AFAP1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.03711369
2daunorubicin metabolic process (GO:0044597)7.00686551
3polyketide metabolic process (GO:0030638)7.00686551
4doxorubicin metabolic process (GO:0044598)7.00686551
5cardiac myofibril assembly (GO:0055003)5.84473431
6negative regulation of potassium ion transmembrane transport (GO:1901380)5.81459397
7sarcomere organization (GO:0045214)5.79778748
8myofibril assembly (GO:0030239)5.36868881
9sprouting angiogenesis (GO:0002040)5.31144986
10negative regulation of blood vessel endothelial cell migration (GO:0043537)5.13838635
11Notch signaling involved in heart development (GO:0061314)5.01013160
12aminoglycoside antibiotic metabolic process (GO:0030647)4.98651981
13actin-myosin filament sliding (GO:0033275)4.97733147
14muscle filament sliding (GO:0030049)4.97733147
15positive regulation of vasculogenesis (GO:2001214)4.93647295
16regulation of sarcomere organization (GO:0060297)4.79811002
17blood vessel maturation (GO:0001955)4.76853043
18ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.74374934
19surfactant homeostasis (GO:0043129)4.64584494
20cardiac muscle tissue morphogenesis (GO:0055008)4.55423051
21endothelium development (GO:0003158)4.53836420
22heart trabecula formation (GO:0060347)4.49796396
23lymph vessel development (GO:0001945)4.45878043
24angiogenesis involved in wound healing (GO:0060055)4.44178262
25cardiac muscle cell development (GO:0055013)4.29103001
26regulation of actin filament-based movement (GO:1903115)4.23263347
27vascular endothelial growth factor signaling pathway (GO:0038084)4.16963819
28regulation of vasculogenesis (GO:2001212)4.14820786
29phagocytosis, recognition (GO:0006910)4.13497361
30cytidine metabolic process (GO:0046087)4.08073769
31cytidine catabolic process (GO:0006216)4.08073769
32cytidine deamination (GO:0009972)4.08073769
33muscle tissue morphogenesis (GO:0060415)4.08058335
34cardiac cell development (GO:0055006)4.05419772
35regulation of response to osmotic stress (GO:0047484)4.03245131
36actin-mediated cell contraction (GO:0070252)4.00241480
37negative regulation of endothelial cell migration (GO:0010596)3.96973661
38regulation of relaxation of muscle (GO:1901077)3.96483181
39wound healing, spreading of epidermal cells (GO:0035313)3.93097679
40patterning of blood vessels (GO:0001569)3.89914709
41actomyosin structure organization (GO:0031032)3.87273906
42cardiac muscle contraction (GO:0060048)3.86865907
43endothelial cell differentiation (GO:0045446)3.85111637
44maintenance of protein location in nucleus (GO:0051457)3.84819572
45skeletal muscle contraction (GO:0003009)3.78463073
46cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.77455981
47glomerular filtration (GO:0003094)3.71533851
48morphogenesis of an endothelium (GO:0003159)3.69543960
49endothelial tube morphogenesis (GO:0061154)3.69543960
50endothelial cell morphogenesis (GO:0001886)3.62036619
51positive regulation of odontogenesis (GO:0042482)3.60534697
52regulation of cardioblast differentiation (GO:0051890)3.60166107
53negative regulation of epidermis development (GO:0045683)3.59051413
54regulation of endothelial cell differentiation (GO:0045601)3.57721155
55establishment of endothelial barrier (GO:0061028)3.55473242
56chemical homeostasis within a tissue (GO:0048875)3.55454286
57venous blood vessel morphogenesis (GO:0048845)3.52327235
58plasma membrane repair (GO:0001778)3.50489667
59regulation of blood vessel endothelial cell migration (GO:0043535)3.45690444
60sarcoplasmic reticulum calcium ion transport (GO:0070296)3.45080620
61trabecula formation (GO:0060343)3.45067560
62adult heart development (GO:0007512)3.43965224
63regulation of skeletal muscle contraction (GO:0014819)3.40825976
64heart valve formation (GO:0003188)3.40161725
65cell migration involved in sprouting angiogenesis (GO:0002042)3.38823552
66embryonic heart tube development (GO:0035050)3.37210255
67bundle of His cell to Purkinje myocyte communication (GO:0086069)3.37189766
68renal filtration (GO:0097205)3.35360790
69lymphangiogenesis (GO:0001946)3.33483831
70cardiac muscle hypertrophy (GO:0003300)3.31976891
71positive regulation of endothelial cell differentiation (GO:0045603)3.29708267
72striated muscle contraction (GO:0006941)3.28448023
73cardiac muscle cell proliferation (GO:0060038)3.28086149
74negative regulation of potassium ion transport (GO:0043267)3.27692389
75ventricular trabecula myocardium morphogenesis (GO:0003222)3.27103880
76hormone catabolic process (GO:0042447)3.23391469
77negative regulation of protein localization to cell surface (GO:2000009)3.22775599
78muscle organ morphogenesis (GO:0048644)3.22065507
79gap junction assembly (GO:0016264)3.19409600
80regulation of vascular permeability (GO:0043114)3.18547812
81heart process (GO:0003015)3.14796232
82heart contraction (GO:0060047)3.14796232
83striated muscle hypertrophy (GO:0014897)3.12565498
84regulation of cardiac muscle cell contraction (GO:0086004)3.12051466
85regulation of striated muscle contraction (GO:0006942)3.10879382
86pyrimidine ribonucleoside catabolic process (GO:0046133)3.10654847
87regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.09910994
88regulation of the force of heart contraction (GO:0002026)3.09870117
89regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.09501346
