AFF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.40844107
2pyrimidine nucleobase catabolic process (GO:0006208)4.08636796
3positive regulation of granulocyte differentiation (GO:0030854)3.98494508
4regulation of short-term neuronal synaptic plasticity (GO:0048172)3.93355963
5B cell receptor signaling pathway (GO:0050853)3.75585775
6ionotropic glutamate receptor signaling pathway (GO:0035235)3.67980966
7V(D)J recombination (GO:0033151)3.63479522
8postsynaptic membrane organization (GO:0001941)3.62778094
9mitotic sister chromatid cohesion (GO:0007064)3.61188409
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58110532
11regulation of gamma-delta T cell differentiation (GO:0045586)3.56326768
12negative regulation of histone methylation (GO:0031061)3.56311668
13negative regulation of synaptic transmission, GABAergic (GO:0032229)3.49914255
14nucleosome disassembly (GO:0006337)3.44971206
15protein-DNA complex disassembly (GO:0032986)3.44971206
16neuron cell-cell adhesion (GO:0007158)3.43278290
17presynaptic membrane assembly (GO:0097105)3.42966424
18negative regulation of mast cell activation (GO:0033004)3.42313982
19central nervous system neuron axonogenesis (GO:0021955)3.37353485
20locomotory exploration behavior (GO:0035641)3.33327203
21positive regulation of B cell differentiation (GO:0045579)3.32716616
22synaptic transmission, glutamatergic (GO:0035249)3.32388366
23behavioral response to nicotine (GO:0035095)3.30956420
24axonal fasciculation (GO:0007413)3.30933576
25neuron recognition (GO:0008038)3.25922840
26presynaptic membrane organization (GO:0097090)3.25812292
27glutamate receptor signaling pathway (GO:0007215)3.22115848
28G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21322735
29T cell homeostasis (GO:0043029)3.17849105
30regulation of B cell differentiation (GO:0045577)3.17803599
31regulation of gamma-delta T cell activation (GO:0046643)3.13057518
32nucleobase catabolic process (GO:0046113)3.12969561
33transmission of nerve impulse (GO:0019226)3.11748590
34negative regulation of RNA splicing (GO:0033119)3.09225624
35regulation of action potential (GO:0098900)3.08424858
36alternative mRNA splicing, via spliceosome (GO:0000380)3.05219628
37gamma-aminobutyric acid transport (GO:0015812)3.04288241
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.04142388
39regulation of histone H3-K9 methylation (GO:0051570)3.02888068
40startle response (GO:0001964)3.02669244
41negative regulation of cell killing (GO:0031342)3.00971015
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00971015
43definitive hemopoiesis (GO:0060216)2.97536633
44positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.97293689
45membrane depolarization during action potential (GO:0086010)2.96444504
46synaptic vesicle maturation (GO:0016188)2.95348680
47vocalization behavior (GO:0071625)2.93319721
48neural tube formation (GO:0001841)2.93303047
49gamma-aminobutyric acid signaling pathway (GO:0007214)2.93000605
50neuron-neuron synaptic transmission (GO:0007270)2.91965332
51tachykinin receptor signaling pathway (GO:0007217)2.91432870
52negative T cell selection (GO:0043383)2.89557000
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89486682
54neuronal action potential propagation (GO:0019227)2.89369211
55protein K11-linked deubiquitination (GO:0035871)2.88561634
56mast cell degranulation (GO:0043303)2.88338315
57mast cell activation involved in immune response (GO:0002279)2.88338315
58histone H3-K9 methylation (GO:0051567)2.86258504
59ribosomal small subunit assembly (GO:0000028)2.86017673
60positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.85843786
61T cell selection (GO:0045058)2.85208261
62interkinetic nuclear migration (GO:0022027)2.84121587
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84026038
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83552880
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83552880
66response to interleukin-15 (GO:0070672)2.81712226
67neurotransmitter-gated ion channel clustering (GO:0072578)2.81392789
68embryonic hemopoiesis (GO:0035162)2.80676316
69positive regulation of gene expression, epigenetic (GO:0045815)2.80465292
70auditory behavior (GO:0031223)2.80023663
71negative thymic T cell selection (GO:0045060)2.79597466
72synaptic vesicle exocytosis (GO:0016079)2.79302831
73glucocorticoid receptor signaling pathway (GO:0042921)2.77615705
74exploration behavior (GO:0035640)2.77321443
75histone H3-K4 methylation (GO:0051568)2.76994824
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.76049617
77regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.75183484
78dosage compensation (GO:0007549)2.74426567
79positive regulation of action potential (GO:0045760)2.72735001
80protein localization to synapse (GO:0035418)2.72087497
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71221019
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69719841
83histone H3-K4 trimethylation (GO:0080182)2.68012917
84regulation of synaptic vesicle exocytosis (GO:2000300)2.67437795
85regulation of glutamate receptor signaling pathway (GO:1900449)2.67364209
86establishment of protein localization to Golgi (GO:0072600)2.66674194
87antigen processing and presentation of endogenous antigen (GO:0019883)2.66550847
88positive T cell selection (GO:0043368)2.65805660
89DNA unwinding involved in DNA replication (GO:0006268)2.65258657
90regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.64726103
91antigen processing and presentation via MHC class Ib (GO:0002475)2.63163340
92mRNA splice site selection (GO:0006376)2.62679160
93regulation of granulocyte differentiation (GO:0030852)2.62481435
94regulation of histone H3-K4 methylation (GO:0051569)2.61935187
95regulation of synaptic transmission, glutamatergic (GO:0051966)2.61483222
96negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61067793
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60399893
98negative regulation of histone modification (GO:0031057)2.60032458
99adult walking behavior (GO:0007628)2.59438014
