AFP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reverse cholesterol transport (GO:0043691)9.17695809
2high-density lipoprotein particle remodeling (GO:0034375)8.65158974
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)8.43220120
4plasma lipoprotein particle assembly (GO:0034377)8.20996272
5protoporphyrinogen IX metabolic process (GO:0046501)8.02240797
6protoporphyrinogen IX biosynthetic process (GO:0006782)7.73973885
7plasma lipoprotein particle remodeling (GO:0034369)7.68479810
8protein-lipid complex remodeling (GO:0034368)7.68479810
9macromolecular complex remodeling (GO:0034367)7.68479810
10plasma lipoprotein particle clearance (GO:0034381)7.66883303
11negative regulation of fibrinolysis (GO:0051918)7.58485823
12protein-lipid complex assembly (GO:0065005)7.53094690
13regulation of cholesterol esterification (GO:0010872)7.45427318
14phospholipid efflux (GO:0033700)7.36951868
15cholesterol efflux (GO:0033344)6.95843438
16regulation of fibrinolysis (GO:0051917)6.87779884
17negative regulation of protein activation cascade (GO:2000258)6.87462734
18regulation of plasminogen activation (GO:0010755)6.56273061
19plasma lipoprotein particle organization (GO:0071827)6.54828709
20lipoprotein metabolic process (GO:0042157)6.30161064
21protein-lipid complex subunit organization (GO:0071825)6.26122472
22intestinal cholesterol absorption (GO:0030299)6.21504838
23blood coagulation, intrinsic pathway (GO:0007597)6.01217091
24negative regulation of complement activation (GO:0045916)5.90826378
25positive regulation of triglyceride lipase activity (GO:0061365)5.72424748
26positive regulation of lipoprotein lipase activity (GO:0051006)5.72424748
27phospholipid homeostasis (GO:0055091)5.54545164
28regulation of triglyceride catabolic process (GO:0010896)5.38803578
29regulation of cytokine secretion involved in immune response (GO:0002739)5.36785720
30glyoxylate metabolic process (GO:0046487)5.30694032
31regulation of lipoprotein metabolic process (GO:0050746)5.17505469
32heme biosynthetic process (GO:0006783)5.10693817
33porphyrin-containing compound biosynthetic process (GO:0006779)4.95289566
34regulation of protein activation cascade (GO:2000257)4.83430812
35triglyceride homeostasis (GO:0070328)4.76556269
36acylglycerol homeostasis (GO:0055090)4.76556269
37very-low-density lipoprotein particle assembly (GO:0034379)4.70501177
38cholesterol homeostasis (GO:0042632)4.65556109
39heme metabolic process (GO:0042168)4.65457442
40peptidyl-glutamic acid carboxylation (GO:0017187)4.59268953
41protein carboxylation (GO:0018214)4.59268953
42fibrinolysis (GO:0042730)4.58027370
43sterol homeostasis (GO:0055092)4.57517704
44diacylglycerol metabolic process (GO:0046339)4.52377969
45low-density lipoprotein particle remodeling (GO:0034374)4.50465786
46regulation of cholesterol homeostasis (GO:2000188)4.47364831
47porphyrin-containing compound metabolic process (GO:0006778)4.37607474
48tetrapyrrole biosynthetic process (GO:0033014)4.35662373
49sterol transport (GO:0015918)4.34351268
50cholesterol transport (GO:0030301)4.34351268
51acylglycerol catabolic process (GO:0046464)4.29347153
52neutral lipid catabolic process (GO:0046461)4.29347153
53regulation of complement activation (GO:0030449)4.27206532
54intestinal absorption (GO:0050892)4.25575634
55positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.25042264
56regulation of lipoprotein particle clearance (GO:0010984)4.24739157
57positive regulation of Rho protein signal transduction (GO:0035025)4.22841359
58negative regulation of humoral immune response (GO:0002921)4.07709926
59positive regulation of lipid catabolic process (GO:0050996)4.06508850
60negative regulation of hemostasis (GO:1900047)3.98956090
61negative regulation of blood coagulation (GO:0030195)3.98956090
62L-phenylalanine catabolic process (GO:0006559)3.95560766
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.95560766
64sulfur amino acid catabolic process (GO:0000098)3.94990470
65negative regulation of cholesterol transport (GO:0032375)3.94299073
66negative regulation of sterol transport (GO:0032372)3.94299073
67regulation of heterotypic cell-cell adhesion (GO:0034114)3.92483190
68positive regulation of fatty acid biosynthetic process (GO:0045723)3.89511202
69L-phenylalanine metabolic process (GO:0006558)3.88827290
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.88827290
71positive regulation of triglyceride metabolic process (GO:0090208)3.88518946
72vitamin D metabolic process (GO:0042359)3.87163276
73hemoglobin metabolic process (GO:0020027)3.83477503
74protein autoprocessing (GO:0016540)3.77493896
75negative regulation of sodium ion transport (GO:0010766)3.74893248
76nephron tubule morphogenesis (GO:0072078)3.70810514
77nephron epithelium morphogenesis (GO:0072088)3.70810514
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.67520936
79serine family amino acid biosynthetic process (GO:0009070)3.67206421
80positive regulation of blood coagulation (GO:0030194)3.66468236
81positive regulation of hemostasis (GO:1900048)3.66468236
82low-density lipoprotein particle clearance (GO:0034383)3.65209504
83glutamine family amino acid biosynthetic process (GO:0009084)3.64224044