90negative regulation of cell cycle G2/M phase transition (GO:1902750)3.08801696
91heart trabecula morphogenesis (GO:0061384)3.08028407
92quinone metabolic process (GO:1901661)3.07736150
93tricarboxylic acid cycle (GO:0006099)3.07635012
94negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.07525797
95somite rostral/caudal axis specification (GO:0032525)3.04490285
96positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.02502165
97negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.02235810
98response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.01351160
99blood vessel endothelial cell migration (GO:0043534)3.00126169
100substrate-dependent cell migration (GO:0006929)2.96793834
101regulation of endothelial cell migration (GO:0010594)2.95916141
102actin filament-based movement (GO:0030048)2.95870242
103basement membrane organization (GO:0071711)2.95545396
104endothelial cell proliferation (GO:0001935)2.95441249
105regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.95294669
106negative regulation of epithelial cell migration (GO:0010633)2.95267027
107response to muscle activity (GO:0014850)2.93228454
108trabecula morphogenesis (GO:0061383)2.93178783
109endodermal cell differentiation (GO:0035987)2.92555832
110regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.92431007
111ventricular cardiac muscle cell action potential (GO:0086005)2.91560029
112calcium-mediated signaling using intracellular calcium source (GO:0035584)2.89400010
113mitochondrion distribution (GO:0048311)2.87166293
114cellular response to osmotic stress (GO:0071470)2.85592201
115negative regulation of interleukin-2 production (GO:0032703)2.85579908
116angiogenesis (GO:0001525)2.84717063
117negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.81756465
118plasma membrane fusion (GO:0045026)2.81738506
119regulation of mammary gland epithelial cell proliferation (GO:0033599)2.81599423
120positive regulation of protein deacetylation (GO:0090312)2.79022510
121response to inactivity (GO:0014854)2.78965020
122artery development (GO:0060840)2.78892095
123muscle contraction (GO:0006936)2.78505807
124cell-substrate junction assembly (GO:0007044)2.78027521
125vasculogenesis (GO:0001570)2.77867965
126negative regulation of epidermal cell differentiation (GO:0045605)2.77699906
127regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.77698482
128retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77345758
129megakaryocyte development (GO:0035855)2.76329975
130vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76281412
131cellular hyperosmotic response (GO:0071474)2.75519900
132biotin metabolic process (GO:0006768)2.74926690
133mRNA transcription from RNA polymerase II promoter (GO:0042789)2.74036316
134regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.71782297
135cell adhesion mediated by integrin (GO:0033627)2.71439429
136negative regulation of angiogenesis (GO:0016525)2.71393570
137coronary vasculature morphogenesis (GO:0060977)2.71384004
138blood vessel remodeling (GO:0001974)2.70281322
139myoblast fusion (GO:0007520)2.70002960
140substrate adhesion-dependent cell spreading (GO:0034446)2.69068763
141labyrinthine layer development (GO:0060711)2.69021783
142blood vessel morphogenesis (GO:0048514)2.69000365
143cell migration involved in heart development (GO:0060973)2.68405473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.62335719
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.77438596
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.77438596
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.77438596
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64847921
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.42343394
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.07443765
8* SCL_19346495_ChIP-Seq_HPC-7_Human2.91458040
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.77225155
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74593845
11* GATA2_21666600_ChIP-Seq_HMVEC_Human2.70028922
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.44569924
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.37678669
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.36751505
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.30497548
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29461254
17GATA1_22025678_ChIP-Seq_K562_Human2.25671156
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.23378779
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.18657099
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.12022679
21SALL4_18804426_ChIP-ChIP_XEN_Mouse2.11034918
22SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.07858195
23ESR1_20079471_ChIP-ChIP_T-47D_Human2.04441168
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.98513832
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94960668
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94383950
27* TBX20_22328084_ChIP-Seq_HEART_Mouse1.92785902
28* TBX20_22080862_ChIP-Seq_HEART_Mouse1.92785902
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.90131394
30* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86195926
31CJUN_26792858_Chip-Seq_BT549_Human1.85966766
32NFIB_24661679_ChIP-Seq_LUNG_Mouse1.85289663
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.82333696