100regulation of synaptic transmission, GABAergic (GO:0032228)2.58992897
101positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.58459643
102megakaryocyte development (GO:0035855)2.58419489
103cerebellar Purkinje cell differentiation (GO:0021702)2.58103025
104cell migration in hindbrain (GO:0021535)2.57753998
105neuronal action potential (GO:0019228)2.57731575
106histone H3-K9 modification (GO:0061647)2.57194961
107positive regulation of developmental pigmentation (GO:0048087)2.55615631
108regulation of DNA endoreduplication (GO:0032875)2.55000843
109histone H4-K16 acetylation (GO:0043984)2.54406963
110detection of light stimulus involved in visual perception (GO:0050908)2.54133876
111detection of light stimulus involved in sensory perception (GO:0050962)2.54133876
112viral transcription (GO:0019083)2.53261097
113mechanosensory behavior (GO:0007638)2.53141385
114synapse assembly (GO:0007416)2.52792451
115regulation of synaptic vesicle transport (GO:1902803)2.52361830
116membrane depolarization (GO:0051899)2.51741637
117regulation of excitatory postsynaptic membrane potential (GO:0060079)2.51051011
118negative regulation of dendrite development (GO:2000171)2.50851888
119cellular response to interleukin-15 (GO:0071350)2.50761775
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.50285594
121cerebral cortex radially oriented cell migration (GO:0021799)2.50170460
122regulation of chromatin binding (GO:0035561)2.49351405
123central nervous system projection neuron axonogenesis (GO:0021952)2.48810510
124pre-miRNA processing (GO:0031054)2.48140080
125spinal cord development (GO:0021510)2.48064228
126cAMP catabolic process (GO:0006198)2.47917309
127antigen receptor-mediated signaling pathway (GO:0050851)2.47518457
128regulation of postsynaptic membrane potential (GO:0060078)2.47270588
129neuron maturation (GO:0042551)2.46992316
130regulation of NFAT protein import into nucleus (GO:0051532)2.46417554
131mast cell activation (GO:0045576)2.46116424
132lymphocyte homeostasis (GO:0002260)2.45440419
133nerve growth factor signaling pathway (GO:0038180)2.45252657
134positive regulation of synaptic transmission, GABAergic (GO:0032230)2.45128472
135establishment of mitochondrion localization (GO:0051654)2.44827025
136regulation of pigment cell differentiation (GO:0050932)2.44698792
137neuronal ion channel clustering (GO:0045161)2.44255719
138proline transport (GO:0015824)2.43789875
139histone H4 acetylation (GO:0043967)2.43338055
140regulation of histone methylation (GO:0031060)2.41914602
141regulation of synapse structural plasticity (GO:0051823)2.41139028
142regulation of neurotransmitter secretion (GO:0046928)2.40544519
143retinal ganglion cell axon guidance (GO:0031290)2.39155195
144histone H4 deacetylation (GO:0070933)2.37892253
145glutamate secretion (GO:0014047)2.37364578
146activated T cell proliferation (GO:0050798)2.37270862
147regulation of neurotransmitter transport (GO:0051588)2.37250883
148histamine secretion (GO:0001821)2.37248484
149histamine transport (GO:0051608)2.36373225
150regulation of neurotransmitter uptake (GO:0051580)2.36324890
151negative regulation of phagocytosis (GO:0050765)2.35920850
152Peyers patch development (GO:0048541)2.35761801
153mucosal-associated lymphoid tissue development (GO:0048537)2.35761801
154synaptic vesicle docking involved in exocytosis (GO:0016081)2.35467069
155translational termination (GO:0006415)2.35449933
156positive regulation of CREB transcription factor activity (GO:0032793)2.35383535
157negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.35201214
158behavioral defense response (GO:0002209)2.32793873
159behavioral fear response (GO:0001662)2.32793873
160negative regulation of neurotransmitter transport (GO:0051589)2.32308355
161natural killer cell differentiation (GO:0001779)2.32086001
162positive regulation of histone H3-K4 methylation (GO:0051571)2.31988334
163regulation of collateral sprouting (GO:0048670)2.31918015
164negative regulation of chromatin modification (GO:1903309)2.31255028
165cyclic nucleotide catabolic process (GO:0009214)2.31204465
166negative regulation of erythrocyte differentiation (GO:0045647)2.30964792
167thymic T cell selection (GO:0045061)2.30639881
168translesion synthesis (GO:0019985)2.29673174
169regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.29253688
170neuromuscular synaptic transmission (GO:0007274)2.29191309
171lymphoid progenitor cell differentiation (GO:0002320)2.26781558
172corticosteroid receptor signaling pathway (GO:0031958)2.25743219
173layer formation in cerebral cortex (GO:0021819)2.25529415
174dendritic spine morphogenesis (GO:0060997)2.25319182
175regulation of B cell receptor signaling pathway (GO:0050855)2.25129406
176B cell homeostasis (GO:0001782)2.24677900
177negative regulation of histone acetylation (GO:0035067)2.24670737
178T cell lineage commitment (GO:0002360)2.24216222
179regulation of protein deacetylation (GO:0090311)2.23497836
180cytoplasmic mRNA processing body assembly (GO:0033962)2.22346093
181nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.22222343
182regulation of erythrocyte differentiation (GO:0045646)2.21993848
183histone H2A acetylation (GO:0043968)2.21405354
184regulation of Rap GTPase activity (GO:0032317)2.21127794
185adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.20958554
186leukocyte homeostasis (GO:0001776)2.20757681
187positive regulation of histone deacetylation (GO:0031065)2.20723797
188histone H3 deacetylation (GO:0070932)2.20613938
189negative regulation of mRNA processing (GO:0050686)2.20293832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.68982111
2EZH2_22144423_ChIP-Seq_EOC_Human5.49314948
3MYC_22102868_ChIP-Seq_BL_Human4.20013619
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.73952449
5GBX2_23144817_ChIP-Seq_PC3_Human3.65452428
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.38452182
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.24628597
8SCL_19346495_ChIP-Seq_HPC-7_Human2.74948726
9VDR_21846776_ChIP-Seq_THP-1_Human2.63707440
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40732990
