AFAP1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.69518359
2vascular endothelial growth factor signaling pathway (GO:0038084)4.52693689
3lymph vessel development (GO:0001945)4.08210502
4regulation of water loss via skin (GO:0033561)3.96655123
5establishment of skin barrier (GO:0061436)3.79627942
6myelination in peripheral nervous system (GO:0022011)3.73862894
7peripheral nervous system axon ensheathment (GO:0032292)3.73862894
8keratinocyte proliferation (GO:0043616)3.70712585
9lymphangiogenesis (GO:0001946)3.59334021
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.53447220
11endothelium development (GO:0003158)3.49706307
12skin morphogenesis (GO:0043589)3.38198774
13membrane raft organization (GO:0031579)3.27276358
14negative regulation of stress fiber assembly (GO:0051497)3.27185228
15locomotory exploration behavior (GO:0035641)3.26858011
16cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.24207600
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.22979066
18cerebellar granule cell differentiation (GO:0021707)3.17577191
19negative regulation of hormone biosynthetic process (GO:0032353)3.10456302
20negative regulation of hormone metabolic process (GO:0032351)3.10456302
21cell-cell junction maintenance (GO:0045217)3.06458184
22cytidine deamination (GO:0009972)3.06137028
23cytidine metabolic process (GO:0046087)3.06137028
24cytidine catabolic process (GO:0006216)3.06137028
25thyroid gland development (GO:0030878)3.05169389
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03530658
27renal filtration (GO:0097205)3.02591248
28basement membrane organization (GO:0071711)3.00242764
29cell junction maintenance (GO:0034331)2.95263065
30potassium ion import (GO:0010107)2.93251813
31negative regulation of actin filament bundle assembly (GO:0032232)2.88757095
32positive regulation of osteoblast proliferation (GO:0033690)2.88604796
33negative regulation of homotypic cell-cell adhesion (GO:0034111)2.88350847
34cell adhesion mediated by integrin (GO:0033627)2.87907583
35regulation of transforming growth factor beta2 production (GO:0032909)2.86646450
36negative regulation of chondrocyte differentiation (GO:0032331)2.86146224
37cell communication by electrical coupling (GO:0010644)2.85299933
38neuronal action potential propagation (GO:0019227)2.82514410
39multicellular organismal water homeostasis (GO:0050891)2.82272457
40cell communication involved in cardiac conduction (GO:0086065)2.81318474
41negative regulation of catenin import into nucleus (GO:0035414)2.80919133
42negative regulation of platelet activation (GO:0010544)2.80769181
43thyroid hormone metabolic process (GO:0042403)2.79260509
44regulation of female gonad development (GO:2000194)2.76915897
45protein localization to cell surface (GO:0034394)2.75176714
46glutamate secretion (GO:0014047)2.74820129
47regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.73413977
48pyrimidine ribonucleoside catabolic process (GO:0046133)2.71028781
49regulation of hippo signaling (GO:0035330)2.70392643
50cell-substrate junction assembly (GO:0007044)2.69347284
51glomerular filtration (GO:0003094)2.67636957
52peptidyl-tyrosine autophosphorylation (GO:0038083)2.67478205
53regulation of axon extension involved in axon guidance (GO:0048841)2.67079526
54establishment of protein localization to plasma membrane (GO:0090002)2.61108294
55collecting duct development (GO:0072044)2.60796973
56branching involved in salivary gland morphogenesis (GO:0060445)2.60675751
57surfactant homeostasis (GO:0043129)2.60519230
58layer formation in cerebral cortex (GO:0021819)2.59748525
59notochord development (GO:0030903)2.56244668
60nephron tubule formation (GO:0072079)2.55682426
61positive regulation of odontogenesis (GO:0042482)2.55443574
62regulation of endothelial cell differentiation (GO:0045601)2.55279942
63establishment of nucleus localization (GO:0040023)2.52323329
64cell-substrate adherens junction assembly (GO:0007045)2.50958468
65focal adhesion assembly (GO:0048041)2.50958468
66keratinization (GO:0031424)2.50414680
67gap junction assembly (GO:0016264)2.50017575
68renal system development (GO:0072001)2.48496461
69protein heterotrimerization (GO:0070208)2.48130402
70glomerular basement membrane development (GO:0032836)2.48100955
71positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47433283
72mesodermal cell differentiation (GO:0048333)2.45721168
73response to pheromone (GO:0019236)2.45384800
74substrate adhesion-dependent cell spreading (GO:0034446)2.44329702
75lateral sprouting from an epithelium (GO:0060601)2.44196517
76sodium ion export (GO:0071436)2.44115515
77neuronal ion channel clustering (GO:0045161)2.42976461
78positive regulation of endothelial cell differentiation (GO:0045603)2.42948229
79protein targeting to plasma membrane (GO:0072661)2.42663294
80retina vasculature morphogenesis in camera-type eye (GO:0061299)2.41345994
81platelet-derived growth factor receptor signaling pathway (GO:0048008)2.40360026
82positive regulation of endothelial cell apoptotic process (GO:2000353)2.40177791
83negative regulation of cartilage development (GO:0061037)2.40100753
84eosinophil chemotaxis (GO:0048245)2.39421840
85endothelial cell chemotaxis (GO:0035767)2.38221920
86regulation of axon guidance (GO:1902667)2.38175945
87metanephric nephron epithelium development (GO:0072243)2.37962981
88peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.37664916
89anatomical structure arrangement (GO:0048532)2.35526121
