AEBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)6.69771239
2NIK/NF-kappaB signaling (GO:0038061)5.26500359
3negative thymic T cell selection (GO:0045060)4.54627615
4negative T cell selection (GO:0043383)4.51537192
5positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.40966477
6replication fork processing (GO:0031297)4.35632678
7negative regulation of DNA-dependent DNA replication (GO:2000104)4.28545923
8myeloid dendritic cell differentiation (GO:0043011)4.18175951
9lactate metabolic process (GO:0006089)4.16953823
10regulation of nuclear cell cycle DNA replication (GO:0033262)4.05931196
11nuclear pore complex assembly (GO:0051292)4.02726124
12positive regulation of gamma-delta T cell activation (GO:0046645)3.98194404
13positive regulation of natural killer cell differentiation (GO:0032825)3.97544764
14regulation of DNA endoreduplication (GO:0032875)3.91648045
15regulation of T-helper 1 cell differentiation (GO:0045625)3.90938640
16regulation of interleukin-12 biosynthetic process (GO:0045075)3.89785415
17regulation of dendritic cell antigen processing and presentation (GO:0002604)3.88085367
18respiratory chain complex IV assembly (GO:0008535)3.83005125
19antigen processing and presentation of endogenous antigen (GO:0019883)3.82040327
20myeloid dendritic cell activation (GO:0001773)3.79312054
21DNA replication checkpoint (GO:0000076)3.67543996
22nuclear pore organization (GO:0006999)3.64217998
23DNA catabolic process, exonucleolytic (GO:0000738)3.58145947
24synapsis (GO:0007129)3.55675656
25thymic T cell selection (GO:0045061)3.54099122
26chromatin remodeling at centromere (GO:0031055)3.47252695
27maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.46536235
28recombinational repair (GO:0000725)3.46142065
29double-strand break repair via homologous recombination (GO:0000724)3.46122402
30platelet dense granule organization (GO:0060155)3.45896275
31regulation of mitotic spindle checkpoint (GO:1903504)3.45073613
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.45073613
33positive thymic T cell selection (GO:0045059)3.44866685
34response to interleukin-15 (GO:0070672)3.43106563
35regulation of meiosis I (GO:0060631)3.40377379
36keratinocyte development (GO:0003334)3.40103378
37regulation of glucokinase activity (GO:0033131)3.39617555
38regulation of hexokinase activity (GO:1903299)3.39617555
39histone exchange (GO:0043486)3.39330615
40T cell selection (GO:0045058)3.37470622
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.35820585
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.35820585
43water-soluble vitamin biosynthetic process (GO:0042364)3.34578948
44proteasome assembly (GO:0043248)3.33250639
45CENP-A containing nucleosome assembly (GO:0034080)3.32224655
46RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.31559814
47positive regulation of interleukin-2 production (GO:0032743)3.31485817
48somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.31272430
49isotype switching (GO:0045190)3.31272430
50somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.31272430
51regulation of interleukin-2 biosynthetic process (GO:0045076)3.29113423
52positive regulation of protein autophosphorylation (GO:0031954)3.28124310
53pore complex assembly (GO:0046931)3.26377377
54regulation of gamma-delta T cell differentiation (GO:0045586)3.25574630
55tyrosine phosphorylation of STAT protein (GO:0007260)3.24105755
56mitochondrial DNA replication (GO:0006264)3.23298154
57tolerance induction (GO:0002507)3.21530623
58cytochrome complex assembly (GO:0017004)3.21114008
59dendritic cell differentiation (GO:0097028)3.15687295
60postreplication repair (GO:0006301)3.13696710
61DNA deamination (GO:0045006)3.11549825
62protein prenylation (GO:0018342)3.08108560
63prenylation (GO:0097354)3.08108560
64positive regulation of isotype switching (GO:0045830)3.07938519
65protein K6-linked ubiquitination (GO:0085020)3.04716406
66negative regulation of JUN kinase activity (GO:0043508)3.04252581
67inositol phosphate catabolic process (GO:0071545)3.04218349
68regulation of alpha-beta T cell proliferation (GO:0046640)3.03503475
69regulation of gamma-delta T cell activation (GO:0046643)3.03421364
70JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.02640289
71positive T cell selection (GO:0043368)3.01952786
72response to pheromone (GO:0019236)3.00579698
73response to X-ray (GO:0010165)3.00366833
74histone H2A acetylation (GO:0043968)3.00098376
75regulation of T-helper cell differentiation (GO:0045622)2.97854147
76negative regulation of cell killing (GO:0031342)2.97397563
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97397563
78somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95735335
79somatic hypermutation of immunoglobulin genes (GO:0016446)2.95735335
80positive regulation of antigen processing and presentation (GO:0002579)2.95421283
81positive regulation of glycoprotein biosynthetic process (GO:0010560)2.91227638
82peptidyl-histidine modification (GO:0018202)2.91203944
83prostate gland growth (GO:0060736)2.90490984
84regulation of centriole replication (GO:0046599)2.90099371
85protein localization to kinetochore (GO:0034501)2.90060461
86positive regulation of alpha-beta T cell proliferation (GO:0046641)2.88222611
87response to muramyl dipeptide (GO:0032495)2.88152738
88positive regulation of T-helper cell differentiation (GO:0045624)2.85135489
89modulation by symbiont of host cellular process (GO:0044068)2.84367050
90regulation of RIG-I signaling pathway (GO:0039535)2.82898632
91T cell costimulation (GO:0031295)2.82378306
92protein K11-linked deubiquitination (GO:0035871)2.80610940
93kinetochore organization (GO:0051383)2.80153037
94cellular response to interleukin-15 (GO:0071350)2.78176068
95regulation of RNA export from nucleus (GO:0046831)2.76728616
96lymphocyte costimulation (GO:0031294)2.76540784
97interferon-gamma production (GO:0032609)2.76510806
98positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76419334
99positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76419334
100positive regulation of mitotic sister chromatid separation (GO:1901970)2.76419334
101telomere maintenance via telomerase (GO:0007004)2.75129162
102negative regulation of translation, ncRNA-mediated (GO:0040033)2.74363545
103regulation of translation, ncRNA-mediated (GO:0045974)2.74363545
104negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74363545
105L-fucose catabolic process (GO:0042355)2.74021183
106fucose catabolic process (GO:0019317)2.74021183
107L-fucose metabolic process (GO:0042354)2.74021183
108female gonad development (GO:0008585)2.73708166
109regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.73526198
110positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.73006738
111positive regulation of T cell cytokine production (GO:0002726)2.71065152
112regulation of isotype switching to IgG isotypes (GO:0048302)2.70462150
