ADSS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.13077221
2nuclear pore complex assembly (GO:0051292)4.81934796
3nuclear pore organization (GO:0006999)4.77792250
4DNA unwinding involved in DNA replication (GO:0006268)4.72026929
5mitotic nuclear envelope disassembly (GO:0007077)4.46076812
6mitotic metaphase plate congression (GO:0007080)4.44926350
7protein localization to chromosome, centromeric region (GO:0071459)4.34457899
8mitotic chromosome condensation (GO:0007076)4.30431790
9membrane disassembly (GO:0030397)4.24133370
10nuclear envelope disassembly (GO:0051081)4.24133370
11DNA replication initiation (GO:0006270)4.22197717
12establishment of integrated proviral latency (GO:0075713)4.19096080
13folic acid-containing compound biosynthetic process (GO:0009396)4.14095124
14mitotic sister chromatid cohesion (GO:0007064)3.98164106
15DNA strand elongation involved in DNA replication (GO:0006271)3.97771090
16metaphase plate congression (GO:0051310)3.92346483
17protein complex localization (GO:0031503)3.92000343
18ribosome assembly (GO:0042255)3.88640555
19mitotic sister chromatid segregation (GO:0000070)3.83218720
20cellular protein complex localization (GO:0034629)3.81173527
21formation of translation preinitiation complex (GO:0001731)3.80828435
22DNA replication-dependent nucleosome assembly (GO:0006335)3.80237472
23DNA replication-dependent nucleosome organization (GO:0034723)3.80237472
24DNA strand elongation (GO:0022616)3.75266638
25attachment of spindle microtubules to kinetochore (GO:0008608)3.75203911
26chromatin remodeling at centromere (GO:0031055)3.75090575
27CENP-A containing nucleosome assembly (GO:0034080)3.74094919
28IMP biosynthetic process (GO:0006188)3.72978183
29establishment of chromosome localization (GO:0051303)3.72069320
30regulation of spindle organization (GO:0090224)3.68222308
31sister chromatid segregation (GO:0000819)3.67698265
32maturation of SSU-rRNA (GO:0030490)3.57932692
33DNA replication checkpoint (GO:0000076)3.57618864
34nucleobase biosynthetic process (GO:0046112)3.52286451
35regulation of translational termination (GO:0006449)3.51217970
36pore complex assembly (GO:0046931)3.50199587
37pre-miRNA processing (GO:0031054)3.49958933
38DNA replication-independent nucleosome organization (GO:0034724)3.47171188
39DNA replication-independent nucleosome assembly (GO:0006336)3.47171188
40establishment of viral latency (GO:0019043)3.46358721
41DNA topological change (GO:0006265)3.45514019
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.44296757
43regulation of histone H3-K9 methylation (GO:0051570)3.44284436
44DNA duplex unwinding (GO:0032508)3.41210609
45kinetochore organization (GO:0051383)3.40902179
46negative regulation of histone methylation (GO:0031061)3.40062402
47DNA geometric change (GO:0032392)3.39413769
48telomere maintenance via semi-conservative replication (GO:0032201)3.38380041
49regulation of sister chromatid cohesion (GO:0007063)3.35501761
50purine nucleobase biosynthetic process (GO:0009113)3.32895092
51histone exchange (GO:0043486)3.31423870
52regulation of centrosome cycle (GO:0046605)3.28956594
53nuclear envelope organization (GO:0006998)3.25080193
54regulation of RNA export from nucleus (GO:0046831)3.23312074
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23145310
56protein localization to endosome (GO:0036010)3.22648376
57telomere maintenance via recombination (GO:0000722)3.21348774
58mRNA stabilization (GO:0048255)3.18718417
59RNA stabilization (GO:0043489)3.18718417
60mitotic recombination (GO:0006312)3.18693490
61regulation of chromosome segregation (GO:0051983)3.18603104
62spindle checkpoint (GO:0031577)3.18122763
63positive regulation of chromosome segregation (GO:0051984)3.15841185
64protein localization to chromosome (GO:0034502)3.15408570
65regulation of mitotic spindle organization (GO:0060236)3.14770671
66regulation of translational fidelity (GO:0006450)3.14229281
67negative regulation of chromosome segregation (GO:0051985)3.13577657
68regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13427715
69negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12483461
70negative regulation of sister chromatid segregation (GO:0033046)3.12483461
71negative regulation of mitotic sister chromatid separation (GO:2000816)3.12483461
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12483461
73meiotic chromosome segregation (GO:0045132)3.12448999
74ribosomal small subunit assembly (GO:0000028)3.12146402
75chromatin assembly or disassembly (GO:0006333)3.11768497
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.11461403
77regulation of centriole replication (GO:0046599)3.10774524
78ribosome biogenesis (GO:0042254)3.10609693
79positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10480247
80positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10480247
81positive regulation of mitotic sister chromatid separation (GO:1901970)3.10480247
82* IMP metabolic process (GO:0046040)3.10215459
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09966594
84spindle assembly checkpoint (GO:0071173)3.08875169
85COPI coating of Golgi vesicle (GO:0048205)3.08340928
