AFMID

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.63871028
2L-phenylalanine catabolic process (GO:0006559)7.63871028
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.32941416
4L-phenylalanine metabolic process (GO:0006558)7.32941416
5* aromatic amino acid family catabolic process (GO:0009074)6.88871780
6* tryptophan catabolic process (GO:0006569)6.16562161
7* indole-containing compound catabolic process (GO:0042436)6.16562161
8* indolalkylamine catabolic process (GO:0046218)6.16562161
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.05369163
10glyoxylate metabolic process (GO:0046487)5.96465309
11bile acid biosynthetic process (GO:0006699)5.90574909
12* kynurenine metabolic process (GO:0070189)5.82735290
13* tryptophan metabolic process (GO:0006568)5.81567287
14urea cycle (GO:0000050)5.66595772
15urea metabolic process (GO:0019627)5.66595772
16cysteine metabolic process (GO:0006534)5.57450141
17serine family amino acid catabolic process (GO:0009071)5.49558985
18behavioral response to nicotine (GO:0035095)5.47160931
19sulfur amino acid catabolic process (GO:0000098)5.45135737
20alpha-linolenic acid metabolic process (GO:0036109)5.41061385
21negative regulation of fibrinolysis (GO:0051918)5.39298605
22high-density lipoprotein particle remodeling (GO:0034375)5.38475937
23protein carboxylation (GO:0018214)5.22015291
24peptidyl-glutamic acid carboxylation (GO:0017187)5.22015291
25nitrogen cycle metabolic process (GO:0071941)5.21921439
26regulation of fibrinolysis (GO:0051917)5.18055724
27complement activation, alternative pathway (GO:0006957)5.11651345
28regulation of protein activation cascade (GO:2000257)5.06263186
29homocysteine metabolic process (GO:0050667)5.06066472
30bile acid metabolic process (GO:0008206)5.05984888
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.03606172
32* aromatic amino acid family metabolic process (GO:0009072)5.00770084
33lysine catabolic process (GO:0006554)4.96819853
34lysine metabolic process (GO:0006553)4.96819853
35tyrosine metabolic process (GO:0006570)4.87439000
36amino-acid betaine metabolic process (GO:0006577)4.85104155
37regulation of cholesterol esterification (GO:0010872)4.75953144
38* alpha-amino acid catabolic process (GO:1901606)4.74546116
39regulation of complement activation (GO:0030449)4.74289472
40glycine metabolic process (GO:0006544)4.67528389
41regulation of triglyceride catabolic process (GO:0010896)4.64041811
42reverse cholesterol transport (GO:0043691)4.61955642
43plasma lipoprotein particle remodeling (GO:0034369)4.55791931
44protein-lipid complex remodeling (GO:0034368)4.55791931
45macromolecular complex remodeling (GO:0034367)4.55791931
46negative regulation of sterol transport (GO:0032372)4.54325858
47negative regulation of cholesterol transport (GO:0032375)4.54325858
48water-soluble vitamin biosynthetic process (GO:0042364)4.48792140
49serine family amino acid metabolic process (GO:0009069)4.47449853
50cellular ketone body metabolic process (GO:0046950)4.46103191
51acylglycerol homeostasis (GO:0055090)4.44444095
52triglyceride homeostasis (GO:0070328)4.44444095
53phospholipid efflux (GO:0033700)4.41470286
54bile acid and bile salt transport (GO:0015721)4.38449056
55* cellular amino acid catabolic process (GO:0009063)4.37843280
56cellular glucuronidation (GO:0052695)4.31272484
57coenzyme catabolic process (GO:0009109)4.31216590
58imidazole-containing compound metabolic process (GO:0052803)4.30312352
59* indolalkylamine metabolic process (GO:0006586)4.27699814
60drug catabolic process (GO:0042737)4.27070077
61serine family amino acid biosynthetic process (GO:0009070)4.24862701
62glutamate metabolic process (GO:0006536)4.23632532
63plasma lipoprotein particle clearance (GO:0034381)4.20319640
64* cellular biogenic amine catabolic process (GO:0042402)4.15802521
65* amine catabolic process (GO:0009310)4.15802521
66cellular modified amino acid catabolic process (GO:0042219)4.14286909
67mitochondrial respiratory chain complex I assembly (GO:0032981)4.10824151
68NADH dehydrogenase complex assembly (GO:0010257)4.10824151
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10824151
70ethanol oxidation (GO:0006069)4.09148144
71* benzene-containing compound metabolic process (GO:0042537)4.07534094
72arginine metabolic process (GO:0006525)4.06571640
73cholesterol efflux (GO:0033344)4.03256118
74dicarboxylic acid biosynthetic process (GO:0043650)4.00956283
75aldehyde catabolic process (GO:0046185)4.00884989
76DNA deamination (GO:0045006)4.00509831
77sulfation (GO:0051923)3.91499822
78urate metabolic process (GO:0046415)3.90671925
79protein complex biogenesis (GO:0070271)3.90601075
80fibrinolysis (GO:0042730)3.87611078
81plasma lipoprotein particle assembly (GO:0034377)3.86961016
82short-chain fatty acid metabolic process (GO:0046459)3.86250005
83ketone body metabolic process (GO:1902224)3.86059580
84low-density lipoprotein particle remodeling (GO:0034374)3.85421930
85uronic acid metabolic process (GO:0006063)3.85116747
86glucuronate metabolic process (GO:0019585)3.85116747
87* carboxylic acid catabolic process (GO:0046395)3.84331602
88* organic acid catabolic process (GO:0016054)3.84331602
89exogenous drug catabolic process (GO:0042738)3.78598116
90regulation of bile acid biosynthetic process (GO:0070857)3.78159324
91acetyl-CoA metabolic process (GO:0006084)3.77554131
92drug transmembrane transport (GO:0006855)3.74731751
93cofactor catabolic process (GO:0051187)3.73514871
94phospholipid homeostasis (GO:0055091)3.70212581
95regulation of cholesterol homeostasis (GO:2000188)3.68501655
96blood coagulation, intrinsic pathway (GO:0007597)3.68359910
97cholesterol homeostasis (GO:0042632)3.68333575
98mitochondrial respiratory chain complex assembly (GO:0033108)3.67970672
99complement activation, classical pathway (GO:0006958)3.67007380
100very-low-density lipoprotein particle assembly (GO:0034379)3.64512568
101complement activation (GO:0006956)3.62999531
102sterol homeostasis (GO:0055092)3.62887482
1032-oxoglutarate metabolic process (GO:0006103)3.62704854