11CIITA_25753668_ChIP-Seq_RAJI_Human2.39022292
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37440015
13TCF7_22412390_ChIP-Seq_EML_Mouse2.36119339
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28824807
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19396467
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16781436
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13191883
18* RUNX_20019798_ChIP-Seq_JUKART_Human2.11352038
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08971642
20* TP63_19390658_ChIP-ChIP_HaCaT_Human2.06236351
21KDM2B_26808549_Chip-Seq_DND41_Human2.04735298
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96744138
23* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96076683
24* TAF15_26573619_Chip-Seq_HEK293_Human1.95750057
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92647354
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90135112
27ZNF274_21170338_ChIP-Seq_K562_Hela1.88212272
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85910760
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85192575
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.82897474
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82883705
32UTX_26944678_Chip-Seq_JUKART_Human1.82774906
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.81030302
34MAF_26560356_Chip-Seq_TH1_Human1.75854210
35* VDR_24763502_ChIP-Seq_THP-1_Human1.71395656
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71378427
37MYB_26560356_Chip-Seq_TH2_Human1.71083131
38* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70857429
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70562947
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70052781
41VDR_22108803_ChIP-Seq_LS180_Human1.67617819
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.66766347
43P300_19829295_ChIP-Seq_ESCs_Human1.66470002
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.64340192
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62613693
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.62525357
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.60503508
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60162480
49* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60131931
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59506445
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.57540622
52* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55693762
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54392349
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.54286501
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54131626
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54131626
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51612044
58AR_25329375_ChIP-Seq_VCAP_Human1.47244273
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47086723
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46673619
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.46114540
62* STAT3_23295773_ChIP-Seq_U87_Human1.45988557
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45894965
64* TCF4_23295773_ChIP-Seq_U87_Human1.45081252
65* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44615546
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44550390
67* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43762595
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42932912
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42789176
70RNF2_27304074_Chip-Seq_NSC_Mouse1.41171596
71MYB_26560356_Chip-Seq_TH1_Human1.40704377
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39622814
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38384369
74ER_23166858_ChIP-Seq_MCF-7_Human1.36149903
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35946574
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33687194
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.33412048
78* FLI1_27457419_Chip-Seq_LIVER_Mouse1.33013128
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32492295
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32479873
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32143913
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.31812326
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31463239
84* DROSHA_22980978_ChIP-Seq_HELA_Human1.31214340
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28613058
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27607661
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.27600745
88* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26916358
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26818074
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26694518
91* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26394008
92CBP_20019798_ChIP-Seq_JUKART_Human1.26373607
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26373607
94* SPI1_23127762_ChIP-Seq_K562_Human1.26264754
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25872639
96AR_21572438_ChIP-Seq_LNCaP_Human1.24721731
97FUS_26573619_Chip-Seq_HEK293_Human1.24242753
98* RUNX2_22187159_ChIP-Seq_PCA_Human1.21608261
99* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20780497
100TP53_16413492_ChIP-PET_HCT116_Human1.19950846
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19357302
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.19324602
103* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18157774
104BCAT_22108803_ChIP-Seq_LS180_Human1.16379365
105* SOX2_21211035_ChIP-Seq_LN229_Gbm1.15427015
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14974667
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14616289
108* RNF2_27304074_Chip-Seq_ESCs_Mouse1.14536372
109PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12165013
110* EWS_26573619_Chip-Seq_HEK293_Human1.11601693
111* NANOG_18555785_Chip-Seq_ESCs_Mouse1.10612102
112* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10322286
113* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09640772
114* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09640772
