AFAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)5.02328950
2cell adhesion mediated by integrin (GO:0033627)4.59481806
3pyrimidine nucleobase catabolic process (GO:0006208)4.55993816
4skin morphogenesis (GO:0043589)4.29610301
5metanephric mesenchyme development (GO:0072075)4.12348520
6endodermal cell differentiation (GO:0035987)4.07466681
7substrate-dependent cell migration (GO:0006929)3.98556188
8kidney mesenchyme development (GO:0072074)3.81359689
9sympathetic nervous system development (GO:0048485)3.77925816
10negative regulation of axon guidance (GO:1902668)3.72392882
11cerebral cortex radially oriented cell migration (GO:0021799)3.59687096
12cell migration involved in sprouting angiogenesis (GO:0002042)3.54912730
13retina vasculature morphogenesis in camera-type eye (GO:0061299)3.50491907
14negative regulation of chondrocyte differentiation (GO:0032331)3.47946566
15sequestering of extracellular ligand from receptor (GO:0035581)3.46664233
16cardiac ventricle formation (GO:0003211)3.44832385
17negative regulation of axon extension involved in axon guidance (GO:0048843)3.44344475
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.44324367
19central nervous system projection neuron axonogenesis (GO:0021952)3.42807906
20spinal cord development (GO:0021510)3.38531008
21cardiac chamber formation (GO:0003207)3.38152946
22axon extension involved in axon guidance (GO:0048846)3.37603277
23neuron projection extension involved in neuron projection guidance (GO:1902284)3.37603277
24paraxial mesoderm development (GO:0048339)3.37012653
25wound healing, spreading of epidermal cells (GO:0035313)3.32019020
26nucleobase catabolic process (GO:0046113)3.31717945
27ganglion development (GO:0061548)3.28478700
28cell-substrate junction assembly (GO:0007044)3.28110887
29hemidesmosome assembly (GO:0031581)3.24803267
30actin filament depolymerization (GO:0030042)3.24294028
31basement membrane organization (GO:0071711)3.23147825
32positive regulation of blood vessel endothelial cell migration (GO:0043536)3.21414400
33extracellular fibril organization (GO:0043206)3.20480279
34glomerulus development (GO:0032835)3.19993680
35axonal fasciculation (GO:0007413)3.15950084
36cell migration involved in heart development (GO:0060973)3.14452644
37Golgi transport vesicle coating (GO:0048200)3.14263401
38COPI coating of Golgi vesicle (GO:0048205)3.14263401
39regulation of axon guidance (GO:1902667)3.14002553
40neuron recognition (GO:0008038)3.13968568
41cell migration in hindbrain (GO:0021535)3.12977681
42endothelial cell morphogenesis (GO:0001886)3.08569619
43chondrocyte proliferation (GO:0035988)3.07242913
44collagen metabolic process (GO:0032963)3.01362104
45protein retention in ER lumen (GO:0006621)2.97520005
46positive regulation of osteoblast proliferation (GO:0033690)2.97263906
47planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96713726
48cytoskeletal anchoring at plasma membrane (GO:0007016)2.96014231
49axon extension (GO:0048675)2.94088128
50facial nerve structural organization (GO:0021612)2.93923374
51semaphorin-plexin signaling pathway (GO:0071526)2.93792186
52mesodermal cell differentiation (GO:0048333)2.93350189
53substrate adhesion-dependent cell spreading (GO:0034446)2.90905816
54vascular endothelial growth factor signaling pathway (GO:0038084)2.90626034
55adherens junction assembly (GO:0034333)2.90509111
56heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.90112542
57regulation of axon extension involved in axon guidance (GO:0048841)2.89388131
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88522146
59protein localization to endosome (GO:0036010)2.87291112
60dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.85236983
61type B pancreatic cell proliferation (GO:0044342)2.85169551
62wound healing, spreading of cells (GO:0044319)2.84856870
63collagen catabolic process (GO:0030574)2.82962778
64regulation of transforming growth factor beta2 production (GO:0032909)2.82722002
65cornea development in camera-type eye (GO:0061303)2.81831801
66multicellular organismal macromolecule metabolic process (GO:0044259)2.80461601
67negative chemotaxis (GO:0050919)2.80332958
68cranial nerve structural organization (GO:0021604)2.79393084
69neuron cell-cell adhesion (GO:0007158)2.79106210
70regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.78585243
71lymphangiogenesis (GO:0001946)2.78450460
72epithelial cell-cell adhesion (GO:0090136)2.74529953
73pericardium development (GO:0060039)2.74413353
74dendrite morphogenesis (GO:0048813)2.73894304
75atrial septum morphogenesis (GO:0060413)2.73843588
76glial cell proliferation (GO:0014009)2.73159366
77positive regulation of axon extension (GO:0045773)2.72510220
78regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.72412810
79retinal ganglion cell axon guidance (GO:0031290)2.71615055
80endocardial cushion development (GO:0003197)2.71608298
81central nervous system neuron axonogenesis (GO:0021955)2.71346232
82postsynaptic membrane organization (GO:0001941)2.71240854
83neural crest cell development (GO:0014032)2.69525332
84generation of neurons (GO:0048699)2.69470636
85vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.68270152
86extracellular matrix assembly (GO:0085029)2.68091309
87cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.67967394
88cerebral cortex cell migration (GO:0021795)2.67952631
89negative regulation of fatty acid transport (GO:2000192)2.65466202
90focal adhesion assembly (GO:0048041)2.64053190
91cell-substrate adherens junction assembly (GO:0007045)2.64053190
92barbed-end actin filament capping (GO:0051016)2.64038294
93extracellular matrix disassembly (GO:0022617)2.63652864
94cranial nerve morphogenesis (GO:0021602)2.63170608
