Rank | Gene Set | Z-score |
---|---|---|
1 | COPI coating of Golgi vesicle (GO:0048205) | 8.71101963 |
2 | Golgi transport vesicle coating (GO:0048200) | 8.71101963 |
3 | signal peptide processing (GO:0006465) | 8.70178089 |
4 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 6.98651959 |
5 | protein retention in ER lumen (GO:0006621) | 6.35049025 |
6 | COPII vesicle coating (GO:0048208) | 5.69623140 |
7 | protein maturation by protein folding (GO:0022417) | 5.10437566 |
8 | sequestering of metal ion (GO:0051238) | 5.06023244 |
9 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 4.85369524 |
10 | endocrine pancreas development (GO:0031018) | 4.70097768 |
11 | ER overload response (GO:0006983) | 4.69403444 |
12 | peptide hormone processing (GO:0016486) | 4.43766296 |
13 | regulation of type B pancreatic cell apoptotic process (GO:2000674) | 4.40015382 |
14 | proteasome assembly (GO:0043248) | 4.30682576 |
15 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235 | 3.86535508 |
16 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 3.85446648 |
17 | nucleotide transmembrane transport (GO:1901679) | 3.84414665 |
18 | exocrine pancreas development (GO:0031017) | 3.72756885 |
19 | protein N-linked glycosylation via asparagine (GO:0018279) | 3.70300394 |
20 | positive regulation of nuclease activity (GO:0032075) | 3.68310226 |
21 | GDP-mannose metabolic process (GO:0019673) | 3.65963114 |
22 | ER-associated ubiquitin-dependent protein catabolic process (GO:0030433) | 3.64875568 |
23 | peptidyl-asparagine modification (GO:0018196) | 3.63474730 |
24 | cellular response to unfolded protein (GO:0034620) | 3.55375536 |
25 | ER to Golgi vesicle-mediated transport (GO:0006888) | 3.55364429 |
26 | endoplasmic reticulum unfolded protein response (GO:0030968) | 3.53936825 |
27 | cellular response to vitamin D (GO:0071305) | 3.50484572 |
28 | cellular response to topologically incorrect protein (GO:0035967) | 3.47463777 |
29 | protein N-linked glycosylation (GO:0006487) | 3.43672036 |
30 | regulation of nuclease activity (GO:0032069) | 3.43176164 |
31 | glandular epithelial cell differentiation (GO:0002067) | 3.31374674 |
32 | vesicle coating (GO:0006901) | 3.28670661 |
33 | negative regulation of glycoprotein biosynthetic process (GO:0010561) | 3.25219859 |
34 | ER-nucleus signaling pathway (GO:0006984) | 3.24966390 |
35 | fucose metabolic process (GO:0006004) | 3.23682114 |
36 | regulation of ER to Golgi vesicle-mediated transport (GO:0060628) | 3.21665148 |
37 | synapsis (GO:0007129) | 3.19927394 |
38 | positive regulation of insulin secretion (GO:0032024) | 3.19505611 |
39 | nucleotide-sugar biosynthetic process (GO:0009226) | 3.16678992 |
40 | keratan sulfate catabolic process (GO:0042340) | 3.13225821 |
41 | protein deneddylation (GO:0000338) | 3.07438709 |
42 | cullin deneddylation (GO:0010388) | 3.06634328 |
43 | peptide catabolic process (GO:0043171) | 3.03145529 |
44 | toxin metabolic process (GO:0009404) | 3.01921921 |
45 | response to endoplasmic reticulum stress (GO:0034976) | 3.01921005 |
46 | regulation of metalloenzyme activity (GO:0048552) | 3.01666803 |
47 | negative regulation of glycoprotein metabolic process (GO:1903019) | 3.00545613 |
48 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.97695944 |
49 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.95836723 |
50 | mannosylation (GO:0097502) | 2.95702873 |
51 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.95317180 |
52 | cellular response to vitamin (GO:0071295) | 2.94519941 |
53 | piRNA metabolic process (GO:0034587) | 2.92905935 |
54 | peptide metabolic process (GO:0006518) | 2.92160009 |
55 | glycoside metabolic process (GO:0016137) | 2.90434686 |
56 | regulation of meiosis I (GO:0060631) | 2.89384194 |
57 | neutrophil activation involved in immune response (GO:0002283) | 2.88246940 |
58 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.87502659 |
59 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 2.86892342 |
60 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.86094649 |
61 | cellular ketone body metabolic process (GO:0046950) | 2.85438771 |
62 | platelet dense granule organization (GO:0060155) | 2.85321981 |
63 | C-terminal protein lipidation (GO:0006501) | 2.84982689 |
64 | amyloid precursor protein catabolic process (GO:0042987) | 2.84024420 |
65 | purine nucleotide salvage (GO:0032261) | 2.83752098 |
66 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.80825220 |
67 | nucleoside diphosphate catabolic process (GO:0009134) | 2.80371203 |
68 | glucosamine-containing compound catabolic process (GO:1901072) | 2.78435021 |
69 | type B pancreatic cell development (GO:0003323) | 2.78200351 |
70 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.76567547 |
71 | virion attachment to host cell (GO:0019062) | 2.75770833 |
72 | adhesion of symbiont to host cell (GO:0044650) | 2.75770833 |
73 | ketone body metabolic process (GO:1902224) | 2.75545419 |
74 | purine-containing compound salvage (GO:0043101) | 2.75463060 |
75 | response to unfolded protein (GO:0006986) | 2.75297409 |
76 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.74688721 |
77 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.73024240 |
78 | response to topologically incorrect protein (GO:0035966) | 2.71622223 |
79 | eosinophil chemotaxis (GO:0048245) | 2.67930224 |
80 | regulation of DNA endoreduplication (GO:0032875) | 2.66566862 |
81 | regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714) | 2.66460006 |
82 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 2.65512714 |
83 | nucleotide-sugar metabolic process (GO:0009225) | 2.65499270 |
84 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.64211613 |
85 | negative regulation of ligase activity (GO:0051352) | 2.64211613 |
86 | DNA ligation (GO:0006266) | 2.64067454 |
87 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.62511038 |
88 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.62511038 |
89 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.62511038 |
90 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.62432075 |
91 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.62432075 |
92 | cell redox homeostasis (GO:0045454) | 2.61814840 |
93 | cellular zinc ion homeostasis (GO:0006882) | 2.59045292 |
94 | glandular epithelial cell development (GO:0002068) | 2.54413994 |
95 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.54044872 |
96 | cellular response to ATP (GO:0071318) | 2.53993183 |
97 | positive regulation of peptide hormone secretion (GO:0090277) | 2.53572878 |
98 | negative regulation of JUN kinase activity (GO:0043508) | 2.53395394 |