90semaphorin-plexin signaling pathway (GO:0071526)2.35330565
91regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.35145417
92angiogenesis involved in wound healing (GO:0060055)2.34910245
93myelin maintenance (GO:0043217)2.34884709
94cellular sodium ion homeostasis (GO:0006883)2.34789856
95regulation of glucose import in response to insulin stimulus (GO:2001273)2.34718590
96positive regulation of astrocyte differentiation (GO:0048711)2.34634599
97negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.33803855
98muscle cell migration (GO:0014812)2.33585872
99atrioventricular valve morphogenesis (GO:0003181)2.31554195
100cell volume homeostasis (GO:0006884)2.30896659
101thyroid hormone generation (GO:0006590)2.30628159
102COPI coating of Golgi vesicle (GO:0048205)2.30408682
103Golgi transport vesicle coating (GO:0048200)2.30408682
104regulation of keratinocyte proliferation (GO:0010837)2.29401732
105water homeostasis (GO:0030104)2.29396014
106hippo signaling (GO:0035329)2.29319499
107positive regulation of neurological system process (GO:0031646)2.28912906
108adherens junction assembly (GO:0034333)2.28812782
109somatic stem cell division (GO:0048103)2.28644567
110glial cell migration (GO:0008347)2.28147461
111regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.27792223
112regulation of p38MAPK cascade (GO:1900744)2.27555391
113negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.27215406
114intermediate filament organization (GO:0045109)2.26889994
115negative regulation of smooth muscle cell differentiation (GO:0051151)2.26750557
116dermatan sulfate biosynthetic process (GO:0030208)2.26539686
117mesonephros development (GO:0001823)2.26319519
118regulation of hair follicle development (GO:0051797)2.25578025
119inositol phosphate-mediated signaling (GO:0048016)2.25558883
120peptide cross-linking (GO:0018149)2.25386499
121positive regulation of adherens junction organization (GO:1903393)2.24944221
122neuron projection extension involved in neuron projection guidance (GO:1902284)2.24879002
123axon extension involved in axon guidance (GO:0048846)2.24879002
124cell junction assembly (GO:0034329)2.24825955
125aorta morphogenesis (GO:0035909)2.24784621
126mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.23443516
127extracellular fibril organization (GO:0043206)2.22879411
128response to water (GO:0009415)2.22731402
129protein localization to endosome (GO:0036010)2.22690347
130regulation of protein localization to cell surface (GO:2000008)2.22033191
131potassium ion homeostasis (GO:0055075)2.21180605
132vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.20900934
133cell migration in hindbrain (GO:0021535)2.20735989
134positive regulation of p38MAPK cascade (GO:1900745)2.20437104
135plasma membrane repair (GO:0001778)2.19982431
136positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.19100346
137cell junction organization (GO:0034330)2.18972925
138regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.18487665
139negative regulation of keratinocyte proliferation (GO:0010839)2.18431349
140endocardial cushion development (GO:0003197)2.18049530
141adherens junction organization (GO:0034332)2.17937020
142establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.17834156
143epithelial cell-cell adhesion (GO:0090136)2.17071757
144cell-cell junction assembly (GO:0007043)2.16772809
145face morphogenesis (GO:0060325)2.16570684
146regulation of glomerular filtration (GO:0003093)2.14788488
147cellular potassium ion homeostasis (GO:0030007)2.14266889
148wound healing, spreading of cells (GO:0044319)2.13679606
149cell-matrix adhesion (GO:0007160)2.13038091
150blood vessel maturation (GO:0001955)2.12716326
151glomerulus development (GO:0032835)2.12685487
152desmosome organization (GO:0002934)2.12073506
153positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.09847102
154nucleus localization (GO:0051647)2.09651666
155bundle of His cell to Purkinje myocyte communication (GO:0086069)2.09597280
156regulation of cardioblast differentiation (GO:0051890)2.08784605
157cell-cell junction organization (GO:0045216)2.08029029
158dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.07895530
159positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.07095237
160collagen fibril organization (GO:0030199)2.07045480
161ovulation cycle (GO:0042698)2.06992023
162regulation of vasculogenesis (GO:2001212)2.05731522
163cranial nerve structural organization (GO:0021604)2.05633585
164establishment or maintenance of bipolar cell polarity (GO:0061245)2.04888432
165establishment or maintenance of apical/basal cell polarity (GO:0035088)2.04888432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.21429072
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.68846360
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.61316960
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.52898938
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40336855
6AR_21572438_ChIP-Seq_LNCaP_Human2.38989408
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37386831
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24380642
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16275203
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16275203
11EED_16625203_ChIP-ChIP_MESCs_Mouse1.92221108
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91571548
13JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91514081
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89052895