113resolution of meiotic recombination intermediates (GO:0000712)2.70368760
114positive regulation of interleukin-12 production (GO:0032735)2.70317241
115polyol catabolic process (GO:0046174)2.70239114
116rRNA methylation (GO:0031167)2.68877465
117branched-chain amino acid catabolic process (GO:0009083)2.68614629
118phosphorylated carbohydrate dephosphorylation (GO:0046838)2.68092962
119inositol phosphate dephosphorylation (GO:0046855)2.68092962
120positive regulation of T-helper 1 type immune response (GO:0002827)2.67279334
121growth hormone receptor signaling pathway (GO:0060396)2.67203171
122regulation of immunoglobulin secretion (GO:0051023)2.67108580
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.66604673
124DNA-dependent DNA replication (GO:0006261)2.66287568
125kidney morphogenesis (GO:0060993)2.65978725
126DNA replication-dependent nucleosome assembly (GO:0006335)2.64416564
127DNA replication-dependent nucleosome organization (GO:0034723)2.64416564
128somatic recombination of immunoglobulin gene segments (GO:0016447)2.64205775
129zinc ion transport (GO:0006829)2.63555626
130negative regulation of neurological system process (GO:0031645)2.62363907
131positive regulation of protein import into nucleus, translocation (GO:0033160)2.61223190
132atrial cardiac muscle cell action potential (GO:0086014)2.60507345
133cullin deneddylation (GO:0010388)2.60335879
134regulation of T-helper 1 type immune response (GO:0002825)2.59912282
135presynaptic membrane assembly (GO:0097105)2.59905774
136T cell migration (GO:0072678)2.59551661
137double-strand break repair (GO:0006302)2.59402704
138positive regulation of humoral immune response (GO:0002922)2.59375695
139regulation of helicase activity (GO:0051095)2.58263571
140natural killer cell differentiation (GO:0001779)2.57266615
141regulation of antigen processing and presentation (GO:0002577)2.57145510
142regulation of interleukin-12 production (GO:0032655)2.57137515
143somatic diversification of immunoglobulins (GO:0016445)2.57074368
144cellular ketone body metabolic process (GO:0046950)2.56769711
145embryonic process involved in female pregnancy (GO:0060136)2.56624781
146exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56557561
147mitotic metaphase plate congression (GO:0007080)2.55710516
148nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54414358
149kinetochore assembly (GO:0051382)2.53427603
150regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.52665408
151positive regulation of DNA recombination (GO:0045911)2.52215438
152CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.52186434
153T-helper cell differentiation (GO:0042093)2.52186434
154detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51951481
155mitotic sister chromatid cohesion (GO:0007064)2.51469203
156natural killer cell mediated cytotoxicity (GO:0042267)2.50169915
157natural killer cell mediated immunity (GO:0002228)2.50169915
158regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.50118800
159regulation of T cell tolerance induction (GO:0002664)2.50059948
160non-recombinational repair (GO:0000726)2.49968131
161double-strand break repair via nonhomologous end joining (GO:0006303)2.49968131
162NLS-bearing protein import into nucleus (GO:0006607)2.49855731
163rRNA modification (GO:0000154)2.49292578
164regulation of response to interferon-gamma (GO:0060330)2.48728396
165signal peptide processing (GO:0006465)2.48157751
166neural tube formation (GO:0001841)2.47628969
167ketone body metabolic process (GO:1902224)2.47030763
168mitotic nuclear envelope disassembly (GO:0007077)2.46273722
169reciprocal DNA recombination (GO:0035825)2.45422053
170reciprocal meiotic recombination (GO:0007131)2.45422053
171lysine catabolic process (GO:0006554)2.45274278
172lysine metabolic process (GO:0006553)2.45274278
173hepatocyte apoptotic process (GO:0097284)2.45179425
174transcription elongation from RNA polymerase I promoter (GO:0006362)2.44220514
175ribosome assembly (GO:0042255)2.43021962
176sister chromatid cohesion (GO:0007062)2.42746148
177regulation of chronic inflammatory response (GO:0002676)2.42694617
178positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.42543106
179positive regulation of B cell mediated immunity (GO:0002714)2.41839720
180positive regulation of immunoglobulin mediated immune response (GO:0002891)2.41839720
181regulation of natural killer cell differentiation (GO:0032823)2.40479714
182regulation of interleukin-2 production (GO:0032663)2.39197277
183regulation of mitotic spindle organization (GO:0060236)2.39134012
184positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.38571780
185regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.38365908
186alpha-beta T cell activation (GO:0046631)2.35960081
187histone H2A monoubiquitination (GO:0035518)2.35669891
188protein localization to chromosome, centromeric region (GO:0071459)2.33885704
189positive regulation of cytokine biosynthetic process (GO:0042108)2.33504627
190neutrophil activation (GO:0042119)2.33278967
191interferon-gamma-mediated signaling pathway (GO:0060333)2.32071268
192nuclear envelope disassembly (GO:0051081)2.31081612
193membrane disassembly (GO:0030397)2.31081612
194regulation of protein import into nucleus, translocation (GO:0033158)2.30949529
195positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.30453973
196positive regulation of natural killer cell mediated immunity (GO:0002717)2.30453973
197regulation of spindle organization (GO:0090224)2.29167151
198negative regulation of interleukin-12 production (GO:0032695)2.28519664
199T cell proliferation (GO:0042098)2.27662852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.21313312
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.75003963
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.81310525
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.95391002
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.93342718
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.66745282
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.44379798
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.22799690
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.08469019
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91644006
11ZNF274_21170338_ChIP-Seq_K562_Hela2.84963788
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71491549
13MYC_22102868_ChIP-Seq_BL_Human2.67688764
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57658660
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57241173
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.55952976
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54339481
18* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54157673
19FUS_26573619_Chip-Seq_HEK293_Human2.51091405
20* VDR_22108803_ChIP-Seq_LS180_Human2.47323680
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.46932033
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.45790191