95multicellular organismal metabolic process (GO:0044236)2.62570543
96blood vessel endothelial cell migration (GO:0043534)2.61857950
97fibril organization (GO:0097435)2.61367212
98regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59676248
99stress fiber assembly (GO:0043149)2.58500411
100extracellular regulation of signal transduction (GO:1900115)2.58111515
101extracellular negative regulation of signal transduction (GO:1900116)2.58111515
102glomerular basement membrane development (GO:0032836)2.57841387
103cardiac right ventricle morphogenesis (GO:0003215)2.57809941
104negative regulation of smooth muscle cell migration (GO:0014912)2.57005125
105calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.56703795
106positive regulation of cartilage development (GO:0061036)2.56149676
107multicellular organismal catabolic process (GO:0044243)2.55601891
108cell differentiation involved in kidney development (GO:0061005)2.54616233
109chondrocyte development (GO:0002063)2.54593330
110positive regulation of male gonad development (GO:2000020)2.53797509
111mesonephros development (GO:0001823)2.52860503
112venous blood vessel morphogenesis (GO:0048845)2.52357951
113negative regulation of cartilage development (GO:0061037)2.52232857
114urinary tract smooth muscle contraction (GO:0014848)2.52181927
115response to pheromone (GO:0019236)2.51324064
116negative regulation of stem cell proliferation (GO:2000647)2.51135010
117anatomical structure arrangement (GO:0048532)2.50905637
118sprouting angiogenesis (GO:0002040)2.50786925
119olfactory bulb development (GO:0021772)2.50219033
120extracellular matrix organization (GO:0030198)2.49525538
121mesenchymal-epithelial cell signaling (GO:0060638)2.49156893
122outer ear morphogenesis (GO:0042473)2.49049415
123Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.48681866
124dermatan sulfate metabolic process (GO:0030205)2.48676861
125extracellular structure organization (GO:0043062)2.48583921
126regulation of chondrocyte differentiation (GO:0032330)2.47971725
127regulation of cartilage development (GO:0061035)2.47533642
128presynaptic membrane assembly (GO:0097105)2.47530755
129positive regulation of synapse assembly (GO:0051965)2.47304457
130mesenchymal cell differentiation involved in renal system development (GO:2001012)2.47111365
131mesenchymal cell differentiation involved in kidney development (GO:0072161)2.47111365
132collagen fibril organization (GO:0030199)2.46653312
133hippocampus development (GO:0021766)2.46254848
134bone trabecula formation (GO:0060346)2.45348245
135cochlea morphogenesis (GO:0090103)2.44125666
136positive regulation of endothelial cell migration (GO:0010595)2.43885205
137cellular response to vitamin (GO:0071295)2.43846719
138hippo signaling (GO:0035329)2.43582055
139positive regulation of endothelial cell apoptotic process (GO:2000353)2.43503451
140heparan sulfate proteoglycan metabolic process (GO:0030201)2.42418507
141myoblast fusion (GO:0007520)2.40590726
142neuron projection extension (GO:1990138)2.39766331
143vocalization behavior (GO:0071625)2.39750704
144regulation of establishment of planar polarity (GO:0090175)2.39735479
145positive regulation of fibroblast migration (GO:0010763)2.39655647
146kidney morphogenesis (GO:0060993)2.39571692
147dendritic spine morphogenesis (GO:0060997)2.38800814
148eyelid development in camera-type eye (GO:0061029)2.37774122
149layer formation in cerebral cortex (GO:0021819)2.37700253
150regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.37425453
151substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.36597355
152substrate-independent telencephalic tangential migration (GO:0021826)2.36597355
153somite development (GO:0061053)2.36542883
154apical protein localization (GO:0045176)2.35568882
155camera-type eye morphogenesis (GO:0048593)2.35245151
156ventricular septum morphogenesis (GO:0060412)2.35031720
157proximal/distal pattern formation (GO:0009954)2.34502236
158protein heterotrimerization (GO:0070208)2.33637414
159presynaptic membrane organization (GO:0097090)2.33513734
160dermatan sulfate biosynthetic process (GO:0030208)2.33044827
161negative regulation of axon extension (GO:0030517)2.32979116
162lateral sprouting from an epithelium (GO:0060601)2.32039079
163dentate gyrus development (GO:0021542)2.32008989
164negative regulation of keratinocyte proliferation (GO:0010839)2.31971237
165neuron migration (GO:0001764)2.31400702
166lens morphogenesis in camera-type eye (GO:0002089)2.31282092
167mesenchymal cell development (GO:0014031)2.31266373
168positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.28554659
169regulation of non-canonical Wnt signaling pathway (GO:2000050)2.27353268
170regulation of synapse assembly (GO:0051963)2.26987506
171homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.26429566
172regulation of male gonad development (GO:2000018)2.25179601
173cardiac myofibril assembly (GO:0055003)2.24597143
174negative regulation of chemotaxis (GO:0050922)2.24204584
175atrial cardiac muscle cell action potential (GO:0086014)2.22502993
176protein localization to microtubule (GO:0035372)2.22048669
177cardiac septum morphogenesis (GO:0060411)2.21883151
178retina layer formation (GO:0010842)2.21046579
179regulation of glycogen (starch) synthase activity (GO:2000465)2.20962247

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.04599851
2GBX2_23144817_ChIP-Seq_PC3_Human3.53664787
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.35948644
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.20989176
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13074932
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.73933378
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.66079820
