AFG3L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.48482127
2lysine metabolic process (GO:0006553)6.12142836
3lysine catabolic process (GO:0006554)6.12142836
4nuclear pore organization (GO:0006999)5.63480001
5DNA unwinding involved in DNA replication (GO:0006268)5.42516072
6tricarboxylic acid cycle (GO:0006099)5.12213506
72-oxoglutarate metabolic process (GO:0006103)5.06310323
8mitotic chromosome condensation (GO:0007076)4.94620490
9carnitine shuttle (GO:0006853)4.88184875
10regulation of translational fidelity (GO:0006450)4.77136436
11fatty acid transmembrane transport (GO:1902001)4.72650482
12aspartate family amino acid catabolic process (GO:0009068)4.69950057
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.66555545
14L-phenylalanine metabolic process (GO:0006558)4.66555545
15pore complex assembly (GO:0046931)4.64255372
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.51319314
17L-phenylalanine catabolic process (GO:0006559)4.51319314
18glyoxylate metabolic process (GO:0046487)4.50692441
19cysteine metabolic process (GO:0006534)4.49969370
20amino-acid betaine metabolic process (GO:0006577)4.41735094
21kynurenine metabolic process (GO:0070189)4.38125526
22proline biosynthetic process (GO:0006561)4.35246123
23tricarboxylic acid metabolic process (GO:0072350)4.34824222
24fatty acid beta-oxidation (GO:0006635)4.34471132
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.32079247
26cellular ketone body metabolic process (GO:0046950)4.30443884
27alpha-linolenic acid metabolic process (GO:0036109)4.29967684
28sulfur amino acid catabolic process (GO:0000098)4.19150814
29NADH metabolic process (GO:0006734)4.18593745
30acetyl-CoA metabolic process (GO:0006084)4.16903363
31carnitine metabolic process (GO:0009437)4.15198328
32oxaloacetate metabolic process (GO:0006107)4.10596611
33dicarboxylic acid biosynthetic process (GO:0043650)4.09786492
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.07475191
35formation of translation preinitiation complex (GO:0001731)4.01636553
36regulation of fatty acid oxidation (GO:0046320)3.98230601
37fatty acid oxidation (GO:0019395)3.97502787
38protein complex localization (GO:0031503)3.93764328
39aromatic amino acid family catabolic process (GO:0009074)3.89369735
40cellular protein complex localization (GO:0034629)3.88720990
41regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.88089324
42lipid oxidation (GO:0034440)3.87731708
43regulation of fatty acid beta-oxidation (GO:0031998)3.87565201
44valine metabolic process (GO:0006573)3.86231794
45regulation of triglyceride catabolic process (GO:0010896)3.85453164
46short-chain fatty acid metabolic process (GO:0046459)3.82949207
47fatty acid catabolic process (GO:0009062)3.81258224
48positive regulation of fatty acid beta-oxidation (GO:0032000)3.80444951
49urea metabolic process (GO:0019627)3.80433316
50urea cycle (GO:0000050)3.80433316
51carnitine transmembrane transport (GO:1902603)3.79438602
52serine family amino acid catabolic process (GO:0009071)3.78387947
53regulation of cholesterol homeostasis (GO:2000188)3.78155863
54amino-acid betaine transport (GO:0015838)3.77281544
55carnitine transport (GO:0015879)3.77281544
56regulation of RNA export from nucleus (GO:0046831)3.75821576
57DNA strand elongation involved in DNA replication (GO:0006271)3.74144073
58fatty acid homeostasis (GO:0055089)3.74142258
59ribosome assembly (GO:0042255)3.73671334
60COPI coating of Golgi vesicle (GO:0048205)3.72025681
61Golgi transport vesicle coating (GO:0048200)3.72025681
62ketone body metabolic process (GO:1902224)3.71681581
63negative regulation of fatty acid biosynthetic process (GO:0045717)3.68098456
64homocysteine metabolic process (GO:0050667)3.67885558
65succinate metabolic process (GO:0006105)3.65619979
66DNA strand elongation (GO:0022616)3.65591079
67glycine metabolic process (GO:0006544)3.62409949
68ethanol oxidation (GO:0006069)3.62349650
694-hydroxyproline metabolic process (GO:0019471)3.59690457
70glutamate metabolic process (GO:0006536)3.54901379
71monocarboxylic acid catabolic process (GO:0072329)3.54094407
72cellular modified amino acid catabolic process (GO:0042219)3.51277349
73positive regulation of fatty acid oxidation (GO:0046321)3.49430715
74alpha-amino acid catabolic process (GO:1901606)3.48146597
75indole-containing compound catabolic process (GO:0042436)3.47439845
76indolalkylamine catabolic process (GO:0046218)3.47439845
77tryptophan catabolic process (GO:0006569)3.47439845
78nitrogen cycle metabolic process (GO:0071941)3.45664516
79bile acid biosynthetic process (GO:0006699)3.45078547
80regulation of acyl-CoA biosynthetic process (GO:0050812)3.43507597
81regulation of sequestering of triglyceride (GO:0010889)3.43365135
82negative regulation of fibrinolysis (GO:0051918)3.41745330
83mitotic sister chromatid cohesion (GO:0007064)3.40362439
84actin-myosin filament sliding (GO:0033275)3.39862707
85muscle filament sliding (GO:0030049)3.39862707
86regulation of cofactor metabolic process (GO:0051193)3.39357880
87regulation of coenzyme metabolic process (GO:0051196)3.39357880
88IMP metabolic process (GO:0046040)3.39301309
89mitotic sister chromatid segregation (GO:0000070)3.39013144
90DNA replication initiation (GO:0006270)3.38974053
91serine family amino acid metabolic process (GO:0009069)3.38285916
92protein localization to chromosome, centromeric region (GO:0071459)3.37347768
93regulation of nucleobase-containing compound transport (GO:0032239)3.36808375
94triglyceride homeostasis (GO:0070328)3.36365810
95acylglycerol homeostasis (GO:0055090)3.36365810
96cellular amino acid catabolic process (GO:0009063)3.34976716
97negative regulation of fatty acid metabolic process (GO:0045922)3.34763676
98negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.29606118
99biotin metabolic process (GO:0006768)3.29471131
100DNA duplex unwinding (GO:0032508)3.25900244
101protein carboxylation (GO:0018214)3.25664992