84negative regulation of coagulation (GO:0050819)3.62567620
85negative regulation of wound healing (GO:0061045)3.60506070
86iron ion import (GO:0097286)3.60414583
87regulation of apoptotic cell clearance (GO:2000425)3.57676979
88regulation of bile acid biosynthetic process (GO:0070857)3.56799410
89negative regulation of lipase activity (GO:0060192)3.56688169
90regulation of cholesterol biosynthetic process (GO:0045540)3.55473852
91positive regulation of steroid metabolic process (GO:0045940)3.53568175
92tetrapyrrole metabolic process (GO:0033013)3.50103648
93embryonic retina morphogenesis in camera-type eye (GO:0060059)3.48460854
944-hydroxyproline metabolic process (GO:0019471)3.45692614
95COPII vesicle coating (GO:0048208)3.44002942
96positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)3.43883132
97erythrocyte maturation (GO:0043249)3.40952574
98cellular ketone body metabolic process (GO:0046950)3.39260761
99positive regulation of coagulation (GO:0050820)3.36975603
100regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.36486012
101lysine catabolic process (GO:0006554)3.35461213
102lysine metabolic process (GO:0006553)3.35461213
103dicarboxylic acid biosynthetic process (GO:0043650)3.32500864
104galactose catabolic process (GO:0019388)3.32387065
105amino-acid betaine metabolic process (GO:0006577)3.32099334
106L-alpha-amino acid transmembrane transport (GO:1902475)3.30907635
107protein activation cascade (GO:0072376)3.28544866
108heme transport (GO:0015886)3.28539922
109glycerolipid catabolic process (GO:0046503)3.27542133
110regulation of G0 to G1 transition (GO:0070316)3.27188457
111lipid homeostasis (GO:0055088)3.27013115
112lipoprotein transport (GO:0042953)3.23384528
113negative regulation of endothelial cell apoptotic process (GO:2000352)3.23348631
114cholesterol metabolic process (GO:0008203)3.23236075
115response to methylmercury (GO:0051597)3.19919265
116negative regulation of lipid transport (GO:0032369)3.13731556
117regulation of sterol transport (GO:0032371)3.12461356
118regulation of cholesterol transport (GO:0032374)3.12461356
119cholesterol biosynthetic process (GO:0006695)3.12316408
120L-ascorbic acid metabolic process (GO:0019852)3.12201039
121regulation of substrate adhesion-dependent cell spreading (GO:1900024)3.11686925
122glutamate metabolic process (GO:0006536)3.10443366
123proline metabolic process (GO:0006560)3.10368526
124triglyceride catabolic process (GO:0019433)3.09147793
125urea cycle (GO:0000050)3.08925101
126urea metabolic process (GO:0019627)3.08925101
127glycine metabolic process (GO:0006544)3.08496456
128regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.06967958
129positive regulation of extracellular matrix organization (GO:1903055)3.06492907
130oligosaccharide catabolic process (GO:0009313)3.05414953
131acute-phase response (GO:0006953)3.05371353
132proline biosynthetic process (GO:0006561)2.96641868
133lung epithelium development (GO:0060428)2.96294902
134regulation of fatty acid biosynthetic process (GO:0042304)2.91566411
135sterol metabolic process (GO:0016125)2.90582562
136COPI coating of Golgi vesicle (GO:0048205)2.87685688
137Golgi transport vesicle coating (GO:0048200)2.87685688
138regulation of cholesterol metabolic process (GO:0090181)2.86597403
139negative regulation of fatty acid biosynthetic process (GO:0045717)2.85004582
140regulation of non-canonical Wnt signaling pathway (GO:2000050)2.78780369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.23784147
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.40510928
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.11353477
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.32376256
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.01918047
6GATA1_22025678_ChIP-Seq_K562_Human3.90495992
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78263819
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.39753507
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.33447312
10GATA1_19941826_ChIP-Seq_K562_Human3.33209640
11PRDM5_23873026_ChIP-Seq_MEFs_Mouse3.00184117
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.91554263
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.89690192
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.77070528
15ESR1_15608294_ChIP-ChIP_MCF-7_Human2.74187588
16CLOCK_20551151_ChIP-Seq_293T_Human2.70893741
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62799788
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.62113766
19E2F7_22180533_ChIP-Seq_HELA_Human2.56542939
20CDX2_20551321_ChIP-Seq_CACO-2_Human2.45358120
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40798288
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32017217
23TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.31549256
24GATA1_19941827_ChIP-Seq_MEL_Mouse2.25384135
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.19573575
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.13853234
27ZNF263_19887448_ChIP-Seq_K562_Human2.09239191
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.09166515
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.99354732
30CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91833852
31GATA2_19941826_ChIP-Seq_K562_Human1.88611120