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.48562612
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46068300
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39768667
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39768667
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39528349
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38412674
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35376523
15* BRD4_25478319_ChIP-Seq_HGPS_Human2.28918126
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.23730818
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.22211794
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16679224
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16384295
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.14189662
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08235262
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07091583
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.05551371
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.01025257
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99373587
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.98084328
27CLOCK_20551151_ChIP-Seq_293T_Human1.95848183
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93922756
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92290196
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.91010061
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.87407498
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79916974
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79293040
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79116334
35AR_21572438_ChIP-Seq_LNCaP_Human1.75401553
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.74859552
37RNF2_27304074_Chip-Seq_NSC_Mouse1.72485695
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72427865
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69963647
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.69442385
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.67321155
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66139859
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.65526081
44* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.64265325
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64191511
46* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63488965
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63343110
48TAF15_26573619_Chip-Seq_HEK293_Human1.62542037
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62205168
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61735066
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.58442412
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.56914069
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55960541
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55027234
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54259190
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53920620
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53920620
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.53734357
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52499575
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.51953370
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51664745
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51448937
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51275285
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49911173
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49376262
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48788608
67* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48611519
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47602199
69IGF1R_20145208_ChIP-Seq_DFB_Human1.46440384
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.46022987
71* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45845589
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45406064
73* P300_19829295_ChIP-Seq_ESCs_Human1.44856468
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44833872
75AHR_22903824_ChIP-Seq_MCF-7_Human1.43772377
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43362209
77* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42984896
78TP53_22127205_ChIP-Seq_IMR90_Human1.42615065
79* SMAD4_21799915_ChIP-Seq_A2780_Human1.41826528
80FUS_26573619_Chip-Seq_HEK293_Human1.41761703
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40537472
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40537472
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40506903
84* SMAD3_21741376_ChIP-Seq_EPCs_Human1.40027155
85* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38699473
86* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38556061
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38204263
88TP53_23651856_ChIP-Seq_MEFs_Mouse1.37208800
89ER_23166858_ChIP-Seq_MCF-7_Human1.37019860
90* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36992156
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.36249036
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35530466
93* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33336521
94TP53_18474530_ChIP-ChIP_U2OS_Human1.33127366
95KDM2B_26808549_Chip-Seq_K562_Human1.31582872
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30780776
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29467643
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29222771
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28714022
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28714022
101UBF1/2_26484160_Chip-Seq_HMECs_Human1.28489546
102TP53_16413492_ChIP-PET_HCT116_Human1.28398253
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28203645
104* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27375829
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27350623
106TP53_20018659_ChIP-ChIP_R1E_Mouse1.26041899
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.25436280
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24783069
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24736499
110ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24118554
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24078675
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23898997
113* DROSHA_22980978_ChIP-Seq_HELA_Human1.22221636
114* ISL1_27105846_Chip-Seq_CPCs_Mouse1.21261465
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21228967
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20793284
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.18808028
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17248403
119* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17191226
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16214411
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15796391
122* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15569199
123* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14050595
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.12775732
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12458634
126SOX9_26525672_Chip-Seq_HEART_Mouse1.12429460
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11816677
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11698564
129STAT3_23295773_ChIP-Seq_U87_Human1.11254797
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09776616
131TCF4_18268006_ChIP-ChIP_LS174T_Human1.09748474
132* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08538423
133BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08293891
134AR_25329375_ChIP-Seq_VCAP_Human1.08048197
135EWS_26573619_Chip-Seq_HEK293_Human1.07792963
136* TCF4_23295773_ChIP-Seq_U87_Human1.07630969
137TET1_21490601_ChIP-Seq_MESCs_Mouse1.07043556
138* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06519905
139* CJUN_26792858_Chip-Seq_BT549_Human1.06513351
140TBX20_22328084_ChIP-Seq_HEART_Mouse1.06502409
141TBX20_22080862_ChIP-Seq_HEART_Mouse1.06502409
142POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06017937
143REST_21632747_ChIP-Seq_MESCs_Mouse1.05865291
144ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05475018
145* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05425297
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04892380
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04503088
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03958102
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03485317
150AR_19668381_ChIP-Seq_PC3_Human1.03017965
151* RUNX2_22187159_ChIP-Seq_PCA_Human1.02636313
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02600498
153PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02263108
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01511115
155SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00371074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.23361502
2MP0008438_abnormal_cutaneous_collagen3.12715394
3MP0003566_abnormal_cell_adhesion2.98073170
4MP0005503_abnormal_tendon_morphology2.76624088
5MP0003385_abnormal_body_wall2.52379810
6MP0000778_abnormal_nervous_system2.25536054
7MP0008789_abnormal_olfactory_epithelium2.24217377
8MP0003787_abnormal_imprinting2.21601594
9MP0003091_abnormal_cell_migration2.14607448
10MP0003122_maternal_imprinting2.10704008
11MP0001188_hyperpigmentation2.05180125
12MP0005623_abnormal_meninges_morphology2.00327011
13MP0009250_abnormal_appendicular_skeleto1.96478148
14MP0010030_abnormal_orbit_morphology1.93691746
15MP0003942_abnormal_urinary_system1.88193383
16MP0003121_genomic_imprinting1.86248505
17MP0000767_abnormal_smooth_muscle1.80131636
18MP0005275_abnormal_skin_tensile1.79196569
19MP0000516_abnormal_urinary_system1.74822274
20MP0005367_renal/urinary_system_phenotyp1.74822274
21MP0000049_abnormal_middle_ear1.74042652
22MP0005023_abnormal_wound_healing1.73798288
23MP0001984_abnormal_olfaction1.72950995
24MP0005394_taste/olfaction_phenotype1.72663905
25MP0005499_abnormal_olfactory_system1.72663905
26MP0005248_abnormal_Harderian_gland1.68684419
27MP0004134_abnormal_chest_morphology1.68314208
28MP0004272_abnormal_basement_membrane1.67471753
29MP0002877_abnormal_melanocyte_morpholog1.66486514
30MP0010352_gastrointestinal_tract_polyps1.62061189
31MP0001299_abnormal_eye_distance/1.59055129
32MP0000534_abnormal_ureter_morphology1.58278973
33MP0001542_abnormal_bone_strength1.53591445
34MP0002060_abnormal_skin_morphology1.52869154
35MP0006054_spinal_hemorrhage1.52826713
36MP0002184_abnormal_innervation1.51837735
37MP0003755_abnormal_palate_morphology1.51639790
38MP0000733_abnormal_muscle_development1.50284271
39MP0001348_abnormal_lacrimal_gland1.49316285
40MP0002233_abnormal_nose_morphology1.46709360
41MP0000751_myopathy1.44801281
42MP0005171_absent_coat_pigmentation1.40855396
43MP0003279_aneurysm1.40047075
44MP0000537_abnormal_urethra_morphology1.32226581
45MP0000566_synostosis1.31418887
46MP0001177_atelectasis1.31219804
47MP0002751_abnormal_autonomic_nervous1.30827093
48MP0003941_abnormal_skin_development1.30034942
49MP0001879_abnormal_lymphatic_vessel1.29135274
50MP0002295_abnormal_pulmonary_circulatio1.28657931
51MP0000631_abnormal_neuroendocrine_gland1.27714983
52MP0002249_abnormal_larynx_morphology1.24936582
53MP0002116_abnormal_craniofacial_bone1.22390410
54MP0002938_white_spotting1.21964000
55MP0006276_abnormal_autonomic_nervous1.21534001
56MP0001958_emphysema1.20802823
57MP0009384_cardiac_valve_regurgitation1.20794978
58MP0000003_abnormal_adipose_tissue1.20588652
