AES

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)4.66876945
2lysine metabolic process (GO:0006553)4.56743079
3lysine catabolic process (GO:0006554)4.56743079
4negative regulation of erythrocyte differentiation (GO:0045647)4.27594431
5L-phenylalanine metabolic process (GO:0006558)4.24575049
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.24575049
7regulation of ARF protein signal transduction (GO:0032012)4.20054016
8negative regulation of cell killing (GO:0031342)4.17099359
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.17099359
10L-phenylalanine catabolic process (GO:0006559)4.15646305
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.15646305
122-oxoglutarate metabolic process (GO:0006103)3.98012081
13alpha-linolenic acid metabolic process (GO:0036109)3.97411331
14synaptic vesicle exocytosis (GO:0016079)3.96373135
15glutamate secretion (GO:0014047)3.87635439
16synaptic vesicle maturation (GO:0016188)3.85855170
17aspartate family amino acid catabolic process (GO:0009068)3.81145139
18glyoxylate metabolic process (GO:0046487)3.76256415
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64206192
20signal complex assembly (GO:0007172)3.61782768
21regulation of cholesterol homeostasis (GO:2000188)3.51932849
22kynurenine metabolic process (GO:0070189)3.51463920
23triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.50641632
24carnitine shuttle (GO:0006853)3.50123103
25cellular ketone body metabolic process (GO:0046950)3.49162918
26dicarboxylic acid biosynthetic process (GO:0043650)3.45524612
27regulation of synaptic vesicle exocytosis (GO:2000300)3.42732254
28fatty acid transmembrane transport (GO:1902001)3.42469187
29sulfur amino acid catabolic process (GO:0000098)3.41869125
30positive regulation of Rap GTPase activity (GO:0032854)3.41548805
31aromatic amino acid family catabolic process (GO:0009074)3.38366678
32antigen processing and presentation of endogenous antigen (GO:0019883)3.37820999
33cerebellar granule cell differentiation (GO:0021707)3.37433100
34positive regulation of synapse maturation (GO:0090129)3.37271277
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.36972077
36positive thymic T cell selection (GO:0045059)3.36870457
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34831169
38cysteine metabolic process (GO:0006534)3.33805847
39thymic T cell selection (GO:0045061)3.30833944
40cellular potassium ion homeostasis (GO:0030007)3.29757825
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29048705
42tricarboxylic acid metabolic process (GO:0072350)3.28126564
43regulation of fatty acid beta-oxidation (GO:0031998)3.25900120
44fatty acid beta-oxidation (GO:0006635)3.24319953
45positive regulation of fatty acid beta-oxidation (GO:0032000)3.22649734
46glutamate metabolic process (GO:0006536)3.21589074
47short-chain fatty acid metabolic process (GO:0046459)3.21398294
48plasma membrane repair (GO:0001778)3.21302435
49negative regulation of potassium ion transmembrane transport (GO:1901380)3.19552222
50cellular modified amino acid catabolic process (GO:0042219)3.18010554
51negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16071391
52negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.14683991
53oxaloacetate metabolic process (GO:0006107)3.12670917
54regulation of fatty acid oxidation (GO:0046320)3.12295580
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.12285320
56acetyl-CoA metabolic process (GO:0006084)3.12129927
57positive regulation of gamma-delta T cell activation (GO:0046645)3.10314115
58sarcomere organization (GO:0045214)3.08142979
59tricarboxylic acid cycle (GO:0006099)3.07569837
60bile acid biosynthetic process (GO:0006699)3.07491151
61amino-acid betaine metabolic process (GO:0006577)3.04973304
62regulation of triglyceride catabolic process (GO:0010896)3.02475724
63ketone body metabolic process (GO:1902224)3.00774246
64fatty acid oxidation (GO:0019395)2.96347030
65negative regulation of fibrinolysis (GO:0051918)2.96331369
66fatty acid catabolic process (GO:0009062)2.93797462
674-hydroxyproline metabolic process (GO:0019471)2.93255236
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.92266932
69positive regulation of fatty acid oxidation (GO:0046321)2.91893207
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91868309
71regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.91023613
72lipid oxidation (GO:0034440)2.90324554
73negative regulation of cell size (GO:0045792)2.90292112
74ethanol oxidation (GO:0006069)2.90111065
75regulation of short-term neuronal synaptic plasticity (GO:0048172)2.89374538
76valine metabolic process (GO:0006573)2.87581560
77response to mercury ion (GO:0046689)2.86676663
78urea cycle (GO:0000050)2.86198897
79urea metabolic process (GO:0019627)2.86198897
80monocarboxylic acid catabolic process (GO:0072329)2.85025783
81regulation of Rap GTPase activity (GO:0032317)2.84794113
82high-density lipoprotein particle remodeling (GO:0034375)2.84015889
83negative regulation of cholesterol transport (GO:0032375)2.80777624
84negative regulation of sterol transport (GO:0032372)2.80777624
85protein carboxylation (GO:0018214)2.80416911
86peptidyl-glutamic acid carboxylation (GO:0017187)2.80416911
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80341619
88T cell selection (GO:0045058)2.78541363
89regulation of synaptic vesicle transport (GO:1902803)2.78139407
90positive T cell selection (GO:0043368)2.78102880
91positive regulation of protein dephosphorylation (GO:0035307)2.77081387
92NADH metabolic process (GO:0006734)2.76723552
93negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.76459479
94serine family amino acid catabolic process (GO:0009071)2.76169940
95positive regulation of lipid catabolic process (GO:0050996)2.76028239
96dicarboxylic acid catabolic process (GO:0043649)2.75905254
97positive regulation of triglyceride metabolic process (GO:0090208)2.75715454
98alpha-amino acid catabolic process (GO:1901606)2.75700663
99positive regulation of triglyceride biosynthetic process (GO:0010867)2.75673860
100regulation of ARF GTPase activity (GO:0032312)2.75375122
