AFF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)3.75442098
2hemidesmosome assembly (GO:0031581)3.59197538
3cell adhesion mediated by integrin (GO:0033627)3.57142974
4locomotory exploration behavior (GO:0035641)3.56704003
5regulation of short-term neuronal synaptic plasticity (GO:0048172)3.48672422
6synaptic vesicle maturation (GO:0016188)3.40596679
7regulation of NFAT protein import into nucleus (GO:0051532)3.34328417
8skin morphogenesis (GO:0043589)3.25397831
9establishment of nucleus localization (GO:0040023)3.22307972
10dendrite morphogenesis (GO:0048813)3.20281704
11cytoskeletal anchoring at plasma membrane (GO:0007016)3.19616602
12cytoplasmic mRNA processing body assembly (GO:0033962)3.18160187
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12373543
14regulation of transforming growth factor beta2 production (GO:0032909)3.09321834
15dendritic spine morphogenesis (GO:0060997)2.97051786
16insulin-like growth factor receptor signaling pathway (GO:0048009)2.93872663
17paraxial mesoderm development (GO:0048339)2.91479892
18cell-substrate junction assembly (GO:0007044)2.91245931
19desmosome organization (GO:0002934)2.82197349
20regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.81259099
21axonal fasciculation (GO:0007413)2.76786842
22regulation of clathrin-mediated endocytosis (GO:2000369)2.74766396
23protein targeting to Golgi (GO:0000042)2.72735152
24vesicle transport along microtubule (GO:0047496)2.67683361
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.66156883
26COPII vesicle coating (GO:0048208)2.63949206
27nuclear pore complex assembly (GO:0051292)2.63671755
28vocalization behavior (GO:0071625)2.63452513
29regulation of synaptic vesicle exocytosis (GO:2000300)2.60703040
30positive regulation of p38MAPK cascade (GO:1900745)2.59673139
31stress granule assembly (GO:0034063)2.59477353
32glial cell proliferation (GO:0014009)2.58413591
33establishment of protein localization to Golgi (GO:0072600)2.57329756
34hippo signaling (GO:0035329)2.54901463
35COPI coating of Golgi vesicle (GO:0048205)2.52512539
36Golgi transport vesicle coating (GO:0048200)2.52512539
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52193751
38retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51914855
39regulation of RNA export from nucleus (GO:0046831)2.51480687
40proline transport (GO:0015824)2.50237691
41activation of protein kinase A activity (GO:0034199)2.49849156
42morphogenesis of an epithelial sheet (GO:0002011)2.49195996
43neuron recognition (GO:0008038)2.48708972
44regulation of glutamate receptor signaling pathway (GO:1900449)2.47529965
45exploration behavior (GO:0035640)2.47524844
46dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47483363
47nerve growth factor signaling pathway (GO:0038180)2.47205867
48hypotonic response (GO:0006971)2.46297291
49coronary vasculature morphogenesis (GO:0060977)2.45096678
50semaphorin-plexin signaling pathway (GO:0071526)2.44084027
51regulation of ARF protein signal transduction (GO:0032012)2.43312855
52embryonic camera-type eye morphogenesis (GO:0048596)2.42893827
53plasma membrane repair (GO:0001778)2.42701280
54cerebellar Purkinje cell differentiation (GO:0021702)2.41681030
55glutamate secretion (GO:0014047)2.41464908
56cell-substrate adherens junction assembly (GO:0007045)2.41112660
57focal adhesion assembly (GO:0048041)2.41112660
58embryonic process involved in female pregnancy (GO:0060136)2.41098549
59axon extension (GO:0048675)2.41043651
60inner ear receptor cell development (GO:0060119)2.40727551
61vesicle coating (GO:0006901)2.40430438
62chondrocyte proliferation (GO:0035988)2.40358017
63innervation (GO:0060384)2.39957769
64positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.39664932
65synaptic vesicle docking involved in exocytosis (GO:0016081)2.38742481
66cell migration in hindbrain (GO:0021535)2.38463213
67collagen fibril organization (GO:0030199)2.37839297
68regulation of nucleobase-containing compound transport (GO:0032239)2.37838942
69clathrin coat assembly (GO:0048268)2.37480042
70endodermal cell differentiation (GO:0035987)2.35941002
71regulation of p38MAPK cascade (GO:1900744)2.34815270
72regulation of axon extension involved in axon guidance (GO:0048841)2.34364465
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.34348557
74mating behavior (GO:0007617)2.32775827
75sodium ion export (GO:0071436)2.32662258
76substrate-dependent cell migration (GO:0006929)2.32498444
77retina vasculature morphogenesis in camera-type eye (GO:0061299)2.32424221
78protein localization to endosome (GO:0036010)2.31435993
79neuromuscular process controlling balance (GO:0050885)2.31207324
80organelle transport along microtubule (GO:0072384)2.30141187
81negative regulation of neurotransmitter secretion (GO:0046929)2.29457779
82cell migration involved in sprouting angiogenesis (GO:0002042)2.29044441
83epithelial cell-cell adhesion (GO:0090136)2.29009300
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.28977016
85negative regulation of keratinocyte proliferation (GO:0010839)2.28725676
86central nervous system projection neuron axonogenesis (GO:0021952)2.28164194
87macroautophagy (GO:0016236)2.27666960
88fibroblast migration (GO:0010761)2.27400624
89mesodermal cell differentiation (GO:0048333)2.26671265
90apical protein localization (GO:0045176)2.25963141
