AFF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative transcriptional activator that is a member of the AF4FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation. In addition, this gene contains 6-25 GCC repeats that are expanded to >200 repeats in the disease state. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase catabolic process (GO:0046113)4.82438659
2neuron cell-cell adhesion (GO:0007158)4.39580316
3neurotransmitter-gated ion channel clustering (GO:0072578)4.21047195
4axonal fasciculation (GO:0007413)4.05986030
5layer formation in cerebral cortex (GO:0021819)4.04594794
6vocalization behavior (GO:0071625)4.03621776
7establishment of mitochondrion localization (GO:0051654)3.92059132
8synaptic vesicle maturation (GO:0016188)3.86955924
9neuron recognition (GO:0008038)3.70909562
10central nervous system projection neuron axonogenesis (GO:0021952)3.70905398
11protein localization to synapse (GO:0035418)3.70344890
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69984076
13negative regulation of cytosolic calcium ion concentration (GO:0051481)3.68713090
14synaptic vesicle endocytosis (GO:0048488)3.64250759
15dendrite morphogenesis (GO:0048813)3.54178204
16regulation of short-term neuronal synaptic plasticity (GO:0048172)3.53150926
17positive regulation of dendritic spine morphogenesis (GO:0061003)3.46643168
18neuron-neuron synaptic transmission (GO:0007270)3.42135095
19adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.40732314
20chondrocyte proliferation (GO:0035988)3.32093522
21pyrimidine nucleobase catabolic process (GO:0006208)3.28430550
22mitochondrion transport along microtubule (GO:0047497)3.27544967
23establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.27544967
24synaptic vesicle exocytosis (GO:0016079)3.25742397
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.24113678
26exploration behavior (GO:0035640)3.22414599
27negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.17308276
28negative regulation of DNA-templated transcription, elongation (GO:0032785)3.17308276
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.17066691
30behavioral response to nicotine (GO:0035095)3.17000686
31transmission of nerve impulse (GO:0019226)3.16865833
32locomotory exploration behavior (GO:0035641)3.15322362
33adult walking behavior (GO:0007628)3.13959941
34startle response (GO:0001964)3.13606363
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12611439
36regulation of synaptic transmission, glutamatergic (GO:0051966)3.10937562
37cerebral cortex radially oriented cell migration (GO:0021799)3.08677402
38central nervous system neuron axonogenesis (GO:0021955)3.08646030
39cerebellar granule cell differentiation (GO:0021707)3.07551623
40cell migration in hindbrain (GO:0021535)3.06993662
41postsynaptic membrane organization (GO:0001941)3.06695194
42forebrain neuron differentiation (GO:0021879)3.06471126
43cerebral cortex neuron differentiation (GO:0021895)3.05100975
44response to auditory stimulus (GO:0010996)3.03506387
45auditory behavior (GO:0031223)3.03193868
46regulation of synaptic vesicle exocytosis (GO:2000300)3.02581740
47negative regulation of oligodendrocyte differentiation (GO:0048715)3.00079085
48cranial nerve morphogenesis (GO:0021602)2.99330804
49regulation of excitatory postsynaptic membrane potential (GO:0060079)2.98654526
50somite development (GO:0061053)2.98170072
51spinal cord development (GO:0021510)2.97564527
52dendritic spine morphogenesis (GO:0060997)2.96249314
53gamma-aminobutyric acid transport (GO:0015812)2.95955571
54behavioral defense response (GO:0002209)2.95668610
55behavioral fear response (GO:0001662)2.95668610
56limb bud formation (GO:0060174)2.95569790
57regulation of glutamate receptor signaling pathway (GO:1900449)2.95552632
58fucosylation (GO:0036065)2.95099711
59positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.92799404
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92609667
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90779327
62RNA localization (GO:0006403)2.90122956
63membrane depolarization during action potential (GO:0086010)2.89285022
64presynaptic membrane assembly (GO:0097105)2.89271567
65regulation of neuronal synaptic plasticity (GO:0048168)2.88177509
66interkinetic nuclear migration (GO:0022027)2.87357356
67neuronal stem cell maintenance (GO:0097150)2.87121211
68cerebellar Purkinje cell differentiation (GO:0021702)2.86833283
69positive regulation of synapse assembly (GO:0051965)2.86134547
70cerebral cortex cell migration (GO:0021795)2.85523395
71ionotropic glutamate receptor signaling pathway (GO:0035235)2.85515240
72cellular response to prostaglandin stimulus (GO:0071379)2.84889002
73regulation of postsynaptic membrane potential (GO:0060078)2.84310996
74regulation of synapse assembly (GO:0051963)2.84120800