59MP0005197_abnormal_uvea_morphology1.16469597
60MP0002108_abnormal_muscle_morphology1.16235835
61MP0003115_abnormal_respiratory_system1.15697743
62MP0005508_abnormal_skeleton_morphology1.15121336
63MP0003937_abnormal_limbs/digits/tail_de1.14119107
64MP0003861_abnormal_nervous_system1.13664917
65MP0005595_abnormal_vascular_smooth1.11877054
66MP0003935_abnormal_craniofacial_develop1.10725651
67MP0001849_ear_inflammation1.07439770
68MP0002282_abnormal_trachea_morphology1.07008453
69MP0004859_abnormal_synaptic_plasticity1.06065883
70MP0010368_abnormal_lymphatic_system1.05665022
71MP0005257_abnormal_intraocular_pressure1.05016902
72MP0002063_abnormal_learning/memory/cond1.04468541
73MP0001243_abnormal_dermal_layer1.04145310
74MP0004133_heterotaxia1.04003535
75MP0009053_abnormal_anal_canal1.03756782
76MP0004270_analgesia1.03590811
77MP0002234_abnormal_pharynx_morphology1.03111576
78MP0003635_abnormal_synaptic_transmissio1.02732610
79MP0002734_abnormal_mechanical_nocicepti1.02424816
80MP0000569_abnormal_digit_pigmentation1.02394079
81MP0009780_abnormal_chondrocyte_physiolo1.02203519
82MP0001486_abnormal_startle_reflex1.01277448
83MP0002932_abnormal_joint_morphology0.98386661
84MP0005423_abnormal_somatic_nervous0.98296394
85MP0003938_abnormal_ear_development0.98055362
86MP0000759_abnormal_skeletal_muscle0.97764587
87MP0002152_abnormal_brain_morphology0.97475087
88MP0000428_abnormal_craniofacial_morphol0.97272553
89MP0009046_muscle_twitch0.96793859
90MP0000955_abnormal_spinal_cord0.96034665
91MP0002882_abnormal_neuron_morphology0.95263527
92MP0002752_abnormal_somatic_nervous0.95190876
93MP0000462_abnormal_digestive_system0.93967164
94MP0003950_abnormal_plasma_membrane0.93887845
95MP0002177_abnormal_outer_ear0.92031971
96MP0006292_abnormal_olfactory_placode0.90456064
97MP0003880_abnormal_central_pattern0.89684296
98MP0002081_perinatal_lethality0.88727229
99MP0002114_abnormal_axial_skeleton0.88704734
100MP0002557_abnormal_social/conspecific_i0.88690501
101MP0002735_abnormal_chemical_nociception0.87917563
102MP0000762_abnormal_tongue_morphology0.87649788
103MP0000026_abnormal_inner_ear0.87087297
104MP0000749_muscle_degeneration0.86284466
105MP0004811_abnormal_neuron_physiology0.85509607
106MP0001286_abnormal_eye_development0.85266123
107MP0005409_darkened_coat_color0.84327801
108MP0002102_abnormal_ear_morphology0.84128094
109MP0006138_congestive_heart_failure0.83785737
110MP0004215_abnormal_myocardial_fiber0.83452699
111MP0002128_abnormal_blood_circulation0.82905901
112MP0005645_abnormal_hypothalamus_physiol0.82720614
113MP0003137_abnormal_impulse_conducting0.82697900
114MP0000432_abnormal_head_morphology0.82463336
115MP0001915_intracranial_hemorrhage0.82320305
116MP0002109_abnormal_limb_morphology0.82073279
117MP0001614_abnormal_blood_vessel0.82016303
118MP0005076_abnormal_cell_differentiation0.82013407
119MP0000163_abnormal_cartilage_morphology0.81419081
120MP0001346_abnormal_lacrimal_gland0.81125039
121MP0003119_abnormal_digestive_system0.80384381
122MP0004084_abnormal_cardiac_muscle0.80233168
123MP0002697_abnormal_eye_size0.79896424
124MP0010386_abnormal_urinary_bladder0.79803182
125MP0004233_abnormal_muscle_weight0.79760923
126MP0002572_abnormal_emotion/affect_behav0.78931093
127MP0002925_abnormal_cardiovascular_devel0.78536234
128MP0002896_abnormal_bone_mineralization0.77825881
129MP0005620_abnormal_muscle_contractility0.76922494
130MP0000013_abnormal_adipose_tissue0.76343217
131MP0004858_abnormal_nervous_system0.75963382
132MP0000538_abnormal_urinary_bladder0.68451349
133MP0000750_abnormal_muscle_regeneration0.68207122
134MP0005193_abnormal_anterior_eye0.68099789
135MP0002113_abnormal_skeleton_development0.66112640
136MP0002115_abnormal_skeleton_extremities0.65679117
137MP0002092_abnormal_eye_morphology0.64417701
138MP0004087_abnormal_muscle_fiber0.64378778
139MP0000467_abnormal_esophagus_morphology0.64192592
140MP0003283_abnormal_digestive_organ0.58354106
141MP0005187_abnormal_penis_morphology0.58014069
142MP0002168_other_aberrant_phenotype0.57921940
143MP0005621_abnormal_cell_physiology0.56872529
144MP0005390_skeleton_phenotype0.56460524
145MP0001175_abnormal_lung_morphology0.55846265
146MP0001340_abnormal_eyelid_morphology0.55558197

Predicted human phenotypes

RankGene SetZ-score
1Arterial tortuosity (HP:0005116)4.29087331
2Ankle contracture (HP:0006466)3.72998039
3Fragile skin (HP:0001030)3.51297894
4Hepatoblastoma (HP:0002884)3.28388089
5Genu recurvatum (HP:0002816)3.22008066
6Neonatal short-limb short stature (HP:0008921)3.08973941
7Mitral valve prolapse (HP:0001634)3.07190648
8Shallow orbits (HP:0000586)2.91292232
9Premature rupture of membranes (HP:0001788)2.89910255
10Cervical subluxation (HP:0003308)2.89288021
11Bowel diverticulosis (HP:0005222)2.83635658
12Cerebral aneurysm (HP:0004944)2.83488889
13Blue sclerae (HP:0000592)2.78140487
14Spondylolisthesis (HP:0003302)2.76701847
15Morphological abnormality of the middle ear (HP:0008609)2.74379946
16Peritonitis (HP:0002586)2.73030704
17Dilatation of the ascending aorta (HP:0005111)2.70297420
18Bell-shaped thorax (HP:0001591)2.69791542
19Aortic regurgitation (HP:0001659)2.64682449
20Wrist flexion contracture (HP:0001239)2.63428528
21Short nail (HP:0001799)2.54614651
22Mitral regurgitation (HP:0001653)2.54054767
23Ulnar bowing (HP:0003031)2.52590450
24Protrusio acetabuli (HP:0003179)2.46641708
25Asymmetry of the thorax (HP:0001555)2.44518248
26Abnormality of dentin (HP:0010299)2.44166748
27Septo-optic dysplasia (HP:0100842)2.38809299
28Mildly elevated creatine phosphokinase (HP:0008180)2.33264798
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.32481964
30Short 4th metacarpal (HP:0010044)2.32481964
31Overgrowth (HP:0001548)2.32291930
32Biconcave vertebral bodies (HP:0004586)2.32284546
