ADTRP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.52948163
2L-phenylalanine catabolic process (GO:0006559)7.52948163
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.16304413
4L-phenylalanine metabolic process (GO:0006558)7.16304413
5aromatic amino acid family catabolic process (GO:0009074)6.81668078
6angiotensin maturation (GO:0002003)6.66268452
7regulation of guanylate cyclase activity (GO:0031282)6.43250506
8tryptophan catabolic process (GO:0006569)6.18440270
9indole-containing compound catabolic process (GO:0042436)6.18440270
10indolalkylamine catabolic process (GO:0046218)6.18440270
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.02575871
12kynurenine metabolic process (GO:0070189)5.92661559
13bile acid biosynthetic process (GO:0006699)5.83011800
14glyoxylate metabolic process (GO:0046487)5.80569125
15tryptophan metabolic process (GO:0006568)5.80241669
16cysteine metabolic process (GO:0006534)5.47908595
17urea metabolic process (GO:0019627)5.39819292
18urea cycle (GO:0000050)5.39819292
19high-density lipoprotein particle remodeling (GO:0034375)5.26231997
20alpha-linolenic acid metabolic process (GO:0036109)5.24075903
21sulfur amino acid catabolic process (GO:0000098)5.22722870
22serine family amino acid catabolic process (GO:0009071)5.20455569
23regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.19637762
24positive regulation of guanylate cyclase activity (GO:0031284)5.12885666
25negative regulation of fibrinolysis (GO:0051918)5.08988263
26protein carboxylation (GO:0018214)5.06080593
27peptidyl-glutamic acid carboxylation (GO:0017187)5.06080593
28regulation of fibrinolysis (GO:0051917)5.03339766
29bile acid metabolic process (GO:0008206)5.01646112
30aromatic amino acid family metabolic process (GO:0009072)5.00330010
31nitrogen cycle metabolic process (GO:0071941)4.99547136
32complement activation, alternative pathway (GO:0006957)4.95544638
33regulation of protein activation cascade (GO:2000257)4.92094386
34homocysteine metabolic process (GO:0050667)4.87135980
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86043371
36regulation of triglyceride catabolic process (GO:0010896)4.83440542
37intestinal absorption (GO:0050892)4.79913658
38amino-acid betaine metabolic process (GO:0006577)4.73351689
39tyrosine metabolic process (GO:0006570)4.69787688
40regulation of cholesterol esterification (GO:0010872)4.68813559
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.68246320
42cellular ketone body metabolic process (GO:0046950)4.62947556
43lysine metabolic process (GO:0006553)4.60941625
44lysine catabolic process (GO:0006554)4.60941625
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.60506094
46alpha-amino acid catabolic process (GO:1901606)4.60334019
47regulation of complement activation (GO:0030449)4.59416984
48triglyceride homeostasis (GO:0070328)4.54484822
49acylglycerol homeostasis (GO:0055090)4.54484822
50reverse cholesterol transport (GO:0043691)4.53089200
51protein-lipid complex remodeling (GO:0034368)4.50494570
52macromolecular complex remodeling (GO:0034367)4.50494570
53plasma lipoprotein particle remodeling (GO:0034369)4.50494570
54regulation of cellular extravasation (GO:0002691)4.45747622
55indolalkylamine metabolic process (GO:0006586)4.43802355
56phospholipid efflux (GO:0033700)4.42334926
57negative regulation of sterol transport (GO:0032372)4.40576143
58negative regulation of cholesterol transport (GO:0032375)4.40576143
59positive regulation of respiratory burst (GO:0060267)4.40143388
60bile acid and bile salt transport (GO:0015721)4.38331375
61amine catabolic process (GO:0009310)4.34221139
62cellular biogenic amine catabolic process (GO:0042402)4.34221139
63coenzyme catabolic process (GO:0009109)4.34019654
64glycine metabolic process (GO:0006544)4.33991437
65fat-soluble vitamin biosynthetic process (GO:0042362)4.29875610
66serine family amino acid metabolic process (GO:0009069)4.28759511
67antigen processing and presentation of endogenous antigen (GO:0019883)4.26692369
68cellular amino acid catabolic process (GO:0009063)4.26498959
69cellular glucuronidation (GO:0052695)4.21753416
70drug catabolic process (GO:0042737)4.20355881
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.17753262
72plasma lipoprotein particle clearance (GO:0034381)4.15244436
73glutamate metabolic process (GO:0006536)4.14774439
74imidazole-containing compound metabolic process (GO:0052803)4.11056183
75benzene-containing compound metabolic process (GO:0042537)4.09917211
76regulation of vitamin metabolic process (GO:0030656)4.08004231
77serine family amino acid biosynthetic process (GO:0009070)4.07833419
78cholesterol efflux (GO:0033344)4.02812908
79ketone body metabolic process (GO:1902224)4.00977069
80cellular modified amino acid catabolic process (GO:0042219)3.95514411
81short-chain fatty acid metabolic process (GO:0046459)3.95083553
82regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.93798616
83endocrine process (GO:0050886)3.93798616
84regulation of systemic arterial blood pressure by hormone (GO:0001990)3.93798616
85ethanol oxidation (GO:0006069)3.93564001
86regulation of bile acid biosynthetic process (GO:0070857)3.90783653
87negative regulation of lipase activity (GO:0060192)3.89941952
88fibrinolysis (GO:0042730)3.89522769
89aldehyde catabolic process (GO:0046185)3.89181687
90arginine metabolic process (GO:0006525)3.88653858
91vitamin A metabolic process (GO:0006776)3.87059517
92glucuronate metabolic process (GO:0019585)3.83076815
93uronic acid metabolic process (GO:0006063)3.83076815
94epoxygenase P450 pathway (GO:0019373)3.81436449
95acetyl-CoA metabolic process (GO:0006084)3.81179025
96organic acid catabolic process (GO:0016054)3.80210211
97carboxylic acid catabolic process (GO:0046395)3.80210211
98drug transmembrane transport (GO:0006855)3.75334335
99urate metabolic process (GO:0046415)3.74940995
100positive regulation of lipoprotein lipase activity (GO:0051006)3.74384549
101positive regulation of triglyceride lipase activity (GO:0061365)3.74384549
102plasma lipoprotein particle assembly (GO:0034377)3.74210174