91cellular potassium ion homeostasis (GO:0030007)2.25391810
92pericardium development (GO:0060039)2.25333574
93asymmetric protein localization (GO:0008105)2.23644136
94nucleus localization (GO:0051647)2.22668889
95cell communication by electrical coupling (GO:0010644)2.22273695
96regulation of dendritic spine morphogenesis (GO:0061001)2.21756746
97myoblast fusion (GO:0007520)2.19823993
98platelet-derived growth factor receptor signaling pathway (GO:0048008)2.19687631
99eye morphogenesis (GO:0048592)2.19343153
100regulation of axon guidance (GO:1902667)2.18508438
101regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.18335897
102synaptic vesicle exocytosis (GO:0016079)2.17817636
103cerebellar Purkinje cell layer development (GO:0021680)2.16660235
104regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.16580238
105neurotransmitter secretion (GO:0007269)2.16476925
106dendritic spine organization (GO:0097061)2.15970039
107dorsal/ventral axis specification (GO:0009950)2.15640068
108neuron cell-cell adhesion (GO:0007158)2.15297582
109bundle of His cell to Purkinje myocyte communication (GO:0086069)2.15043704
110iron ion import (GO:0097286)2.14069280
111SMAD protein complex assembly (GO:0007183)2.13998321
112peripheral nervous system axon ensheathment (GO:0032292)2.12745190
113myelination in peripheral nervous system (GO:0022011)2.12745190
114nuclear pore organization (GO:0006999)2.12312910
115pre-miRNA processing (GO:0031054)2.11639259
116neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.10890542
117gastrulation with mouth forming second (GO:0001702)2.10615251
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.10363654
119axon extension involved in axon guidance (GO:0048846)2.10363654
120neuron projection extension (GO:1990138)2.10102871
121lipid translocation (GO:0034204)2.10072705
122phospholipid translocation (GO:0045332)2.10072705
123negative regulation of catenin import into nucleus (GO:0035414)2.10012294
124suckling behavior (GO:0001967)2.09252150
125negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.09117896
126positive regulation of glycogen biosynthetic process (GO:0045725)2.08981846
127syncytium formation by plasma membrane fusion (GO:0000768)2.08578247
128regulation of neuron migration (GO:2001222)2.08354082
129planar cell polarity pathway involved in neural tube closure (GO:0090179)2.08034534
130histone H3-K9 demethylation (GO:0033169)2.08033154
131regulation of neuronal synaptic plasticity (GO:0048168)2.07524997
132protein localization to synapse (GO:0035418)2.07309574
133negative regulation of fatty acid transport (GO:2000192)2.06779702
134NLS-bearing protein import into nucleus (GO:0006607)2.06743352
135negative regulation of anoikis (GO:2000811)2.06103341
136basement membrane organization (GO:0071711)2.05805131
137embryonic eye morphogenesis (GO:0048048)2.05460355
138camera-type eye morphogenesis (GO:0048593)2.05336478
139histone lysine demethylation (GO:0070076)2.05330300
140embryonic foregut morphogenesis (GO:0048617)2.04440954
141regulation of long-term neuronal synaptic plasticity (GO:0048169)2.03405914
142synapse organization (GO:0050808)2.03237526
143smooth muscle tissue development (GO:0048745)2.03128657
144histone H3-K36 demethylation (GO:0070544)2.01935375
145ionotropic glutamate receptor signaling pathway (GO:0035235)2.01484698
146maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.01123449
147histone demethylation (GO:0016577)2.00937125
148neuromuscular junction development (GO:0007528)1.99772123
149polarized epithelial cell differentiation (GO:0030859)1.98978281
150regulation of cholesterol homeostasis (GO:2000188)1.98873091
151regulation of synapse structural plasticity (GO:0051823)1.98196831
152sequestering of extracellular ligand from receptor (GO:0035581)1.98196614
153positive regulation of axon extension (GO:0045773)1.97682610
154negative regulation of sodium ion transport (GO:0010766)1.97426806
155embryonic viscerocranium morphogenesis (GO:0048703)1.97419582
156prepulse inhibition (GO:0060134)1.97090106
157negative regulation of vascular permeability (GO:0043116)1.96994471
158adherens junction assembly (GO:0034333)1.96798601
159chondrocyte development (GO:0002063)1.96254215
160protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)1.96185872
161regulation of catenin import into nucleus (GO:0035412)1.96075163
162adherens junction organization (GO:0034332)1.95960554
163negative regulation of translation involved in gene silencing by miRNA (GO:0035278)1.95801513
164negative regulation of translation, ncRNA-mediated (GO:0040033)1.95801513
165regulation of translation, ncRNA-mediated (GO:0045974)1.95801513
166regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)1.95662975
167regulation of synaptic vesicle transport (GO:1902803)1.95303499
168regulation of Rac protein signal transduction (GO:0035020)1.95283298
169heart morphogenesis (GO:0003007)1.95070424
170peptidyl-lysine dimethylation (GO:0018027)1.94128221
171regulation of cardioblast differentiation (GO:0051890)1.93811265
172embryonic retina morphogenesis in camera-type eye (GO:0060059)1.93789154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.15537668
2EZH2_22144423_ChIP-Seq_EOC_Human2.61483096
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47347556
4GBX2_23144817_ChIP-Seq_PC3_Human2.23995685