75nerve growth factor signaling pathway (GO:0038180)2.83390582
76neurotransmitter secretion (GO:0007269)2.81353690
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80713351
78positive regulation of synapse maturation (GO:0090129)2.80614324
79regulation of dendritic spine morphogenesis (GO:0061001)2.80492611
80stress granule assembly (GO:0034063)2.77968483
81neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.77424873
82neuronal action potential propagation (GO:0019227)2.77200684
83atrial cardiac muscle cell action potential (GO:0086014)2.76829274
84central nervous system neuron development (GO:0021954)2.76020226
85regulation of synaptic vesicle transport (GO:1902803)2.75670216
86substrate-independent telencephalic tangential migration (GO:0021826)2.75224768
87substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.75224768
88retinal ganglion cell axon guidance (GO:0031290)2.75111961
89forebrain neuron development (GO:0021884)2.74779518
90cochlea development (GO:0090102)2.74529512
91regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74092027
92synapse assembly (GO:0007416)2.73099786
93negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.71692814
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71089222
95cerebellum development (GO:0021549)2.70743606
96detection of calcium ion (GO:0005513)2.70330212
97olfactory bulb development (GO:0021772)2.70065861
98positive regulation of dendrite morphogenesis (GO:0050775)2.69671827
99presynaptic membrane organization (GO:0097090)2.69622518
100epithelial cell differentiation involved in kidney development (GO:0035850)2.68527470
101innervation (GO:0060384)2.68231598
102calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.67882634
103suckling behavior (GO:0001967)2.67015083
104mechanosensory behavior (GO:0007638)2.66687371
105membrane depolarization (GO:0051899)2.65072966
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.64953573
107positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.62285678
108heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.61108927
109regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.61107432
110sympathetic nervous system development (GO:0048485)2.60594743
111proline transport (GO:0015824)2.60142823
112glutamate secretion (GO:0014047)2.56579866
113regulation of synapse structural plasticity (GO:0051823)2.56548632
114axonogenesis (GO:0007409)2.55885304
115positive regulation of axon extension (GO:0045773)2.55799658
116establishment of nucleus localization (GO:0040023)2.55201437
117synaptic transmission, glutamatergic (GO:0035249)2.54174019
118nucleus localization (GO:0051647)2.53915406
119dendrite development (GO:0016358)2.52769694
120cAMP-mediated signaling (GO:0019933)2.52708094
121neuron migration (GO:0001764)2.51711188
122striatum development (GO:0021756)2.51447223
123hippocampus development (GO:0021766)2.51362073
124cell communication by electrical coupling (GO:0010644)2.50879236
125regulation of synapse organization (GO:0050807)2.50514888
126long-term memory (GO:0007616)2.50323643
127receptor recycling (GO:0001881)2.49905152
128female gonad development (GO:0008585)2.49409593
129negative regulation of axon extension involved in axon guidance (GO:0048843)2.49041981
130regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.48432582
131cerebellar Purkinje cell layer development (GO:0021680)2.47557587
132regulation of axon extension (GO:0030516)2.46271356
133regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.45908772
134axon extension (GO:0048675)2.44393963
135glutamate receptor signaling pathway (GO:0007215)2.43600350
136N-glycan processing (GO:0006491)2.42853022
137eye photoreceptor cell differentiation (GO:0001754)2.41916630
138photoreceptor cell differentiation (GO:0046530)2.41916630
139urogenital system development (GO:0001655)2.40637316
140regulation of neuron migration (GO:2001222)2.40481052
141regulation of axon extension involved in axon guidance (GO:0048841)2.40284756
142urinary tract smooth muscle contraction (GO:0014848)2.39675521
143regulation of synapse maturation (GO:0090128)2.39394719
144histamine secretion (GO:0001821)2.39184606
145synapse organization (GO:0050808)2.37906834
146positive regulation of synaptic transmission, GABAergic (GO:0032230)2.37744067
147response to pheromone (GO:0019236)11.2748326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.51530736
2GBX2_23144817_ChIP-Seq_PC3_Human4.80855723
3* EZH2_27304074_Chip-Seq_ESCs_Mouse3.05460928
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78912101
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74346351
6IGF1R_20145208_ChIP-Seq_DFB_Human2.71790449
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50917805
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50917805
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.49094215
10* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48316570
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46191708
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45916035
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45751966
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37489677
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25477597
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25055889
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24751053
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.17352741
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14711665
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.13213446
21TAF15_26573619_Chip-Seq_HEK293_Human2.10736559
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04462039
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02994512
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01719653
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.01180362
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.00213436
27REST_21632747_ChIP-Seq_MESCs_Mouse1.98938861
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95554589
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94871768
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94412734
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.93185191
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91987945
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.88896330
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79760374
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77452696
36DROSHA_22980978_ChIP-Seq_HELA_Human1.74927325
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73561365
38P300_19829295_ChIP-Seq_ESCs_Human1.69757924
39AR_21572438_ChIP-Seq_LNCaP_Human1.69750187
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63684613
41RNF2_27304074_Chip-Seq_NSC_Mouse1.63640694
42SMAD4_21799915_ChIP-Seq_A2780_Human1.63480096
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62689714
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60434796
45ZNF274_21170338_ChIP-Seq_K562_Hela1.59397046
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56123482
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51355868
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.46359480
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45739321
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.42805745
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38409301
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36178191
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36002264
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35069597
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.33343743
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31276901
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31264578
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29048020
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.28001079
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.26648469
61STAT3_23295773_ChIP-Seq_U87_Human1.24759128
62FUS_26573619_Chip-Seq_HEK293_Human1.23873457
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.22712305
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22427251
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.21934672
66SOX9_26525672_Chip-Seq_HEART_Mouse1.21587095
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.20386290
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19835868
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19740126
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.18733010
71AHR_22903824_ChIP-Seq_MCF-7_Human1.18336238
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18184515
73VDR_22108803_ChIP-Seq_LS180_Human1.18006414
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.16894165
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16358481
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16075016
77* AR_19668381_ChIP-Seq_PC3_Human1.15999966
78* TCF4_23295773_ChIP-Seq_U87_Human1.15598116
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15192756
80AR_25329375_ChIP-Seq_VCAP_Human1.15151003
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15140437
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14925541
83* RUNX2_22187159_ChIP-Seq_PCA_Human1.14886326
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14752617
85CBP_20019798_ChIP-Seq_JUKART_Human1.14234515
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14234515
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13599349
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12248510
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.12023767
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.11832834
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11069686