32SALL4_18804426_ChIP-ChIP_XEN_Mouse1.82618272
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77556250
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74329630
35KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.71311475
36AR_21909140_ChIP-Seq_LNCAP_Human1.66081632
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64736331
38GATA1_22383799_ChIP-Seq_G1ME_Mouse1.62953586
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55557460
40* FOXA2_19822575_ChIP-Seq_HepG2_Human1.52144014
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42258911
42SCL_19346495_ChIP-Seq_HPC-7_Human1.36541280
43LXR_22292898_ChIP-Seq_THP-1_Human1.35829827
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28681825
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.28304231
46FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27654579
47TP53_16413492_ChIP-PET_HCT116_Human1.27628203
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27511831
49SOX17_20123909_ChIP-Seq_XEN_Mouse1.25037117
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22029858
51TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18807607
52* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18803570
53EOMES_21245162_ChIP-Seq_HESCs_Human1.16987866
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16625089
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15375909
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14846687
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.13220661
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09106653
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07687353
60NCOR1_26117541_ChIP-Seq_K562_Human1.06893451
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06273982
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05473207
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.04687152
64GATA6_25053715_ChIP-Seq_YYC3_Human1.04453571
65GATA4_25053715_ChIP-Seq_YYC3_Human1.04183329
66STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03892734
67RACK7_27058665_Chip-Seq_MCF-7_Human1.03671580
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.01807241
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.00903754
70* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00417321
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.00186048
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99510454
73STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98903717
74KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97416775
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96307412
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93391214
77ERG_21242973_ChIP-ChIP_JURKAT_Human0.92605098
78FOXA1_25552417_ChIP-Seq_VCAP_Human0.92340964
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91971135
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90974301
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90925895
82NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90680259
83SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90609712
84ELF1_20517297_ChIP-Seq_JURKAT_Human0.88360732
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87745410
86RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87074167
87POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86787636
88EGR1_19032775_ChIP-ChIP_M12_Human0.85077352
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84593450
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.83606097
91BCOR_27268052_Chip-Seq_Bcells_Human0.83542844
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82463720
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82081629
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81058565
95TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80771595
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80141506
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79700708
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.79651808
99PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79373198
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79128546
101EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78125695
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77817930
103SOX11_22085726_ChIP-Seq_ESNs_Mouse0.77744096
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77327614
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76104283
106P68_20966046_ChIP-Seq_HELA_Human0.73663635
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73490058
108RBPJ_22232070_ChIP-Seq_NCS_Mouse0.73421861
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73412294
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73159942
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.73027744
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72739819
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72252141
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.72164692
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72026618
116ATF3_27146783_Chip-Seq_COLON_Human0.71709609
117MYC_22102868_ChIP-Seq_BL_Human0.69935971
118SMAD1_18555785_Chip-Seq_ESCs_Mouse0.69688931
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.69596136
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69459025