101cardiac myofibril assembly (GO:0055003)2.75067520
102tryptophan catabolic process (GO:0006569)2.75000809
103indole-containing compound catabolic process (GO:0042436)2.75000809
104indolalkylamine catabolic process (GO:0046218)2.75000809
105locomotory exploration behavior (GO:0035641)2.73876970
106neurotransmitter secretion (GO:0007269)2.73496756
107homocysteine metabolic process (GO:0050667)2.73306408
108carnitine transport (GO:0015879)2.73187541
109amino-acid betaine transport (GO:0015838)2.73187541
110regulation of gamma-delta T cell differentiation (GO:0045586)2.73186428
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.72718822
112cellular amino acid catabolic process (GO:0009063)2.72469412
113cell communication by electrical coupling (GO:0010644)2.72434660
114succinate metabolic process (GO:0006105)2.72107045
115cell communication involved in cardiac conduction (GO:0086065)2.71452085
116activation of protein kinase A activity (GO:0034199)2.70841417
117negative thymic T cell selection (GO:0045060)2.69874572
118mannose metabolic process (GO:0006013)2.69489565
119carnitine transmembrane transport (GO:1902603)2.68243203
120cardiac muscle contraction (GO:0060048)2.66849487
121sodium ion export (GO:0071436)2.66307436
122nitrogen cycle metabolic process (GO:0071941)2.65108653
123regulation of synapse maturation (GO:0090128)2.64719024
124creatine metabolic process (GO:0006600)2.64359635
125negative T cell selection (GO:0043383)2.64128489
126membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64048549
127carnitine metabolic process (GO:0009437)2.62342461
128complement activation, alternative pathway (GO:0006957)2.61901193
129peptidyl-tyrosine autophosphorylation (GO:0038083)2.60851914
130bile acid metabolic process (GO:0008206)2.60263848
131coenzyme catabolic process (GO:0009109)2.59320434
132drug catabolic process (GO:0042737)2.59102707
133triglyceride homeostasis (GO:0070328)2.58248260
134acylglycerol homeostasis (GO:0055090)2.58248260
135plasma lipoprotein particle clearance (GO:0034381)2.58105352
136phospholipid homeostasis (GO:0055091)2.57537061
137regulation of gamma-delta T cell activation (GO:0046643)2.56884184
138L-amino acid import (GO:0043092)2.56774284
139regulation of extracellular matrix disassembly (GO:0010715)2.56626074
140reverse cholesterol transport (GO:0043691)2.55221927
141ventricular cardiac muscle cell action potential (GO:0086005)2.53925796
142positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53642317
143organic acid catabolic process (GO:0016054)2.52578333
144carboxylic acid catabolic process (GO:0046395)2.52578333
145tryptophan metabolic process (GO:0006568)2.51745521
146regulation of fibrinolysis (GO:0051917)2.51421891
147activation of MAPKKK activity (GO:0000185)2.50515045
148positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.48622101
149regulation of neuronal synaptic plasticity (GO:0048168)2.47077357
150regulation of fatty acid biosynthetic process (GO:0042304)2.46688521
151leukocyte aggregation (GO:0070486)2.46355002
152protein targeting to plasma membrane (GO:0072661)2.44966051
153tolerance induction (GO:0002507)2.44646877
154negative regulation of leukocyte mediated immunity (GO:0002704)2.42882031
155response to laminar fluid shear stress (GO:0034616)2.38871832
156negative regulation of lymphocyte mediated immunity (GO:0002707)2.37187062
157neuromuscular process controlling balance (GO:0050885)2.35403183
158dopamine receptor signaling pathway (GO:0007212)2.35281253
159regulation of early endosome to late endosome transport (GO:2000641)2.35042918
160cellular response to monoamine stimulus (GO:0071868)2.33985491
161cellular response to catecholamine stimulus (GO:0071870)2.33985491
162regulation of T-helper 2 cell differentiation (GO:0045628)2.33155541
163regulation of defense response to virus by virus (GO:0050690)2.31952617
164barbed-end actin filament capping (GO:0051016)2.30507157
165potassium ion homeostasis (GO:0055075)2.30200373
166protein localization to endosome (GO:0036010)2.29828115
167response to parathyroid hormone (GO:0071107)2.29065613
168neuronal ion channel clustering (GO:0045161)2.27200782
169regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.25543026
170regulation of synaptic plasticity (GO:0048167)2.24688404
171negative regulation of type 2 immune response (GO:0002829)2.23748130
172positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.22936070
173amino acid import (GO:0043090)2.22893693
174activation of JUN kinase activity (GO:0007257)2.21524351
175regulation of B cell receptor signaling pathway (GO:0050855)2.20316495
176B cell receptor signaling pathway (GO:0050853)2.20011713
177positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.19985847
178positive regulation of fibroblast migration (GO:0010763)2.19639487
179cellular response to epinephrine stimulus (GO:0071872)2.18309917
180positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.18274915
181regulation of voltage-gated calcium channel activity (GO:1901385)2.16919878
182regulation of long-term neuronal synaptic plasticity (GO:0048169)2.16089117
183regulation of protein dephosphorylation (GO:0035304)2.15875870
184detection of bacterium (GO:0016045)2.13218130
185regulation of synapse structural plasticity (GO:0051823)2.12514710
186adherens junction assembly (GO:0034333)2.10753309
187layer formation in cerebral cortex (GO:0021819)2.09804783
188potassium ion import (GO:0010107)2.09753280
189negative regulation of myotube differentiation (GO:0010832)2.09327870
190regulation of glutamate receptor signaling pathway (GO:1900449)2.09192558
191cell-substrate adherens junction assembly (GO:0007045)2.09054240
192focal adhesion assembly (GO:0048041)2.09054240
193adenosine receptor signaling pathway (GO:0001973)2.08926203
194positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.08071868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.78564937
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.53584919
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.16729904
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.79638030