102peptidyl-glutamic acid carboxylation (GO:0017187)3.25664992
103phospholipid homeostasis (GO:0055091)3.25133102
104negative regulation of sterol transport (GO:0032372)3.23888139
105negative regulation of cholesterol transport (GO:0032375)3.23888139
106branched-chain amino acid catabolic process (GO:0009083)3.23745456
107establishment of integrated proviral latency (GO:0075713)3.23708584
108sister chromatid segregation (GO:0000819)3.23057427
109sarcomere organization (GO:0045214)3.22648318
110regulation of protein activation cascade (GO:2000257)3.21863392
111regulation of translational termination (GO:0006449)3.21713411
112high-density lipoprotein particle remodeling (GO:0034375)3.21101280
113RNA stabilization (GO:0043489)3.20837738
114mRNA stabilization (GO:0048255)3.20837738
115tryptophan metabolic process (GO:0006568)3.20460081
116branched-chain amino acid metabolic process (GO:0009081)3.19983306
117plasma lipoprotein particle clearance (GO:0034381)3.19580975
118quaternary ammonium group transport (GO:0015697)3.18768992
119positive regulation of lipid catabolic process (GO:0050996)3.18515370
120carboxylic acid catabolic process (GO:0046395)3.17749519
121organic acid catabolic process (GO:0016054)3.17749519
122complement activation, alternative pathway (GO:0006957)3.14012339
123nucleobase-containing small molecule interconversion (GO:0015949)3.13257695
124IMP biosynthetic process (GO:0006188)3.12825146
125mitotic nuclear envelope disassembly (GO:0007077)3.10999007
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10950740
127bile acid metabolic process (GO:0008206)3.09975153
128serine family amino acid biosynthetic process (GO:0009070)3.09261777
129folic acid-containing compound biosynthetic process (GO:0009396)3.09115900
130gluconeogenesis (GO:0006094)3.08827388
131regulation of fatty acid biosynthetic process (GO:0042304)3.08641806
132dicarboxylic acid metabolic process (GO:0043648)3.06165936
133DNA geometric change (GO:0032392)3.06104178
134positive regulation of triglyceride metabolic process (GO:0090208)3.05269459
135regulation of complement activation (GO:0030449)3.03354601
136flavonoid metabolic process (GO:0009812)2.99831938
137telomere maintenance via semi-conservative replication (GO:0032201)2.99608188
138chromosome condensation (GO:0030261)2.99013768
139membrane disassembly (GO:0030397)2.98132642
140nuclear envelope disassembly (GO:0051081)2.98132642
141mitotic metaphase plate congression (GO:0007080)2.97515369
142peptidyl-arginine omega-N-methylation (GO:0035247)2.95986529
143pentose-phosphate shunt (GO:0006098)2.91714481
144protein localization to kinetochore (GO:0034501)2.89883840
145spliceosomal tri-snRNP complex assembly (GO:0000244)2.89183257
146proline metabolic process (GO:0006560)2.86817393
147regulation of mitotic spindle organization (GO:0060236)2.86714554
148protein export from nucleus (GO:0006611)2.86188262
149DNA topological change (GO:0006265)2.83890176
150ribosome biogenesis (GO:0042254)2.81337284
151regulation of sister chromatid cohesion (GO:0007063)2.80212636
152glycolytic process (GO:0006096)2.79923719
153peptidyl-lysine dimethylation (GO:0018027)2.78320669
154DNA conformation change (GO:0071103)2.76942638
155actin-mediated cell contraction (GO:0070252)2.76622695
156tRNA aminoacylation for protein translation (GO:0006418)2.76321564
157retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.76006529
158positive regulation of chromosome segregation (GO:0051984)2.75719940
159creatine metabolic process (GO:0006600)2.72738371
160negative regulation of potassium ion transmembrane transport (GO:1901380)2.71843370
161negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71384985
162focal adhesion assembly (GO:0048041)2.70605397
163cell-substrate adherens junction assembly (GO:0007045)2.70605397
164hexose biosynthetic process (GO:0019319)2.69821770
165NADPH regeneration (GO:0006740)2.69661212
166non-recombinational repair (GO:0000726)2.68724930
167double-strand break repair via nonhomologous end joining (GO:0006303)2.68724930
168cellular hyperosmotic response (GO:0071474)2.68360057
169DNA synthesis involved in DNA repair (GO:0000731)2.67019517
170monosaccharide biosynthetic process (GO:0046364)2.63940970
171regulation of translational elongation (GO:0006448)2.63242436
172amino acid activation (GO:0043038)2.62319887
173tRNA aminoacylation (GO:0043039)2.62319887
174protoporphyrinogen IX metabolic process (GO:0046501)2.62182971
175folic acid metabolic process (GO:0046655)2.62083596
176histone arginine methylation (GO:0034969)2.60416068
177sarcoplasmic reticulum calcium ion transport (GO:0070296)2.59981117
178nuclear envelope organization (GO:0006998)2.59386827
179bundle of His cell to Purkinje myocyte communication (GO:0086069)2.58623570
180histone H2B ubiquitination (GO:0033523)2.58043859
181adherens junction assembly (GO:0034333)2.56035961
182telomere maintenance via recombination (GO:0000722)2.54055587
183skeletal muscle contraction (GO:0003009)2.53390517
184mitochondrial DNA metabolic process (GO:0032042)2.51750504
185regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.49277709
186DNA packaging (GO:0006323)2.48088905
1873-UTR-mediated mRNA stabilization (GO:0070935)2.46081266
188maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.44960258
189peptidyl-arginine methylation (GO:0018216)2.44711538
190peptidyl-arginine N-methylation (GO:0035246)2.44711538
191mitotic recombination (GO:0006312)2.42894346

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.66989674
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.25928114
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.26242985
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.94528707
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.01065964
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.43816262
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.03416000