104positive regulation of lipoprotein lipase activity (GO:0051006)3.62082113
105positive regulation of triglyceride lipase activity (GO:0061365)3.62082113
106positive regulation of lipid catabolic process (GO:0050996)3.59895706
107aspartate family amino acid catabolic process (GO:0009068)3.58891410
108protein activation cascade (GO:0072376)3.57938307
109negative regulation of lipase activity (GO:0060192)3.56568566
110mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.56415627
111energy coupled proton transport, down electrochemical gradient (GO:0015985)3.54718371
112ATP synthesis coupled proton transport (GO:0015986)3.54718371
113L-fucose catabolic process (GO:0042355)3.49973849
114fucose catabolic process (GO:0019317)3.49973849
115L-fucose metabolic process (GO:0042354)3.49973849
116gamma-aminobutyric acid transport (GO:0015812)3.42287163
117nephron epithelium morphogenesis (GO:0072088)3.30148181
118nephron tubule morphogenesis (GO:0072078)3.30148181
119purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.29693768
1203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.29693768
121oxidative demethylation (GO:0070989)3.28729852
122mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.17779958
123mannosylation (GO:0097502)3.17204498
124intestinal cholesterol absorption (GO:0030299)3.12094994
125preassembly of GPI anchor in ER membrane (GO:0016254)3.10481877
126primary amino compound metabolic process (GO:1901160)3.09328265
127S-adenosylmethionine metabolic process (GO:0046500)2.96179630
128cellular response to ATP (GO:0071318)2.95610887
129maturation of 5.8S rRNA (GO:0000460)2.95495220
130amino acid salvage (GO:0043102)2.95451826
131L-methionine salvage (GO:0071267)2.95451826
132L-methionine biosynthetic process (GO:0071265)2.95451826
133GPI anchor metabolic process (GO:0006505)2.88673472
134flavonoid metabolic process (GO:0009812)2.86016186
135protein polyglutamylation (GO:0018095)2.84321919
136respiratory chain complex IV assembly (GO:0008535)2.83206285
137electron transport chain (GO:0022900)2.78852392
138positive regulation of fatty acid transport (GO:2000193)2.78824233
139respiratory electron transport chain (GO:0022904)2.74792442
140L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72381713
141negative regulation of telomere maintenance (GO:0032205)2.71642860
142cytochrome complex assembly (GO:0017004)2.65271263
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64395769
144protein-cofactor linkage (GO:0018065)2.62281626
145peptidyl-glutamic acid modification (GO:0018200)2.61622698
146serotonin metabolic process (GO:0042428)2.61366113
147pseudouridine synthesis (GO:0001522)2.58805464
148vitamin biosynthetic process (GO:0009110)2.57209039
149regulation of glucokinase activity (GO:0033131)2.56424079
150regulation of hexokinase activity (GO:1903299)2.56424079
151* indole-containing compound metabolic process (GO:0042430)2.52871572
152tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52210028
153RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52210028
154nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.49193911
155exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.47202776
156positive regulation of icosanoid secretion (GO:0032305)2.47040660
157detection of light stimulus involved in sensory perception (GO:0050962)2.45935942
158detection of light stimulus involved in visual perception (GO:0050908)2.45935942
159negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44232174
160regulation of gene silencing by RNA (GO:0060966)2.42783937
161regulation of posttranscriptional gene silencing (GO:0060147)2.42783937
162regulation of gene silencing by miRNA (GO:0060964)2.42783937
163transepithelial transport (GO:0070633)2.42691514
164dopamine transport (GO:0015872)2.42237652
165cellular anion homeostasis (GO:0030002)2.39815758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.34899293
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22840237
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.00337955
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.39272365
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.19247189
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.18100443
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84587854
8ZNF274_21170338_ChIP-Seq_K562_Hela4.13794160
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.11043816
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.89065760
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.18287170
12VDR_22108803_ChIP-Seq_LS180_Human2.97416546
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92570729
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.68895949
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.50651682
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49480517
17EZH2_22144423_ChIP-Seq_EOC_Human2.22967729
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21259783
19GBX2_23144817_ChIP-Seq_PC3_Human2.14156021
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12761049
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11078396
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.11013231
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10887615
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09970370
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09639057
26IGF1R_20145208_ChIP-Seq_DFB_Human2.08380818
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02676640
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8065943
29IRF1_19129219_ChIP-ChIP_H3396_Human1.97193383
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89884678
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88581940
32MYC_18940864_ChIP-ChIP_HL60_Human1.87163458
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.85448713
34* SRF_21415370_ChIP-Seq_HL-1_Mouse1.76274742
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73908343
36EWS_26573619_Chip-Seq_HEK293_Human1.69066577
37FUS_26573619_Chip-Seq_HEK293_Human1.68118546
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.64664321
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60571412