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.35721771
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.69615528
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.57808739
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30143877
9LXR_22292898_ChIP-Seq_THP-1_Human2.24804949
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19436253
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18717516
12ZNF263_19887448_ChIP-Seq_K562_Human2.10943273
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.03894236
14CLOCK_20551151_ChIP-Seq_293T_Human1.98323201
15KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88665070
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.72733778
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71836361
18IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71540663
19KDM2B_26808549_Chip-Seq_DND41_Human1.71061502
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69886693
21* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68975331
22* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64206772
23RACK7_27058665_Chip-Seq_MCF-7_Human1.63891764
24KDM2B_26808549_Chip-Seq_K562_Human1.60303518
25DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58919713
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57641525
27* MAF_26560356_Chip-Seq_TH1_Human1.56365377
28TBX20_22328084_ChIP-Seq_HEART_Mouse1.55176722
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.55176722
30* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54972160
31* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53799252
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50911574
33VDR_24763502_ChIP-Seq_THP-1_Human1.49027236
34* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48081917
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.43751911
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43447620
37UTX_26944678_Chip-Seq_JUKART_Human1.40518037
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.37841772
39CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37538251
40DROSHA_22980978_ChIP-Seq_HELA_Human1.37117888
41CREB1_26743006_Chip-Seq_LNCaP_Human1.35441739
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35379077
43* MAF_26560356_Chip-Seq_TH2_Human1.35290827
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34932379
45* FOXA2_19822575_ChIP-Seq_HepG2_Human1.32896046
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32885507
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32686284
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.30618131
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.28685075
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27995641
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26954809
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.26463458
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26012918
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25156045
55* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24353688
56* TCF7_22412390_ChIP-Seq_EML_Mouse1.23704992
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22950621
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22444042
59EZH2_22144423_ChIP-Seq_EOC_Human1.22241466
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.22238966
61CTCF_27219007_Chip-Seq_Bcells_Human1.21772982
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.20903190
63* P68_20966046_ChIP-Seq_HELA_Human1.20193749
64* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19311591
65GATA1_19941826_ChIP-Seq_K562_Human1.18442503
66* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17065222
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16797788
68SPI1_23127762_ChIP-Seq_K562_Human1.15323360
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.15256623
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14088787
71* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13867446
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.13220767
73RUNX_20019798_ChIP-Seq_JUKART_Human1.13192247
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13151737
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12187284
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.11980711
77SMC4_20622854_ChIP-Seq_HELA_Human1.11729890
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11324096
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09865061
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09557581
81SA1_27219007_Chip-Seq_Bcells_Human1.08094396
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07939520
83* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06955079
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06801124
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06662867
86ATF3_27146783_Chip-Seq_COLON_Human1.06275232
87BP1_19119308_ChIP-ChIP_Hs578T_Human1.05576072
88TET1_21490601_ChIP-Seq_MESCs_Mouse1.05563952
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04031652
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03497313
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03482936
92* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02701784
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.01788886
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01352904
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01202107
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.01187299
97SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01122187
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.01096728
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00517248
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00250545
101TP63_22573176_ChIP-Seq_HFKS_Human1.00128256
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99037548
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98626743
104* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97740464
105* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97143633
106BCOR_27268052_Chip-Seq_Bcells_Human0.96917360
107STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96370081