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45019246
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39246383
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38606310
26EWS_26573619_Chip-Seq_HEK293_Human2.38465266
27* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34028969
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28204634
29* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26647851
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25042054
31GBX2_23144817_ChIP-Seq_PC3_Human2.21089364
32GABP_17652178_ChIP-ChIP_JURKAT_Human2.19349380
33IGF1R_20145208_ChIP-Seq_DFB_Human2.19258281
34* MYB_26560356_Chip-Seq_TH2_Human2.17090268
35EST1_17652178_ChIP-ChIP_JURKAT_Human2.14456742
36* P300_19829295_ChIP-Seq_ESCs_Human2.14152547
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12511744
38TAF15_26573619_Chip-Seq_HEK293_Human2.09017780
39* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.01081151
40MYB_26560356_Chip-Seq_TH1_Human1.98846287
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97664356
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.97329176
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.96333786
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.95953187
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.95610679
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95179657
47* MAF_26560356_Chip-Seq_TH1_Human1.91472314
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85508808
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82585592
50RUNX_20019798_ChIP-Seq_JUKART_Human1.81017547
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79628857
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74418787
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73382175
54* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72226854
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69652435
56* TCF7_22412390_ChIP-Seq_EML_Mouse1.68422850
57VDR_21846776_ChIP-Seq_THP-1_Human1.67586842
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.67189096
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.64716312
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64373996
61* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62868676
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61908620
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56922504
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.53322047
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51299001
66ER_23166858_ChIP-Seq_MCF-7_Human1.51208265
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50453782
68BCAT_22108803_ChIP-Seq_LS180_Human1.50035694
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49166897
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48159090
71VDR_23849224_ChIP-Seq_CD4+_Human1.48035665
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47292412
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.45218977
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.44495433
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44492428
76* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44004784
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43225372
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42212646
79SMAD4_21799915_ChIP-Seq_A2780_Human1.42105991
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41622255
81UTX_26944678_Chip-Seq_JUKART_Human1.41244011
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39696259
83KDM2B_26808549_Chip-Seq_DND41_Human1.38853433
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37454536
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37316685
86MYC_18940864_ChIP-ChIP_HL60_Human1.37220341
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37012479
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36992646
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35980243
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35756642
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.35215281
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34785944
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33761659
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.33355056
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31617212
96AR_21909140_ChIP-Seq_LNCAP_Human1.31429542
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.31285960
98FOXO3_23340844_ChIP-Seq_DLD1_Human1.30697058
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.29534836
100NANOG_19829295_ChIP-Seq_ESCs_Human1.29508341
101SOX2_19829295_ChIP-Seq_ESCs_Human1.29508341
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29097165
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28612230
104CBP_20019798_ChIP-Seq_JUKART_Human1.28612230
105STAT3_23295773_ChIP-Seq_U87_Human1.27130911
106AR_25329375_ChIP-Seq_VCAP_Human1.26874529
107VDR_24763502_ChIP-Seq_THP-1_Human1.26625361
108* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24836059
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24770808
110TCF4_22108803_ChIP-Seq_LS180_Human1.24704057
111* MYC_18555785_ChIP-Seq_MESCs_Mouse1.23489594
112MAF_26560356_Chip-Seq_TH2_Human1.23441738
113* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22808204
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22661857
115SPI1_23547873_ChIP-Seq_NB4_Human1.21806455
116P53_22387025_ChIP-Seq_ESCs_Mouse1.20857007
117* GATA3_27048872_Chip-Seq_THYMUS_Human1.19151595
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18287008
119* RUNX1_22412390_ChIP-Seq_EML_Mouse1.18133090
120* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17915386
121PU_27001747_Chip-Seq_BMDM_Mouse1.17711867
122TCF4_23295773_ChIP-Seq_U87_Human1.15861251
123SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15418461
124P300_18555785_Chip-Seq_ESCs_Mouse1.14399966
125* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13821133
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13005203
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.12663886
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12653488
129CDX2_22108803_ChIP-Seq_LS180_Human1.12203101
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11743347
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11743347
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11650504
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10421245
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09439401
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.08870157
136CMYC_18555785_Chip-Seq_ESCs_Mouse1.08124634
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07340777
138STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07266471
139FOXP3_21729870_ChIP-Seq_TREG_Human1.06999962
140ELK3_25401928_ChIP-Seq_HUVEC_Human1.06926533
141STAT3_18555785_Chip-Seq_ESCs_Mouse1.06413821
142NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06288531
143TP53_22573176_ChIP-Seq_HFKS_Human1.05731347
