069
37Fatty acid elongation_Homo sapiens_hsa000620.93854339
38Parkinsons disease_Homo sapiens_hsa050120.89501116
39Biosynthesis of amino acids_Homo sapiens_hsa012300.86335198
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85769310
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85186853
42Folate biosynthesis_Homo sapiens_hsa007900.84576838
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83611601
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.83186434
45Huntingtons disease_Homo sapiens_hsa050160.82178434
46Pentose phosphate pathway_Homo sapiens_hsa000300.81158578
47Viral carcinogenesis_Homo sapiens_hsa052030.80967314
48Legionellosis_Homo sapiens_hsa051340.76892019
49Sulfur relay system_Homo sapiens_hsa041220.72365262
50Steroid biosynthesis_Homo sapiens_hsa001000.70589590
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.69002850
52Measles_Homo sapiens_hsa051620.68187303
53HTLV-I infection_Homo sapiens_hsa051660.66329680
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64979393
55Oxidative phosphorylation_Homo sapiens_hsa001900.63997785
56Carbon metabolism_Homo sapiens_hsa012000.61529979
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58362993
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.57965502
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56999274
60Allograft rejection_Homo sapiens_hsa053300.56442735
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.56333428
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55669450
63Selenocompound metabolism_Homo sapiens_hsa004500.53386226
64Peroxisome_Homo sapiens_hsa041460.49991038
65N-Glycan biosynthesis_Homo sapiens_hsa005100.48739918
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48358747
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48124813
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.46544271
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46117042
70Apoptosis_Homo sapiens_hsa042100.45530861
71Butanoate metabolism_Homo sapiens_hsa006500.45474402
72Thyroid cancer_Homo sapiens_hsa052160.45128825
73Small cell lung cancer_Homo sapiens_hsa052220.45124495
74Hematopoietic cell lineage_Homo sapiens_hsa046400.45056820
75Glutathione metabolism_Homo sapiens_hsa004800.43109086
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41785587
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41217103
78Fructose and mannose metabolism_Homo sapiens_hsa000510.41197777
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39602863
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39484419
81Fatty acid degradation_Homo sapiens_hsa000710.38263446
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38043071
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37657371
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37593051
85Fatty acid metabolism_Homo sapiens_hsa012120.37546947
86Asthma_Homo sapiens_hsa053100.37305090
87* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36418844
88Viral myocarditis_Homo sapiens_hsa054160.35560342
89Regulation of autophagy_Homo sapiens_hsa041400.35469999
90Oocyte meiosis_Homo sapiens_hsa041140.35136689
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34159162
92Galactose metabolism_Homo sapiens_hsa000520.33882712
93Influenza A_Homo sapiens_hsa051640.33813693
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31651212
95* Metabolic pathways_Homo sapiens_hsa011000.29319731
96HIF-1 signaling pathway_Homo sapiens_hsa040660.27981424
97Hepatitis B_Homo sapiens_hsa051610.27426681
98beta-Alanine metabolism_Homo sapiens_hsa004100.26782815
99Leishmaniasis_Homo sapiens_hsa051400.26249551
100Arginine biosynthesis_Homo sapiens_hsa002200.25898575
101Basal cell carcinoma_Homo sapiens_hsa052170.25883374
102Sulfur metabolism_Homo sapiens_hsa009200.25548133
103Graft-versus-host disease_Homo sapiens_hsa053320.25407343
104Acute myeloid leukemia_Homo sapiens_hsa052210.24593276
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24346043
106Autoimmune thyroid disease_Homo sapiens_hsa053200.24205105
107Other glycan degradation_Homo sapiens_hsa005110.24110874
108Nitrogen metabolism_Homo sapiens_hsa009100.23500214
109MicroRNAs in cancer_Homo sapiens_hsa052060.23348795
110Alzheimers disease_Homo sapiens_hsa050100.23313920
111Arachidonic acid metabolism_Homo sapiens_hsa005900.22963306
112Vitamin digestion and absorption_Homo sapiens_hsa049770.22726982
113Alcoholism_Homo sapiens_hsa050340.22368832
114Vitamin B6 metabolism_Homo sapiens_hsa007500.21973814
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.21939029
116Tryptophan metabolism_Homo sapiens_hsa003800.21551429
117Shigellosis_Homo sapiens_hsa051310.19996375
118Notch signaling pathway_Homo sapiens_hsa043300.19495446
119Hedgehog signaling pathway_Homo sapiens_hsa043400.17509759
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17147507
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16979650
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16402883
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.15595352
124Arginine and proline metabolism_Homo sapiens_hsa003300.13776634
125Type I diabetes mellitus_Homo sapiens_hsa049400.13601054
126TGF-beta signaling pathway_Homo sapiens_hsa043500.12621782
127Phototransduction_Homo sapiens_hsa047440.12158176
128Colorectal cancer_Homo sapiens_hsa052100.11587609
129Wnt signaling pathway_Homo sapiens_hsa043100.11157641
130Tyrosine metabolism_Homo sapiens_hsa003500.11033390
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09555731
132Hippo signaling pathway_Homo sapiens_hsa043900.08461498
133Lysine degradation_Homo sapiens_hsa003100.07740811
134Starch and sucrose metabolism_Homo sapiens_hsa005000.05310251
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.03934274

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