99 | protein autoprocessing (GO:0016540) | 2.53346172 |
100 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.53324784 |
101 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.52983343 |
102 | glycolipid catabolic process (GO:0019377) | 2.52722683 |
103 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 2.52248256 |
104 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 2.52248256 |
105 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 2.51393509 |
106 | L-phenylalanine metabolic process (GO:0006558) | 2.51393509 |
107 | polyketide metabolic process (GO:0030638) | 2.48023300 |
108 | doxorubicin metabolic process (GO:0044598) | 2.48023300 |
109 | daunorubicin metabolic process (GO:0044597) | 2.48023300 |
110 | cellular response to hepatocyte growth factor stimulus (GO:0035729) | 2.47891340 |
111 | response to hepatocyte growth factor (GO:0035728) | 2.47891340 |
112 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.47723086 |
113 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.47723086 |
114 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 2.45855528 |
115 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 2.45855528 |
116 | glycosphingolipid catabolic process (GO:0046479) | 2.45655681 |
117 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.45623684 |
118 | positive regulation of ligase activity (GO:0051351) | 2.44867133 |
119 | response to redox state (GO:0051775) | 2.44698677 |
120 | negative regulation of norepinephrine secretion (GO:0010700) | 2.44305660 |
121 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.44157373 |
122 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.43960341 |
123 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.43960341 |
124 | isotype switching (GO:0045190) | 2.43960341 |
125 | response to hydroperoxide (GO:0033194) | 2.43054802 |
126 | ribosome assembly (GO:0042255) | 2.42488752 |
127 | GPI anchor biosynthetic process (GO:0006506) | 2.42379261 |
128 | cellular response to antibiotic (GO:0071236) | 2.41832421 |
129 | intra-Golgi vesicle-mediated transport (GO:0006891) | 2.41620700 |
130 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.39980507 |
131 | interleukin-1-mediated signaling pathway (GO:0070498) | 2.39874836 |
132 | negative regulation of bone resorption (GO:0045779) | 2.38831208 |
133 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 2.38466303 |
134 | regulation of growth of symbiont in host (GO:0044126) | 2.38466303 |
135 | negative regulation of growth of symbiont in host (GO:0044130) | 2.38466303 |
136 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 2.38466303 |
137 | regulation of glucokinase activity (GO:0033131) | 2.38231870 |
138 | regulation of hexokinase activity (GO:1903299) | 2.38231870 |
139 | L-phenylalanine catabolic process (GO:0006559) | 2.38106789 |
140 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 2.38106789 |
141 | regulation of integrin-mediated signaling pathway (GO:2001044) | 2.37321203 |
142 | magnesium ion transport (GO:0015693) | 2.37167447 |
143 | positive regulation of peptide secretion (GO:0002793) | 2.36712878 |
144 | organelle membrane fusion (GO:0090174) | 2.36522630 |
145 | 4-hydroxyproline metabolic process (GO:0019471) | 2.36001327 |
146 | nucleotide transport (GO:0006862) | 2.35968609 |
147 | ceramide catabolic process (GO:0046514) | 2.35966363 |
148 | protein neddylation (GO:0045116) | 2.35274622 |
149 | protein complex biogenesis (GO:0070271) | 2.34678509 |
150 | positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357 | 2.34159960 |
151 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.34152259 |
152 | ATP synthesis coupled proton transport (GO:0015986) | 2.33793814 |
153 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.33793814 |
154 | regulation of insulin secretion (GO:0050796) | 2.33178044 |
155 | nucleoside salvage (GO:0043174) | 2.32707510 |
156 | S-adenosylmethionine metabolic process (GO:0046500) | 2.31648076 |
157 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.31613066 |
158 | eosinophil migration (GO:0072677) | 2.31251850 |
159 | adenosine metabolic process (GO:0046085) | 2.31183530 |
160 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.30381070 |
161 | proline biosynthetic process (GO:0006561) | 2.30334949 |
162 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 2.30083578 |
163 | regulation of regulatory T cell differentiation (GO:0045589) | 2.29947368 |
164 | oligosaccharide catabolic process (GO:0009313) | 2.29828015 |
165 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.29496737 |
166 | cytochrome complex assembly (GO:0017004) | 2.28164170 |
167 | keratinocyte development (GO:0003334) | 2.27740275 |
168 | C-terminal protein amino acid modification (GO:0018410) | 2.26565250 |
169 | sphingosine metabolic process (GO:0006670) | 2.26187376 |
170 | regulation of B cell apoptotic process (GO:0002902) | 2.25220711 |
171 | transcytosis (GO:0045056) | 2.23156232 |
172 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.19231791 |
173 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.19231791 |
174 | heme metabolic process (GO:0042168) | 2.18441862 |
175 | B cell activation involved in immune response (GO:0002312) | 2.18296100 |
176 | type B pancreatic cell proliferation (GO:0044342) | 2.16851746 |
177 | sphingoid metabolic process (GO:0046519) | 2.16149612 |
178 | negative regulation of complement activation (GO:0045916) | 2.14829163 |
179 | heme biosynthetic process (GO:0006783) | 2.14231379 |
180 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.13609497 |
181 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.13418935 |
182 | respiratory chain complex IV assembly (GO:0008535) | 2.10088848 |
Rank | Gene Set | Z-score |
---|---|---|
1 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 5.57410967 |
2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.19479663 |
3 | GATA1_22025678_ChIP-Seq_K562_Human | 3.42984590 |
4 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 3.41539966 |
5 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 3.36172924 |
6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.11466695 |
7 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.76596936 |
8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.62041735 |
9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.48450664 |
10 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.45178861 |
11 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.38034571 |
12 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 2.36847531 |
13 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.19474103 |