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87661066
16* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.87637737
17* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.87637737
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84251276
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83188953
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83149068
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.81837999
22* ESR2_21235772_ChIP-Seq_MCF-7_Human1.80682869
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77536021
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.77163504
25* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.74233942
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.71245666
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70535214
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.69848940
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67865157
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.64902456
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61339763
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.60850256
33EZH2_22144423_ChIP-Seq_EOC_Human1.59442442
34* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58820874
35P63_26484246_Chip-Seq_KERATINOCYTES_Human1.55435806
36GBX2_23144817_ChIP-Seq_PC3_Human1.52809742
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.48905633
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48481087
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48355061
40* ESR1_21235772_ChIP-Seq_MCF-7_Human1.48057160
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47126754
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46794574
43SOX2_20726797_ChIP-Seq_SW620_Human1.44429894
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43062845
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42493609
46AHR_22903824_ChIP-Seq_MCF-7_Human1.41534634
47* CJUN_26792858_Chip-Seq_BT549_Human1.39935350
48* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37403000
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37310213
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36929368
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36361938
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36080198
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.33593540
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.32545891
55DROSHA_22980978_ChIP-Seq_HELA_Human1.32451482
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32409391
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28442744
58TP53_16413492_ChIP-PET_HCT116_Human1.27892995
59KDM2B_26808549_Chip-Seq_K562_Human1.26857226
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26103590
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26023811
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.25051660
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.24513253
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24117999
65RACK7_27058665_Chip-Seq_MCF-7_Human1.23814944
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22573866
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.22030165
68LXR_22292898_ChIP-Seq_THP-1_Human1.21998158
69* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21574729
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.20540498
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.19357702
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.18034002
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17709909
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17526367
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17361216
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17090141
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16563352
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16058508
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.15194231
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13682850
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13224811
82* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13057210
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11947042
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09150070
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07963000
86SMAD3_21741376_ChIP-Seq_HESCs_Human1.07699124
87* SMAD4_21799915_ChIP-Seq_A2780_Human1.06926697
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06299280
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06226697
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.05443872
91* TP53_23651856_ChIP-Seq_MEFs_Mouse1.04425515
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04006573
93CDX2_20551321_ChIP-Seq_CACO-2_Human1.03037112
94AR_19668381_ChIP-Seq_PC3_Human1.01513262
95* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01269845
96TP63_22573176_ChIP-Seq_HFKS_Human1.01032771
97BCAT_22108803_ChIP-Seq_LS180_Human1.00746687
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00088801
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00088801
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00088801
101TP53_18474530_ChIP-ChIP_U2OS_Human0.99834424
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99671868
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.99641485
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99447010
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97563417
106DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97234361
