AGA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.71101963
2Golgi transport vesicle coating (GO:0048200)8.71101963
3signal peptide processing (GO:0006465)8.70178089
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.98651959
5protein retention in ER lumen (GO:0006621)6.35049025
6COPII vesicle coating (GO:0048208)5.69623140
7protein maturation by protein folding (GO:0022417)5.10437566
8sequestering of metal ion (GO:0051238)5.06023244
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.85369524
10endocrine pancreas development (GO:0031018)4.70097768
11ER overload response (GO:0006983)4.69403444
12peptide hormone processing (GO:0016486)4.43766296
13regulation of type B pancreatic cell apoptotic process (GO:2000674)4.40015382
14proteasome assembly (GO:0043248)4.30682576
15regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.86535508
16activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.85446648
17nucleotide transmembrane transport (GO:1901679)3.84414665
18exocrine pancreas development (GO:0031017)3.72756885
19protein N-linked glycosylation via asparagine (GO:0018279)3.70300394
20positive regulation of nuclease activity (GO:0032075)3.68310226
21GDP-mannose metabolic process (GO:0019673)3.65963114
22ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.64875568
23peptidyl-asparagine modification (GO:0018196)3.63474730
24cellular response to unfolded protein (GO:0034620)3.55375536
25ER to Golgi vesicle-mediated transport (GO:0006888)3.55364429
26endoplasmic reticulum unfolded protein response (GO:0030968)3.53936825
27cellular response to vitamin D (GO:0071305)3.50484572
28cellular response to topologically incorrect protein (GO:0035967)3.47463777
29protein N-linked glycosylation (GO:0006487)3.43672036
30regulation of nuclease activity (GO:0032069)3.43176164
31glandular epithelial cell differentiation (GO:0002067)3.31374674
32vesicle coating (GO:0006901)3.28670661
33negative regulation of glycoprotein biosynthetic process (GO:0010561)3.25219859
34ER-nucleus signaling pathway (GO:0006984)3.24966390
35fucose metabolic process (GO:0006004)3.23682114
36regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.21665148
37synapsis (GO:0007129)3.19927394
38positive regulation of insulin secretion (GO:0032024)3.19505611
39nucleotide-sugar biosynthetic process (GO:0009226)3.16678992
40keratan sulfate catabolic process (GO:0042340)3.13225821
41protein deneddylation (GO:0000338)3.07438709
42cullin deneddylation (GO:0010388)3.06634328
43peptide catabolic process (GO:0043171)3.03145529
44toxin metabolic process (GO:0009404)3.01921921
45response to endoplasmic reticulum stress (GO:0034976)3.01921005
46regulation of metalloenzyme activity (GO:0048552)3.01666803
47negative regulation of glycoprotein metabolic process (GO:1903019)3.00545613
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97695944
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95836723
50mannosylation (GO:0097502)2.95702873
51antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.95317180
52cellular response to vitamin (GO:0071295)2.94519941
53piRNA metabolic process (GO:0034587)2.92905935
54peptide metabolic process (GO:0006518)2.92160009
55glycoside metabolic process (GO:0016137)2.90434686
56regulation of meiosis I (GO:0060631)2.89384194
57neutrophil activation involved in immune response (GO:0002283)2.88246940
58regulation of cellular amino acid metabolic process (GO:0006521)2.87502659
59UDP-N-acetylglucosamine metabolic process (GO:0006047)2.86892342
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86094649
61cellular ketone body metabolic process (GO:0046950)2.85438771
62platelet dense granule organization (GO:0060155)2.85321981
63C-terminal protein lipidation (GO:0006501)2.84982689
64amyloid precursor protein catabolic process (GO:0042987)2.84024420
65purine nucleotide salvage (GO:0032261)2.83752098
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80825220
67nucleoside diphosphate catabolic process (GO:0009134)2.80371203
68glucosamine-containing compound catabolic process (GO:1901072)2.78435021
69type B pancreatic cell development (GO:0003323)2.78200351
70dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.76567547
71virion attachment to host cell (GO:0019062)2.75770833
72adhesion of symbiont to host cell (GO:0044650)2.75770833
73ketone body metabolic process (GO:1902224)2.75545419
74purine-containing compound salvage (GO:0043101)2.75463060
75response to unfolded protein (GO:0006986)2.75297409
76mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.74688721
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73024240
78response to topologically incorrect protein (GO:0035966)2.71622223
79eosinophil chemotaxis (GO:0048245)2.67930224
80regulation of DNA endoreduplication (GO:0032875)2.66566862
81regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.66460006
82G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.65512714
83nucleotide-sugar metabolic process (GO:0009225)2.65499270
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64211613
85negative regulation of ligase activity (GO:0051352)2.64211613
86DNA ligation (GO:0006266)2.64067454
87signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.62511038
88signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.62511038
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.62511038
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.62432075
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.62432075
92cell redox homeostasis (GO:0045454)2.61814840
93cellular zinc ion homeostasis (GO:0006882)2.59045292
94glandular epithelial cell development (GO:0002068)2.54413994
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.54044872
96cellular response to ATP (GO:0071318)2.53993183