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.96042393
109RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95997248
110EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95997248
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95858625
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94652014
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93429372
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93409085
115MYC_22102868_ChIP-Seq_BL_Human0.93047216
116FOXO3_23340844_ChIP-Seq_DLD1_Human0.92962521
117EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92731413
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91898894
119* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90932737
120* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90709756
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.90525364
122CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89647856
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.88862455
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88689500
125EZH2_27294783_Chip-Seq_ESCs_Mouse0.87896391
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86884177
127VDR_21846776_ChIP-Seq_THP-1_Human0.86291568
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.86128290
129BCL6_27268052_Chip-Seq_Bcells_Human0.85271276
130* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85042274
131SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84936523
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84925957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.64398767
2MP0005360_urolithiasis4.49750419
3MP0002837_dystrophic_cardiac_calcinosis3.85267554
4MP0005085_abnormal_gallbladder_physiolo3.57888700
5MP0005365_abnormal_bile_salt3.43577530
6MP0000751_myopathy2.90649441
7MP0003705_abnormal_hypodermis_morpholog2.64776198
8MP0008875_abnormal_xenobiotic_pharmacok2.61954099
9MP0005083_abnormal_biliary_tract2.60951549
10MP0003252_abnormal_bile_duct2.60707269
11MP0009840_abnormal_foam_cell2.45516635
12MP0004084_abnormal_cardiac_muscle2.38169243
13MP0004270_analgesia2.38033359
14MP0003436_decreased_susceptibility_to2.36533073
15MP0004130_abnormal_muscle_cell2.34954733
16MP0010329_abnormal_lipoprotein_level2.24520688
17MP0003635_abnormal_synaptic_transmissio2.23842982
18MP0008569_lethality_at_weaning2.22885684
19MP0003646_muscle_fatigue2.21762725
20MP0003879_abnormal_hair_cell2.11685062
21MP0003195_calcinosis2.11532176
22MP0004036_abnormal_muscle_relaxation2.08805859
23MP0003763_abnormal_thymus_physiology2.08264226
24MP0005423_abnormal_somatic_nervous2.04267215
25MP0005332_abnormal_amino_acid1.97237111
26MP0005330_cardiomyopathy1.94178100
27MP0002064_seizures1.92091796
28MP0001666_abnormal_nutrient_absorption1.89798121
29MP0002909_abnormal_adrenal_gland1.88765995
30MP0001348_abnormal_lacrimal_gland1.86117318
31MP0003690_abnormal_glial_cell1.86019611
32MP0004087_abnormal_muscle_fiber1.79331694
33MP0008961_abnormal_basal_metabolism1.79005285
34MP0003806_abnormal_nucleotide_metabolis1.78508925
35MP0000749_muscle_degeneration1.77185237
36MP0002063_abnormal_learning/memory/cond1.74719111
37MP0003172_abnormal_lysosome_physiology1.74277844
38MP0004215_abnormal_myocardial_fiber1.66987953
39MP0003880_abnormal_central_pattern1.64555069
40MP0003191_abnormal_cellular_cholesterol1.63863474
41MP0002118_abnormal_lipid_homeostasis1.63668962
42MP0000747_muscle_weakness1.63631644
43MP0005451_abnormal_body_composition1.61224585
44MP0002269_muscular_atrophy1.60574579
45MP0004043_abnormal_pH_regulation1.58579174
46MP0003300_gastrointestinal_ulcer1.51885110
47MP0003279_aneurysm1.47918137
48MP0005409_darkened_coat_color1.47048583
49MP0003329_amyloid_beta_deposits1.46105400
50MP0008260_abnormal_autophagy1.45197648
51MP0002822_catalepsy1.43281528
52MP0005387_immune_system_phenotype1.42004728
53MP0001790_abnormal_immune_system1.42004728
54MP0005000_abnormal_immune_tolerance1.41856054
55MP0003283_abnormal_digestive_organ1.40008655
56MP0004947_skin_inflammation1.39817395
57MP0001501_abnormal_sleep_pattern1.38993240
58MP0005666_abnormal_adipose_tissue1.38458784
59MP0009780_abnormal_chondrocyte_physiolo1.38395275
60MP0004145_abnormal_muscle_electrophysio1.37364583
61MP0005319_abnormal_enzyme/_coenzyme1.36727585
62MP0004859_abnormal_synaptic_plasticity1.36617527
63MP0000920_abnormal_myelination1.36084980
64MP0000609_abnormal_liver_physiology1.35789159
65MP0009745_abnormal_behavioral_response1.35430576
66MP0003724_increased_susceptibility_to1.33552320
67MP0009643_abnormal_urine_homeostasis1.31996366
68MP0005025_abnormal_response_to1.30896800
69MP0002734_abnormal_mechanical_nocicepti1.30334352
70MP0005584_abnormal_enzyme/coenzyme_acti1.30330729
71MP0002138_abnormal_hepatobiliary_system1.29216041
72MP0002972_abnormal_cardiac_muscle1.28632597
73MP0005620_abnormal_muscle_contractility1.27011292
74MP0004185_abnormal_adipocyte_glucose1.25870711
75MP0000685_abnormal_immune_system1.25417627
76MP0003866_abnormal_defecation1.24956825
77MP0001800_abnormal_humoral_immune1.24273277
78MP0005166_decreased_susceptibility_to1.23354626
79MP0010630_abnormal_cardiac_muscle1.23106636
80MP0005671_abnormal_response_to1.23076651
81MP0000750_abnormal_muscle_regeneration1.22543645
82MP0009278_abnormal_bone_marrow1.21014322
83MP0003137_abnormal_impulse_conducting1.19310252
84MP0000759_abnormal_skeletal_muscle1.17947161
85MP0010234_abnormal_vibrissa_follicle1.17665609
86MP0006036_abnormal_mitochondrial_physio1.17492686
87MP0008775_abnormal_heart_ventricle1.17117400
88MP0001544_abnormal_cardiovascular_syste1.16153066
89MP0005385_cardiovascular_system_phenoty1.16153066
90MP0005375_adipose_tissue_phenotype1.15410748
91MP0002106_abnormal_muscle_physiology1.15211074
92MP0010155_abnormal_intestine_physiology1.13896508
93MP0001849_ear_inflammation1.13292641
94MP0002572_abnormal_emotion/affect_behav1.12760149
95MP0002420_abnormal_adaptive_immunity1.12216365
96MP0002078_abnormal_glucose_homeostasis1.11983983
97MP0006082_CNS_inflammation1.11056069
98MP0000013_abnormal_adipose_tissue1.10877520
99MP0004858_abnormal_nervous_system1.10438904
100MP0004233_abnormal_muscle_weight1.10384647