107CLOCK_20551151_ChIP-Seq_293T_Human0.96350953
108* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96259396
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96099799
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.95757740
111RARB_27405468_Chip-Seq_BRAIN_Mouse0.95553384
112UBF1/2_26484160_Chip-Seq_HMECs_Human0.95536269
113TP63_23658742_ChIP-Seq_EP156T_Human0.95344704
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95293377
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95246498
116STAT3_23295773_ChIP-Seq_U87_Human0.95107733
117IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94525822
118SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94455600
119* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94155291
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93905931
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93737137
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93479070
123* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93010562
124ZNF263_19887448_ChIP-Seq_K562_Human0.92765623
125* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92580440
126STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92394112
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92335832
128ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92087662
129RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91879075
130KLF5_25053715_ChIP-Seq_YYC3_Human0.91757021
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90762530
132* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90164952
133TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89905264
134ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89516372
135TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89463093
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89419470
137TBX20_22080862_ChIP-Seq_HEART_Mouse0.89120962
138TBX20_22328084_ChIP-Seq_HEART_Mouse0.89120962
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89081790
140RUNX1_27514584_Chip-Seq_MCF-7_Human0.87209762
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84602326
142EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83327838
143NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83074206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane5.23301815
2MP0005623_abnormal_meninges_morphology3.75898766
3MP0006054_spinal_hemorrhage2.50632673
4MP0000013_abnormal_adipose_tissue2.41551523
5MP0008438_abnormal_cutaneous_collagen2.38659941
6MP0010368_abnormal_lymphatic_system2.33521978
7MP0005257_abnormal_intraocular_pressure2.31596662
8MP0009384_cardiac_valve_regurgitation2.30446911
9MP0004858_abnormal_nervous_system2.26885849
10MP0000681_abnormal_thyroid_gland2.17164136
11MP0000566_synostosis2.14637155
12MP0003045_fibrosis2.12952811
13MP0003941_abnormal_skin_development2.11267763
14MP0002877_abnormal_melanocyte_morpholog2.07512467
15MP0003705_abnormal_hypodermis_morpholog2.06107590
16MP0005275_abnormal_skin_tensile2.00229186
17MP0000678_abnormal_parathyroid_gland1.99402029
18MP0005409_darkened_coat_color1.98882008
19MP0000383_abnormal_hair_follicle1.97696084
20MP0003878_abnormal_ear_physiology1.97091729
21MP0005377_hearing/vestibular/ear_phenot1.97091729
22MP0005023_abnormal_wound_healing1.91532477
23MP0010678_abnormal_skin_adnexa1.88726047
24MP0000579_abnormal_nail_morphology1.82311226
25MP0003385_abnormal_body_wall1.77205349
26MP0001879_abnormal_lymphatic_vessel1.76408359
27MP0005501_abnormal_skin_physiology1.74808748
28MP0010234_abnormal_vibrissa_follicle1.70822001
29MP0000462_abnormal_digestive_system1.69133797
30MP0002254_reproductive_system_inflammat1.67360187
31MP0004270_analgesia1.66712249
32MP0001958_emphysema1.66203854
33MP0001216_abnormal_epidermal_layer1.64112271
34MP0004264_abnormal_extraembryonic_tissu1.62411071
35MP0005503_abnormal_tendon_morphology1.58587061
36MP0003879_abnormal_hair_cell1.54061229
37MP0004145_abnormal_muscle_electrophysio1.52746216
38MP0003329_amyloid_beta_deposits1.49998169
39MP0004859_abnormal_synaptic_plasticity1.49242472
40MP0003091_abnormal_cell_migration1.46316956
41MP0009250_abnormal_appendicular_skeleto1.45563870
42MP0000534_abnormal_ureter_morphology1.45507913
43MP0003566_abnormal_cell_adhesion1.42637946
44MP0001915_intracranial_hemorrhage1.39014725
45MP0003279_aneurysm1.38831899
46MP0005167_abnormal_blood-brain_barrier1.36965070
47MP0001849_ear_inflammation1.36577547
48MP0005165_increased_susceptibility_to1.36398372
49MP0004947_skin_inflammation1.36211132
50MP0002909_abnormal_adrenal_gland1.35154958
51MP0003136_yellow_coat_color1.32175408
52MP0000467_abnormal_esophagus_morphology1.32008559
53MP0000767_abnormal_smooth_muscle1.31457005
54MP0005464_abnormal_platelet_physiology1.29898518
55MP0003632_abnormal_nervous_system1.28597513
56MP0004885_abnormal_endolymph1.26141289
57MP0005187_abnormal_penis_morphology1.26120753
58MP0000751_myopathy1.26047504
59MP0000733_abnormal_muscle_development1.25043844
60MP0005508_abnormal_skeleton_morphology1.24870495
61MP0001661_extended_life_span1.23979659
62MP0000377_abnormal_hair_follicle1.23301936
63MP0002295_abnormal_pulmonary_circulatio1.18499849
64MP0005171_absent_coat_pigmentation1.18084465
65MP0002876_abnormal_thyroid_physiology1.18004822
66MP0003755_abnormal_palate_morphology1.17765442
67MP0000920_abnormal_myelination1.16779129
68MP0001501_abnormal_sleep_pattern1.16596824
69MP0001346_abnormal_lacrimal_gland1.15307040
70MP0002060_abnormal_skin_morphology1.13194858