14 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.16832378 |
15 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 2.06003314 |
16 | TFEB_21752829_ChIP-Seq_HELA_Human | 2.05187392 |
17 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.03715335 |
18 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.94946020 |
19 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.91458397 |
20 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.91070355 |
21 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.87135358 |
22 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.87025682 |
23 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.79508940 |
24 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.72129622 |
25 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.70944234 |
26 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.69798827 |
27 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.69282175 |
28 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.67505587 |
29 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.63749434 |
30 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.61125865 |
31 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.61018032 |
32 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.60854683 |
33 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.60056984 |
34 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.59784777 |
35 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.58082921 |
36 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.57875145 |
37 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.53694565 |
38 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.53070779 |
39 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.51903311 |
40 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.51724355 |
41 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.51594644 |
42 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.51311630 |
43 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.48385781 |
44 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.46567047 |
45 | * NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.46334016 |
46 | * NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.46334016 |
47 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.45084827 |
48 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.43241082 |
49 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.41997851 |
50 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.40551435 |
51 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.39654697 |
52 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.39533259 |
53 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38999039 |
54 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.37138419 |
55 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.35333473 |
56 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.32968525 |
57 | MYB_26560356_Chip-Seq_TH2_Human | 1.32551739 |
58 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.32301825 |
59 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.31889368 |
60 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31462222 |
61 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.31177608 |
62 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.30227105 |
63 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.28287967 |
64 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.28152708 |
65 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.27763135 |
66 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.27477580 |
67 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.26908709 |
68 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.25311619 |
69 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.24447844 |
70 | * Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.22667576 |
71 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.21134605 |
72 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.21014561 |
73 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.20704994 |
74 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.19729231 |
75 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.18926094 |
76 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.17998497 |
77 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.17817275 |
78 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.17797815 |
79 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.17141169 |
80 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16489665 |
81 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.16054522 |
82 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.14156227 |
83 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.13995255 |
84 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.13740174 |
85 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.13541786 |
86 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.13098462 |
87 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.11940120 |
88 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.11664142 |
89 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.11161975 |
90 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.09315053 |
91 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.09150410 |
92 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.09053695 |
93 | * AR_20517297_ChIP-Seq_VCAP_Human | 1.08774995 |
94 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.08321918 |
95 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.07862888 |
96 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.07542519 |
97 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.07159303 |
98 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.06610999 |
99 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.06430584 |
100 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.06183689 |
101 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.05745953 |
102 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.05610749 |
103 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.05421784 |
104 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.05190833 |
105 | GATA3_26560356_Chip-Seq_TH2_Human | 1.02984443 |
106 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.02637390 |
107 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.02501328 |
108 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.01855900 |
109 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.01523527 |
110 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.01439531 |
111 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.01160127 |