103low-density lipoprotein particle remodeling (GO:0034374)3.71704960
104cholesterol homeostasis (GO:0042632)3.70958217
105blood coagulation, intrinsic pathway (GO:0007597)3.69208472
106cofactor catabolic process (GO:0051187)3.69182369
107exogenous drug catabolic process (GO:0042738)3.68080902
108dicarboxylic acid biosynthetic process (GO:0043650)3.67080820
109sterol homeostasis (GO:0055092)3.65418429
110very-low-density lipoprotein particle assembly (GO:0034379)3.65048509
111regulation of cGMP biosynthetic process (GO:0030826)3.64939729
112lipoprotein transport (GO:0042953)3.63373677
113eosinophil chemotaxis (GO:0048245)3.62764812
114regulation of cholesterol homeostasis (GO:2000188)3.60461134
115positive regulation of lipid catabolic process (GO:0050996)3.59064173
116antibacterial humoral response (GO:0019731)3.57724885
117sulfate transmembrane transport (GO:1902358)3.57211308
118antimicrobial humoral response (GO:0019730)3.57080377
119positive regulation of pseudopodium assembly (GO:0031274)3.56820373
120flavonoid metabolic process (GO:0009812)3.55643764
121very long-chain fatty acid metabolic process (GO:0000038)3.55600986
122monocarboxylic acid catabolic process (GO:0072329)3.53776906
123fatty acid oxidation (GO:0019395)3.53260833
124renal system process involved in regulation of blood volume (GO:0001977)3.52294145
125antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51881283
126carnitine metabolic process (GO:0009437)3.51192197
127aspartate family amino acid catabolic process (GO:0009068)3.50675447
128desmosome organization (GO:0002934)3.43988759
129peptide catabolic process (GO:0043171)3.40901676
130regulation of systemic arterial blood pressure (GO:0003073)3.40371507
131positive regulation of glycoprotein biosynthetic process (GO:0010560)3.40363879
132regulation of cGMP metabolic process (GO:0030823)3.39244011
133hormone catabolic process (GO:0042447)3.29279032
134NADH metabolic process (GO:0006734)3.25222676
135eosinophil migration (GO:0072677)3.19541679
136regulation of antigen processing and presentation (GO:0002577)3.17694018
137adhesion of symbiont to host cell (GO:0044650)3.11937527
138virion attachment to host cell (GO:0019062)3.11937527
139regulation of pseudopodium assembly (GO:0031272)3.11059840
140oligosaccharide biosynthetic process (GO:0009312)3.09649619
141regulation of respiratory burst (GO:0060263)3.05395937
142bundle of His cell to Purkinje myocyte communication (GO:0086069)3.04105306
143receptor guanylyl cyclase signaling pathway (GO:0007168)3.03585216
144positive regulation of glycoprotein metabolic process (GO:1903020)3.02130091
145phosphatidylserine acyl-chain remodeling (GO:0036150)3.00849531
146maintenance of gastrointestinal epithelium (GO:0030277)2.99865873
147L-fucose catabolic process (GO:0042355)2.94201567
148fucose catabolic process (GO:0019317)2.94201567
149L-fucose metabolic process (GO:0042354)2.94201567
150transcytosis (GO:0045056)2.93062494
151peptide hormone processing (GO:0016486)2.92747634
152positive regulation of antigen processing and presentation (GO:0002579)2.92498908
153glomerular filtration (GO:0003094)2.87366413
154cytidine metabolic process (GO:0046087)2.87306139
155cytidine catabolic process (GO:0006216)2.87306139
156cytidine deamination (GO:0009972)2.87306139
157glycosphingolipid catabolic process (GO:0046479)2.87277782
158fructose metabolic process (GO:0006000)2.84422631
159phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.83445636
160drug metabolic process (GO:0017144)2.82992199
161sulfate transport (GO:0008272)2.82891491
162pyrimidine-containing compound transmembrane transport (GO:0072531)2.80725790
163glycolipid catabolic process (GO:0019377)2.79413176
164T cell costimulation (GO:0031295)2.79136741
165regulation of regulatory T cell differentiation (GO:0045589)2.77255331
166regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76615993
167pyrimidine ribonucleoside catabolic process (GO:0046133)2.75918225
168lymphocyte costimulation (GO:0031294)2.75045604
169sulfur compound transport (GO:0072348)2.71044888
170digestion (GO:0007586)2.70922923
171calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.70919364
172positive regulation of cGMP biosynthetic process (GO:0030828)2.69810617
173renal filtration (GO:0097205)2.68466444
174thrombin receptor signaling pathway (GO:0070493)2.64988278
175O-glycan processing (GO:0016266)2.64819878
1763-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.64769329
177purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.64769329
178phosphatidylinositol acyl-chain remodeling (GO:0036149)2.63188658
179digestive system process (GO:0022600)2.61927873
180immunoglobulin mediated immune response (GO:0016064)2.61043330
181fucosylation (GO:0036065)2.55682446
182intermediate filament organization (GO:0045109)2.55415606
183NIK/NF-kappaB signaling (GO:0038061)2.55262992
184glycosylceramide metabolic process (GO:0006677)2.53542558
185regulation of protein glycosylation (GO:0060049)2.53450515
186intestinal epithelial cell development (GO:0060576)2.52766624
187diacylglycerol metabolic process (GO:0046339)2.49982305
188fat-soluble vitamin metabolic process (GO:0006775)2.48241119
189negative regulation of cell killing (GO:0031342)2.47217192
190negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47217192
191regulation of gamma-delta T cell differentiation (GO:0045586)2.46635372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.85692171
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.78058368
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.70521492
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.11212588
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.93307435
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.79751133
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.73238507
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.54418423
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.67463157
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.62831466