101MP0001819_abnormal_immune_cell1.09757709
102MP0000678_abnormal_parathyroid_gland1.09660578
103MP0001851_eye_inflammation1.09498929
104MP0001533_abnormal_skeleton_physiology1.09429777
105MP0003091_abnormal_cell_migration1.08736003
106MP0002419_abnormal_innate_immunity1.08541680
107MP0002933_joint_inflammation1.08328771
108MP0002272_abnormal_nervous_system1.08118135
109MP0006138_congestive_heart_failure1.07892518
110MP0009333_abnormal_splenocyte_physiolog1.07579659
111MP0002723_abnormal_immune_serum1.05069330
112MP0005670_abnormal_white_adipose1.05002588
113MP0002249_abnormal_larynx_morphology1.03814801
114MP0004019_abnormal_vitamin_homeostasis1.02596142
115MP0000604_amyloidosis1.02374469
116MP0001765_abnormal_ion_homeostasis1.00663144
117MP0001835_abnormal_antigen_presentation1.00590209
118MP0001502_abnormal_circadian_rhythm0.99992507
119MP0005167_abnormal_blood-brain_barrier0.99929186
120MP0004085_abnormal_heartbeat0.99487618
121MP0004510_myositis0.99276013
122MP0001873_stomach_inflammation0.97918285
123MP0000003_abnormal_adipose_tissue0.97192422
124MP0002998_abnormal_bone_remodeling0.96820620
125MP0000681_abnormal_thyroid_gland0.95109037
126MP0010368_abnormal_lymphatic_system0.94427832
127MP0001970_abnormal_pain_threshold0.93953035
128MP0001756_abnormal_urination0.93827748
129MP0003868_abnormal_feces_composition0.92954453
130MP0003634_abnormal_glial_cell0.92858326
131MP0001486_abnormal_startle_reflex0.92814729
132MP0005369_muscle_phenotype0.92477315
133MP0002733_abnormal_thermal_nociception0.92392110
134MP0005535_abnormal_body_temperature0.92008466
135MP0003183_abnormal_peptide_metabolism0.89673041
136MP0002452_abnormal_antigen_presenting0.89629853
137MP0000858_altered_metastatic_potential0.87895862
138MP0002971_abnormal_brown_adipose0.87215937
139MP0003123_paternal_imprinting0.87143799
140MP0003828_pulmonary_edema0.87086672
141MP0002398_abnormal_bone_marrow0.85874700
142MP0002234_abnormal_pharynx_morphology0.85337031
143MP0003075_altered_response_to0.85200476
144MP0000703_abnormal_thymus_morphology0.85010721
145MP0004484_altered_response_of0.84910860
146MP0001440_abnormal_grooming_behavior0.84904259
147MP0002877_abnormal_melanocyte_morpholog0.83522064
148MP0000716_abnormal_immune_system0.81754514
149MP0004381_abnormal_hair_follicle0.80883035
150MP0005058_abnormal_lysosome_morphology0.80879569
151MP0000230_abnormal_systemic_arterial0.80801692
152MP0005464_abnormal_platelet_physiology0.80590715
153MP0002089_abnormal_postnatal_growth/wei0.77730467
154MP0003656_abnormal_erythrocyte_physiolo0.77481660
155MP0003633_abnormal_nervous_system0.76683568
156MP0003221_abnormal_cardiomyocyte_apopto0.76148618
157MP0003045_fibrosis0.75403886
158MP0005636_abnormal_mineral_homeostasis0.74984499
159MP0008874_decreased_physiological_sensi0.71640856
160MP0005334_abnormal_fat_pad0.70633808
161MP0003303_peritoneal_inflammation0.70453555
162MP0003566_abnormal_cell_adhesion0.69202753
163MP0005623_abnormal_meninges_morphology0.67570216
164MP0008438_abnormal_cutaneous_collagen0.66738948
165MP0009642_abnormal_blood_homeostasis0.65102049
166MP0005448_abnormal_energy_balance0.64803155
167MP0000598_abnormal_liver_morphology0.64150260
168MP0005165_increased_susceptibility_to0.63226185
169MP0002896_abnormal_bone_mineralization0.60652354
170MP0003953_abnormal_hormone_level0.59921915
171MP0001958_emphysema0.57618049

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.62094454
2Deep venous thrombosis (HP:0002625)4.00338635
3Sudden death (HP:0001699)3.90179127
4Exercise-induced myalgia (HP:0003738)3.71751586
5Ketoacidosis (HP:0001993)3.69737165
6Ketosis (HP:0001946)3.66546892
7Supranuclear gaze palsy (HP:0000605)3.57867254
8Myoglobinuria (HP:0002913)3.55600429
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.53135676
10Xanthomatosis (HP:0000991)3.48975975
11Hypoglycemic coma (HP:0001325)3.26538074
12Exercise-induced muscle cramps (HP:0003710)3.24274987
13Diplopia (HP:0000651)3.23226019
14Abnormality of binocular vision (HP:0011514)3.23226019
15Eczematoid dermatitis (HP:0000976)3.22197753
16Myokymia (HP:0002411)3.20716187
17Ankle clonus (HP:0011448)3.19729921
18Gout (HP:0001997)3.10502057
19Papilledema (HP:0001085)3.08146511
20Hyporeflexia of lower limbs (HP:0002600)3.02835046
21Hyperammonemia (HP:0001987)3.01558678
22Intrahepatic cholestasis (HP:0001406)2.98783308
23Bundle branch block (HP:0011710)2.96077256
24Asymmetric septal hypertrophy (HP:0001670)2.93601567
25Annular pancreas (HP:0001734)2.93546288
26Ventricular tachycardia (HP:0004756)2.91943902
27Neurofibrillary tangles (HP:0002185)2.88651606
28Abnormality of monocarboxylic acid metabolism (HP:0010996)2.85542660
29Right ventricular cardiomyopathy (HP:0011663)2.82467544
30Centrally nucleated skeletal muscle fibers (HP:0003687)2.78371128
31Hyperglycinuria (HP:0003108)2.77241454
32Ventricular fibrillation (HP:0001663)2.72272143
33Distal lower limb muscle weakness (HP:0009053)2.69024551
34Muscle fiber splitting (HP:0003555)2.67453719
35Hyperlipoproteinemia (HP:0010980)2.67011738
36Calf muscle hypertrophy (HP:0008981)2.61993962
37Abnormality of fatty-acid metabolism (HP:0004359)2.60776847
38Abnormality of serine family amino acid metabolism (HP:0010894)2.57472909
39Abnormality of glycine metabolism (HP:0010895)2.57472909
40Abnormality of the nasal mucosa (HP:0000433)2.56809097
41Abnormality of the Achilles tendon (HP:0005109)2.54914753
42Difficulty running (HP:0009046)2.54616069
43Late onset (HP:0003584)2.53421628
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.50896039
45Nasal polyposis (HP:0100582)2.50866087
46Atrioventricular block (HP:0001678)2.50032917
47Cerebral inclusion bodies (HP:0100314)2.49662165
48Increased connective tissue (HP:0009025)2.45985461
49Muscle hypertrophy of the lower extremities (HP:0008968)2.44136432
50Heart block (HP:0012722)2.42338635
51Cellulitis (HP:0100658)2.40490619
52Hypoalphalipoproteinemia (HP:0003233)2.39896046
53Increased IgE level (HP:0003212)2.39490709
54Lymphangioma (HP:0100764)2.38811393
55Complement deficiency (HP:0004431)2.36306197
56Neuronal loss in central nervous system (HP:0002529)2.33659844