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10853562
93EWS_26573619_Chip-Seq_HEK293_Human1.10836270
94GATA1_26923725_Chip-Seq_HPCs_Mouse1.09122990
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08485956
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07951329
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07897350
98ER_23166858_ChIP-Seq_MCF-7_Human1.07597307
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06750244
100TP53_16413492_ChIP-PET_HCT116_Human1.05772216
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04814256
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.04764226
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.04386186
104KDM2B_26808549_Chip-Seq_REH_Human1.04369276
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04348436
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03657388
107P53_22387025_ChIP-Seq_ESCs_Mouse1.03012179
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02840974
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02039222
110TP53_20018659_ChIP-ChIP_R1E_Mouse1.00717051
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00366038
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00366038
113SMAD_19615063_ChIP-ChIP_OVARY_Human0.99480398
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99469710
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98801917
116SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97718451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.58148231
2MP0004859_abnormal_synaptic_plasticity3.38144457
3MP0000569_abnormal_digit_pigmentation3.23889569
4MP0003121_genomic_imprinting3.17100436
5MP0006276_abnormal_autonomic_nervous3.08860379
6MP0003880_abnormal_central_pattern2.78651962
7MP0000778_abnormal_nervous_system2.44719552
8MP0002822_catalepsy2.39768201
9MP0002102_abnormal_ear_morphology2.36905776
10MP0005645_abnormal_hypothalamus_physiol2.35336810
11MP0004270_analgesia2.33791493
12* MP0003635_abnormal_synaptic_transmissio2.29773951
13MP0000566_synostosis2.23346069
14MP0005646_abnormal_pituitary_gland2.14162813
15* MP0002063_abnormal_learning/memory/cond2.14017767
16MP0003787_abnormal_imprinting2.09644423
17MP0005423_abnormal_somatic_nervous1.97790941
18MP0009780_abnormal_chondrocyte_physiolo1.95687358
19MP0001984_abnormal_olfaction1.89920810
20MP0000631_abnormal_neuroendocrine_gland1.87638696
21MP0003890_abnormal_embryonic-extraembry1.86665966
22MP0002557_abnormal_social/conspecific_i1.84339413
23MP0005187_abnormal_penis_morphology1.83782395
24MP0010030_abnormal_orbit_morphology1.81483627
25MP0006292_abnormal_olfactory_placode1.75666455
26MP0008995_early_reproductive_senescence1.75531096
27MP0002876_abnormal_thyroid_physiology1.73703117
28MP0002572_abnormal_emotion/affect_behav1.71892296
29MP0001968_abnormal_touch/_nociception1.69988972
30MP0009046_muscle_twitch1.66841010
31MP0002064_seizures1.66251652
32MP0010386_abnormal_urinary_bladder1.65404241
33MP0009745_abnormal_behavioral_response1.64925407
34MP0001440_abnormal_grooming_behavior1.62091691
35MP0002653_abnormal_ependyma_morphology1.61100832
36MP0002184_abnormal_innervation1.59621565
37MP0002734_abnormal_mechanical_nocicepti1.56425106
38MP0001486_abnormal_startle_reflex1.51430723
39MP0003385_abnormal_body_wall1.49867228
40MP0004885_abnormal_endolymph1.49596386
41MP0003123_paternal_imprinting1.46749444
42MP0003136_yellow_coat_color1.44872405
43MP0001299_abnormal_eye_distance/1.42744567
44MP0003137_abnormal_impulse_conducting1.40136033
45MP0002735_abnormal_chemical_nociception1.35372725
46MP0002638_abnormal_pupillary_reflex1.34783796
47MP0002751_abnormal_autonomic_nervous1.33571169
48MP0008057_abnormal_DNA_replication1.32222781
49MP0000681_abnormal_thyroid_gland1.29643011
50* MP0001970_abnormal_pain_threshold1.28809354
51MP0004742_abnormal_vestibular_system1.28790229
52MP0004811_abnormal_neuron_physiology1.28574165
53* MP0002733_abnormal_thermal_nociception1.27903831
54MP0003315_abnormal_perineum_morphology1.27621989
55MP0001188_hyperpigmentation1.27370978
56MP0002067_abnormal_sensory_capabilities1.27009874
57MP0008789_abnormal_olfactory_epithelium1.26622498
58MP0001502_abnormal_circadian_rhythm1.26006735
59MP0002909_abnormal_adrenal_gland1.22927390
60MP0008877_abnormal_DNA_methylation1.22457632
61MP0003938_abnormal_ear_development1.20455345
62MP0000538_abnormal_urinary_bladder1.20207832
63MP0002272_abnormal_nervous_system1.18725786
64MP0000537_abnormal_urethra_morphology1.18378929
65MP0000955_abnormal_spinal_cord1.17081357
66MP0002938_white_spotting1.16937002
67MP0002736_abnormal_nociception_after1.16841459
68MP0005248_abnormal_Harderian_gland1.16239368
69MP0000049_abnormal_middle_ear1.13703418
70MP0003755_abnormal_palate_morphology1.12790215
71MP0005503_abnormal_tendon_morphology1.11943736
72MP0005499_abnormal_olfactory_system1.09785632