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.21306284
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15531056
7ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10745078
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00734259
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92579859
10DROSHA_22980978_ChIP-Seq_HELA_Human1.84988978
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83354237
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82317946
13* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78971998
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.71367283
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71282449
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69648731
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69243600
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69243600
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.65846433
20SOX9_24532713_ChIP-Seq_HFSC_Mouse1.64379858
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64313411
22AHR_22903824_ChIP-Seq_MCF-7_Human1.63823248
23* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63711227
24* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63621825
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63235694
26TP53_16413492_ChIP-PET_HCT116_Human1.62018430
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61959471
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60246209
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.55799145
30AR_21572438_ChIP-Seq_LNCaP_Human1.55234740
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.52099967
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52019284
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51868674
34CJUN_26792858_Chip-Seq_BT549_Human1.51633097
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51058635
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49988026
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49414042
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49288286
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48622877
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48552493
41SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48552493
42* RARB_27405468_Chip-Seq_BRAIN_Mouse1.47756242
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47327502
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45647558
45BRD4_25478319_ChIP-Seq_HGPS_Human1.45517385
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45129909
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.45003796
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.43527340
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42926474
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42424583
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42047869
52SMAD4_21799915_ChIP-Seq_A2780_Human1.41405166
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.39520180
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37845207
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36856614
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36813229
57SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36367902
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36147760
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.35990925
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35296000
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33667721
62ZNF274_21170338_ChIP-Seq_K562_Hela1.33509194
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33234965
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32017459
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.30374485
66STAT3_23295773_ChIP-Seq_U87_Human1.29927596
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.29291372
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26644852
69* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25038104
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24142077
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.23422292
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22972084
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22533250
74AR_19668381_ChIP-Seq_PC3_Human1.22097686
75KDM2B_26808549_Chip-Seq_K562_Human1.21418198
76* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20668357
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.20639866
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.20624515
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20188717
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19948923
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.19556915
82* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19429404
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18757852
84PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.18565008
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.18196266
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17794394
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16201371
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16073989
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15463585
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.15452331
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.14776185
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13507287
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13498783