86Golgi transport vesicle coating (GO:0048200)3.08340928
87protein export from nucleus (GO:0006611)3.07349042
88mitotic spindle assembly checkpoint (GO:0007094)3.05846006
89regulation of nucleobase-containing compound transport (GO:0032239)3.03219986
90mitotic spindle checkpoint (GO:0071174)3.00384250
91regulation of helicase activity (GO:0051095)3.00301638
92protein K6-linked ubiquitination (GO:0085020)2.95880750
93negative regulation of DNA repair (GO:0045738)2.95347487
94regulation of mitotic sister chromatid separation (GO:0010965)2.94984763
95regulation of mitotic sister chromatid segregation (GO:0033047)2.94984763
96regulation of sister chromatid segregation (GO:0033045)2.94984763
97histone H2A monoubiquitination (GO:0035518)2.94501671
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.92990060
99telomere maintenance via telomere lengthening (GO:0010833)2.91140641
100chromosome segregation (GO:0007059)2.90458968
101DNA conformation change (GO:0071103)2.87001316
102ribosomal large subunit biogenesis (GO:0042273)2.85631800
103somatic hypermutation of immunoglobulin genes (GO:0016446)2.84999648
104somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84999648
105heterochromatin organization (GO:0070828)2.84933759
106ribonucleoprotein complex biogenesis (GO:0022613)2.83976412
107translational termination (GO:0006415)2.82241103
108translational initiation (GO:0006413)2.80516826
109histone H2B ubiquitination (GO:0033523)2.77793592
110negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.75075404
111viral transcription (GO:0019083)2.74670464
112ATP-dependent chromatin remodeling (GO:0043044)2.74500391
113rRNA processing (GO:0006364)2.73760840
114somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.73027620
115somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.73027620
116isotype switching (GO:0045190)2.73027620
117histone-serine phosphorylation (GO:0035404)2.70864105
118nucleotide-excision repair, DNA gap filling (GO:0006297)2.69245173
1193-UTR-mediated mRNA stabilization (GO:0070935)2.66912564
120nucleobase-containing small molecule interconversion (GO:0015949)2.64508730
121chromosome condensation (GO:0030261)2.61586335
122DNA synthesis involved in DNA repair (GO:0000731)2.58293061
123spliceosomal tri-snRNP complex assembly (GO:0000244)2.55124065
124double-strand break repair via nonhomologous end joining (GO:0006303)2.53280069
125non-recombinational repair (GO:0000726)2.53280069
126histone H3-K36 demethylation (GO:0070544)2.50785296
127pentose-phosphate shunt (GO:0006098)2.47378456
128negative regulation of mRNA metabolic process (GO:1903312)2.45905188
129epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45829714
130regulation of mRNA stability (GO:0043488)2.44672029
131negative regulation of fibroblast apoptotic process (GO:2000270)2.43019839
132hypotonic response (GO:0006971)2.41785628
133DNA packaging (GO:0006323)2.41561790
134positive regulation of SMAD protein import into nucleus (GO:0060391)2.39793002
135mitotic G2/M transition checkpoint (GO:0044818)2.39557730
136regulation of transcription from RNA polymerase I promoter (GO:0006356)2.38806433
137mRNA transport (GO:0051028)2.37763242
138NADPH regeneration (GO:0006740)2.35257533
139negative regulation of mRNA processing (GO:0050686)2.31021973
140regulation of RNA stability (GO:0043487)2.30109053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.74129931
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.70142298
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.11796921
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02033409
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.44329707
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16303791
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.15040811
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84171007
9* AR_21909140_ChIP-Seq_LNCAP_Human2.70125995
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61167697
11NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33681546
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.31331152
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29087302
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28193470
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.20415272
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19207321
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.16687700
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.03165767
19XRN2_22483619_ChIP-Seq_HELA_Human2.01828926
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.98189916
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96016120
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.95645676
23MYC_22102868_ChIP-Seq_BL_Human1.94802322
24* VDR_23849224_ChIP-Seq_CD4+_Human1.91322475
25* ETS1_20019798_ChIP-Seq_JURKAT_Human1.90032734
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88995136
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84916932
28CLOCK_20551151_ChIP-Seq_293T_Human1.84558249
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84354806
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81317362