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85200767
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.39395742
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37606214
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25503263
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.24708230
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11311961
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09970371
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1517853
19RUNX_20019798_ChIP-Seq_JUKART_Human1.96349134
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96235846
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92988822
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.84226706
23HTT_18923047_ChIP-ChIP_STHdh_Human1.75410871
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69893064
25GATA6_25053715_ChIP-Seq_YYC3_Human1.69356599
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.69276230
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65374471
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55366309
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48215091
30MYB_26560356_Chip-Seq_TH2_Human1.47475711
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.46232778
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38969602
33VDR_24787735_ChIP-Seq_THP-1_Human1.34547575
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.34290358
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32653232
36HNF4A_19822575_ChIP-Seq_HepG2_Human1.32262321
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28269251
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26703473
39CLOCK_20551151_ChIP-Seq_293T_Human1.23013019
40BCL6_27268052_Chip-Seq_Bcells_Human1.22866354
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22784052
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22013088
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.21880900
44MYB_26560356_Chip-Seq_TH1_Human1.20740471
45FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18618649
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17754952
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17743004
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17698677
49TP63_23658742_ChIP-Seq_EP156T_Human1.17596661
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16728077
51NANOG_20526341_ChIP-Seq_ESCs_Human1.16552135
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16072253
53BCOR_27268052_Chip-Seq_Bcells_Human1.15939222
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15199636
55GATA3_26560356_Chip-Seq_TH2_Human1.11940091
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11736805
57GATA2_19941826_ChIP-Seq_K562_Human1.11599303
58KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11585515
59STAT1_20625510_ChIP-Seq_HELA_Human1.10675075
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.08073632
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07961459
62RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07141109
63GATA1_19941826_ChIP-Seq_K562_Human1.05546707
64GATA3_27048872_Chip-Seq_THYMUS_Human1.04911154
65VDR_22108803_ChIP-Seq_LS180_Human1.03159907
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01318178
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98107747
68GATA4_25053715_ChIP-Seq_YYC3_Human0.97463254
69SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97221228
70TAF15_26573619_Chip-Seq_HEK293_Human0.96512029
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96129340
72GATA1_22025678_ChIP-Seq_K562_Human0.95552277
73GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92855161
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92785309
75P300_27268052_Chip-Seq_Bcells_Human0.92133984
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91927888
77TP63_17297297_ChIP-ChIP_HaCaT_Human0.90624022
78PRDM14_20953172_ChIP-Seq_ESCs_Human0.89855166
79TP63_22573176_ChIP-Seq_HFKS_Human0.89676695
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88802665
81ESR2_21235772_ChIP-Seq_MCF-7_Human0.87767892
82SMRT_27268052_Chip-Seq_Bcells_Human0.87435245
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87139841
84KLF5_25053715_ChIP-Seq_YYC3_Human0.86004172
85CJUN_26792858_Chip-Seq_BT549_Human0.85800842
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85792693
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84393210
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83737333
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83538463
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83394159
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.82772242
92FOXH1_21741376_ChIP-Seq_ESCs_Human0.82708375
93SA1_27219007_Chip-Seq_Bcells_Human0.82240395
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81902433
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79538531
96RXR_22108803_ChIP-Seq_LS180_Human0.79516449
97VDR_24763502_ChIP-Seq_THP-1_Human0.79424279
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77026712
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.76432510
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75182276
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75182276
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74454753
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71846461
104ESR1_21235772_ChIP-Seq_MCF-7_Human0.70921095
105RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69893289
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69393193
107STAT1_17558387_ChIP-Seq_HELA_Human0.69331869
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.69075237
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68438303
110CEBPB_22108803_ChIP-Seq_LS180_Human0.67643948
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65990776
112CDX2_20551321_ChIP-Seq_CACO-2_Human0.65147106
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65128726
114BCAT_22108803_ChIP-Seq_LS180_Human0.64816426
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.63634845
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.63619430