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13119913
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13094424
96* RING1B_27294783_Chip-Seq_NPCs_Mouse1.13040752
97REST_21632747_ChIP-Seq_MESCs_Mouse1.12383595
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12048368
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12030708
100RXR_22108803_ChIP-Seq_LS180_Human1.11357402
101* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11178654
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.10638952
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10371479
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10113192
105TP53_18474530_ChIP-ChIP_U2OS_Human1.08811845
106* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08576975
107TBX20_22080862_ChIP-Seq_HEART_Mouse1.08057881
108TBX20_22328084_ChIP-Seq_HEART_Mouse1.08057881
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07404783
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.07246884
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07216254
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06064180
113BCAT_22108803_ChIP-Seq_LS180_Human1.05600670
114TCF4_23295773_ChIP-Seq_U87_Human1.05075745
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03633361
116SMAD4_21741376_ChIP-Seq_HESCs_Human1.03309420
117RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02932650
118TP63_23658742_ChIP-Seq_EP156T_Human1.02366500
119POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02205041
120TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02056768
121CLOCK_20551151_ChIP-Seq_293T_Human1.01501370
122TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01398401
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01025970
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01025970
125SMAD3_21741376_ChIP-Seq_HESCs_Human1.00511764
126CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00122197
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.98851019
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98560773
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98373603
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97449533
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97448908
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96062286
133* UBF1/2_26484160_Chip-Seq_HMECs_Human0.90996577
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89892527
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89741829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.44886011
2MP0000569_abnormal_digit_pigmentation3.35014869
3MP0009780_abnormal_chondrocyte_physiolo3.13169062
4MP0010234_abnormal_vibrissa_follicle2.92462902
5MP0005409_darkened_coat_color2.69274562
6MP0003705_abnormal_hypodermis_morpholog2.38282941
7MP0005623_abnormal_meninges_morphology2.37005720
8MP0004270_analgesia2.31666456
9MP0003283_abnormal_digestive_organ2.21677605
10MP0001299_abnormal_eye_distance/2.18995103
11MP0000537_abnormal_urethra_morphology2.09130194
12MP0005257_abnormal_intraocular_pressure2.08234005
13MP0003635_abnormal_synaptic_transmissio2.05025607
14MP0003941_abnormal_skin_development2.00606652
15MP0005076_abnormal_cell_differentiation1.85599639
16MP0003950_abnormal_plasma_membrane1.85014098
17MP0004885_abnormal_endolymph1.84714899
18MP0008438_abnormal_cutaneous_collagen1.80414908
19MP0003045_fibrosis1.80343634
20MP0010368_abnormal_lymphatic_system1.78707044
21MP0005187_abnormal_penis_morphology1.69806671
22MP0000778_abnormal_nervous_system1.66316591
23MP0003300_gastrointestinal_ulcer1.66080678
24MP0003122_maternal_imprinting1.65797016
25MP0003787_abnormal_imprinting1.65442086
26MP0002063_abnormal_learning/memory/cond1.65023739
27MP0001958_emphysema1.64847408
28MP0005248_abnormal_Harderian_gland1.57190060
29MP0002909_abnormal_adrenal_gland1.54107140
30MP0000013_abnormal_adipose_tissue1.51656291
31MP0002877_abnormal_melanocyte_morpholog1.50880169
32MP0000579_abnormal_nail_morphology1.49079732
33MP0005023_abnormal_wound_healing1.47464984
34MP0010352_gastrointestinal_tract_polyps1.47224699
35MP0002896_abnormal_bone_mineralization1.44774303
36MP0008961_abnormal_basal_metabolism1.41692035
37MP0004272_abnormal_basement_membrane1.40732712
38MP0002060_abnormal_skin_morphology1.40635163
39MP0004858_abnormal_nervous_system1.39770063
40MP0000767_abnormal_smooth_muscle1.37842309
41MP0005275_abnormal_skin_tensile1.37630904
42MP0005503_abnormal_tendon_morphology1.35253934
43MP0003279_aneurysm1.35042213
44MP0002234_abnormal_pharynx_morphology1.33772888
45MP0001486_abnormal_startle_reflex1.31746199
46MP0000003_abnormal_adipose_tissue1.30769618
47MP0009745_abnormal_behavioral_response1.30470450
48MP0001879_abnormal_lymphatic_vessel1.30357638
49MP0003091_abnormal_cell_migration1.28482060
50MP0000762_abnormal_tongue_morphology1.28140171
51MP0003453_abnormal_keratinocyte_physiol1.26137856
52MP0002734_abnormal_mechanical_nocicepti1.22992418
53MP0001177_atelectasis1.21498707
54MP0009046_muscle_twitch1.21405701
55MP0000733_abnormal_muscle_development1.20561336
56MP0003121_genomic_imprinting1.20174514
57MP0003890_abnormal_embryonic-extraembry1.20068163
58MP0010678_abnormal_skin_adnexa1.19986280
59MP0001915_intracranial_hemorrhage1.19838548
60MP0002064_seizures1.18567024
61MP0002572_abnormal_emotion/affect_behav1.17083150