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79811813
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79809402
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79024726
34ELK1_19687146_ChIP-ChIP_HELA_Human1.75610726
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73954400
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70716452
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69394517
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66072136
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65749769
40* TTF2_22483619_ChIP-Seq_HELA_Human1.63496856
41FOXP3_21729870_ChIP-Seq_TREG_Human1.62523473
42DCP1A_22483619_ChIP-Seq_HELA_Human1.61752586
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61291616
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59848619
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59518909
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59337439
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58091647
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51324410
49GABP_19822575_ChIP-Seq_HepG2_Human1.51078475
50* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50560457
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46749084
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46310112
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43831631
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43309349
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42150190
56KDM5A_27292631_Chip-Seq_BREAST_Human1.38903144
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37381356
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35418577
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35325388
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34811920
61* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31991351
62* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31768193
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30339559
64CIITA_25753668_ChIP-Seq_RAJI_Human1.29402440
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25936973
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25936973
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25936973
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24988094
69* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24726528
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22164486
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21564064
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19246965
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19191593
74ZNF263_19887448_ChIP-Seq_K562_Human1.17702480
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.16820386
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16332815
77TFEB_21752829_ChIP-Seq_HELA_Human1.14254331
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13858751
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13622047
80* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13045323
81* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12025016
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11941673
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11715540
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.10752368
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09030486
86* MAF_26560356_Chip-Seq_TH1_Human1.08959736
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08502980
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08502980
89* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08055469
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07988430
91MYC_18940864_ChIP-ChIP_HL60_Human1.07296060
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.07007291
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06850467
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06422104
95* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05854735
96TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04148402
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04008654
98SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03543889
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02924863
100* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02070084
101NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01719587
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01155085
103* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00133785
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.99801694
105* SPI1_23547873_ChIP-Seq_NB4_Human0.99666487
106* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97783042
107THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97379263
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97291740
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96793737
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96456690
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96376247
112HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96357095
113EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96094760
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95123676
115TCF7_22412390_ChIP-Seq_EML_Mouse0.94699474