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.63591456
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62202158
119CBP_21632823_ChIP-Seq_H3396_Human0.62174188
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.61456349
121MYC_19915707_ChIP-ChIP_AK7_Human0.60337762
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.60248787
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.59993541
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59775272
125CRX_20693478_ChIP-Seq_RETINA_Mouse0.59087249
126AR_20517297_ChIP-Seq_VCAP_Human0.58625136
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.58613217
128ESET_19884257_ChIP-Seq_ESCs_Mouse0.58095314
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.57924109
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.57127615
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.55342713
132ZNF263_19887448_ChIP-Seq_K562_Human0.54961044
133EGR1_19032775_ChIP-ChIP_M12_Human0.54902329
134OCT4_21477851_ChIP-Seq_ESCs_Mouse0.54582278
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.54441762
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.54178100
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.53705984
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.52665287
139RARG_19884340_ChIP-ChIP_MEFs_Mouse0.52640764
140P53_21459846_ChIP-Seq_SAOS-2_Human0.52443402
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.52423269
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.52307208
143CDX2_22108803_ChIP-Seq_LS180_Human0.52114977
144TAF2_19829295_ChIP-Seq_ESCs_Human0.51442406
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.50901427
146SOX2_20726797_ChIP-Seq_SW620_Human0.50493743
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.50460086
148NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.50447696
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49918494
150RARB_24833708_ChIP-Seq_LIVER_Mouse0.49885092
151ESR1_15608294_ChIP-ChIP_MCF-7_Human0.49628741
152RUNX1_27457419_Chip-Seq_LIVER_Mouse0.47718029
153RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.47685514
154NCOR_22424771_ChIP-Seq_293T_Human0.47190121
155GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.47142396
156FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46001825
157FOXH1_21741376_ChIP-Seq_EPCs_Human0.45934505
158PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45449200
159ETV2_25802403_ChIP-Seq_MESCs_Mouse0.44730534
160IRF1_19129219_ChIP-ChIP_H3396_Human0.43903814
161P63_26484246_Chip-Seq_KERATINOCYTES_Human0.43853282
162HNFA_21074721_ChIP-Seq_CACO-2_Human0.42708928
163PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42485187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.18075834
2MP0005360_urolithiasis7.72889607
3MP0005085_abnormal_gallbladder_physiolo6.30218063
4MP0005365_abnormal_bile_salt5.99009837
5MP0008875_abnormal_xenobiotic_pharmacok5.11267055
6MP0003806_abnormal_nucleotide_metabolis3.87241629
7MP0003252_abnormal_bile_duct3.77397956
8MP0010329_abnormal_lipoprotein_level3.40281634
9MP0009840_abnormal_foam_cell3.25157652
10MP0010155_abnormal_intestine_physiology3.17204162
11MP0001873_stomach_inflammation3.03033361
12MP0005332_abnormal_amino_acid2.95511149
13MP0003195_calcinosis2.89026200
14MP0005083_abnormal_biliary_tract2.84687691
15MP0003183_abnormal_peptide_metabolism2.82895414
16MP0001666_abnormal_nutrient_absorption2.67677396
17MP0004019_abnormal_vitamin_homeostasis2.55156135
18MP0003866_abnormal_defecation2.51286404
19MP0004264_abnormal_extraembryonic_tissu2.29667415
20MP0005451_abnormal_body_composition2.20316908
21MP0005671_abnormal_response_to2.13127004
22MP0003191_abnormal_cellular_cholesterol2.11564646
23MP0004147_increased_porphyrin_level2.10323356
24MP0002118_abnormal_lipid_homeostasis2.09038623
25MP0001790_abnormal_immune_system2.08301665
26MP0005387_immune_system_phenotype2.08301665
27MP0000609_abnormal_liver_physiology2.01541904
28MP0002138_abnormal_hepatobiliary_system1.97413570
29MP0001663_abnormal_digestive_system1.90945768
30MP0001835_abnormal_antigen_presentation1.90011312
31MP0003300_gastrointestinal_ulcer1.84734262
32MP0001800_abnormal_humoral_immune1.84508093
33MP0000490_abnormal_crypts_of1.84074659
34MP0003303_peritoneal_inflammation1.82565796
35MP0003868_abnormal_feces_composition1.81916136
36MP0009785_altered_susceptibility_to1.81402130
37MP0003763_abnormal_thymus_physiology1.69405937
38MP0005319_abnormal_enzyme/_coenzyme1.69067280
39MP0001764_abnormal_homeostasis1.66438245
40MP0004947_skin_inflammation1.65491456
41MP0000465_gastrointestinal_hemorrhage1.63203769
42MP0002148_abnormal_hypersensitivity_rea1.59839075
43MP0000685_abnormal_immune_system1.59190313
44MP0005310_abnormal_salivary_gland1.56984138
45MP0003011_delayed_dark_adaptation1.55242043
46MP0009697_abnormal_copulation1.54301767
47MP0005025_abnormal_response_to1.52912180
48MP0005000_abnormal_immune_tolerance1.52245219
49MP0010352_gastrointestinal_tract_polyps1.50995856
50MP0005584_abnormal_enzyme/coenzyme_acti1.49994186
51MP0009333_abnormal_splenocyte_physiolog1.49890163
52MP0001664_abnormal_digestion1.48038023
53MP0001845_abnormal_inflammatory_respons1.47167931
54MP0005381_digestive/alimentary_phenotyp1.46383785
55MP0002452_abnormal_antigen_presenting1.45482178
56MP0002723_abnormal_immune_serum1.43252376
57MP0003436_decreased_susceptibility_to1.41494181
58MP0009643_abnormal_urine_homeostasis1.38416957
59MP0006082_CNS_inflammation1.32010615
60MP0001819_abnormal_immune_cell1.29326515
61MP0002420_abnormal_adaptive_immunity1.28391009
62MP0000477_abnormal_intestine_morphology1.28281919
63MP0001501_abnormal_sleep_pattern1.27836033
64MP0000678_abnormal_parathyroid_gland1.27475666
65MP0003186_abnormal_redox_activity1.17119567
66MP0005647_abnormal_sex_gland1.17058748
67MP0002254_reproductive_system_inflammat1.12028848
68MP0004381_abnormal_hair_follicle1.11775398
69MP0005636_abnormal_mineral_homeostasis1.08823733
70MP0002166_altered_tumor_susceptibility1.06798869
71MP0002796_impaired_skin_barrier1.06279935
72MP0002419_abnormal_innate_immunity1.04644046
73MP0000604_amyloidosis1.01332937