73MP0005394_taste/olfaction_phenotype1.09785632
74MP0003283_abnormal_digestive_organ1.08261250
75MP0008569_lethality_at_weaning1.08098553
76MP0002882_abnormal_neuron_morphology1.07838661
77MP0005386_behavior/neurological_phenoty1.07420444
78MP0004924_abnormal_behavior1.07420444
79MP0005409_darkened_coat_color1.04534670
80MP0000534_abnormal_ureter_morphology1.03999345
81MP0003633_abnormal_nervous_system1.03639915
82MP0005171_absent_coat_pigmentation1.03599564
83MP0002152_abnormal_brain_morphology1.01835287
84MP0002249_abnormal_larynx_morphology1.01511272
85MP0003631_nervous_system_phenotype1.00215007
86MP0003942_abnormal_urinary_system0.98844850
87MP0003091_abnormal_cell_migration0.97233671
88MP0003632_abnormal_nervous_system0.95786967
89MP0004133_heterotaxia0.95492607
90MP0004145_abnormal_muscle_electrophysio0.94484516
91MP0001963_abnormal_hearing_physiology0.93963032
92MP0002009_preneoplasia0.93829387
93MP0002116_abnormal_craniofacial_bone0.93403756
94MP0009250_abnormal_appendicular_skeleto0.93002427
95MP0001293_anophthalmia0.92155344
96MP0001485_abnormal_pinna_reflex0.92075290
97MP0005253_abnormal_eye_physiology0.91951076
98MP0002282_abnormal_trachea_morphology0.90786965
99MP0003183_abnormal_peptide_metabolism0.90653825
100MP0004142_abnormal_muscle_tone0.90382742
101MP0003119_abnormal_digestive_system0.89440695
102MP0003861_abnormal_nervous_system0.88115912
103MP0002066_abnormal_motor_capabilities/c0.87285604
104MP0005551_abnormal_eye_electrophysiolog0.86709143
105MP0001529_abnormal_vocalization0.86666830
106MP0002234_abnormal_pharynx_morphology0.84924010
107MP0005174_abnormal_tail_pigmentation0.81600781
108MP0003937_abnormal_limbs/digits/tail_de0.81458549
109MP0002069_abnormal_eating/drinking_beha0.80329643
110MP0002177_abnormal_outer_ear0.80266608
111MP0003329_amyloid_beta_deposits0.79478253
112MP0001286_abnormal_eye_development0.79019182
113MP0005195_abnormal_posterior_eye0.78885132
114MP0002233_abnormal_nose_morphology0.78884498
115MP0010770_preweaning_lethality0.78408041
116MP0002082_postnatal_lethality0.78408041
117MP0004085_abnormal_heartbeat0.78393615
118MP0001177_atelectasis0.77160656
119MP0003567_abnormal_fetal_cardiomyocyte0.77042943
120MP0010769_abnormal_survival0.76997243
121MP0001943_abnormal_respiration0.76392020
122MP0002081_perinatal_lethality0.75251413
123MP0002752_abnormal_somatic_nervous0.71394513
124MP0003172_abnormal_lysosome_physiology0.71329440
125MP0001501_abnormal_sleep_pattern0.70854030
126MP0004043_abnormal_pH_regulation0.70241060
127MP0001346_abnormal_lacrimal_gland0.68427723
128MP0005379_endocrine/exocrine_gland_phen0.68375415
129MP0000026_abnormal_inner_ear0.68363960
130MP0000428_abnormal_craniofacial_morphol0.66993048

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)3.90356693
2Polyphagia (HP:0002591)3.57080975
3Excessive salivation (HP:0003781)3.55591539
4Drooling (HP:0002307)3.55591539
5Sleep apnea (HP:0010535)3.39320168
6High anterior hairline (HP:0009890)3.35580962
7Hyperventilation (HP:0002883)3.31242986
8Exotropia (HP:0000577)3.25893046
9Midline defect of the nose (HP:0004122)3.25574620
10Focal motor seizures (HP:0011153)3.09910570
11Failure to thrive in infancy (HP:0001531)3.09483158
12Prostate neoplasm (HP:0100787)2.95973229
13Coronal craniosynostosis (HP:0004440)2.95656473
14Broad-based gait (HP:0002136)2.95428023
15Thyroid-stimulating hormone excess (HP:0002925)2.88025880
16Papillary thyroid carcinoma (HP:0002895)2.87170158
17Limb dystonia (HP:0002451)2.83529308
18Epileptic encephalopathy (HP:0200134)2.81592227
19Abnormal hair whorl (HP:0010721)2.78240351
20Short 4th metacarpal (HP:0010044)2.74802057
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.74802057
22Focal seizures (HP:0007359)2.73561102
23Progressive cerebellar ataxia (HP:0002073)2.72750470
24Oligodactyly (hands) (HP:0001180)2.64070547
25Gait imbalance (HP:0002141)2.63623012
26Hemiparesis (HP:0001269)2.56566820
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56375549
28Generalized tonic-clonic seizures (HP:0002069)2.54917112
29Dialeptic seizures (HP:0011146)2.50095942
30Abnormal EKG (HP:0003115)2.46642797
31Abnormal eating behavior (HP:0100738)2.45721366
32Esotropia (HP:0000565)2.45299571
33Bradycardia (HP:0001662)2.43376316
34Lissencephaly (HP:0001339)2.40354484
35Abnormality of salivation (HP:0100755)2.37649756
36Volvulus (HP:0002580)2.37523702
37Abnormality of the corticospinal tract (HP:0002492)2.37143123
38Cutaneous finger syndactyly (HP:0010554)2.36492661
39Absent speech (HP:0001344)2.36488987
40Aplasia/Hypoplasia of the clavicles (HP:0006710)2.35466151
41Febrile seizures (HP:0002373)2.34973883
42Intestinal atresia (HP:0011100)2.32198672
43Protruding tongue (HP:0010808)2.29943818
44Medial flaring of the eyebrow (HP:0010747)2.28906839
45Specific learning disability (HP:0001328)2.27851304