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93555286
117* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93157573
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93004785
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91357066
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91102854
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88441931
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87718984
123MYB_26560356_Chip-Seq_TH1_Human0.86338198
124MYB_26560356_Chip-Seq_TH2_Human0.85214610
125VDR_21846776_ChIP-Seq_THP-1_Human0.85090839
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84122177
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83742283
128NANOG_21062744_ChIP-ChIP_HESCs_Human0.83664884
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83175960
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82463533
131* CHD1_26751641_Chip-Seq_LNCaP_Human0.82212893
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81314168
133ATF3_27146783_Chip-Seq_COLON_Human0.77585016
134TCF3_18692474_ChIP-Seq_MESCs_Mouse0.75931786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.65549116
2MP0010094_abnormal_chromosome_stability4.18875378
3MP0004957_abnormal_blastocyst_morpholog4.18361616
4MP0003111_abnormal_nucleus_morphology3.57749359
5MP0003077_abnormal_cell_cycle3.57711604
6MP0010352_gastrointestinal_tract_polyps3.32030884
7MP0008057_abnormal_DNA_replication2.97167062
8MP0003123_paternal_imprinting2.77909885
9MP0008007_abnormal_cellular_replicative2.46704539
10MP0008058_abnormal_DNA_repair2.35446978
11MP0002396_abnormal_hematopoietic_system2.30531373
12MP0001730_embryonic_growth_arrest2.28498476
13MP0003941_abnormal_skin_development2.27076659
14MP0000350_abnormal_cell_proliferation2.24839806
15MP0008877_abnormal_DNA_methylation2.23126311
16MP0003718_maternal_effect2.22249583
17MP0008932_abnormal_embryonic_tissue2.20149198
18MP0010307_abnormal_tumor_latency2.14657841
19MP0004808_abnormal_hematopoietic_stem1.98361837
20MP0002009_preneoplasia1.96750982
21MP0010234_abnormal_vibrissa_follicle1.93654870
22MP0000490_abnormal_crypts_of1.87709113
23MP0003303_peritoneal_inflammation1.77190911
24MP0001672_abnormal_embryogenesis/_devel1.72367572
25MP0005380_embryogenesis_phenotype1.72367572
26MP0001697_abnormal_embryo_size1.72298461
27MP0004185_abnormal_adipocyte_glucose1.71479531
28MP0002796_impaired_skin_barrier1.67726715
29MP0002084_abnormal_developmental_patter1.62199111
30MP0003705_abnormal_hypodermis_morpholog1.61366942
31MP0002086_abnormal_extraembryonic_tissu1.60182049
32MP0005076_abnormal_cell_differentiation1.58564280
33MP0001545_abnormal_hematopoietic_system1.54547601
34MP0005397_hematopoietic_system_phenotyp1.54547601
35MP0002019_abnormal_tumor_incidence1.54086768
36MP0003121_genomic_imprinting1.53370571
37MP0005623_abnormal_meninges_morphology1.52972519
38MP0002080_prenatal_lethality1.49580166
39MP0003984_embryonic_growth_retardation1.48309723
40MP0002085_abnormal_embryonic_tissue1.47965506
41MP0002088_abnormal_embryonic_growth/wei1.45272783
42MP0005023_abnormal_wound_healing1.43463903
43MP0005451_abnormal_body_composition1.43068876
44MP0006054_spinal_hemorrhage1.41811961
45MP0003890_abnormal_embryonic-extraembry1.40392516
46MP0003763_abnormal_thymus_physiology1.40172624
47MP0003786_premature_aging1.32651698
48MP0004197_abnormal_fetal_growth/weight/1.31609886
49MP0003221_abnormal_cardiomyocyte_apopto1.29774914
50MP0000313_abnormal_cell_death1.28412830
51MP0001915_intracranial_hemorrhage1.23121783
52MP0002877_abnormal_melanocyte_morpholog1.22384025
53MP0000703_abnormal_thymus_morphology1.21616537
54MP0002398_abnormal_bone_marrow1.20305865
55MP0003300_gastrointestinal_ulcer1.18532305
56MP0003566_abnormal_cell_adhesion1.18032554
57MP0004947_skin_inflammation1.17688942
58MP0001119_abnormal_female_reproductive1.15707790
59MP0005501_abnormal_skin_physiology1.14418873
60MP0000858_altered_metastatic_potential1.14203402
61MP0002060_abnormal_skin_morphology1.13872554
62MP0009333_abnormal_splenocyte_physiolog1.13794181
63MP0000537_abnormal_urethra_morphology1.13696237
64MP0001216_abnormal_epidermal_layer1.13563772
65MP0002210_abnormal_sex_determination1.13202583
66MP0004272_abnormal_basement_membrane1.11616687
67MP0002006_tumorigenesis1.09634023
68MP0003567_abnormal_fetal_cardiomyocyte1.09599971
69MP0004264_abnormal_extraembryonic_tissu1.09080349
70MP0002722_abnormal_immune_system1.08806125
71MP0000689_abnormal_spleen_morphology1.07419854
72MP0001929_abnormal_gametogenesis1.05679707
73MP0001835_abnormal_antigen_presentation1.03718314
74MP0000653_abnormal_sex_gland1.00871835
75MP0001919_abnormal_reproductive_system0.99540137
76MP0009278_abnormal_bone_marrow0.99215483
77MP0008438_abnormal_cutaneous_collagen0.98185391
78MP0001293_anophthalmia0.97867337
79MP0001145_abnormal_male_reproductive0.97757562
80MP0004233_abnormal_muscle_weight0.96863685
81MP0001243_abnormal_dermal_layer0.95554329
82MP0000569_abnormal_digit_pigmentation0.95282340
83MP0002092_abnormal_eye_morphology0.94843128
84MP0000465_gastrointestinal_hemorrhage0.94344468
85MP0009053_abnormal_anal_canal0.94126922