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09502675
116FLI1_21867929_ChIP-Seq_TH2_Mouse1.08555374
117AHR_22903824_ChIP-Seq_MCF-7_Human1.08508548
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.07609341
119* AR_19668381_ChIP-Seq_PC3_Human1.07388160
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07159020
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05848214
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05372927
123* IRF8_22096565_ChIP-ChIP_GC-B_Human1.04873941
124MAF_26560356_Chip-Seq_TH2_Human1.04277638
125DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03637504
126* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03084569
127KDM2B_26808549_Chip-Seq_K562_Human1.02032359
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01851974
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01311083
130EZH2_27304074_Chip-Seq_ESCs_Mouse1.01178617
131* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00756177
132* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00650811
133STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00541814
134KDM2B_26808549_Chip-Seq_REH_Human1.00321222
135SALL1_21062744_ChIP-ChIP_HESCs_Human0.98176348
136* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97772431
137TCF4_22108803_ChIP-Seq_LS180_Human0.97433379
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.97152029
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97085327
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.95770228
141FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95649128
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95479710
143JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95278902
144* RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94683474
145IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93684895
146GATA3_27048872_Chip-Seq_THYMUS_Human0.93517456
147SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91019313
148EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90912165
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89612530
150RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88069757
151NOTCH1_21737748_ChIP-Seq_TLL_Human0.87498548
152* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86916590
153* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85536568
154* REST_21632747_ChIP-Seq_MESCs_Mouse0.84978288
155* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82547618
156SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82016381
157SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81314882
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81296470
159* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.79999073
160CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79825754
161NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78872924
162RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.78519283
163MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.78411790
164FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77956384
165IGF1R_20145208_ChIP-Seq_DFB_Human0.77522507
166MTF2_20144788_ChIP-Seq_MESCs_Mouse0.77132428
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75150231
168NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74347270
169RING1B_27294783_Chip-Seq_NPCs_Mouse0.74343611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.56286940
2MP0004859_abnormal_synaptic_plasticity3.21035727
3MP0000569_abnormal_digit_pigmentation2.81205352
4MP0004808_abnormal_hematopoietic_stem2.55065733
5MP0003787_abnormal_imprinting2.53169490
6MP0003763_abnormal_thymus_physiology2.45353866
7MP0009046_muscle_twitch2.30663413
8MP0002822_catalepsy2.27758820
9MP0005174_abnormal_tail_pigmentation2.19138918
10MP0003121_genomic_imprinting2.08325244
11MP0004885_abnormal_endolymph2.07304148
12MP0000703_abnormal_thymus_morphology2.05100485
13MP0010386_abnormal_urinary_bladder2.04588938
14MP0003122_maternal_imprinting1.99160499
15MP0002398_abnormal_bone_marrow1.98075198
16MP0001501_abnormal_sleep_pattern1.97926459
17MP0003635_abnormal_synaptic_transmissio1.95265218
18MP0001800_abnormal_humoral_immune1.85109065
19MP0005551_abnormal_eye_electrophysiolog1.74974392
20MP0005646_abnormal_pituitary_gland1.73784160
21MP0002166_altered_tumor_susceptibility1.72867616
22MP0008877_abnormal_DNA_methylation1.72680362
23MP0002095_abnormal_skin_pigmentation1.70397514
24MP0003183_abnormal_peptide_metabolism1.64010725
25MP0001835_abnormal_antigen_presentation1.62277179
26MP0010094_abnormal_chromosome_stability1.62105779
27MP0004924_abnormal_behavior1.61101691
28MP0005386_behavior/neurological_phenoty1.61101691
29MP0005394_taste/olfaction_phenotype1.59070456
30MP0005499_abnormal_olfactory_system1.59070456
31MP0005423_abnormal_somatic_nervous1.58392089
32MP0004142_abnormal_muscle_tone1.56347339
33MP0005409_darkened_coat_color1.56161670
34MP0002063_abnormal_learning/memory/cond1.54958331
35MP0002733_abnormal_thermal_nociception1.54344996
36MP0000685_abnormal_immune_system1.53855439
37MP0008789_abnormal_olfactory_epithelium1.46472654
38MP0001968_abnormal_touch/_nociception1.42190490
39MP0003880_abnormal_central_pattern1.41824800
40MP0000716_abnormal_immune_system1.41682649
41MP0004742_abnormal_vestibular_system1.38480891
42MP0002722_abnormal_immune_system1.36847653
43MP0000689_abnormal_spleen_morphology1.34512085
44MP0002420_abnormal_adaptive_immunity1.33765305
45MP0008961_abnormal_basal_metabolism1.33699952
46MP0002006_tumorigenesis1.31257372
47MP0002452_abnormal_antigen_presenting1.30859532
48MP0001986_abnormal_taste_sensitivity1.30074071
49MP0001545_abnormal_hematopoietic_system1.29082333
50MP0005397_hematopoietic_system_phenotyp1.29082333
51MP0009278_abnormal_bone_marrow1.29030297
52MP0001819_abnormal_immune_cell1.28443158
53MP0002882_abnormal_neuron_morphology1.27621431
54MP0005645_abnormal_hypothalamus_physiol1.25930902
55MP0005671_abnormal_response_to1.25468028
56MP0002653_abnormal_ependyma_morphology1.25284331
57MP0008569_lethality_at_weaning1.25229832
58MP0002928_abnormal_bile_duct1.24409046
59MP0009745_abnormal_behavioral_response1.24073498