121CTCF_27219007_Chip-Seq_Bcells_Human0.68481677
122ZNF274_21170338_ChIP-Seq_K562_Hela0.68066760
123SOX2_20726797_ChIP-Seq_SW620_Human0.67485008
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.67451550
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.67014396
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65762885
127BCL6_27268052_Chip-Seq_Bcells_Human0.65649272
128ZFX_18555785_Chip-Seq_ESCs_Mouse0.65469632
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.65324278
130SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.64818958
131TCF3_18692474_ChIP-Seq_MEFs_Mouse0.64652517
132GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64649100
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64264961
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.63972257
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.63556716
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.62959892
137CTCF_21964334_Chip-Seq_Bcells_Human0.62830615
138ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.61592353
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.61518829
140TP53_22127205_ChIP-Seq_IMR90_Human0.61133985
141ZFX_18555785_ChIP-Seq_MESCs_Mouse0.61015941
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60156085
143SOX2_22085726_ChIP-Seq_NPCs_Mouse0.59069509
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58218491
145SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.57519092
146TCF3_18692474_ChIP-Seq_MESCs_Mouse0.56766143
147CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.56481125
148NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.55911069
149STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.55891909
150CEBPB_22108803_ChIP-Seq_LS180_Human0.54871338
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53377019
152* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.53348963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.10916698
2MP0003656_abnormal_erythrocyte_physiolo4.82866588
3MP0003122_maternal_imprinting4.57663911
4MP0004147_increased_porphyrin_level4.57145833
5MP0003191_abnormal_cellular_cholesterol4.40530798
6MP0009840_abnormal_foam_cell4.39351897
7MP0010368_abnormal_lymphatic_system4.28587717
8MP0003123_paternal_imprinting4.02708904
9MP0004264_abnormal_extraembryonic_tissu3.85960194
10MP0010329_abnormal_lipoprotein_level3.69384988
11MP0002139_abnormal_hepatobiliary_system3.28379907
12MP0005365_abnormal_bile_salt3.16610748
13MP0005085_abnormal_gallbladder_physiolo2.95812905
14MP0005083_abnormal_biliary_tract2.84438904
15MP0004272_abnormal_basement_membrane2.79883271
16MP0004019_abnormal_vitamin_homeostasis2.60291832
17MP0002089_abnormal_postnatal_growth/wei2.52251421
18MP0000566_synostosis2.39668046
19MP0003121_genomic_imprinting2.14388301
20MP0002876_abnormal_thyroid_physiology2.08655153
21MP0006054_spinal_hemorrhage2.04615591
22MP0001986_abnormal_taste_sensitivity2.01931679
23MP0003011_delayed_dark_adaptation2.01742699
24MP0001666_abnormal_nutrient_absorption1.82332099
25MP0000609_abnormal_liver_physiology1.76575420
26MP0008438_abnormal_cutaneous_collagen1.65483833
27MP0000604_amyloidosis1.65279044
28MP0003705_abnormal_hypodermis_morpholog1.64700837
29MP0003566_abnormal_cell_adhesion1.61219537
30MP0002254_reproductive_system_inflammat1.61086191
31MP0005409_darkened_coat_color1.60761852
32MP0003941_abnormal_skin_development1.59177530
33MP0003806_abnormal_nucleotide_metabolis1.57799474
34MP0005464_abnormal_platelet_physiology1.57030292
35MP0005332_abnormal_amino_acid1.56668274
36MP0005636_abnormal_mineral_homeostasis1.56366129
37MP0003252_abnormal_bile_duct1.54642055
38MP0002938_white_spotting1.53639966
39MP0003315_abnormal_perineum_morphology1.50129085
40MP0005167_abnormal_blood-brain_barrier1.49908236
41MP0009643_abnormal_urine_homeostasis1.45160319
42MP0009697_abnormal_copulation1.42013699
43MP0004883_abnormal_blood_vessel1.41128236
44MP0002118_abnormal_lipid_homeostasis1.39884823
45MP0003950_abnormal_plasma_membrane1.35493279
46MP0002138_abnormal_hepatobiliary_system1.30393629
47MP0004270_analgesia1.29877126
48MP0009780_abnormal_chondrocyte_physiolo1.29581709
49MP0003567_abnormal_fetal_cardiomyocyte1.29469514
50MP0000598_abnormal_liver_morphology1.24332170
51MP0005084_abnormal_gallbladder_morpholo1.20002086
52MP0002132_abnormal_respiratory_system1.17276774
53MP0008875_abnormal_xenobiotic_pharmacok1.13991506
54MP0005164_abnormal_response_to1.13904693
55MP0001915_intracranial_hemorrhage1.12639451
56MP0001270_distended_abdomen1.11686588
57MP0001879_abnormal_lymphatic_vessel1.06332909
58MP0002086_abnormal_extraembryonic_tissu1.04401425
59MP0005257_abnormal_intraocular_pressure1.04001598
60MP0003878_abnormal_ear_physiology1.03080024
61MP0005377_hearing/vestibular/ear_phenot1.03080024
62MP0005584_abnormal_enzyme/coenzyme_acti0.99456569
63MP0005023_abnormal_wound_healing0.99424169
64MP0009053_abnormal_anal_canal0.97494484
65MP0001764_abnormal_homeostasis0.96985378
66MP0009384_cardiac_valve_regurgitation0.95005625
67MP0005670_abnormal_white_adipose0.93929726
68MP0000639_abnormal_adrenal_gland0.93898911
69MP0005319_abnormal_enzyme/_coenzyme0.93662763
70MP0005058_abnormal_lysosome_morphology0.93648383
71MP0003890_abnormal_embryonic-extraembry0.93229952