8ZNF263_19887448_ChIP-Seq_K562_Human2.96818825
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.91411606
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55554795
11* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.55175664
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40568661
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39268981
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.37401770
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35739774
16CLOCK_20551151_ChIP-Seq_293T_Human2.35719380
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34745045
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.34513120
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29311534
20GATA1_22025678_ChIP-Seq_K562_Human2.24100954
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22078322
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19759278
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15587298
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14032753
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.08191839
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97079010
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92287385
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.87113102
29* E2F1_21310950_ChIP-Seq_MCF-7_Human1.82054713
30CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.80163868
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79255027
32XRN2_22483619_ChIP-Seq_HELA_Human1.78010898
33MYC_22102868_ChIP-Seq_BL_Human1.75277737
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73812043
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.73352979
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71011185
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70348625
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70231531
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66189336
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61389798
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.60553981
42DCP1A_22483619_ChIP-Seq_HELA_Human1.58698699
43* ATF3_27146783_Chip-Seq_COLON_Human1.56931966
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55437587
45LXR_22292898_ChIP-Seq_THP-1_Human1.53593796
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51035605
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49785776
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45556078
49CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45096021
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45028423
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44008859
52RACK7_27058665_Chip-Seq_MCF-7_Human1.39675066
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38580797
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38564971
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38259640
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37214211
57CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36918524
58* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33860131
59TBX20_22328084_ChIP-Seq_HEART_Mouse1.33082165
60TBX20_22080862_ChIP-Seq_HEART_Mouse1.33082165
61* TFEB_21752829_ChIP-Seq_HELA_Human1.31236550
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31230341
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27355234
64CHD1_26751641_Chip-Seq_LNCaP_Human1.27061397
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24418646
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23795488
67* FOXA2_19822575_ChIP-Seq_HepG2_Human1.23444551
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22705164
69E2F7_22180533_ChIP-Seq_HELA_Human1.19901988
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.19899009
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19737846
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19599752
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18312077
74TTF2_22483619_ChIP-Seq_HELA_Human1.18161560
75KDM2B_26808549_Chip-Seq_DND41_Human1.17946000
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16220482
77AR_21909140_ChIP-Seq_LNCAP_Human1.16177637
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16074865
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15973873
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.14723485
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13874749
82KDM5A_27292631_Chip-Seq_BREAST_Human1.13687474
83TCF7_22412390_ChIP-Seq_EML_Mouse1.13027846
84GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12874115
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.11103851
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10019637
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09788066
88HNF4A_19822575_ChIP-Seq_HepG2_Human1.09338013
89* P68_20966046_ChIP-Seq_HELA_Human1.09041930
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08978916
91GATA6_25053715_ChIP-Seq_YYC3_Human1.08879219
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08315541
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07239427
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06892235
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06548293
96GATA1_19941826_ChIP-Seq_K562_Human1.06179040
97* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05037776
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04662659
99* GABP_19822575_ChIP-Seq_HepG2_Human1.04461106
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04234210
101TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04221723
102CREB1_26743006_Chip-Seq_LNCaP_Human1.03267905
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03210255
104VDR_21846776_ChIP-Seq_THP-1_Human1.02555440
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02034579
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01437431
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99811995
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.98818401