112 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.00714592 |
113 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.99787392 |
114 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.98844229 |
115 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.98446080 |
116 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.98372745 |
117 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.98234408 |
118 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.98213608 |
119 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.97482909 |
120 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.97353362 |
121 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.97226093 |
122 | CJUN_26792858_Chip-Seq_BT549_Human | 0.97174643 |
123 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.96832239 |
124 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.95666269 |
125 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.94610006 |
126 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.94606694 |
127 | FUS_26573619_Chip-Seq_HEK293_Human | 0.94308319 |
128 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.93776875 |
129 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.93387293 |
130 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.93047920 |
131 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 0.92727267 |
132 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.91991748 |
133 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.91836281 |
134 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.91780769 |
135 | * RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.91165866 |
136 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.89297532 |
137 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.88402424 |
138 | MYB_26560356_Chip-Seq_TH1_Human | 0.87927684 |
139 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.87733009 |
140 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.85871566 |
141 | EWS_26573619_Chip-Seq_HEK293_Human | 0.85668468 |
142 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.83538533 |
143 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.83002187 |
144 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.82011637 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0000013_abnormal_adipose_tissue | 4.07835335 |
2 | MP0008438_abnormal_cutaneous_collagen | 3.85348964 |
3 | MP0002877_abnormal_melanocyte_morpholog | 3.69388374 |
4 | MP0003195_calcinosis | 3.56669270 |
5 | MP0003183_abnormal_peptide_metabolism | 3.28796983 |
6 | MP0004043_abnormal_pH_regulation | 2.96071731 |
7 | MP0005220_abnormal_exocrine_pancreas | 2.85532181 |
8 | MP0005379_endocrine/exocrine_gland_phen | 2.77863541 |
9 | MP0006054_spinal_hemorrhage | 2.77826113 |
10 | MP0002693_abnormal_pancreas_physiology | 2.72489812 |
11 | * MP0005058_abnormal_lysosome_morphology | 2.48661468 |
12 | MP0001944_abnormal_pancreas_morphology | 2.40651780 |
13 | MP0003191_abnormal_cellular_cholesterol | 2.34821435 |
14 | MP0003950_abnormal_plasma_membrane | 2.26035446 |
15 | MP0003283_abnormal_digestive_organ | 2.16662821 |
16 | MP0008007_abnormal_cellular_replicative | 2.07137360 |
17 | MP0005503_abnormal_tendon_morphology | 2.01039494 |
18 | MP0000003_abnormal_adipose_tissue | 1.97695423 |
19 | MP0003279_aneurysm | 1.95343052 |
20 | MP0003172_abnormal_lysosome_physiology | 1.94128791 |
21 | MP0001853_heart_inflammation | 1.87546340 |
22 | MP0005075_abnormal_melanosome_morpholog | 1.85425940 |
23 | MP0009840_abnormal_foam_cell | 1.80137811 |
24 | MP0003806_abnormal_nucleotide_metabolis | 1.79824366 |
25 | MP0003656_abnormal_erythrocyte_physiolo | 1.74219207 |
26 | MP0003724_increased_susceptibility_to | 1.72630116 |
27 | MP0002837_dystrophic_cardiac_calcinosis | 1.70339580 |
28 | MP0002166_altered_tumor_susceptibility | 1.67967384 |
29 | MP0003186_abnormal_redox_activity | 1.66909382 |
30 | MP0005084_abnormal_gallbladder_morpholo | 1.66516613 |
31 | MP0005275_abnormal_skin_tensile | 1.65171747 |
32 | MP0002909_abnormal_adrenal_gland | 1.65072873 |
33 | MP0009384_cardiac_valve_regurgitation | 1.59769859 |
34 | MP0005645_abnormal_hypothalamus_physiol | 1.59566577 |
35 | MP0009780_abnormal_chondrocyte_physiolo | 1.55052310 |
36 | MP0008058_abnormal_DNA_repair | 1.49642563 |
37 | MP0003786_premature_aging | 1.47649463 |
38 | MP0002933_joint_inflammation | 1.47505932 |
39 | MP0003011_delayed_dark_adaptation | 1.47439093 |
40 | MP0000678_abnormal_parathyroid_gland | 1.47373598 |
41 | MP0004147_increased_porphyrin_level | 1.44510682 |
42 | MP0002006_tumorigenesis | 1.43094232 |
43 | MP0006036_abnormal_mitochondrial_physio | 1.42633727 |
44 | MP0002295_abnormal_pulmonary_circulatio | 1.40656542 |
45 | MP0005408_hypopigmentation | 1.39388334 |
46 | MP0002078_abnormal_glucose_homeostasis | 1.39225244 |
47 | MP0005365_abnormal_bile_salt | 1.38986347 |
48 | * MP0009643_abnormal_urine_homeostasis | 1.38678505 |
49 | MP0002452_abnormal_antigen_presenting | 1.37474789 |
50 | MP0001533_abnormal_skeleton_physiology | 1.37204093 |
51 | * MP0010386_abnormal_urinary_bladder | 1.35503456 |
52 | MP0002138_abnormal_hepatobiliary_system | 1.34609689 |
53 | MP0001958_emphysema | 1.34331847 |
54 | MP0008877_abnormal_DNA_methylation | 1.34177540 |
55 | MP0005025_abnormal_response_to | 1.34032347 |
56 | MP0002896_abnormal_bone_mineralization | 1.33927770 |
57 | MP0002928_abnormal_bile_duct | 1.28774205 |
58 | MP0010094_abnormal_chromosome_stability | 1.27643100 |
59 | MP0000465_gastrointestinal_hemorrhage | 1.27298949 |
60 | MP0003795_abnormal_bone_structure | 1.27277981 |
61 | MP0002723_abnormal_immune_serum | 1.26591414 |
62 | MP0003959_abnormal_lean_body | 1.25412097 |
63 | MP0002163_abnormal_gland_morphology | 1.25086156 |
64 | MP0003252_abnormal_bile_duct | 1.24120852 |
65 | MP0006082_CNS_inflammation | 1.23939667 |
66 | MP0001986_abnormal_taste_sensitivity | 1.23934432 |
67 | MP0008875_abnormal_xenobiotic_pharmacok | 1.23827264 |
68 | MP0001542_abnormal_bone_strength | 1.22715990 |
69 | MP0001800_abnormal_humoral_immune | 1.21150798 |
70 | MP0008057_abnormal_DNA_replication | 1.20586779 |
71 | MP0002405_respiratory_system_inflammati | 1.18984130 |
72 | MP0002148_abnormal_hypersensitivity_rea | 1.18810373 |
73 | MP0000613_abnormal_salivary_gland | 1.18303761 |
74 | MP0001835_abnormal_antigen_presentation | 1.18155544 |
75 | MP0009697_abnormal_copulation | 1.18031743 |
76 | MP0005464_abnormal_platelet_physiology | 1.17482404 |
77 | MP0000604_amyloidosis | 1.15116477 |
78 | MP0002139_abnormal_hepatobiliary_system | 1.14830519 |
79 | MP0002420_abnormal_adaptive_immunity | 1.13536682 |