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.82317974
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.71487869
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69968322
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.69360703
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69234793
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.67284803
40TCF3_18692474_ChIP-Seq_MESCs_Mouse1.65524980
41BRD4_25478319_ChIP-Seq_HGPS_Human1.63169180
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62061414
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52775937
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52199596
45PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.49258563
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48664814
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48632892
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48632892
49TCF7_22412390_ChIP-Seq_EML_Mouse1.47738385
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46196236
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45317898
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.44999526
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.44643012
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37841999
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37262986
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37001535
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34951260
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34951260
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34118196
60GATA1_19941826_ChIP-Seq_K562_Human1.32943824
61NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.32604850
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.29322021
63NCOR1_26117541_ChIP-Seq_K562_Human1.29282261
64SMC3_22415368_ChIP-Seq_MEFs_Mouse1.28599023
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28588333
66RACK7_27058665_Chip-Seq_MCF-7_Human1.27428884
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.27027263
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26910861
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26500308
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26468345
71SPI1_23127762_ChIP-Seq_K562_Human1.24461259
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21784631
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21729334
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19784223
75EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19536709
76RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19536709
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19366905
78UBF1/2_26484160_Chip-Seq_HMECs_Human1.17366478
79PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.16357715
80GATA4_21415370_ChIP-Seq_HL-1_Mouse1.16200611
81NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15744652
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15397813
83NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15352897
84ZNF263_19887448_ChIP-Seq_K562_Human1.15208251
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14938833
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14888003
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12441601
88NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.12366492
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09609159
90SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09458223
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08806916
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07534140
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07244585
94* TP53_23651856_ChIP-Seq_MEFs_Mouse1.06868547
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.06663289
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06490539
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05794255
98LXR_22292898_ChIP-Seq_THP-1_Human1.05603926
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.05495114
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05032702
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03177926
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.02166541
103* TP53_22127205_ChIP-Seq_IMR90_Human1.01893710
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00479568
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99696921
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99039259
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98949876
108WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98835354
109TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97708041
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97379334
111PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.97097196
112KDM2B_26808549_Chip-Seq_K562_Human0.96083735
113EED_16625203_ChIP-ChIP_MESCs_Mouse0.95543051
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95224998
115NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94551258
116KDM2B_26808549_Chip-Seq_DND41_Human0.94078771
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94066653
118E2F1_17053090_ChIP-ChIP_MCF-7_Human0.93854393
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.93769555
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93577603
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93557338