60MP0004811_abnormal_neuron_physiology1.23586644
61MP0002876_abnormal_thyroid_physiology1.22990295
62MP0002938_white_spotting1.22792590
63MP0001440_abnormal_grooming_behavior1.22152279
64MP0002102_abnormal_ear_morphology1.21136812
65MP0001905_abnormal_dopamine_level1.18842939
66MP0001790_abnormal_immune_system1.18013283
67MP0005387_immune_system_phenotype1.18013283
68MP0000015_abnormal_ear_pigmentation1.17145530
69MP0003136_yellow_coat_color1.16862142
70MP0002429_abnormal_blood_cell1.16423821
71MP0005075_abnormal_melanosome_morpholog1.15249664
72MP0004270_analgesia1.14361180
73MP0001502_abnormal_circadian_rhythm1.14114866
74MP0006292_abnormal_olfactory_placode1.13765342
75MP0000465_gastrointestinal_hemorrhage1.13115650
76MP0001984_abnormal_olfaction1.11940809
77MP0002751_abnormal_autonomic_nervous1.11745534
78MP0003077_abnormal_cell_cycle1.09398125
79MP0002723_abnormal_immune_serum1.09257837
80MP0005253_abnormal_eye_physiology1.08669672
81MP0002557_abnormal_social/conspecific_i1.06616531
82MP0002184_abnormal_innervation1.05303418
83MP0003866_abnormal_defecation1.04515748
84MP0002572_abnormal_emotion/affect_behav1.04483397
85MP0002138_abnormal_hepatobiliary_system1.03539256
86MP0006072_abnormal_retinal_apoptosis1.03207896
87MP0005310_abnormal_salivary_gland1.02752851
88MP0001529_abnormal_vocalization1.02377600
89MP0002638_abnormal_pupillary_reflex1.01482759
90MP0006276_abnormal_autonomic_nervous1.01221630
91MP0002752_abnormal_somatic_nervous1.00227848
92MP0005171_absent_coat_pigmentation0.99554290
93MP0002066_abnormal_motor_capabilities/c0.97347937
94MP0001293_anophthalmia0.97221589
95MP0001486_abnormal_startle_reflex0.96715529
96MP0000490_abnormal_crypts_of0.96641289
97MP0000778_abnormal_nervous_system0.96628052
98MP0008057_abnormal_DNA_replication0.96395635
99MP0005503_abnormal_tendon_morphology0.96038863
100MP0002064_seizures0.95652382
101MP0004043_abnormal_pH_regulation0.95253277
102MP0009250_abnormal_appendicular_skeleto0.93814804
103MP0003303_peritoneal_inflammation0.93807397
104MP0003633_abnormal_nervous_system0.93629825
105MP0001963_abnormal_hearing_physiology0.88943623
106MP0008872_abnormal_physiological_respon0.87557918
107MP0000427_abnormal_hair_cycle0.87260383
108MP0001348_abnormal_lacrimal_gland0.86884352
109MP0003861_abnormal_nervous_system0.83595054
110MP0001873_stomach_inflammation0.83437633
111MP0003631_nervous_system_phenotype0.83036844
112MP0002735_abnormal_chemical_nociception0.82906099
113MP0004134_abnormal_chest_morphology0.82723144
114MP0003123_paternal_imprinting0.82140233
115MP0003879_abnormal_hair_cell0.81576432
116MP0010352_gastrointestinal_tract_polyps0.81249523
117MP0005000_abnormal_immune_tolerance0.81017399
118MP0000026_abnormal_inner_ear0.80239879
119MP0002736_abnormal_nociception_after0.80009705
120MP0004147_increased_porphyrin_level0.79989168
121MP0001177_atelectasis0.79872284
122MP0002234_abnormal_pharynx_morphology0.79407196
123MP0003111_abnormal_nucleus_morphology0.79181544
124MP0002272_abnormal_nervous_system0.78974517
125MP0000955_abnormal_spinal_cord0.78595958
126MP0003045_fibrosis0.78587465
127MP0002075_abnormal_coat/hair_pigmentati0.78585756
128MP0000350_abnormal_cell_proliferation0.77684859
129MP0003385_abnormal_body_wall0.77654739
130MP0003935_abnormal_craniofacial_develop0.77624799
131MP0002009_preneoplasia0.76938328
132MP0008007_abnormal_cellular_replicative0.76834165
133MP0001188_hyperpigmentation0.76714750
134MP0000538_abnormal_urinary_bladder0.76605686
135MP0005187_abnormal_penis_morphology0.76414198
136MP0001485_abnormal_pinna_reflex0.76360684
137MP0003300_gastrointestinal_ulcer0.75601449
138MP0002229_neurodegeneration0.74848890
139MP0009703_decreased_birth_body0.74470706
140MP0002019_abnormal_tumor_incidence0.73575943
141MP0002734_abnormal_mechanical_nocicepti0.72394670
142MP0008770_decreased_survivor_rate0.72358825
143MP0002152_abnormal_brain_morphology0.72311057
144MP0004381_abnormal_hair_follicle0.72067486
145MP0003283_abnormal_digestive_organ0.70990717
146MP0002405_respiratory_system_inflammati0.70575135
147MP0002069_abnormal_eating/drinking_beha0.69601213
148MP0002081_perinatal_lethality0.69115778
149MP0001879_abnormal_lymphatic_vessel0.68673168
150MP0000631_abnormal_neuroendocrine_gland0.68547505
151MP0001970_abnormal_pain_threshold0.68207546
152MP0000428_abnormal_craniofacial_morphol0.67932530
153MP0002837_dystrophic_cardiac_calcinosis0.67184706
154MP0003943_abnormal_hepatobiliary_system0.65762255
155MP0002067_abnormal_sensory_capabilities0.65250795
156MP0000372_irregular_coat_pigmentation0.64983630
157MP0005670_abnormal_white_adipose0.64112820
158MP0001664_abnormal_digestion0.63177412

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.49252179
2Progressive cerebellar ataxia (HP:0002073)3.85821892
3Agammaglobulinemia (HP:0004432)3.82132164
4Absent speech (HP:0001344)3.62880021
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.53539509
6Short 4th metacarpal (HP:0010044)3.53539509
7Abnormality of the fingertips (HP:0001211)3.33254025
8Panhypogammaglobulinemia (HP:0003139)3.24465456
9Atonic seizures (HP:0010819)3.23368303
10Pancreatic cysts (HP:0001737)3.13576909
11Acute lymphatic leukemia (HP:0006721)3.08043517
12Epileptic encephalopathy (HP:0200134)3.07350917
13Recurrent bronchitis (HP:0002837)3.06278903
14Nephronophthisis (HP:0000090)3.04130634
15Papilledema (HP:0001085)3.03643159
16Congenital stationary night blindness (HP:0007642)3.01860163
17Gaze-evoked nystagmus (HP:0000640)3.01410749
18Cellulitis (HP:0100658)2.92303643
19Hyperacusis (HP:0010780)2.89622325
20Dialeptic seizures (HP:0011146)2.88430678
21Abnormality of B cell number (HP:0010975)2.88425761
22B lymphocytopenia (HP:0010976)2.88425761
23Papilloma (HP:0012740)2.87426587
24Verrucae (HP:0200043)2.87426587
25Volvulus (HP:0002580)2.78244305
26Protruding tongue (HP:0010808)2.76029150
27Chronic otitis media (HP:0000389)2.72732051
28Trigonocephaly (HP:0000243)2.70951121
29Chronic hepatic failure (HP:0100626)2.69422897
30Thyroiditis (HP:0100646)2.69209681
31Type II lissencephaly (HP:0007260)2.68718114