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97789807
110* GATA1_19941827_ChIP-Seq_MEL_Mouse0.96368364
111ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95827177
112* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95739417
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95619501
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94607621
115EGR1_19374776_ChIP-ChIP_THP-1_Human0.94566714
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.93795326
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93069123
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93052786
119BCOR_27268052_Chip-Seq_Bcells_Human0.92426819
120* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91638402
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91583240
122* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91404416
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91096925
124EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90940707
125CIITA_25753668_ChIP-Seq_RAJI_Human0.90922330
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90907506
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90754632
128* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90227371
129CTCF_21964334_Chip-Seq_Bcells_Human0.89175486
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88524181
131* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87997666
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.87852362
133NCOR1_26117541_ChIP-Seq_K562_Human0.87100986
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85864179
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85464812
136MYC_18555785_ChIP-Seq_MESCs_Mouse0.85086215
137* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84711725
138CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83061064
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82711930
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82503077
141FOXM1_23109430_ChIP-Seq_U2OS_Human0.81642750
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80775929
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.80315628
144GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80198932
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80031751
146BCL6_27268052_Chip-Seq_Bcells_Human0.79342236
147GATA2_19941826_ChIP-Seq_K562_Human0.79120002
148* PHF8_20622854_ChIP-Seq_HELA_Human0.79016279
149RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78978126
150TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.77634296
151RUNX1_27514584_Chip-Seq_MCF-7_Human0.76878479
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76625097
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76566223
154E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76439364
155EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.75508668
156RXRA_24833708_ChIP-Seq_LIVER_Mouse0.74789873
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74747557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.18014079
2MP0002139_abnormal_hepatobiliary_system5.14063936
3MP0005085_abnormal_gallbladder_physiolo4.18349047
4MP0005365_abnormal_bile_salt3.97924395
5MP0003806_abnormal_nucleotide_metabolis3.53561152
6MP0002837_dystrophic_cardiac_calcinosis3.47761794
7MP0003646_muscle_fatigue3.07798300
8MP0003693_abnormal_embryo_hatching3.05932259
9MP0010094_abnormal_chromosome_stability2.95317464
10MP0004957_abnormal_blastocyst_morpholog2.94943352
11MP0003111_abnormal_nucleus_morphology2.92063804
12MP0008875_abnormal_xenobiotic_pharmacok2.89280870
13MP0008057_abnormal_DNA_replication2.86979951
14MP0003705_abnormal_hypodermis_morpholog2.78925415
15MP0009840_abnormal_foam_cell2.73570647
16MP0004084_abnormal_cardiac_muscle2.69879204
17MP0010329_abnormal_lipoprotein_level2.54605508
18MP0003252_abnormal_bile_duct2.52995504
19MP0000751_myopathy2.45218087
20MP0004130_abnormal_muscle_cell2.36304211
21MP0003077_abnormal_cell_cycle2.29345280
22MP0005332_abnormal_amino_acid2.21796123
23MP0005330_cardiomyopathy2.20166948
24MP0004215_abnormal_myocardial_fiber2.11440957
25MP0005083_abnormal_biliary_tract2.06108027
26MP0001661_extended_life_span2.00017167
27MP0004036_abnormal_muscle_relaxation1.97267624
28MP0003941_abnormal_skin_development1.95988161
29MP0005666_abnormal_adipose_tissue1.90828765
30MP0001666_abnormal_nutrient_absorption1.86792551
31* MP0004087_abnormal_muscle_fiber1.79805622
32MP0005670_abnormal_white_adipose1.78366739
33MP0008932_abnormal_embryonic_tissue1.77178341
34MP0000609_abnormal_liver_physiology1.77028613
35* MP0006036_abnormal_mitochondrial_physio1.75642442
36* MP0002269_muscular_atrophy1.74810651
37MP0005319_abnormal_enzyme/_coenzyme1.72182093
38MP0002118_abnormal_lipid_homeostasis1.69742245
39MP0000749_muscle_degeneration1.69119132
40MP0003191_abnormal_cellular_cholesterol1.67988507
41MP0000350_abnormal_cell_proliferation1.65759790
42MP0003195_calcinosis1.59654598
43MP0008775_abnormal_heart_ventricle1.56111151
44MP0004185_abnormal_adipocyte_glucose1.54120109
45MP0002009_preneoplasia1.53916392
46MP0010630_abnormal_cardiac_muscle1.53729571
47MP0005380_embryogenesis_phenotype1.53089573
48MP0001672_abnormal_embryogenesis/_devel1.53089573
49MP0003221_abnormal_cardiomyocyte_apopto1.52302507
50MP0000537_abnormal_urethra_morphology1.51839366
51MP0003656_abnormal_erythrocyte_physiolo1.50618075
52MP0004233_abnormal_muscle_weight1.45924449
53MP0008007_abnormal_cellular_replicative1.44773589
54MP0010307_abnormal_tumor_latency1.43218061
55MP0009697_abnormal_copulation1.42614292
56MP0002080_prenatal_lethality1.41593614
57MP0010352_gastrointestinal_tract_polyps1.38245071
58MP0002796_impaired_skin_barrier1.37667356
59MP0001697_abnormal_embryo_size1.35882552
60MP0005385_cardiovascular_system_phenoty1.35473945
61MP0001544_abnormal_cardiovascular_syste1.35473945
62MP0005058_abnormal_lysosome_morphology1.35210435
63MP0008058_abnormal_DNA_repair1.33857495
64MP0002972_abnormal_cardiac_muscle1.32899488