46Congenital primary aphakia (HP:0007707)2.26815774
47Abnormality of the renal collecting system (HP:0004742)2.26812499
48Amyotrophic lateral sclerosis (HP:0007354)2.26216418
49Shawl scrotum (HP:0000049)2.25937568
50Poor eye contact (HP:0000817)2.25023070
51Ankle clonus (HP:0011448)2.22052157
52Vitreoretinal degeneration (HP:0000655)2.21847588
53Large earlobe (HP:0009748)2.18730280
54Cortical dysplasia (HP:0002539)2.18477723
55Aplasia/Hypoplasia of the sternum (HP:0006714)2.18392319
56Urinary bladder sphincter dysfunction (HP:0002839)2.15895313
57Duplicated collecting system (HP:0000081)2.14652108
58Hypsarrhythmia (HP:0002521)2.10508718
59Obstructive sleep apnea (HP:0002870)2.10277276
60Abnormality of the labia minora (HP:0012880)2.10214065
61Chromsome breakage (HP:0040012)2.10133331
62Nephrogenic diabetes insipidus (HP:0009806)2.10126608
63* Obsessive-compulsive behavior (HP:0000722)2.10082748
64Medulloblastoma (HP:0002885)2.09941086
65Truncal obesity (HP:0001956)2.09137394
66Pheochromocytoma (HP:0002666)2.06759941
67Partial agenesis of the corpus callosum (HP:0001338)2.06479818
68Macroorchidism (HP:0000053)2.03687772
69Aplasia/Hypoplasia of the lens (HP:0008063)2.03333960
70Truncal ataxia (HP:0002078)2.02563718
71Abnormality of the lower motor neuron (HP:0002366)2.02083014
72Syringomyelia (HP:0003396)2.01701976
73Spinal cord lesions (HP:0100561)2.01701976
74Open mouth (HP:0000194)2.01425321
75Abnormality of the 4th metacarpal (HP:0010012)2.01382553
76Growth hormone deficiency (HP:0000824)2.00608370
77Cutaneous syndactyly (HP:0012725)1.98065849
78Aqueductal stenosis (HP:0002410)1.96969205
79Cupped ear (HP:0000378)1.95639316
80Hip dysplasia (HP:0001385)1.93888655
81Pachygyria (HP:0001302)1.93256593
82Myokymia (HP:0002411)1.93211186
83Narrow forehead (HP:0000341)1.91979421
84Vaginal atresia (HP:0000148)1.91892278
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91205367
86Hypoplasia of the brainstem (HP:0002365)1.91205367
87Morphological abnormality of the middle ear (HP:0008609)1.91079623
88Amblyopia (HP:0000646)1.90055439
89Gaze-evoked nystagmus (HP:0000640)1.89364305
90Impaired vibration sensation in the lower limbs (HP:0002166)1.89311208
91Osteomalacia (HP:0002749)1.89307634
92Genital tract atresia (HP:0001827)1.89282309
93Hepatoblastoma (HP:0002884)1.88986981
94Status epilepticus (HP:0002133)1.88622856
95Split foot (HP:0001839)1.88136007
96Anteriorly placed anus (HP:0001545)1.87685729
97Degeneration of the lateral corticospinal tracts (HP:0002314)1.86591850
98Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86591850
99Primary atrial arrhythmia (HP:0001692)1.86499209
100Urinary urgency (HP:0000012)1.84841438
101Abnormality of the aortic arch (HP:0012303)1.84804678
102Spastic gait (HP:0002064)1.84290023
103Oligodactyly (HP:0012165)1.84112445
104Renal hypoplasia (HP:0000089)1.84056497
105Thickened helices (HP:0000391)1.83653208
106Broad alveolar ridges (HP:0000187)1.83448230
107Inability to walk (HP:0002540)1.83151454
108Ankyloglossia (HP:0010296)1.83102927
109Ventricular tachycardia (HP:0004756)1.81951111
110Small hand (HP:0200055)1.81866428
111Blue irides (HP:0000635)1.80755149
112Genetic anticipation (HP:0003743)1.79654715
113Abnormality of the pubic bones (HP:0003172)1.78848859
114Vertebral arch anomaly (HP:0008438)1.77658536
115Megalencephaly (HP:0001355)1.76242482
116Supraventricular tachycardia (HP:0004755)1.73438939
117Downturned corners of mouth (HP:0002714)1.73394946
118Septo-optic dysplasia (HP:0100842)1.73346943
119Atonic seizures (HP:0010819)1.72943900
120Abnormal social behavior (HP:0012433)1.72133164
121Impaired social interactions (HP:0000735)1.72133164
122Neoplasm of the oral cavity (HP:0100649)1.71540795
123Poor coordination (HP:0002370)1.71301121
124Hypoplasia of the corpus callosum (HP:0002079)1.70296372
125Intellectual disability, severe (HP:0010864)1.69702849
126Neoplasm of the heart (HP:0100544)1.68105569
127Abnormality of the nasal septum (HP:0000419)1.67134550
128Inappropriate behavior (HP:0000719)1.66951299
129Thick eyebrow (HP:0000574)1.66713221
130Optic nerve hypoplasia (HP:0000609)1.66539401
131Tented upper lip vermilion (HP:0010804)1.66509091
132Stereotypic behavior (HP:0000733)1.66315596
133Sacral dimple (HP:0000960)1.66042388
134Supraventricular arrhythmia (HP:0005115)1.65061295
135Atrial fibrillation (HP:0005110)1.64323598
136Gastroesophageal reflux (HP:0002020)1.63792669
137Short clavicles (HP:0000894)1.63746054
138Widely spaced teeth (HP:0000687)1.62826499
139Depression (HP:0000716)1.62683804
140Down-sloping shoulders (HP:0200021)1.61205647
141Epileptiform EEG discharges (HP:0011182)1.61161612
142Large eyes (HP:0001090)1.61101933
143Thin upper lip vermilion (HP:0000219)1.60902160
144Chronic hepatic failure (HP:0100626)1.60300638
145Bronchomalacia (HP:0002780)1.60265733