86MP0003806_abnormal_nucleotide_metabolis0.93611567
87MP0005621_abnormal_cell_physiology0.90696122
88MP0003699_abnormal_female_reproductive0.90129792
89MP0003448_altered_tumor_morphology0.89157033
90MP0005389_reproductive_system_phenotype0.88936170
91MP0003453_abnormal_keratinocyte_physiol0.88424851
92MP0001849_ear_inflammation0.87395155
93MP0009703_decreased_birth_body0.87238605
94MP0008260_abnormal_autophagy0.87122692
95MP0002429_abnormal_blood_cell0.86473168
96MP0000477_abnormal_intestine_morphology0.86275395
97MP0005395_other_phenotype0.86090984
98MP0005058_abnormal_lysosome_morphology0.85863105
99MP0006292_abnormal_olfactory_placode0.84778339
100MP0002148_abnormal_hypersensitivity_rea0.84142873
101MP0002254_reproductive_system_inflammat0.83869624
102MP0002998_abnormal_bone_remodeling0.83516472
103MP0005384_cellular_phenotype0.82165674
104MP0002697_abnormal_eye_size0.82053221
105MP0002419_abnormal_innate_immunity0.82004995
106MP0003436_decreased_susceptibility_to0.81655714
107MP0010155_abnormal_intestine_physiology0.80650512
108MP0002166_altered_tumor_susceptibility0.80215638
109MP0000716_abnormal_immune_system0.79953729
110MP0009785_altered_susceptibility_to0.79848045
111MP0005000_abnormal_immune_tolerance0.79331651
112MP0010678_abnormal_skin_adnexa0.78466329
113MP0003315_abnormal_perineum_morphology0.77498255
114MP0003656_abnormal_erythrocyte_physiolo0.76849247
115MP0001853_heart_inflammation0.75838667
116MP0000428_abnormal_craniofacial_morphol0.75511821
117MP0010030_abnormal_orbit_morphology0.75405799
118MP0005408_hypopigmentation0.75365815
119MP0004782_abnormal_surfactant_physiolog0.74697229
120MP0001873_stomach_inflammation0.74454018
121MP0000627_abnormal_mammary_gland0.73725253
122MP0002282_abnormal_trachea_morphology0.71348256
123MP0002405_respiratory_system_inflammati0.71303786
124MP0003937_abnormal_limbs/digits/tail_de0.70068631
125MP0001800_abnormal_humoral_immune0.69029750
126MP0003119_abnormal_digestive_system0.67964433
127MP0003091_abnormal_cell_migration0.67420423
128MP0002111_abnormal_tail_morphology0.66379929
129MP0009697_abnormal_copulation0.66335423
130MP0002420_abnormal_adaptive_immunity0.65774666
131MP0001819_abnormal_immune_cell0.63878530
132MP0002452_abnormal_antigen_presenting0.63330732
133MP0009672_abnormal_birth_weight0.60192590

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.32781640
2Colon cancer (HP:0003003)3.73133276
3Agnosia (HP:0010524)3.30877276
4Chromsome breakage (HP:0040012)3.26888872
5Breast hypoplasia (HP:0003187)3.25283533
6Rhabdomyosarcoma (HP:0002859)3.25009358
7Selective tooth agenesis (HP:0001592)3.23791356
8Abnormality of chromosome stability (HP:0003220)3.11817828
9Degeneration of anterior horn cells (HP:0002398)3.07991292
10Abnormality of the anterior horn cell (HP:0006802)3.07991292
11Ependymoma (HP:0002888)3.03140883
12Myelodysplasia (HP:0002863)2.95854724
13Medulloblastoma (HP:0002885)2.93878098
14Reticulocytopenia (HP:0001896)2.88776463
15Osteolytic defects of the phalanges of the hand (HP:0009771)2.86699983
16Osteolytic defects of the hand bones (HP:0009699)2.86699983
17Thrombocytosis (HP:0001894)2.84788688
18Basal cell carcinoma (HP:0002671)2.83226097
19Abnormality of oral frenula (HP:0000190)2.80627394
20Abnormality of the labia minora (HP:0012880)2.78220562
21Spinal cord lesions (HP:0100561)2.76528322
22Syringomyelia (HP:0003396)2.76528322
23Ankyloglossia (HP:0010296)2.70229286
24T lymphocytopenia (HP:0005403)2.70156635
25Biliary tract neoplasm (HP:0100574)2.67119787
26Oral leukoplakia (HP:0002745)2.61896795
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.58912417
28Deep philtrum (HP:0002002)2.55964258
29Abnormality of the preputium (HP:0100587)2.52384327
30Acute myeloid leukemia (HP:0004808)2.51538624
31Deviation of the thumb (HP:0009603)2.49320555
32Aplastic anemia (HP:0001915)2.49093496
33Premature rupture of membranes (HP:0001788)2.47842522
34Premature ovarian failure (HP:0008209)2.45934463
35Progressive external ophthalmoplegia (HP:0000590)2.43729612
36Volvulus (HP:0002580)2.43504571
37Meckel diverticulum (HP:0002245)2.42925415
38Duodenal stenosis (HP:0100867)2.42834550
39Small intestinal stenosis (HP:0012848)2.42834550
40Short middle phalanx of the 5th finger (HP:0004220)2.41211641
41Nephroblastoma (Wilms tumor) (HP:0002667)2.40657809
42Patellar aplasia (HP:0006443)2.38866668
43Atrophy/Degeneration involving motor neurons (HP:0007373)2.35939150
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.35875940
45Chronic bronchitis (HP:0004469)2.35645421
46Amaurosis fugax (HP:0100576)2.33553346
47Absent thumb (HP:0009777)2.32073138
48Microretrognathia (HP:0000308)2.31501174
49Proximal placement of thumb (HP:0009623)2.31409754
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.29015788
51Ankle contracture (HP:0006466)2.28682157
52Abnormality of the ileum (HP:0001549)2.24253325
53Carpal bone hypoplasia (HP:0001498)2.23146408
54Facial hemangioma (HP:0000329)2.22976368
55Embryonal renal neoplasm (HP:0011794)2.21602761
56Abnormality of T cell number (HP:0011839)2.20888654
57Short nail (HP:0001799)2.20381231
58Aplasia/Hypoplasia of the patella (HP:0006498)2.20193409