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59482429
41CLOCK_20551151_ChIP-Seq_293T_Human1.54980778
42VDR_23849224_ChIP-Seq_CD4+_Human1.49667089
43TP53_22573176_ChIP-Seq_HFKS_Human1.49474461
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.48842914
45GATA1_22025678_ChIP-Seq_K562_Human1.46634466
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.46402260
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46396688
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45932763
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.44252291
50HNF4A_19822575_ChIP-Seq_HepG2_Human1.42724862
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42701192
52ER_23166858_ChIP-Seq_MCF-7_Human1.41625297
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41456313
54HTT_18923047_ChIP-ChIP_STHdh_Human1.41320750
55* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40763285
56* FOXA1_25329375_ChIP-Seq_VCAP_Human1.40763285
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40548690
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39623980
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30544278
60NCOR_22424771_ChIP-Seq_293T_Human1.28704242
61TAF15_26573619_Chip-Seq_HEK293_Human1.28622026
62P300_19829295_ChIP-Seq_ESCs_Human1.27433736
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25484441
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.25483675
65RXRA_24833708_ChIP-Seq_LIVER_Mouse1.24875130
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.24461251
67ERA_21632823_ChIP-Seq_H3396_Human1.24096522
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23415813
69ELK1_19687146_ChIP-ChIP_HELA_Human1.23170871
70NANOG_19829295_ChIP-Seq_ESCs_Human1.20313282
71SOX2_19829295_ChIP-Seq_ESCs_Human1.20313282
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19988180
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19950592
74FOXP3_21729870_ChIP-Seq_TREG_Human1.19593676
75REST_21632747_ChIP-Seq_MESCs_Mouse1.19525509
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17182802
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.16849658
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16239096
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14412297
80RNF2_27304074_Chip-Seq_NSC_Mouse1.13890842
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13650359
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12195208
83HOXB7_26014856_ChIP-Seq_BT474_Human1.11316336
84TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10083197
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08109577
86* MYC_19829295_ChIP-Seq_ESCs_Human1.05610289
87BCAT_22108803_ChIP-Seq_LS180_Human1.05594228
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04156582
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04127022
90CBP_20019798_ChIP-Seq_JUKART_Human1.04127022
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02722865
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02188613
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98911474
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97768420
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.97737183
96AR_21572438_ChIP-Seq_LNCaP_Human0.97163002
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97085669
98TCF4_23295773_ChIP-Seq_U87_Human0.96962839
99NANOG_20526341_ChIP-Seq_ESCs_Human0.95784997
100STAT3_23295773_ChIP-Seq_U87_Human0.95344499
101EED_16625203_ChIP-ChIP_MESCs_Mouse0.94953829
102RAC3_21632823_ChIP-Seq_H3396_Human0.94832031
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94523022
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92377402
105OCT4_20526341_ChIP-Seq_ESCs_Human0.91240977
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.90016125
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89904815
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89819659
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89553876
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89326800
111PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89206297
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89073386
113AR_25329375_ChIP-Seq_VCAP_Human0.88978802
114CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88409570
115GABP_19822575_ChIP-Seq_HepG2_Human0.88405709
116RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87712556
117GATA4_25053715_ChIP-Seq_YYC3_Human0.86696536
118ZNF263_19887448_ChIP-Seq_K562_Human0.86103409
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83890997
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83208808
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82550995
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.82124802
123AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81160225
124* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78998856
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77896762
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77394258
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76699062
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76059361
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73519936
130RARB_24833708_ChIP-Seq_LIVER_Mouse0.71842427
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71595763
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70638978
133* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70575724
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66386753
135SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64512439
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.60110324
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.60043548
138CEBPB_22108803_ChIP-Seq_LS180_Human0.59805262
139* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55615358
140* GATA1_19941827_ChIP-Seq_MEL_Mouse0.54397762
141LXR_22292898_ChIP-Seq_THP-1_Human0.54174714
142AR_20517297_ChIP-Seq_VCAP_Human0.53672304
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.53570893
144EGR1_19032775_ChIP-ChIP_M12_Human0.52964940
145PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50416669
