AFF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.36293321
2definitive hemopoiesis (GO:0060216)4.11784631
3regulation of gamma-delta T cell differentiation (GO:0045586)3.88996796
4negative regulation of erythrocyte differentiation (GO:0045647)3.87599126
5regulation of gamma-delta T cell activation (GO:0046643)3.77212398
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.68739474
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.68739474
8positive regulation by symbiont of host defense response (GO:0052509)3.67907916
9modulation by symbiont of host defense response (GO:0052031)3.67907916
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.67907916
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.67907916
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.67907916
13modulation by symbiont of host immune response (GO:0052553)3.67907916
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67904591
15positive regulation of histone deacetylation (GO:0031065)3.61855795
16antigen processing and presentation of endogenous antigen (GO:0019883)3.49964541
17negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.49725301
18negative regulation of T-helper cell differentiation (GO:0045623)3.49725301
19interkinetic nuclear migration (GO:0022027)3.34959932
20regulation of interferon-beta biosynthetic process (GO:0045357)3.20532559
21regulation of interleukin-12 biosynthetic process (GO:0045075)3.19879643
22histone H3-K4 trimethylation (GO:0080182)3.17809021
23JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.10897653
24macrophage activation involved in immune response (GO:0002281)3.09005903
25regulation of B cell receptor signaling pathway (GO:0050855)3.05192906
26positive regulation of B cell differentiation (GO:0045579)3.05155533
27negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.03399701
28regulation of RNA export from nucleus (GO:0046831)3.00219037
29histone lysine demethylation (GO:0070076)2.99431950
30positive regulation of p38MAPK cascade (GO:1900745)2.92622200
31response to muramyl dipeptide (GO:0032495)2.90690448
32regulation of necroptotic process (GO:0060544)2.89149611
33phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.87859765
34positive regulation of interferon-alpha production (GO:0032727)2.86625931
35pre-miRNA processing (GO:0031054)2.84849728
36histone demethylation (GO:0016577)2.80957819
37growth hormone receptor signaling pathway (GO:0060396)2.80540115
38regulation of T-helper 2 cell differentiation (GO:0045628)2.79218044
39positive regulation of granulocyte differentiation (GO:0030854)2.78929076
40cellular response to ethanol (GO:0071361)2.78891852
41iron ion import (GO:0097286)2.76532948
42regulation of interferon-alpha production (GO:0032647)2.76289006
43negative thymic T cell selection (GO:0045060)2.70943778
44detection of other organism (GO:0098543)2.70704720
45regulation of T-helper 1 cell differentiation (GO:0045625)2.69656848
46response to peptidoglycan (GO:0032494)2.68931773
47positive thymic T cell selection (GO:0045059)2.67399265
48neutrophil activation involved in immune response (GO:0002283)2.66840810
49cytoplasmic mRNA processing body assembly (GO:0033962)2.66234392
50mucosal-associated lymphoid tissue development (GO:0048537)2.65998511
51Peyers patch development (GO:0048541)2.65998511
52positive regulation of macrophage cytokine production (GO:0060907)2.65502521
53positive regulation of protein deacetylation (GO:0090312)2.64235518
54NIK/NF-kappaB signaling (GO:0038061)2.64012539
55response to laminar fluid shear stress (GO:0034616)2.63966509
56positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.63594365
57positive regulation of Rap GTPase activity (GO:0032854)2.63545935
58negative regulation of myotube differentiation (GO:0010832)2.62868240
59hypotonic response (GO:0006971)2.61651612
60histone H3-K4 methylation (GO:0051568)2.60089761
61regulation of nucleobase-containing compound transport (GO:0032239)2.59903035
62granulocyte activation (GO:0036230)2.59307276
63natural killer cell differentiation (GO:0001779)2.59152460
64negative regulation of type 2 immune response (GO:0002829)2.58715803
65neutrophil activation (GO:0042119)2.57155833
66hepatocyte apoptotic process (GO:0097284)2.56472223
67regulation of integrin activation (GO:0033623)2.56383718
68negative T cell selection (GO:0043383)2.54997017
69mature B cell differentiation involved in immune response (GO:0002313)2.54460586
70regulation of macrophage cytokine production (GO:0010935)2.54155655
71detection of bacterium (GO:0016045)2.53798828
72embryonic process involved in female pregnancy (GO:0060136)2.52303778
73immunoglobulin mediated immune response (GO:0016064)2.51190318
74detection of molecule of bacterial origin (GO:0032490)2.50776529
75thymic T cell selection (GO:0045061)2.50573991
76positive regulation of interferon-beta production (GO:0032728)2.49976658
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49863729
78regulation of protein polyubiquitination (GO:1902914)2.49827758
79leukocyte aggregation (GO:0070486)2.48717048
80regulation of B cell differentiation (GO:0045577)2.47805741
81negative regulation of stress fiber assembly (GO:0051497)2.45514248