71MP0001851_eye_inflammation1.13189048
72MP0002796_impaired_skin_barrier1.10396017
73MP0000762_abnormal_tongue_morphology1.09548962
74MP0002249_abnormal_larynx_morphology1.08901039
75MP0003942_abnormal_urinary_system1.07813465
76MP0002653_abnormal_ependyma_morphology1.07349882
77MP0000003_abnormal_adipose_tissue1.07296608
78MP0004185_abnormal_adipocyte_glucose1.06433908
79MP0003075_altered_response_to1.06328118
80MP0002098_abnormal_vibrissa_morphology1.05295507
81MP0006138_congestive_heart_failure1.05133656
82MP0003935_abnormal_craniofacial_develop1.04967793
83MP0002896_abnormal_bone_mineralization1.04447035
84MP0008569_lethality_at_weaning1.04076375
85MP0001348_abnormal_lacrimal_gland1.03684493
86MP0001299_abnormal_eye_distance/1.03589445
87MP0000647_abnormal_sebaceous_gland1.02709731
88MP0005248_abnormal_Harderian_gland1.01079473
89MP0003937_abnormal_limbs/digits/tail_de1.00714708
90MP0003453_abnormal_keratinocyte_physiol1.00229569
91MP0001968_abnormal_touch/_nociception0.99205478
92MP0004084_abnormal_cardiac_muscle0.99083176
93MP0002932_abnormal_joint_morphology0.97696846
94MP0000537_abnormal_urethra_morphology0.96769279
95MP0004043_abnormal_pH_regulation0.96508654
96MP0000432_abnormal_head_morphology0.96263412
97MP0002116_abnormal_craniofacial_bone0.95574835
98MP0004742_abnormal_vestibular_system0.93492046
99MP0002734_abnormal_mechanical_nocicepti0.93413982
100MP0004215_abnormal_myocardial_fiber0.92638314
101MP0004484_altered_response_of0.92031783
102MP0005423_abnormal_somatic_nervous0.91203130
103MP0010771_integument_phenotype0.89185562
104MP0002282_abnormal_trachea_morphology0.89085821
105MP0002108_abnormal_muscle_morphology0.87837926
106MP0002168_other_aberrant_phenotype0.87598709
107MP0002925_abnormal_cardiovascular_devel0.87552368
108MP0001502_abnormal_circadian_rhythm0.87080437
109MP0009046_muscle_twitch0.86815736
110MP0004381_abnormal_hair_follicle0.86777585
111MP0003634_abnormal_glial_cell0.86680279
112MP0002233_abnormal_nose_morphology0.86111708
113MP0005595_abnormal_vascular_smooth0.85401745
114MP0000516_abnormal_urinary_system0.84525893
115MP0005367_renal/urinary_system_phenotyp0.84525893
116MP0009780_abnormal_chondrocyte_physiolo0.84027267
117MP0010030_abnormal_orbit_morphology0.83969066
118MP0002184_abnormal_innervation0.83962488
119MP0003300_gastrointestinal_ulcer0.82953760
120MP0001765_abnormal_ion_homeostasis0.82720966
121MP0000627_abnormal_mammary_gland0.81933174
122MP0003635_abnormal_synaptic_transmissio0.81607513
123MP0008775_abnormal_heart_ventricle0.81467705
124MP0008004_abnormal_stomach_pH0.80526089
125MP0009053_abnormal_anal_canal0.80262401
126MP0004883_abnormal_blood_vessel0.80021605
127MP0002234_abnormal_pharynx_morphology0.79809236
128MP0002089_abnormal_postnatal_growth/wei0.79804485
129MP0000427_abnormal_hair_cycle0.78879729
130MP0000163_abnormal_cartilage_morphology0.78053041
131MP0000428_abnormal_craniofacial_morphol0.77948328
132MP0003448_altered_tumor_morphology0.77174575
133MP0000778_abnormal_nervous_system0.76553717
134MP0002177_abnormal_outer_ear0.75306076
135MP0005164_abnormal_response_to0.74412750
136MP0005408_hypopigmentation0.74182243
137MP0001905_abnormal_dopamine_level0.71121339
138MP0004036_abnormal_muscle_relaxation0.70946996
139MP0001191_abnormal_skin_condition0.70166074
140MP0002972_abnormal_cardiac_muscle0.70040779
141MP0002063_abnormal_learning/memory/cond0.69124323
142MP0009931_abnormal_skin_appearance0.66160021
143MP0008260_abnormal_autophagy0.65642267
144MP0005193_abnormal_anterior_eye0.65582565
145MP0005166_decreased_susceptibility_to0.64501347
146MP0002736_abnormal_nociception_after0.59726808
147MP0005620_abnormal_muscle_contractility0.59656867
148MP0001340_abnormal_eyelid_morphology0.59238188

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)5.76045647
2Action tremor (HP:0002345)5.02115454
3Segmental peripheral demyelination/remyelination (HP:0003481)4.26179622
4Atrophic scars (HP:0001075)4.16923436
5Plantar hyperkeratosis (HP:0007556)4.11750192
6Termporal pattern (HP:0011008)3.97478379
7Insidious onset (HP:0003587)3.97478379
8Thick nail (HP:0001805)3.88098303
9Shallow orbits (HP:0000586)3.76187560
10Broad metatarsal (HP:0001783)3.75184810
11Ridged nail (HP:0001807)3.60973327
12Premature rupture of membranes (HP:0001788)3.58094740
13Abnormality of nail color (HP:0100643)3.54921165
14Palmoplantar hyperkeratosis (HP:0000972)3.16063229
15Milia (HP:0001056)3.14784621
16Pili torti (HP:0003777)3.11986574
17Nail dystrophy (HP:0008404)3.11576583
18Abnormality of oral frenula (HP:0000190)3.11074332
19Selective tooth agenesis (HP:0001592)3.04238511
20Thyroid-stimulating hormone excess (HP:0002925)3.04004460
21Ankle contracture (HP:0006466)3.03127701
22Palmar hyperkeratosis (HP:0010765)2.93761652
23Cerebral aneurysm (HP:0004944)2.91214467
24Neurofibrillary tangles (HP:0002185)2.88436512
25Onion bulb formation (HP:0003383)2.87659317
26Short hallux (HP:0010109)2.85084265
27Aortic dissection (HP:0002647)2.84257493
28Aplasia cutis congenita (HP:0001057)2.81892781
29Fragile skin (HP:0001030)2.80550210
30Increased CSF protein (HP:0002922)2.74798148
31Alacrima (HP:0000522)2.74274197
32Abnormal hair laboratory examination (HP:0003328)2.70924971
33Nasolacrimal duct obstruction (HP:0000579)2.68423848
34Goiter (HP:0000853)2.67332468
35Corneal erosion (HP:0200020)2.62205058
36Hypoplasia of dental enamel (HP:0006297)2.58785971
37Protrusio acetabuli (HP:0003179)2.56758315
38Aplasia/Hypoplasia of the hallux (HP:0008362)2.55660857