57Abnormal atrioventricular conduction (HP:0005150)2.31880993
58Myopathic facies (HP:0002058)2.31451865
59Hyperglycinemia (HP:0002154)2.31427163
60Syncope (HP:0001279)2.31340347
61Distal lower limb amyotrophy (HP:0008944)2.30877023
62Neonatal onset (HP:0003623)2.30807189
63Cholelithiasis (HP:0001081)2.27969106
64Achilles tendon contracture (HP:0001771)2.27634623
65Visual hallucinations (HP:0002367)2.27483169
66Palpitations (HP:0001962)2.26905877
67Ventricular arrhythmia (HP:0004308)2.26868374
68EMG: myopathic abnormalities (HP:0003458)2.25649546
69Hypobetalipoproteinemia (HP:0003563)2.25073224
70Hyperinsulinemic hypoglycemia (HP:0000825)2.24829149
71Skin nodule (HP:0200036)2.24720812
72Abnormality of the calf musculature (HP:0001430)2.22141382
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.20023744
74Rhabdomyolysis (HP:0003201)2.20020589
75Hypolipoproteinemia (HP:0010981)2.16658073
76Lower limb amyotrophy (HP:0007210)2.14942154
77Myotonia (HP:0002486)2.14537646
78Growth hormone excess (HP:0000845)2.13725372
79Abnormality of the left ventricular outflow tract (HP:0011103)2.12882504
80Subaortic stenosis (HP:0001682)2.12882504
81Abnormal gallbladder morphology (HP:0012437)2.12850970
82Increased variability in muscle fiber diameter (HP:0003557)2.12127254
83Spinal canal stenosis (HP:0003416)2.11995033
84Gastrointestinal stroma tumor (HP:0100723)2.11508965
85Abnormality of purine metabolism (HP:0004352)2.11459011
86Prolonged QT interval (HP:0001657)2.11325427
87Atrial fibrillation (HP:0005110)2.10675280
88Foot dorsiflexor weakness (HP:0009027)2.09290672
89Hemiplegia (HP:0002301)2.08369933
90Difficulty climbing stairs (HP:0003551)2.07437197
91Type 1 muscle fiber predominance (HP:0003803)2.07384602
92Muscle stiffness (HP:0003552)2.06773798
93Stridor (HP:0010307)2.06056664
94Slow saccadic eye movements (HP:0000514)2.03266193
95Lipoatrophy (HP:0100578)2.01923446
96Primary atrial arrhythmia (HP:0001692)2.01349442
97Abnormality of the common coagulation pathway (HP:0010990)2.00103949
98Rapidly progressive (HP:0003678)1.98659907
99Action tremor (HP:0002345)1.97797901
100Conjunctival hamartoma (HP:0100780)1.96998952
101Epidermoid cyst (HP:0200040)1.96077915
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95972008
103Dicarboxylic aciduria (HP:0003215)1.95972008
104Truncal ataxia (HP:0002078)1.95877806
105Dysmetric saccades (HP:0000641)1.94797789
106Broad metatarsal (HP:0001783)1.94756538
107Emphysema (HP:0002097)1.94313254
108Spontaneous hematomas (HP:0007420)1.94168736
109Torticollis (HP:0000473)1.93655388
110Hyperacusis (HP:0010780)1.93497269
111Tetraplegia (HP:0002445)1.93088516
112Round ear (HP:0100830)1.92980350
113Polygenic inheritance (HP:0010982)1.91776735
114Polycythemia (HP:0001901)1.91588903
115Abnormality of the foot musculature (HP:0001436)1.91458009
116Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.91047405
117Upper limb amyotrophy (HP:0009129)1.90767913
118Distal upper limb amyotrophy (HP:0007149)1.90767913
119Colitis (HP:0002583)1.90390968
120Broad face (HP:0000283)1.89841621
121Hamartoma of the eye (HP:0010568)1.89703828
122Depression (HP:0000716)1.89616499
123Supraventricular tachycardia (HP:0004755)1.89480934
124Supraventricular arrhythmia (HP:0005115)1.88839940
125Increased purine levels (HP:0004368)1.88164650
126Hyperuricemia (HP:0002149)1.88164650
127Focal motor seizures (HP:0011153)1.88138267
128Delayed CNS myelination (HP:0002188)1.87334163
129Lower limb asymmetry (HP:0100559)1.86746723
130Metabolic acidosis (HP:0001942)1.86457714
131Abnormality of the fingertips (HP:0001211)1.85483389
132Protrusio acetabuli (HP:0003179)1.85410100
133Peripheral hypomyelination (HP:0007182)1.84717726
134Dilated cardiomyopathy (HP:0001644)1.84260751
135Abnormality of skeletal muscle fiber size (HP:0012084)1.84030206
136Abnormality of macrophages (HP:0004311)1.83703779
137Hyperparathyroidism (HP:0000843)1.83608382
138Long toe (HP:0010511)1.82911464
139Abnormality of the lower motor neuron (HP:0002366)1.82548690
140Myositis (HP:0100614)1.82167103
141Cholecystitis (HP:0001082)1.81933415
142Abnormal gallbladder physiology (HP:0012438)1.81933415
143Limb-girdle muscle atrophy (HP:0003797)1.81845107
144EMG: neuropathic changes (HP:0003445)1.81356505
145Sleep apnea (HP:0010535)1.81244014
146Cerebral aneurysm (HP:0004944)1.80576395
147Rigidity (HP:0002063)1.80294199
148Hypercortisolism (HP:0001578)1.79327873
149Segmental peripheral demyelination/remyelination (HP:0003481)1.78542227
150Interstitial pulmonary disease (HP:0006530)1.78522674
151Easy fatigability (HP:0003388)1.78235707
152Abnormal eating behavior (HP:0100738)1.78216081
153Abnormality of sulfur amino acid metabolism (HP:0004339)1.77696646
154Hypoglycemic seizures (HP:0002173)1.77622615
155Epileptic encephalopathy (HP:0200134)1.77269365
156Recurrent abscess formation (HP:0002722)1.76457888
157Hyperglycemia (HP:0003074)1.75957631
158Gastrointestinal inflammation (HP:0004386)1.75869144
159Back pain (HP:0003418)1.75440942
160Axonal loss (HP:0003447)1.75099087
161Turricephaly (HP:0000262)1.71839421
162Mildly elevated creatine phosphokinase (HP:0008180)1.71426275
163Meningitis (HP:0001287)1.70977910
164Postural instability (HP:0002172)1.70855316
165Elevated erythrocyte sedimentation rate (HP:0003565)1.69103240
166Dysostosis multiplex (HP:0000943)1.67868546
167Spastic gait (HP:0002064)1.67717065
168Agammaglobulinemia (HP:0004432)1.67042107
169Focal seizures (HP:0007359)1.67034841
170Shallow orbits (HP:0000586)1.65273617
171Chronic obstructive pulmonary disease (HP:0006510)1.65214155
172Obstructive lung disease (HP:0006536)1.65214155
173Onion bulb formation (HP:0003383)1.65143639
174Recurrent bacterial skin infections (HP:0005406)1.64217659
175Gastrointestinal infarctions (HP:0005244)1.64097208
176Aneurysm (HP:0002617)1.63874648
177Pointed chin (HP:0000307)1.62933890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.18754574
2PRPF4B4.01164145
3PKN23.92134922
4TTN2.91987627
5BCKDK2.82699506
6ERN12.59435105
7RIPK42.59339513
8MAP4K12.33617697
9LMTK22.18326746
10PHKG12.06495915