32Abnormality of the renal medulla (HP:0100957)2.66351242
33Recurrent viral infections (HP:0004429)2.65958119
34Absence seizures (HP:0002121)2.63363083
35Pancreatic fibrosis (HP:0100732)2.60850489
36Long eyelashes (HP:0000527)2.55482522
37Drooling (HP:0002307)2.49763064
38IgM deficiency (HP:0002850)2.48593155
39Molar tooth sign on MRI (HP:0002419)2.47335887
40Abnormality of midbrain morphology (HP:0002418)2.47335887
41Limb dystonia (HP:0002451)2.47121056
42Gait imbalance (HP:0002141)2.45471831
43True hermaphroditism (HP:0010459)2.44502890
44Obsessive-compulsive behavior (HP:0000722)2.44019807
45Hemiparesis (HP:0001269)2.43589732
46Abnormality of the intervertebral disk (HP:0005108)2.41078316
47T lymphocytopenia (HP:0005403)2.40860724
48Abnormality of the parietal bone (HP:0002696)2.35560619
49Abnormality of the 4th metacarpal (HP:0010012)2.34541558
50Excessive salivation (HP:0003781)2.31881299
51Pointed chin (HP:0000307)2.30654779
52Morphological abnormality of the middle ear (HP:0008609)2.27217503
53Increased nuchal translucency (HP:0010880)2.26318224
54Clumsiness (HP:0002312)2.24217060
55Widely spaced teeth (HP:0000687)2.24083737
56Abnormality of the renal cortex (HP:0011035)2.23555672
57Narrow palate (HP:0000189)2.22817326
58Abnormality of binocular vision (HP:0011514)2.20049414
59Diplopia (HP:0000651)2.20049414
60Attenuation of retinal blood vessels (HP:0007843)2.19238711
61Syringomyelia (HP:0003396)2.18528310
62Spinal cord lesions (HP:0100561)2.18528310
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.18160650
64Pachygyria (HP:0001302)2.18139080
65Generalized tonic-clonic seizures (HP:0002069)2.17958807
66Cystic liver disease (HP:0006706)2.17660862
67Polyphagia (HP:0002591)2.17524872
68Renal duplication (HP:0000075)2.15757925
69Chronic sinusitis (HP:0011109)2.15658276
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.15372640
71Intellectual disability, severe (HP:0010864)2.14926646
72Retinal dysplasia (HP:0007973)2.14660307
73Midline defect of the nose (HP:0004122)2.12502638
74Macroorchidism (HP:0000053)2.12481122
75Abnormal eating behavior (HP:0100738)2.11645670
76Abnormality of T cell number (HP:0011839)2.11528455
77Prolonged QT interval (HP:0001657)2.09929916
78Medial flaring of the eyebrow (HP:0010747)2.08506614
79Lissencephaly (HP:0001339)2.07784630
80Amyotrophic lateral sclerosis (HP:0007354)2.04086876
81Sacral dimple (HP:0000960)2.03224516
82Morphological abnormality of the pyramidal tract (HP:0002062)2.01762677
83Hemiplegia (HP:0002301)2.00244292
84Inability to walk (HP:0002540)1.98935491
85Action tremor (HP:0002345)1.98331217
86Asymmetry of the thorax (HP:0001555)1.97380607
87Abnormal number of incisors (HP:0011064)1.97088875
88Meningitis (HP:0001287)1.96424550
89Overriding aorta (HP:0002623)1.94717999
90Cutis marmorata (HP:0000965)1.93093105
91Stomach cancer (HP:0012126)1.93051030
92Abnormal hair whorl (HP:0010721)1.92992119
93Hypoplasia of the thymus (HP:0000778)1.92616980
94Abnormality of the columella (HP:0009929)1.92187143
95Elfin facies (HP:0004428)1.91882128
96Gastrointestinal stroma tumor (HP:0100723)1.89772028
97Abnormality of the corticospinal tract (HP:0002492)1.89521610
98Congenital primary aphakia (HP:0007707)1.89291617
99Broad palm (HP:0001169)1.89158444
100Decreased central vision (HP:0007663)1.89122015
101Ankyloglossia (HP:0010296)1.88607087
102Keratoconus (HP:0000563)1.88503131
103Increased corneal curvature (HP:0100692)1.88503131
104Abolished electroretinogram (ERG) (HP:0000550)1.88290201
105Renovascular hypertension (HP:0100817)1.87782807
106Thick eyebrow (HP:0000574)1.87553282
107Vertebral arch anomaly (HP:0008438)1.87060190
108Myokymia (HP:0002411)1.86404441
109Renal cortical cysts (HP:0000803)1.86063937
110Epileptiform EEG discharges (HP:0011182)1.85789194
111Basal cell carcinoma (HP:0002671)1.85386608
112Aqueductal stenosis (HP:0002410)1.84307279
113Nephrogenic diabetes insipidus (HP:0009806)1.84088893
114Lymphopenia (HP:0001888)1.83297803
115Hip dysplasia (HP:0001385)1.82555192
116Abnormality of oral frenula (HP:0000190)1.82133054
117Genital tract atresia (HP:0001827)1.81817824
118Stereotypic behavior (HP:0000733)1.80850841
119Broad-based gait (HP:0002136)1.79675464
120Short foot (HP:0001773)1.79544588
121EEG with generalized epileptiform discharges (HP:0011198)1.78912572
122Acute myeloid leukemia (HP:0004808)1.77818289
123Focal motor seizures (HP:0011153)1.77362142
124Bony spicule pigmentary retinopathy (HP:0007737)1.76619128
125Agitation (HP:0000713)1.76559742
126Hypsarrhythmia (HP:0002521)1.76472883
127Gastrointestinal inflammation (HP:0004386)1.76451277
128Insomnia (HP:0100785)1.76443503
129Recurrent fungal infections (HP:0002841)1.76379028
130Megalencephaly (HP:0001355)1.76058285
131Abnormality of the ischium (HP:0003174)1.75844749
132Absent frontal sinuses (HP:0002688)1.75276880
133Focal seizures (HP:0007359)1.75230629
134Truncal ataxia (HP:0002078)1.75021570
135Abnormality of cells of the lymphoid lineage (HP:0012140)1.74225389
136Vitreoretinal degeneration (HP:0000655)1.73986429
137Flat cornea (HP:0007720)1.72378801
138IgG deficiency (HP:0004315)1.71614114
139Bowel diverticulosis (HP:0005222)1.70086875
140Febrile seizures (HP:0002373)1.69925767
141Poor eye contact (HP:0000817)1.69246091
142Abnormality of T cells (HP:0002843)1.69121881
143Tented upper lip vermilion (HP:0010804)1.68007935
144Vaginal atresia (HP:0000148)1.67752133
145Inflammation of the large intestine (HP:0002037)1.66488942
146Visual hallucinations (HP:0002367)1.66269130
147Hypoplasia of the maxilla (HP:0000327)1.65940334
148Optic nerve hypoplasia (HP:0000609)1.65850807
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65835480
150Short philtrum (HP:0000322)1.65586086
151Thrombocytosis (HP:0001894)1.65352947
152Hypoplastic ischia (HP:0003175)1.64540814
153Recurrent sinusitis (HP:0011108)1.64437522
154Heterochromia iridis (HP:0001100)1.64028369
155Neoplasm of the adrenal cortex (HP:0100641)1.63230056
156Abnormality of ocular smooth pursuit (HP:0000617)1.63023247
157Abnormal drinking behavior (HP:0030082)1.62832724