146Absence seizures (HP:0002121)1.60233054
147EEG with generalized epileptiform discharges (HP:0011198)1.59859631
148Action tremor (HP:0002345)1.59825646
149Generalized hypopigmentation of hair (HP:0011358)1.58710619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK37.45308279
2SIK33.70081570
3MARK13.58351815
4EPHB23.45882788
5NTRK23.02440081
6CASK2.46771222
7FGFR22.39469453
8NTRK32.28495826
9MAP2K72.10845194
10BRD42.07488303
11BCR2.03538239
12KSR11.85897658
13MAP3K41.81408260
14MINK11.75301422
15UHMK11.73738491
16SIK21.71604385
17INSRR1.67121778
18MAPK131.56880347
19ERBB31.53181960
20TRIM281.51689428
21TNIK1.47366421
22MAPK151.32114782
23MAP3K101.24067685
24ERBB21.20365065
25BLK1.16103804
26DYRK21.12064465
27PDGFRA1.09784250
28NTRK11.08730467
29CDK51.05107998
30CAMK1D1.04959340
31CAMKK21.04210778
32CCNB11.02858862
33MAP4K21.01764570
34MKNK20.99236115
35LMTK20.98531112
36MAP3K90.95473294
37FRK0.92716854
38CDC42BPA0.92363520
39CSNK1A1L0.92081091
40CSNK1G20.91453348
41EPHA30.90789514
42CAMKK10.88563745
43PRKCE0.87583131
44MARK20.86190615
45FER0.84635464
46PHKG10.84071189
47PHKG20.84071189
48ZAK0.83915808
49SGK30.83619709
50PAK60.81951738
51PRKCZ0.81716632
52PINK10.80692726
53BMPR1B0.79992412
54SGK4940.76947370
55SGK2230.76947370
56MAP3K60.76717304
57MKNK10.76639133
58PRPF4B0.76044124
59FGFR30.75591271
60EPHA40.75110214
61CAMK2A0.74826513
62CAMK1G0.74689497
63SGK20.72898122
64ADRBK20.71284169
65CDK180.68924024
66CSNK1G30.68536913
67PKN10.67991994
68PRKCG0.67606214
69TYRO30.67022254
70CAMK40.66896787
71DYRK1A0.66844577
72RPS6KA40.66035943
73DYRK30.64250921
74CDK120.61501631
75IRAK20.60807039
76CAMK10.58656279
77STK110.58134342
78ROCK10.57663334
79PIK3CA0.57502486
80CSNK1D0.56514898
81PLK20.56487797
82PRKD30.54730945
83WNK10.54406685
84BMPR20.54369845
85NEK60.52636908
86CDK190.52445418
87AKT30.51042397
88CSNK1A10.50717042
89PRKCH0.50642150
90RPS6KA30.49620459
91PAK30.49260453
92CDK150.48492813
93DMPK0.47941854
94SGK10.47502806
95NUAK10.47322555
96RET0.46912821
97KSR20.46492697
98PNCK0.46261242
99LATS20.45880469
100CDK140.45684241
101MAP2K40.45489066
102CDC70.45078495
103DAPK20.45017169
104HIPK20.44672258
105ATM0.44252516
106FGFR10.43900127
107RPS6KB10.43479318
108DYRK1B0.43391097
109CSNK1G10.43367164
110MAP3K120.42661388
111MAPK100.42172529
112PLK30.41948004
113MELK0.40902635
114GSK3B0.40801342
115MAPK90.40776616
116CDK11A0.40515952
117STK380.39673265
118IRAK10.38977502
119PRKG10.38486911
120CSNK1E0.38480855
121PRKDC0.38386369
122LIMK10.38303252
123PRKAA10.38101538
124GRK50.37698089
125STK390.37395189
126CDK10.36898826
127CDK30.36576381
128ICK0.36416030
129IRAK40.35664159
130FYN0.34309305
131PRKACB0.34073345
132MAPK140.33727675
133CAMK2B0.33533823
134YES10.33461253
135MAPK80.33195204
136MAPK120.33042272

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.23171542
2Taste transduction_Homo sapiens_hsa047422.31395427
3Synaptic vesicle cycle_Homo sapiens_hsa047212.28869386
4Insulin secretion_Homo sapiens_hsa049112.19820456
5Circadian entrainment_Homo sapiens_hsa047132.19376763
6GABAergic synapse_Homo sapiens_hsa047272.11947585
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.06476038
8Glutamatergic synapse_Homo sapiens_hsa047241.97828887
9Morphine addiction_Homo sapiens_hsa050321.95578150
10Dopaminergic synapse_Homo sapiens_hsa047281.88823512
11Axon guidance_Homo sapiens_hsa043601.86526022
12Type II diabetes mellitus_Homo sapiens_hsa049301.78214881
13Cholinergic synapse_Homo sapiens_hsa047251.75517350
14Serotonergic synapse_Homo sapiens_hsa047261.75149966
15Cocaine addiction_Homo sapiens_hsa050301.65441181
16Amphetamine addiction_Homo sapiens_hsa050311.62415236
17Long-term potentiation_Homo sapiens_hsa047201.52455446
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47720274
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46453020
20Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44981069
21Olfactory transduction_Homo sapiens_hsa047401.39709576
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34318302
23Long-term depression_Homo sapiens_hsa047301.30670764
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29090615
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28169988
26Gap junction_Homo sapiens_hsa045401.26678822
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26417146
28Ovarian steroidogenesis_Homo sapiens_hsa049131.25723153
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25426436
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24389711
31Renin secretion_Homo sapiens_hsa049241.22740983
32Oxytocin signaling pathway_Homo sapiens_hsa049211.21006224
33Endometrial cancer_Homo sapiens_hsa052131.17134981
34Salivary secretion_Homo sapiens_hsa049701.13866062
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12299575
36ErbB signaling pathway_Homo sapiens_hsa040121.11736529