59Neoplasm of striated muscle (HP:0009728)2.18392145
60Neoplasm of the pancreas (HP:0002894)2.17864508
61Astrocytoma (HP:0009592)2.17331169
62Abnormality of the astrocytes (HP:0100707)2.17331169
63Sloping forehead (HP:0000340)2.16449627
64Neoplasm of the oral cavity (HP:0100649)2.11789818
65Increased nuchal translucency (HP:0010880)2.11473979
66Termporal pattern (HP:0011008)2.11246451
67Insidious onset (HP:0003587)2.11246451
68Neoplasm of the colon (HP:0100273)2.10428947
69Impulsivity (HP:0100710)2.08947087
70Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.08310255
71Malignant gastrointestinal tract tumors (HP:0006749)2.07796553
72Gastrointestinal carcinoma (HP:0002672)2.07796553
73Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.07719701
74Eczematoid dermatitis (HP:0000976)2.07443474
75Glossoptosis (HP:0000162)2.06954531
76Abnormality of cells of the erythroid lineage (HP:0012130)2.05851054
77Increased density of long bones (HP:0006392)2.03908221
7811 pairs of ribs (HP:0000878)2.03666609
79Cortical dysplasia (HP:0002539)2.03057442
80Hyperacusis (HP:0010780)2.02769507
81Rough bone trabeculation (HP:0100670)2.00636252
82Supernumerary spleens (HP:0009799)2.00549207
83Abnormality of the musculature of the pelvis (HP:0001469)2.00347154
84Abnormality of the hip-girdle musculature (HP:0001445)2.00347154
85Premature loss of primary teeth (HP:0006323)1.97620745
86Flat acetabular roof (HP:0003180)1.97527730
87Prominent nose (HP:0000448)1.96636285
88Orthostatic hypotension (HP:0001278)1.96077245
89Multiple enchondromatosis (HP:0005701)1.95852193
90Cafe-au-lait spot (HP:0000957)1.95746550
91Abnormality of the duodenum (HP:0002246)1.94371993
92High pitched voice (HP:0001620)1.94095854
93Flared metaphyses (HP:0003015)1.93232838
94Insomnia (HP:0100785)1.92777256
95Blepharitis (HP:0000498)1.92271836
96Leiomyosarcoma (HP:0100243)1.90998152
97Uterine leiomyosarcoma (HP:0002891)1.90998152
98Missing ribs (HP:0000921)1.90018722
99Resting tremor (HP:0002322)1.88984242
100Sandal gap (HP:0001852)1.88869468
101Spastic diplegia (HP:0001264)1.87909404
102Recurrent viral infections (HP:0004429)1.87317359
103Protrusio acetabuli (HP:0003179)1.87164767
104Abnormal number of erythroid precursors (HP:0012131)1.86861529
105Subacute progressive viral hepatitis (HP:0006572)1.85801893
106Arterial tortuosity (HP:0005116)1.85324198
107Recurrent bacterial skin infections (HP:0005406)1.84232818
108Absent radius (HP:0003974)1.84027396
109Clubbing of toes (HP:0100760)1.82942901
110Glioma (HP:0009733)1.82816060
111Natal tooth (HP:0000695)1.82544318
112Atresia of the external auditory canal (HP:0000413)1.81932147
113Cerebral inclusion bodies (HP:0100314)1.81806370
114Long palpebral fissure (HP:0000637)1.81691696
115Ectopic kidney (HP:0000086)1.81348178
116Secondary amenorrhea (HP:0000869)1.80308452
117Vertebral compression fractures (HP:0002953)1.79814520
118Spinal muscular atrophy (HP:0007269)1.78880229
119Abnormality of the distal phalanx of the thumb (HP:0009617)1.78624688
120Abnormal biliary tract morphology (HP:0012440)1.78503227
121Pulmonary fibrosis (HP:0002206)1.77475477
122Neoplasm of the small intestine (HP:0100833)1.76428597
123Bone marrow hypocellularity (HP:0005528)1.76383278
124Pelvic girdle muscle weakness (HP:0003749)1.76363097
125Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76308622
126Aplasia/hypoplasia of the humerus (HP:0006507)1.76061238
127Upper motor neuron abnormality (HP:0002127)1.75744715
128Uterine neoplasm (HP:0010784)1.74347677
129Squamous cell carcinoma (HP:0002860)1.74259693
130Skull defect (HP:0001362)1.74015281
131Aplasia cutis congenita (HP:0001057)1.73940192
132Ovarian neoplasm (HP:0100615)1.73706099
133Premature graying of hair (HP:0002216)1.73607461
134Freckling (HP:0001480)1.72875872
135Arnold-Chiari malformation (HP:0002308)1.72865809
136Abnormality of the carotid arteries (HP:0005344)1.72669935
137Absent frontal sinuses (HP:0002688)1.71610808
138Amyotrophic lateral sclerosis (HP:0007354)1.70659427
139Persistence of primary teeth (HP:0006335)1.70448842
140Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70369809
141Short 4th metacarpal (HP:0010044)1.70369809
142Abnormality of the salivary glands (HP:0010286)1.70171417
143Hepatosplenomegaly (HP:0001433)1.70029178
144Abnormal lung lobation (HP:0002101)1.69914869
145Overlapping toe (HP:0001845)1.69564163
146Abnormality of the distal phalanges of the toes (HP:0010182)1.68806971
147Disinhibition (HP:0000734)1.68778530
148Neoplasm of the rectum (HP:0100743)1.68746020
149Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68171595
150Short humerus (HP:0005792)1.68020326
151Abnormal foot bone ossification (HP:0010675)1.67415322
152Transitional cell carcinoma of the bladder (HP:0006740)1.66147806
153Combined immunodeficiency (HP:0005387)1.65635606
154Pseudobulbar signs (HP:0002200)1.63100505
155Tetraparesis (HP:0002273)1.62823673
156Recurrent abscess formation (HP:0002722)1.61234058
157Decreased skull ossification (HP:0004331)1.60515525
158Facial cleft (HP:0002006)1.60485681
159Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.60338173