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50024751
147FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.49471088
148GATA6_25053715_ChIP-Seq_YYC3_Human0.48727514
149* MYC_19915707_ChIP-ChIP_AK7_Human0.48004155
150STAT1_17558387_ChIP-Seq_HELA_Human0.47698146
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.46903118
152FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.46759399
153GATA1_19941826_ChIP-Seq_K562_Human0.46507730
154ESR1_21235772_ChIP-Seq_MCF-7_Human0.46287136
155P53_21459846_ChIP-Seq_SAOS-2_Human0.45701547
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.45648742
157* FOXA1_25552417_ChIP-Seq_VCAP_Human0.45538106
158* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.45426075
159BRD4_27068464_Chip-Seq_AML-cells_Mouse0.44919253
160TAF2_19829295_ChIP-Seq_ESCs_Human0.44520679
161PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.44156363
162NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.43457280
163GATA2_19941826_ChIP-Seq_K562_Human0.43349967
164CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.43271457
165NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.43249929
166NRF2_20460467_ChIP-Seq_MEFs_Mouse0.43249929
167IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.42451057
168PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41502449
169CBP_21632823_ChIP-Seq_H3396_Human0.40490780
170BCOR_27268052_Chip-Seq_Bcells_Human0.39751263
171SPI1_26923725_Chip-Seq_HPCs_Mouse0.39251140
172SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.39012440
173IRF8_27001747_Chip-Seq_BMDM_Mouse0.38775550
174* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.38695814
175PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.38517912
176FOXO3_23340844_ChIP-Seq_DLD1_Human0.38381073
177SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.37976302
178CDX2_20551321_ChIP-Seq_CACO-2_Human0.37674077
179SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37617505
180PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37118374
181RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.36632502
182* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35626067
183STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.35180920
184CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.34923922
185LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34516965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.15905301
2MP0005360_urolithiasis7.60901353
3MP0005085_abnormal_gallbladder_physiolo6.27977327
4MP0005365_abnormal_bile_salt6.04378339
5MP0008875_abnormal_xenobiotic_pharmacok5.13076917
6MP0003806_abnormal_nucleotide_metabolis4.17069020
7MP0003252_abnormal_bile_duct3.80545619
8MP0010329_abnormal_lipoprotein_level3.44605206
9MP0009840_abnormal_foam_cell3.27398741
10MP0005332_abnormal_amino_acid2.96318705
11MP0003195_calcinosis2.93231637
12MP0005083_abnormal_biliary_tract2.90627677
13MP0006292_abnormal_olfactory_placode2.68431336
14MP0001666_abnormal_nutrient_absorption2.51836145
15MP0004019_abnormal_vitamin_homeostasis2.34867544
16MP0003191_abnormal_cellular_cholesterol2.23898335
17MP0000609_abnormal_liver_physiology2.17702024
18MP0002138_abnormal_hepatobiliary_system2.15410688
19MP0005646_abnormal_pituitary_gland2.14321518
20MP0005551_abnormal_eye_electrophysiolog2.07469323
21MP0002118_abnormal_lipid_homeostasis2.03546405
22MP0005319_abnormal_enzyme/_coenzyme1.87472411
23MP0003868_abnormal_feces_composition1.81973927
24MP0002938_white_spotting1.80624338
25MP0001764_abnormal_homeostasis1.75766374
26MP0002160_abnormal_reproductive_system1.75096742
27MP0009046_muscle_twitch1.74249938
28MP0001485_abnormal_pinna_reflex1.67820699
29MP0003122_maternal_imprinting1.65469761
30MP0005451_abnormal_body_composition1.65108492
31MP0001968_abnormal_touch/_nociception1.64628777
32MP0004142_abnormal_muscle_tone1.61905847
33MP0005584_abnormal_enzyme/coenzyme_acti1.59039765
34MP0003646_muscle_fatigue1.58067531
35MP0008877_abnormal_DNA_methylation1.56464002
36MP0000372_irregular_coat_pigmentation1.53299573
37MP0009697_abnormal_copulation1.52910309
38MP0004145_abnormal_muscle_electrophysio1.47084675
39MP0009643_abnormal_urine_homeostasis1.46077110
40MP0004885_abnormal_endolymph1.43757554
41MP0003186_abnormal_redox_activity1.43312582
42MP0002102_abnormal_ear_morphology1.38762719
43MP0003656_abnormal_erythrocyte_physiolo1.37689503
44MP0002638_abnormal_pupillary_reflex1.35792649
45MP0009745_abnormal_behavioral_response1.35056863
46MP0003136_yellow_coat_color1.34133448
47MP0002272_abnormal_nervous_system1.32150000
48MP0000631_abnormal_neuroendocrine_gland1.29800340
49MP0005389_reproductive_system_phenotype1.27106483
50MP0006072_abnormal_retinal_apoptosis1.25981824
51MP0004133_heterotaxia1.25858493
52MP0001986_abnormal_taste_sensitivity1.24089086
53MP0000598_abnormal_liver_morphology1.22446159
54MP0002736_abnormal_nociception_after1.22297810
55MP0005645_abnormal_hypothalamus_physiol1.18879824
56MP0003011_delayed_dark_adaptation1.15889199
57MP0002163_abnormal_gland_morphology1.15676298
58MP0009764_decreased_sensitivity_to1.11707649
59MP0005410_abnormal_fertilization1.11687905
60MP0002735_abnormal_chemical_nociception1.11356682
61MP0004742_abnormal_vestibular_system1.08771115
62MP0005377_hearing/vestibular/ear_phenot1.08013299
63MP0003878_abnormal_ear_physiology1.08013299
64MP0005253_abnormal_eye_physiology1.07768467
65MP0004147_increased_porphyrin_level1.07187655
66MP0005636_abnormal_mineral_homeostasis1.06929203
67MP0005647_abnormal_sex_gland1.06737505
68MP0009763_increased_sensitivity_to1.04811690
69MP0006276_abnormal_autonomic_nervous1.04141688
70MP0003705_abnormal_hypodermis_morpholog1.02874110
71MP0008469_abnormal_protein_level1.00221067
72MP0002064_seizures0.99461599
73MP0002282_abnormal_trachea_morphology0.98839513
74MP0000566_synostosis0.98653757
75MP0002653_abnormal_ependyma_morphology0.97169550
76MP0003119_abnormal_digestive_system0.96799764
77MP0003121_genomic_imprinting0.95139904
78MP0005379_endocrine/exocrine_gland_phen0.95010428
79MP0001529_abnormal_vocalization0.94962149
80MP0000604_amyloidosis0.94544549