82positive regulation of natural killer cell differentiation (GO:0032825)2.44951447
83detection of external biotic stimulus (GO:0098581)2.44670199
84apoptotic cell clearance (GO:0043277)2.44169784
85regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.42937316
86negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.42817236
87histone H3-K36 demethylation (GO:0070544)2.41747993
88negative regulation of interleukin-12 production (GO:0032695)2.41744269
89megakaryocyte development (GO:0035855)2.40889701
90B cell receptor signaling pathway (GO:0050853)2.40593865
91negative regulation of granulocyte differentiation (GO:0030853)2.39888113
92corticosteroid receptor signaling pathway (GO:0031958)2.38625655
93regulation of cholesterol storage (GO:0010885)2.38179443
94regulation of histone H3-K27 methylation (GO:0061085)2.37855335
95mature B cell differentiation (GO:0002335)2.36256286
96positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.35467325
97protein dealkylation (GO:0008214)2.34642353
98protein demethylation (GO:0006482)2.34642353
99cell adhesion mediated by integrin (GO:0033627)2.34368882
100cellular response to growth hormone stimulus (GO:0071378)2.34258954
101establishment of endothelial barrier (GO:0061028)2.33046017
102peptidyl-lysine trimethylation (GO:0018023)2.32641584
103leukocyte cell-cell adhesion (GO:0007159)2.32490525
104negative regulation of fatty acid transport (GO:2000192)2.31510059
105negative regulation of bone resorption (GO:0045779)2.31364272
106modulation by symbiont of host cellular process (GO:0044068)2.31223520
107low-density lipoprotein particle clearance (GO:0034383)2.31192911
108positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.30484027
109germinal center formation (GO:0002467)2.30249185
110negative regulation of B cell proliferation (GO:0030889)2.29928668
111trophectodermal cell differentiation (GO:0001829)2.29643747
112positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.29453194
113response to host immune response (GO:0052572)2.28874913
114response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.28874913
115cellular response to zinc ion (GO:0071294)2.27899624
116response to type I interferon (GO:0034340)2.27182153
117tolerance induction (GO:0002507)2.27155052
118regulation of granulocyte differentiation (GO:0030852)2.27150472
119response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.26683255
120response to host (GO:0075136)2.26683255
121response to host defenses (GO:0052200)2.26683255
122positive regulation of bone resorption (GO:0045780)2.25673308
123positive regulation of bone remodeling (GO:0046852)2.25673308
124negative regulation of phagocytosis (GO:0050765)2.25202223
125endothelium development (GO:0003158)2.24610578
126phospholipid translocation (GO:0045332)2.23329197
127lipid translocation (GO:0034204)2.23329197
128negative regulation of DNA repair (GO:0045738)2.23004013
129glucocorticoid receptor signaling pathway (GO:0042921)2.22949828
130carnitine shuttle (GO:0006853)2.22439373
131regulation of germinal center formation (GO:0002634)2.21978202
132embryonic placenta development (GO:0001892)2.21077342
133regulation of type I interferon-mediated signaling pathway (GO:0060338)2.20569078
134peptidyl-threonine phosphorylation (GO:0018107)2.20275064
135protein localization to endosome (GO:0036010)2.19906000
136pinocytosis (GO:0006907)2.18962702
137regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.18342816
138cellular response to interferon-alpha (GO:0035457)2.18032304
139histone H3-K9 demethylation (GO:0033169)2.17977402
140cellular extravasation (GO:0045123)2.17430859
141positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.16957081
142negative regulation of lipid storage (GO:0010888)2.16251207
143type I interferon signaling pathway (GO:0060337)2.15464770
144cellular response to type I interferon (GO:0071357)2.15464770
145T cell selection (GO:0045058)2.15453071
146positive regulation of leukocyte degranulation (GO:0043302)2.15118930
147negative regulation of interleukin-8 production (GO:0032717)2.14956250
148regulation of superoxide anion generation (GO:0032928)2.14341548
149lipopolysaccharide-mediated signaling pathway (GO:0031663)2.14335282
150positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.13753905
151negative regulation of toll-like receptor signaling pathway (GO:0034122)2.12631003
152myeloid dendritic cell differentiation (GO:0043011)2.12412163
153antigen processing and presentation via MHC class Ib (GO:0002475)2.11892702
154regulation of interferon-beta production (GO:0032648)2.10361725
155NLS-bearing protein import into nucleus (GO:0006607)2.08355238
156regulation of response to interferon-gamma (GO:0060330)2.07567688
157regulation of p38MAPK cascade (GO:1900744)2.06658938
158positive T cell selection (GO:0043368)2.06040678
159nuclear pore complex assembly (GO:0051292)2.05932553
160wound healing, spreading of epidermal cells (GO:0035313)2.05552068

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.74119246
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.57706664
3* EGR1_19374776_ChIP-ChIP_THP-1_Human3.33058445
4E2F7_22180533_ChIP-Seq_HELA_Human3.28937447