80 | MP0005171_absent_coat_pigmentation | 1.12998645 |
81 | MP0001819_abnormal_immune_cell | 1.11941678 |
82 | MP0003300_gastrointestinal_ulcer | 1.10314031 |
83 | MP0003436_decreased_susceptibility_to | 1.10197318 |
84 | MP0005390_skeleton_phenotype | 1.09849998 |
85 | MP0010234_abnormal_vibrissa_follicle | 1.09330204 |
86 | MP0004272_abnormal_basement_membrane | 1.07703713 |
87 | MP0000015_abnormal_ear_pigmentation | 1.06357723 |
88 | MP0001666_abnormal_nutrient_absorption | 1.06350032 |
89 | MP0005257_abnormal_intraocular_pressure | 1.06053867 |
90 | MP0005508_abnormal_skeleton_morphology | 1.05921965 |
91 | MP0000371_diluted_coat_color | 1.05038392 |
92 | MP0002998_abnormal_bone_remodeling | 1.04927042 |
93 | MP0002060_abnormal_skin_morphology | 1.01438956 |
94 | MP0010352_gastrointestinal_tract_polyps | 1.00747904 |
95 | MP0002419_abnormal_innate_immunity | 0.99976905 |
96 | MP0000372_irregular_coat_pigmentation | 0.99283239 |
97 | MP0002090_abnormal_vision | 0.98353207 |
98 | MP0001243_abnormal_dermal_layer | 0.98036920 |
99 | MP0001756_abnormal_urination | 0.97830639 |
100 | MP0000689_abnormal_spleen_morphology | 0.95425499 |
101 | MP0005000_abnormal_immune_tolerance | 0.95193541 |
102 | MP0005671_abnormal_response_to | 0.95136375 |
103 | MP0003075_altered_response_to | 0.95069241 |
104 | MP0005319_abnormal_enzyme/_coenzyme | 0.94140469 |
105 | MP0009785_altered_susceptibility_to | 0.92929724 |
106 | MP0000163_abnormal_cartilage_morphology | 0.92329194 |
107 | MP0006072_abnormal_retinal_apoptosis | 0.92311591 |
108 | MP0005636_abnormal_mineral_homeostasis | 0.91876841 |
109 | MP0004264_abnormal_extraembryonic_tissu | 0.91611089 |
110 | MP0000681_abnormal_thyroid_gland | 0.91294458 |
111 | MP0002396_abnormal_hematopoietic_system | 0.90412248 |
112 | MP0005174_abnormal_tail_pigmentation | 0.90276587 |
113 | MP0001764_abnormal_homeostasis | 0.89406298 |
114 | MP0000358_abnormal_cell_content/ | 0.88678969 |
115 | MP0002254_reproductive_system_inflammat | 0.88478832 |
116 | MP0008260_abnormal_autophagy | 0.88410073 |
117 | MP0009764_decreased_sensitivity_to | 0.88388719 |
118 | MP0003303_peritoneal_inflammation | 0.87897523 |
119 | MP0005165_increased_susceptibility_to | 0.86429185 |
120 | MP0009763_increased_sensitivity_to | 0.86235853 |
121 | MP0000858_altered_metastatic_potential | 0.86179950 |
122 | MP0001790_abnormal_immune_system | 0.86022354 |
123 | MP0005387_immune_system_phenotype | 0.86022354 |
124 | MP0004947_skin_inflammation | 0.85992928 |
125 | MP0005646_abnormal_pituitary_gland | 0.85237916 |
126 | MP0001299_abnormal_eye_distance/ | 0.85040837 |
127 | MP0004782_abnormal_surfactant_physiolog | 0.84999373 |
128 | MP0010329_abnormal_lipoprotein_level | 0.84282120 |
129 | MP0000685_abnormal_immune_system | 0.84176779 |
130 | MP0003763_abnormal_thymus_physiology | 0.83604001 |
131 | MP0000343_altered_response_to | 0.83578598 |
132 | MP0002938_white_spotting | 0.81984330 |
133 | MP0005375_adipose_tissue_phenotype | 0.81383931 |
134 | MP0000609_abnormal_liver_physiology | 0.81216372 |
135 | MP0008469_abnormal_protein_level | 0.81165114 |
136 | MP0000716_abnormal_immune_system | 0.79607856 |
137 | MP0001765_abnormal_ion_homeostasis | 0.78817776 |
138 | MP0001845_abnormal_inflammatory_respons | 0.78343009 |
139 | MP0005332_abnormal_amino_acid | 0.76414162 |
140 | MP0005164_abnormal_response_to | 0.74915086 |
141 | MP0000230_abnormal_systemic_arterial | 0.74049954 |
142 | MP0005023_abnormal_wound_healing | 0.73327468 |
143 | MP0001661_extended_life_span | 0.72027346 |
144 | MP0000920_abnormal_myelination | 0.71955719 |
145 | MP0002876_abnormal_thyroid_physiology | 0.71798700 |
146 | MP0000639_abnormal_adrenal_gland | 0.71677386 |
147 | MP0002638_abnormal_pupillary_reflex | 0.70861324 |
148 | MP0003868_abnormal_feces_composition | 0.70639850 |
149 | MP0002168_other_aberrant_phenotype | 0.69478977 |
150 | MP0003953_abnormal_hormone_level | 0.69460941 |
151 | MP0001348_abnormal_lacrimal_gland | 0.68837014 |
152 | MP0009333_abnormal_splenocyte_physiolog | 0.68086628 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Hypoglycemic coma (HP:0001325) | 5.39710045 |
2 | Hypoglycemic seizures (HP:0002173) | 5.10098876 |
3 | Hyperinsulinemic hypoglycemia (HP:0000825) | 4.95833064 |
4 | Symptomatic seizures (HP:0011145) | 4.71071849 |
5 | Generalized aminoaciduria (HP:0002909) | 4.01440844 |
6 | Abnormality of the intrinsic pathway (HP:0010989) | 3.81583388 |
7 | Urinary glycosaminoglycan excretion (HP:0003541) | 3.81134959 |
8 | Mucopolysacchariduria (HP:0008155) | 3.81134959 |
9 | * Dysostosis multiplex (HP:0000943) | 3.80217735 |
10 | Abnormal protein glycosylation (HP:0012346) | 3.44342849 |
11 | Abnormal glycosylation (HP:0012345) | 3.44342849 |
12 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 3.44342849 |
13 | Abnormal protein N-linked glycosylation (HP:0012347) | 3.44342849 |
14 | Abnormality of polysaccharide metabolism (HP:0011012) | 3.41998368 |
15 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 3.41998368 |
16 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 3.41998368 |
17 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 3.37921281 |
18 | Type I transferrin isoform profile (HP:0003642) | 3.36413047 |
19 | Loss of speech (HP:0002371) | 3.22556811 |
20 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 3.13838480 |
21 | Cervical subluxation (HP:0003308) | 3.12115540 |
22 | Ketoacidosis (HP:0001993) | 3.08936118 |
23 | Vertebral compression fractures (HP:0002953) | 3.00790208 |
24 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.99955101 |
25 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.99955101 |
26 | Abnormality of glycolipid metabolism (HP:0010969) | 2.99955101 |
27 | Hyperglycemia (HP:0003074) | 2.98936814 |
28 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.97528427 |
29 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.95138811 |
30 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.95138811 |
31 | Large for gestational age (HP:0001520) | 2.90345886 |
32 | Late onset (HP:0003584) | 2.88409236 |
33 | Progressive neurologic deterioration (HP:0002344) | 2.87130370 |
34 | Metaphyseal dysplasia (HP:0100255) | 2.84819679 |
35 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.77106401 |
36 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.75223295 |
37 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.62102985 |
38 | Mitochondrial inheritance (HP:0001427) | 2.59611146 |
39 | Premature rupture of membranes (HP:0001788) | 2.55593135 |
40 | Abnormality of macrophages (HP:0004311) | 2.54933012 |