62MP0002184_abnormal_innervation1.15336984
63MP0000534_abnormal_ureter_morphology1.14823351
64MP0005423_abnormal_somatic_nervous1.14691154
65MP0002009_preneoplasia1.14421348
66MP0004264_abnormal_extraembryonic_tissu1.12156512
67MP0004811_abnormal_neuron_physiology1.09328358
68MP0006072_abnormal_retinal_apoptosis1.07453953
69MP0000428_abnormal_craniofacial_morphol1.07264850
70MP0004185_abnormal_adipocyte_glucose1.06821706
71MP0000383_abnormal_hair_follicle1.05704490
72MP0000432_abnormal_head_morphology1.03404905
73MP0003868_abnormal_feces_composition1.03296467
74MP0003119_abnormal_digestive_system1.03201908
75MP0003935_abnormal_craniofacial_develop1.02787579
76MP0000955_abnormal_spinal_cord1.01854332
77MP0003385_abnormal_body_wall1.01556063
78MP0002108_abnormal_muscle_morphology1.00806639
79MP0006138_congestive_heart_failure1.00681792
80MP0003115_abnormal_respiratory_system1.00578928
81MP0003566_abnormal_cell_adhesion0.98992011
82MP0009384_cardiac_valve_regurgitation0.98410093
83MP0002092_abnormal_eye_morphology0.96763394
84MP0002152_abnormal_brain_morphology0.96563552
85MP0000516_abnormal_urinary_system0.96501410
86MP0005367_renal/urinary_system_phenotyp0.96501410
87MP0001849_ear_inflammation0.96445365
88MP0002925_abnormal_cardiovascular_devel0.95489489
89MP0003755_abnormal_palate_morphology0.94549038
90MP0002882_abnormal_neuron_morphology0.94383790
91MP0003937_abnormal_limbs/digits/tail_de0.92800097
92MP0008057_abnormal_DNA_replication0.92773082
93MP0003828_pulmonary_edema0.92331997
94MP0006054_spinal_hemorrhage0.91356832
95* MP0002557_abnormal_social/conspecific_i0.91306703
96MP0001440_abnormal_grooming_behavior0.91134371
97MP0004233_abnormal_muscle_weight0.90911889
98MP0005375_adipose_tissue_phenotype0.90643769
99MP0003861_abnormal_nervous_system0.89978114
100MP0002090_abnormal_vision0.89437070
101MP0002796_impaired_skin_barrier0.89213042
102MP0005508_abnormal_skeleton_morphology0.88539852
103MP0009053_abnormal_anal_canal0.88448666
104MP0001348_abnormal_lacrimal_gland0.88422604
105MP0001501_abnormal_sleep_pattern0.88210999
106MP0010630_abnormal_cardiac_muscle0.87876422
107MP0009250_abnormal_appendicular_skeleto0.87367605
108MP0003880_abnormal_central_pattern0.86965302
109MP0004134_abnormal_chest_morphology0.86203392
110MP0003632_abnormal_nervous_system0.86091302
111MP0004087_abnormal_muscle_fiber0.85297406
112MP0000631_abnormal_neuroendocrine_gland0.84654287
113MP0009703_decreased_birth_body0.84589390
114MP0003123_paternal_imprinting0.83400626
115MP0002233_abnormal_nose_morphology0.83164019
116MP0000627_abnormal_mammary_gland0.82732525
117MP0005645_abnormal_hypothalamus_physiol0.81772387
118MP0002272_abnormal_nervous_system0.81754030
119MP0005386_behavior/neurological_phenoty0.81605380
120MP0004924_abnormal_behavior0.81605380
121MP0002168_other_aberrant_phenotype0.80632984
122MP0002697_abnormal_eye_size0.80004968
123MP0003329_amyloid_beta_deposits0.79899633
124MP0001502_abnormal_circadian_rhythm0.79637477
125MP0000462_abnormal_digestive_system0.79546645
126MP0000751_myopathy0.79163406
127MP0004782_abnormal_surfactant_physiolog0.79102101
128MP0003942_abnormal_urinary_system0.78996125
129MP0003634_abnormal_glial_cell0.78782865
130MP0002086_abnormal_extraembryonic_tissu0.78344470
131MP0002067_abnormal_sensory_capabilities0.77287187
132MP0004084_abnormal_cardiac_muscle0.77265273
133MP0005551_abnormal_eye_electrophysiolog0.75925130
134MP0002084_abnormal_developmental_patter0.75726362
135MP0008004_abnormal_stomach_pH0.75210993
136MP0004130_abnormal_muscle_cell0.74828449
137MP0005621_abnormal_cell_physiology0.74630341
138MP0001614_abnormal_blood_vessel0.74501716
139MP0005197_abnormal_uvea_morphology0.73546749
140MP0008569_lethality_at_weaning0.73255824
141MP0000759_abnormal_skeletal_muscle0.72888476
142MP0002116_abnormal_craniofacial_bone0.72320429
143MP0002733_abnormal_thermal_nociception0.72252123
144MP0000377_abnormal_hair_follicle0.71452095
145MP0002128_abnormal_blood_circulation0.70702210
146MP0002098_abnormal_vibrissa_morphology0.69441931
147MP0001216_abnormal_epidermal_layer0.68995046
148MP0005666_abnormal_adipose_tissue0.68802647

Predicted human phenotypes

RankGene SetZ-score
1Macroorchidism (HP:0000053)3.07224659
2Shallow orbits (HP:0000586)2.78353686
3Termporal pattern (HP:0011008)2.60371305
4Insidious onset (HP:0003587)2.60371305
5Subacute progressive viral hepatitis (HP:0006572)2.59576250
6Cerebral aneurysm (HP:0004944)2.49009369
7Action tremor (HP:0002345)2.46354322
8Focal seizures (HP:0007359)2.35849448
9Wormian bones (HP:0002645)2.27895272
10Aqueductal stenosis (HP:0002410)2.23076948
11Abnormality of the distal phalanx of the thumb (HP:0009617)2.19246020
12Excessive salivation (HP:0003781)2.16048098
13Drooling (HP:0002307)2.16048098
14Cubitus valgus (HP:0002967)2.15554297
15Abnormality of the nasal septum (HP:0000419)2.15375173
16Genetic anticipation (HP:0003743)2.15341868
17Neonatal short-limb short stature (HP:0008921)2.11969129
18Neurofibrillary tangles (HP:0002185)2.11721220
19Buphthalmos (HP:0000557)2.09916277
20Right ventricular cardiomyopathy (HP:0011663)2.08136200
21Broad face (HP:0000283)2.03309947
22Hypoplastic ischia (HP:0003175)2.02223398
23Osteolytic defects of the hand bones (HP:0009699)2.02073394
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.02073394
25Advanced eruption of teeth (HP:0006288)1.99898256