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.20815157
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.19525166
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.88853238
8MYC_22102868_ChIP-Seq_BL_Human2.81320240
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.65251854
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.62664603
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.56163844
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.48173854
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40119972
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28555249
15* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27161669
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27083598
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.23343711
18* VDR_21846776_ChIP-Seq_THP-1_Human2.22019244
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15968522
20* TCF7_22412390_ChIP-Seq_EML_Mouse2.03404195
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02295422
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99028727
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97952225
24* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.93952482
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.89727505
26* MAF_26560356_Chip-Seq_TH1_Human1.84080716
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82482495
28SCL_19346495_ChIP-Seq_HPC-7_Human1.81067073
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81063764
30MYB_26560356_Chip-Seq_TH2_Human1.79585446
31RUNX_20019798_ChIP-Seq_JUKART_Human1.78768302
32GATA1_22025678_ChIP-Seq_K562_Human1.78567687
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75107042
34* UTX_26944678_Chip-Seq_JUKART_Human1.70319713
35* MYB_26560356_Chip-Seq_TH1_Human1.66614368
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65306798
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63906787
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.63759342
39KDM2B_26808549_Chip-Seq_DND41_Human1.63291778
40* VDR_24763502_ChIP-Seq_THP-1_Human1.61731351
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60112413
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.59094513
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58898141
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58159357
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57783183
46* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57510634
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55962187
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54706462
49* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53238866
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51543679
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50558776
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.48559521
53* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48229496
54CLOCK_20551151_ChIP-Seq_293T_Human1.45619744
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40723453
56* SPI1_23127762_ChIP-Seq_K562_Human1.38260331
57SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35515479
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34834299
59* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32775132
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31632317
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.31175472
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30702531
63* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29511795
64TBX20_22328084_ChIP-Seq_HEART_Mouse1.28058745
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.28058745
66* FOXA2_19822575_ChIP-Seq_HepG2_Human1.27982037
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27149972
68NCOR1_26117541_ChIP-Seq_K562_Human1.24999959
69SPI1_23547873_ChIP-Seq_NB4_Human1.24832681
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.24769455
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23825147
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.21041003
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20854553
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19604523
75GATA1_19941827_ChIP-Seq_MEL86_Mouse1.19395205
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18779933
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18473742
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18298379
79GATA6_25053715_ChIP-Seq_YYC3_Human1.17982918
80* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17489328
81GATA1_19941826_ChIP-Seq_K562_Human1.16065387
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15873125
83PU_27001747_Chip-Seq_BMDM_Mouse1.15815079
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14905564
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14673409
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14655617
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.13232030
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13209202
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12236334
90GATA3_27048872_Chip-Seq_THYMUS_Human1.12063716
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11241168
92ATF3_27146783_Chip-Seq_COLON_Human1.10730074