72MP0003942_abnormal_urinary_system0.92316512
73MP0005408_hypopigmentation0.91808487
74MP0002796_impaired_skin_barrier0.88876161
75MP0004185_abnormal_adipocyte_glucose0.86617823
76MP0008775_abnormal_heart_ventricle0.86473395
77MP0002909_abnormal_adrenal_gland0.85664846
78MP0004197_abnormal_fetal_growth/weight/0.85418710
79MP0001756_abnormal_urination0.83823983
80MP0003329_amyloid_beta_deposits0.83619652
81MP0005376_homeostasis/metabolism_phenot0.82879862
82MP0003632_abnormal_nervous_system0.82373104
83MP0005551_abnormal_eye_electrophysiolog0.82004263
84MP0003868_abnormal_feces_composition0.81452078
85MP0005501_abnormal_skin_physiology0.81029013
86MP0009672_abnormal_birth_weight0.80932366
87MP0005187_abnormal_penis_morphology0.80668641
88MP0005275_abnormal_skin_tensile0.80462416
89MP0001243_abnormal_dermal_layer0.77332497
90MP0001324_abnormal_eye_pigmentation0.76934184
91MP0005410_abnormal_fertilization0.76676039
92MP0000920_abnormal_myelination0.73682844
93MP0003186_abnormal_redox_activity0.73000426
94MP0009333_abnormal_splenocyte_physiolog0.72620759
95MP0002697_abnormal_eye_size0.71231926
96MP0003303_peritoneal_inflammation0.70892255
97MP0001661_extended_life_span0.70305803
98MP0002136_abnormal_kidney_physiology0.69222204
99* MP0009642_abnormal_blood_homeostasis0.69154910
100MP0005451_abnormal_body_composition0.68574498
101MP0009931_abnormal_skin_appearance0.67543110
102MP0002090_abnormal_vision0.67100100
103MP0003195_calcinosis0.65480225
104MP0003115_abnormal_respiratory_system0.64194962
105MP0002128_abnormal_blood_circulation0.63730720
106MP0001730_embryonic_growth_arrest0.63680052
107MP0003385_abnormal_body_wall0.62160581
108MP0008469_abnormal_protein_level0.60853465
109MP0001293_anophthalmia0.59858433
110MP0008260_abnormal_autophagy0.59089806
111MP0000249_abnormal_blood_vessel0.59003549
112MP0001299_abnormal_eye_distance/0.58722240
113MP0003943_abnormal_hepatobiliary_system0.58186703
114MP0002295_abnormal_pulmonary_circulatio0.57055147
115MP0003172_abnormal_lysosome_physiology0.56054338
116MP0002135_abnormal_kidney_morphology0.55928364
117MP0009763_increased_sensitivity_to0.55717003
118MP0005220_abnormal_exocrine_pancreas0.55542488
119MP0003879_abnormal_hair_cell0.55425252
120MP0000465_gastrointestinal_hemorrhage0.55423408
121MP0002092_abnormal_eye_morphology0.54732933
122MP0005379_endocrine/exocrine_gland_phen0.54552092
123MP0002233_abnormal_nose_morphology0.54551292
124MP0006036_abnormal_mitochondrial_physio0.53737746
125MP0001286_abnormal_eye_development0.53556784
126* MP0003699_abnormal_female_reproductive0.51965466
127* MP0003953_abnormal_hormone_level0.51761813
128MP0000371_diluted_coat_color0.51346562
129MP0003718_maternal_effect0.50497753
130MP0005076_abnormal_cell_differentiation0.49190314
131MP0003984_embryonic_growth_retardation0.46063927
132MP0008872_abnormal_physiological_respon0.45371090
133MP0002088_abnormal_embryonic_growth/wei0.45206682
134MP0002332_abnormal_exercise_endurance0.44998838
135MP0001614_abnormal_blood_vessel0.42993191
136* MP0002078_abnormal_glucose_homeostasis0.42910879
137MP0003075_altered_response_to0.42910260
138MP0005165_increased_susceptibility_to0.42561971
139MP0005385_cardiovascular_system_phenoty0.40812972
140MP0001544_abnormal_cardiovascular_syste0.40812972
141MP0004084_abnormal_cardiac_muscle0.38817581
142MP0001697_abnormal_embryo_size0.38311245
143MP0005380_embryogenesis_phenotype0.37765664
144MP0001672_abnormal_embryogenesis/_devel0.37765664
145MP0009764_decreased_sensitivity_to0.37592209

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.86366140
2Acanthocytosis (HP:0001927)6.57439885
3Poikilocytosis (HP:0004447)6.14758580
4Abnormality of the heme biosynthetic pathway (HP:0010472)6.11696100
5Xanthomatosis (HP:0000991)5.51942179
6Hypoalphalipoproteinemia (HP:0003233)5.35994414
7Confusion (HP:0001289)5.27117952
8Hypochromic microcytic anemia (HP:0004840)5.08230963
9Joint hemorrhage (HP:0005261)4.97469218
10Hypolipoproteinemia (HP:0010981)4.94678430
11Prolonged partial thromboplastin time (HP:0003645)4.94497503
12Abnormality of the common coagulation pathway (HP:0010990)4.77083840
13Reticulocytosis (HP:0001923)4.46753237
14Hypobetalipoproteinemia (HP:0003563)4.25234006
15Pancreatic islet-cell hyperplasia (HP:0004510)4.19676399
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.12267181
17Hypoglycemic coma (HP:0001325)4.10748429
18Amyloidosis (HP:0011034)4.01326804
19Spontaneous abortion (HP:0005268)3.93487153
20Hyperbilirubinemia (HP:0002904)3.82835902
21Osteomalacia (HP:0002749)3.81900487
22Broad alveolar ridges (HP:0000187)3.80508897
23Abnormality of carpal bone ossification (HP:0006257)3.66790517
24Cholelithiasis (HP:0001081)3.65286189
25Hepatocellular carcinoma (HP:0001402)3.64449074
26Abnormal tarsal ossification (HP:0008369)3.62801427
27Intrahepatic cholestasis (HP:0001406)3.57135168
28Megaloblastic anemia (HP:0001889)3.56864457
29Hepatoblastoma (HP:0002884)3.53355772
30Gingival bleeding (HP:0000225)3.46560972
31Abnormality of aromatic amino acid family metabolism (HP:0004338)3.45875621
32Abnormality of the intrinsic pathway (HP:0010989)3.43359167
33Abnormal gallbladder physiology (HP:0012438)3.42672928
34Cholecystitis (HP:0001082)3.42672928