144SMAD4_21741376_ChIP-Seq_EPCs_Human1.04232402
145* RUNX2_22187159_ChIP-Seq_PCA_Human1.03415634
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03086745
147ELK1_19687146_ChIP-ChIP_HELA_Human1.02936339
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02316463
149KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02109933
150SOX2_18555785_Chip-Seq_ESCs_Mouse1.01432050
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01276253
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01276253
153EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00598861
154FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00566446
155SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99976437
156SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99835685
157UBF1/2_26484160_Chip-Seq_HMECs_Human0.99667017
158* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99319134
159TP63_19390658_ChIP-ChIP_HaCaT_Human0.98637818
160PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97245832
161NCOR1_26117541_ChIP-Seq_K562_Human0.96211035
162KDM2B_26808549_Chip-Seq_JURKAT_Human0.95859663
163TFEB_21752829_ChIP-Seq_HELA_Human0.95231698
164* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94730336
165* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94620172
166VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93344485
167* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92828491
168Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92153639
169ZNF263_19887448_ChIP-Seq_K562_Human0.91817530
170BRD4_25478319_ChIP-Seq_HGPS_Human0.91432513
171NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90866544
172KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90518034
173ATF3_27146783_Chip-Seq_COLON_Human0.88004491
174STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87871477
175* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86719422
176NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85851642
177HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84495726
178VDR_24787735_ChIP-Seq_THP-1_Human0.84454644
179GATA6_25053715_ChIP-Seq_YYC3_Human0.82461064
180E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81947727
181* CHD1_26751641_Chip-Seq_LNCaP_Human0.81361217
182KDM5A_27292631_Chip-Seq_BREAST_Human0.80526930
183P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79973909
184CLOCK_20551151_ChIP-Seq_293T_Human0.79020828
185KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78225477
186NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78136012
187CIITA_25753668_ChIP-Seq_RAJI_Human0.77677037
188FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.77536013
189SPI1_23127762_ChIP-Seq_K562_Human0.77369912
190PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76158838
191TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75140804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.92183253
2MP0000685_abnormal_immune_system3.60662545
3MP0002102_abnormal_ear_morphology3.06702235
4MP0002254_reproductive_system_inflammat3.00102001
5MP0001835_abnormal_antigen_presentation2.97279500
6MP0003195_calcinosis2.89514504
7MP0003787_abnormal_imprinting2.83792838
8MP0002877_abnormal_melanocyte_morpholog2.77684463
9MP0003763_abnormal_thymus_physiology2.68236786
10MP0010352_gastrointestinal_tract_polyps2.66934832
11MP0008057_abnormal_DNA_replication2.59405251
12MP0005671_abnormal_response_to2.55866401
13MP0004510_myositis2.55081076
14MP0001348_abnormal_lacrimal_gland2.54336447
15MP0005387_immune_system_phenotype2.47440802
16MP0001790_abnormal_immune_system2.47440802
17MP0005076_abnormal_cell_differentiation2.37751551
18MP0003300_gastrointestinal_ulcer2.29357381
19MP0002166_altered_tumor_susceptibility2.28684467
20MP0006072_abnormal_retinal_apoptosis2.28426254
21MP0006292_abnormal_olfactory_placode2.24694362
22MP0001800_abnormal_humoral_immune2.23446896
23MP0002006_tumorigenesis2.07451720
24MP0003303_peritoneal_inflammation2.04490774
25MP0005310_abnormal_salivary_gland2.01462961
26MP0005000_abnormal_immune_tolerance2.00498838
27MP0002837_dystrophic_cardiac_calcinosis1.98962427
28MP0002938_white_spotting1.97278169
29MP0001873_stomach_inflammation1.95409725
30MP0003718_maternal_effect1.94242773
31MP0002396_abnormal_hematopoietic_system1.93172111
32MP0003786_premature_aging1.91962358
33MP0003436_decreased_susceptibility_to1.90104367
34MP0002452_abnormal_antigen_presenting1.86517997
35MP0000427_abnormal_hair_cycle1.83902063
36MP0006082_CNS_inflammation1.82988290
37MP0005551_abnormal_eye_electrophysiolog1.82005474
38MP0003121_genomic_imprinting1.81238361
39MP0002405_respiratory_system_inflammati1.80686752
40MP0002723_abnormal_immune_serum1.80607134
41MP0009333_abnormal_splenocyte_physiolog1.80500048
42MP0010307_abnormal_tumor_latency1.80498199
43MP0006054_spinal_hemorrhage1.78800874
44MP0002398_abnormal_bone_marrow1.78258425
45MP0001346_abnormal_lacrimal_gland1.74277907
46MP0005379_endocrine/exocrine_gland_phen1.73572783
47MP0010155_abnormal_intestine_physiology1.71214906
48MP0000372_irregular_coat_pigmentation1.70940767
49MP0001819_abnormal_immune_cell1.70438608
50MP0002420_abnormal_adaptive_immunity1.69439635
51MP0002138_abnormal_hepatobiliary_system1.68407780
52MP0005253_abnormal_eye_physiology1.65557322
53MP0002148_abnormal_hypersensitivity_rea1.64270057
54MP0009785_altered_susceptibility_to1.62020274
55MP0001853_heart_inflammation1.61911801
56MP0003890_abnormal_embryonic-extraembry1.61628397
57MP0009697_abnormal_copulation1.60488502
58MP0010094_abnormal_chromosome_stability1.60198383
59MP0000703_abnormal_thymus_morphology1.60130451
60MP0003693_abnormal_embryo_hatching1.60025786
61MP0002009_preneoplasia1.57764850
62MP0000716_abnormal_immune_system1.55921782
63MP0003448_altered_tumor_morphology1.55541721
64MP0005075_abnormal_melanosome_morpholog1.55119845
65MP0004947_skin_inflammation1.54693008
66MP0003077_abnormal_cell_cycle1.54532228
67MP0005025_abnormal_response_to1.53019223
68MP0001984_abnormal_olfaction1.50838270
69MP0009780_abnormal_chondrocyte_physiolo1.49897632
70MP0003453_abnormal_keratinocyte_physiol1.49115846
71MP0003705_abnormal_hypodermis_morpholog1.48888435
72MP0004808_abnormal_hematopoietic_stem1.48861385
73MP0003111_abnormal_nucleus_morphology1.44888447
74MP0001545_abnormal_hematopoietic_system1.43624032
75MP0005397_hematopoietic_system_phenotyp1.43624032
76MP0004215_abnormal_myocardial_fiber1.42733049
77MP0008995_early_reproductive_senescence1.41793865
78MP0003567_abnormal_fetal_cardiomyocyte1.39990781
79MP0009278_abnormal_bone_marrow1.39409714
80MP0002722_abnormal_immune_system1.38959008
81MP0001485_abnormal_pinna_reflex1.38526047
82MP0008007_abnormal_cellular_replicative1.37862117
83MP0008872_abnormal_physiological_respon1.37681537
84MP0010234_abnormal_vibrissa_follicle1.37472296
85MP0003091_abnormal_cell_migration1.34684111
86MP0002751_abnormal_autonomic_nervous1.33926438
87MP0002234_abnormal_pharynx_morphology1.32342770
88MP0005646_abnormal_pituitary_gland1.29567954