122LXR_22158963_ChIP-Seq_LIVER_Mouse0.93389380
123TP63_23658742_ChIP-Seq_EP156T_Human0.92750731
124MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92296663
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91862900
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91467015
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91403616
128SA1_22415368_ChIP-Seq_MEFs_Mouse0.91033144
129ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89964499
130* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89755340
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89723451
132IRF1_19129219_ChIP-ChIP_H3396_Human0.87557854
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87360980
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86589993
135SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85714926
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85428038
137OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84334374
138* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84194024
139SOX2_20726797_ChIP-Seq_SW620_Human0.83895917
140TP63_22573176_ChIP-Seq_HFKS_Human0.83628672
141TCF4_18268006_ChIP-ChIP_LS174T_Human0.83217224
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83103195
143CSB_26484114_Chip-Seq_FIBROBLAST_Human0.82848947
144GATA2_19941826_ChIP-Seq_K562_Human0.82504935
145SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81782636
146* CTCF_21964334_Chip-Seq_Bcells_Human0.81305023
147CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81271460
148LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80718145
149EOMES_21245162_ChIP-Seq_HESCs_Human0.80297486
150GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79827303
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.79658130
152VDR_21846776_ChIP-Seq_THP-1_Human0.79296446
153SPI1_20517297_ChIP-Seq_HL60_Human0.78365714
154PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77880547
155NFI_21473784_ChIP-Seq_ESCs_Mouse0.77337643
156TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77091895
157STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.76842763
158MYC_22102868_ChIP-Seq_BL_Human0.76284184
159* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.76228638
160ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74324238
161P68_20966046_ChIP-Seq_HELA_Human0.72998448
162CLOCK_20551151_ChIP-Seq_293T_Human0.72913192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.36281207
2MP0004084_abnormal_cardiac_muscle4.95206118
3MP0005167_abnormal_blood-brain_barrier3.52832306
4MP0001879_abnormal_lymphatic_vessel3.49706267
5MP0004215_abnormal_myocardial_fiber3.43365613
6MP0004036_abnormal_muscle_relaxation3.34873213
7MP0000749_muscle_degeneration3.21305166
8MP0003828_pulmonary_edema3.21044669
9MP0005330_cardiomyopathy3.06426188
10MP0002837_dystrophic_cardiac_calcinosis2.94737324
11MP0000751_myopathy2.84393539
12MP0008438_abnormal_cutaneous_collagen2.72655358
13MP0004272_abnormal_basement_membrane2.60689955
14MP0002332_abnormal_exercise_endurance2.51361614
15MP0006138_congestive_heart_failure2.51116924
16MP0002972_abnormal_cardiac_muscle2.45224654
17MP0010630_abnormal_cardiac_muscle2.42504713
18MP0000013_abnormal_adipose_tissue2.42489862
19MP0002127_abnormal_cardiovascular_syste2.40856905
20MP0003950_abnormal_plasma_membrane2.36708215
21MP0008775_abnormal_heart_ventricle2.35616693
22MP0004087_abnormal_muscle_fiber2.20539027
23MP0003137_abnormal_impulse_conducting2.15812729
24MP0001544_abnormal_cardiovascular_syste2.14880818
25MP0005385_cardiovascular_system_phenoty2.14880818
26MP0000750_abnormal_muscle_regeneration2.08458831
27MP0004484_altered_response_of2.06856559
28MP0005620_abnormal_muscle_contractility1.99051287
29MP0003646_muscle_fatigue1.96460127
30MP0004085_abnormal_heartbeat1.95902066
31MP0003122_maternal_imprinting1.94786832
32MP0000343_altered_response_to1.84158809
33MP0002106_abnormal_muscle_physiology1.78031600
34MP0004264_abnormal_extraembryonic_tissu1.66932879
35MP0003221_abnormal_cardiomyocyte_apopto1.64386295
36MP0000003_abnormal_adipose_tissue1.63083990
37MP0004233_abnormal_muscle_weight1.61430221
38MP0004147_increased_porphyrin_level1.61251061
39MP0004145_abnormal_muscle_electrophysio1.60395818
40MP0005275_abnormal_skin_tensile1.51634236
41MP0003011_delayed_dark_adaptation1.49770550
42MP0000767_abnormal_smooth_muscle1.47080136
43MP0002269_muscular_atrophy1.46984363
44MP0005369_muscle_phenotype1.45399304
45MP0002396_abnormal_hematopoietic_system1.42723149
46MP0002925_abnormal_cardiovascular_devel1.42684200
47MP0000759_abnormal_skeletal_muscle1.42073361
48MP0005075_abnormal_melanosome_morpholog1.41298860
49MP0002877_abnormal_melanocyte_morpholog1.37054620
50MP0003567_abnormal_fetal_cardiomyocyte1.36402717
51MP0005165_increased_susceptibility_to1.35246974
52MP0006036_abnormal_mitochondrial_physio1.33571086
53MP0005623_abnormal_meninges_morphology1.32531177
54MP0005409_darkened_coat_color1.30325074
55MP0004782_abnormal_surfactant_physiolog1.30163586
56MP0003279_aneurysm1.29534905
57MP0000266_abnormal_heart_morphology1.29090246
58MP0002128_abnormal_blood_circulation1.24522098
59MP0005375_adipose_tissue_phenotype1.22505924
60MP0003984_embryonic_growth_retardation1.21483575
61MP0005451_abnormal_body_composition1.20394076
62MP0002088_abnormal_embryonic_growth/wei1.20074753