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10573460
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10294078
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08849608
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08809122
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08151081
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08151081
99FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07470102
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07238533
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06874422
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.06718626
103RACK7_27058665_Chip-Seq_MCF-7_Human1.06628542
104* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06444151
105PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05620955
106* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04972287
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04346919
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04092944
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03630916
110PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03580392
111NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02863908
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.01359186
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01071375
114MAF_26560356_Chip-Seq_TH2_Human0.99039293
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99000778
116* GATA1_19941827_ChIP-Seq_MEL_Mouse0.98876339
117PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97950582
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.97849328
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97653301
120AR_21572438_ChIP-Seq_LNCaP_Human0.97563164
121TP53_16413492_ChIP-PET_HCT116_Human0.96145609
122* GATA2_19941826_ChIP-Seq_K562_Human0.95733649
123* LXR_22158963_ChIP-Seq_LIVER_Mouse0.95081140
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94856682
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94403724
126AHR_22903824_ChIP-Seq_MCF-7_Human0.93364953
127GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93220641
128* VDR_24787735_ChIP-Seq_THP-1_Human0.92949921
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92085868
130* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91482179
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90201013
132RUNX1_27514584_Chip-Seq_MCF-7_Human0.88952588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation2.83844153
2MP0010352_gastrointestinal_tract_polyps2.79034238
3MP0003300_gastrointestinal_ulcer2.76478461
4MP0005451_abnormal_body_composition2.42940369
5MP0003436_decreased_susceptibility_to2.38235796
6MP0005076_abnormal_cell_differentiation2.35660739
7MP0008057_abnormal_DNA_replication2.32581839
8MP0003705_abnormal_hypodermis_morpholog2.31122423
9MP0001835_abnormal_antigen_presentation2.28860689
10MP0002166_altered_tumor_susceptibility2.26540745
11MP0009278_abnormal_bone_marrow2.22971586
12MP0000685_abnormal_immune_system2.19386994
13MP0001790_abnormal_immune_system2.07448358
14MP0005387_immune_system_phenotype2.07448358
15MP0003566_abnormal_cell_adhesion2.04905415
16MP0001800_abnormal_humoral_immune1.90402414
17MP0004947_skin_inflammation1.89731261
18MP0002006_tumorigenesis1.83889456
19MP0002877_abnormal_melanocyte_morpholog1.79524910
20MP0005000_abnormal_immune_tolerance1.75587298
21MP0004130_abnormal_muscle_cell1.75098611
22MP0002452_abnormal_antigen_presenting1.73456136
23MP0010307_abnormal_tumor_latency1.67803360
24MP0001545_abnormal_hematopoietic_system1.60672832
25MP0005397_hematopoietic_system_phenotyp1.60672832
26MP0009785_altered_susceptibility_to1.59802675
27MP0010155_abnormal_intestine_physiology1.58917853
28MP0002419_abnormal_innate_immunity1.56558712
29MP0002405_respiratory_system_inflammati1.56303665
30MP0004808_abnormal_hematopoietic_stem1.54846637
31MP0002723_abnormal_immune_serum1.53204279
32MP0004036_abnormal_muscle_relaxation1.49876257
33MP0005025_abnormal_response_to1.49142951
34MP0005023_abnormal_wound_healing1.46020308
35MP0002420_abnormal_adaptive_immunity1.45621714
36MP0001819_abnormal_immune_cell1.45609189
37MP0005671_abnormal_response_to1.44243536
38* MP0002398_abnormal_bone_marrow1.42661528
39MP0005409_darkened_coat_color1.41428968
40MP0003453_abnormal_keratinocyte_physiol1.41406331
41MP0008004_abnormal_stomach_pH1.39154538
42MP0002396_abnormal_hematopoietic_system1.38413873
43MP0004185_abnormal_adipocyte_glucose1.37054136
44MP0006082_CNS_inflammation1.35615402
45MP0001533_abnormal_skeleton_physiology1.34215328
46MP0003045_fibrosis1.33014537
47MP0004510_myositis1.32446956
48MP0008438_abnormal_cutaneous_collagen1.32121948
49MP0003448_altered_tumor_morphology1.31981098
50MP0004084_abnormal_cardiac_muscle1.30019764
51* MP0000716_abnormal_immune_system1.29008674
52MP0004145_abnormal_muscle_electrophysio1.27916316
53MP0005058_abnormal_lysosome_morphology1.27362988
54MP0001853_heart_inflammation1.26617096
55MP0005375_adipose_tissue_phenotype1.25879733
56MP0005464_abnormal_platelet_physiology1.25318193
57MP0003763_abnormal_thymus_physiology1.25263042
58MP0000689_abnormal_spleen_morphology1.25247417
59MP0010368_abnormal_lymphatic_system1.24913274
60MP0003828_pulmonary_edema1.24097706