65MP0004145_abnormal_muscle_electrophysio1.32213253
66MP0005584_abnormal_enzyme/coenzyme_acti1.31313099
67* MP0000747_muscle_weakness1.31280841
68MP0000750_abnormal_muscle_regeneration1.30912901
69MP0010234_abnormal_vibrissa_follicle1.27791020
70MP0002971_abnormal_brown_adipose1.27336166
71MP0009643_abnormal_urine_homeostasis1.26854133
72MP0005501_abnormal_skin_physiology1.26319820
73MP0008961_abnormal_basal_metabolism1.25479983
74MP0002396_abnormal_hematopoietic_system1.24991611
75MP0005620_abnormal_muscle_contractility1.22927584
76MP0005375_adipose_tissue_phenotype1.20581866
77MP0002086_abnormal_extraembryonic_tissu1.19776026
78MP0000733_abnormal_muscle_development1.17685148
79MP0002106_abnormal_muscle_physiology1.17138668
80MP0006138_congestive_heart_failure1.16398677
81MP0003453_abnormal_keratinocyte_physiol1.14669018
82MP0005266_abnormal_metabolism1.14411020
83MP0006035_abnormal_mitochondrial_morpho1.13301613
84MP0005257_abnormal_intraocular_pressure1.11908823
85MP0000313_abnormal_cell_death1.06610125
86MP0002078_abnormal_glucose_homeostasis1.06432140
87MP0001849_ear_inflammation1.05976775
88MP0004019_abnormal_vitamin_homeostasis1.04581902
89MP0003566_abnormal_cell_adhesion1.04520397
90MP0002084_abnormal_developmental_patter1.03652695
91MP0002909_abnormal_adrenal_gland1.03067568
92MP0003868_abnormal_feces_composition1.02625919
93MP0004043_abnormal_pH_regulation1.02178347
94MP0000598_abnormal_liver_morphology1.01883075
95MP0002085_abnormal_embryonic_tissue1.00839239
96* MP0000759_abnormal_skeletal_muscle0.98783964
97MP0001727_abnormal_embryo_implantation0.98720428
98MP0003137_abnormal_impulse_conducting0.98288056
99MP0004808_abnormal_hematopoietic_stem0.97321547
100MP0008260_abnormal_autophagy0.94874423
101MP0004197_abnormal_fetal_growth/weight/0.93871797
102MP0005621_abnormal_cell_physiology0.91315929
103MP0002970_abnormal_white_adipose0.91072541
104MP0004272_abnormal_basement_membrane0.89782864
105MP0004484_altered_response_of0.88473123
106MP0000490_abnormal_crypts_of0.86888807
107MP0005409_darkened_coat_color0.86252538
108MP0000358_abnormal_cell_content/0.85645045
109MP0003567_abnormal_fetal_cardiomyocyte0.84265943
110MP0000604_amyloidosis0.84127002
111MP0002332_abnormal_exercise_endurance0.83859831
112MP0004085_abnormal_heartbeat0.83279371
113MP0002060_abnormal_skin_morphology0.83027220
114MP0005334_abnormal_fat_pad0.82749785
115MP0005369_muscle_phenotype0.82687467
116MP0005384_cellular_phenotype0.80786181
117MP0005451_abnormal_body_composition0.80683035
118MP0001915_intracranial_hemorrhage0.80587877
119MP0005535_abnormal_body_temperature0.80286273
120MP0003329_amyloid_beta_deposits0.80104138
121MP0005076_abnormal_cell_differentiation0.78608497
122MP0010368_abnormal_lymphatic_system0.78483453
123MP0005408_hypopigmentation0.77472032
124MP0004264_abnormal_extraembryonic_tissu0.76910935
125MP0003300_gastrointestinal_ulcer0.76802497
126MP0001764_abnormal_homeostasis0.76270742
127MP0001756_abnormal_urination0.75628396
128MP0009703_decreased_birth_body0.74176102
129MP0003950_abnormal_plasma_membrane0.73510742
130MP0000003_abnormal_adipose_tissue0.73164832
131MP0000678_abnormal_parathyroid_gland0.73062134
132MP0002166_altered_tumor_susceptibility0.72915134
133MP0002138_abnormal_hepatobiliary_system0.72581436
134MP0003186_abnormal_redox_activity0.71560061
135MP0003123_paternal_imprinting0.70967453
136MP0009672_abnormal_birth_weight0.70721474
137MP0000266_abnormal_heart_morphology0.70428059
138MP0004147_increased_porphyrin_level0.70013421
139MP0005636_abnormal_mineral_homeostasis0.69703017
140MP0001216_abnormal_epidermal_layer0.69592998
141MP0002877_abnormal_melanocyte_morpholog0.69488574
142MP0000579_abnormal_nail_morphology0.69441137
143MP0009115_abnormal_fat_cell0.69057177
144MP0000627_abnormal_mammary_gland0.67945533
145MP0002822_catalepsy0.67829056
146MP0005448_abnormal_energy_balance0.65955143
147MP0009642_abnormal_blood_homeostasis0.65747447
148MP0000013_abnormal_adipose_tissue0.64730415
149MP0005376_homeostasis/metabolism_phenot0.63712233
150MP0002088_abnormal_embryonic_growth/wei0.62523048
151MP0003984_embryonic_growth_retardation0.62472424
152MP0001730_embryonic_growth_arrest0.61400350
153MP0005187_abnormal_penis_morphology0.59224846
154MP0009763_increased_sensitivity_to0.58904698

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.67619467
2Nemaline bodies (HP:0003798)4.57287961
3Muscle fiber inclusion bodies (HP:0100299)4.56919452
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.53274262
5Myoglobinuria (HP:0002913)4.40364992
6Ketosis (HP:0001946)4.14504818
7Hyperammonemia (HP:0001987)4.14081834
8Centrally nucleated skeletal muscle fibers (HP:0003687)4.11558695
9Deep venous thrombosis (HP:0002625)4.04369572
10Ketoacidosis (HP:0001993)4.02615153
11Intrahepatic cholestasis (HP:0001406)3.98480604
12Hyperglycinuria (HP:0003108)3.93341335
13Xanthomatosis (HP:0000991)3.89395764
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.68850652
15Sudden death (HP:0001699)3.63796142
16Abnormality of fatty-acid metabolism (HP:0004359)3.63011087
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.60848653
18Exercise-induced muscle cramps (HP:0003710)3.52033074
19Abnormality of glycine metabolism (HP:0010895)3.50917206
20Abnormality of serine family amino acid metabolism (HP:0010894)3.50917206
21Rhabdomyolysis (HP:0003201)3.48396813
22Exercise-induced myalgia (HP:0003738)3.44015111
23Progressive muscle weakness (HP:0003323)3.42292272
24Hypobetalipoproteinemia (HP:0003563)3.38140526
25Hypoalphalipoproteinemia (HP:0003233)3.21405674
26Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20996489
27Dicarboxylic aciduria (HP:0003215)3.20996489
28Right ventricular cardiomyopathy (HP:0011663)3.20920756
29Hypolipoproteinemia (HP:0010981)3.14209993
30Hyperglycinemia (HP:0002154)3.13214408
31Ventricular tachycardia (HP:0004756)3.10251901
32Type 1 muscle fiber predominance (HP:0003803)3.09329142