63MP0000747_muscle_weakness1.17641533
64MP0003091_abnormal_cell_migration1.12605255
65MP0000249_abnormal_blood_vessel1.11510347
66MP0003705_abnormal_hypodermis_morpholog1.09667576
67MP0001614_abnormal_blood_vessel1.08840996
68MP0003941_abnormal_skin_development1.08569154
69MP0006035_abnormal_mitochondrial_morpho1.08230120
70MP0002254_reproductive_system_inflammat1.07983596
71MP0004130_abnormal_muscle_cell1.07376339
72MP0001915_intracranial_hemorrhage1.06599389
73MP0003566_abnormal_cell_adhesion1.00104123
74MP0001672_abnormal_embryogenesis/_devel0.99638640
75MP0005380_embryogenesis_phenotype0.99638640
76MP0008961_abnormal_basal_metabolism0.98182246
77MP0010030_abnormal_orbit_morphology0.95742671
78MP0004858_abnormal_nervous_system0.94713231
79MP0005266_abnormal_metabolism0.92694551
80MP0003724_increased_susceptibility_to0.91834532
81MP0001958_emphysema0.91457307
82MP0001661_extended_life_span0.90568648
83MP0006054_spinal_hemorrhage0.88881018
84MP0002933_joint_inflammation0.87338412
85MP0005023_abnormal_wound_healing0.87088003
86MP0002138_abnormal_hepatobiliary_system0.86704583
87MP0004043_abnormal_pH_regulation0.85374861
88MP0002086_abnormal_extraembryonic_tissu0.84646384
89MP0003121_genomic_imprinting0.83815648
90MP0009053_abnormal_anal_canal0.80164604
91MP0000465_gastrointestinal_hemorrhage0.79829071
92MP0001784_abnormal_fluid_regulation0.79487397
93MP0004808_abnormal_hematopoietic_stem0.78007422
94MP0000762_abnormal_tongue_morphology0.76106618
95MP0004883_abnormal_blood_vessel0.70811209
96MP0001849_ear_inflammation0.70780127
97MP0006292_abnormal_olfactory_placode0.70408040
98MP0000733_abnormal_muscle_development0.69264165
99MP0005503_abnormal_tendon_morphology0.66968145
100MP0002971_abnormal_brown_adipose0.65775753
101MP0005187_abnormal_penis_morphology0.65497517
102MP0002896_abnormal_bone_mineralization0.64782958
103MP0005257_abnormal_intraocular_pressure0.64673318
104MP0000230_abnormal_systemic_arterial0.63808481
105MP0002295_abnormal_pulmonary_circulatio0.63701164
106MP0009278_abnormal_bone_marrow0.62527835
107MP0000467_abnormal_esophagus_morphology0.61500391
108MP0005670_abnormal_white_adipose0.61482612
109MP0003385_abnormal_body_wall0.61282249
110MP0003943_abnormal_hepatobiliary_system0.60288840
111MP0004510_myositis0.57992579
112MP0003935_abnormal_craniofacial_develop0.57789894
113MP0003123_paternal_imprinting0.57744993
114MP0005666_abnormal_adipose_tissue0.57534889
115MP0003890_abnormal_embryonic-extraembry0.55974096
116MP0005595_abnormal_vascular_smooth0.55119366
117MP0003191_abnormal_cellular_cholesterol0.54954336
118MP0005388_respiratory_system_phenotype0.54444473
119MP0002133_abnormal_respiratory_system0.54444473
120MP0009697_abnormal_copulation0.53898263
121MP0002108_abnormal_muscle_morphology0.52123811
122MP0002932_abnormal_joint_morphology0.49674402
123MP0001545_abnormal_hematopoietic_system0.49177824
124MP0005397_hematopoietic_system_phenotyp0.49177824
125MP0005164_abnormal_response_to0.48962275
126MP0005193_abnormal_anterior_eye0.48489703
127MP0001299_abnormal_eye_distance/0.48365142
128MP0002060_abnormal_skin_morphology0.48177688
129MP0000920_abnormal_myelination0.48140602
130MP0000537_abnormal_urethra_morphology0.47508714

Predicted human phenotypes

RankGene SetZ-score
1Ventricular tachycardia (HP:0004756)6.12054110
2Sudden death (HP:0001699)5.62980809
3Exercise-induced muscle cramps (HP:0003710)5.40096703
4Distal arthrogryposis (HP:0005684)5.30247654
5Muscle fiber splitting (HP:0003555)4.86781360
6Atrial fibrillation (HP:0005110)4.82387522
7Difficulty running (HP:0009046)4.73915631
8Round ear (HP:0100830)4.71179958
9Primary atrial arrhythmia (HP:0001692)4.48630430
10Supraventricular arrhythmia (HP:0005115)4.41416407
11Supraventricular tachycardia (HP:0004755)4.38625071
12Increased connective tissue (HP:0009025)4.26566581
13Subaortic stenosis (HP:0001682)4.16011595
14Abnormality of the left ventricular outflow tract (HP:0011103)4.16011595
15Ragged-red muscle fibers (HP:0003200)4.15435100
16Ulnar deviation of the wrist (HP:0003049)4.14909218
17Bilateral microphthalmos (HP:0007633)4.12068723
18Calf muscle hypertrophy (HP:0008981)4.11580350
19Popliteal pterygium (HP:0009756)3.94042925
20EMG: myopathic abnormalities (HP:0003458)3.93090592
21Lipoatrophy (HP:0100578)3.88368858
22Exercise-induced myalgia (HP:0003738)3.86178539
23Hyporeflexia of lower limbs (HP:0002600)3.86033383
24Muscle hypertrophy of the lower extremities (HP:0008968)3.85552034
25Multiple enchondromatosis (HP:0005701)3.74623923
26Protrusio acetabuli (HP:0003179)3.70716206
27Cerebral aneurysm (HP:0004944)3.62249804
28Malignant hyperthermia (HP:0002047)3.59640182
29Dilated cardiomyopathy (HP:0001644)3.54479379
30Abnormality of the calf musculature (HP:0001430)3.54405129
31Hypochromic microcytic anemia (HP:0004840)3.38396582
32Premature rupture of membranes (HP:0001788)3.26111862
33Spinal rigidity (HP:0003306)3.25854769
34Polycythemia (HP:0001901)3.25092955
35Abnormality of the nasal mucosa (HP:0000433)3.17531802
36Spontaneous hematomas (HP:0007420)3.15407116
37Calcaneovalgus deformity (HP:0001848)3.08480183
38Abnormality of the salivary glands (HP:0010286)3.06683714
39Myotonia (HP:0002486)3.05488525
40Amniotic constriction ring (HP:0009775)3.04465466
41Abnormality of placental membranes (HP:0011409)3.04465466