37GnRH signaling pathway_Homo sapiens_hsa049121.11239518
38Choline metabolism in cancer_Homo sapiens_hsa052311.09366207
39cAMP signaling pathway_Homo sapiens_hsa040241.08860230
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08535808
41Dilated cardiomyopathy_Homo sapiens_hsa054141.04367650
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03802666
43Vibrio cholerae infection_Homo sapiens_hsa051101.01595123
44Calcium signaling pathway_Homo sapiens_hsa040201.01428472
45Collecting duct acid secretion_Homo sapiens_hsa049660.99130723
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.96840105
47Glioma_Homo sapiens_hsa052140.96162956
48Melanogenesis_Homo sapiens_hsa049160.95044360
49Basal cell carcinoma_Homo sapiens_hsa052170.93089477
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.92392627
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91316166
52Butanoate metabolism_Homo sapiens_hsa006500.90539190
53Hippo signaling pathway_Homo sapiens_hsa043900.90535936
54Notch signaling pathway_Homo sapiens_hsa043300.89842643
55Type I diabetes mellitus_Homo sapiens_hsa049400.89604918
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89443218
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89300277
58Wnt signaling pathway_Homo sapiens_hsa043100.88743599
59Estrogen signaling pathway_Homo sapiens_hsa049150.87012899
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83996153
61MAPK signaling pathway_Homo sapiens_hsa040100.82192877
62Systemic lupus erythematosus_Homo sapiens_hsa053220.82160604
63Gastric acid secretion_Homo sapiens_hsa049710.82015877
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.81511440
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81475897
66Phototransduction_Homo sapiens_hsa047440.81457899
67Hedgehog signaling pathway_Homo sapiens_hsa043400.80728940
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79013527
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75170212
70Oocyte meiosis_Homo sapiens_hsa041140.74046828
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73631482
72Dorso-ventral axis formation_Homo sapiens_hsa043200.73611725
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73515631
74Colorectal cancer_Homo sapiens_hsa052100.73006353
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.71418668
76TGF-beta signaling pathway_Homo sapiens_hsa043500.70791087
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69537384
78mRNA surveillance pathway_Homo sapiens_hsa030150.68606952
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68510652
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67799735
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66817163
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66658194
83Renal cell carcinoma_Homo sapiens_hsa052110.66604486
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64281225
85Ras signaling pathway_Homo sapiens_hsa040140.64089356
86Phagosome_Homo sapiens_hsa041450.63731708
87Steroid biosynthesis_Homo sapiens_hsa001000.62615489
88Thyroid hormone synthesis_Homo sapiens_hsa049180.62318307
89mTOR signaling pathway_Homo sapiens_hsa041500.60375659
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60218477
91FoxO signaling pathway_Homo sapiens_hsa040680.59383330
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58063252
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.57325695
94B cell receptor signaling pathway_Homo sapiens_hsa046620.56820656
95MicroRNAs in cancer_Homo sapiens_hsa052060.55187286
96Melanoma_Homo sapiens_hsa052180.53890653
97Adherens junction_Homo sapiens_hsa045200.53355434
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52891623
99Cardiac muscle contraction_Homo sapiens_hsa042600.52712288
100Rap1 signaling pathway_Homo sapiens_hsa040150.52327445
101Alcoholism_Homo sapiens_hsa050340.51934984
102Lysine degradation_Homo sapiens_hsa003100.50561078
103Autoimmune thyroid disease_Homo sapiens_hsa053200.50493865
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50401253
105N-Glycan biosynthesis_Homo sapiens_hsa005100.50176843
106Non-small cell lung cancer_Homo sapiens_hsa052230.48741188
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48017766
108Prolactin signaling pathway_Homo sapiens_hsa049170.47747486
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46565989
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46528002
111Fanconi anemia pathway_Homo sapiens_hsa034600.45490575
112Ether lipid metabolism_Homo sapiens_hsa005650.45117104
113AMPK signaling pathway_Homo sapiens_hsa041520.44687841
114Inositol phosphate metabolism_Homo sapiens_hsa005620.43443502
115Platelet activation_Homo sapiens_hsa046110.39859891
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39355748
117Pancreatic secretion_Homo sapiens_hsa049720.38877917

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