97positive regulation of peptide hormone secretion (GO:0090277)2.53572878
98negative regulation of JUN kinase activity (GO:0043508)2.53395394
99protein autoprocessing (GO:0016540)2.53346172
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.53324784
101negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.52983343
102glycolipid catabolic process (GO:0019377)2.52722683
103antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52248256
104antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52248256
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.51393509
106L-phenylalanine metabolic process (GO:0006558)2.51393509
107polyketide metabolic process (GO:0030638)2.48023300
108doxorubicin metabolic process (GO:0044598)2.48023300
109daunorubicin metabolic process (GO:0044597)2.48023300
110cellular response to hepatocyte growth factor stimulus (GO:0035729)2.47891340
111response to hepatocyte growth factor (GO:0035728)2.47891340
112signal transduction involved in DNA integrity checkpoint (GO:0072401)2.47723086
113signal transduction involved in DNA damage checkpoint (GO:0072422)2.47723086
114purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.45855528
1153-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.45855528
116glycosphingolipid catabolic process (GO:0046479)2.45655681
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.45623684
118positive regulation of ligase activity (GO:0051351)2.44867133
119response to redox state (GO:0051775)2.44698677
120negative regulation of norepinephrine secretion (GO:0010700)2.44305660
121preassembly of GPI anchor in ER membrane (GO:0016254)2.44157373
122somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.43960341
123somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.43960341
124isotype switching (GO:0045190)2.43960341
125response to hydroperoxide (GO:0033194)2.43054802
126ribosome assembly (GO:0042255)2.42488752
127GPI anchor biosynthetic process (GO:0006506)2.42379261
128cellular response to antibiotic (GO:0071236)2.41832421
129intra-Golgi vesicle-mediated transport (GO:0006891)2.41620700
130signal transduction involved in cell cycle checkpoint (GO:0072395)2.39980507
131interleukin-1-mediated signaling pathway (GO:0070498)2.39874836
132negative regulation of bone resorption (GO:0045779)2.38831208
133modulation of growth of symbiont involved in interaction with host (GO:0044144)2.38466303
134regulation of growth of symbiont in host (GO:0044126)2.38466303
135negative regulation of growth of symbiont in host (GO:0044130)2.38466303
136negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.38466303
137regulation of glucokinase activity (GO:0033131)2.38231870
138regulation of hexokinase activity (GO:1903299)2.38231870
139L-phenylalanine catabolic process (GO:0006559)2.38106789
140erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.38106789
141regulation of integrin-mediated signaling pathway (GO:2001044)2.37321203
142magnesium ion transport (GO:0015693)2.37167447
143positive regulation of peptide secretion (GO:0002793)2.36712878
144organelle membrane fusion (GO:0090174)2.36522630
1454-hydroxyproline metabolic process (GO:0019471)2.36001327
146nucleotide transport (GO:0006862)2.35968609
147ceramide catabolic process (GO:0046514)2.35966363
148protein neddylation (GO:0045116)2.35274622
149protein complex biogenesis (GO:0070271)2.34678509
150positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.34159960
151production of molecular mediator involved in inflammatory response (GO:0002532)2.34152259
152ATP synthesis coupled proton transport (GO:0015986)2.33793814
153energy coupled proton transport, down electrochemical gradient (GO:0015985)2.33793814
154regulation of insulin secretion (GO:0050796)2.33178044
155nucleoside salvage (GO:0043174)2.32707510
156S-adenosylmethionine metabolic process (GO:0046500)2.31648076
157mitochondrial respiratory chain complex assembly (GO:0033108)2.31613066
158eosinophil migration (GO:0072677)2.31251850
159adenosine metabolic process (GO:0046085)2.31183530
160antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.30381070
161proline biosynthetic process (GO:0006561)2.30334949
162negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.30083578
163regulation of regulatory T cell differentiation (GO:0045589)2.29947368
164oligosaccharide catabolic process (GO:0009313)2.29828015
165pteridine-containing compound biosynthetic process (GO:0042559)2.29496737
166cytochrome complex assembly (GO:0017004)2.28164170
167keratinocyte development (GO:0003334)2.27740275
168C-terminal protein amino acid modification (GO:0018410)2.26565250
169sphingosine metabolic process (GO:0006670)2.26187376
170regulation of B cell apoptotic process (GO:0002902)2.25220711
171transcytosis (GO:0045056)2.23156232
172tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.19231791
173RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.19231791
174heme metabolic process (GO:0042168)2.18441862
175B cell activation involved in immune response (GO:0002312)2.18296100
176type B pancreatic cell proliferation (GO:0044342)2.16851746
177sphingoid metabolic process (GO:0046519)2.16149612
178negative regulation of complement activation (GO:0045916)2.14829163
179heme biosynthetic process (GO:0006783)2.14231379
180Arp2/3 complex-mediated actin nucleation (GO:0034314)2.13609497
181regulation of ubiquitin-protein transferase activity (GO:0051438)2.13418935
182respiratory chain complex IV assembly (GO:0008535)2.10088848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.57410967
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.19479663
3GATA1_22025678_ChIP-Seq_K562_Human3.42984590
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.41539966
5PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.36172924
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.11466695
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76596936
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62041735
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48450664
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45178861
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.38034571
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.36847531
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19474103
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.16832378
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.06003314
16TFEB_21752829_ChIP-Seq_HELA_Human2.05187392
17* SRF_21415370_ChIP-Seq_HL-1_Mouse2.03715335
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.94946020
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91458397
20FOXP3_21729870_ChIP-Seq_TREG_Human1.91070355
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87135358
22ERG_20887958_ChIP-Seq_HPC-7_Mouse1.87025682
23ELK1_19687146_ChIP-ChIP_HELA_Human1.79508940
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.72129622
25E2F7_22180533_ChIP-Seq_HELA_Human1.70944234
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69798827
27SOX2_20726797_ChIP-Seq_SW620_Human1.69282175
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67505587
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63749434
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61125865
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61018032
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60854683
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.60056984
34ELK1_22589737_ChIP-Seq_MCF10A_Human1.59784777
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58082921
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57875145
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53694565
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53070779
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51903311
40CLOCK_20551151_ChIP-Seq_293T_Human1.51724355
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.51594644
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51311630
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48385781
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46567047
45* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46334016
46* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46334016
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45084827
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43241082
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41997851
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.40551435
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39654697
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39533259
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38999039
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.37138419
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35333473
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32968525
57MYB_26560356_Chip-Seq_TH2_Human1.32551739
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32301825
59FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31889368
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31462222
61ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31177608
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30227105
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.28287967
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28152708
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27763135
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.27477580
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26908709
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25311619
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24447844
70* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22667576
71* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21134605
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21014561
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20704994
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19729231
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18926094
76* SPI1_23547873_ChIP-Seq_NB4_Human1.17998497
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.17817275
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17797815
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17141169
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16489665
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16054522
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14156227
83SALL4_22934838_ChIP-ChIP_CD34+_Human1.13995255
84ELF5_23300383_ChIP-Seq_T47D_Human1.13740174
85* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13541786
86GABP_19822575_ChIP-Seq_HepG2_Human1.13098462
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11940120
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11664142
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11161975
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09315053
91SOX17_20123909_ChIP-Seq_XEN_Mouse1.09150410
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09053695
93* AR_20517297_ChIP-Seq_VCAP_Human1.08774995
94VDR_23849224_ChIP-Seq_CD4+_Human1.08321918
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07862888
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07542519
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.07159303
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06610999
99BRD4_25478319_ChIP-Seq_HGPS_Human1.06430584
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06183689