41 | Progressive macrocephaly (HP:0004481) | 2.53703594 |
42 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 2.53693580 |
43 | Hypothermia (HP:0002045) | 2.53325035 |
44 | 3-Methylglutaconic aciduria (HP:0003535) | 2.51671063 |
45 | Hepatocellular necrosis (HP:0001404) | 2.49472926 |
46 | Stomatitis (HP:0010280) | 2.49162632 |
47 | Increased CSF lactate (HP:0002490) | 2.48701921 |
48 | Acute necrotizing encephalopathy (HP:0006965) | 2.48461350 |
49 | * Vacuolated lymphocytes (HP:0001922) | 2.48413426 |
50 | Agnosia (HP:0010524) | 2.46977116 |
51 | Abnormality of the common coagulation pathway (HP:0010990) | 2.43475349 |
52 | Retinal atrophy (HP:0001105) | 2.42140264 |
53 | Prolonged neonatal jaundice (HP:0006579) | 2.40823790 |
54 | Conjunctival hamartoma (HP:0100780) | 2.39949547 |
55 | Increased serum pyruvate (HP:0003542) | 2.36251487 |
56 | Increased cerebral lipofuscin (HP:0011813) | 2.35804137 |
57 | Vascular calcification (HP:0004934) | 2.35290499 |
58 | Flat capital femoral epiphysis (HP:0003370) | 2.34065567 |
59 | Congenital, generalized hypertrichosis (HP:0004540) | 2.31550313 |
60 | Joint stiffness (HP:0001387) | 2.30601393 |
61 | Lipid accumulation in hepatocytes (HP:0006561) | 2.30470428 |
62 | Reduced antithrombin III activity (HP:0001976) | 2.29531577 |
63 | Follicular hyperkeratosis (HP:0007502) | 2.28407924 |
64 | * Beaking of vertebral bodies (HP:0004568) | 2.28263695 |
65 | Renal Fanconi syndrome (HP:0001994) | 2.26484985 |
66 | Steatorrhea (HP:0002570) | 2.26114469 |
67 | Abnormal pancreas size (HP:0012094) | 2.26072010 |
68 | Hypokinesia (HP:0002375) | 2.26032297 |
69 | Sparse eyelashes (HP:0000653) | 2.24954069 |
70 | Disinhibition (HP:0000734) | 2.23778493 |
71 | Glycosuria (HP:0003076) | 2.23046404 |
72 | Abnormality of urine glucose concentration (HP:0011016) | 2.23046404 |
73 | Cardiovascular calcification (HP:0011915) | 2.21538441 |
74 | Protrusio acetabuli (HP:0003179) | 2.20589569 |
75 | Irregular vertebral endplates (HP:0003301) | 2.18562576 |
76 | Hyperparathyroidism (HP:0000843) | 2.16526708 |
77 | Thoracolumbar scoliosis (HP:0002944) | 2.16517102 |
78 | Flared iliac wings (HP:0002869) | 2.14877835 |
79 | Hepatosplenomegaly (HP:0001433) | 2.14425919 |
80 | Increased hepatocellular lipid droplets (HP:0006565) | 2.12827067 |
81 | Exocrine pancreatic insufficiency (HP:0001738) | 2.12451176 |
82 | Abnormal tarsal ossification (HP:0008369) | 2.11716325 |
83 | Acute encephalopathy (HP:0006846) | 2.11646646 |
84 | Renal cortical cysts (HP:0000803) | 2.11468754 |
85 | Respiratory failure (HP:0002878) | 2.11307424 |
86 | Exertional dyspnea (HP:0002875) | 2.08596808 |
87 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.08575173 |
88 | Hypokalemia (HP:0002900) | 2.08137427 |
89 | Abnormality of glycolysis (HP:0004366) | 2.07081215 |
90 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.06626621 |
91 | Spastic paraparesis (HP:0002313) | 2.06261685 |
92 | Abnormality of the prostate (HP:0008775) | 2.00733483 |
93 | Wormian bones (HP:0002645) | 2.00499811 |
94 | Abnormal foot bone ossification (HP:0010675) | 1.99891428 |
95 | Abnormality of dentin (HP:0010299) | 1.99073016 |
96 | Hepatic necrosis (HP:0002605) | 1.97283917 |
97 | Vascular tortuosity (HP:0004948) | 1.96915616 |
98 | T lymphocytopenia (HP:0005403) | 1.96404581 |
99 | Thyroiditis (HP:0100646) | 1.95172529 |
100 | Cerebral edema (HP:0002181) | 1.95166283 |
101 | Increased CSF protein (HP:0002922) | 1.94678458 |
102 | Disproportionate short-trunk short stature (HP:0003521) | 1.94601732 |
103 | Poor head control (HP:0002421) | 1.93946486 |
104 | Recurrent bacterial skin infections (HP:0005406) | 1.93920435 |
105 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.93467005 |
106 | Hypoplasia of the odontoid process (HP:0003311) | 1.92592324 |
107 | Biconcave vertebral bodies (HP:0004586) | 1.91966823 |
108 | Acute hepatic failure (HP:0006554) | 1.91808720 |
109 | Protuberant abdomen (HP:0001538) | 1.91805369 |
110 | Abnormality of methionine metabolism (HP:0010901) | 1.91586620 |
111 | Ketosis (HP:0001946) | 1.91460282 |
112 | Decreased circulating renin level (HP:0003351) | 1.91136905 |
113 | Abnormality of dental color (HP:0011073) | 1.90936108 |
114 | Insulin resistance (HP:0000855) | 1.90895693 |
115 | Ovoid vertebral bodies (HP:0003300) | 1.90233004 |
116 | Abnormality of the basal ganglia (HP:0002134) | 1.89525504 |
117 | Alopecia of scalp (HP:0002293) | 1.88637315 |
118 | Recurrent abscess formation (HP:0002722) | 1.88547967 |
119 | Abnormality of T cell number (HP:0011839) | 1.88310416 |
120 | Osteomalacia (HP:0002749) | 1.87830822 |
121 | Axonal loss (HP:0003447) | 1.86697785 |
122 | Dysautonomia (HP:0002459) | 1.86442239 |
123 | Epiphyseal stippling (HP:0010655) | 1.85280873 |
124 | Proximal tubulopathy (HP:0000114) | 1.84912716 |
125 | Neuroendocrine neoplasm (HP:0100634) | 1.84249396 |
126 | Abdominal distention (HP:0003270) | 1.83664365 |
127 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.82926990 |
128 | Prominent metopic ridge (HP:0005487) | 1.82907020 |
129 | Aplastic anemia (HP:0001915) | 1.81742075 |
130 | Retinal dysplasia (HP:0007973) | 1.80404093 |
131 | Increased serum lactate (HP:0002151) | 1.79238971 |
132 | Fat malabsorption (HP:0002630) | 1.79216675 |
133 | Nonimmune hydrops fetalis (HP:0001790) | 1.78781436 |
134 | Degeneration of anterior horn cells (HP:0002398) | 1.76979814 |
135 | Abnormality of the anterior horn cell (HP:0006802) | 1.76979814 |
136 | CNS demyelination (HP:0007305) | 1.75106886 |
137 | Soft skin (HP:0000977) | 1.74831185 |
138 | Parakeratosis (HP:0001036) | 1.74082522 |
139 | Palmoplantar hyperkeratosis (HP:0000972) | 1.73568412 |
140 | Onycholysis (HP:0001806) | 1.72296362 |
141 | Mucosal telangiectasiae (HP:0100579) | 1.70542655 |
142 | Prostate neoplasm (HP:0100787) | 1.70322468 |
143 | Delayed CNS myelination (HP:0002188) | 1.68921572 |
144 | Abnormal spermatogenesis (HP:0008669) | 1.68778901 |
145 | Plantar hyperkeratosis (HP:0007556) | 1.67971337 |
146 | Hyperphosphatemia (HP:0002905) | 1.67619031 |
147 | Elevated alkaline phosphatase (HP:0003155) | 1.66910018 |
148 | Abnormality of the vertebral endplates (HP:0005106) | 1.66888710 |
149 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.66825782 |
150 | * Platyspondyly (HP:0000926) | 1.66430127 |
151 | Conjugated hyperbilirubinemia (HP:0002908) | 1.65299363 |
152 | Petechiae (HP:0000967) | 1.65258624 |
153 | Autoamputation (HP:0001218) | 1.64868091 |
154 | Neoplasm of the adrenal gland (HP:0100631) | 1.63775723 |
155 | Hypoplasia of the uterus (HP:0000013) | 1.63616699 |