33Hyperacusis (HP:0010780)2.31217569
34Abnormal hair whorl (HP:0010721)2.29476291
35Elbow flexion contracture (HP:0002987)2.27637718
36Upper limb amyotrophy (HP:0009129)2.25856428
37Distal upper limb amyotrophy (HP:0007149)2.25856428
38Febrile seizures (HP:0002373)2.23914497
39Atrophic scars (HP:0001075)2.23844553
40Mild short stature (HP:0003502)2.19729317
41Papillary thyroid carcinoma (HP:0002895)2.18749713
42Vertebral compression fractures (HP:0002953)2.18481511
43Gait imbalance (HP:0002141)2.17319395
44Neoplasm of the adrenal cortex (HP:0100641)2.16959325
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.16891581
46Osteolytic defects of the hand bones (HP:0009699)2.16891581
47Disproportionate tall stature (HP:0001519)2.16460185
48Aortic dissection (HP:0002647)2.16179582
49Slender build (HP:0001533)2.15339245
50Abnormal delivery (HP:0001787)2.12778748
51Increased variability in muscle fiber diameter (HP:0003557)2.12103366
52Mitral stenosis (HP:0001718)2.11804995
53Abnormality of the acetabulum (HP:0003170)2.11279946
54Broad face (HP:0000283)2.11145648
55Aneurysm (HP:0002617)2.10895680
56Distal lower limb amyotrophy (HP:0008944)2.08871301
57Abnormality of the nasal septum (HP:0000419)2.02697059
58Ectopia lentis (HP:0001083)1.98703389
59Round ear (HP:0100830)1.98180844
60Hypoplastic left heart (HP:0004383)1.97579572
61Broad metatarsal (HP:0001783)1.97333086
62Narrow nasal bridge (HP:0000446)1.95851060
63Tibial bowing (HP:0002982)1.95392381
64Bladder diverticulum (HP:0000015)1.94802501
65Lower limb amyotrophy (HP:0007210)1.94147086
66Lissencephaly (HP:0001339)1.93653081
67Natal tooth (HP:0000695)1.91687973
68Nephrogenic diabetes insipidus (HP:0009806)1.91611645
69Hallux valgus (HP:0001822)1.90642385
70Soft skin (HP:0000977)1.90640537
71Aortic valve stenosis (HP:0001650)1.90482662
72Increased connective tissue (HP:0009025)1.89949865
73Adrenal hypoplasia (HP:0000835)1.89375834
74Subacute progressive viral hepatitis (HP:0006572)1.89244782
75Breech presentation (HP:0001623)1.88989075
76Aplasia/Hypoplasia of the lens (HP:0008063)1.88362702
77Deviation of the hallux (HP:0010051)1.88043812
78Renal hypoplasia (HP:0000089)1.87525386
79Absent frontal sinuses (HP:0002688)1.86604135
80Hand muscle atrophy (HP:0009130)1.86258672
81Hypoplasia of the iris (HP:0007676)1.85577086
82Curly hair (HP:0002212)1.83244299
83Bowing of the arm (HP:0006488)1.81543035
84Bowed forearm bones (HP:0003956)1.81543035
85Myelomeningocele (HP:0002475)1.79777760
86Medial flaring of the eyebrow (HP:0010747)1.78896706
87Hypoplastic heart (HP:0001961)1.77635638
88Camptodactyly of toe (HP:0001836)1.77521123
89Optic nerve hypoplasia (HP:0000609)1.77053433
90Omphalocele (HP:0001539)1.76944820
91Abnormality of incisor morphology (HP:0011063)1.76788520
92Long toe (HP:0010511)1.76601026
93Vertebral arch anomaly (HP:0008438)1.76256601
94Abnormality of skeletal muscle fiber size (HP:0012084)1.75903647
95Protruding ear (HP:0000411)1.74710367
96Inguinal hernia (HP:0000023)1.74101176
97Broad ribs (HP:0000885)1.74065892
98Genital tract atresia (HP:0001827)1.72892562
99Abnormality of the intervertebral disk (HP:0005108)1.72879239
100Difficulty climbing stairs (HP:0003551)1.72795415
101Infantile muscular hypotonia (HP:0008947)1.72481696
102Knee flexion contracture (HP:0006380)1.72219366
103Vaginal atresia (HP:0000148)1.71787669
104Osteoarthritis (HP:0002758)1.71777826
105Limb-girdle muscle weakness (HP:0003325)1.71403694
106Congenital primary aphakia (HP:0007707)1.71002866
107Renovascular hypertension (HP:0100817)1.70889446
108Syringomyelia (HP:0003396)1.70539377
109Spinal cord lesions (HP:0100561)1.70539377
110Abnormality of the 4th metacarpal (HP:0010012)1.70531047
111Limb dystonia (HP:0002451)1.69969656
112Intellectual disability, moderate (HP:0002342)1.69947225
113Insomnia (HP:0100785)1.68298539
114Cutaneous finger syndactyly (HP:0010554)1.67599506
115Thin bony cortex (HP:0002753)1.65423284
116Abnormality of the calcaneus (HP:0008364)1.65281585
117Abnormality of the septum pellucidum (HP:0007375)1.65208134
118Wormian bones (HP:0002645)1.65019466
119Congenital glaucoma (HP:0001087)1.64857612
120Absent eyebrow (HP:0002223)1.64771619
121Coronal craniosynostosis (HP:0004440)1.64765769
122Venous abnormality (HP:0002624)1.64730887
123Absent septum pellucidum (HP:0001331)1.64627809
124Mesomelia (HP:0003027)1.64486264
125Abnormality of the nasolacrimal system (HP:0000614)1.64387982
126Bradycardia (HP:0001662)1.64207096
127Achilles tendon contracture (HP:0001771)1.63937832
128Keratoconus (HP:0000563)1.63932092
129Increased corneal curvature (HP:0100692)1.63932092
130Midline defect of the nose (HP:0004122)1.63748459
131Aplasia/Hypoplasia of the brainstem (HP:0007362)1.63630240
132Hypoplasia of the brainstem (HP:0002365)1.63630240
133Radial bowing (HP:0002986)1.62879751
134High anterior hairline (HP:0009890)1.61853823
135Atrioventricular canal defect (HP:0006695)1.61283863
136Abnormality of the aortic arch (HP:0012303)1.60868654
137Striae distensae (HP:0001065)1.60826075
138Spinal rigidity (HP:0003306)1.60672904
139Fibular hypoplasia (HP:0003038)1.60442709
140Deep philtrum (HP:0002002)1.60440134
141Follicular hyperkeratosis (HP:0007502)1.59892210
142Atonic seizures (HP:0010819)1.58110378
143Buphthalmos (HP:0000557)1.57416748
144Embryonal renal neoplasm (HP:0011794)1.57301353
145True hermaphroditism (HP:0010459)1.57301031
146Volvulus (HP:0002580)1.56446688
147Abnormality of the calf musculature (HP:0001430)1.56388284
148Aortic aneurysm (HP:0004942)1.56243576
149Joint laxity (HP:0001388)1.55156834
150Type 1 muscle fiber predominance (HP:0003803)1.53748646
151Epileptic encephalopathy (HP:0200134)1.53061568
152Exotropia (HP:0000577)1.52755193