42Myoglobinuria (HP:0002913)3.03087914
43Increased variability in muscle fiber diameter (HP:0003557)3.01510680
44Right ventricular cardiomyopathy (HP:0011663)2.99131194
45Hepatoblastoma (HP:0002884)2.96794931
46Abnormality of skeletal muscle fiber size (HP:0012084)2.96515769
47Testicular atrophy (HP:0000029)2.95009731
48Hyperinsulinemic hypoglycemia (HP:0000825)2.94616450
49Absent phalangeal crease (HP:0006109)2.90259374
50Visceral angiomatosis (HP:0100761)2.89621651
51Hip contracture (HP:0003273)2.87813304
52Prolonged QT interval (HP:0001657)2.84165030
53Pancreatic islet-cell hyperplasia (HP:0004510)2.82300063
54Syncope (HP:0001279)2.81107049
55Asymmetric septal hypertrophy (HP:0001670)2.79288495
56Ventricular arrhythmia (HP:0004308)2.79058216
57Progressive muscle weakness (HP:0003323)2.78666261
58Aplasia of the musculature (HP:0100854)2.75030034
59Hemangiomatosis (HP:0007461)2.74998766
60Arterial tortuosity (HP:0005116)2.73134037
61Lymphangioma (HP:0100764)2.71243651
62Nonimmune hydrops fetalis (HP:0001790)2.70611113
63Deformed tarsal bones (HP:0008119)2.69667366
64Vascular tortuosity (HP:0004948)2.69290956
65Fatigable weakness (HP:0003473)2.68751963
66Abnormality of the neuromuscular junction (HP:0003398)2.68751963
67Mildly elevated creatine phosphokinase (HP:0008180)2.65208955
68Trismus (HP:0000211)2.64295650
69Hematochezia (HP:0002573)2.63140099
70Fetal akinesia sequence (HP:0001989)2.62566734
71Aortic aneurysm (HP:0004942)2.62490677
72Weak cry (HP:0001612)2.60847580
73Partial duplication of thumb phalanx (HP:0009944)2.59319881
74Muscle stiffness (HP:0003552)2.54204714
75Increased serum pyruvate (HP:0003542)2.45395375
76Abnormality of glycolysis (HP:0004366)2.45395375
77Palpitations (HP:0001962)2.43594552
78Aortic dissection (HP:0002647)2.43391336
79Limb-girdle muscle atrophy (HP:0003797)2.42090027
80Bulbar palsy (HP:0001283)2.42053480
81Limited hip movement (HP:0008800)2.41480724
82Cerebral hemorrhage (HP:0001342)2.38930918
83Wrist flexion contracture (HP:0001239)2.38814824
84Bundle branch block (HP:0011710)2.37591998
85Difficulty climbing stairs (HP:0003551)2.35694747
86Broad metatarsal (HP:0001783)2.35667914
87Abnormal EKG (HP:0003115)2.35527998
88Distal lower limb amyotrophy (HP:0008944)2.33219087
89Tetraparesis (HP:0002273)2.32560366
90Neck muscle weakness (HP:0000467)2.31421143
91Abnormal finger flexion creases (HP:0006143)2.30987228
92Myopathic facies (HP:0002058)2.30397461
93Type 2 muscle fiber atrophy (HP:0003554)2.28634586
94Atrioventricular block (HP:0001678)2.28611407
95Preauricular pit (HP:0004467)2.28229968
96Periauricular skin pits (HP:0100277)2.28229968
97Pterygium (HP:0001059)2.27173507
98Scapular winging (HP:0003691)2.27042077
99Heart block (HP:0012722)2.24921608
100Reduced subcutaneous adipose tissue (HP:0003758)2.23588112
101Generalized muscle weakness (HP:0003324)2.23054359
102Ependymoma (HP:0002888)2.22267125
103Rhabdomyolysis (HP:0003201)2.22133451
104Thin ribs (HP:0000883)2.21160269
105Hypoplasia of the iris (HP:0007676)2.20494647
106EMG: neuropathic changes (HP:0003445)2.20285470
107Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.20035261
108Muscle fiber inclusion bodies (HP:0100299)2.19231993
109Rimmed vacuoles (HP:0003805)2.17693681
110Abnormality of the pulmonary veins (HP:0011718)2.16692048
111Abnormal atrioventricular conduction (HP:0005150)2.15822520
112Abnormality of the calcaneus (HP:0008364)2.14339899
113Distal lower limb muscle weakness (HP:0009053)2.13381589
114Partial duplication of the phalanx of hand (HP:0009999)2.12831945
115Myocardial infarction (HP:0001658)2.11405424
116Skull defect (HP:0001362)2.06039623
117Muscle fiber atrophy (HP:0100295)2.04590288
118Ventricular fibrillation (HP:0001663)2.04503596
119Pulmonary artery stenosis (HP:0004415)2.03943453
120Microcytic anemia (HP:0001935)2.00940996
121Abnormality of the pubic bones (HP:0003172)1.95970588
122Capillary hemangiomas (HP:0005306)1.95319372
123Abnormality of the lower motor neuron (HP:0002366)1.94433687
124Type 1 muscle fiber predominance (HP:0003803)1.94405300
125Generalized amyotrophy (HP:0003700)1.94013199
126Esophageal varix (HP:0002040)1.92023829
127Nemaline bodies (HP:0003798)1.91328342
128Rib fusion (HP:0000902)1.86775379
129Areflexia of lower limbs (HP:0002522)1.86727687
130Atrophic scars (HP:0001075)1.86652956
131Nephroblastoma (Wilms tumor) (HP:0002667)1.85498273
132Centrally nucleated skeletal muscle fibers (HP:0003687)1.84994006
133Easy fatigability (HP:0003388)1.84593163
134Muscular dystrophy (HP:0003560)1.83909529
135Skin pits (HP:0100276)1.82979628
136Abnormal cartilage morphology (HP:0002763)1.80954812
137Hypoplastic left heart (HP:0004383)1.80809375
138Rectovaginal fistula (HP:0000143)1.76946632
139Rectal fistula (HP:0100590)1.76946632
140Fused cervical vertebrae (HP:0002949)1.76085207
141Dicarboxylic aciduria (HP:0003215)1.73639054
142Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73639054
143Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72298878
144Embryonal renal neoplasm (HP:0011794)1.67831045
145Rapidly progressive (HP:0003678)1.67704788
146Muscle fibrillation (HP:0010546)1.67478079
147Gowers sign (HP:0003391)1.66206809
148Neoplasm of striated muscle (HP:0009728)1.63797978