39Cerebral inclusion bodies (HP:0100314)2.54044045
40Steppage gait (HP:0003376)2.52912502
41Impaired proprioception (HP:0010831)2.50142927
42Vascular tortuosity (HP:0004948)2.49780666
43Postural tremor (HP:0002174)2.47553618
44Abnormality of the salivary glands (HP:0010286)2.45704412
45Bladder diverticulum (HP:0000015)2.42831158
46Abnormal blistering of the skin (HP:0008066)2.41211721
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.40111413
48Supranuclear gaze palsy (HP:0000605)2.39238901
49Ankyloglossia (HP:0010296)2.38795447
50Hypotrichosis (HP:0001006)2.34037066
51Right ventricular cardiomyopathy (HP:0011663)2.32485146
52Peripheral hypomyelination (HP:0007182)2.29655467
53Sparse eyelashes (HP:0000653)2.26005026
54Abnormality of binocular vision (HP:0011514)2.24984544
55Diplopia (HP:0000651)2.24984544
56Aortic aneurysm (HP:0004942)2.22440735
57Osteolytic defects of the hand bones (HP:0009699)2.20504930
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.20504930
59Broad face (HP:0000283)2.18644532
60Male infertility (HP:0003251)2.18527546
61Hyperparathyroidism (HP:0000843)2.18157623
62Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.17373869
63Abnormality of permanent molar morphology (HP:0011071)2.16844642
64Abnormality of the dental root (HP:0006486)2.16844642
65Taurodontia (HP:0000679)2.16844642
66Hammertoe (HP:0001765)2.16368168
67Hypoplasia of the iris (HP:0007676)2.16049307
68Arterial tortuosity (HP:0005116)2.15935466
69Distal lower limb muscle weakness (HP:0009053)2.14356809
70Abnormality of the lacrimal duct (HP:0011481)2.11754165
71Increased variability in muscle fiber diameter (HP:0003557)2.10105157
72Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.09534570
73Upper limb muscle weakness (HP:0003484)2.08966656
74Alopecia of scalp (HP:0002293)2.08227812
75Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.07790602
76Esophageal atresia (HP:0002032)2.07665153
77Abnormality of molar morphology (HP:0011070)2.04858587
78Abnormality of molar (HP:0011077)2.04858587
79Hoarse voice (HP:0001609)2.03628488
80Erythema (HP:0010783)2.03380572
81Trismus (HP:0000211)2.01930964
82Oligodactyly (hands) (HP:0001180)2.01047278
83Popliteal pterygium (HP:0009756)2.00977911
84Increased mean platelet volume (HP:0011877)2.00104100
85Aplasia involving bones of the upper limbs (HP:0009823)1.99835014
86Aplasia of the phalanges of the hand (HP:0009802)1.99835014
87Aplasia involving bones of the extremities (HP:0009825)1.99835014
88Sparse scalp hair (HP:0002209)1.99121581
89Decreased lacrimation (HP:0000633)1.97653284
90Hyperacusis (HP:0010780)1.96694250
91Abnormality of the dental pulp (HP:0006479)1.96608646
92Onycholysis (HP:0001806)1.96201612
93Mixed hearing impairment (HP:0000410)1.95478361
94Neoplasm of the heart (HP:0100544)1.95228409
95Hemiplegia (HP:0002301)1.94297316
96Menorrhagia (HP:0000132)1.93545621
97Natal tooth (HP:0000695)1.93014230
98Ventricular tachycardia (HP:0004756)1.91514668
99Fragile nails (HP:0001808)1.90994487
100Germ cell neoplasia (HP:0100728)1.89422181
101Spinal rigidity (HP:0003306)1.88002220
102Oligodontia (HP:0000677)1.87525157
103Follicular hyperkeratosis (HP:0007502)1.87143859
104Split foot (HP:0001839)1.86782432
105Vertebral arch anomaly (HP:0008438)1.86560812
106Abnormality of the vocal cords (HP:0008777)1.85569486
107Progressive cerebellar ataxia (HP:0002073)1.84702425
108Decreased motor nerve conduction velocity (HP:0003431)1.84172496
109Abnormality of the nasolacrimal system (HP:0000614)1.83620724
110Shawl scrotum (HP:0000049)1.82488281
111Venous abnormality (HP:0002624)1.81554806
112Absent toe (HP:0010760)1.81173655
113Advanced eruption of teeth (HP:0006288)1.81074823
114Foot dorsiflexor weakness (HP:0009027)1.79850708
115Hyperthyroidism (HP:0000836)1.79720904
116Corneal dystrophy (HP:0001131)1.78590497
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78483832
118Abnormality of the nasal septum (HP:0000419)1.78407982
119Mitral valve prolapse (HP:0001634)1.78093506
120Hyperextensible skin (HP:0000974)1.77831004
121Annular pancreas (HP:0001734)1.77829638
122Mesangial abnormality (HP:0001966)1.77352098
123Aneurysm (HP:0002617)1.76424393
124Erythroderma (HP:0001019)1.76211262
125Vascular calcification (HP:0004934)1.75286013
126Woolly hair (HP:0002224)1.73662637
127Conical tooth (HP:0000698)1.73496230
128Preaxial foot polydactyly (HP:0001841)1.73347709
129Venous insufficiency (HP:0005293)1.72415156
130Focal segmental glomerulosclerosis (HP:0000097)1.71971365
131Peripheral demyelination (HP:0011096)1.71891584
132Obstructive sleep apnea (HP:0002870)1.71707204
133Thyroid carcinoma (HP:0002890)1.70179972
134Lip pit (HP:0100267)1.69435399
135Soft skin (HP:0000977)1.69419544
136Distal upper limb amyotrophy (HP:0007149)1.69196969
137Upper limb amyotrophy (HP:0009129)1.69196969
138Xerostomia (HP:0000217)1.68413367
139Pterygium (HP:0001059)1.68090962
140Broad ribs (HP:0000885)1.67047676
141Hypoplastic ischia (HP:0003175)1.66431294
142Cervical subluxation (HP:0003308)1.66090795
143Increased connective tissue (HP:0009025)1.65927405
144Enlarged penis (HP:0000040)1.65505979
145Recurrent corneal erosions (HP:0000495)1.65227929
146Abnormality of skeletal muscle fiber size (HP:0012084)1.63558309
147Abnormal platelet volume (HP:0011876)1.63411370
148Muscle fiber splitting (HP:0003555)1.62257284
149Scapular winging (HP:0003691)1.61931448
150Hypoproteinemia (HP:0003075)1.61528851
151Overgrowth (HP:0001548)1.60844659