89MP0004957_abnormal_blastocyst_morpholog1.28046492
90MP0000689_abnormal_spleen_morphology1.27255194
91MP0002429_abnormal_blood_cell1.26757417
92MP0002090_abnormal_vision1.25921746
93MP0000350_abnormal_cell_proliferation1.25090508
94MP0005174_abnormal_tail_pigmentation1.24702867
95MP0000647_abnormal_sebaceous_gland1.23994061
96MP0003566_abnormal_cell_adhesion1.23282785
97MP0001188_hyperpigmentation1.18502547
98MP0000631_abnormal_neuroendocrine_gland1.17949519
99MP0002419_abnormal_innate_immunity1.17939202
100MP0000858_altered_metastatic_potential1.17349920
101MP0000733_abnormal_muscle_development1.16992486
102MP0003941_abnormal_skin_development1.16891303
103MP0000490_abnormal_crypts_of1.15451498
104MP0001529_abnormal_vocalization1.15259013
105MP0003122_maternal_imprinting1.14248929
106MP0001929_abnormal_gametogenesis1.12844458
107MP0002736_abnormal_nociception_after1.12523799
108MP0003866_abnormal_defecation1.10606498
109MP0004133_heterotaxia1.10341229
110MP0005084_abnormal_gallbladder_morpholo1.08292760
111MP0002163_abnormal_gland_morphology1.08170665
112MP0005623_abnormal_meninges_morphology1.07631607
113MP0005023_abnormal_wound_healing1.07595969
114MP0009046_muscle_twitch1.06324566
115MP0005389_reproductive_system_phenotype1.05817282
116MP0005220_abnormal_exocrine_pancreas1.05638980
117MP0003880_abnormal_central_pattern1.05368930
118MP0000627_abnormal_mammary_gland1.04540621
119MP0001845_abnormal_inflammatory_respons1.04456843
120MP0002160_abnormal_reproductive_system1.04156385
121MP0000383_abnormal_hair_follicle1.04110850
122MP0005395_other_phenotype1.03683321
123MP0003937_abnormal_limbs/digits/tail_de1.03478919
124MP0000653_abnormal_sex_gland1.03295393
125MP0003137_abnormal_impulse_conducting1.02737883
126MP0003045_fibrosis1.00226296
127MP0005645_abnormal_hypothalamus_physiol0.99833367
128MP0002210_abnormal_sex_determination0.97676069
129MP0003011_delayed_dark_adaptation0.97327316
130MP0001145_abnormal_male_reproductive0.96503638
131MP0002019_abnormal_tumor_incidence0.96389285
132MP0003123_paternal_imprinting0.95817372
133MP0001119_abnormal_female_reproductive0.94638562
134MP0003119_abnormal_digestive_system0.93286495
135MP0001968_abnormal_touch/_nociception0.93207172
136MP0001944_abnormal_pancreas_morphology0.91671811
137MP0008789_abnormal_olfactory_epithelium0.90228564
138MP0003806_abnormal_nucleotide_metabolis0.89755190
139MP0002086_abnormal_extraembryonic_tissu0.89071134
140MP0002933_joint_inflammation0.88570190
141MP0001672_abnormal_embryogenesis/_devel0.88459451
142MP0005380_embryogenesis_phenotype0.88459451
143MP0008875_abnormal_xenobiotic_pharmacok0.87767378
144MP0006036_abnormal_mitochondrial_physio0.87701066
145MP0002088_abnormal_embryonic_growth/wei0.86505792
146MP0003984_embryonic_growth_retardation0.85578578
147MP0000569_abnormal_digit_pigmentation0.85286282
148MP0001216_abnormal_epidermal_layer0.84430355
149MP0001881_abnormal_mammary_gland0.82639042
150MP0003950_abnormal_plasma_membrane0.82488370
151MP0004185_abnormal_adipocyte_glucose0.82393848
152MP0001730_embryonic_growth_arrest0.81853352
153MP0004197_abnormal_fetal_growth/weight/0.81834990
154MP0001533_abnormal_skeleton_physiology0.81730000
155MP0008932_abnormal_embryonic_tissue0.79293437
156MP0002233_abnormal_nose_morphology0.78588136
157MP0000613_abnormal_salivary_gland0.78182705
158MP0001293_anophthalmia0.78070022
159MP0002693_abnormal_pancreas_physiology0.77384931
160MP0001324_abnormal_eye_pigmentation0.76470847
161MP0003943_abnormal_hepatobiliary_system0.76274829
162MP0001764_abnormal_homeostasis0.76234055
163MP0008058_abnormal_DNA_repair0.75989210
164MP0003698_abnormal_male_reproductive0.75411074
165MP0001851_eye_inflammation0.74800273
166MP0000313_abnormal_cell_death0.74517347
167MP0001501_abnormal_sleep_pattern0.74083351
168MP0004043_abnormal_pH_regulation0.73923128
169MP0010678_abnormal_skin_adnexa0.73921829
170MP0009703_decreased_birth_body0.73370436
171MP0005248_abnormal_Harderian_gland0.72864877
172MP0003755_abnormal_palate_morphology0.72586822
173MP0005621_abnormal_cell_physiology0.72448331
174MP0004085_abnormal_heartbeat0.72340971
175MP0000371_diluted_coat_color0.72289031
176MP0001986_abnormal_taste_sensitivity0.70867893
177MP0002277_abnormal_respiratory_mucosa0.68512953
178MP0000377_abnormal_hair_follicle0.67650138
179MP0001697_abnormal_embryo_size0.67410782
180MP0002998_abnormal_bone_remodeling0.67377866
181MP0005367_renal/urinary_system_phenotyp0.66246545
182MP0000516_abnormal_urinary_system0.66246545

Predicted human phenotypes

RankGene SetZ-score
1Recurrent fungal infections (HP:0002841)3.83038567
2Abnormality of T cell number (HP:0011839)3.70437796
3Chronic mucocutaneous candidiasis (HP:0002728)3.59409025
4Recurrent cutaneous fungal infections (HP:0011370)3.59409025
5T lymphocytopenia (HP:0005403)3.49354942
6Abnormality of the labia minora (HP:0012880)3.42611252
7Intestinal atresia (HP:0011100)3.38073174
8Neoplasm of the adrenal cortex (HP:0100641)3.37651041
9Eczematoid dermatitis (HP:0000976)3.31027381
10Pancreatic cysts (HP:0001737)3.19353738
11Hypothermia (HP:0002045)3.11656885
12Recurrent viral infections (HP:0004429)3.10803606
13Abnormality of the fingertips (HP:0001211)3.07102749
14Pancreatic fibrosis (HP:0100732)3.03313404
15True hermaphroditism (HP:0010459)2.98732499
16Thyroiditis (HP:0100646)2.93279698
17Osteolytic defects of the phalanges of the hand (HP:0009771)2.93143658
18Osteolytic defects of the hand bones (HP:0009699)2.93143658
19IgA deficiency (HP:0002720)2.89410583
20Abnormal delayed hypersensitivity skin test (HP:0002963)2.86542813
21Increased IgE level (HP:0003212)2.86013154
22Molar tooth sign on MRI (HP:0002419)2.82994743
23Abnormality of midbrain morphology (HP:0002418)2.82994743
24Abnormality of T cells (HP:0002843)2.81762280
25Stomatitis (HP:0010280)2.79090911
26Retrobulbar optic neuritis (HP:0100654)2.77204141
27Optic neuritis (HP:0100653)2.77204141
28Colon cancer (HP:0003003)2.70917047
29Myositis (HP:0100614)2.69216076
30Aqueductal stenosis (HP:0002410)2.66080279
31Nephronophthisis (HP:0000090)2.62560714
32Persistence of primary teeth (HP:0006335)2.62127866
33Ependymoma (HP:0002888)2.61576151
34Abnormality of the renal cortex (HP:0011035)2.60457670
35Pancreatic islet-cell hyperplasia (HP:0004510)2.59754382
36Methylmalonic acidemia (HP:0002912)2.59386400
37Keratoconjunctivitis (HP:0001096)2.58309508
38Neoplasm of the adrenal gland (HP:0100631)2.54164475
39Elevated erythrocyte sedimentation rate (HP:0003565)2.53613354
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.49991830
41Meckel diverticulum (HP:0002245)2.48603803
42Arterial thrombosis (HP:0004420)2.47989021
43Abnormality of the ileum (HP:0001549)2.47348671
44Hyperinsulinemic hypoglycemia (HP:0000825)2.46644872
45Chronic otitis media (HP:0000389)2.44927494
46IgG deficiency (HP:0004315)2.44718593
47Progressive macrocephaly (HP:0004481)2.44663718
48Thrombocytosis (HP:0001894)2.43586658