149Abnormal lung lobation (HP:0002101)1.63505489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.88215566
2TGFBR24.57488794
3CDK123.80045520
4KDR3.29921383
5ERN12.73896056
6GRK12.72564389
7GRK52.68509845
8OBSCN2.46415535
9MYLK2.39379577
10TTN2.28330445
11FER2.06608270
12GRK72.03416266
13TGFBR11.95862245
14CSF1R1.95243244
15PRKG21.93442970
16MAPK71.89262666
17MATK1.87223465
18RIPK11.79254381
19PIK3CG1.71540538
20LATS21.64512619
21WNK11.59181604
22ADRBK21.55792476
23BCKDK1.54556042
24PAK41.53874972
25PDK21.52525171
26DMPK1.51674331
27MAP2K31.50503056
28PHKG11.50050742
29PHKG21.50050742
30STK101.47497503
31PKN21.47363801
32MAPK121.41301064
33LMTK21.40922556
34FES1.40743647
35MUSK1.33419761
36GRK61.33234419
37EPHB11.30053312
38CAMK41.28597393
39STK391.24883003
40LIMK11.23334941
41TESK11.16061103
42ARAF1.15282123
43TRIB31.14041512
44MARK21.12454670
45PDK41.11935537
46PDK31.11935537
47TYRO31.09706235
48MAP3K71.06828035
49NEK91.05673318
50STK241.04666186
51PRKD10.98194111
52MAP3K130.91637926
53MOS0.91335344
54FLT30.88592312
55PTK2B0.88343219
56DDR20.87337214
57ILK0.84601566
58KIT0.84010135
59ERBB40.83073501
60EEF2K0.82145009
61ROCK10.79465582
62MAP2K60.78638350
63WNK40.76317498
64PIK3CA0.75871418
65LRRK20.75818480
66TTK0.75408734
67LATS10.72240213
68CDK80.68038461
69MAP3K120.64082960
70AKT20.63735014
71EPHA20.63192126
72PRKAA20.61176589
73HIPK20.58730485
74ABL20.58103089
75MAPKAPK50.57534305
76OXSR10.56462926
77CCNB10.56446530
78ADRBK10.55746243
79CSK0.54711215
80PDGFRB0.53546523
81MAPKAPK30.53402466
82ITK0.53245757
83CAMK10.52702101
84BMPR1B0.51740913
85FGFR30.49799902
86TRPM70.49451823
87RPS6KA20.47494290
88PRKACB0.47228702
89NTRK10.46220154
90MAP3K30.44780126
91CDK70.43566985
92MAP4K20.43329441
93IRAK30.43021851
94INSRR0.42706055
95PDGFRA0.40647512
96MAP2K10.40378717
97IGF1R0.40222160
98PTK60.40119585
99PINK10.39030245
100MET0.39012976
101MAP3K90.38897365
102MST1R0.38522164
103PRKD20.36718223
104CDC42BPA0.36347040
105KSR20.36156704
106STK40.35887444
107MAP2K40.35299947
108MAPK40.34202288
109TEC0.32309244
110EPHB20.30371604
111PRKAA10.28976953
112PKN10.28456277
113PRKD30.27992034
114RPS6KB20.27857368
115CDK90.27524959
116GSK3A0.27100567
117PTK20.26094051
118DAPK30.25978342
119PAK30.25566506
120PDK10.25125526
121ROCK20.24449259
122NEK10.24329784
123PAK20.23612388
124EGFR0.23268598
125ICK0.22907959
126FGFR20.22838971
127FGFR40.20968326
128CAMK2G0.20885604
129CDK60.19997004
130PDPK10.19673950
131MAP3K10.19619078
132MTOR0.19223363
133INSR0.18865198
134CAMK2D0.18655814
135ZAP700.18253105
136MAP3K60.18147251
137MAPKAPK20.18036873
138PRKACA0.17961265
139PRKG10.17849403
140SRC0.16760705
141MAP3K80.14660760
142STK38L0.14417944
143MAP3K50.12555198

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.20704983
2Dilated cardiomyopathy_Homo sapiens_hsa054143.69539808
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.63313481
4Cardiac muscle contraction_Homo sapiens_hsa042603.28057290
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.91766439
6Vitamin B6 metabolism_Homo sapiens_hsa007502.82729175
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.51107200
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.50938745
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20354173
10Propanoate metabolism_Homo sapiens_hsa006402.14969561
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.96203224
12Leukocyte transendothelial migration_Homo sapiens_hsa046701.88199129
13Fatty acid elongation_Homo sapiens_hsa000621.87859588
14Arachidonic acid metabolism_Homo sapiens_hsa005901.75632995
15Fructose and mannose metabolism_Homo sapiens_hsa000511.73315561
16Parkinsons disease_Homo sapiens_hsa050121.71986261
17Fatty acid degradation_Homo sapiens_hsa000711.70025264
18ECM-receptor interaction_Homo sapiens_hsa045121.68039347
19Focal adhesion_Homo sapiens_hsa045101.67105239
20Carbon metabolism_Homo sapiens_hsa012001.65434321
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60776033
22Tight junction_Homo sapiens_hsa045301.57528851
23Galactose metabolism_Homo sapiens_hsa000521.44445910
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41444301
25Ovarian steroidogenesis_Homo sapiens_hsa049131.37841242
26Platelet activation_Homo sapiens_hsa046111.35481365
27Viral myocarditis_Homo sapiens_hsa054161.34726055
28Prion diseases_Homo sapiens_hsa050201.31905863
29Adherens junction_Homo sapiens_hsa045201.28568038
30Rap1 signaling pathway_Homo sapiens_hsa040151.27352269
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22584102
32Circadian rhythm_Homo sapiens_hsa047101.20844106
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20735815
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.19138111
35Fatty acid metabolism_Homo sapiens_hsa012121.18584253
36Oxidative phosphorylation_Homo sapiens_hsa001901.16620626
37Dorso-ventral axis formation_Homo sapiens_hsa043201.09265806
38Notch signaling pathway_Homo sapiens_hsa043301.07821991
39Alzheimers disease_Homo sapiens_hsa050101.06588715
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06475008
41HIF-1 signaling pathway_Homo sapiens_hsa040661.05590754
42Arginine biosynthesis_Homo sapiens_hsa002201.03705131
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03414609
44Insulin signaling pathway_Homo sapiens_hsa049101.03399130
45Thyroid cancer_Homo sapiens_hsa052160.97623789