26Bowel diverticulosis (HP:0005222)1.98154635
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97993922
28Mitral valve prolapse (HP:0001634)1.97863709
29Progressive cerebellar ataxia (HP:0002073)1.97438646
30Flat acetabular roof (HP:0003180)1.95804941
31Heterotopia (HP:0002282)1.94948550
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94923981
33Short 4th metacarpal (HP:0010044)1.94923981
34Ankyloglossia (HP:0010296)1.94769314
35Abnormality of the astrocytes (HP:0100707)1.94557386
36Astrocytoma (HP:0009592)1.94557386
37Bronchomalacia (HP:0002780)1.92946280
38Narrow palate (HP:0000189)1.91475163
39Cervical subluxation (HP:0003308)1.90382821
40Absent frontal sinuses (HP:0002688)1.90325791
41Syringomyelia (HP:0003396)1.89926124
42Spinal cord lesions (HP:0100561)1.89926124
43Relative macrocephaly (HP:0004482)1.89699030
44Turricephaly (HP:0000262)1.89415927
45Natal tooth (HP:0000695)1.88508301
46Neonatal hypoglycemia (HP:0001998)1.87173344
47Overgrowth (HP:0001548)1.86898427
48Obstructive sleep apnea (HP:0002870)1.84644696
49Visual hallucinations (HP:0002367)1.83892538
50Abnormality of the ischium (HP:0003174)1.83147138
51Hyperacusis (HP:0010780)1.82620894
52Bladder diverticulum (HP:0000015)1.82420046
53Ulnar bowing (HP:0003031)1.81476352
54Enlarged penis (HP:0000040)1.80823226
55Pulmonic stenosis (HP:0001642)1.80588373
56Elfin facies (HP:0004428)1.80127112
57Broad metatarsal (HP:0001783)1.79676559
58Renovascular hypertension (HP:0100817)1.79571766
59Focal motor seizures (HP:0011153)1.79491793
60Mitral stenosis (HP:0001718)1.79224716
61Joint laxity (HP:0001388)1.78592594
62Hepatoblastoma (HP:0002884)1.78450395
63Aortic aneurysm (HP:0004942)1.78372509
64Abnormality of the corticospinal tract (HP:0002492)1.78295494
65Papillary thyroid carcinoma (HP:0002895)1.77263463
66Fragile skin (HP:0001030)1.77248589
67Wide anterior fontanel (HP:0000260)1.77235974
68Mitral regurgitation (HP:0001653)1.76977826
69Abnormality of the lower motor neuron (HP:0002366)1.76933076
70Long eyelashes (HP:0000527)1.76828788
71Hyperextensible skin (HP:0000974)1.76274296
72Obsessive-compulsive behavior (HP:0000722)1.76157564
73Urinary bladder sphincter dysfunction (HP:0002839)1.75771196
74Germ cell neoplasia (HP:0100728)1.75484356
75Arterial tortuosity (HP:0005116)1.74713065
76Spondylolisthesis (HP:0003302)1.72593137
77Truncal ataxia (HP:0002078)1.72549691
78Soft skin (HP:0000977)1.72211114
79Premature rupture of membranes (HP:0001788)1.70734953
80Asymmetry of the thorax (HP:0001555)1.70149374
81Persistence of primary teeth (HP:0006335)1.70031494
82Pointed chin (HP:0000307)1.69644072
83Lower limb amyotrophy (HP:0007210)1.69346522
84Neoplasm of the heart (HP:0100544)1.69315699
85Atrophic scars (HP:0001075)1.68775224
86Hypoplasia of the iris (HP:0007676)1.68457118
87Deep philtrum (HP:0002002)1.68330445
88Dilatation of the ascending aorta (HP:0005111)1.68229415
89Aneurysm (HP:0002617)1.68134388
90Aplasia involving bones of the upper limbs (HP:0009823)1.68060105
91Aplasia of the phalanges of the hand (HP:0009802)1.68060105
92Aplasia involving bones of the extremities (HP:0009825)1.68060105
93Exotropia (HP:0000577)1.67684841
94Abnormality of oral frenula (HP:0000190)1.67466303
95Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.67420536
96Hammertoe (HP:0001765)1.67049065
97Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66840990
98Short nail (HP:0001799)1.66284291
99Dysmetric saccades (HP:0000641)1.66206485
100Resting tremor (HP:0002322)1.65832660
101Abnormality of the phalanges of the hallux (HP:0010057)1.65261408
102Follicular hyperkeratosis (HP:0007502)1.65194907
103Vascular tortuosity (HP:0004948)1.64860430
104Laryngomalacia (HP:0001601)1.64813407
105Impaired vibration sensation in the lower limbs (HP:0002166)1.64667978
106Spinal rigidity (HP:0003306)1.64435036
107Papilledema (HP:0001085)1.63907724
108Agitation (HP:0000713)1.63811054
109Tibial bowing (HP:0002982)1.62677000
110Lymphangioma (HP:0100764)1.62493597
111Dislocated radial head (HP:0003083)1.62472698
112Transitional cell carcinoma of the bladder (HP:0006740)1.61988752
113Vertebral arch anomaly (HP:0008438)1.61814360
114Protrusio acetabuli (HP:0003179)1.61757359
115Ankle contracture (HP:0006466)1.60824051
116Scapular winging (HP:0003691)1.60589229
117Arnold-Chiari malformation (HP:0002308)1.60333759
118Cerebral inclusion bodies (HP:0100314)1.60139399
119Megalencephaly (HP:0001355)1.59719134
120Urinary urgency (HP:0000012)1.59643446
121Disproportionate tall stature (HP:0001519)1.59067173
122Dysdiadochokinesis (HP:0002075)1.58651147
123Broad thumb (HP:0011304)1.58369081
124Large earlobe (HP:0009748)1.57939942
125Open mouth (HP:0000194)1.57812578
126Upper limb amyotrophy (HP:0009129)1.56721213
127Distal upper limb amyotrophy (HP:0007149)1.56721213
128Curly hair (HP:0002212)1.56405374
129Sparse lateral eyebrow (HP:0005338)1.56073781
130Overriding aorta (HP:0002623)1.56045960
131Milia (HP:0001056)1.55698770
132Mild short stature (HP:0003502)1.55682220
133Abnormality of the 4th metacarpal (HP:0010012)1.55598689
134Absence seizures (HP:0002121)1.55557640
135Volvulus (HP:0002580)1.55511470
136Insomnia (HP:0100785)1.55377599
137Renal duplication (HP:0000075)1.55199336
138Abnormality of dentin (HP:0010299)1.54339985
139Intention tremor (HP:0002080)1.53303890
140Hypoplastic labia majora (HP:0000059)1.53213054