156 | Prolonged partial thromboplastin time (HP:0003645) | 1.63283158 |
157 | Episodic fever (HP:0001954) | 1.62791291 |
158 | Hypokalemic alkalosis (HP:0001949) | 1.62423804 |
159 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.61998971 |
160 | Abnormality of alkaline phosphatase activity (HP:0004379) | 1.61967906 |
161 | Abnormality of the fovea (HP:0000493) | 1.60913857 |
162 | Epiphyseal dysplasia (HP:0002656) | 1.60629662 |
163 | Dry hair (HP:0011359) | 1.60528567 |
164 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.60013239 |
165 | Dicarboxylic aciduria (HP:0003215) | 1.60013239 |
166 | Intrahepatic cholestasis (HP:0001406) | 1.59709043 |
167 | Hypoplasia of the fovea (HP:0007750) | 1.59406668 |
168 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.59406668 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PIK3CG | 4.04803508 |
2 | MAPK15 | 3.85664609 |
3 | INSRR | 3.70817917 |
4 | EIF2AK1 | 3.70338245 |
5 | MAP3K12 | 3.57995078 |
6 | PASK | 3.23648782 |
7 | MAP4K2 | 3.10239208 |
8 | TRIM28 | 3.03979823 |
9 | IRAK3 | 2.50448688 |
10 | ERN1 | 2.47721197 |
11 | PIM2 | 2.46075339 |
12 | FRK | 2.40532973 |
13 | FLT3 | 2.38411319 |
14 | WNK4 | 2.16125336 |
15 | TAOK3 | 1.96319808 |
16 | EIF2AK3 | 1.93843873 |
17 | WNK3 | 1.80601965 |
18 | PBK | 1.78867333 |
19 | BMPR1B | 1.76021253 |
20 | VRK2 | 1.73343746 |
21 | MET | 1.72164285 |
22 | TESK2 | 1.70013215 |
23 | IRAK4 | 1.68102434 |
24 | BCKDK | 1.65719151 |
25 | ACVR1B | 1.62965721 |
26 | MST4 | 1.58667291 |
27 | HIPK2 | 1.58298101 |
28 | NME2 | 1.55429579 |
29 | SIK3 | 1.50612831 |
30 | NEK1 | 1.44227693 |
31 | TBK1 | 1.44163982 |
32 | STK24 | 1.39958147 |
33 | TESK1 | 1.39511147 |
34 | TRPM7 | 1.37727879 |
35 | ERBB3 | 1.36886189 |
36 | BUB1 | 1.30795531 |
37 | TGFBR2 | 1.27359628 |
38 | IRAK1 | 1.25144983 |
39 | MAP3K14 | 1.20406946 |
40 | LIMK1 | 1.19954314 |
41 | JAK3 | 1.17269198 |
42 | STK16 | 1.16839818 |
43 | TEC | 1.15247250 |
44 | PDK2 | 1.09235920 |
45 | GRK1 | 1.07617408 |
46 | MAP3K3 | 1.07186646 |
47 | PAK4 | 1.04744143 |
48 | PLK2 | 1.04583000 |
49 | ZAP70 | 1.03133818 |
50 | IKBKB | 0.98997158 |
51 | EPHA3 | 0.94821452 |
52 | BMPR2 | 0.91773893 |
53 | STK10 | 0.91215413 |
54 | IKBKE | 0.90757030 |
55 | NTRK1 | 0.90232020 |
56 | CAMKK2 | 0.89497400 |
57 | PLK3 | 0.87875409 |
58 | GRK7 | 0.87342792 |
59 | MAP3K2 | 0.86870569 |
60 | ITK | 0.86784941 |
61 | PLK4 | 0.85311825 |
62 | SCYL2 | 0.85048809 |
63 | NEK9 | 0.84882748 |
64 | SRPK1 | 0.84719305 |
65 | ADRBK2 | 0.84361209 |
66 | PRKG2 | 0.83899464 |
67 | PAK3 | 0.83877582 |
68 | MAP2K2 | 0.83769973 |
69 | MAPKAPK5 | 0.82038290 |
70 | NUAK1 | 0.81868952 |
71 | STK39 | 0.81290519 |
72 | BTK | 0.80547665 |
73 | DDR2 | 0.80014481 |
74 | PDGFRA | 0.79464233 |
75 | MARK3 | 0.79399126 |
76 | ARAF | 0.78736522 |
77 | TGFBR1 | 0.78733664 |
78 | CDK8 | 0.76953456 |
79 | STK3 | 0.75416916 |
80 | BLK | 0.75286870 |
81 | TYK2 | 0.75279055 |
82 | PRKD3 | 0.73567472 |
83 | KIT | 0.72787208 |
84 | TXK | 0.70902330 |
85 | DYRK1B | 0.70736233 |
86 | MOS | 0.70375618 |
87 | EPHA2 | 0.70323315 |
88 | TIE1 | 0.69741674 |
89 | MATK | 0.68855065 |
90 | ILK | 0.66775030 |
91 | FER | 0.66515421 |
92 | BRAF | 0.66401978 |
93 | PTK2 | 0.66109180 |
94 | PTK6 | 0.65472912 |
95 | EPHB1 | 0.65284266 |
96 | VRK1 | 0.64972148 |
97 | NLK | 0.63516768 |
98 | PRPF4B | 0.62950874 |
99 | PRKCI | 0.62881622 |
100 | MYLK | 0.62042057 |
101 | NEK6 | 0.61132755 |
102 | ZAK | 0.59939558 |
103 | EIF2AK2 | 0.59694162 |
104 | RPS6KA4 | 0.58276683 |
105 | JAK1 | 0.57962116 |
106 | BRSK2 | 0.55360932 |
107 | CDK3 | 0.54768998 |
108 | CSNK1G3 | 0.54224614 |
109 | DAPK1 | 0.53715178 |
110 | PRKCE | 0.52993393 |
111 | LATS1 | 0.52723618 |
112 | IGF1R | 0.52464465 |
113 | FGFR3 | 0.51753346 |
114 | CHUK | 0.50816704 |
115 | DYRK3 | 0.50669906 |
116 | WNK1 | 0.48596301 |
117 | WEE1 | 0.47759684 |
118 | RPS6KA5 | 0.47549351 |
119 | LYN | 0.46805319 |
120 | MAPKAPK3 | 0.46512654 |
121 | CSK | 0.46301447 |
122 | MST1R | 0.45367714 |
123 | SIK1 | 0.44968330 |
124 | ABL2 | 0.44430585 |
125 | CAMK2D | 0.43174940 |
126 | TAF1 | 0.43010331 |
127 | CSNK1G1 | 0.42303388 |
128 | MAPKAPK2 | 0.41875588 |
129 | CDC42BPA | 0.41193050 |
130 | STK4 | 0.40961207 |
131 | UHMK1 | 0.40910972 |
132 | PIK3CA | 0.39725939 |
133 | SYK | 0.38620383 |
134 | TTK | 0.38044526 |
135 | CSF1R | 0.36719211 |
136 | ABL1 | 0.36140564 |
137 | RPS6KB2 | 0.36089195 |
138 | PRKCD | 0.35628886 |
139 | AKT3 | 0.35408548 |
140 | IRAK2 | 0.34975553 |
141 | BCR | 0.34772839 |
142 | STK38L | 0.34642045 |
143 | FGFR1 | 0.33976855 |
144 | CSNK2A1 | 0.33244970 |
145 | FGFR2 | 0.32916427 |
146 | CSNK2A2 | 0.31133367 |
147 | PLK1 | 0.30535997 |
148 | AURKB | 0.29622890 |
149 | FES | 0.29573001 |
150 | PRKD2 | 0.29377869 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Protein export_Homo sapiens_hsa03060 | 7.25790662 |
2 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 6.07604181 |
3 | Sulfur metabolism_Homo sapiens_hsa00920 | 3.69764436 |
4 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 3.09828638 |
5 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.28094512 |
6 | * Lysosome_Homo sapiens_hsa04142 | 2.27446330 |
7 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 2.26211125 |
8 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.19928705 |
9 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.08457343 |
10 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 2.01177767 |
11 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.00529565 |
12 | * Other glycan degradation_Homo sapiens_hsa00511 | 1.96041867 |
13 | Mismatch repair_Homo sapiens_hsa03430 | 1.83492283 |
14 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.81758096 |
15 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.76969817 |
16 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.71600101 |
17 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.61083554 |
18 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.58687773 |
19 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.56269318 |
20 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.50231457 |
21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.45884453 |
22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.41340906 |
23 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.40433969 |
24 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.38623778 |
25 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.37298964 |
26 | DNA replication_Homo sapiens_hsa03030 | 1.35488610 |
27 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.31806144 |
28 | Base excision repair_Homo sapiens_hsa03410 | 1.27801620 |