152Abnormality of the distal phalanges of the toes (HP:0010182)1.60805155
153Short nail (HP:0001799)1.60633702
154Difficulty climbing stairs (HP:0003551)1.59927543
155Adactyly (HP:0009776)1.59847442
156Hydroureter (HP:0000072)1.58411642
157Difficulty running (HP:0009046)1.57454014
158Abnormality of the foot musculature (HP:0001436)1.55753600
159Hand muscle atrophy (HP:0009130)1.55690867
160Limited hip movement (HP:0008800)1.55188669
161Abnormality of dentin (HP:0010299)1.54420204
162Bronchomalacia (HP:0002780)1.52489054
163Abnormality of the ischium (HP:0003174)1.52362105
164Hypoplastic nipples (HP:0002557)1.52146173
165Skull defect (HP:0001362)1.51881098
166Abnormality of the diencephalon (HP:0010662)1.49604118
167Chin dimple (HP:0010751)1.48626423
168Joint laxity (HP:0001388)1.47861274
169Split hand (HP:0001171)1.47089491
170Fibular aplasia (HP:0002990)1.46970128
171Down-sloping shoulders (HP:0200021)1.46512226
172Genetic anticipation (HP:0003743)1.46428300
173Genu recurvatum (HP:0002816)1.46399177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.29173973
2MST1R3.83621227
3TIE13.79655224
4LATS13.57732416
5KDR3.22708103
6EPHA42.88311915
7PDGFRA2.81595002
8LATS22.69484202
9MOS2.29757883
10CASK2.25330201
11EPHB22.22561326
12STK38L2.14715473
13FER2.12906493
14MAP3K122.06702446
15RIPK12.04949710
16ARAF1.95869740
17MYLK1.93347037
18EPHB11.92424491
19TYRO31.91432793
20DDR21.78359504
21TESK11.73380694
22MAP3K31.68820521
23DMPK1.68716101
24BMPR21.67642833
25PTK61.65452971
26PTK21.59468326
27TRIB31.53302972
28ILK1.49877880
29STK381.48845204
30MAP3K41.44468445
31MAP3K61.43592079
32NTRK21.33816657
33PIK3CA1.33101069
34PAK61.31351798
35TAOK11.30960335
36DAPK21.30898339
37MARK21.25634130
38SMG11.24888445
39MAP3K91.21793957
40ICK1.21108161
41NTRK11.19880794
42PDGFRB1.18945302
43MAPKAPK31.18645934
44MAP3K21.16779830
45EPHA31.14466339
46PRKD31.13401156
47TGFBR21.12404399
48KSR21.08122640
49MINK11.06275928
50CAMK2B1.03250320
51WNK11.03229471
52GRK51.01919379
53PAK41.00865673
54ERBB20.99118066
55EEF2K0.97631261
56RIPK40.94740683
57NEK60.93621538
58DAPK10.92709679
59STK100.92187732
60CAMK2G0.91260868
61MST40.90938021
62WNK40.89855164
63PAK30.89256539
64PTK2B0.88059646
65ROCK10.86827699
66TXK0.86364508
67STK240.86067749
68ERBB40.85954141
69PAK20.85205796
70CDC42BPA0.84912203
71TTN0.83518786
72LIMK10.83117154
73MAPK150.83034894
74MAPKAPK50.82442139
75ROCK20.82016975
76MUSK0.74981922
77TRPM70.74543952
78TTK0.74207326
79CAMK1G0.73637965
80PRKD20.73334956
81CSNK1A1L0.72603011
82STK30.70856839
83PHKG10.69640145
84PHKG20.69640145
85DAPK30.68723423
86PRKD10.66953839
87AKT30.66944257
88CDK90.66371137
89SIK10.66301619
90MAP2K10.64404002
91ERN10.61139635
92BMX0.60823338
93PLK40.59429655
94PDPK10.58338239
95MAPK70.58337067
96CAMK2D0.56848025
97FYN0.53746747
98MTOR0.51709387
99LRRK20.51142852
100CAMKK20.50755629
101SIK30.50412547
102PRKAA20.49318028
103MAP3K130.49197426
104SGK2230.47881582
105SGK4940.47881582
106MAPK120.47619151
107PLK20.47338366
108STK390.46840729
109PDK10.46316388
110GSK3A0.46287880
111SRC0.46174282
112KSR10.46039954
113CAMK40.45268230
114PRKCH0.45129548
115CAMKK10.44636662
116RPS6KA20.44488708
117LMTK20.44338333
118NTRK30.43364398
119ADRBK10.42457385
120MET0.42280550
121MAP3K10.42206781
122CSNK1G10.42192038
123TAOK30.41786935
124SCYL20.40926956
125MAP2K40.39481810
126CSNK1G20.39377247
127GRK10.39333535
128CAMK1D0.38518207
129MAPK130.38410388
130CSF1R0.38343781
131* RET0.38236408
132PRKG20.37990541
133ITK0.37934276
134CAMK2A0.37834854
135PAK10.37806939
136SGK10.37331417
137SGK20.35140597
138PRKCE0.35002360
139PRKAA10.34956881
140CDK50.34735136
141STK110.33490561
142IRAK30.32594620
143TGFBR10.32518668
144INSR0.29805953
145FGFR20.28769899
146IGF1R0.28356767
147JAK10.28068888
148MELK0.27671249
149PRKCI0.27002619

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.72984178
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15622841
3Focal adhesion_Homo sapiens_hsa045102.06849977
4Ovarian steroidogenesis_Homo sapiens_hsa049131.80672293
5Adherens junction_Homo sapiens_hsa045201.72203983
6Dorso-ventral axis formation_Homo sapiens_hsa043201.69926467
7Hippo signaling pathway_Homo sapiens_hsa043901.65159597
8Dilated cardiomyopathy_Homo sapiens_hsa054141.63815826
9Axon guidance_Homo sapiens_hsa043601.63308362
10Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.54708355
11Long-term depression_Homo sapiens_hsa047301.54226020
12Tight junction_Homo sapiens_hsa045301.45937488
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45052587
14Small cell lung cancer_Homo sapiens_hsa052221.42597894
15Autoimmune thyroid disease_Homo sapiens_hsa053201.42232969
16Hedgehog signaling pathway_Homo sapiens_hsa043401.41753639
17Amoebiasis_Homo sapiens_hsa051461.41024001
18Proteoglycans in cancer_Homo sapiens_hsa052051.41000277
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38628317
20Glutamatergic synapse_Homo sapiens_hsa047241.38327473
21Estrogen signaling pathway_Homo sapiens_hsa049151.37732635
22Basal cell carcinoma_Homo sapiens_hsa052171.36566429
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36015126
24Gastric acid secretion_Homo sapiens_hsa049711.35862343
25Thyroid cancer_Homo sapiens_hsa052161.34944480
26Protein digestion and absorption_Homo sapiens_hsa049741.33984913
27MicroRNAs in cancer_Homo sapiens_hsa052061.30737655
28GnRH signaling pathway_Homo sapiens_hsa049121.27052609
29TGF-beta signaling pathway_Homo sapiens_hsa043501.25550120