35Abnormal gallbladder morphology (HP:0012437)3.40129792
36Broad palm (HP:0001169)3.31013395
37Polycythemia (HP:0001901)3.26249898
38Paralysis (HP:0003470)3.24182984
39Abnormality of the nasal septum (HP:0000419)3.13713203
40Retinal atrophy (HP:0001105)3.10546966
41Diastasis recti (HP:0001540)3.09267842
42Abnormality of glutamine family amino acid metabolism (HP:0010902)3.07202925
43Thrombophlebitis (HP:0004418)3.06127251
44Flat acetabular roof (HP:0003180)2.99686473
45Ileus (HP:0002595)2.98914042
46Hypoglycemic seizures (HP:0002173)2.94529159
47Nonimmune hydrops fetalis (HP:0001790)2.90625765
48Hemorrhage of the eye (HP:0011885)2.90105766
49Small epiphyses (HP:0010585)2.87395716
50Abnormality of the pancreatic islet cells (HP:0006476)2.82818350
51Abnormality of endocrine pancreas physiology (HP:0012093)2.82818350
52Pigmentary retinal degeneration (HP:0001146)2.79982402
53Vacuolated lymphocytes (HP:0001922)2.77852201
54Vascular calcification (HP:0004934)2.75225926
55Abnormality of reticulocytes (HP:0004312)2.74557871
56Menorrhagia (HP:0000132)2.74192141
57Spontaneous hematomas (HP:0007420)2.71663635
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.71472996
59Abnormal hand bone ossification (HP:0010660)2.70008935
60Esophageal varix (HP:0002040)2.69888977
61Microcytic anemia (HP:0001935)2.68962272
62Diaphragmatic weakness (HP:0009113)2.68073983
63Hyperammonemia (HP:0001987)2.68072564
64Flared iliac wings (HP:0002869)2.66644202
65Abnormal ossification of hand bones (HP:0005921)2.66348354
66Purpura (HP:0000979)2.64781280
67Alacrima (HP:0000522)2.60123274
68Increased serum pyruvate (HP:0003542)2.58041475
69Epistaxis (HP:0000421)2.57514092
70Hypercholesterolemia (HP:0003124)2.56239832
71Abnormality of transition element cation homeostasis (HP:0011030)2.55992561
72Abnormality of the gallbladder (HP:0005264)2.52186030
73Abnormality of the lumbar spine (HP:0100712)2.51369806
74Abnormality of sulfur amino acid metabolism (HP:0004339)2.48838536
75Arthropathy (HP:0003040)2.47821251
76Conjunctival telangiectasia (HP:0000524)2.46217787
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.45857917
78Cardiovascular calcification (HP:0011915)2.42084926
79Complement deficiency (HP:0004431)2.41578426
80Insomnia (HP:0100785)2.41188285
81Abnormality of glycine metabolism (HP:0010895)2.38963517
82Abnormality of serine family amino acid metabolism (HP:0010894)2.38963517
83Abnormality of vitamin B metabolism (HP:0004340)2.38099940
84Abnormality of glycolysis (HP:0004366)2.37522541
85Enlarged kidneys (HP:0000105)2.36810892
86Abnormality of the vasculature of the conjunctiva (HP:0008054)2.34734584
87Abnormality of iron homeostasis (HP:0011031)2.33729093
88Skin nodule (HP:0200036)2.32316359
89Mitral stenosis (HP:0001718)2.31806626
90Steatorrhea (HP:0002570)2.31466484
91Abnormal foot bone ossification (HP:0010675)2.31009709
92Hyperinsulinemic hypoglycemia (HP:0000825)2.30766892
93Ketosis (HP:0001946)2.30621002
94Abnormality of the wing of the ilium (HP:0011867)2.28566063
95Nausea (HP:0002018)2.28295490
96Epiphyseal dysplasia (HP:0002656)2.25163031
97Asymmetry of the thorax (HP:0001555)2.24374581
98Abnormality of the vitamin B12 metabolism (HP:0004341)2.19187120
99Hypochromic anemia (HP:0001931)2.16147571
100Irregular epiphyses (HP:0010582)2.13025467
101Hyperglycinuria (HP:0003108)2.12558284
102Hyperlipoproteinemia (HP:0010980)2.10936560
103Neonatal short-limb short stature (HP:0008921)2.08703425
104Abnormal delivery (HP:0001787)2.08167069
105Hypophosphatemic rickets (HP:0004912)2.07523106
106Epidermoid cyst (HP:0200040)2.06996750
107Hypertriglyceridemia (HP:0002155)2.06821088
108Abnormality of methionine metabolism (HP:0010901)2.05789500
109Neoplasm of the liver (HP:0002896)2.05536271
110Supernumerary spleens (HP:0009799)2.03841877
111Abnormality of vitamin metabolism (HP:0100508)2.02410524
112Macrocytic anemia (HP:0001972)2.01675574
113Increased serum ferritin (HP:0003281)1.99413516
114Premature rupture of membranes (HP:0001788)1.99324946
115Fat malabsorption (HP:0002630)1.98534699
116Decreased lacrimation (HP:0000633)1.98443301
117Abnormality of the alveolar ridges (HP:0006477)1.98356584
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92604623
119Absent epiphyses (HP:0010577)1.92604623
120Metabolic acidosis (HP:0001942)1.91821081
121Limited elbow extension (HP:0001377)1.91761178
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91209969
123Petechiae (HP:0000967)1.90841593
124Renal duplication (HP:0000075)1.90701612
125Cupped ribs (HP:0000887)1.89988265
126Glomerulonephritis (HP:0000099)1.88717985
127Abnormality of fatty-acid metabolism (HP:0004359)1.88108223
128Systemic lupus erythematosus (HP:0002725)1.86741538
129Protrusio acetabuli (HP:0003179)1.85984399
130Hyperglycinemia (HP:0002154)1.85833363
131Proximal tubulopathy (HP:0000114)1.85254641
132Chronic hepatic failure (HP:0100626)1.84466057
133Abnormal cartilage morphology (HP:0002763)1.83474770
134Papillary thyroid carcinoma (HP:0002895)1.83048080
135Nephrolithiasis (HP:0000787)1.82958480
136Symptomatic seizures (HP:0011145)1.82375085
137Abnormality of complement system (HP:0005339)1.82235452
138Joint swelling (HP:0001386)1.79614745
139Cerebral aneurysm (HP:0004944)1.79127091