49Increased IgM level (HP:0003496)2.43432450
50Recurrent bronchitis (HP:0002837)2.42905229
51Pustule (HP:0200039)2.41035837
52Hypoglycemic seizures (HP:0002173)2.40807524
53Mediastinal lymphadenopathy (HP:0100721)2.37832408
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37577219
55Abnormality of T cell physiology (HP:0011840)2.36335305
56Vasculitis (HP:0002633)2.36058105
57Orchitis (HP:0100796)2.35315125
58Panhypogammaglobulinemia (HP:0003139)2.33634361
59Medial flaring of the eyebrow (HP:0010747)2.31445520
60Abnormality of endocrine pancreas physiology (HP:0012093)2.30121161
61Abnormality of the pancreatic islet cells (HP:0006476)2.30121161
62Abnormality of the renal medulla (HP:0100957)2.29910994
63Autoimmune thrombocytopenia (HP:0001973)2.29452747
64Nasal polyposis (HP:0100582)2.27372524
65Congenital stationary night blindness (HP:0007642)2.27174838
66Gastrointestinal infarctions (HP:0005244)2.25143041
67Increased density of long bones (HP:0006392)2.24598592
68Renal cortical cysts (HP:0000803)2.24385747
69Acute myeloid leukemia (HP:0004808)2.24077621
70Pulmonary infiltrates (HP:0002113)2.24006255
71Rhabdomyosarcoma (HP:0002859)2.22992672
72Abnormality of the preputium (HP:0100587)2.21584929
73Abnormality of the metopic suture (HP:0005556)2.19544381
74Chronic hepatic failure (HP:0100626)2.18431450
75Porencephaly (HP:0002132)2.17452996
76Hyperglycemia (HP:0003074)2.15271368
77Glioma (HP:0009733)2.15225467
78Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14742300
79Eosinophilia (HP:0001880)2.14566144
80Prominent metopic ridge (HP:0005487)2.13554224
81Abnormality of methionine metabolism (HP:0010901)2.13522491
82Astrocytoma (HP:0009592)2.13067283
83Abnormality of the astrocytes (HP:0100707)2.13067283
84Abnormality of the duodenum (HP:0002246)2.11725456
85Breast carcinoma (HP:0003002)2.11522536
86Hypoglycemic coma (HP:0001325)2.10374269
87Ectopic kidney (HP:0000086)2.08954815
88Abnormality of the nasal septum (HP:0000419)2.07872798
89Severe combined immunodeficiency (HP:0004430)2.07424412
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.06851469
91Sloping forehead (HP:0000340)2.05688316
92Chromsome breakage (HP:0040012)2.05646930
93Progressive inability to walk (HP:0002505)2.05054316
94Aplasia/Hypoplasia of the fovea (HP:0008060)2.04927679
95Hypoplasia of the fovea (HP:0007750)2.04927679
96Abnormal lung lobation (HP:0002101)2.03420228
97Abolished electroretinogram (ERG) (HP:0000550)2.02776902
98Acute necrotizing encephalopathy (HP:0006965)2.01501318
99Abnormality of vitamin B metabolism (HP:0004340)2.01375885
100Recurrent skin infections (HP:0001581)2.00313615
101Abnormality of the gastric mucosa (HP:0004295)2.00088703
102Small intestinal stenosis (HP:0012848)1.99979751
103Duodenal stenosis (HP:0100867)1.99979751
104Absent frontal sinuses (HP:0002688)1.99584277
105Attenuation of retinal blood vessels (HP:0007843)1.99492709
106Syringomyelia (HP:0003396)1.99380368
107Spinal cord lesions (HP:0100561)1.99380368
108Leukocytosis (HP:0001974)1.99334885
109Volvulus (HP:0002580)1.99305927
110Combined immunodeficiency (HP:0005387)1.99117461
111Amaurosis fugax (HP:0100576)1.98932572
112Increased CSF lactate (HP:0002490)1.98484743
113Hypergammaglobulinemia (HP:0010702)1.98227772
114Ketoacidosis (HP:0001993)1.98191399
115Gastrointestinal atresia (HP:0002589)1.96106038
116Methylmalonic aciduria (HP:0012120)1.95289809
117Autoimmune hemolytic anemia (HP:0001890)1.94972224
118Emphysema (HP:0002097)1.93839875
119Furrowed tongue (HP:0000221)1.92586882
120Gaze-evoked nystagmus (HP:0000640)1.90069215
121Basal cell carcinoma (HP:0002671)1.90015093
122Acute encephalopathy (HP:0006846)1.89543517
123Hypomagnesemia (HP:0002917)1.89439365
124Hematochezia (HP:0002573)1.89074008
125Abnormality of eosinophils (HP:0001879)1.88875336
126Premature loss of primary teeth (HP:0006323)1.87708540
127Abnormal rod and cone electroretinograms (HP:0008323)1.87257716
128Clubbing of toes (HP:0100760)1.86877613
129Recurrent abscess formation (HP:0002722)1.86211066
130Lymphoma (HP:0002665)1.86199774
131Entropion (HP:0000621)1.82961848
132Embryonal renal neoplasm (HP:0011794)1.82516445
133Tubular atrophy (HP:0000092)1.82269175
134Nephroblastoma (Wilms tumor) (HP:0002667)1.82084004
135Hamartoma of the eye (HP:0010568)1.81667277
136Abnormal drinking behavior (HP:0030082)1.80607091
137Polydipsia (HP:0001959)1.80607091
138Keratoconjunctivitis sicca (HP:0001097)1.80322070
139Sparse lateral eyebrow (HP:0005338)1.79163443
140Abnormality of the fovea (HP:0000493)1.78641123
141Bile duct proliferation (HP:0001408)1.78329834
142Abnormal biliary tract physiology (HP:0012439)1.78329834
143Lip pit (HP:0100267)1.78196212
144Abnormality of the pons (HP:0007361)1.78151661
145Aplasia/Hypoplasia of the spleen (HP:0010451)1.77658910
146Granulocytopenia (HP:0001913)1.77542337
147Fair hair (HP:0002286)1.77470727
148Hemoptysis (HP:0002105)1.77017607
149Sclerocornea (HP:0000647)1.76820787
150Labial hypoplasia (HP:0000066)1.76416947
151Inflammation of the large intestine (HP:0002037)1.75887156
152Enlarged penis (HP:0000040)1.75820832
153Genital tract atresia (HP:0001827)1.75433073
154Cystic liver disease (HP:0006706)1.74957141
155Male pseudohermaphroditism (HP:0000037)1.74927326
156Conjunctival hamartoma (HP:0100780)1.74560595
157Prominent nose (HP:0000448)1.74153953
158Abnormality of cells of the lymphoid lineage (HP:0012140)1.73738926
159Dandy-Walker malformation (HP:0001305)1.73041867
160Renal hypoplasia (HP:0000089)1.73034644
161Biliary tract neoplasm (HP:0100574)1.72965705
162Albinism (HP:0001022)1.72682600
163Mitochondrial inheritance (HP:0001427)1.72673927
164Abnormal biliary tract morphology (HP:0012440)1.72673376
165Congenital primary aphakia (HP:0007707)1.71841548
166Chronic diarrhea (HP:0002028)1.71218086
167Myocardial infarction (HP:0001658)1.71026745
168Squamous cell carcinoma (HP:0002860)1.70756061
169Adrenal hypoplasia (HP:0000835)1.70241157
170Oligodactyly (hands) (HP:0001180)1.69703507
171Peritonitis (HP:0002586)1.68933362
172Large for gestational age (HP:0001520)1.68738274
173Chest pain (HP:0100749)1.68094789
174Recurrent bacterial skin infections (HP:0005406)1.67849929
175Fatigue (HP:0012378)1.67454402
176Subacute progressive viral hepatitis (HP:0006572)1.66973090
177Gastrointestinal inflammation (HP:0004386)1.66826367
178Somatic mutation (HP:0001428)1.64963403
179Encephalitis (HP:0002383)1.64464328
180Abnormality of the nasal mucosa (HP:0000433)1.64122896
181Chronic obstructive pulmonary disease (HP:0006510)1.64043832
182Obstructive lung disease (HP:0006536)1.64043832
183Gastrointestinal stroma tumor (HP:0100723)1.61642100
184Viral hepatitis (HP:0006562)1.61307539
185Rectal prolapse (HP:0002035)1.59739722
186B lymphocytopenia (HP:0010976)1.58437383
187Abnormality of B cell number (HP:0010975)1.58437383
188Leukopenia (HP:0001882)1.58220460
189Deviation of the thumb (HP:0009603)1.58132272