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.09068338
34Myopathic facies (HP:0002058)3.07408379
35Progressive external ophthalmoplegia (HP:0000590)3.05653267
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.98154176
37EMG: myopathic abnormalities (HP:0003458)2.95979338
38Abnormality of glycolysis (HP:0004366)2.86154716
39Distal lower limb muscle weakness (HP:0009053)2.82805208
40Distal lower limb amyotrophy (HP:0008944)2.80213560
41Gout (HP:0001997)2.75643898
42Hyperlipoproteinemia (HP:0010980)2.75217145
43Cholelithiasis (HP:0001081)2.74167247
44Palpitations (HP:0001962)2.72017687
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.70586676
46Hyporeflexia of lower limbs (HP:0002600)2.70113689
47Asymmetric septal hypertrophy (HP:0001670)2.69722169
48Increased connective tissue (HP:0009025)2.67489964
49Complement deficiency (HP:0004431)2.65583798
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.63648610
51Ragged-red muscle fibers (HP:0003200)2.62795720
52Hyperacusis (HP:0010780)2.62608096
53Metabolic acidosis (HP:0001942)2.56026148
54Skin nodule (HP:0200036)2.55298854
55Hyperinsulinemic hypoglycemia (HP:0000825)2.54831685
56Epidermoid cyst (HP:0200040)2.53293367
57Abnormal gallbladder morphology (HP:0012437)2.51769918
58Late onset (HP:0003584)2.51476964
59Insidious onset (HP:0003587)2.48224436
60Termporal pattern (HP:0011008)2.48224436
61Abnormality of skeletal muscle fiber size (HP:0012084)2.46723260
62Shoulder girdle muscle weakness (HP:0003547)2.46619543
63Bundle branch block (HP:0011710)2.45630189
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45550321
65Atrioventricular block (HP:0001678)2.45397980
66Achilles tendon contracture (HP:0001771)2.45007603
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44519303
68Increased serum pyruvate (HP:0003542)2.43310360
69Abnormal gallbladder physiology (HP:0012438)2.41500017
70Cholecystitis (HP:0001082)2.41500017
71Generalized aminoaciduria (HP:0002909)2.40192998
72Lipoatrophy (HP:0100578)2.40138595
73Chromsome breakage (HP:0040012)2.39586871
74Neck muscle weakness (HP:0000467)2.37774375
75Reticulocytosis (HP:0001923)2.37713773
76Hyperbilirubinemia (HP:0002904)2.36663586
77Insomnia (HP:0100785)2.34357963
78Abnormality of purine metabolism (HP:0004352)2.33105958
79Rimmed vacuoles (HP:0003805)2.33009317
80Ankyloglossia (HP:0010296)2.32804810
81Pelvic girdle muscle weakness (HP:0003749)2.30312752
82Nausea (HP:0002018)2.29202802
83Abnormality of serum amino acid levels (HP:0003112)2.28558731
84Abnormal cartilage morphology (HP:0002763)2.26868932
85Muscle fiber splitting (HP:0003555)2.26378280
86Prolonged partial thromboplastin time (HP:0003645)2.25286162
87Hyperglycemia (HP:0003074)2.25200037
88Abnormality of the common coagulation pathway (HP:0010990)2.24609354
89Abnormality of the intrinsic pathway (HP:0010989)2.23180058
90Proximal tubulopathy (HP:0000114)2.23110856
91Difficulty running (HP:0009046)2.22860332
92Hypoglycemic seizures (HP:0002173)2.22013217
93Syncope (HP:0001279)2.19715670
94Ventricular arrhythmia (HP:0004308)2.18689096
95Atrial fibrillation (HP:0005110)2.18462700
96Abnormality of nucleobase metabolism (HP:0010932)2.18191542
97Multiple enchondromatosis (HP:0005701)2.18075563
98Lethargy (HP:0001254)2.17401391
99Heart block (HP:0012722)2.16834565
100Microvesicular hepatic steatosis (HP:0001414)2.15828050
101Cerebral edema (HP:0002181)2.14693989
102Calcaneovalgus deformity (HP:0001848)2.14158603
103Dilated cardiomyopathy (HP:0001644)2.13832928
104Calf muscle hypertrophy (HP:0008981)2.12215390
105Hydroxyprolinuria (HP:0003080)2.12199082
106Abnormality of proline metabolism (HP:0010907)2.12199082
107Abnormality of the salivary glands (HP:0010286)2.11653036
108Neonatal onset (HP:0003623)2.11364427
109Difficulty climbing stairs (HP:0003551)2.10933626
110Abnormality of the lower motor neuron (HP:0002366)2.09158570
111Spastic diplegia (HP:0001264)2.08102885
112Hepatocellular carcinoma (HP:0001402)2.07988402
113Abnormal atrioventricular conduction (HP:0005150)2.06343378
114Hypercholesterolemia (HP:0003124)2.05974027
115Abnormality of the Achilles tendon (HP:0005109)2.05892893
116Muscle stiffness (HP:0003552)2.05282250
117Increased purine levels (HP:0004368)2.05272737
118Hyperuricemia (HP:0002149)2.05272737
119Limb-girdle muscle atrophy (HP:0003797)2.04939254
120Global brain atrophy (HP:0002283)2.04475422
121Increased variability in muscle fiber diameter (HP:0003557)2.04388657
122Lower limb amyotrophy (HP:0007210)2.03693308
123Primary atrial arrhythmia (HP:0001692)2.03555718
124Lymphangioma (HP:0100764)2.02988895
125Abnormality of methionine metabolism (HP:0010901)2.02746322
126Abnormality of the calf musculature (HP:0001430)2.02686803
127Back pain (HP:0003418)2.01151802
128Subaortic stenosis (HP:0001682)2.00516704
129Abnormality of the left ventricular outflow tract (HP:0011103)2.00516704
130Abnormality of the calcaneus (HP:0008364)1.99751714
131Abnormality of complement system (HP:0005339)1.98345055
132Supraventricular tachycardia (HP:0004755)1.97664230
133Supraventricular arrhythmia (HP:0005115)1.97155268
134Trismus (HP:0000211)1.97010289
135Delayed CNS myelination (HP:0002188)1.96632972
136Conjunctival hamartoma (HP:0100780)1.95842014
137Scapular winging (HP:0003691)1.95557407
138Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94915129
139Muscle hypertrophy of the lower extremities (HP:0008968)1.93298915
140Asymmetry of the thorax (HP:0001555)1.92590616
141Increased nuchal translucency (HP:0010880)1.89873289
142Abnormality of the tricuspid valve (HP:0001702)1.87978186
143Mildly elevated creatine phosphokinase (HP:0008180)1.87717407
144Breech presentation (HP:0001623)1.84762370
145Abnormality of the musculature of the pelvis (HP:0001469)1.84541259
146Abnormality of the hip-girdle musculature (HP:0001445)1.84541259
147Deviation of the thumb (HP:0009603)1.79171731
148Abnormality of oral frenula (HP:0000190)1.75776222