141Bladder neoplasm (HP:0009725)1.53199361
142Bladder carcinoma (HP:0002862)1.53199361
143Coronal craniosynostosis (HP:0004440)1.52665518
144Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.52630352
145Genu recurvatum (HP:0002816)1.51864692
146Aortic dissection (HP:0002647)1.51854074
147Hypoplastic nipples (HP:0002557)1.51574017
148Lip pit (HP:0100267)1.51226902
149Abnormality of the fingertips (HP:0001211)1.51114200
150Striae distensae (HP:0001065)1.50240520
151Exostoses (HP:0100777)1.50071494
152Dental malocclusion (HP:0000689)1.49997087
153Broad ribs (HP:0000885)1.49712271
154Abnormality of the epiphyses of the hand (HP:0005924)1.49500384
155Atonic seizures (HP:0010819)1.49436505
156Thoracolumbar scoliosis (HP:0002944)1.49121954
157Abnormal ossification of hand bones (HP:0005921)1.48286315
158Abnormality of the radial head (HP:0003995)1.48021207
159Flat cornea (HP:0007720)1.47524463
160Limited hip movement (HP:0008800)1.46794153
161Precocious puberty (HP:0000826)1.46399298
162Hyporeflexia of lower limbs (HP:0002600)1.46167144
163Truncal obesity (HP:0001956)1.43736107
164Coarse hair (HP:0002208)1.43626255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS12.71667412
2NTRK32.64985405
3MARK12.50900035
4MAP3K92.42860695
5CAMK1G2.24391018
6RIPK12.06113307
7PDGFRA2.05132347
8FGFR22.04402622
9FRK2.02093413
10MAP3K21.92576495
11MAP3K41.91191618
12CAMK1D1.86923934
13CDK121.85686196
14DDR21.78339383
15PRKD31.71015219
16PAK61.62750496
17FER1.52902372
18SCYL21.51556312
19KSR11.49977854
20PNCK1.49976420
21NTRK11.48448246
22EPHA41.43823880
23PAK31.40176454
24TYRO31.38565909
25CASK1.38373938
26RET1.36839305
27LATS21.36401327
28TRPM71.34548618
29NTRK21.33418400
30PDGFRB1.31798957
31SIK11.30332848
32KSR21.30023055
33ICK1.22722659
34PTK61.22008689
35TRIB31.20095488
36STK38L1.19935120
37PKN21.14880455
38PRKCH1.12752206
39FGFR41.11947730
40CAMKK11.11207800
41NEK91.11115377
42DMPK1.10906757
43WNK11.08193640
44MINK11.07735241
45SGK31.07317024
46ALK1.06626313
47TTN1.06410877
48ERBB31.02338848
49FGFR11.02274387
50EPHA21.00599416
51MTOR1.00207559
52PTK21.00190661
53BRD40.98891941
54FGFR30.94585031
55PRPF4B0.94558836
56MAP3K60.93166946
57DAPK20.91073789
58SGK20.90694772
59INSRR0.90087429
60CDK50.89452216
61STK110.89231735
62LMTK20.87948672
63MAP2K40.87423524
64MST1R0.86133987
65CDC42BPA0.85227944
66BMX0.84713115
67STK380.82980300
68SGK2230.82653395
69SGK4940.82653395
70SIK20.80118153
71MET0.79653362
72STK390.78026260
73EPHA30.78022863
74CSNK1A1L0.76744124
75SGK10.75663359
76AKT30.74454913
77TGFBR20.74018087
78EPHB20.73984547
79CDK60.72128853
80PAK20.71472979
81NEK60.71258451
82CSNK1G20.70897698
83MOS0.70222828
84ERBB20.70129914
85PIK3CA0.68548705
86MARK20.68230014
87CSNK1D0.66136385
88PHKG10.66042498
89PHKG20.66042498
90MAP3K70.64888025
91BCR0.64066848
92PLK20.62873851
93HIPK20.61981340
94JAK10.61174183
95MAPK100.60164621
96ROCK10.57265246
97ERBB40.56874190
98UHMK10.56786408
99MAP3K100.55805409
100STK240.55458324
101EPHB10.54338180
102YES10.54281948
103RPS6KA30.53580723
104PRKAA20.52971748
105FLT30.52631431
106WNK30.52555813
107STK30.52047614
108DYRK1B0.51531425
109GSK3A0.51312538
110PRKCE0.49708179
111PRKAA10.48711409
112FYN0.46512740
113PRKD20.46326074
114PRKD10.45588697
115INSR0.44467446
116RPS6KA20.43852444
117CHUK0.43832027
118MAPK80.42661729
119MAPK70.42620414
120MELK0.42357185
121CAMK40.41932338
122EEF2K0.41694323
123TAOK10.41460684
124MYLK0.41437410
125PDPK10.40654212
126MAP2K10.40541232
127NLK0.40315288
128DYRK1A0.36069166
129ROCK20.35703162
130MAPK10.33836072
131RPS6KB10.33484435
132MAP3K130.33219185

Predicted pathways (KEGG)

RankGene SetZ-score
1Type II diabetes mellitus_Homo sapiens_hsa049301.66508262
2Nitrogen metabolism_Homo sapiens_hsa009101.63334879
3Long-term potentiation_Homo sapiens_hsa047201.62967531
4Circadian entrainment_Homo sapiens_hsa047131.54936561
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50699920
6GABAergic synapse_Homo sapiens_hsa047271.50107983
7Nicotine addiction_Homo sapiens_hsa050331.45658455
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45509685
9Circadian rhythm_Homo sapiens_hsa047101.42820889
10Insulin secretion_Homo sapiens_hsa049111.42178391
11Amphetamine addiction_Homo sapiens_hsa050311.41521847
12Dorso-ventral axis formation_Homo sapiens_hsa043201.41050310
13Olfactory transduction_Homo sapiens_hsa047401.39677388
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.39594622
15Glutamatergic synapse_Homo sapiens_hsa047241.38336998
16Dopaminergic synapse_Homo sapiens_hsa047281.38119636
17Glioma_Homo sapiens_hsa052141.35464496
18Thyroid cancer_Homo sapiens_hsa052161.35308888
19Axon guidance_Homo sapiens_hsa043601.34122080
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31799101
21Estrogen signaling pathway_Homo sapiens_hsa049151.31443473
22Renin secretion_Homo sapiens_hsa049241.30804207
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30312688
24Morphine addiction_Homo sapiens_hsa050321.29853123
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29667035
26Cholinergic synapse_Homo sapiens_hsa047251.29218234
27Synaptic vesicle cycle_Homo sapiens_hsa047211.28528937
28Gastric acid secretion_Homo sapiens_hsa049711.27162839
29Small cell lung cancer_Homo sapiens_hsa052221.27075669
30Salivary secretion_Homo sapiens_hsa049701.26926921
31mTOR signaling pathway_Homo sapiens_hsa041501.26320375