158Polydipsia (HP:0001959)1.62832724
159Urinary urgency (HP:0000012)1.61528437
160Prominent nose (HP:0000448)1.60963898
161Genetic anticipation (HP:0003743)1.60913281
162Impaired smooth pursuit (HP:0007772)1.60670594
163Supernumerary ribs (HP:0005815)1.60525215
164Generalized hypopigmentation of hair (HP:0011358)1.60244115
165Colitis (HP:0002583)1.59845829
166Macroglossia (HP:0000158)1.59668470
167Amblyopia (HP:0000646)1.59465948
168Specific learning disability (HP:0001328)1.59414713
169Truncal obesity (HP:0001956)1.59347062
170Annular pancreas (HP:0001734)1.59207163
171Urinary bladder sphincter dysfunction (HP:0002839)1.57911980
172Limited elbow extension (HP:0001377)1.57877788
173Heterotopia (HP:0002282)1.57581752
174Increased density of long bones (HP:0006392)1.57328751
175Colon cancer (HP:0003003)1.56639874
176Medulloblastoma (HP:0002885)1.56282084
177Smooth philtrum (HP:0000319)1.53110401
178Narrow nasal bridge (HP:0000446)1.52954655
179Prolonged bleeding time (HP:0003010)1.52357839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.64855408
2MAP3K104.39634928
3EEF2K4.14011923
4CASK3.40842607
5MAP4K13.22646419
6SIK22.93879592
7FGFR22.24962574
8SIK32.12604197
9CDC71.83913080
10GRK61.81668602
11TAOK31.79521054
12MARK11.76909469
13AKT31.75430587
14NTRK21.71909025
15MAP3K41.68703550
16SYK1.68231233
17WNK31.67573642
18RIPK41.62825770
19FGFR31.54575419
20PINK11.47824030
21CSF1R1.46686234
22CDK191.44419289
23MAPK131.43469621
24MARK21.43189338
25CAMK1G1.42954647
26CDK121.41325391
27MAP2K71.39764253
28KIT1.38255046
29BRD41.34637861
30FES1.32595156
31MAP3K91.32427051
32TNIK1.31231259
33PKN21.30597625
34MINK11.24669837
35MAP3K121.24035157
36BTK1.22182997
37SGK2231.22156734
38SGK4941.22156734
39DAPK21.21211741
40OXSR11.20599599
41ADRBK21.20020486
42NTRK31.19601110
43BMPR21.17221785
44WNK41.16334457
45GRK11.15841087
46TGFBR11.14952011
47LRRK21.13592506
48ALK1.09072571
49BMPR1B1.08655830
50TNK21.08615278
51DYRK21.06662810
52PKN11.02362811
53PAK31.01571503
54KSR11.01333530
55STK391.00947910
56CAMK11.00782365
57MAP3K70.99524217
58PAK60.99422870
59CAMK1D0.99218923
60CAMKK10.96915056
61DAPK10.96017383
62RET0.95810296
63MAP4K20.91842348
64EPHA40.90175701
65INSRR0.89567380
66CAMK40.88328077
67HIPK20.87392288
68MKNK10.86702362
69CDK30.86238994
70HCK0.85612517
71CDK90.85463391
72PIK3CG0.85437518
73SCYL20.83594686
74CDK40.83360237
75ERBB30.80740972
76RPS6KB20.80109333
77TAOK10.79373214
78ATR0.78249681
79ITK0.77921719
80RPS6KA20.76970463
81PRKD30.76501162
82NEK20.75395523
83JAK30.75143504
84PRKCH0.73974751
85DYRK30.73777224
86PRKCZ0.73059887
87ZAP700.72998642
88TRIB30.72267561
89UHMK10.71143561
90CLK10.70993559
91FLT30.70376209
92PRKCG0.69815352
93ADRBK10.67865421
94STK110.66364971
95MAPK40.65421610
96TYRO30.64516133
97MAPK120.64157550
98SGK30.62981881
99MKNK20.61782306
100CAMK2A0.61685086
101TEC0.59819247
102NLK0.59565850
103PRKCE0.59286491
104DYRK1B0.59033511
105RAF10.59006733
106CSNK1A1L0.58506275
107WNK10.57914104
108DMPK0.57696306
109CDK50.57551355
110CSNK1G20.57124262
111RPS6KA60.56169971
112LCK0.56166065
113PNCK0.53512647
114TXK0.53374347
115PHKG20.52797663
116PHKG10.52797663
117SGK10.52615259
118PRKCQ0.52483342
119PIM10.51859534
120MAP2K40.51455852
121RPS6KA40.51178353
122PDGFRA0.50733801
123MAP3K60.50691710
124GRK50.50379190
125RPS6KB10.49945014
126PRKD20.49923572
127STK240.49361350
128LYN0.49318720
129CSNK1D0.48666673
130FYN0.48158287
131SGK20.46569161
132CDK20.45359950
133CAMKK20.44872880
134PDK10.44525006
135CHEK10.44518382
136CHUK0.44503614
137MAPK150.44320414
138PLK20.44185627
139STK380.44102009
140FGFR40.43339454
141NUAK10.43111541
142LATS10.42985709
143PDGFRB0.42972794
144DYRK1A0.41779060
145BCR0.40826067
146MAPK80.40664735
147RPS6KA30.40623658
148MAPK70.40442911
149CCNB10.40171270
150EPHA30.39066929
151BLK0.38930667
152MAP3K130.38361765

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.53200641
2Phototransduction_Homo sapiens_hsa047442.22116110
3B cell receptor signaling pathway_Homo sapiens_hsa046622.14447056
4Olfactory transduction_Homo sapiens_hsa047401.94597111
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76613083
6Insulin secretion_Homo sapiens_hsa049111.74146877
7Asthma_Homo sapiens_hsa053101.66439986
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53977630
9Long-term potentiation_Homo sapiens_hsa047201.53867985
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51211129
11Non-small cell lung cancer_Homo sapiens_hsa052231.48932752
12T cell receptor signaling pathway_Homo sapiens_hsa046601.48171288
13Serotonergic synapse_Homo sapiens_hsa047261.46323795
14Chronic myeloid leukemia_Homo sapiens_hsa052201.45345846
15Dorso-ventral axis formation_Homo sapiens_hsa043201.43089852
16Colorectal cancer_Homo sapiens_hsa052101.41902806
17Glioma_Homo sapiens_hsa052141.39426264
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.38170024
19Dopaminergic synapse_Homo sapiens_hsa047281.34087640
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33765142
21Circadian entrainment_Homo sapiens_hsa047131.33711441
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27049612
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24990357
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24576974
25Morphine addiction_Homo sapiens_hsa050321.24323724
26Alcoholism_Homo sapiens_hsa050341.23152481
27Cholinergic synapse_Homo sapiens_hsa047251.19470054
28DNA replication_Homo sapiens_hsa030301.18899043
29Amphetamine addiction_Homo sapiens_hsa050311.18850130
30Glutamatergic synapse_Homo sapiens_hsa047241.17567425
31Nicotine addiction_Homo sapiens_hsa050331.17161926
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16803353
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16036016
34Acute myeloid leukemia_Homo sapiens_hsa052211.14759736
35Linoleic acid metabolism_Homo sapiens_hsa005911.13957353
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13752876
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13609682
38Non-homologous end-joining_Homo sapiens_hsa034501.12915398
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10552539