149Fatigue (HP:0012378)1.75246548
150Flat acetabular roof (HP:0003180)1.75201894
151Selective tooth agenesis (HP:0001592)1.73717292
152Abnormality of the foot musculature (HP:0001436)1.72903427
153Deformed tarsal bones (HP:0008119)1.70131421
154Overriding aorta (HP:0002623)1.69674945
155Proximal placement of thumb (HP:0009623)1.68706517
156Foot dorsiflexor weakness (HP:0009027)1.68507896
157Abnormality of reticulocytes (HP:0004312)1.66637321
158Distal arthrogryposis (HP:0005684)1.65528819
159Orthostatic hypotension (HP:0001278)1.62197191
160EMG: neuropathic changes (HP:0003445)1.60713994
161Areflexia of lower limbs (HP:0002522)1.56275436
162Diaphragmatic weakness (HP:0009113)1.56015343
163Round ear (HP:0100830)1.53830482
164Osteolytic defects of the hand bones (HP:0009699)1.53368000
165Osteolytic defects of the phalanges of the hand (HP:0009771)1.53368000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.90798072
2TRIB34.65640981
3BCKDK4.11649988
4NEK13.11093993
5TTN3.05600678
6SMG12.82172831
7PDK42.80007738
8PDK32.80007738
9ERN12.51703138
10EIF2AK12.43435640
11TSSK62.36058546
12LMTK22.23013596
13CDC72.12814589
14SIK12.03050867
15PRPF4B1.98124630
16IRAK31.97462133
17NME21.97420332
18PBK1.86660313
19FLT31.85964950
20KSR21.77772957
21EEF2K1.76142734
22RIPK11.74161411
23SRPK11.68795782
24MAP3K101.57588701
25BUB11.55111247
26PHKG11.48821000
27PHKG21.48821000
28PTK61.37196903
29MAP3K71.33852962
30FGFR41.32578507
31OBSCN1.31462806
32MAPKAPK31.29485555
33PINK11.27131896
34TAOK11.25017676
35PDK21.23914228
36SCYL21.22610196
37CAMK1D1.22018478
38MAP2K31.19464134
39MET1.08557726
40LATS11.08477231
41PDGFRA1.08285398
42CDK121.07022439
43MAP3K91.01383223
44DMPK0.99503798
45MAP2K40.98813481
46CDK70.98272302
47LATS20.95774272
48MAPK110.94095645
49EIF2AK30.93636058
50MAP3K110.93545643
51ICK0.91879829
52CHEK10.91685901
53STK380.89833084
54PRKAA10.89777008
55MTOR0.89492618
56CHEK20.88133979
57MAP3K50.87792459
58PRKD30.86573275
59RET0.85721429
60WEE10.84979842
61PRKAA20.84246814
62CDK40.83208374
63AURKB0.82946232
64MAP3K30.80824592
65ALK0.80804532
66LRRK20.76030276
67PLK10.75438137
68JAK20.73312973
69CDK60.71157630
70BRD40.70885418
71ATR0.70205511
72TAF10.69887040
73MYLK0.69854958
74TRPM70.69455609
75KDR0.69269372
76BMX0.68351742
77CAMK1G0.65916997
78NEK90.64947928
79PAK60.64757477
80RAF10.63937377
81STK40.63242027
82CLK10.62733675
83MAP2K10.61920647
84CAMKK10.61787108
85BRAF0.61412115
86PDK10.61194128
87MAP3K10.60751817
88PDPK10.60720306
89PAK30.60531060
90RPS6KA40.60159466
91PTK20.59991384
92INSRR0.59348984
93MAP3K80.57788111
94STK38L0.56707470
95EPHA20.56416802
96GRK60.56397441
97MKNK10.55155473
98CDK20.54955772
99RPS6KB20.54116719
100NEK20.53629866
101AURKA0.53451181
102ARAF0.53048535
103CDK10.52978019
104PRKD10.52571568
105STK240.50737454
106CDC42BPA0.49235484
107ATM0.48532980
108BRSK20.48302633
109TTK0.47109413
110MAP3K60.46994059
111PAK40.46833591
112AKT20.46772559
113PRKACG0.46098242
114TAOK30.45605718
115MST1R0.45467417
116PRKG20.43716469
117MAP3K140.43533707
118FGFR10.43054941
119JAK10.42817550
120RPS6KB10.42725784
121TYK20.41872626
122MAPK120.41865664
123WNK40.41079350
124TESK20.40991714
125ILK0.40754100
126PIK3CA0.40612673
127ERBB40.39687921
128NTRK10.39612308
129MAP2K20.39440919
130NEK60.38857824
131CSNK1E0.38529274
132MAPK100.38344620
133MAP3K20.36920653
134BRSK10.36745786
135PLK30.36568532
136PIK3CG0.36363330
137RPS6KA10.34377859
138MAP3K130.33915898
139TAOK20.33395840
140PAK20.31982024
141STK30.31769486
142PRKDC0.31706530
143CSNK2A20.31520472
144DAPK20.31174902
145FER0.28855903
146CAMK40.28707925

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.91831961
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.88945903
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.73176437
4Fatty acid degradation_Homo sapiens_hsa000713.21618593
5Nitrogen metabolism_Homo sapiens_hsa009103.11262904
6DNA replication_Homo sapiens_hsa030303.06303341
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.94292227
8Propanoate metabolism_Homo sapiens_hsa006402.91315760
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82635825
10Arginine biosynthesis_Homo sapiens_hsa002202.71778127
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.69144494
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64896989
13Carbon metabolism_Homo sapiens_hsa012002.47079120
14Fatty acid metabolism_Homo sapiens_hsa012122.34067026
15Pyruvate metabolism_Homo sapiens_hsa006202.24511038
16Tryptophan metabolism_Homo sapiens_hsa003802.23200507
17Butanoate metabolism_Homo sapiens_hsa006502.09813668
18Biosynthesis of amino acids_Homo sapiens_hsa012302.03623706
19PPAR signaling pathway_Homo sapiens_hsa033202.01148744
20Mismatch repair_Homo sapiens_hsa034301.96538234
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74378778
22Cell cycle_Homo sapiens_hsa041101.72746081
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72047212
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68735647
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68592945
26Non-homologous end-joining_Homo sapiens_hsa034501.66239595
27Thyroid cancer_Homo sapiens_hsa052161.61886115
28RNA transport_Homo sapiens_hsa030131.58924618
29Selenocompound metabolism_Homo sapiens_hsa004501.56795138
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56147581
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.54321063
32Starch and sucrose metabolism_Homo sapiens_hsa005001.52071684
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51921105
34beta-Alanine metabolism_Homo sapiens_hsa004101.51211395
35Spliceosome_Homo sapiens_hsa030401.49900461
36Bile secretion_Homo sapiens_hsa049761.46937900
37Peroxisome_Homo sapiens_hsa041461.44552976
38Base excision repair_Homo sapiens_hsa034101.43709476
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.39223827
40Fat digestion and absorption_Homo sapiens_hsa049751.36523156
41Complement and coagulation cascades_Homo sapiens_hsa046101.34542416