74MP0009764_decreased_sensitivity_to0.99410864
75MP0003656_abnormal_erythrocyte_physiolo0.98785912
76MP0000598_abnormal_liver_morphology0.97888352
77MP0005410_abnormal_fertilization0.96923053
78MP0002876_abnormal_thyroid_physiology0.93876573
79MP0000716_abnormal_immune_system0.93467953
80MP0005174_abnormal_tail_pigmentation0.91622030
81MP0003718_maternal_effect0.90620718
82MP0005408_hypopigmentation0.89803445
83MP0009763_increased_sensitivity_to0.89144208
84MP0002006_tumorigenesis0.88437754
85MP0001188_hyperpigmentation0.85960925
86MP0001533_abnormal_skeleton_physiology0.85346520
87MP0002405_respiratory_system_inflammati0.84135197
88MP0005275_abnormal_skin_tensile0.83950516
89MP0001661_extended_life_span0.83059777
90MP0009642_abnormal_blood_homeostasis0.82490793
91MP0005670_abnormal_white_adipose0.82066954
92MP0003045_fibrosis0.80139981
93MP0006036_abnormal_mitochondrial_physio0.79005432
94MP0000015_abnormal_ear_pigmentation0.78011471
95MP0002971_abnormal_brown_adipose0.77941718
96MP0008469_abnormal_protein_level0.77417672
97MP0004484_altered_response_of0.76590438
98MP0001756_abnormal_urination0.76386621
99MP0005084_abnormal_gallbladder_morpholo0.75985395
100MP0009765_abnormal_xenobiotic_induced0.74382679
101MP0005409_darkened_coat_color0.73900869
102MP0003329_amyloid_beta_deposits0.73580296
103MP0005535_abnormal_body_temperature0.73550084
104MP0005376_homeostasis/metabolism_phenot0.72739061
105MP0002998_abnormal_bone_remodeling0.72460003
106MP0003690_abnormal_glial_cell0.69980400
107MP0000579_abnormal_nail_morphology0.68911640
108MP0000249_abnormal_blood_vessel0.68017413
109MP0002078_abnormal_glucose_homeostasis0.67326925
110MP0003705_abnormal_hypodermis_morpholog0.65083995
111MP0005220_abnormal_exocrine_pancreas0.64722936
112MP0005334_abnormal_fat_pad0.64070692
113MP0005395_other_phenotype0.63381163
114MP0002136_abnormal_kidney_physiology0.58243736
115MP0006035_abnormal_mitochondrial_morpho0.56480307
116MP0002822_catalepsy0.54856180
117MP0005266_abnormal_metabolism0.54199960
118MP0010368_abnormal_lymphatic_system0.53197270
119MP0004043_abnormal_pH_regulation0.51977534
120MP0005448_abnormal_energy_balance0.51561941
121MP0009053_abnormal_anal_canal0.51490895
122MP0000639_abnormal_adrenal_gland0.49971627
123MP0003638_abnormal_response/metabolism_0.49266048
124MP0004130_abnormal_muscle_cell0.47732781
125MP0005666_abnormal_adipose_tissue0.47268121
126MP0000427_abnormal_hair_cycle0.44419875
127MP0005501_abnormal_skin_physiology0.44135783
128MP0000647_abnormal_sebaceous_gland0.43637292
129MP0003453_abnormal_keratinocyte_physiol0.43455384
130MP0000230_abnormal_systemic_arterial0.43247486
131MP0000566_synostosis0.43095411
132MP0001765_abnormal_ion_homeostasis0.42496954
133MP0002060_abnormal_skin_morphology0.42372404
134MP0008874_decreased_physiological_sensi0.41320435
135MP0003724_increased_susceptibility_to0.41212387
136MP0003953_abnormal_hormone_level0.40065998
137MP0004782_abnormal_surfactant_physiolog0.40057775
138MP0002098_abnormal_vibrissa_morphology0.39734835
139MP0008872_abnormal_physiological_respon0.39404403
140MP0009384_cardiac_valve_regurgitation0.38809900
141MP0008873_increased_physiological_sensi0.37803696
142MP0010234_abnormal_vibrissa_follicle0.35842920
143MP0001216_abnormal_epidermal_layer0.35807311
144MP0009379_abnormal_foot_pigmentation0.35321971
145MP0000538_abnormal_urinary_bladder0.32424077
146MP0005248_abnormal_Harderian_gland0.31909007
147MP0002928_abnormal_bile_duct0.31712442
148MP0000377_abnormal_hair_follicle0.30199683
149MP0001243_abnormal_dermal_layer0.29814347
150MP0002837_dystrophic_cardiac_calcinosis0.29550782
151MP0009672_abnormal_birth_weight0.28026891
152MP0009115_abnormal_fat_cell0.27259008
153MP0010678_abnormal_skin_adnexa0.27250311
154MP0005166_decreased_susceptibility_to0.27135374

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.18148727
2Intrahepatic cholestasis (HP:0001406)7.12808341
3Deep venous thrombosis (HP:0002625)6.81404987
4Prolonged partial thromboplastin time (HP:0003645)6.28084625
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.26751326
6Xanthomatosis (HP:0000991)6.22047487
7Hypobetalipoproteinemia (HP:0003563)6.11317190
8Hyperlipoproteinemia (HP:0010980)5.48266475
9Chronic diarrhea (HP:0002028)5.24241376
10Decreased circulating renin level (HP:0003351)5.00658140
11Complement deficiency (HP:0004431)4.87528578
12Hyperactive renin-angiotensin system (HP:0000841)4.84518456
13Hyperglycinemia (HP:0002154)4.76915619
14Hypolipoproteinemia (HP:0010981)4.56937579
15Hyperglycinuria (HP:0003108)4.52275290
16Hyperammonemia (HP:0001987)4.52269944
17Joint hemorrhage (HP:0005261)4.47963092
18Epidermoid cyst (HP:0200040)4.42861953
19Abnormality of serine family amino acid metabolism (HP:0010894)4.41315468
20Abnormality of glycine metabolism (HP:0010895)4.41315468
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.35422994
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.24023864
23Ketosis (HP:0001946)4.22951335
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.22517579
25Abnormality of renin-angiotensin system (HP:0000847)4.20775866
26Metabolic alkalosis (HP:0200114)4.18811594
27Abnormality of sulfur amino acid metabolism (HP:0004339)4.15717352
28Fat malabsorption (HP:0002630)4.09704789
29Abnormality of methionine metabolism (HP:0010901)4.05650946
30Hypoalphalipoproteinemia (HP:0003233)3.98079361
31Abnormality of the common coagulation pathway (HP:0010990)3.93923890
32Ileus (HP:0002595)3.89934846
33Conjugated hyperbilirubinemia (HP:0002908)3.76575207
34Hypoglycemic coma (HP:0001325)3.68533796
35Abnormality of pyrimidine metabolism (HP:0004353)3.56290130
36Abnormality of complement system (HP:0005339)3.51888004
37Abnormality of fatty-acid metabolism (HP:0004359)3.51631590
38Hypercholesterolemia (HP:0003124)3.34139788
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30865618
40Abnormality of the intrinsic pathway (HP:0010989)3.27280148
41Abnormality of serum amino acid levels (HP:0003112)3.24177331
42Eczematoid dermatitis (HP:0000976)3.21910564