140Malnutrition (HP:0004395)1.78772708
141Pulmonary embolism (HP:0002204)1.77632693
142Neonatal death (HP:0003811)1.75759221
143Abnormality of pain sensation (HP:0010832)1.73777991
144Impaired pain sensation (HP:0007328)1.73777991
145Childhood onset (HP:0011463)1.73357213
146Myocardial infarction (HP:0001658)1.65326799
147Wide nose (HP:0000445)1.64669401
148Ovoid vertebral bodies (HP:0003300)1.64597968
149Abnormality of pyrimidine metabolism (HP:0004353)1.64432827
150Beaking of vertebral bodies (HP:0004568)1.63753043
151Potter facies (HP:0002009)1.63298146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK25.20213356
2TIE14.86071693
3FGFR34.51192288
4PKN23.53329812
5TRIB33.30519119
6SCYL23.27070695
7KDR3.26889530
8FGFR22.91403067
9ICK2.82519832
10EIF2AK12.80082823
11PIK3CG2.77461841
12CDK122.58095152
13BCKDK2.53251005
14TYRO32.48197512
15AKT32.40381762
16MUSK2.39194877
17GRK62.32583967
18STK102.28858355
19PTK62.24583026
20TGFBR22.13538666
21RPS6KB21.92033568
22MAP3K111.91119197
23MAP2K31.86388540
24FLT31.74762105
25NME21.74758618
26ERN11.73993992
27MAPK111.73785883
28KSR21.71169939
29LRRK21.68873100
30NEK11.62736144
31MET1.62542470
32FGFR41.60808246
33LATS11.60588791
34MAP3K31.58355180
35PTK21.56968772
36PIK3CA1.56573254
37MAP3K81.55254421
38EEF2K1.45806824
39MAP3K101.43528240
40ACVR1B1.42553161
41PTK2B1.36184200
42MST41.35197203
43RIPK11.32877749
44MAP3K21.31286567
45WNK11.28745961
46AKT21.27495265
47DAPK21.27094824
48INSRR1.24523468
49EPHB11.18244903
50EPHB21.09638919
51PAK41.09511983
52NEK21.07790750
53MAP2K11.07521442
54MAP3K121.07337279
55TLK11.03596226
56TYK21.03417781
57MST1R1.03020870
58BRSK10.98044692
59PDGFRA0.93271035
60DYRK1B0.93236854
61LATS20.92185839
62SGK2230.91099405
63SGK4940.91099405
64SGK30.90810066
65NTRK30.89929594
66FGR0.86461515
67NEK90.86086925
68BUB10.85483893
69CDK70.84816157
70PAK30.83662078
71JAK20.81867447
72TTK0.80080937
73DDR20.79616584
74EPHA20.79359617
75PBK0.78236594
76CDC70.76786130
77MAPKAPK30.75403566
78BRD40.71709644
79RET0.71511816
80PRKG20.70489134
81RPS6KB10.70095501
82PRKCG0.69004019
83ERBB20.66393337
84FER0.65977647
85MAP3K10.65218925
86PRKAA10.64388264
87MAP4K10.63035342
88SGK20.61332184
89SIK20.61081643
90BRSK20.59890904
91STK390.59836914
92SMG10.59827445
93MAP2K20.59465559
94SIK10.59110069
95PRKACG0.58621496
96STK40.58307053
97TAOK10.57874541
98LMTK20.57357043
99PDPK10.56667002
100MAP2K40.56156145
101CDC42BPA0.55389501
102MAPK120.54457225
103CDK80.54202255
104NTRK10.53401893
105CDK60.53008557
106CASK0.52174976
107PDK10.52000189
108TAOK20.50830293
109FGFR10.50770311
110EPHA40.50753785
111SYK0.50651968
112MELK0.47926371
113CSNK2A20.47357190
114CDK90.44068251
115BMX0.43505093
116CDK40.42779730
117AURKA0.42656747
118TRPM70.42419379
119MAPKAPK50.42343359
120EIF2AK30.41990595
121TESK20.41594912
122MATK0.41018212
123PRKACB0.40468010
124LYN0.39303885
125PDGFRB0.38663220
126GRK10.38355252
127NEK60.37549645
128SRC0.37431773
129EGFR0.37177469
130NLK0.37026821
131PRKAA20.36666595
132CSNK2A10.36208639
133WNK40.36058610
134MAP2K60.35757554
135AURKB0.35352388
136CSK0.35327866
137KSR10.33251585
138ZAP700.33245565
139TTN0.33244205
140CSNK1E0.33082882
141CSNK1D0.31993186
142MTOR0.31342765
143GSK3A0.31239275
144SGK10.31207973
145ABL20.30287793
146PRKCZ0.30209896
147WNK30.28124117
148PRKCB0.27474386
149CAMK1D0.27262393
150BCR0.26312998
151TNIK0.26177591
152CSF1R0.22386382
153PRKG10.21229584
154CDK10.21066418
155ALK0.21042571

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.12303626
2Complement and coagulation cascades_Homo sapiens_hsa046104.21257094
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002603.43642415
4Vitamin B6 metabolism_Homo sapiens_hsa007503.12803619
5Vitamin digestion and absorption_Homo sapiens_hsa049773.03078176
6Arginine biosynthesis_Homo sapiens_hsa002203.00794682
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.95384275
8Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.93685817
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.85058802
10Fat digestion and absorption_Homo sapiens_hsa049752.72520641
11Fatty acid degradation_Homo sapiens_hsa000712.53118803
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.40351455
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24797407
14Staphylococcus aureus infection_Homo sapiens_hsa051502.00481630
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93448313
16Steroid biosynthesis_Homo sapiens_hsa001001.91906334
17Histidine metabolism_Homo sapiens_hsa003401.89753351
18Butanoate metabolism_Homo sapiens_hsa006501.89051516
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87039391
20Tryptophan metabolism_Homo sapiens_hsa003801.80539565
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.78982602
22Fatty acid metabolism_Homo sapiens_hsa012121.67912530
23PPAR signaling pathway_Homo sapiens_hsa033201.67579879
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60731390
25Arginine and proline metabolism_Homo sapiens_hsa003301.60628676
26Fatty acid biosynthesis_Homo sapiens_hsa000611.48477201
27Biosynthesis of amino acids_Homo sapiens_hsa012301.48092928
28Carbon metabolism_Homo sapiens_hsa012001.46841731
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44525093
30Pyruvate metabolism_Homo sapiens_hsa006201.44361960