160Capillary hemangiomas (HP:0005306)1.60226127
161Bladder carcinoma (HP:0002862)1.58946611
162Bladder neoplasm (HP:0009725)1.58946611
163Periodontitis (HP:0000704)1.56804609
164Dilatation of the ascending aorta (HP:0005111)1.56682030
165Trismus (HP:0000211)1.56662030
166Metaphyseal cupping (HP:0003021)1.55247596
167Interstitial pulmonary disease (HP:0006530)1.54155530
168Relative macrocephaly (HP:0004482)1.53641672
169Abnormality of the calcaneus (HP:0008364)1.53454339
170Delayed cranial suture closure (HP:0000270)1.53213066
171Vascular tortuosity (HP:0004948)1.52749610
172Cellulitis (HP:0100658)1.52254093
173Apathy (HP:0000741)1.51448350
174Micronodular cirrhosis (HP:0001413)1.51384751
175Abnormality of the thoracic spine (HP:0100711)1.49923912
176Ulnar bowing (HP:0003031)1.49839205
177Vertebral arch anomaly (HP:0008438)1.49616538
178Microvesicular hepatic steatosis (HP:0001414)1.49216747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.61088883
2WEE13.71501758
3BUB13.06443432
4TTK2.89774273
5SMG12.77677047
6EIF2AK12.64983898
7STK102.59950767
8EEF2K2.54882072
9NEK22.53921605
10RPS6KA42.30719568
11IRAK32.25802563
12EPHA22.25134814
13RPS6KB22.10408070
14BRSK22.10084436
15SCYL22.01475856
16MAP3K81.99258039
17NEK11.98511171
18ACVR1B1.89578610
19CDK121.87397761
20TSSK61.84925927
21PLK11.82633093
22PRPF4B1.79403763
23PLK41.77109787
24MAP3K141.75837622
25STK241.73421506
26AURKB1.59438738
27BRD41.52392391
28PDGFRA1.52094928
29SRPK11.51372829
30PLK31.48688219
31CDK71.47520756
32CHEK21.42828463
33ATR1.42638913
34PKN21.41779064
35PASK1.40811798
36LRRK21.40275538
37TAF11.38758504
38PBK1.35806914
39LATS21.35175783
40CLK11.25891033
41MKNK11.25321405
42FGR1.25016510
43STK31.24564150
44EIF2AK31.24340714
45TGFBR11.24189474
46CDK41.24188107
47TESK21.22854321
48BCR1.22635019
49MAP3K61.22369985
50NEK91.20373813
51PAK41.19763577
52CDK61.16879541
53DYRK31.15743682
54LATS11.15439594
55VRK11.08877717
56CHEK11.08695025
57NME21.07517860
58RIPK11.04713298
59MST41.01755285
60MST1R1.01143024
61MAPKAPK30.97526175
62TRIB30.96474907
63STK160.96204461
64ALK0.94850711
65BRAF0.92814989
66AURKA0.92175857
67MELK0.90424294
68ERBB40.90084538
69ATM0.87914661
70CSK0.86850186
71NTRK10.85270144
72BRSK10.83659041
73TESK10.82554691
74PIM10.82416018
75JAK30.82402966
76IRAK40.81256067
77IRAK20.78015971
78MAP3K100.77695412
79RAF10.75342236
80MAP4K10.74951145
81CDK20.74753547
82ICK0.73105115
83FLT30.72416543
84FGFR40.71928693
85MET0.71458986
86MOS0.69849577
87TGFBR20.69661651
88YES10.69367013
89TLK10.68287903
90STK40.68135016
91STK38L0.64497859
92BMPR20.62891856
93GRK60.61923865
94PDGFRB0.60548276
95CDK80.60538523
96ZAP700.58505115
97MAP3K130.58225388
98MATK0.57738178
99MAP3K50.56870937
100SIK30.55944322
101MAP3K90.55045459
102KSR20.53792766
103TAOK20.52401090
104MKNK20.50299929
105BTK0.49698275
106JAK10.49110653
107CDK10.49079314
108MAP2K30.48999012
109TEC0.48354784
110ZAK0.48280470
111CDK140.47057538
112CSNK2A20.46668549
113PDK40.44609944
114PDK30.44609944
115PAK10.44414190
116BMX0.43882830
117RIPK40.42500055
118CDK180.41802794
119PTK60.40672829
120CDK150.39073209
121PAK20.38968922
122VRK20.38609523
123KDR0.38398115
124CDK11A0.38344680
125TYK20.38308461
126CSNK2A10.37489074
127CDK90.37082004
128PNCK0.36460691
129FGFR10.35476867
130TAOK10.35088242
131ERBB30.34473228
132MTOR0.34085007
133CSNK1E0.33562716
134MAP3K30.28999058
135KSR10.28459488
136EIF2AK20.27563144
137CHUK0.25382034
138PRKDC0.23074647
139TRPM70.22087305
140CSNK1D0.22022773

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.39519250
2Mismatch repair_Homo sapiens_hsa034303.80756182
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.62326804
4RNA transport_Homo sapiens_hsa030133.20250842
5Cell cycle_Homo sapiens_hsa041103.05320902
6Spliceosome_Homo sapiens_hsa030402.58813711
7One carbon pool by folate_Homo sapiens_hsa006702.49629253
8Homologous recombination_Homo sapiens_hsa034402.49545722
9Base excision repair_Homo sapiens_hsa034102.49207702
10Nucleotide excision repair_Homo sapiens_hsa034202.43550831
11RNA degradation_Homo sapiens_hsa030182.34847579
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28007332
13Ribosome_Homo sapiens_hsa030102.22621569
14RNA polymerase_Homo sapiens_hsa030202.04242971
15Fanconi anemia pathway_Homo sapiens_hsa034602.02855737
16Non-homologous end-joining_Homo sapiens_hsa034501.99118440
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92856899
18Proteasome_Homo sapiens_hsa030501.90172446
19p53 signaling pathway_Homo sapiens_hsa041151.86421858
20Pyrimidine metabolism_Homo sapiens_hsa002401.76937026
21mRNA surveillance pathway_Homo sapiens_hsa030151.75793183
22Basal transcription factors_Homo sapiens_hsa030221.70889605
23Viral carcinogenesis_Homo sapiens_hsa052031.35487420
24Antigen processing and presentation_Homo sapiens_hsa046121.34186455
25Systemic lupus erythematosus_Homo sapiens_hsa053221.32817715
26Oocyte meiosis_Homo sapiens_hsa041141.30031471
27Thyroid cancer_Homo sapiens_hsa052161.26181331
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24657316
29Epstein-Barr virus infection_Homo sapiens_hsa051691.23202867
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21407995