81MP0001486_abnormal_startle_reflex0.94542690
82MP0002234_abnormal_pharynx_morphology0.93309761
83MP0005195_abnormal_posterior_eye0.92762744
84MP0005408_hypopigmentation0.92685854
85MP0002557_abnormal_social/conspecific_i0.92500296
86MP0005167_abnormal_blood-brain_barrier0.90224669
87MP0006036_abnormal_mitochondrial_physio0.90220247
88MP0009642_abnormal_blood_homeostasis0.90182750
89MP0001905_abnormal_dopamine_level0.89587040
90MP0000049_abnormal_middle_ear0.89290347
91MP0002254_reproductive_system_inflammat0.89028756
92MP0002733_abnormal_thermal_nociception0.87905304
93MP0003787_abnormal_imprinting0.87262718
94MP0002876_abnormal_thyroid_physiology0.86212773
95MP0005084_abnormal_gallbladder_morpholo0.83368508
96MP0001293_anophthalmia0.82395280
97MP0008058_abnormal_DNA_repair0.81594351
98MP0009765_abnormal_xenobiotic_induced0.80390868
99MP0005670_abnormal_white_adipose0.79897378
100MP0001919_abnormal_reproductive_system0.78521338
101MP0001501_abnormal_sleep_pattern0.77902029
102MP0005376_homeostasis/metabolism_phenot0.77640081
103MP0001756_abnormal_urination0.77502568
104MP0010368_abnormal_lymphatic_system0.76019113
105MP0001970_abnormal_pain_threshold0.75555631
106MP0003698_abnormal_male_reproductive0.74624164
107MP0002078_abnormal_glucose_homeostasis0.74463647
108MP0001661_extended_life_span0.74382830
109MP0003283_abnormal_digestive_organ0.74358416
110MP0008775_abnormal_heart_ventricle0.74037909
111MP0000026_abnormal_inner_ear0.73893774
112MP0009384_cardiac_valve_regurgitation0.73268238
113MP0001963_abnormal_hearing_physiology0.72831713
114MP0002067_abnormal_sensory_capabilities0.72272708
115MP0005220_abnormal_exocrine_pancreas0.71226881
116MP0001929_abnormal_gametogenesis0.71161907
117MP0002572_abnormal_emotion/affect_behav0.71158375
118MP0000653_abnormal_sex_gland0.70327935
119MP0002971_abnormal_brown_adipose0.66868055
120MP0005334_abnormal_fat_pad0.66517759
121MP0002136_abnormal_kidney_physiology0.66353088
122MP0003718_maternal_effect0.64453837
123MP0005266_abnormal_metabolism0.64214254
124MP0005535_abnormal_body_temperature0.63615904
125MP0005464_abnormal_platelet_physiology0.61829545
126MP0006035_abnormal_mitochondrial_morpho0.61484302
127MP0004130_abnormal_muscle_cell0.60246553
128MP0003436_decreased_susceptibility_to0.59541189
129MP0005395_other_phenotype0.57686383
130MP0009053_abnormal_anal_canal0.56909457
131MP0003724_increased_susceptibility_to0.52043345
132MP0003690_abnormal_glial_cell0.50644157
133MP0005058_abnormal_lysosome_morphology0.49333922
134MP0002928_abnormal_bile_duct0.48709466
135MP0003329_amyloid_beta_deposits0.48638690
136MP0006082_CNS_inflammation0.48424803
137MP0005448_abnormal_energy_balance0.47268915
138MP0000639_abnormal_adrenal_gland0.46991474
139MP0004782_abnormal_surfactant_physiolog0.46242914
140MP0008873_increased_physiological_sensi0.44665236
141MP0001845_abnormal_inflammatory_respons0.43079235
142MP0003638_abnormal_response/metabolism_0.42663982
143MP0009672_abnormal_birth_weight0.41263629
144MP0001853_heart_inflammation0.39888687
145MP0008874_decreased_physiological_sensi0.39435828
146MP0003953_abnormal_hormone_level0.38856513
147MP0002822_catalepsy0.37582470
148MP0002168_other_aberrant_phenotype0.36615079
149MP0004043_abnormal_pH_regulation0.36366558
150MP0008872_abnormal_physiological_respon0.36268374
151MP0004381_abnormal_hair_follicle0.35482590
152MP0005666_abnormal_adipose_tissue0.35335639
153MP0005166_decreased_susceptibility_to0.35076465
154MP0002132_abnormal_respiratory_system0.34263589
155MP0009115_abnormal_fat_cell0.33550042
156MP0009785_altered_susceptibility_to0.32813412
157MP0000230_abnormal_systemic_arterial0.31811284
158MP0003075_altered_response_to0.31302329
159MP0000249_abnormal_blood_vessel0.31160997
160MP0002837_dystrophic_cardiac_calcinosis0.29934772
161MP0002970_abnormal_white_adipose0.29109425
162MP0002135_abnormal_kidney_morphology0.28976416
163MP0001243_abnormal_dermal_layer0.28956588
164MP0001765_abnormal_ion_homeostasis0.28587023
165MP0000685_abnormal_immune_system0.28341598
166MP0004947_skin_inflammation0.27962675
167MP0001835_abnormal_antigen_presentation0.27837649
168MP0001881_abnormal_mammary_gland0.27409750

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.33629315
2Intrahepatic cholestasis (HP:0001406)6.99794723
3Deep venous thrombosis (HP:0002625)6.99338930
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.59670873
5Prolonged partial thromboplastin time (HP:0003645)6.19680606
6Xanthomatosis (HP:0000991)6.07107772
7Hypobetalipoproteinemia (HP:0003563)6.06597384
8Hyperlipoproteinemia (HP:0010980)5.30707334
9Complement deficiency (HP:0004431)4.97040819
10Hyperglycinemia (HP:0002154)4.76966366
11Joint hemorrhage (HP:0005261)4.69239918
12Hyperammonemia (HP:0001987)4.67697999
13Hypolipoproteinemia (HP:0010981)4.53166954
14Hyperglycinuria (HP:0003108)4.43401004
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.40226562
16Abnormality of sulfur amino acid metabolism (HP:0004339)4.36999338
17Ketosis (HP:0001946)4.29011240
18Abnormality of serine family amino acid metabolism (HP:0010894)4.28853746
19Abnormality of glycine metabolism (HP:0010895)4.28853746
20Epidermoid cyst (HP:0200040)4.27979192
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.27178706
22Abnormality of methionine metabolism (HP:0010901)4.26267219
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.14774164
24Abnormality of the common coagulation pathway (HP:0010990)4.11981088
25Abnormality of pyrimidine metabolism (HP:0004353)4.00941408
26Fat malabsorption (HP:0002630)4.00930212
27Pancreatic cysts (HP:0001737)3.95975655
28Hypoalphalipoproteinemia (HP:0003233)3.95540557
29Hypoglycemic coma (HP:0001325)3.74133667
30Pancreatic fibrosis (HP:0100732)3.67711143
31Abnormality of complement system (HP:0005339)3.61438333
32True hermaphroditism (HP:0010459)3.59865321
33Conjugated hyperbilirubinemia (HP:0002908)3.57145893
34Abnormality of the intrinsic pathway (HP:0010989)3.55454126
35Abnormality of fatty-acid metabolism (HP:0004359)3.51200657
36Pendular nystagmus (HP:0012043)3.50732666