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.05745953
102IRF8_27001747_Chip-Seq_BMDM_Mouse1.05610749
103GATA4_25053715_ChIP-Seq_YYC3_Human1.05421784
104DCP1A_22483619_ChIP-Seq_HELA_Human1.05190833
105GATA3_26560356_Chip-Seq_TH2_Human1.02984443
106MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02637390
107* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02501328
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01855900
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.01523527
110ETS1_20019798_ChIP-Seq_JURKAT_Human1.01439531
111FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01160127
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00714592
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99787392
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98844229
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98446080
116MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98372745
117NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98234408
118AR_21909140_ChIP-Seq_LNCAP_Human0.98213608
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97482909
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97353362
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97226093
122CJUN_26792858_Chip-Seq_BT549_Human0.97174643
123GATA3_27048872_Chip-Seq_THYMUS_Human0.96832239
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.95666269
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94610006
126MYC_18555785_ChIP-Seq_MESCs_Mouse0.94606694
127FUS_26573619_Chip-Seq_HEK293_Human0.94308319
128ZNF274_21170338_ChIP-Seq_K562_Hela0.93776875
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93387293
130STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93047920
131MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92727267
132FOXA1_25552417_ChIP-Seq_VCAP_Human0.91991748
133NFE2_27457419_Chip-Seq_LIVER_Mouse0.91836281
134STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91780769
135* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91165866
136HTT_18923047_ChIP-ChIP_STHdh_Human0.89297532
137ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88402424
138MYB_26560356_Chip-Seq_TH1_Human0.87927684
139TTF2_22483619_ChIP-Seq_HELA_Human0.87733009
140ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85871566
141EWS_26573619_Chip-Seq_HEK293_Human0.85668468
142FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83538533
143CDX2_22108803_ChIP-Seq_LS180_Human0.83002187
144MYC_18940864_ChIP-ChIP_HL60_Human0.82011637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue4.07835335
2MP0008438_abnormal_cutaneous_collagen3.85348964
3MP0002877_abnormal_melanocyte_morpholog3.69388374
4MP0003195_calcinosis3.56669270
5MP0003183_abnormal_peptide_metabolism3.28796983
6MP0004043_abnormal_pH_regulation2.96071731
7MP0005220_abnormal_exocrine_pancreas2.85532181
8MP0005379_endocrine/exocrine_gland_phen2.77863541
9MP0006054_spinal_hemorrhage2.77826113
10MP0002693_abnormal_pancreas_physiology2.72489812
11* MP0005058_abnormal_lysosome_morphology2.48661468
12MP0001944_abnormal_pancreas_morphology2.40651780
13MP0003191_abnormal_cellular_cholesterol2.34821435
14MP0003950_abnormal_plasma_membrane2.26035446
15MP0003283_abnormal_digestive_organ2.16662821
16MP0008007_abnormal_cellular_replicative2.07137360
17MP0005503_abnormal_tendon_morphology2.01039494
18MP0000003_abnormal_adipose_tissue1.97695423
19MP0003279_aneurysm1.95343052
20MP0003172_abnormal_lysosome_physiology1.94128791
21MP0001853_heart_inflammation1.87546340
22MP0005075_abnormal_melanosome_morpholog1.85425940
23MP0009840_abnormal_foam_cell1.80137811
24MP0003806_abnormal_nucleotide_metabolis1.79824366
25MP0003656_abnormal_erythrocyte_physiolo1.74219207
26MP0003724_increased_susceptibility_to1.72630116
27MP0002837_dystrophic_cardiac_calcinosis1.70339580
28MP0002166_altered_tumor_susceptibility1.67967384
29MP0003186_abnormal_redox_activity1.66909382
30MP0005084_abnormal_gallbladder_morpholo1.66516613
31MP0005275_abnormal_skin_tensile1.65171747
32MP0002909_abnormal_adrenal_gland1.65072873
33MP0009384_cardiac_valve_regurgitation1.59769859
34MP0005645_abnormal_hypothalamus_physiol1.59566577
35MP0009780_abnormal_chondrocyte_physiolo1.55052310
36MP0008058_abnormal_DNA_repair1.49642563
37MP0003786_premature_aging1.47649463
38MP0002933_joint_inflammation1.47505932
39MP0003011_delayed_dark_adaptation1.47439093
40MP0000678_abnormal_parathyroid_gland1.47373598
41MP0004147_increased_porphyrin_level1.44510682
42MP0002006_tumorigenesis1.43094232
43MP0006036_abnormal_mitochondrial_physio1.42633727
44MP0002295_abnormal_pulmonary_circulatio1.40656542
45MP0005408_hypopigmentation1.39388334
46MP0002078_abnormal_glucose_homeostasis1.39225244
47MP0005365_abnormal_bile_salt1.38986347
48* MP0009643_abnormal_urine_homeostasis1.38678505
49MP0002452_abnormal_antigen_presenting1.37474789
50MP0001533_abnormal_skeleton_physiology1.37204093
51* MP0010386_abnormal_urinary_bladder1.35503456
52MP0002138_abnormal_hepatobiliary_system1.34609689
53MP0001958_emphysema1.34331847
54MP0008877_abnormal_DNA_methylation1.34177540
55MP0005025_abnormal_response_to1.34032347
56MP0002896_abnormal_bone_mineralization1.33927770
57MP0002928_abnormal_bile_duct1.28774205
58MP0010094_abnormal_chromosome_stability1.27643100
59MP0000465_gastrointestinal_hemorrhage1.27298949
60MP0003795_abnormal_bone_structure1.27277981
61MP0002723_abnormal_immune_serum1.26591414
62MP0003959_abnormal_lean_body1.25412097
63MP0002163_abnormal_gland_morphology1.25086156
64MP0003252_abnormal_bile_duct1.24120852
65MP0006082_CNS_inflammation1.23939667
66MP0001986_abnormal_taste_sensitivity1.23934432
67MP0008875_abnormal_xenobiotic_pharmacok1.23827264
68MP0001542_abnormal_bone_strength1.22715990
69MP0001800_abnormal_humoral_immune1.21150798