11PHKG22.06495915
12RIPK12.05573320
13SIK12.00431075
14MAP3K131.85648034
15PTK61.76554340
16KSR21.71628495
17SMG11.65590357
18FGFR41.64523443
19PDGFRA1.55569450
20PRKD31.55451941
21MAP3K71.53780072
22DMPK1.49261567
23TNK21.43801431
24NEK11.42072290
25WNK41.39545458
26TAOK11.37652256
27CAMKK11.34256760
28DAPK21.32271294
29FES1.31324848
30EEF2K1.28611821
31MAP3K101.28054936
32PAK61.26651869
33ZAP701.24603430
34EPHB11.23514655
35ICK1.23435299
36STK381.22470662
37RET1.19738060
38MAP3K91.15855298
39PRKCH1.14804655
40TYK21.13881556
41ARAF1.12225860
42TESK11.11173977
43PINK11.09148537
44PDK31.08781174
45PDK41.08781174
46PAK31.07694624
47NTRK11.07105090
48MAP2K41.05009218
49LRRK21.04671317
50MAP3K21.00034397
51MAP3K10.99951524
52OBSCN0.98557788
53MYLK0.97570382
54PRKD10.97256749
55TAOK20.95499425
56NTRK20.93505841
57PTK20.92060881
58TYRO30.89645592
59BMX0.89485590
60PDPK10.88342603
61CSK0.87010916
62TBK10.86306313
63ILK0.85562451
64DAPK30.83620210
65MARK10.79244970
66SIK30.76338471
67INSRR0.73470420
68BTK0.72357829
69MAPK70.71769300
70JAK20.71161411
71PDK10.70926241
72FGFR30.69982747
73DYRK1B0.69860482
74MAP3K30.69716719
75ALK0.69393325
76CDK120.69188078
77LATS20.68614916
78WNK10.67853419
79CDC42BPA0.67717140
80TAOK30.67589982
81MAP2K30.67076272
82CAMK10.66500978
83FLT30.66361537
84MAPK120.65739777
85PRKD20.64840584
86ITK0.64723531
87GRK50.64384736
88DDR20.63941118
89SYK0.63524577
90SGK2230.63354054
91SGK4940.63354054
92HCK0.62970610
93MAPK110.62389318
94PRKAA10.61762683
95FER0.61370577
96MAP2K20.61115953
97CAMK1G0.60625457
98SGK30.60541054
99MAP3K110.59525542
100BLK0.58082445
101ROCK10.57976419
102JAK10.57269894
103MAP2K10.56270997
104MAPK40.56063493
105FYN0.55802466
106MAPK150.55308228
107STK110.54916962
108UHMK10.53473484
109NTRK30.52998649
110MST1R0.52711960
111JAK30.52073477
112CAMK40.51608912
113PIK3CA0.51541625
114EPHA40.51451566
115IRAK40.50927954
116RPS6KC10.50501383
117RPS6KL10.50501383
118MTOR0.50024870
119EPHB20.48856595
120PTK2B0.48386455
121PRKAA20.48052274
122MINK10.47420572
123CAMK1D0.47349969
124CDK190.47202877
125MARK20.46791984
126GRK60.46418502
127IRAK20.46368697
128MAP2K60.46160558
129PDGFRB0.45767466
130TIE10.45484242
131SCYL20.44833541
132PRKG20.44669235
133CAMK2B0.44324682
134CAMKK20.43594855
135SIK20.43341780
136LCK0.42925685
137MAPKAPK30.42588007
138PRKACG0.42519825
139MAP3K40.40847124
140HIPK20.39963822
141RPS6KA20.39858739
142CDK50.39644156
143PRKCZ0.38483521

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.61135898
2Nitrogen metabolism_Homo sapiens_hsa009103.43212821
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.76298174
4Fatty acid degradation_Homo sapiens_hsa000712.64038752
5Arginine biosynthesis_Homo sapiens_hsa002202.58496140
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.53249722
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.51053138
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32010588
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27340287
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.16487600
11Propanoate metabolism_Homo sapiens_hsa006402.14254251
12Butanoate metabolism_Homo sapiens_hsa006502.10411440
13Long-term potentiation_Homo sapiens_hsa047202.03678278
14Tryptophan metabolism_Homo sapiens_hsa003802.03224613
15Fatty acid metabolism_Homo sapiens_hsa012121.98323621
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75625278
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74958144
18Bile secretion_Homo sapiens_hsa049761.72412436
19PPAR signaling pathway_Homo sapiens_hsa033201.71260886
20B cell receptor signaling pathway_Homo sapiens_hsa046621.60813410
21Carbon metabolism_Homo sapiens_hsa012001.58389887
22Pyruvate metabolism_Homo sapiens_hsa006201.48976990
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43827168
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40023286
25Acute myeloid leukemia_Homo sapiens_hsa052211.36196724
26Amphetamine addiction_Homo sapiens_hsa050311.34821102
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32211363
28Osteoclast differentiation_Homo sapiens_hsa043801.29944482
29Phospholipase D signaling pathway_Homo sapiens_hsa040721.29457246
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.25999113
31T cell receptor signaling pathway_Homo sapiens_hsa046601.25263631
32Fat digestion and absorption_Homo sapiens_hsa049751.21265453
33Starch and sucrose metabolism_Homo sapiens_hsa005001.20780115
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20535181
35Circadian entrainment_Homo sapiens_hsa047131.19844794
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18962914
37Biosynthesis of amino acids_Homo sapiens_hsa012301.18757779
38beta-Alanine metabolism_Homo sapiens_hsa004101.18068776
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17030823
40Peroxisome_Homo sapiens_hsa041461.15726782
41Cholinergic synapse_Homo sapiens_hsa047251.15661298
42Complement and coagulation cascades_Homo sapiens_hsa046101.14968209
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13952563
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12763871
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11825297
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11504190
47Other glycan degradation_Homo sapiens_hsa005111.11281477
48Chronic myeloid leukemia_Homo sapiens_hsa052201.08381184
49Notch signaling pathway_Homo sapiens_hsa043301.07866886
50Morphine addiction_Homo sapiens_hsa050321.07480669
51ErbB signaling pathway_Homo sapiens_hsa040121.05383872
52Dilated cardiomyopathy_Homo sapiens_hsa054141.04226470
53Glutamatergic synapse_Homo sapiens_hsa047241.01400233
54Sulfur metabolism_Homo sapiens_hsa009200.99838835
55Cocaine addiction_Homo sapiens_hsa050300.99330481
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.99104106
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98974555
58Leishmaniasis_Homo sapiens_hsa051400.98248196
59Choline metabolism in cancer_Homo sapiens_hsa052310.97245508
60Lysine degradation_Homo sapiens_hsa003100.95940455
61Renal cell carcinoma_Homo sapiens_hsa052110.95323628
62Endocytosis_Homo sapiens_hsa041440.95163758