30Salivary secretion_Homo sapiens_hsa049701.25108362
31Synaptic vesicle cycle_Homo sapiens_hsa047211.23352563
32Rap1 signaling pathway_Homo sapiens_hsa040151.22795850
33Thyroid hormone synthesis_Homo sapiens_hsa049181.22712626
34Nicotine addiction_Homo sapiens_hsa050331.21612780
35Gap junction_Homo sapiens_hsa045401.17249077
36Choline metabolism in cancer_Homo sapiens_hsa052311.16366621
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15661635
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.14599486
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11949789
40Inositol phosphate metabolism_Homo sapiens_hsa005621.11550369
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11437813
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11287561
43Glioma_Homo sapiens_hsa052141.10806573
44Oxytocin signaling pathway_Homo sapiens_hsa049211.10211308
45Melanogenesis_Homo sapiens_hsa049161.10105804
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09962585
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.09750558
48Taste transduction_Homo sapiens_hsa047421.09314399
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07247232
50Pancreatic cancer_Homo sapiens_hsa052121.05625419
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04418361
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04285418
53Circadian entrainment_Homo sapiens_hsa047131.04073332
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03174592
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03104944
56Renal cell carcinoma_Homo sapiens_hsa052111.02045262
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01883249
58Prion diseases_Homo sapiens_hsa050201.01097608
59Endometrial cancer_Homo sapiens_hsa052131.00952020
60Ras signaling pathway_Homo sapiens_hsa040141.00559197
61Long-term potentiation_Homo sapiens_hsa047201.00024303
62cAMP signaling pathway_Homo sapiens_hsa040240.98407742
63Notch signaling pathway_Homo sapiens_hsa043300.97727684
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.97560660
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96100338
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95843643
67Wnt signaling pathway_Homo sapiens_hsa043100.95179378
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94589859
69Salmonella infection_Homo sapiens_hsa051320.94423748
70VEGF signaling pathway_Homo sapiens_hsa043700.93064974
71Renin secretion_Homo sapiens_hsa049240.91810885
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91511808
73Melanoma_Homo sapiens_hsa052180.88344901
74Pathways in cancer_Homo sapiens_hsa052000.87445776
75Cholinergic synapse_Homo sapiens_hsa047250.86736245
76Platelet activation_Homo sapiens_hsa046110.84580072
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82921322
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.82616872
79GABAergic synapse_Homo sapiens_hsa047270.82332917
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81677121
81ErbB signaling pathway_Homo sapiens_hsa040120.81607924
82Shigellosis_Homo sapiens_hsa051310.81458475
83Circadian rhythm_Homo sapiens_hsa047100.81185929
84MAPK signaling pathway_Homo sapiens_hsa040100.78349035
85Prostate cancer_Homo sapiens_hsa052150.78148698
86Colorectal cancer_Homo sapiens_hsa052100.78091449
87Morphine addiction_Homo sapiens_hsa050320.77443843
88Calcium signaling pathway_Homo sapiens_hsa040200.77198699
89Vibrio cholerae infection_Homo sapiens_hsa051100.76644445
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74665047
91Bile secretion_Homo sapiens_hsa049760.74225716
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.73812145
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72831445
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72714656
95Oocyte meiosis_Homo sapiens_hsa041140.71942433
96Dopaminergic synapse_Homo sapiens_hsa047280.71747691
97Pancreatic secretion_Homo sapiens_hsa049720.70435376
98Insulin secretion_Homo sapiens_hsa049110.70342558
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69400280
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69114127
101Bladder cancer_Homo sapiens_hsa052190.68729440
102Toxoplasmosis_Homo sapiens_hsa051450.68053187
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.68031838
104Mineral absorption_Homo sapiens_hsa049780.66578326
105Amphetamine addiction_Homo sapiens_hsa050310.64447478
106Endocytosis_Homo sapiens_hsa041440.64335449
107Serotonergic synapse_Homo sapiens_hsa047260.62560489
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61929253
109T cell receptor signaling pathway_Homo sapiens_hsa046600.61507326
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61441778
111Non-small cell lung cancer_Homo sapiens_hsa052230.61388124
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59865855
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59309695
114Hematopoietic cell lineage_Homo sapiens_hsa046400.59273968
115Antigen processing and presentation_Homo sapiens_hsa046120.59224031
116Chronic myeloid leukemia_Homo sapiens_hsa052200.58673504
117Prolactin signaling pathway_Homo sapiens_hsa049170.58650974
118Viral myocarditis_Homo sapiens_hsa054160.57730377
119mTOR signaling pathway_Homo sapiens_hsa041500.57473507
120Graft-versus-host disease_Homo sapiens_hsa053320.56833948
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54892732
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53795593
123Nitrogen metabolism_Homo sapiens_hsa009100.51285461

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