37Hypercholesterolemia (HP:0003124)3.46818542
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38465917
39Congenital stationary night blindness (HP:0007642)3.37156418
40Hyperbilirubinemia (HP:0002904)3.33098680
41Abnormality of serum amino acid levels (HP:0003112)3.32026090
42Abnormality of nucleobase metabolism (HP:0010932)3.31839778
43Delayed CNS myelination (HP:0002188)3.15567114
44Molar tooth sign on MRI (HP:0002419)3.11497017
45Abnormality of midbrain morphology (HP:0002418)3.11497017
46Ketoacidosis (HP:0001993)3.07280261
47Steatorrhea (HP:0002570)3.06767274
48Gout (HP:0001997)2.99287235
49Myocardial infarction (HP:0001658)2.98329441
50Hepatocellular carcinoma (HP:0001402)2.97316351
51Abnormality of purine metabolism (HP:0004352)2.97288963
52Nephronophthisis (HP:0000090)2.96336576
53Type II lissencephaly (HP:0007260)2.92990238
54Mitochondrial inheritance (HP:0001427)2.88678029
55Metabolic acidosis (HP:0001942)2.87368156
56Hypochromic microcytic anemia (HP:0004840)2.85287535
57Increased CSF lactate (HP:0002490)2.79020949
58Abolished electroretinogram (ERG) (HP:0000550)2.77975030
59Acute necrotizing encephalopathy (HP:0006965)2.77414982
60Dicarboxylic aciduria (HP:0003215)2.77110159
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.77110159
62Lethargy (HP:0001254)2.76067546
63Abnormality of the renal cortex (HP:0011035)2.74734861
64Vascular calcification (HP:0004934)2.73603783
65Systemic lupus erythematosus (HP:0002725)2.73164227
66Acute encephalopathy (HP:0006846)2.71822068
67Hepatocellular necrosis (HP:0001404)2.71601282
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69252707
69Abnormality of alanine metabolism (HP:0010916)2.69252707
70Hyperalaninemia (HP:0003348)2.69252707
713-Methylglutaconic aciduria (HP:0003535)2.69194659
72Spontaneous abortion (HP:0005268)2.67887971
73Hepatic necrosis (HP:0002605)2.66296066
74Skin nodule (HP:0200036)2.57519340
75Hypothermia (HP:0002045)2.56028039
76Cystic liver disease (HP:0006706)2.55231835
77Decreased central vision (HP:0007663)2.53733878
78Abnormal mitochondria in muscle tissue (HP:0008316)2.51617917
79Methylmalonic acidemia (HP:0002912)2.50855260
80Keratoconus (HP:0000563)2.49990857
81Increased corneal curvature (HP:0100692)2.49990857
82Irritability (HP:0000737)2.49072011
83Spastic diplegia (HP:0001264)2.44872838
84Mitral stenosis (HP:0001718)2.43683180
85Abnormality of the renal medulla (HP:0100957)2.43225841
86Acanthocytosis (HP:0001927)2.42148201
87Cardiovascular calcification (HP:0011915)2.40879525
88Congenital, generalized hypertrichosis (HP:0004540)2.40625671
89Glomerulonephritis (HP:0000099)2.40436404
90Cerebral edema (HP:0002181)2.39911664
91Generalized aminoaciduria (HP:0002909)2.37536671
92Neonatal onset (HP:0003623)2.37341917
93Sclerocornea (HP:0000647)2.37092097
94Abnormal gallbladder morphology (HP:0012437)2.33201747
95Recurrent gram-negative bacterial infections (HP:0005420)2.30682729
96Lipid accumulation in hepatocytes (HP:0006561)2.30161443
97Progressive macrocephaly (HP:0004481)2.28890712
98Cholelithiasis (HP:0001081)2.28500532
99Hypoglycemic seizures (HP:0002173)2.28448423
100Malnutrition (HP:0004395)2.27090573
101Genetic anticipation (HP:0003743)2.23692076
102Abnormal number of erythroid precursors (HP:0012131)2.21480278
103Methylmalonic aciduria (HP:0012120)2.21063952
104Increased serum lactate (HP:0002151)2.20376578
105Furrowed tongue (HP:0000221)2.17891538
106Increased hepatocellular lipid droplets (HP:0006565)2.17727417
107Bile duct proliferation (HP:0001408)2.16980045
108Abnormal biliary tract physiology (HP:0012439)2.16980045
109Vomiting (HP:0002013)2.16893642
110Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16471136
111Pancreatitis (HP:0001733)2.15998228
112Alkalosis (HP:0001948)2.15364344
113Esophageal varix (HP:0002040)2.15000585
114Gingival bleeding (HP:0000225)2.13154645
115Attenuation of retinal blood vessels (HP:0007843)2.12908446
116Brushfield spots (HP:0001088)2.11055879
117Proximal tubulopathy (HP:0000114)2.10715750
118Late onset (HP:0003584)2.10543607
119Sensorimotor neuropathy (HP:0007141)2.09605135
120Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08943204
121Enlarged kidneys (HP:0000105)2.08534471
122Menorrhagia (HP:0000132)2.07417574
123Poikilocytosis (HP:0004447)2.07190884
124Opisthotonus (HP:0002179)2.07079975
125Abnormal rod and cone electroretinograms (HP:0008323)2.05300416
126Thrombophlebitis (HP:0004418)2.04390972
127Rickets (HP:0002748)2.03588647
128Male pseudohermaphroditism (HP:0000037)2.02953985
129Abnormal gallbladder physiology (HP:0012438)2.02020704
130Cholecystitis (HP:0001082)2.02020704
131Abnormality of proline metabolism (HP:0010907)2.01699148
132Hydroxyprolinuria (HP:0003080)2.01699148
133Hyperuricemia (HP:0002149)2.01001085
134Increased purine levels (HP:0004368)2.01001085
135Amyloidosis (HP:0011034)1.99638438
136Progressive cerebellar ataxia (HP:0002073)1.99094564
137Renal cortical cysts (HP:0000803)1.98939278
138Concave nail (HP:0001598)1.96949356
139Hypoplasia of the pons (HP:0012110)1.96710705
140Abnormal enzyme/coenzyme activity (HP:0012379)1.96277510
141Abnormality of the renal collecting system (HP:0004742)1.95396533
142Chorioretinal atrophy (HP:0000533)1.93499102
143Absent thumb (HP:0009777)1.93051382
144Medial flaring of the eyebrow (HP:0010747)1.92864899
145Glycosuria (HP:0003076)1.92833015
146Abnormality of urine glucose concentration (HP:0011016)1.92833015
147Abnormality of iron homeostasis (HP:0011031)1.92816897
148Abnormality of transition element cation homeostasis (HP:0011030)1.92740003
149Hemorrhage of the eye (HP:0011885)1.92389630
150Abnormality of the pons (HP:0007361)1.92355886
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.91979701
152Abnormality of cells of the erythroid lineage (HP:0012130)1.90913723
153Abnormal cartilage morphology (HP:0002763)1.90856397
154Confusion (HP:0001289)1.90033353
155Abnormality of the gallbladder (HP:0005264)1.90004647
156Lactic acidosis (HP:0003128)1.89392387
157Meckel diverticulum (HP:0002245)1.89356965
158Optic disc pallor (HP:0000543)1.87697310
159Polydipsia (HP:0001959)1.87288446