63Dopaminergic synapse_Homo sapiens_hsa047280.94839985
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94819630
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94318349
66Insulin resistance_Homo sapiens_hsa049310.94183169
67Endometrial cancer_Homo sapiens_hsa052130.92886827
68Cardiac muscle contraction_Homo sapiens_hsa042600.92581704
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92491902
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92374826
71cAMP signaling pathway_Homo sapiens_hsa040240.92365785
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.92236704
73Chemokine signaling pathway_Homo sapiens_hsa040620.91057580
74Phenylalanine metabolism_Homo sapiens_hsa003600.90692535
75Inositol phosphate metabolism_Homo sapiens_hsa005620.90262457
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88918767
77Primary immunodeficiency_Homo sapiens_hsa053400.86209223
78Nicotine addiction_Homo sapiens_hsa050330.85784479
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84997718
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84743038
81Pancreatic cancer_Homo sapiens_hsa052120.84142685
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83900169
83MAPK signaling pathway_Homo sapiens_hsa040100.83666436
84Calcium signaling pathway_Homo sapiens_hsa040200.83358557
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.82171901
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81835975
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.81562285
88Melanogenesis_Homo sapiens_hsa049160.79684529
89Autoimmune thyroid disease_Homo sapiens_hsa053200.79652950
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.77768224
91Tuberculosis_Homo sapiens_hsa051520.77500215
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76837942
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.76806619
94Rap1 signaling pathway_Homo sapiens_hsa040150.75850004
95Caffeine metabolism_Homo sapiens_hsa002320.75469507
96Glucagon signaling pathway_Homo sapiens_hsa049220.75419354
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74556336
98Viral myocarditis_Homo sapiens_hsa054160.74350802
99Allograft rejection_Homo sapiens_hsa053300.73956151
100Glycerolipid metabolism_Homo sapiens_hsa005610.73432483
101Graft-versus-host disease_Homo sapiens_hsa053320.72898614
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72884383
103Insulin signaling pathway_Homo sapiens_hsa049100.72737163
104Toxoplasmosis_Homo sapiens_hsa051450.72669739
105Type II diabetes mellitus_Homo sapiens_hsa049300.72630600
106Platelet activation_Homo sapiens_hsa046110.72596421
107Prolactin signaling pathway_Homo sapiens_hsa049170.72086304
108Histidine metabolism_Homo sapiens_hsa003400.71642452
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69534385
110ABC transporters_Homo sapiens_hsa020100.68807718
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68644600
112Chemical carcinogenesis_Homo sapiens_hsa052040.67729353
113Arginine and proline metabolism_Homo sapiens_hsa003300.67383822
114Tyrosine metabolism_Homo sapiens_hsa003500.66709391
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66230507
116Insulin secretion_Homo sapiens_hsa049110.65623171
117Fatty acid biosynthesis_Homo sapiens_hsa000610.65261507
118Selenocompound metabolism_Homo sapiens_hsa004500.64828761
119Hepatitis C_Homo sapiens_hsa051600.64700575
120Long-term depression_Homo sapiens_hsa047300.64519306
121Gastric acid secretion_Homo sapiens_hsa049710.64368018
122Fatty acid elongation_Homo sapiens_hsa000620.64268008
123Ras signaling pathway_Homo sapiens_hsa040140.63912856
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63035650
125Sulfur relay system_Homo sapiens_hsa041220.62497688
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62009653
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61522715
128Gap junction_Homo sapiens_hsa045400.61178737
129AMPK signaling pathway_Homo sapiens_hsa041520.59962544
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58670841
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.58419771
132TNF signaling pathway_Homo sapiens_hsa046680.57416274
133Type I diabetes mellitus_Homo sapiens_hsa049400.56683958
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.53663020
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50310339
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.49361704
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47640481
138Galactose metabolism_Homo sapiens_hsa000520.46588006
139Staphylococcus aureus infection_Homo sapiens_hsa051500.46069181
140Pancreatic secretion_Homo sapiens_hsa049720.45948526
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44722431
142Prion diseases_Homo sapiens_hsa050200.44141263
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41574188
144Thyroid hormone synthesis_Homo sapiens_hsa049180.40832687
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39944282
146VEGF signaling pathway_Homo sapiens_hsa043700.38294501
147mTOR signaling pathway_Homo sapiens_hsa041500.37723702
148Fructose and mannose metabolism_Homo sapiens_hsa000510.37723561
149Bladder cancer_Homo sapiens_hsa052190.36790378
150Estrogen signaling pathway_Homo sapiens_hsa049150.35667926
151Drug metabolism - other enzymes_Homo sapiens_hsa009830.34599854
152Retinol metabolism_Homo sapiens_hsa008300.34363784
153Renin secretion_Homo sapiens_hsa049240.33746001
154Salivary secretion_Homo sapiens_hsa049700.33732725
155Oxytocin signaling pathway_Homo sapiens_hsa049210.33512631
156Glioma_Homo sapiens_hsa052140.33152631
157Protein digestion and absorption_Homo sapiens_hsa049740.32591362
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32099850
159GABAergic synapse_Homo sapiens_hsa047270.31000011
160Focal adhesion_Homo sapiens_hsa045100.30768315
161GnRH signaling pathway_Homo sapiens_hsa049120.30487552
162Pentose phosphate pathway_Homo sapiens_hsa000300.30120914
163Amoebiasis_Homo sapiens_hsa051460.27472796
164Synaptic vesicle cycle_Homo sapiens_hsa047210.26428624
165Non-small cell lung cancer_Homo sapiens_hsa052230.25597359

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