61MP0001845_abnormal_inflammatory_respons1.23714893
62* MP0002722_abnormal_immune_system1.22331495
63MP0003091_abnormal_cell_migration1.21326325
64MP0002060_abnormal_skin_morphology1.20287594
65MP0010234_abnormal_vibrissa_follicle1.19305684
66MP0002148_abnormal_hypersensitivity_rea1.18197396
67MP0003724_increased_susceptibility_to1.18195745
68MP0002254_reproductive_system_inflammat1.17508977
69MP0003191_abnormal_cellular_cholesterol1.17396617
70MP0006138_congestive_heart_failure1.14297389
71MP0000858_altered_metastatic_potential1.12424195
72MP0008961_abnormal_basal_metabolism1.10700452
73* MP0002429_abnormal_blood_cell1.10291996
74MP0005257_abnormal_intraocular_pressure1.09624415
75MP0001873_stomach_inflammation1.09219779
76MP0005310_abnormal_salivary_gland1.08857561
77MP0000465_gastrointestinal_hemorrhage1.08486283
78MP0008260_abnormal_autophagy1.06122183
79MP0000733_abnormal_muscle_development1.05601481
80* MP0000703_abnormal_thymus_morphology1.04383203
81MP0009333_abnormal_splenocyte_physiolog1.03306308
82MP0002998_abnormal_bone_remodeling1.02766881
83MP0003868_abnormal_feces_composition1.02020103
84MP0000490_abnormal_crypts_of1.01156708
85MP0005275_abnormal_skin_tensile1.00664764
86MP0002933_joint_inflammation0.99849894
87MP0003252_abnormal_bile_duct0.99845602
88MP0003172_abnormal_lysosome_physiology0.98695620
89MP0006054_spinal_hemorrhage0.98245816
90MP0002138_abnormal_hepatobiliary_system0.97370079
91MP0009840_abnormal_foam_cell0.97231442
92MP0005647_abnormal_sex_gland0.96401248
93MP0001849_ear_inflammation0.96077126
94MP0009697_abnormal_copulation0.95572422
95MP0004484_altered_response_of0.93089296
96MP0002796_impaired_skin_barrier0.92855423
97MP0000003_abnormal_adipose_tissue0.91879671
98MP0004381_abnormal_hair_follicle0.91677818
99MP0003279_aneurysm0.90734631
100MP0003183_abnormal_peptide_metabolism0.90012097
101MP0003943_abnormal_hepatobiliary_system0.89130586
102MP0002971_abnormal_brown_adipose0.88537646
103MP0005666_abnormal_adipose_tissue0.87995521
104MP0002019_abnormal_tumor_incidence0.85988284
105MP0004264_abnormal_extraembryonic_tissu0.84767375
106MP0002332_abnormal_exercise_endurance0.84536343
107MP0001216_abnormal_epidermal_layer0.83987061
108MP0004087_abnormal_muscle_fiber0.83733176
109MP0005220_abnormal_exocrine_pancreas0.82625107
110MP0005390_skeleton_phenotype0.82472938
111MP0003890_abnormal_embryonic-extraembry0.81692212
112MP0000767_abnormal_smooth_muscle0.81383765
113MP0001879_abnormal_lymphatic_vessel0.81188862
114MP0008469_abnormal_protein_level0.80777442
115MP0002009_preneoplasia0.80454990
116MP0001851_eye_inflammation0.80045879
117MP0002876_abnormal_thyroid_physiology0.79722474
118MP0003866_abnormal_defecation0.79370172
119MP0001915_intracranial_hemorrhage0.79166444
120MP0000343_altered_response_to0.78703292
121MP0002086_abnormal_extraembryonic_tissu0.78595780
122MP0000609_abnormal_liver_physiology0.78514206
123MP0003656_abnormal_erythrocyte_physiolo0.78385720
124MP0003984_embryonic_growth_retardation0.77000715
125MP0000350_abnormal_cell_proliferation0.76828224
126MP0000569_abnormal_digit_pigmentation0.76611573
127MP0009115_abnormal_fat_cell0.76295019
128MP0005621_abnormal_cell_physiology0.76264097
129MP0002136_abnormal_kidney_physiology0.75473663
130MP0010630_abnormal_cardiac_muscle0.75352824
131MP0001958_emphysema0.75310553
132MP0002088_abnormal_embryonic_growth/wei0.75060673
133MP0000249_abnormal_blood_vessel0.74563323
134MP0003646_muscle_fatigue0.74237997
135MP0009764_decreased_sensitivity_to0.73930810

Predicted human phenotypes

RankGene SetZ-score
1Recurrent viral infections (HP:0004429)3.54890314
2Abnormality of the fingertips (HP:0001211)3.49128320
3Eczematoid dermatitis (HP:0000976)3.43848597
4Cellulitis (HP:0100658)3.28259856
5Recurrent fungal infections (HP:0002841)3.21908134
6Autoimmune thrombocytopenia (HP:0001973)3.20663256
7Recurrent abscess formation (HP:0002722)3.03024824
8Acute myeloid leukemia (HP:0004808)2.97471627
9Pustule (HP:0200039)2.93010219
10Cerebral aneurysm (HP:0004944)2.88840541
11Overgrowth (HP:0001548)2.79646508
12Myocardial infarction (HP:0001658)2.78137592
13Autoimmune hemolytic anemia (HP:0001890)2.77927414
14Thyroiditis (HP:0100646)2.75412924
15Interstitial pulmonary disease (HP:0006530)2.71936842
16Recurrent bacterial skin infections (HP:0005406)2.71804018
17Dysmetric saccades (HP:0000641)2.71800924
18T lymphocytopenia (HP:0005403)2.68719407
19Ulnar bowing (HP:0003031)2.68017219
20Hematochezia (HP:0002573)2.66965292
21Abnormality of B cell number (HP:0010975)2.63805873
22B lymphocytopenia (HP:0010976)2.63805873
23Abnormality of T cell number (HP:0011839)2.58550506
24Eosinophilia (HP:0001880)2.54404516
25Colitis (HP:0002583)2.54369709
26Prolonged bleeding time (HP:0003010)2.51211496
27Papillary thyroid carcinoma (HP:0002895)2.48837384
28Neonatal hypoglycemia (HP:0001998)2.47209646
29Lip pit (HP:0100267)2.45446403
30Flat acetabular roof (HP:0003180)2.41936847
31Aortic aneurysm (HP:0004942)2.39146940
32Exercise-induced myalgia (HP:0003738)2.38179111
33Osteolytic defects of the hand bones (HP:0009699)2.37029899
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.37029899