43Congenital sensorineural hearing impairment (HP:0008527)3.21118365
44Abnormality of the vitamin B12 metabolism (HP:0004341)3.18018855
45Abnormality of nucleobase metabolism (HP:0010932)3.13941463
46Delayed CNS myelination (HP:0002188)3.13353750
47Steatorrhea (HP:0002570)3.10834514
48Hyperbilirubinemia (HP:0002904)3.07162958
49Ketoacidosis (HP:0001993)3.07057300
50Abnormality of vitamin B metabolism (HP:0004340)3.01423605
51Widely patent fontanelles and sutures (HP:0004492)3.00471637
52Abnormality of purine metabolism (HP:0004352)2.92767130
53Metabolic acidosis (HP:0001942)2.91634882
54Gout (HP:0001997)2.89526324
55Lethargy (HP:0001254)2.86566139
56Plantar hyperkeratosis (HP:0007556)2.85152927
57Dicarboxylic aciduria (HP:0003215)2.82360356
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82360356
59Vascular calcification (HP:0004934)2.81698689
60Right ventricular cardiomyopathy (HP:0011663)2.73058146
61Spontaneous abortion (HP:0005268)2.70433735
62Pustule (HP:0200039)2.66543912
63Myocardial infarction (HP:0001658)2.66275705
64Hepatocellular carcinoma (HP:0001402)2.66081610
65Hypochromic microcytic anemia (HP:0004840)2.66059816
66Cerebral edema (HP:0002181)2.62885641
67Pili torti (HP:0003777)2.61833123
68Abnormality of chloride homeostasis (HP:0011422)2.61587432
69Vasculitis (HP:0002633)2.61366122
70Palmoplantar hyperkeratosis (HP:0000972)2.59916712
71Increased IgE level (HP:0003212)2.58547257
72Abnormality of small intestinal villus morphology (HP:0011472)2.56741190
73Villous atrophy (HP:0011473)2.56741190
74Malnutrition (HP:0004395)2.51748146
75Abnormality of T cell number (HP:0011839)2.51665674
76Skin nodule (HP:0200036)2.51409449
77Hyperaldosteronism (HP:0000859)2.51306678
78Irritability (HP:0000737)2.45819280
79Cardiovascular calcification (HP:0011915)2.45594055
80Recurrent bronchitis (HP:0002837)2.43928830
81Gastrointestinal stroma tumor (HP:0100723)2.43512834
82Systemic lupus erythematosus (HP:0002725)2.43347548
83Enlarged epiphyses (HP:0010580)2.42138721
84Abnormality of the costochondral junction (HP:0000919)2.41785809
85Onycholysis (HP:0001806)2.39830783
86Palmar hyperkeratosis (HP:0010765)2.39756676
87Hypokalemia (HP:0002900)2.39272887
88Abdominal distention (HP:0003270)2.38051370
89Acanthocytosis (HP:0001927)2.36898343
90Abnormal hair laboratory examination (HP:0003328)2.34835341
91Alopecia of scalp (HP:0002293)2.31976824
92Generalized aminoaciduria (HP:0002909)2.31716893
93Elevated erythrocyte sedimentation rate (HP:0003565)2.31371010
94T lymphocytopenia (HP:0005403)2.31321433
95Dehydration (HP:0001944)2.30959477
96Woolly hair (HP:0002224)2.29592382
97Rickets (HP:0002748)2.29089054
98Abnormality of potassium homeostasis (HP:0011042)2.28311890
99Thin bony cortex (HP:0002753)2.27153983
100Hypophosphatemic rickets (HP:0004912)2.25228088
101Glycosuria (HP:0003076)2.25191578
102Abnormality of urine glucose concentration (HP:0011016)2.25191578
103Alkalosis (HP:0001948)2.25178744
104Vomiting (HP:0002013)2.24901882
105Glomerulonephritis (HP:0000099)2.23554934
106Enlarged kidneys (HP:0000105)2.23425978
107Flat acetabular roof (HP:0003180)2.23322128
108Brushfield spots (HP:0001088)2.23251743
109Stomach cancer (HP:0012126)2.21442512
110Spastic diplegia (HP:0001264)2.21196175
111Pancreatitis (HP:0001733)2.20732857
112Proximal tubulopathy (HP:0000114)2.20601911
113Abnormal gallbladder morphology (HP:0012437)2.19440765
114Amyloidosis (HP:0011034)2.19371080
115Hypoglycemic seizures (HP:0002173)2.18952769
116Neonatal onset (HP:0003623)2.17107763
117Agammaglobulinemia (HP:0004432)2.14466582
118Milia (HP:0001056)2.13371138
119Abnormality of B cell number (HP:0010975)2.12826479
120Fragile nails (HP:0001808)2.11970344
121Abnormality of T cells (HP:0002843)2.11583641
122Renal cortical cysts (HP:0000803)2.11024740
123Cholelithiasis (HP:0001081)2.10773921
124Cholecystitis (HP:0001082)2.09827981
125Abnormal gallbladder physiology (HP:0012438)2.09827981
126Pigmentary retinal degeneration (HP:0001146)2.08286888
127Hyperuricemia (HP:0002149)2.05487261
128Increased purine levels (HP:0004368)2.05487261
129Abnormality of proline metabolism (HP:0010907)2.05480262
130Hydroxyprolinuria (HP:0003080)2.05480262
131Abnormality of macrophages (HP:0004311)2.03845205
132Sensorimotor neuropathy (HP:0007141)2.03245889
133Opisthotonus (HP:0002179)2.03194233
134Pulmonary infiltrates (HP:0002113)2.02945545
135Abnormality of T cell physiology (HP:0011840)2.02312288
136Abnormal delayed hypersensitivity skin test (HP:0002963)2.02189446
137Posterior subcapsular cataract (HP:0007787)2.01322107
138Hematochezia (HP:0002573)1.98615800
139Chronic otitis media (HP:0000389)1.98256843
140Nausea (HP:0002018)1.98091439
141Recurrent sinusitis (HP:0011108)1.96778042
142Mitral stenosis (HP:0001718)1.95646174
143Premature loss of primary teeth (HP:0006323)1.95234153
144Abnormality of vitamin metabolism (HP:0100508)1.94512495
145Menorrhagia (HP:0000132)1.93387660
146Abnormal enzyme/coenzyme activity (HP:0012379)1.91887205
147Recurrent pneumonia (HP:0006532)1.91790595
148Metaphyseal irregularity (HP:0003025)1.90988334
149Hemoptysis (HP:0002105)1.90905178
150Skin rash (HP:0000988)1.89659036
151Hyperkalemia (HP:0002153)1.89240325
152Gingival bleeding (HP:0000225)1.88844107
153Recurrent gram-negative bacterial infections (HP:0005420)1.88636854
154Confusion (HP:0001289)1.88234482
155Hyperparathyroidism (HP:0000843)1.87482564
156Nephrolithiasis (HP:0000787)1.87460538
157Late onset (HP:0003584)1.87074005
158Hyperinsulinemic hypoglycemia (HP:0000825)1.86525698
159Autoimmune hemolytic anemia (HP:0001890)1.86414905
160Dry hair (HP:0011359)1.85718058
161Recurrent bacterial skin infections (HP:0005406)1.85051075
162Abnormal albumin level (HP:0012116)1.84973310
163Hypoalbuminemia (HP:0003073)1.84973310
164Abnormality of glycolipid metabolism (HP:0010969)1.84843533
165Abnormality of liposaccharide metabolism (HP:0010968)1.84843533
166Abnormality of glycosphingolipid metabolism (HP:0004343)1.84843533
167Esophageal varix (HP:0002040)1.83843995
168Vacuolated lymphocytes (HP:0001922)1.82930402