190Lymphopenia (HP:0001888)1.58050314
191Periodontitis (HP:0000704)1.57797334
192Long eyelashes (HP:0000527)1.56644137
193IgM deficiency (HP:0002850)1.56502660
194Abnormality of chromosome stability (HP:0003220)1.53079598
195Blepharitis (HP:0000498)1.52720732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.72136553
2MAP3K144.25317789
3TRIM283.54126265
4JAK33.43836678
5TXK3.21058285
6EIF2AK32.98606243
7MAP4K12.84654040
8CDK122.76562629
9WNK32.74707616
10ERBB32.62269115
11BMPR1B2.46821877
12BRSK22.38900689
13TYK22.37390368
14IKBKB2.30522119
15TNIK2.29095017
16FGFR22.23876372
17MAP4K22.21526819
18CHUK2.20512226
19ACVR1B2.04944681
20MAP3K132.04692126
21EIF2AK11.84716326
22FGFR31.83450102
23FGFR41.81245989
24STK101.79571378
25BUB11.77955149
26JAK11.74604652
27IKBKE1.73544282
28ITK1.70118724
29PIM21.66147786
30ALK1.64957351
31PIM11.61692639
32TBK11.60378245
33EPHB11.59273410
34EEF2K1.59160741
35EPHA31.58687468
36ZAK1.58360978
37GRK11.57191860
38TSSK61.53679491
39STK31.50838346
40NEK21.49865471
41MAP3K101.48073236
42TAF11.46201811
43RPS6KA41.45803652
44LATS11.43676526
45PLK21.41651854
46NUAK11.33013816
47PTK61.31373803
48CDK61.30530448
49ZAP701.29673563
50MELK1.29073381
51STK38L1.26036056
52SIK31.25437985
53CDK41.22745058
54OXSR11.21220319
55NLK1.20827483
56BCR1.18694704
57NEK11.17665067
58STK391.17294104
59PLK41.14182459
60CDC71.10242422
61ADRBK21.09533411
62TRIB31.08875601
63MAPK131.08430465
64MST41.08407358
65CSNK1G11.08277117
66IRAK41.06955509
67VRK21.02989274
68PAK30.99860391
69VRK10.98347604
70HCK0.98131878
71IRAK30.98115763
72CSK0.97238413
73INSRR0.96670702
74EIF2AK20.96165351
75LCK0.94630731
76TGFBR10.94379864
77TEC0.93469771
78FER0.93333201
79JAK20.93238043
80PNCK0.93188493
81STK160.91947228
82BMX0.91585305
83EPHA20.91281235
84CASK0.90187495
85TTN0.89844268
86RAF10.88450262
87PKN20.86004360
88MAP3K80.85173737
89STK40.81901856
90WNK40.80360376
91WEE10.80277704
92LRRK20.79489303
93CHEK10.77919315
94MAP3K30.76507639
95MARK30.74834388
96BRSK10.74510518
97AKT30.74239710
98BMPR20.73769636
99PRKCE0.71812924
100RPS6KB20.71317702
101NEK90.68940641
102PBK0.66622780
103NME20.66552892
104TRPM70.66148122
105DMPK0.65325937
106CDK90.64411803
107CLK10.63446197
108ATR0.63366183
109MTOR0.63350301
110PLK30.63330543
111MAP2K30.60801070
112CSNK1G20.60733752
113BRD40.59711455
114DDR20.58726401
115BTK0.58256880
116STK240.57939743
117CSNK1G30.57686726
118ATM0.56783531
119EPHA40.56590319
120MAPKAPK20.56214585
121SRPK10.55132785
122PASK0.55005000
123PRKCQ0.54257351
124SYK0.52635460
125PDGFRB0.51949428
126MAP3K50.51890610
127AURKB0.49874854
128MAP3K40.49435187
129PRKCG0.48802934
130TAOK10.45747153
131PINK10.45745323
132TTK0.44816983
133EGFR0.44572635
134PHKG20.44502285
135PHKG10.44502285
136FGFR10.44443595
137RPS6KA50.43920407
138MKNK10.43337098
139ABL10.43142574
140PLK10.42995848
141CDK20.42645645
142MKNK20.42366388
143KIT0.41782533
144PAK20.41625135
145RPS6KA10.41518091
146GSK3A0.41448390
147CSNK1A1L0.40892660
148PRKD30.39824432
149IRAK10.39198122
150MAP3K20.38392624
151CDK70.37892186
152ICK0.37746897
153MAPK10.37732361
154PRKCI0.36105709
155SGK20.35354095
156CCNB10.33364189
157YES10.33144802
158CSNK1A10.32422914
159MUSK0.31412128
160PTK2B0.31378280
161ADRBK10.30953124
162MAPKAPK50.29827094
163FLT30.28565166
164CHEK20.26926353
165ROCK10.24288937
166CSNK1D0.23441924
167PDK20.23146190
168DYRK20.22530176
169TIE10.22321041
170ERBB40.21066117
171CAMKK20.21025468
172MAPKAPK30.20991489
173PRKAA20.20969394
174NME10.19580224

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.43595620
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.05212818
3Allograft rejection_Homo sapiens_hsa053302.82662362
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.71275064
5Propanoate metabolism_Homo sapiens_hsa006402.63733591
6Proteasome_Homo sapiens_hsa030502.60686584
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.49701852
8Primary immunodeficiency_Homo sapiens_hsa053402.48981443
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.48427790
10Basal transcription factors_Homo sapiens_hsa030222.36056285
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32860080
12Graft-versus-host disease_Homo sapiens_hsa053322.21833510
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19875189
14Autoimmune thyroid disease_Homo sapiens_hsa053202.18927017
15Vitamin B6 metabolism_Homo sapiens_hsa007502.11531720
16Measles_Homo sapiens_hsa051622.08137459
17Butanoate metabolism_Homo sapiens_hsa006502.00413545
18Asthma_Homo sapiens_hsa053101.97721326
19RNA polymerase_Homo sapiens_hsa030201.96996961
20Leishmaniasis_Homo sapiens_hsa051401.96283782
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95988389
22T cell receptor signaling pathway_Homo sapiens_hsa046601.93926066
23Antigen processing and presentation_Homo sapiens_hsa046121.92445297
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84571824
25Phototransduction_Homo sapiens_hsa047441.82554344
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78983993
27Selenocompound metabolism_Homo sapiens_hsa004501.75980825
28Osteoclast differentiation_Homo sapiens_hsa043801.70257473
29Fatty acid elongation_Homo sapiens_hsa000621.68746759
30p53 signaling pathway_Homo sapiens_hsa041151.67782807
31TNF signaling pathway_Homo sapiens_hsa046681.66090166
32Toxoplasmosis_Homo sapiens_hsa051451.63033916
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.62271488
34Small cell lung cancer_Homo sapiens_hsa052221.57061858
35Herpes simplex infection_Homo sapiens_hsa051681.54482203
36Steroid biosynthesis_Homo sapiens_hsa001001.49982534
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49298004
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49251867
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48097431
40Viral myocarditis_Homo sapiens_hsa054161.46879658
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46808650
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44980017
43Chronic myeloid leukemia_Homo sapiens_hsa052201.44860720
44Type I diabetes mellitus_Homo sapiens_hsa049401.43686465
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40945127
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40460334
47Apoptosis_Homo sapiens_hsa042101.35666538
48Tryptophan metabolism_Homo sapiens_hsa003801.35291424
49B cell receptor signaling pathway_Homo sapiens_hsa046621.35118015
50Caffeine metabolism_Homo sapiens_hsa002321.33891320
51Influenza A_Homo sapiens_hsa051641.31427652
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.31060254
53MicroRNAs in cancer_Homo sapiens_hsa052061.30728545
54Hepatitis B_Homo sapiens_hsa051611.28735416
55Epstein-Barr virus infection_Homo sapiens_hsa051691.25164860
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24897216
57Acute myeloid leukemia_Homo sapiens_hsa052211.22835379
58Nucleotide excision repair_Homo sapiens_hsa034201.22434600
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22318995
60Peroxisome_Homo sapiens_hsa041461.20392933