70MP0008057_abnormal_DNA_replication1.20586779
71MP0002405_respiratory_system_inflammati1.18984130
72MP0002148_abnormal_hypersensitivity_rea1.18810373
73MP0000613_abnormal_salivary_gland1.18303761
74MP0001835_abnormal_antigen_presentation1.18155544
75MP0009697_abnormal_copulation1.18031743
76MP0005464_abnormal_platelet_physiology1.17482404
77MP0000604_amyloidosis1.15116477
78MP0002139_abnormal_hepatobiliary_system1.14830519
79MP0002420_abnormal_adaptive_immunity1.13536682
80MP0005171_absent_coat_pigmentation1.12998645
81MP0001819_abnormal_immune_cell1.11941678
82MP0003300_gastrointestinal_ulcer1.10314031
83MP0003436_decreased_susceptibility_to1.10197318
84MP0005390_skeleton_phenotype1.09849998
85MP0010234_abnormal_vibrissa_follicle1.09330204
86MP0004272_abnormal_basement_membrane1.07703713
87MP0000015_abnormal_ear_pigmentation1.06357723
88MP0001666_abnormal_nutrient_absorption1.06350032
89MP0005257_abnormal_intraocular_pressure1.06053867
90MP0005508_abnormal_skeleton_morphology1.05921965
91MP0000371_diluted_coat_color1.05038392
92MP0002998_abnormal_bone_remodeling1.04927042
93MP0002060_abnormal_skin_morphology1.01438956
94MP0010352_gastrointestinal_tract_polyps1.00747904
95MP0002419_abnormal_innate_immunity0.99976905
96MP0000372_irregular_coat_pigmentation0.99283239
97MP0002090_abnormal_vision0.98353207
98MP0001243_abnormal_dermal_layer0.98036920
99MP0001756_abnormal_urination0.97830639
100MP0000689_abnormal_spleen_morphology0.95425499
101MP0005000_abnormal_immune_tolerance0.95193541
102MP0005671_abnormal_response_to0.95136375
103MP0003075_altered_response_to0.95069241
104MP0005319_abnormal_enzyme/_coenzyme0.94140469
105MP0009785_altered_susceptibility_to0.92929724
106MP0000163_abnormal_cartilage_morphology0.92329194
107MP0006072_abnormal_retinal_apoptosis0.92311591
108MP0005636_abnormal_mineral_homeostasis0.91876841
109MP0004264_abnormal_extraembryonic_tissu0.91611089
110MP0000681_abnormal_thyroid_gland0.91294458
111MP0002396_abnormal_hematopoietic_system0.90412248
112MP0005174_abnormal_tail_pigmentation0.90276587
113MP0001764_abnormal_homeostasis0.89406298
114MP0000358_abnormal_cell_content/0.88678969
115MP0002254_reproductive_system_inflammat0.88478832
116MP0008260_abnormal_autophagy0.88410073
117MP0009764_decreased_sensitivity_to0.88388719
118MP0003303_peritoneal_inflammation0.87897523
119MP0005165_increased_susceptibility_to0.86429185
120MP0009763_increased_sensitivity_to0.86235853
121MP0000858_altered_metastatic_potential0.86179950
122MP0001790_abnormal_immune_system0.86022354
123MP0005387_immune_system_phenotype0.86022354
124MP0004947_skin_inflammation0.85992928
125MP0005646_abnormal_pituitary_gland0.85237916
126MP0001299_abnormal_eye_distance/0.85040837
127MP0004782_abnormal_surfactant_physiolog0.84999373
128MP0010329_abnormal_lipoprotein_level0.84282120
129MP0000685_abnormal_immune_system0.84176779
130MP0003763_abnormal_thymus_physiology0.83604001
131MP0000343_altered_response_to0.83578598
132MP0002938_white_spotting0.81984330
133MP0005375_adipose_tissue_phenotype0.81383931
134MP0000609_abnormal_liver_physiology0.81216372
135MP0008469_abnormal_protein_level0.81165114
136MP0000716_abnormal_immune_system0.79607856
137MP0001765_abnormal_ion_homeostasis0.78817776
138MP0001845_abnormal_inflammatory_respons0.78343009
139MP0005332_abnormal_amino_acid0.76414162
140MP0005164_abnormal_response_to0.74915086
141MP0000230_abnormal_systemic_arterial0.74049954
142MP0005023_abnormal_wound_healing0.73327468
143MP0001661_extended_life_span0.72027346
144MP0000920_abnormal_myelination0.71955719
145MP0002876_abnormal_thyroid_physiology0.71798700
146MP0000639_abnormal_adrenal_gland0.71677386
147MP0002638_abnormal_pupillary_reflex0.70861324
148MP0003868_abnormal_feces_composition0.70639850
149MP0002168_other_aberrant_phenotype0.69478977
150MP0003953_abnormal_hormone_level0.69460941
151MP0001348_abnormal_lacrimal_gland0.68837014
152MP0009333_abnormal_splenocyte_physiolog0.68086628

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.39710045
2Hypoglycemic seizures (HP:0002173)5.10098876
3Hyperinsulinemic hypoglycemia (HP:0000825)4.95833064
4Symptomatic seizures (HP:0011145)4.71071849
5Generalized aminoaciduria (HP:0002909)4.01440844
6Abnormality of the intrinsic pathway (HP:0010989)3.81583388
7Urinary glycosaminoglycan excretion (HP:0003541)3.81134959
8Mucopolysacchariduria (HP:0008155)3.81134959
9* Dysostosis multiplex (HP:0000943)3.80217735
10Abnormal protein glycosylation (HP:0012346)3.44342849
11Abnormal glycosylation (HP:0012345)3.44342849
12Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.44342849
13Abnormal protein N-linked glycosylation (HP:0012347)3.44342849
14Abnormality of polysaccharide metabolism (HP:0011012)3.41998368
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.41998368
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.41998368
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.37921281
18Type I transferrin isoform profile (HP:0003642)3.36413047
19Loss of speech (HP:0002371)3.22556811
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.13838480
21Cervical subluxation (HP:0003308)3.12115540
22Ketoacidosis (HP:0001993)3.08936118
23Vertebral compression fractures (HP:0002953)3.00790208
24Abnormality of liposaccharide metabolism (HP:0010968)2.99955101
25Abnormality of glycosphingolipid metabolism (HP:0004343)2.99955101
26Abnormality of glycolipid metabolism (HP:0010969)2.99955101
27Hyperglycemia (HP:0003074)2.98936814
28Pancreatic islet-cell hyperplasia (HP:0004510)2.97528427
29Abnormality of the pancreatic islet cells (HP:0006476)2.95138811
30Abnormality of endocrine pancreas physiology (HP:0012093)2.95138811
31Large for gestational age (HP:0001520)2.90345886
32Late onset (HP:0003584)2.88409236