160Abnormal drinking behavior (HP:0030082)1.87288446
161Aplasia/Hypoplasia of the patella (HP:0006498)1.87231159
162Abnormality of the ileum (HP:0001549)1.86881472
163Tubular atrophy (HP:0000092)1.86770600
164Elevated hepatic transaminases (HP:0002910)1.85790824
165Aplasia/Hypoplasia of the tongue (HP:0010295)1.82711637
166Severe muscular hypotonia (HP:0006829)1.82558084
167Birth length less than 3rd percentile (HP:0003561)1.82511490
168Inability to walk (HP:0002540)1.82375125
169Chronic hepatic failure (HP:0100626)1.82286764
170Lissencephaly (HP:0001339)1.81119651
171Abnormality of the nasal septum (HP:0000419)1.80934037
172Hypophosphatemic rickets (HP:0004912)1.80759071
173Congenital hepatic fibrosis (HP:0002612)1.76418268
174Patellar aplasia (HP:0006443)1.73471062
175Cerebellar dysplasia (HP:0007033)1.73022110
176Gaze-evoked nystagmus (HP:0000640)1.70726293
177Aplasia/Hypoplasia of the uvula (HP:0010293)1.70356977
178Duplicated collecting system (HP:0000081)1.67866126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.15169197
2FGFR44.85794505
3SIK14.16289914
4ERN13.87788387
5ZAK3.70133038
6ADRBK23.41177855
7TLK13.27943096
8WNK43.25092201
9BMPR1B3.21389272
10TAOK32.98884739
11INSRR2.71236623
12MAP4K22.65046994
13ERBB42.38451456
14VRK22.37657188
15TYK22.28933880
16PKN22.14803994
17FLT31.96192701
18ACVR1B1.95566153
19MAPK111.92362841
20MST1R1.85724472
21VRK11.78262239
22TRIB31.75343500
23MAP2K41.74972321
24NEK91.64955636
25MAP3K141.63482650
26PIK3CG1.57538671
27TBK11.57024925
28MAPK131.56201796
29STK391.48524549
30OXSR11.48237036
31LATS11.47091929
32MAPKAPK31.44231223
33PTK61.35559499
34KDR1.34949411
35ABL21.34359798
36JAK11.32999277
37STK38L1.32323104
38MAPKAPK51.32294442
39IRAK31.29008678
40PIK3CA1.28281387
41PINK11.24831358
42MAP2K31.24425348
43JAK21.23608695
44GRK61.22997214
45MAP4K11.19253077
46IKBKE1.19238973
47MAP3K41.13382983
48MAP3K71.10918553
49PRKAA21.10595826
50PRKCG1.10315092
51DYRK21.08265092
52NME11.07851645
53FRK1.00839886
54DAPK20.99683622
55ADRBK10.96066612
56MAP3K30.94981582
57MAP3K100.90965041
58MAPK40.90476867
59RPS6KA50.90456382
60TXK0.89801043
61CASK0.89308703
62MKNK20.83330379
63NTRK30.83064238
64CDK60.81189077
65CDC70.81017223
66TGFBR10.79999555
67PRKCZ0.79510166
68BRSK20.79491736
69CSF1R0.79384699
70CSK0.78747519
71MAP3K110.77477729
72ERBB20.77183259
73SGK30.77102806
74DYRK1B0.76733807
75FGFR20.75932232
76CDK80.74623905
77PRKAA10.74432224
78CSNK1G30.73182345
79MAP2K70.73145267
80PLK30.71743978
81WEE10.71335043
82MAP2K60.71148439
83TAF10.70030712
84CSNK1A1L0.69798774
85CAMKK20.68362346
86MAPK120.68218657
87PRKCI0.66654657
88PNCK0.66283870
89PRKACG0.66279447
90EPHB10.66240568
91MUSK0.65997116
92PIM20.65893503
93PHKG20.65292268
94PHKG10.65292268
95PLK40.65254689
96CDK40.65064945
97PAK30.65063330
98PLK20.64949051
99ATR0.63777485
100PRKCE0.63508264
101FGFR30.63170131
102TGFBR20.62654329
103PDK40.62051316
104PDK30.62051316
105EPHA30.60984647
106CHEK20.60927236
107TIE10.60924661
108NEK20.59735815
109GSK3A0.59570749
110EPHA40.58932974
111SGK20.58382032
112CSNK1G20.58160642
113TRIM280.56947322
114MAP3K130.56552880
115TAOK20.55443868
116ZAP700.55270239
117MAPK150.54077652
118PRKACA0.53417635
119IKBKB0.53331249
120CSNK1A10.52269692
121KIT0.51949531
122EIF2AK30.51474581
123PRKCQ0.51472958
124NTRK20.50726358
125MAP3K50.49792982
126SIK20.49748429
127CHUK0.49473963
128CAMK2G0.49169506
129NEK10.49021846
130GRK50.47823373
131PLK10.46973616
132MAPK70.46065543
133BUB10.45741048
134JAK30.45322363
135PDPK10.45238064
136CSNK1D0.43524589
137CSNK2A10.43256735
138AURKA0.42790525
139GRK70.42160683
140MKNK10.40942824
141STK30.39430296
142IGF1R0.39283640
143SRPK10.39264630
144NME20.39063649
145CSNK1G10.38885209
146CAMK1D0.38786947
147STK160.38719364
148GRK10.38570826
149DAPK10.37884206
150MST40.37499943
151ITK0.37289788
152MAP2K20.36379668
153AKT30.35641696
154CSNK1E0.35416347
155PTK20.35106913
156PRKCA0.34994895
157MET0.34977282
158SGK4940.34824247
159SGK2230.34824247
160CAMK2A0.34661840
161CSNK2A20.34295609
162BTK0.34212081
163PKN10.34169034
164WNK30.33558284
165PIM10.33348121
166PDK10.33343333
167PTK2B0.33241224
168MTOR0.32371793
169BLK0.30917834
170EIF2AK10.29568568
171NUAK10.27752357
172MAP2K10.27164071
173LYN0.27015930
174EGFR0.26266041

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39347161
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44878641
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44440866
4Nitrogen metabolism_Homo sapiens_hsa009103.28377018
5Arginine biosynthesis_Homo sapiens_hsa002203.00234011
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.63236021
7* Tryptophan metabolism_Homo sapiens_hsa003802.61803652
8* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59994061
9Complement and coagulation cascades_Homo sapiens_hsa046102.59395046
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56983719
11Fatty acid degradation_Homo sapiens_hsa000712.48643357
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44162546
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39691614
14Oxidative phosphorylation_Homo sapiens_hsa001902.35036635
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29142845
16Butanoate metabolism_Homo sapiens_hsa006502.20281848
17Peroxisome_Homo sapiens_hsa041462.12354927
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12223159
19Propanoate metabolism_Homo sapiens_hsa006401.97093821
20Chemical carcinogenesis_Homo sapiens_hsa052041.93792336
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92933124
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.91169508
23Parkinsons disease_Homo sapiens_hsa050121.90207558
24Histidine metabolism_Homo sapiens_hsa003401.90118175
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.87993103
26PPAR signaling pathway_Homo sapiens_hsa033201.80922228
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79435628
28beta-Alanine metabolism_Homo sapiens_hsa004101.78692766
29Fatty acid metabolism_Homo sapiens_hsa012121.77313726
30Caffeine metabolism_Homo sapiens_hsa002321.76276613
31Homologous recombination_Homo sapiens_hsa034401.73912028