35Abnormality of the left ventricular outflow tract (HP:0011103)2.31663965
36Subaortic stenosis (HP:0001682)2.31663965
37Hyperkalemia (HP:0002153)2.29392737
38Poikilocytosis (HP:0004447)2.28978820
39Verrucae (HP:0200043)2.28424395
40Papilloma (HP:0012740)2.28424395
41Difficulty running (HP:0009046)2.28015027
42Osteomyelitis (HP:0002754)2.27875816
43Panhypogammaglobulinemia (HP:0003139)2.26455873
44Mediastinal lymphadenopathy (HP:0100721)2.25419273
45Agammaglobulinemia (HP:0004432)2.24385707
46Centrally nucleated skeletal muscle fibers (HP:0003687)2.24019729
47Combined immunodeficiency (HP:0005387)2.23319370
48Epistaxis (HP:0000421)2.22122170
49Gingival bleeding (HP:0000225)2.22115130
50Periodontitis (HP:0000704)2.21674865
51Hyporeflexia of lower limbs (HP:0002600)2.20328887
52Increased density of long bones (HP:0006392)2.19454345
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17982411
54Abnormality of the axillary hair (HP:0100134)2.15237764
55Abnormality of secondary sexual hair (HP:0009888)2.15237764
56Right ventricular cardiomyopathy (HP:0011663)2.14619797
57Inflammation of the large intestine (HP:0002037)2.13511854
58Esophageal varix (HP:0002040)2.11481195
59Recurrent gram-negative bacterial infections (HP:0005420)2.10844738
60Leukocytosis (HP:0001974)2.10786701
61Gingivitis (HP:0000230)2.09780473
62Persistence of primary teeth (HP:0006335)2.07085195
63Meningitis (HP:0001287)2.05266717
64Increased connective tissue (HP:0009025)2.05061976
65Long eyelashes (HP:0000527)2.04714281
66Gastrointestinal inflammation (HP:0004386)2.03139327
67Severe combined immunodeficiency (HP:0004430)2.02398858
68Emphysema (HP:0002097)2.01719196
69Viral hepatitis (HP:0006562)2.01110389
70Muscle fiber inclusion bodies (HP:0100299)2.00603959
71Aneurysm (HP:0002617)2.00442259
72Granulocytopenia (HP:0001913)1.98254774
73Pigmentary retinal degeneration (HP:0001146)1.96560746
74Nemaline bodies (HP:0003798)1.96271015
75Myositis (HP:0100614)1.96190630
76Vasculitis (HP:0002633)1.93967191
77Abnormality of macrophages (HP:0004311)1.93373334
78Acute lymphatic leukemia (HP:0006721)1.91477790
79Muscle hypertrophy of the lower extremities (HP:0008968)1.91312446
80Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.91187927
81Orchitis (HP:0100796)1.90693984
82Increased IgE level (HP:0003212)1.89603753
83Peritonitis (HP:0002586)1.89079276
84Muscle fiber splitting (HP:0003555)1.87926125
85Arterial thrombosis (HP:0004420)1.87108647
86Broad face (HP:0000283)1.86978315
87Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86697734
88Calf muscle hypertrophy (HP:0008981)1.86664047
89Abnormality of T cells (HP:0002843)1.86235913
90Hypoplasia of the thymus (HP:0000778)1.86131754
91Abnormality of eosinophils (HP:0001879)1.85963979
92Abnormality of the columella (HP:0009929)1.85909569
93Sparse lateral eyebrow (HP:0005338)1.85405311
94Recurrent bronchitis (HP:0002837)1.83495212
95Fatigue (HP:0012378)1.83194045
96Narrow palate (HP:0000189)1.81129604
97Recurrent skin infections (HP:0001581)1.80836715
98Hyperactive renin-angiotensin system (HP:0000841)1.80063760
99Abnormality of chloride homeostasis (HP:0011422)1.78700106
100Cervical subluxation (HP:0003308)1.77701740
101Dilatation of the ascending aorta (HP:0005111)1.77310971
102Mitral valve prolapse (HP:0001634)1.77120522
103Macroorchidism (HP:0000053)1.76230740
104Testicular neoplasm (HP:0010788)1.75873404
105Ankyloglossia (HP:0010296)1.75451083
106Acanthocytosis (HP:0001927)1.75423541
107Abnormal delayed hypersensitivity skin test (HP:0002963)1.75380291
108Anal stenosis (HP:0002025)1.74971279
109IgA deficiency (HP:0002720)1.74617559
110Chronic otitis media (HP:0000389)1.74466335
111Asymmetric septal hypertrophy (HP:0001670)1.74112240
112Pulmonary infiltrates (HP:0002113)1.73852298
113Recurrent cutaneous fungal infections (HP:0011370)1.73178220
114Chronic mucocutaneous candidiasis (HP:0002728)1.73178220
115Premature rupture of membranes (HP:0001788)1.73019329
116Gastrointestinal infarctions (HP:0005244)1.72379719
117Thick nail (HP:0001805)1.72240413
118Premature loss of primary teeth (HP:0006323)1.72220936
119Thyroid carcinoma (HP:0002890)1.71692464
120Increased cerebral lipofuscin (HP:0011813)1.70979596
121IgM deficiency (HP:0002850)1.70645164
122Skin ulcer (HP:0200042)1.70390236
123Limited elbow extension (HP:0001377)1.69906580
124Ankle contracture (HP:0006466)1.69890161
125Sepsis (HP:0100806)1.69703935
126Spontaneous hematomas (HP:0007420)1.67990636
127Metaphyseal cupping (HP:0003021)1.67466318
128Restrictive lung disease (HP:0002091)1.66390375
129Polycythemia (HP:0001901)1.65913559
130Abnormality of skeletal muscle fiber size (HP:0012084)1.65873219
131Aortic dissection (HP:0002647)1.65837681
132Slow saccadic eye movements (HP:0000514)1.64980691
133Prostate neoplasm (HP:0100787)1.64348442
134Truncal obesity (HP:0001956)1.64186701
135Thickened calvaria (HP:0002684)1.64122131
136Increased circulating renin level (HP:0000848)1.64105347
137Abnormal platelet volume (HP:0011876)1.63811182
138Urethral obstruction (HP:0000796)1.63191827
139Protrusio acetabuli (HP:0003179)1.62899545
140Spondylolisthesis (HP:0003302)1.62350560
141Lymphopenia (HP:0001888)1.59398891