31Fatty acid elongation_Homo sapiens_hsa000621.37698562
32beta-Alanine metabolism_Homo sapiens_hsa004101.37114495
33Selenocompound metabolism_Homo sapiens_hsa004501.30281980
34Propanoate metabolism_Homo sapiens_hsa006401.29747203
35Phenylalanine metabolism_Homo sapiens_hsa003601.25233315
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20806381
37One carbon pool by folate_Homo sapiens_hsa006701.17136872
38Sphingolipid metabolism_Homo sapiens_hsa006001.17048104
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.15600016
40Sulfur relay system_Homo sapiens_hsa041221.06398747
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.05126439
42Galactose metabolism_Homo sapiens_hsa000521.03614897
43Systemic lupus erythematosus_Homo sapiens_hsa053221.01737214
44Pentose phosphate pathway_Homo sapiens_hsa000301.00358935
45Peroxisome_Homo sapiens_hsa041460.99974744
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.98144600
47ABC transporters_Homo sapiens_hsa020100.93131478
48Sulfur metabolism_Homo sapiens_hsa009200.92842376
49Lysine degradation_Homo sapiens_hsa003100.92393769
50Retinol metabolism_Homo sapiens_hsa008300.91548917
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89519861
52Bile secretion_Homo sapiens_hsa049760.85534441
53Tyrosine metabolism_Homo sapiens_hsa003500.85055883
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85027913
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.79000901
56ECM-receptor interaction_Homo sapiens_hsa045120.75308891
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72097977
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71627376
59Glycerolipid metabolism_Homo sapiens_hsa005610.69581740
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68610854
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67979800
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62579967
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.60718376
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60209494
65Glutathione metabolism_Homo sapiens_hsa004800.58976616
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56944981
67Starch and sucrose metabolism_Homo sapiens_hsa005000.56708420
68Caffeine metabolism_Homo sapiens_hsa002320.56267110
69Folate biosynthesis_Homo sapiens_hsa007900.55224652
70Ether lipid metabolism_Homo sapiens_hsa005650.54346334
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50186718
72Chemical carcinogenesis_Homo sapiens_hsa052040.47112367
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46622864
74Other glycan degradation_Homo sapiens_hsa005110.46092457
75Fructose and mannose metabolism_Homo sapiens_hsa000510.42495374
76Protein digestion and absorption_Homo sapiens_hsa049740.42465150
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36279817
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35328797
79Insulin resistance_Homo sapiens_hsa049310.33675945
80Metabolic pathways_Homo sapiens_hsa011000.30980538
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30597633
82Platelet activation_Homo sapiens_hsa046110.30059592
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28915457
84Small cell lung cancer_Homo sapiens_hsa052220.27758763
85Alcoholism_Homo sapiens_hsa050340.27034126
86Mineral absorption_Homo sapiens_hsa049780.26508822
87African trypanosomiasis_Homo sapiens_hsa051430.25812203
88Bladder cancer_Homo sapiens_hsa052190.25353444
89Prion diseases_Homo sapiens_hsa050200.18367039
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18291101
91Thyroid cancer_Homo sapiens_hsa052160.18106280
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.15469332
93Linoleic acid metabolism_Homo sapiens_hsa005910.14608889
94Lysosome_Homo sapiens_hsa041420.14290179
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13761541
96Amoebiasis_Homo sapiens_hsa051460.13674663
97Focal adhesion_Homo sapiens_hsa045100.11484256
98DNA replication_Homo sapiens_hsa030300.10512965
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10083801
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.09304375
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.09217840
102Glucagon signaling pathway_Homo sapiens_hsa049220.07390011
103Thyroid hormone synthesis_Homo sapiens_hsa049180.07034392
104Adherens junction_Homo sapiens_hsa045200.06876399
105Arachidonic acid metabolism_Homo sapiens_hsa005900.06362295
106Renin-angiotensin system_Homo sapiens_hsa046140.06274231
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.06169727
108HIF-1 signaling pathway_Homo sapiens_hsa040660.06167093
109Inositol phosphate metabolism_Homo sapiens_hsa005620.04230316
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.03960923
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.02767618
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.02233217
113Viral carcinogenesis_Homo sapiens_hsa052030.01889652
114Collecting duct acid secretion_Homo sapiens_hsa049660.01640299
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.01129475
116AMPK signaling pathway_Homo sapiens_hsa041520.01042204
117Proteoglycans in cancer_Homo sapiens_hsa05205-0.0160187
118N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0127489

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