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.10045034
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09706297
42mRNA surveillance pathway_Homo sapiens_hsa030151.08981736
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07646224
44Allograft rejection_Homo sapiens_hsa053301.07632080
45Butanoate metabolism_Homo sapiens_hsa006501.07616619
46Endometrial cancer_Homo sapiens_hsa052131.06293595
47Pancreatic cancer_Homo sapiens_hsa052121.03879876
48ErbB signaling pathway_Homo sapiens_hsa040121.02510733
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02092684
50Platelet activation_Homo sapiens_hsa046111.01219921
51Spliceosome_Homo sapiens_hsa030401.00055343
52Hepatitis B_Homo sapiens_hsa051610.99333621
53Cell cycle_Homo sapiens_hsa041100.99198610
54Renin secretion_Homo sapiens_hsa049240.99148363
55Graft-versus-host disease_Homo sapiens_hsa053320.98619077
56Ether lipid metabolism_Homo sapiens_hsa005650.98579321
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97849817
58Oxytocin signaling pathway_Homo sapiens_hsa049210.96747643
59Autoimmune thyroid disease_Homo sapiens_hsa053200.96528122
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92664999
61Chemokine signaling pathway_Homo sapiens_hsa040620.91219599
62MicroRNAs in cancer_Homo sapiens_hsa052060.91008576
63mTOR signaling pathway_Homo sapiens_hsa041500.90852073
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90527365
65VEGF signaling pathway_Homo sapiens_hsa043700.89320963
66Oocyte meiosis_Homo sapiens_hsa041140.89291044
67HTLV-I infection_Homo sapiens_hsa051660.89080625
68Base excision repair_Homo sapiens_hsa034100.88612508
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88366475
70Osteoclast differentiation_Homo sapiens_hsa043800.88244651
71Wnt signaling pathway_Homo sapiens_hsa043100.87870364
72Type I diabetes mellitus_Homo sapiens_hsa049400.87358990
73Gastric acid secretion_Homo sapiens_hsa049710.86273466
74Mismatch repair_Homo sapiens_hsa034300.86203238
75ABC transporters_Homo sapiens_hsa020100.85966174
76Ovarian steroidogenesis_Homo sapiens_hsa049130.85893114
77Salivary secretion_Homo sapiens_hsa049700.85614637
78cAMP signaling pathway_Homo sapiens_hsa040240.85110690
79MAPK signaling pathway_Homo sapiens_hsa040100.84638861
80GnRH signaling pathway_Homo sapiens_hsa049120.83791584
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83510625
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83490940
83Cocaine addiction_Homo sapiens_hsa050300.83071156
84Viral carcinogenesis_Homo sapiens_hsa052030.82624855
85Estrogen signaling pathway_Homo sapiens_hsa049150.82586770
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82295408
87Choline metabolism in cancer_Homo sapiens_hsa052310.82120121
88Prolactin signaling pathway_Homo sapiens_hsa049170.81677623
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80763924
90GABAergic synapse_Homo sapiens_hsa047270.80440838
91Long-term depression_Homo sapiens_hsa047300.79288996
92Notch signaling pathway_Homo sapiens_hsa043300.78994257
93Ribosome_Homo sapiens_hsa030100.78078368
94Melanogenesis_Homo sapiens_hsa049160.77968489
95Calcium signaling pathway_Homo sapiens_hsa040200.77827544
96Herpes simplex infection_Homo sapiens_hsa051680.76635026
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76441725
98Hematopoietic cell lineage_Homo sapiens_hsa046400.76062932
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75223604
100Synaptic vesicle cycle_Homo sapiens_hsa047210.74899463
101Axon guidance_Homo sapiens_hsa043600.74326607
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74054414
103Measles_Homo sapiens_hsa051620.73117464
104Gap junction_Homo sapiens_hsa045400.72856329
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72783562
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72738471
107Type II diabetes mellitus_Homo sapiens_hsa049300.72022323
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.71464453
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.71036041
110Shigellosis_Homo sapiens_hsa051310.70677257
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70324181
112Taste transduction_Homo sapiens_hsa047420.70070735
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.69978956
114Pathways in cancer_Homo sapiens_hsa052000.69447308
115Epstein-Barr virus infection_Homo sapiens_hsa051690.68585380
116Ras signaling pathway_Homo sapiens_hsa040140.68514597
117Basal cell carcinoma_Homo sapiens_hsa052170.68054101
118Thyroid cancer_Homo sapiens_hsa052160.68038195
119FoxO signaling pathway_Homo sapiens_hsa040680.67522720
120Systemic lupus erythematosus_Homo sapiens_hsa053220.66481662
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66479603
122Pancreatic secretion_Homo sapiens_hsa049720.64081914
123Hedgehog signaling pathway_Homo sapiens_hsa043400.63968490
124Inositol phosphate metabolism_Homo sapiens_hsa005620.61592434
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.61407136
126Prostate cancer_Homo sapiens_hsa052150.61374191
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58127749
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54854352
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54712222
130Arachidonic acid metabolism_Homo sapiens_hsa005900.52987165
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47322287
132Lysine degradation_Homo sapiens_hsa003100.47178725
133Circadian rhythm_Homo sapiens_hsa047100.45417313
134Regulation of autophagy_Homo sapiens_hsa041400.44187833
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43085068
136Thyroid hormone synthesis_Homo sapiens_hsa049180.42771222
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42080287
138Dilated cardiomyopathy_Homo sapiens_hsa054140.39472514
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.39100603
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.37176766
141Leishmaniasis_Homo sapiens_hsa051400.36738273
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34547140
143Rap1 signaling pathway_Homo sapiens_hsa040150.33628559

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