33Progressive neurologic deterioration (HP:0002344)2.87130370
34Metaphyseal dysplasia (HP:0100255)2.84819679
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.77106401
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.75223295
37Insulin-resistant diabetes mellitus (HP:0000831)2.62102985
38Mitochondrial inheritance (HP:0001427)2.59611146
39Premature rupture of membranes (HP:0001788)2.55593135
40Abnormality of macrophages (HP:0004311)2.54933012
41Progressive macrocephaly (HP:0004481)2.53703594
42Abnormality of calcium-phosphate metabolism (HP:0100530)2.53693580
43Hypothermia (HP:0002045)2.53325035
443-Methylglutaconic aciduria (HP:0003535)2.51671063
45Hepatocellular necrosis (HP:0001404)2.49472926
46Stomatitis (HP:0010280)2.49162632
47Increased CSF lactate (HP:0002490)2.48701921
48Acute necrotizing encephalopathy (HP:0006965)2.48461350
49* Vacuolated lymphocytes (HP:0001922)2.48413426
50Agnosia (HP:0010524)2.46977116
51Abnormality of the common coagulation pathway (HP:0010990)2.43475349
52Retinal atrophy (HP:0001105)2.42140264
53Prolonged neonatal jaundice (HP:0006579)2.40823790
54Conjunctival hamartoma (HP:0100780)2.39949547
55Increased serum pyruvate (HP:0003542)2.36251487
56Increased cerebral lipofuscin (HP:0011813)2.35804137
57Vascular calcification (HP:0004934)2.35290499
58Flat capital femoral epiphysis (HP:0003370)2.34065567
59Congenital, generalized hypertrichosis (HP:0004540)2.31550313
60Joint stiffness (HP:0001387)2.30601393
61Lipid accumulation in hepatocytes (HP:0006561)2.30470428
62Reduced antithrombin III activity (HP:0001976)2.29531577
63Follicular hyperkeratosis (HP:0007502)2.28407924
64* Beaking of vertebral bodies (HP:0004568)2.28263695
65Renal Fanconi syndrome (HP:0001994)2.26484985
66Steatorrhea (HP:0002570)2.26114469
67Abnormal pancreas size (HP:0012094)2.26072010
68Hypokinesia (HP:0002375)2.26032297
69Sparse eyelashes (HP:0000653)2.24954069
70Disinhibition (HP:0000734)2.23778493
71Glycosuria (HP:0003076)2.23046404
72Abnormality of urine glucose concentration (HP:0011016)2.23046404
73Cardiovascular calcification (HP:0011915)2.21538441
74Protrusio acetabuli (HP:0003179)2.20589569
75Irregular vertebral endplates (HP:0003301)2.18562576
76Hyperparathyroidism (HP:0000843)2.16526708
77Thoracolumbar scoliosis (HP:0002944)2.16517102
78Flared iliac wings (HP:0002869)2.14877835
79Hepatosplenomegaly (HP:0001433)2.14425919
80Increased hepatocellular lipid droplets (HP:0006565)2.12827067
81Exocrine pancreatic insufficiency (HP:0001738)2.12451176
82Abnormal tarsal ossification (HP:0008369)2.11716325
83Acute encephalopathy (HP:0006846)2.11646646
84Renal cortical cysts (HP:0000803)2.11468754
85Respiratory failure (HP:0002878)2.11307424
86Exertional dyspnea (HP:0002875)2.08596808
87Abnormal mitochondria in muscle tissue (HP:0008316)2.08575173
88Hypokalemia (HP:0002900)2.08137427
89Abnormality of glycolysis (HP:0004366)2.07081215
90Abnormality of the distal phalanges of the toes (HP:0010182)2.06626621
91Spastic paraparesis (HP:0002313)2.06261685
92Abnormality of the prostate (HP:0008775)2.00733483
93Wormian bones (HP:0002645)2.00499811
94Abnormal foot bone ossification (HP:0010675)1.99891428
95Abnormality of dentin (HP:0010299)1.99073016
96Hepatic necrosis (HP:0002605)1.97283917
97Vascular tortuosity (HP:0004948)1.96915616
98T lymphocytopenia (HP:0005403)1.96404581
99Thyroiditis (HP:0100646)1.95172529
100Cerebral edema (HP:0002181)1.95166283
101Increased CSF protein (HP:0002922)1.94678458
102Disproportionate short-trunk short stature (HP:0003521)1.94601732
103Poor head control (HP:0002421)1.93946486
104Recurrent bacterial skin infections (HP:0005406)1.93920435
105Abnormality of fatty-acid metabolism (HP:0004359)1.93467005
106Hypoplasia of the odontoid process (HP:0003311)1.92592324
107Biconcave vertebral bodies (HP:0004586)1.91966823
108Acute hepatic failure (HP:0006554)1.91808720
109Protuberant abdomen (HP:0001538)1.91805369
110Abnormality of methionine metabolism (HP:0010901)1.91586620
111Ketosis (HP:0001946)1.91460282
112Decreased circulating renin level (HP:0003351)1.91136905
113Abnormality of dental color (HP:0011073)1.90936108
114Insulin resistance (HP:0000855)1.90895693
115Ovoid vertebral bodies (HP:0003300)1.90233004
116Abnormality of the basal ganglia (HP:0002134)1.89525504
117Alopecia of scalp (HP:0002293)1.88637315
118Recurrent abscess formation (HP:0002722)1.88547967
119Abnormality of T cell number (HP:0011839)1.88310416
120Osteomalacia (HP:0002749)1.87830822
121Axonal loss (HP:0003447)1.86697785
122Dysautonomia (HP:0002459)1.86442239
123Epiphyseal stippling (HP:0010655)1.85280873
124Proximal tubulopathy (HP:0000114)1.84912716
125Neuroendocrine neoplasm (HP:0100634)1.84249396
126Abdominal distention (HP:0003270)1.83664365
127Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82926990
128Prominent metopic ridge (HP:0005487)1.82907020
129Aplastic anemia (HP:0001915)1.81742075
130Retinal dysplasia (HP:0007973)1.80404093
131Increased serum lactate (HP:0002151)1.79238971
132Fat malabsorption (HP:0002630)1.79216675
133Nonimmune hydrops fetalis (HP:0001790)1.78781436
134Degeneration of anterior horn cells (HP:0002398)1.76979814
135Abnormality of the anterior horn cell (HP:0006802)1.76979814
136CNS demyelination (HP:0007305)1.75106886
137Soft skin (HP:0000977)1.74831185
138Parakeratosis (HP:0001036)1.74082522
139Palmoplantar hyperkeratosis (HP:0000972)1.73568412
140Onycholysis (HP:0001806)1.72296362
141Mucosal telangiectasiae (HP:0100579)1.70542655
142Prostate neoplasm (HP:0100787)1.70322468
143Delayed CNS myelination (HP:0002188)1.68921572
144Abnormal spermatogenesis (HP:0008669)1.68778901
145Plantar hyperkeratosis (HP:0007556)1.67971337
146Hyperphosphatemia (HP:0002905)1.67619031