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24291599
33GnRH signaling pathway_Homo sapiens_hsa049121.22827344
34Cocaine addiction_Homo sapiens_hsa050301.22494311
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22161110
36Endometrial cancer_Homo sapiens_hsa052131.20931889
37Adherens junction_Homo sapiens_hsa045201.20402343
38ErbB signaling pathway_Homo sapiens_hsa040121.19124452
39Focal adhesion_Homo sapiens_hsa045101.17789940
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16281149
41Oxytocin signaling pathway_Homo sapiens_hsa049211.16048371
42Notch signaling pathway_Homo sapiens_hsa043301.14472752
43Melanogenesis_Homo sapiens_hsa049161.13455491
44Proteoglycans in cancer_Homo sapiens_hsa052051.12875069
45Dilated cardiomyopathy_Homo sapiens_hsa054141.12816794
46Gap junction_Homo sapiens_hsa045401.12660407
47ECM-receptor interaction_Homo sapiens_hsa045121.11358579
48Long-term depression_Homo sapiens_hsa047301.10744029
49Hippo signaling pathway_Homo sapiens_hsa043901.10717759
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10686105
51Renal cell carcinoma_Homo sapiens_hsa052111.09800043
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08256918
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06433430
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02413436
55Prion diseases_Homo sapiens_hsa050201.02166266
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99213313
57cAMP signaling pathway_Homo sapiens_hsa040240.99124106
58Tight junction_Homo sapiens_hsa045300.96957686
59Thyroid hormone synthesis_Homo sapiens_hsa049180.94579262
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91635998
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90866702
62Taste transduction_Homo sapiens_hsa047420.89591385
63Chronic myeloid leukemia_Homo sapiens_hsa052200.89500959
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.89434169
65Wnt signaling pathway_Homo sapiens_hsa043100.89242089
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88442084
67Basal cell carcinoma_Homo sapiens_hsa052170.88038717
68Colorectal cancer_Homo sapiens_hsa052100.87951290
69MicroRNAs in cancer_Homo sapiens_hsa052060.87390622
70Fatty acid biosynthesis_Homo sapiens_hsa000610.87375442
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.87029285
72Amoebiasis_Homo sapiens_hsa051460.85947506
73Pathways in cancer_Homo sapiens_hsa052000.85548662
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84905725
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84891821
76Hedgehog signaling pathway_Homo sapiens_hsa043400.84112667
77MAPK signaling pathway_Homo sapiens_hsa040100.82978756
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82590749
79Serotonergic synapse_Homo sapiens_hsa047260.81955064
80Rap1 signaling pathway_Homo sapiens_hsa040150.81806024
81Choline metabolism in cancer_Homo sapiens_hsa052310.81686253
82Insulin resistance_Homo sapiens_hsa049310.80429622
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80267193
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80059391
85Glucagon signaling pathway_Homo sapiens_hsa049220.78974857
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.78528998
87Prostate cancer_Homo sapiens_hsa052150.78065750
88Acute myeloid leukemia_Homo sapiens_hsa052210.77279964
89Phototransduction_Homo sapiens_hsa047440.76658252
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76416627
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76230456
92Insulin signaling pathway_Homo sapiens_hsa049100.76112902
93Non-small cell lung cancer_Homo sapiens_hsa052230.76098546
94Calcium signaling pathway_Homo sapiens_hsa040200.72373304
95AMPK signaling pathway_Homo sapiens_hsa041520.70697698
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.70321842
97Melanoma_Homo sapiens_hsa052180.70208412
98Pancreatic secretion_Homo sapiens_hsa049720.70111907
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.69460523
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69177835
101Sphingolipid metabolism_Homo sapiens_hsa006000.69156172
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68436181
103Protein digestion and absorption_Homo sapiens_hsa049740.68409534
104TGF-beta signaling pathway_Homo sapiens_hsa043500.67986278
105FoxO signaling pathway_Homo sapiens_hsa040680.67906714
106Pancreatic cancer_Homo sapiens_hsa052120.67826939
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.67646542
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67308047
109Ras signaling pathway_Homo sapiens_hsa040140.67151341
110Lysine degradation_Homo sapiens_hsa003100.65534728
111Inositol phosphate metabolism_Homo sapiens_hsa005620.65221347
112VEGF signaling pathway_Homo sapiens_hsa043700.64883912
113Prolactin signaling pathway_Homo sapiens_hsa049170.64836475
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.61984464
115Bile secretion_Homo sapiens_hsa049760.61046958
116Bladder cancer_Homo sapiens_hsa052190.60746640
117Endocytosis_Homo sapiens_hsa041440.60601506
118Hepatitis C_Homo sapiens_hsa051600.58280378
119TNF signaling pathway_Homo sapiens_hsa046680.56801083
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55501216
121Vibrio cholerae infection_Homo sapiens_hsa051100.54875699
122Ovarian steroidogenesis_Homo sapiens_hsa049130.54089704

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