29 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.27502255 |
30 | Basal transcription factors_Homo sapiens_hsa03022 | 1.27480747 |
31 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.23207941 |
32 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.18578895 |
33 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.17463903 |
34 | Histidine metabolism_Homo sapiens_hsa00340 | 1.15232091 |
35 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.14918270 |
36 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.13388007 |
37 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.10976051 |
38 | Galactose metabolism_Homo sapiens_hsa00052 | 1.09829984 |
39 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.09647026 |
40 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.09314628 |
41 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.09131104 |
42 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.08705138 |
43 | Homologous recombination_Homo sapiens_hsa03440 | 1.08238779 |
44 | Legionellosis_Homo sapiens_hsa05134 | 1.01405123 |
45 | Phagosome_Homo sapiens_hsa04145 | 1.00074582 |
46 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.99095674 |
47 | Peroxisome_Homo sapiens_hsa04146 | 0.98615787 |
48 | Malaria_Homo sapiens_hsa05144 | 0.96849301 |
49 | Ribosome_Homo sapiens_hsa03010 | 0.96107963 |
50 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.95994718 |
51 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.95483332 |
52 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.94998604 |
53 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.93034236 |
54 | RNA polymerase_Homo sapiens_hsa03020 | 0.92665797 |
55 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.91615248 |
56 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.90692028 |
57 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.88988728 |
58 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.87935540 |
59 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.84860216 |
60 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.83814533 |
61 | RNA degradation_Homo sapiens_hsa03018 | 0.82608204 |
62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.82510472 |
63 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.81909433 |
64 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.79315213 |
65 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.78143420 |
66 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.77806971 |
67 | Insulin secretion_Homo sapiens_hsa04911 | 0.77280521 |
68 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.76778808 |
69 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.76397754 |
70 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.74991061 |
71 | Proteasome_Homo sapiens_hsa03050 | 0.73573131 |
72 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.70375918 |
73 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.70042987 |
74 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.68796350 |
75 | Parkinsons disease_Homo sapiens_hsa05012 | 0.64931550 |
76 | Retinol metabolism_Homo sapiens_hsa00830 | 0.64631703 |
77 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.64490551 |
78 | ABC transporters_Homo sapiens_hsa02010 | 0.64397681 |
79 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.61057871 |
80 | Allograft rejection_Homo sapiens_hsa05330 | 0.60973649 |
81 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.57920999 |
82 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.57196448 |
83 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.56466617 |
84 | Alzheimers disease_Homo sapiens_hsa05010 | 0.55753846 |
85 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.54865586 |
86 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.52560157 |
87 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.52384023 |
88 | Metabolic pathways_Homo sapiens_hsa01100 | 0.50759389 |
89 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.50318897 |
90 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.48929728 |
91 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.46988858 |
92 | Leishmaniasis_Homo sapiens_hsa05140 | 0.46661428 |
93 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.45435265 |
94 | Pertussis_Homo sapiens_hsa05133 | 0.45380712 |
95 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.45120900 |
96 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.45073220 |
97 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.45013649 |
98 | Prion diseases_Homo sapiens_hsa05020 | 0.44873185 |
99 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.44279388 |
100 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.41767146 |
101 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.41676550 |
102 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.41565431 |
103 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.41279852 |
104 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.40347257 |
105 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.40018956 |
106 | Asthma_Homo sapiens_hsa05310 | 0.37625252 |
107 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.37246268 |
108 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.36728546 |
109 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.36469718 |
110 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.33863408 |
111 | Measles_Homo sapiens_hsa05162 | 0.32650552 |
112 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.32415362 |
113 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.32384469 |
114 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.30826568 |
115 | Sulfur relay system_Homo sapiens_hsa04122 | 0.29986067 |
116 | Apoptosis_Homo sapiens_hsa04210 | 0.28116959 |
117 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.27403648 |
118 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.26946613 |
119 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.26867013 |
120 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.25463205 |
121 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.24719081 |
122 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.24616915 |
123 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.24083010 |
124 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.22361412 |
125 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.22237089 |
126 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.21551685 |
127 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.21160873 |
128 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.20075187 |
129 | Huntingtons disease_Homo sapiens_hsa05016 | 0.19119462 |