147Elevated alkaline phosphatase (HP:0003155)1.66910018
148Abnormality of the vertebral endplates (HP:0005106)1.66888710
149Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.66825782
150* Platyspondyly (HP:0000926)1.66430127
151Conjugated hyperbilirubinemia (HP:0002908)1.65299363
152Petechiae (HP:0000967)1.65258624
153Autoamputation (HP:0001218)1.64868091
154Neoplasm of the adrenal gland (HP:0100631)1.63775723
155Hypoplasia of the uterus (HP:0000013)1.63616699
156Prolonged partial thromboplastin time (HP:0003645)1.63283158
157Episodic fever (HP:0001954)1.62791291
158Hypokalemic alkalosis (HP:0001949)1.62423804
159Congenital ichthyosiform erythroderma (HP:0007431)1.61998971
160Abnormality of alkaline phosphatase activity (HP:0004379)1.61967906
161Abnormality of the fovea (HP:0000493)1.60913857
162Epiphyseal dysplasia (HP:0002656)1.60629662
163Dry hair (HP:0011359)1.60528567
164Abnormality of dicarboxylic acid metabolism (HP:0010995)1.60013239
165Dicarboxylic aciduria (HP:0003215)1.60013239
166Intrahepatic cholestasis (HP:0001406)1.59709043
167Hypoplasia of the fovea (HP:0007750)1.59406668
168Aplasia/Hypoplasia of the fovea (HP:0008060)1.59406668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG4.04803508
2MAPK153.85664609
3INSRR3.70817917
4EIF2AK13.70338245
5MAP3K123.57995078
6PASK3.23648782
7MAP4K23.10239208
8TRIM283.03979823
9IRAK32.50448688
10ERN12.47721197
11PIM22.46075339
12FRK2.40532973
13FLT32.38411319
14WNK42.16125336
15TAOK31.96319808
16EIF2AK31.93843873
17WNK31.80601965
18PBK1.78867333
19BMPR1B1.76021253
20VRK21.73343746
21MET1.72164285
22TESK21.70013215
23IRAK41.68102434
24BCKDK1.65719151
25ACVR1B1.62965721
26MST41.58667291
27HIPK21.58298101
28NME21.55429579
29SIK31.50612831
30NEK11.44227693
31TBK11.44163982
32STK241.39958147
33TESK11.39511147
34TRPM71.37727879
35ERBB31.36886189
36BUB11.30795531
37TGFBR21.27359628
38IRAK11.25144983
39MAP3K141.20406946
40LIMK11.19954314
41JAK31.17269198
42STK161.16839818
43TEC1.15247250
44PDK21.09235920
45GRK11.07617408
46MAP3K31.07186646
47PAK41.04744143
48PLK21.04583000
49ZAP701.03133818
50IKBKB0.98997158
51EPHA30.94821452
52BMPR20.91773893
53STK100.91215413
54IKBKE0.90757030
55NTRK10.90232020
56CAMKK20.89497400
57PLK30.87875409
58GRK70.87342792
59MAP3K20.86870569
60ITK0.86784941
61PLK40.85311825
62SCYL20.85048809
63NEK90.84882748
64SRPK10.84719305
65ADRBK20.84361209
66PRKG20.83899464
67PAK30.83877582
68MAP2K20.83769973
69MAPKAPK50.82038290
70NUAK10.81868952
71STK390.81290519
72BTK0.80547665
73DDR20.80014481
74PDGFRA0.79464233
75MARK30.79399126
76ARAF0.78736522
77TGFBR10.78733664
78CDK80.76953456
79STK30.75416916
80BLK0.75286870
81TYK20.75279055
82PRKD30.73567472
83KIT0.72787208
84TXK0.70902330
85DYRK1B0.70736233
86MOS0.70375618
87EPHA20.70323315
88TIE10.69741674
89MATK0.68855065
90ILK0.66775030
91FER0.66515421
92BRAF0.66401978
93PTK20.66109180
94PTK60.65472912
95EPHB10.65284266
96VRK10.64972148
97NLK0.63516768
98PRPF4B0.62950874
99PRKCI0.62881622
100MYLK0.62042057
101NEK60.61132755
102ZAK0.59939558
103EIF2AK20.59694162
104RPS6KA40.58276683
105JAK10.57962116
106BRSK20.55360932
107CDK30.54768998
108CSNK1G30.54224614
109DAPK10.53715178
110PRKCE0.52993393
111LATS10.52723618
112IGF1R0.52464465
113FGFR30.51753346
114CHUK0.50816704
115DYRK30.50669906
116WNK10.48596301
117WEE10.47759684
118RPS6KA50.47549351
119LYN0.46805319
120MAPKAPK30.46512654
121CSK0.46301447
122MST1R0.45367714
123SIK10.44968330
124ABL20.44430585
125CAMK2D0.43174940
126TAF10.43010331
127CSNK1G10.42303388
128MAPKAPK20.41875588
129CDC42BPA0.41193050
130STK40.40961207
131UHMK10.40910972
132PIK3CA0.39725939
133SYK0.38620383
134TTK0.38044526
135CSF1R0.36719211
136ABL10.36140564
137RPS6KB20.36089195
138PRKCD0.35628886
139AKT30.35408548
140IRAK20.34975553
141BCR0.34772839
142STK38L0.34642045
143FGFR10.33976855
144CSNK2A10.33244970
145FGFR20.32916427
146CSNK2A20.31133367
147PLK10.30535997
148AURKB0.29622890
149FES0.29573001
150PRKD20.29377869

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030607.25790662
2Maturity onset diabetes of the young_Homo sapiens_hsa049506.07604181
3Sulfur metabolism_Homo sapiens_hsa009203.69764436
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.09828638
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28094512
6* Lysosome_Homo sapiens_hsa041422.27446330
7N-Glycan biosynthesis_Homo sapiens_hsa005102.26211125
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.19928705
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08457343
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.01177767
11Vitamin B6 metabolism_Homo sapiens_hsa007502.00529565
12* Other glycan degradation_Homo sapiens_hsa005111.96041867
13Mismatch repair_Homo sapiens_hsa034301.83492283
14Folate biosynthesis_Homo sapiens_hsa007901.81758096
15Vibrio cholerae infection_Homo sapiens_hsa051101.76969817
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71600101
17Steroid biosynthesis_Homo sapiens_hsa001001.61083554
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58687773
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.56269318
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50231457
21Nucleotide excision repair_Homo sapiens_hsa034201.45884453
22Propanoate metabolism_Homo sapiens_hsa006401.41340906
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40433969
24Selenocompound metabolism_Homo sapiens_hsa004501.38623778
25Sphingolipid metabolism_Homo sapiens_hsa006001.37298964
26DNA replication_Homo sapiens_hsa030301.35488610
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31806144
28Base excision repair_Homo sapiens_hsa034101.27801620
29Type I diabetes mellitus_Homo sapiens_hsa049401.27502255
30Basal transcription factors_Homo sapiens_hsa030221.27480747
31Fatty acid elongation_Homo sapiens_hsa000621.23207941