46Pathways in cancer_Homo sapiens_hsa052000.96772691
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96238083
48PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93652604
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93371708
50Linoleic acid metabolism_Homo sapiens_hsa005910.90971627
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.90885602
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89057918
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87326055
54VEGF signaling pathway_Homo sapiens_hsa043700.86945300
55Pentose phosphate pathway_Homo sapiens_hsa000300.86833083
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83263370
57Huntingtons disease_Homo sapiens_hsa050160.83027381
58Complement and coagulation cascades_Homo sapiens_hsa046100.82370122
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82022354
60Insulin resistance_Homo sapiens_hsa049310.79370267
61TGF-beta signaling pathway_Homo sapiens_hsa043500.77889018
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.77201884
63Pyruvate metabolism_Homo sapiens_hsa006200.76077842
64Bladder cancer_Homo sapiens_hsa052190.75695157
65Glucagon signaling pathway_Homo sapiens_hsa049220.74709051
66Ribosome_Homo sapiens_hsa030100.73128779
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72547638
68Small cell lung cancer_Homo sapiens_hsa052220.69787824
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68869354
70Proteoglycans in cancer_Homo sapiens_hsa052050.68295371
71Protein digestion and absorption_Homo sapiens_hsa049740.65782918
72Melanogenesis_Homo sapiens_hsa049160.62330639
73PPAR signaling pathway_Homo sapiens_hsa033200.62160102
74AMPK signaling pathway_Homo sapiens_hsa041520.61732885
75Arginine and proline metabolism_Homo sapiens_hsa003300.60987089
76Ether lipid metabolism_Homo sapiens_hsa005650.60141764
77Renin-angiotensin system_Homo sapiens_hsa046140.59935921
78Ras signaling pathway_Homo sapiens_hsa040140.59219623
79Tryptophan metabolism_Homo sapiens_hsa003800.58307874
80Calcium signaling pathway_Homo sapiens_hsa040200.57434698
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56633251
82Phenylalanine metabolism_Homo sapiens_hsa003600.56472613
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56282506
84Renal cell carcinoma_Homo sapiens_hsa052110.55865455
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54462885
86Gap junction_Homo sapiens_hsa045400.54424078
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54100027
88GnRH signaling pathway_Homo sapiens_hsa049120.53646022
89Renin secretion_Homo sapiens_hsa049240.53365557
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.53302192
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52034070
92Pancreatic cancer_Homo sapiens_hsa052120.51592336
93Other glycan degradation_Homo sapiens_hsa005110.51170709
94Oxytocin signaling pathway_Homo sapiens_hsa049210.49389985
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49100563
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49067861
97Chronic myeloid leukemia_Homo sapiens_hsa052200.47259878
98Inositol phosphate metabolism_Homo sapiens_hsa005620.46771036
99cAMP signaling pathway_Homo sapiens_hsa040240.46758826
100Basal cell carcinoma_Homo sapiens_hsa052170.45562583
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44648633
102Biosynthesis of amino acids_Homo sapiens_hsa012300.44589782
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44223888
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.43763633
105Vitamin digestion and absorption_Homo sapiens_hsa049770.43245370
106Bile secretion_Homo sapiens_hsa049760.41787260
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41668783
108Toxoplasmosis_Homo sapiens_hsa051450.41355625
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41342122
110Glioma_Homo sapiens_hsa052140.40161254
111Sulfur metabolism_Homo sapiens_hsa009200.39616267
112Acute myeloid leukemia_Homo sapiens_hsa052210.37158406
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36106093
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36001620
115Starch and sucrose metabolism_Homo sapiens_hsa005000.34679876
116Hippo signaling pathway_Homo sapiens_hsa043900.34379468
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33912476
118Melanoma_Homo sapiens_hsa052180.33465218
119Estrogen signaling pathway_Homo sapiens_hsa049150.33359525
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33168656
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.33080474
122MAPK signaling pathway_Homo sapiens_hsa040100.32631846
123Lysosome_Homo sapiens_hsa041420.32012142
124Endocytosis_Homo sapiens_hsa041440.31797403
125FoxO signaling pathway_Homo sapiens_hsa040680.30487126
126Gastric acid secretion_Homo sapiens_hsa049710.29820784
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28902607
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28653454
129Amoebiasis_Homo sapiens_hsa051460.28298582
130Axon guidance_Homo sapiens_hsa043600.28158707
131Hematopoietic cell lineage_Homo sapiens_hsa046400.28005410
132MicroRNAs in cancer_Homo sapiens_hsa052060.27880370
133African trypanosomiasis_Homo sapiens_hsa051430.26990140
134Malaria_Homo sapiens_hsa051440.26216116
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25992362

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