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19008392
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18294759
33MicroRNAs in cancer_Homo sapiens_hsa052061.12236153
34Small cell lung cancer_Homo sapiens_hsa052221.10945010
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09515007
36Herpes simplex infection_Homo sapiens_hsa051681.07610215
37HTLV-I infection_Homo sapiens_hsa051661.06373555
38Shigellosis_Homo sapiens_hsa051311.03293777
39Colorectal cancer_Homo sapiens_hsa052100.99616031
40Renal cell carcinoma_Homo sapiens_hsa052110.97891569
41TGF-beta signaling pathway_Homo sapiens_hsa043500.93104054
42Hepatitis C_Homo sapiens_hsa051600.89200027
43Chronic myeloid leukemia_Homo sapiens_hsa052200.88456086
44Selenocompound metabolism_Homo sapiens_hsa004500.87019232
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86511791
46Legionellosis_Homo sapiens_hsa051340.83923112
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.80970746
48Hepatitis B_Homo sapiens_hsa051610.80669260
49Pancreatic cancer_Homo sapiens_hsa052120.79711024
50mTOR signaling pathway_Homo sapiens_hsa041500.79583745
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79092745
52* Purine metabolism_Homo sapiens_hsa002300.78905620
53Amoebiasis_Homo sapiens_hsa051460.75835973
54Malaria_Homo sapiens_hsa051440.74004341
55Other glycan degradation_Homo sapiens_hsa005110.71542446
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70711474
57Adherens junction_Homo sapiens_hsa045200.70477366
58Apoptosis_Homo sapiens_hsa042100.70059890
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68088338
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.67800532
61Pentose phosphate pathway_Homo sapiens_hsa000300.66202868
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.66109833
63Measles_Homo sapiens_hsa051620.65546389
64Bladder cancer_Homo sapiens_hsa052190.64672387
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.63669967
66Hippo signaling pathway_Homo sapiens_hsa043900.62358749
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62125038
68Tuberculosis_Homo sapiens_hsa051520.60925863
69Biosynthesis of amino acids_Homo sapiens_hsa012300.58893434
70Glioma_Homo sapiens_hsa052140.58569176
71Acute myeloid leukemia_Homo sapiens_hsa052210.57435058
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57374543
73Focal adhesion_Homo sapiens_hsa045100.56329049
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55841633
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55585482
76Leishmaniasis_Homo sapiens_hsa051400.54138077
77Toxoplasmosis_Homo sapiens_hsa051450.54132080
78Notch signaling pathway_Homo sapiens_hsa043300.53522208
79Influenza A_Homo sapiens_hsa051640.52429341
80Viral myocarditis_Homo sapiens_hsa054160.52312414
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.51693431
82ErbB signaling pathway_Homo sapiens_hsa040120.51573707
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.51468562
84HIF-1 signaling pathway_Homo sapiens_hsa040660.51248110
85Non-small cell lung cancer_Homo sapiens_hsa052230.50543438
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50321542
87Prion diseases_Homo sapiens_hsa050200.49356896
88Primary immunodeficiency_Homo sapiens_hsa053400.49133903
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47710459
90Chemokine signaling pathway_Homo sapiens_hsa040620.47621329
91Proteoglycans in cancer_Homo sapiens_hsa052050.47482376
92TNF signaling pathway_Homo sapiens_hsa046680.45821942
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44067375
94Prostate cancer_Homo sapiens_hsa052150.43770595
95Alcoholism_Homo sapiens_hsa050340.43180167
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42736231
97B cell receptor signaling pathway_Homo sapiens_hsa046620.41884098
98Pathways in cancer_Homo sapiens_hsa052000.39849017
99Endometrial cancer_Homo sapiens_hsa052130.39084858
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.38950956
101VEGF signaling pathway_Homo sapiens_hsa043700.38754155
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37549317
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37455342
104Hematopoietic cell lineage_Homo sapiens_hsa046400.37341286
105T cell receptor signaling pathway_Homo sapiens_hsa046600.37338296
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35732764
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.34331730
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.32424916
109Folate biosynthesis_Homo sapiens_hsa007900.32356427
110Glutathione metabolism_Homo sapiens_hsa004800.31957490
111FoxO signaling pathway_Homo sapiens_hsa040680.31179559
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31112879
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30355527
114Platelet activation_Homo sapiens_hsa046110.29893813
115Salmonella infection_Homo sapiens_hsa051320.28656835
116N-Glycan biosynthesis_Homo sapiens_hsa005100.28440783
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26456804
118Prolactin signaling pathway_Homo sapiens_hsa049170.26146626
119Osteoclast differentiation_Homo sapiens_hsa043800.24646505

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