169Hemorrhage of the eye (HP:0011885)1.82445563
170Abnormality of the gallbladder (HP:0005264)1.82241174
171IgM deficiency (HP:0002850)1.81117151
172IgG deficiency (HP:0004315)1.80164785
173Renal tubular acidosis (HP:0001947)1.79896783
174Thick nail (HP:0001805)1.79553980
175Increased circulating renin level (HP:0000848)1.79401368
176Abnormal blistering of the skin (HP:0008066)1.76686010
177Autoimmune thrombocytopenia (HP:0001973)1.75319839
178Abnormality of the nasal mucosa (HP:0000433)1.75142244
179Abnormal cartilage morphology (HP:0002763)1.75120601
180Abnormality of magnesium homeostasis (HP:0004921)1.74726000
181Meningitis (HP:0001287)1.74209482
182Elevated hepatic transaminases (HP:0002910)1.73119272
183Thrombophlebitis (HP:0004418)1.72927020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.03426230
2ACVR1B5.58656927
3FGFR44.23515697
4MAP4K13.79603350
5TXK3.77086238
6SIK13.45848790
7ERN13.33361470
8INSRR3.28451948
9ERBB43.08711082
10MST1R2.99879562
11RIPK42.64384335
12TAOK32.58591762
13STK242.58272720
14MAP2K42.02439911
15PIK3CG1.98518441
16LATS11.90918117
17PRKG21.90096472
18FRK1.89586663
19OXSR11.79288204
20FGFR21.78888764
21STK38L1.76953927
22BMPR21.70891879
23MST41.66367481
24MAPK111.61387486
25STK391.59663249
26ABL21.50889112
27MAP3K121.50116067
28MAP3K21.43794132
29NLK1.42913508
30PRKAA21.36288173
31EPHB11.36026318
32MET1.34628820
33ITK1.33818092
34WNK41.32302844
35LMTK21.28648051
36MAPKAPK31.28271739
37MAPK151.26929418
38RIPK11.24826346
39TEC1.21654001
40IKBKB1.20836139
41MAP3K101.20071406
42MATK1.20005631
43WNK31.19567653
44SYK1.19141424
45PINK11.18733534
46ZAP701.15016246
47BTK1.13612636
48NME21.13350214
49PKN11.12867259
50GRK11.12174443
51PBK1.11264017
52IRAK31.10255251
53EPHA41.10203263
54TYK21.07557130
55MAPK41.07477428
56JAK31.05885259
57TESK11.04636800
58MAP3K31.03983979
59MAP3K11.02927277
60ERBB21.01241581
61MAP3K111.00829306
62MAP3K70.99552534
63DAPK20.98407580
64TESK20.97534835
65PRKCZ0.97459502
66PTK60.96855019
67TGFBR20.96104643
68GRK60.95598877
69EPHA30.95011764
70CSNK1G10.94022106
71CAMK2G0.92065674
72PDK40.91611305
73PDK30.91611305
74ADRBK20.91255417
75GSK3A0.88605458
76FGFR30.88498899
77STK160.88384920
78LCK0.88140250
79JAK20.87574806
80NEK90.87487607
81MAP3K140.79327847
82NUAK10.77778648
83PRKACG0.75961543
84LYN0.75729958
85PASK0.74782039
86PRKAA10.74167574
87KDR0.73839074
88TIE10.72395415
89CSNK1G30.72146137
90FLT30.71699555
91MAPK120.71438153
92IRAK40.71398795
93PDK10.68669823
94DYRK1B0.68461488
95IRAK20.67188519
96PDK20.66863161
97CSNK1G20.66466422
98MAP2K60.65219304
99MAP3K60.64702331
100BLK0.62765270
101KIT0.62527204
102SGK2230.62175858
103SGK4940.62175858
104IRAK10.62150427
105TRPM70.61957764
106PRKCQ0.61596529
107TNIK0.60694517
108PDPK10.58617684
109JAK10.57871184
110TGFBR10.56712862
111CDK60.55278456
112MARK30.54872822
113CSNK1A1L0.53581332
114CSF1R0.52739725
115CAMKK20.52514702
116HCK0.51440713
117CSK0.50931148
118MAP2K20.50680419
119PRKCG0.49287528
120TBK10.49207243
121PIK3CA0.47758330
122MYLK0.46919915
123BCR0.46699284
124PIM10.46545694
125SIK30.46051578
126MAPKAPK20.45257513
127DDR20.44643414
128PAK30.43911585
129FER0.43627738
130BMPR1B0.43537173
131CDC42BPA0.43358863
132MAPK70.42130780
133MAP2K10.41744015
134STK30.41571723
135AKT30.41543075
136CAMK1D0.41040344
137EPHB20.40480237
138PTK20.39843886
139CHUK0.38533983
140IGF1R0.38190791
141STK100.37159798
142PRKCA0.37070483
143CASK0.35089422
144EPHA20.34253905
145PRKACA0.33186377
146MAP3K130.33070814
147PKN20.32894547
148IKBKE0.32475119
149LATS20.31859163
150SGK20.29628277
151SGK30.27286991
152MAP2K30.26523965

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.24962340
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24938940
3Nitrogen metabolism_Homo sapiens_hsa009103.18548297
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94284016
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.86186899
6Arginine biosynthesis_Homo sapiens_hsa002202.80060848
7Allograft rejection_Homo sapiens_hsa053302.78105102
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.72036494
9Asthma_Homo sapiens_hsa053102.69342775
10Tryptophan metabolism_Homo sapiens_hsa003802.66865168
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64666093
12Autoimmune thyroid disease_Homo sapiens_hsa053202.63805496
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.60711330
14Graft-versus-host disease_Homo sapiens_hsa053322.55748232
15Fatty acid degradation_Homo sapiens_hsa000712.49054932
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48792510
17Complement and coagulation cascades_Homo sapiens_hsa046102.48114955
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.36943168
19Butanoate metabolism_Homo sapiens_hsa006502.34919224
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25051498
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20466119
22Type I diabetes mellitus_Homo sapiens_hsa049402.16577141
23Peroxisome_Homo sapiens_hsa041462.14487679
24Propanoate metabolism_Homo sapiens_hsa006402.07348260
25Histidine metabolism_Homo sapiens_hsa003402.05625857
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98038199
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.97622332
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95928226
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94646997
30Chemical carcinogenesis_Homo sapiens_hsa052041.94419191
31Fatty acid metabolism_Homo sapiens_hsa012121.89976035
32PPAR signaling pathway_Homo sapiens_hsa033201.88481445
33Retinol metabolism_Homo sapiens_hsa008301.85234433
34beta-Alanine metabolism_Homo sapiens_hsa004101.84369351
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75567354
36Fatty acid elongation_Homo sapiens_hsa000621.73974872
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.63747097
38Phenylalanine metabolism_Homo sapiens_hsa003601.62274326
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60565224
40Caffeine metabolism_Homo sapiens_hsa002321.60463399
41Staphylococcus aureus infection_Homo sapiens_hsa051501.58228720
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55203929