153Renal duplication (HP:0000075)1.52407038
154Renal dysplasia (HP:0000110)1.51300364
155Wide anterior fontanel (HP:0000260)1.50604304
156Vascular tortuosity (HP:0004948)1.49634105
157Flat cornea (HP:0007720)1.49056463
158Stomach cancer (HP:0012126)1.48893594
159Central scotoma (HP:0000603)1.48126419
160Pachygyria (HP:0001302)1.47986809
161Hypoventilation (HP:0002791)1.47594655
162Nephroblastoma (Wilms tumor) (HP:0002667)1.47144915
163Anophthalmia (HP:0000528)1.46836568
164Hyperextensible skin (HP:0000974)1.46577387
165Abnormality of the lacrimal duct (HP:0011481)1.45730206
166Occipital encephalocele (HP:0002085)1.45147578
167Focal motor seizures (HP:0011153)1.44433067
168Progressive sensorineural hearing impairment (HP:0000408)1.44061110
169Advanced eruption of teeth (HP:0006288)1.44019977
170Germ cell neoplasia (HP:0100728)1.43338295
171Neoplasm of the adrenal gland (HP:0100631)1.43288981
172Poor coordination (HP:0002370)1.43090169
173Vesicoureteral reflux (HP:0000076)1.42674958
174Atrial fibrillation (HP:0005110)1.42586534
175Submucous cleft hard palate (HP:0000176)1.42108905
176Aqueductal stenosis (HP:0002410)1.41973088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.72119315
2CASK4.12435812
3ERBB33.94732476
4NTRK13.67425713
5PTK23.10860743
6AKT32.94955903
7PRPF4B2.61410451
8DYRK22.59167781
9MET2.49925392
10MAPK132.42665252
11TRIB32.24040863
12EPHB22.18985415
13MST1R2.02057526
14EPHA22.02036671
15PLK21.98562222
16RIPK11.87185986
17SGK21.84332629
18LMTK21.83573308
19LIMK11.78565983
20YES11.70891742
21MAP2K71.68484862
22LATS11.64807081
23NEK91.63937100
24STK381.59179397
25ZAK1.56893738
26SGK4941.55748951
27SGK2231.55748951
28DDR21.55454559
29PHKG21.53839776
30PHKG11.53839776
31TGFBR21.51155053
32MKNK11.50776546
33NTRK21.50528114
34PAK41.49689288
35MAP3K41.46263443
36PDGFRB1.39952051
37EPHB11.37284101
38LATS21.37007157
39BCR1.32021613
40MKNK21.31513270
41CDK121.27946754
42EPHA31.25704723
43TIE11.25571117
44PKN11.24030399
45CDK81.21809912
46PKN21.20431131
47PAK31.14802433
48FLT31.12682878
49BMPR1B1.12417207
50PRKD21.10710631
51PIK3CA1.09582822
52SGK31.08603504
53* MTOR1.08240674
54EIF2AK21.07590872
55MAP3K61.06439907
56MYLK1.06392278
57CAMK1G1.06304224
58MINK11.05754537
59ILK1.04422684
60SIK31.04259693
61ROCK11.03187050
62SRPK11.01793478
63PLK31.01673372
64ICK1.00873897
65FER1.00190797
66MOS0.99726420
67PRKCE0.98912512
68INSRR0.97414622
69STK38L0.96666399
70FRK0.96105988
71WNK30.94115387
72CSNK1A1L0.91585615
73ROCK20.91302135
74TRPM70.83104674
75DYRK1A0.82848092
76CAMK1D0.82704220
77TTN0.82065568
78SIK10.80491887
79RPS6KA20.80029176
80TESK10.79857620
81PIM20.77738399
82PLK40.77031997
83PTK2B0.76820972
84PNCK0.75589663
85BMPR20.73636532
86NTRK30.72938345
87CSNK1G30.72761333
88PRKG20.72571296
89CSNK1G20.71864143
90FGFR20.70652507
91DMPK0.67109334
92CDC42BPA0.66997161
93PAK60.65706511
94NUAK10.62879327
95EEF2K0.62763609
96KSR10.61961868
97OBSCN0.59779541
98MAP3K70.56165022
99MARK20.56071111
100CSNK1G10.55804447
101UHMK10.54531721
102CDK30.53977588
103CDK50.53721301
104BMX0.53720877
105SIK20.53180116
106STK30.52845798
107CAMK40.52216495
108ABL20.51875241
109ERN10.51643495
110MELK0.51358763
111GSK3A0.50899415
112DAPK30.50364598
113NEK60.49236514
114CDK140.49179189
115RPS6KB10.49153429
116CAMK2G0.48759437
117PRKCG0.48497402
118WNK10.48344451
119CDK180.48022435
120ERBB40.47706109
121CAMK2A0.47360768
122FGFR10.47235570
123MAP3K100.46797038
124MAPK90.46641476
125ADRBK10.46103050
126CAMK2B0.45768582
127STK240.45388287
128PDGFRA0.44567305
129DYRK1B0.43931492
130PIK3CG0.43704732
131BRAF0.43542985
132CAMK2D0.43496478
133PDK40.43354862
134PDK30.43354862
135TESK20.43335330
136RET0.43091074
137MAP2K10.42983374
138PRKG10.42859284
139PRKD30.41965396
140CDK150.41641079
141CLK10.41288616
142CDK90.40451544
143TYRO30.39604961
144SCYL20.38514479
145MAPK80.38458876
146IRAK30.38327374
147PRKCZ0.38191891
148PAK10.38079623
149SGK10.37608473
150PRKD10.37567217
151CDK11A0.36691328
152PAK20.36337328
153* SRC0.32194021
154ARAF0.32124319
155PTK60.31327806
156NEK20.30263622

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.48263638
2Nicotine addiction_Homo sapiens_hsa050332.47427724
3Basal cell carcinoma_Homo sapiens_hsa052171.89687837
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84073318
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82962942
6Dilated cardiomyopathy_Homo sapiens_hsa054141.81928896
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74248898
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.73658546
9Endometrial cancer_Homo sapiens_hsa052131.73447456
10Hippo signaling pathway_Homo sapiens_hsa043901.66368432
11ECM-receptor interaction_Homo sapiens_hsa045121.64577649
12GABAergic synapse_Homo sapiens_hsa047271.64270364
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63908981
14Morphine addiction_Homo sapiens_hsa050321.61583509
15Hedgehog signaling pathway_Homo sapiens_hsa043401.59985073
16Synaptic vesicle cycle_Homo sapiens_hsa047211.51902824
17Colorectal cancer_Homo sapiens_hsa052101.51316224
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45273446
19Focal adhesion_Homo sapiens_hsa045101.45150520
20Melanoma_Homo sapiens_hsa052181.43282878
21Circadian entrainment_Homo sapiens_hsa047131.42970776
22Adherens junction_Homo sapiens_hsa045201.41690201
23Wnt signaling pathway_Homo sapiens_hsa043101.41504763
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41182993
25Olfactory transduction_Homo sapiens_hsa047401.32572912
26Cholinergic synapse_Homo sapiens_hsa047251.29015167
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.28378598
28Bladder cancer_Homo sapiens_hsa052191.27915417
29Taste transduction_Homo sapiens_hsa047421.27543131
30Serotonergic synapse_Homo sapiens_hsa047261.26779192