142Craniofacial hyperostosis (HP:0004493)1.58996966
143Nasal polyposis (HP:0100582)1.58709424
144Germ cell neoplasia (HP:0100728)1.57088085
145Tibial bowing (HP:0002982)1.56661078
146Chest pain (HP:0100749)1.56593729
147Cranial hyperostosis (HP:0004437)1.55624830
148Abnormal platelet function (HP:0011869)1.55530660
149Small epiphyses (HP:0010585)1.55306464
150Bowing of the arm (HP:0006488)1.54893545
151Bowed forearm bones (HP:0003956)1.54893545
152Abnormality of cells of the lymphoid lineage (HP:0012140)1.54657528
153Increased mean platelet volume (HP:0011877)1.54017405
154Prominent nose (HP:0000448)1.53261834
155Abnormality of the nasal mucosa (HP:0000433)1.53104179
156Subacute progressive viral hepatitis (HP:0006572)1.52905120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.88858744
2CDK123.64463607
3ERN13.45528966
4AKT32.59714836
5MAP4K12.58474484
6PRPF4B2.37003317
7EEF2K2.33800243
8TRIB32.31456421
9STK102.17687197
10TYK21.91945631
11TTN1.82126521
12TAOK31.79304405
13EPHB11.71446024
14CAMK1D1.68761258
15MAP3K141.67555682
16SGK21.65882241
17LATS11.63532610
18JAK11.61040228
19JAK31.57323010
20TNK21.54832431
21WNK11.54712326
22FGFR31.51685758
23OBSCN1.50072942
24TRPM71.46661862
25GRK61.44654435
26IRAK31.44346810
27TBK11.42330285
28PKN21.42222790
29SIK11.42098482
30TGFBR21.41335348
31MARK21.39559760
32STK31.37079903
33MAP3K131.36195409
34PIK3CG1.35556645
35FGFR41.34334267
36PIM11.31538232
37CSK1.28914545
38CHUK1.28018792
39IKBKB1.26316061
40STK41.24629148
41PTK61.23210422
42LRRK21.20844847
43CDK61.19004574
44RPS6KA41.13446607
45CAMK1G1.12607311
46CDC42BPA1.10255547
47MAP3K31.09533377
48ZAP701.07364307
49RIPK11.04896586
50IKBKE1.04189851
51BMX1.02994029
52MAP2K31.00392283
53HCK0.98786028
54SGK4940.97971970
55SGK2230.97971970
56MAP3K20.97957073
57MTOR0.96683405
58SMG10.96080953
59CSF1R0.93676505
60CDK90.92182130
61NEK20.91445780
62EPHA30.91175220
63PDGFRB0.91055607
64ITK0.89952443
65JAK20.89058023
66CDK40.88783423
67BTK0.86103542
68FES0.86039528
69FRK0.85806494
70HIPK20.85616175
71DMPK0.85150271
72MAPK120.84353314
73BMPR20.83839498
74TXK0.83422475
75TAOK10.83277369
76MAP3K10.83222553
77RPS6KB20.82343533
78NEK90.80815923
79YES10.80271342
80FER0.80078935
81PDGFRA0.79066242
82SYK0.76586030
83IRAK40.75840770
84MAPKAPK30.74651720
85BRD40.74446785
86BLK0.73652592
87EPHA20.71534592
88MAP3K80.71261122
89SCYL20.70727109
90RIPK40.69898922
91MST40.68811831
92MARK30.66781478
93MST1R0.65464941
94LCK0.65255737
95MAP3K60.64377764
96IRAK10.63919914
97DYRK1B0.63558350
98MAPK110.59564108
99KIT0.59104415
100SGK30.58559631
101SIK20.57067002
102MAP3K70.56185571
103PRKD20.55803186
104PDK10.55193383
105MELK0.55164366
106PRKAA20.54716396
107RET0.53668091
108SGK10.53245999
109RPS6KC10.50739809
110RPS6KL10.50739809
111MATK0.49945865
112ACVR1B0.49710471
113NLK0.49627295
114STK240.48850305
115ABL10.48795675
116ALK0.47455573
117TEC0.47149099
118FLT30.46695395
119PRKAA10.46264861
120PDPK10.45477850
121CAMK40.45386318
122MAPK70.44995117
123MAPKAPK20.44126457
124PAK40.43846937
125EGFR0.43532559
126PAK20.43085288
127ICK0.42808921
128LYN0.40925605
129PIM20.40206950
130PRKD10.39663312
131PIK3CA0.37823584
132GSK3A0.37663522

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.35882022
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.35363369
3Primary immunodeficiency_Homo sapiens_hsa053402.19105388
4Osteoclast differentiation_Homo sapiens_hsa043802.17388847
5B cell receptor signaling pathway_Homo sapiens_hsa046622.13777890
6Chronic myeloid leukemia_Homo sapiens_hsa052201.77862168
7Toxoplasmosis_Homo sapiens_hsa051451.69777802
8Measles_Homo sapiens_hsa051621.66770649
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65787939
10Small cell lung cancer_Homo sapiens_hsa052221.64260015
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.58147056
12TNF signaling pathway_Homo sapiens_hsa046681.51663935
13Hematopoietic cell lineage_Homo sapiens_hsa046401.46158889
14Acute myeloid leukemia_Homo sapiens_hsa052211.45637831
15Malaria_Homo sapiens_hsa051441.44797528
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42929058
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.42544395
18Influenza A_Homo sapiens_hsa051641.41194406
19Herpes simplex infection_Homo sapiens_hsa051681.40311192
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40132851
21Pancreatic cancer_Homo sapiens_hsa052121.39163302
22Autoimmune thyroid disease_Homo sapiens_hsa053201.38428074
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.37997184
24Apoptosis_Homo sapiens_hsa042101.36926154
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36793117
26Lysine degradation_Homo sapiens_hsa003101.36663041
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35859729
28Tuberculosis_Homo sapiens_hsa051521.33925913
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.32564056
30Legionellosis_Homo sapiens_hsa051341.32043886
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29148268
32Hepatitis B_Homo sapiens_hsa051611.28902240
33Antigen processing and presentation_Homo sapiens_hsa046121.28868228
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.27551796
35Adherens junction_Homo sapiens_hsa045201.26808385
36MicroRNAs in cancer_Homo sapiens_hsa052061.24588248