43Primary immunodeficiency_Homo sapiens_hsa053401.52169029
44Sulfur metabolism_Homo sapiens_hsa009201.50978400
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50606342
46Bile secretion_Homo sapiens_hsa049761.47667490
47Tyrosine metabolism_Homo sapiens_hsa003501.46693237
48Steroid biosynthesis_Homo sapiens_hsa001001.45546207
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43660825
50Selenocompound metabolism_Homo sapiens_hsa004501.39984884
51Pyruvate metabolism_Homo sapiens_hsa006201.39965188
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38807617
53Folate biosynthesis_Homo sapiens_hsa007901.36190400
54Antigen processing and presentation_Homo sapiens_hsa046121.36078501
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31230612
56Vitamin B6 metabolism_Homo sapiens_hsa007501.28988248
57Fat digestion and absorption_Homo sapiens_hsa049751.20655016
58Starch and sucrose metabolism_Homo sapiens_hsa005001.20395969
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.19589816
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.18758899
61Leishmaniasis_Homo sapiens_hsa051401.18143155
62ABC transporters_Homo sapiens_hsa020101.14955687
63Vitamin digestion and absorption_Homo sapiens_hsa049771.12132559
64Rheumatoid arthritis_Homo sapiens_hsa053231.08499763
65Carbon metabolism_Homo sapiens_hsa012001.07818196
66Biosynthesis of amino acids_Homo sapiens_hsa012301.05202683
67Hematopoietic cell lineage_Homo sapiens_hsa046401.05102476
68Arginine and proline metabolism_Homo sapiens_hsa003301.04501411
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.98608080
70Viral myocarditis_Homo sapiens_hsa054160.98342514
71Sulfur relay system_Homo sapiens_hsa041220.92047921
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90411733
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89155991
74Pancreatic secretion_Homo sapiens_hsa049720.88142613
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86630554
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86322500
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.82031105
78Glutathione metabolism_Homo sapiens_hsa004800.80900868
79Toxoplasmosis_Homo sapiens_hsa051450.79490027
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77653371
81Glycerolipid metabolism_Homo sapiens_hsa005610.77553137
82Lysine degradation_Homo sapiens_hsa003100.72803654
83Tuberculosis_Homo sapiens_hsa051520.67539467
84Other glycan degradation_Homo sapiens_hsa005110.64208008
85Fatty acid biosynthesis_Homo sapiens_hsa000610.61802411
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61031052
87T cell receptor signaling pathway_Homo sapiens_hsa046600.60168499
88Influenza A_Homo sapiens_hsa051640.58635415
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57633391
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57140408
91Pentose phosphate pathway_Homo sapiens_hsa000300.56950390
92Pertussis_Homo sapiens_hsa051330.55751095
93Metabolic pathways_Homo sapiens_hsa011000.55179837
94Dorso-ventral axis formation_Homo sapiens_hsa043200.52206450
95B cell receptor signaling pathway_Homo sapiens_hsa046620.51754173
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51539813
97One carbon pool by folate_Homo sapiens_hsa006700.49326571
98Linoleic acid metabolism_Homo sapiens_hsa005910.49275024
99TNF signaling pathway_Homo sapiens_hsa046680.45020642
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42022283
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42020450
102Herpes simplex infection_Homo sapiens_hsa051680.41935247
103Osteoclast differentiation_Homo sapiens_hsa043800.41487862
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40893964
105Phagosome_Homo sapiens_hsa041450.37181466
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36686967
107Lysosome_Homo sapiens_hsa041420.36302347
108Chemokine signaling pathway_Homo sapiens_hsa040620.35987369
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.35436145
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.34779562
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33031747
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30631380
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29824252
114Prion diseases_Homo sapiens_hsa050200.22455644
115Renin secretion_Homo sapiens_hsa049240.22234939
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.22216368
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20400622
118Fructose and mannose metabolism_Homo sapiens_hsa000510.18967218
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.15408928
120Galactose metabolism_Homo sapiens_hsa000520.14152668
121Arachidonic acid metabolism_Homo sapiens_hsa005900.12928627
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10567907
123Insulin resistance_Homo sapiens_hsa049310.10462865
124Ether lipid metabolism_Homo sapiens_hsa005650.06417829
125Ovarian steroidogenesis_Homo sapiens_hsa049130.02671256
126Regulation of autophagy_Homo sapiens_hsa041400.01514191
127Glucagon signaling pathway_Homo sapiens_hsa049220.00277921
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2276828
129Parkinsons disease_Homo sapiens_hsa05012-0.2255131
130Insulin signaling pathway_Homo sapiens_hsa04910-0.2227157
131Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2095821
132Alzheimers disease_Homo sapiens_hsa05010-0.2002790
133Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1957397
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1953271
135Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1904325
136Hepatitis C_Homo sapiens_hsa05160-0.1878881
137Protein digestion and absorption_Homo sapiens_hsa04974-0.1803591
138African trypanosomiasis_Homo sapiens_hsa05143-0.1774339
139Sphingolipid metabolism_Homo sapiens_hsa00600-0.1516643
140Renin-angiotensin system_Homo sapiens_hsa04614-0.0837687
141Oxidative phosphorylation_Homo sapiens_hsa00190-0.0654213
142AMPK signaling pathway_Homo sapiens_hsa04152-0.0275969
143Mineral absorption_Homo sapiens_hsa04978-0.0228130
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0206449

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