31Dopaminergic synapse_Homo sapiens_hsa047281.23886358
32TGF-beta signaling pathway_Homo sapiens_hsa043501.22818896
33ErbB signaling pathway_Homo sapiens_hsa040121.22400276
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18889465
35Gap junction_Homo sapiens_hsa045401.18774252
36MicroRNAs in cancer_Homo sapiens_hsa052061.17900297
37Glutamatergic synapse_Homo sapiens_hsa047241.17359870
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15312958
39Tight junction_Homo sapiens_hsa045301.10701258
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09020082
41Renal cell carcinoma_Homo sapiens_hsa052111.09000194
42Viral myocarditis_Homo sapiens_hsa054161.08118046
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07556916
44Melanogenesis_Homo sapiens_hsa049161.05904242
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05736267
46Vibrio cholerae infection_Homo sapiens_hsa051101.04353277
47Glioma_Homo sapiens_hsa052141.03419512
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02869917
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02308294
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00533807
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.99795799
52Cocaine addiction_Homo sapiens_hsa050300.98761675
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.98309610
54Pathways in cancer_Homo sapiens_hsa052000.97373334
55Prostate cancer_Homo sapiens_hsa052150.95418843
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94603116
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94273285
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94151258
59Proteoglycans in cancer_Homo sapiens_hsa052050.94150095
60Endocytosis_Homo sapiens_hsa041440.93787744
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.92280012
62Collecting duct acid secretion_Homo sapiens_hsa049660.91666483
63Ras signaling pathway_Homo sapiens_hsa040140.91148296
64Thyroid cancer_Homo sapiens_hsa052160.89964971
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89889140
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89579512
67Phagosome_Homo sapiens_hsa041450.89215658
68Long-term depression_Homo sapiens_hsa047300.88648681
69Renin secretion_Homo sapiens_hsa049240.88594658
70Phototransduction_Homo sapiens_hsa047440.87168039
71Rap1 signaling pathway_Homo sapiens_hsa040150.86497464
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83413953
73Platelet activation_Homo sapiens_hsa046110.82004869
74Pancreatic cancer_Homo sapiens_hsa052120.80915683
75Notch signaling pathway_Homo sapiens_hsa043300.80223122
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79323043
77Prion diseases_Homo sapiens_hsa050200.78900033
78Cardiac muscle contraction_Homo sapiens_hsa042600.77897900
79Chronic myeloid leukemia_Homo sapiens_hsa052200.77130635
80Insulin secretion_Homo sapiens_hsa049110.76422490
81MAPK signaling pathway_Homo sapiens_hsa040100.74314677
82Shigellosis_Homo sapiens_hsa051310.74072072
83Oxytocin signaling pathway_Homo sapiens_hsa049210.73220825
84Estrogen signaling pathway_Homo sapiens_hsa049150.73164904
85cAMP signaling pathway_Homo sapiens_hsa040240.72330768
86Ovarian steroidogenesis_Homo sapiens_hsa049130.71088183
87AMPK signaling pathway_Homo sapiens_hsa041520.70780055
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70727789
89Amoebiasis_Homo sapiens_hsa051460.69277986
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.68268562
91Small cell lung cancer_Homo sapiens_hsa052220.68169660
92GnRH signaling pathway_Homo sapiens_hsa049120.67503850
93mTOR signaling pathway_Homo sapiens_hsa041500.67203227
94Dorso-ventral axis formation_Homo sapiens_hsa043200.66895201
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66139467
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65380876
97VEGF signaling pathway_Homo sapiens_hsa043700.65289185
98FoxO signaling pathway_Homo sapiens_hsa040680.65178149
99Thyroid hormone synthesis_Homo sapiens_hsa049180.64013530
100Amphetamine addiction_Homo sapiens_hsa050310.63466259
101Calcium signaling pathway_Homo sapiens_hsa040200.62839819
102Salmonella infection_Homo sapiens_hsa051320.62205216
103Long-term potentiation_Homo sapiens_hsa047200.61353312
104Choline metabolism in cancer_Homo sapiens_hsa052310.61336061
105Non-small cell lung cancer_Homo sapiens_hsa052230.60933648
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60090035
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.58674230
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58527886
109Gastric acid secretion_Homo sapiens_hsa049710.56896167
110Alcoholism_Homo sapiens_hsa050340.56748999
111mRNA surveillance pathway_Homo sapiens_hsa030150.55036728
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54872331
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54860593
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54673445
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53927216
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53769022
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52731976
118Prolactin signaling pathway_Homo sapiens_hsa049170.52530286
119Salivary secretion_Homo sapiens_hsa049700.51901926
120Inositol phosphate metabolism_Homo sapiens_hsa005620.51226053
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50635121
122Protein digestion and absorption_Homo sapiens_hsa049740.49766529
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49283557
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49136268
125Insulin signaling pathway_Homo sapiens_hsa049100.47720968
126Lysine degradation_Homo sapiens_hsa003100.47396024
127N-Glycan biosynthesis_Homo sapiens_hsa005100.47319327
128Glucagon signaling pathway_Homo sapiens_hsa049220.45625670

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