42Nucleotide excision repair_Homo sapiens_hsa034201.33765174
43Lysine degradation_Homo sapiens_hsa003101.23248406
44mRNA surveillance pathway_Homo sapiens_hsa030151.22670374
45Chronic myeloid leukemia_Homo sapiens_hsa052201.19425173
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.16293613
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10007693
48Phenylalanine metabolism_Homo sapiens_hsa003601.07934389
49Caffeine metabolism_Homo sapiens_hsa002321.04044997
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.99996662
51Fatty acid biosynthesis_Homo sapiens_hsa000610.97411170
52Fructose and mannose metabolism_Homo sapiens_hsa000510.95359796
53Pentose phosphate pathway_Homo sapiens_hsa000300.95274979
54Galactose metabolism_Homo sapiens_hsa000520.93373270
55Arginine and proline metabolism_Homo sapiens_hsa003300.92368189
56Adherens junction_Homo sapiens_hsa045200.92335733
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90909953
58Glycerolipid metabolism_Homo sapiens_hsa005610.90152032
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89391977
60Endometrial cancer_Homo sapiens_hsa052130.87842477
61Chemical carcinogenesis_Homo sapiens_hsa052040.87379469
62Other glycan degradation_Homo sapiens_hsa005110.87123265
63Insulin resistance_Homo sapiens_hsa049310.86356535
64One carbon pool by folate_Homo sapiens_hsa006700.86225862
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85707798
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85084927
67Glucagon signaling pathway_Homo sapiens_hsa049220.84369807
68Non-small cell lung cancer_Homo sapiens_hsa052230.82275598
69Sulfur metabolism_Homo sapiens_hsa009200.80995307
70Pancreatic cancer_Homo sapiens_hsa052120.80202030
71Histidine metabolism_Homo sapiens_hsa003400.78626348
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.77923789
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77342585
74Folate biosynthesis_Homo sapiens_hsa007900.76673509
75Viral carcinogenesis_Homo sapiens_hsa052030.75304745
76Tyrosine metabolism_Homo sapiens_hsa003500.75190265
77Renal cell carcinoma_Homo sapiens_hsa052110.74662648
78ABC transporters_Homo sapiens_hsa020100.74388751
79Cardiac muscle contraction_Homo sapiens_hsa042600.72092164
80Small cell lung cancer_Homo sapiens_hsa052220.72043481
81Sulfur relay system_Homo sapiens_hsa041220.68271057
82MicroRNAs in cancer_Homo sapiens_hsa052060.67850383
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.67033180
84Acute myeloid leukemia_Homo sapiens_hsa052210.63808499
85Insulin signaling pathway_Homo sapiens_hsa049100.63762121
86AMPK signaling pathway_Homo sapiens_hsa041520.62484844
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61989692
88Dilated cardiomyopathy_Homo sapiens_hsa054140.61890095
89Tight junction_Homo sapiens_hsa045300.61288890
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60811158
91Proteasome_Homo sapiens_hsa030500.59992467
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59975656
93N-Glycan biosynthesis_Homo sapiens_hsa005100.59600198
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.59430597
95Pyrimidine metabolism_Homo sapiens_hsa002400.58941906
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56592705
97Prostate cancer_Homo sapiens_hsa052150.56058906
98Staphylococcus aureus infection_Homo sapiens_hsa051500.55324900
99Fatty acid elongation_Homo sapiens_hsa000620.54788918
100Retinol metabolism_Homo sapiens_hsa008300.54539151
101Glioma_Homo sapiens_hsa052140.54336795
102ErbB signaling pathway_Homo sapiens_hsa040120.49244970
103Colorectal cancer_Homo sapiens_hsa052100.48629651
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.47894000
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47500532
106Oocyte meiosis_Homo sapiens_hsa041140.46919810
107Proteoglycans in cancer_Homo sapiens_hsa052050.46544771
108VEGF signaling pathway_Homo sapiens_hsa043700.44436207
109Glutathione metabolism_Homo sapiens_hsa004800.41267140
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40395971
111Apoptosis_Homo sapiens_hsa042100.38746189
112mTOR signaling pathway_Homo sapiens_hsa041500.38134581
113Focal adhesion_Homo sapiens_hsa045100.37259180
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35782325
115Inositol phosphate metabolism_Homo sapiens_hsa005620.33785999
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33519414
117Metabolic pathways_Homo sapiens_hsa011000.33109573
118Type II diabetes mellitus_Homo sapiens_hsa049300.32625345
119p53 signaling pathway_Homo sapiens_hsa041150.30338128
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29112362
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28643736
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27345778
123Vitamin digestion and absorption_Homo sapiens_hsa049770.26167976
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26057103
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25638493
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23890657
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21647843
128HIF-1 signaling pathway_Homo sapiens_hsa040660.20899864
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.15979989
130Vitamin B6 metabolism_Homo sapiens_hsa007500.15866245
131Parkinsons disease_Homo sapiens_hsa050120.13509043
132Bladder cancer_Homo sapiens_hsa052190.10704047
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10447770
134Prion diseases_Homo sapiens_hsa050200.07357145
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.06675046
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03831940
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.00646891
138Viral myocarditis_Homo sapiens_hsa05416-0.0249953
139Protein digestion and absorption_Homo sapiens_hsa04974-0.0163614
140Renin-angiotensin system_Homo sapiens_hsa04614-0.0162345
141Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0055746

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