32One carbon pool by folate_Homo sapiens_hsa006701.18578895
33Arachidonic acid metabolism_Homo sapiens_hsa005901.17463903
34Histidine metabolism_Homo sapiens_hsa003401.15232091
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14918270
36Caffeine metabolism_Homo sapiens_hsa002321.13388007
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10976051
38Galactose metabolism_Homo sapiens_hsa000521.09829984
39Fanconi anemia pathway_Homo sapiens_hsa034601.09647026
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09314628
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09131104
42Oxidative phosphorylation_Homo sapiens_hsa001901.08705138
43Homologous recombination_Homo sapiens_hsa034401.08238779
44Legionellosis_Homo sapiens_hsa051341.01405123
45Phagosome_Homo sapiens_hsa041451.00074582
46Primary immunodeficiency_Homo sapiens_hsa053400.99095674
47Peroxisome_Homo sapiens_hsa041460.98615787
48Malaria_Homo sapiens_hsa051440.96849301
49Ribosome_Homo sapiens_hsa030100.96107963
50Staphylococcus aureus infection_Homo sapiens_hsa051500.95994718
51Regulation of autophagy_Homo sapiens_hsa041400.95483332
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94998604
53Linoleic acid metabolism_Homo sapiens_hsa005910.93034236
54RNA polymerase_Homo sapiens_hsa030200.92665797
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91615248
56Starch and sucrose metabolism_Homo sapiens_hsa005000.90692028
57Antigen processing and presentation_Homo sapiens_hsa046120.88988728
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87935540
59Rheumatoid arthritis_Homo sapiens_hsa053230.84860216
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83814533
61RNA degradation_Homo sapiens_hsa030180.82608204
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82510472
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81909433
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79315213
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78143420
66Pyrimidine metabolism_Homo sapiens_hsa002400.77806971
67Insulin secretion_Homo sapiens_hsa049110.77280521
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76778808
69Ether lipid metabolism_Homo sapiens_hsa005650.76397754
70Protein digestion and absorption_Homo sapiens_hsa049740.74991061
71Proteasome_Homo sapiens_hsa030500.73573131
72beta-Alanine metabolism_Homo sapiens_hsa004100.70375918
73Tryptophan metabolism_Homo sapiens_hsa003800.70042987
74Glutathione metabolism_Homo sapiens_hsa004800.68796350
75Parkinsons disease_Homo sapiens_hsa050120.64931550
76Retinol metabolism_Homo sapiens_hsa008300.64631703
77Fatty acid degradation_Homo sapiens_hsa000710.64490551
78ABC transporters_Homo sapiens_hsa020100.64397681
79ECM-receptor interaction_Homo sapiens_hsa045120.61057871
80Allograft rejection_Homo sapiens_hsa053300.60973649
81Arginine and proline metabolism_Homo sapiens_hsa003300.57920999
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.57196448
83Herpes simplex infection_Homo sapiens_hsa051680.56466617
84Alzheimers disease_Homo sapiens_hsa050100.55753846
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.54865586
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52560157
87Pyruvate metabolism_Homo sapiens_hsa006200.52384023
88Metabolic pathways_Homo sapiens_hsa011000.50759389
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50318897
90Fructose and mannose metabolism_Homo sapiens_hsa000510.48929728
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46988858
92Leishmaniasis_Homo sapiens_hsa051400.46661428
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.45435265
94Pertussis_Homo sapiens_hsa051330.45380712
95Chemical carcinogenesis_Homo sapiens_hsa052040.45120900
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45073220
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45013649
98Prion diseases_Homo sapiens_hsa050200.44873185
99Tyrosine metabolism_Homo sapiens_hsa003500.44279388
100Autoimmune thyroid disease_Homo sapiens_hsa053200.41767146
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41676550
102Renin-angiotensin system_Homo sapiens_hsa046140.41565431
103Graft-versus-host disease_Homo sapiens_hsa053320.41279852
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.40347257
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40018956
106Asthma_Homo sapiens_hsa053100.37625252
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37246268
108Fatty acid metabolism_Homo sapiens_hsa012120.36728546
109Phenylalanine metabolism_Homo sapiens_hsa003600.36469718
110Thyroid hormone synthesis_Homo sapiens_hsa049180.33863408
111Measles_Homo sapiens_hsa051620.32650552
112Hematopoietic cell lineage_Homo sapiens_hsa046400.32415362
113Non-homologous end-joining_Homo sapiens_hsa034500.32384469
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30826568
115Sulfur relay system_Homo sapiens_hsa041220.29986067
116Apoptosis_Homo sapiens_hsa042100.28116959
117p53 signaling pathway_Homo sapiens_hsa041150.27403648
118Complement and coagulation cascades_Homo sapiens_hsa046100.26946613
119Butanoate metabolism_Homo sapiens_hsa006500.26867013
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25463205
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24719081
122Pancreatic secretion_Homo sapiens_hsa049720.24616915
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24083010
124TNF signaling pathway_Homo sapiens_hsa046680.22361412
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22237089
126Fat digestion and absorption_Homo sapiens_hsa049750.21551685
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21160873
128Collecting duct acid secretion_Homo sapiens_hsa049660.20075187
129Huntingtons disease_Homo sapiens_hsa050160.19119462

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