61Viral carcinogenesis_Homo sapiens_hsa052031.19568386
62HTLV-I infection_Homo sapiens_hsa051661.18990172
63Chemokine signaling pathway_Homo sapiens_hsa040621.18800299
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17121346
65Cell cycle_Homo sapiens_hsa041101.17115870
66Circadian rhythm_Homo sapiens_hsa047101.16451761
67Shigellosis_Homo sapiens_hsa051311.16006414
68Legionellosis_Homo sapiens_hsa051341.15122884
69Pancreatic cancer_Homo sapiens_hsa052121.12562691
70RNA transport_Homo sapiens_hsa030131.11956042
71Hematopoietic cell lineage_Homo sapiens_hsa046401.10302645
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10073036
73Prolactin signaling pathway_Homo sapiens_hsa049171.09961960
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01883692
75Ether lipid metabolism_Homo sapiens_hsa005651.01788807
76Purine metabolism_Homo sapiens_hsa002301.01597694
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01108286
78Regulation of autophagy_Homo sapiens_hsa041401.00092371
79Nitrogen metabolism_Homo sapiens_hsa009100.99221398
80beta-Alanine metabolism_Homo sapiens_hsa004100.98096139
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97464247
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97083500
83Oxidative phosphorylation_Homo sapiens_hsa001900.96683760
84Oocyte meiosis_Homo sapiens_hsa041140.96574689
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93112286
86Tuberculosis_Homo sapiens_hsa051520.91758803
87Linoleic acid metabolism_Homo sapiens_hsa005910.91115258
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.90421651
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89926772
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.89181796
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89035420
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87977308
93Malaria_Homo sapiens_hsa051440.87734298
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85718895
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85064729
96Prostate cancer_Homo sapiens_hsa052150.84987120
97mRNA surveillance pathway_Homo sapiens_hsa030150.82271663
98Pyruvate metabolism_Homo sapiens_hsa006200.82261902
99Proteoglycans in cancer_Homo sapiens_hsa052050.80690131
100Adherens junction_Homo sapiens_hsa045200.80279700
101Hepatitis C_Homo sapiens_hsa051600.79183213
102Spliceosome_Homo sapiens_hsa030400.78916134
103FoxO signaling pathway_Homo sapiens_hsa040680.78856030
104Retinol metabolism_Homo sapiens_hsa008300.77723737
105mTOR signaling pathway_Homo sapiens_hsa041500.77593540
106DNA replication_Homo sapiens_hsa030300.77356477
107Dorso-ventral axis formation_Homo sapiens_hsa043200.76736282
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76614373
109Pyrimidine metabolism_Homo sapiens_hsa002400.74239993
110Non-homologous end-joining_Homo sapiens_hsa034500.73415154
111Fatty acid degradation_Homo sapiens_hsa000710.71569836
112MAPK signaling pathway_Homo sapiens_hsa040100.71468201
113One carbon pool by folate_Homo sapiens_hsa006700.70345085
114Pertussis_Homo sapiens_hsa051330.70237984
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70201822
116Parkinsons disease_Homo sapiens_hsa050120.69471074
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.69436477
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68802145
119VEGF signaling pathway_Homo sapiens_hsa043700.68332474
120Renal cell carcinoma_Homo sapiens_hsa052110.67985290
121TGF-beta signaling pathway_Homo sapiens_hsa043500.67580837
122Salmonella infection_Homo sapiens_hsa051320.67562704
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66591651
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66544040
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66526248
126Colorectal cancer_Homo sapiens_hsa052100.66507713
127HIF-1 signaling pathway_Homo sapiens_hsa040660.66398628
128Fatty acid metabolism_Homo sapiens_hsa012120.66178434
129Sulfur metabolism_Homo sapiens_hsa009200.66158097
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65346700
131Pathways in cancer_Homo sapiens_hsa052000.64842903
132Non-small cell lung cancer_Homo sapiens_hsa052230.64444830
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64264193
134Focal adhesion_Homo sapiens_hsa045100.61956977
135Glutathione metabolism_Homo sapiens_hsa004800.60862946
136Chemical carcinogenesis_Homo sapiens_hsa052040.60559403
137Hedgehog signaling pathway_Homo sapiens_hsa043400.59927983
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58223697
139Metabolic pathways_Homo sapiens_hsa011000.57882819
140Amoebiasis_Homo sapiens_hsa051460.57681610
141RNA degradation_Homo sapiens_hsa030180.57633833
142Base excision repair_Homo sapiens_hsa034100.57481836
143Rheumatoid arthritis_Homo sapiens_hsa053230.57186161
144Insulin secretion_Homo sapiens_hsa049110.56800157
145Notch signaling pathway_Homo sapiens_hsa043300.56333319
146Thyroid cancer_Homo sapiens_hsa052160.55656951
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55124535
148Lysine degradation_Homo sapiens_hsa003100.54234688
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53757217
150Taste transduction_Homo sapiens_hsa047420.51419490
151Homologous recombination_Homo sapiens_hsa034400.50762125
152Hippo signaling pathway_Homo sapiens_hsa043900.50306201
153African trypanosomiasis_Homo sapiens_hsa051430.49632438
154Platelet activation_Homo sapiens_hsa046110.49511103
155Vitamin digestion and absorption_Homo sapiens_hsa049770.48816853
156SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48755298
157Adipocytokine signaling pathway_Homo sapiens_hsa049200.47736631
158Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46995334
159Fanconi anemia pathway_Homo sapiens_hsa034600.46461995
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46042738
161Steroid hormone biosynthesis_Homo sapiens_hsa001400.45766637
162Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45662555
163Folate biosynthesis_Homo sapiens_hsa007900.45234329
164Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45053004
165Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44779297
166Mismatch repair_Homo sapiens_hsa034300.44122403
167Collecting duct acid secretion_Homo sapiens_hsa049660.43731425
168Endometrial cancer_Homo sapiens_hsa052130.43573350
169Melanoma_Homo sapiens_hsa052180.43418051
170Olfactory transduction_Homo sapiens_hsa047400.41047716
171Huntingtons disease_Homo sapiens_hsa050160.39902370
172Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39362951
173Wnt signaling pathway_Homo sapiens_hsa043100.38351239
174Mineral absorption_Homo sapiens_hsa049780.38060061
175Glycerolipid metabolism_Homo sapiens_hsa005610.37300359
176Serotonergic synapse_Homo sapiens_hsa047260.35213221
177Sphingolipid metabolism_Homo sapiens_hsa006000.34353596
178Nicotine addiction_Homo sapiens_hsa050330.32774069
1792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28875634

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