32RNA polymerase_Homo sapiens_hsa030201.72295125
33Staphylococcus aureus infection_Homo sapiens_hsa051501.71267810
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70316208
35Retinol metabolism_Homo sapiens_hsa008301.68062811
36Selenocompound metabolism_Homo sapiens_hsa004501.65468238
37Phototransduction_Homo sapiens_hsa047441.65300213
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62216780
39Phenylalanine metabolism_Homo sapiens_hsa003601.58839071
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58653434
41Ribosome_Homo sapiens_hsa030101.58382930
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48029000
43Protein export_Homo sapiens_hsa030601.46576371
44Bile secretion_Homo sapiens_hsa049761.43792377
45Tyrosine metabolism_Homo sapiens_hsa003501.39669020
46Pyruvate metabolism_Homo sapiens_hsa006201.38248141
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.37163322
48Sulfur metabolism_Homo sapiens_hsa009201.34005438
49Folate biosynthesis_Homo sapiens_hsa007901.32999568
50Fanconi anemia pathway_Homo sapiens_hsa034601.28646114
51Starch and sucrose metabolism_Homo sapiens_hsa005001.28244813
52Fatty acid elongation_Homo sapiens_hsa000621.24341105
53Biosynthesis of amino acids_Homo sapiens_hsa012301.24171562
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23548050
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22140557
56Huntingtons disease_Homo sapiens_hsa050161.20744959
57Nicotine addiction_Homo sapiens_hsa050331.18856901
58ABC transporters_Homo sapiens_hsa020101.17892686
59Carbon metabolism_Homo sapiens_hsa012001.17556898
60Vitamin B6 metabolism_Homo sapiens_hsa007501.17278397
61Alzheimers disease_Homo sapiens_hsa050101.16665849
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14904720
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.12826023
64Steroid biosynthesis_Homo sapiens_hsa001001.12044148
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08225623
66Fat digestion and absorption_Homo sapiens_hsa049751.05006662
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03347875
68Arginine and proline metabolism_Homo sapiens_hsa003301.02067939
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01688902
70Sulfur relay system_Homo sapiens_hsa041221.00296398
71Vitamin digestion and absorption_Homo sapiens_hsa049770.97454545
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.97015264
73Ether lipid metabolism_Homo sapiens_hsa005650.95258898
74Proteasome_Homo sapiens_hsa030500.94138820
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93637085
76RNA degradation_Homo sapiens_hsa030180.90614270
77Basal transcription factors_Homo sapiens_hsa030220.90350068
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90307269
79Cardiac muscle contraction_Homo sapiens_hsa042600.88991184
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87305506
81One carbon pool by folate_Homo sapiens_hsa006700.86669357
82Lysine degradation_Homo sapiens_hsa003100.84797091
83Glutathione metabolism_Homo sapiens_hsa004800.72449845
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69033992
85Glycerolipid metabolism_Homo sapiens_hsa005610.66307471
86Purine metabolism_Homo sapiens_hsa002300.66114648
87Pentose phosphate pathway_Homo sapiens_hsa000300.65193312
88DNA replication_Homo sapiens_hsa030300.61969801
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59063022
90Taste transduction_Homo sapiens_hsa047420.57973086
91Olfactory transduction_Homo sapiens_hsa047400.52947766
92Nucleotide excision repair_Homo sapiens_hsa034200.52374339
93* Metabolic pathways_Homo sapiens_hsa011000.47834732
94Mineral absorption_Homo sapiens_hsa049780.47522796
95Morphine addiction_Homo sapiens_hsa050320.44502625
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41589387
97Fatty acid biosynthesis_Homo sapiens_hsa000610.39485464
98Asthma_Homo sapiens_hsa053100.38554718
99Base excision repair_Homo sapiens_hsa034100.38477377
100GABAergic synapse_Homo sapiens_hsa047270.36930510
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36678037
102Serotonergic synapse_Homo sapiens_hsa047260.34660727
103Fructose and mannose metabolism_Homo sapiens_hsa000510.30008707
104Prion diseases_Homo sapiens_hsa050200.25967405
105Galactose metabolism_Homo sapiens_hsa000520.24451753
106Insulin resistance_Homo sapiens_hsa049310.21403337
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21079692
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.20400835
109Linoleic acid metabolism_Homo sapiens_hsa005910.17085982
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.17072452
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13978264
112Regulation of autophagy_Homo sapiens_hsa041400.02944546
113Glucagon signaling pathway_Homo sapiens_hsa049220.02734666
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00063800
115Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2389051
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2298021
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2279971
118Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2256287
119Lysosome_Homo sapiens_hsa04142-0.2141938
120Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2137486
121African trypanosomiasis_Homo sapiens_hsa05143-0.1881905
122Pyrimidine metabolism_Homo sapiens_hsa00240-0.1821577
123Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1780093
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1768217
125Renin-angiotensin system_Homo sapiens_hsa04614-0.1629956
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1583283
127Hepatitis C_Homo sapiens_hsa05160-0.1433399
128Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1411770
129Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1372711
130Insulin signaling pathway_Homo sapiens_hsa04910-0.1336518
131Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1332475
132Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1065510
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0592143
134AMPK signaling pathway_Homo sapiens_hsa04152-0.0067491

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