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24507459
38mTOR signaling pathway_Homo sapiens_hsa041501.21834420
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21735958
40Staphylococcus aureus infection_Homo sapiens_hsa051501.21478942
41Circadian rhythm_Homo sapiens_hsa047101.19359468
42Insulin resistance_Homo sapiens_hsa049311.18708788
43Ovarian steroidogenesis_Homo sapiens_hsa049131.16576421
44T cell receptor signaling pathway_Homo sapiens_hsa046601.15344733
45Proteoglycans in cancer_Homo sapiens_hsa052051.12564239
46Viral myocarditis_Homo sapiens_hsa054161.12010392
47Viral carcinogenesis_Homo sapiens_hsa052031.10624348
48* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08143628
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07490051
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02696480
51Amoebiasis_Homo sapiens_hsa051461.02160351
52Focal adhesion_Homo sapiens_hsa045101.01730145
53Notch signaling pathway_Homo sapiens_hsa043301.01184699
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.00442503
55p53 signaling pathway_Homo sapiens_hsa041151.00054365
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97582663
57Chemokine signaling pathway_Homo sapiens_hsa040620.97379565
58Pertussis_Homo sapiens_hsa051330.97346803
59FoxO signaling pathway_Homo sapiens_hsa040680.96499690
60Shigellosis_Homo sapiens_hsa051310.96447843
61Hepatitis C_Homo sapiens_hsa051600.96229454
62Thyroid hormone synthesis_Homo sapiens_hsa049180.95436955
63Prostate cancer_Homo sapiens_hsa052150.95135271
64GnRH signaling pathway_Homo sapiens_hsa049120.94305684
65Non-small cell lung cancer_Homo sapiens_hsa052230.93704518
66Insulin signaling pathway_Homo sapiens_hsa049100.93688127
67Lysosome_Homo sapiens_hsa041420.91810517
68Prolactin signaling pathway_Homo sapiens_hsa049170.90695987
69HTLV-I infection_Homo sapiens_hsa051660.90067707
70Bladder cancer_Homo sapiens_hsa052190.89798584
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.88162719
72ECM-receptor interaction_Homo sapiens_hsa045120.87485772
73Platelet activation_Homo sapiens_hsa046110.85776616
74Fatty acid biosynthesis_Homo sapiens_hsa000610.85023550
75Choline metabolism in cancer_Homo sapiens_hsa052310.85022182
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80854322
77HIF-1 signaling pathway_Homo sapiens_hsa040660.79887247
78Dorso-ventral axis formation_Homo sapiens_hsa043200.79736029
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.79475766
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78518364
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76673687
82Salmonella infection_Homo sapiens_hsa051320.75789700
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75787558
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.75418762
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.74730043
86Caffeine metabolism_Homo sapiens_hsa002320.73441224
87Type II diabetes mellitus_Homo sapiens_hsa049300.72712592
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70804204
89ErbB signaling pathway_Homo sapiens_hsa040120.70504268
90Endometrial cancer_Homo sapiens_hsa052130.69362606
91Type I diabetes mellitus_Homo sapiens_hsa049400.69329755
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69105442
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68352148
94Pancreatic secretion_Homo sapiens_hsa049720.67990605
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67362739
96VEGF signaling pathway_Homo sapiens_hsa043700.65398806
97Other glycan degradation_Homo sapiens_hsa005110.65267558
98ABC transporters_Homo sapiens_hsa020100.65084271
99Glucagon signaling pathway_Homo sapiens_hsa049220.63958789
100Allograft rejection_Homo sapiens_hsa053300.63519985
101Colorectal cancer_Homo sapiens_hsa052100.63317213
102Phototransduction_Homo sapiens_hsa047440.63281991
103Renal cell carcinoma_Homo sapiens_hsa052110.62390860
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61081201
105Estrogen signaling pathway_Homo sapiens_hsa049150.59551788
106Long-term potentiation_Homo sapiens_hsa047200.59309957
107Renin-angiotensin system_Homo sapiens_hsa046140.59228711
108African trypanosomiasis_Homo sapiens_hsa051430.57925374
109TGF-beta signaling pathway_Homo sapiens_hsa043500.57906013
110Pathways in cancer_Homo sapiens_hsa052000.57061545
111Inositol phosphate metabolism_Homo sapiens_hsa005620.56626948
112Epstein-Barr virus infection_Homo sapiens_hsa051690.56241789
113Systemic lupus erythematosus_Homo sapiens_hsa053220.55959366
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55772236
115Dilated cardiomyopathy_Homo sapiens_hsa054140.55306857
116Graft-versus-host disease_Homo sapiens_hsa053320.55224556
117AMPK signaling pathway_Homo sapiens_hsa041520.53311002
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50187849
119Glioma_Homo sapiens_hsa052140.49947696
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.49890311
121Asthma_Homo sapiens_hsa053100.49616786
122Thyroid cancer_Homo sapiens_hsa052160.49048191
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46634009
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45596448

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