ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	9.30111582
2	sperm motility (GO:0030317)	9.06328574
3	fusion of sperm to egg plasma membrane (GO:0007342)	7.44598990
4	response to pheromone (GO:0019236)	7.32605104
5	single strand break repair (GO:0000012)	6.99255409
6	protein polyglutamylation (GO:0018095)	6.79024766
7	spermatid development (GO:0007286)	6.61254490
8	multicellular organism reproduction (GO:0032504)	6.16174472
9	sperm-egg recognition (GO:0035036)	5.91834395
10	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.81962536
11	sperm capacitation (GO:0048240)	5.70470887
12	plasma membrane fusion (GO:0045026)	5.64709046
13	protein targeting to Golgi (GO:0000042)	5.63483562
14	phosphatidylethanolamine metabolic process (GO:0046337)	5.57799133
15	microtubule depolymerization (GO:0007019)	5.52772816
16	establishment of protein localization to Golgi (GO:0072600)	5.41115511
17	calcium ion-dependent exocytosis (GO:0017156)	5.33361027
18	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.22649461
19	reproduction (GO:0000003)	5.21146311
20	binding of sperm to zona pellucida (GO:0007339)	5.17790765
21	regulation of cilium movement (GO:0003352)	5.17523668
22	epithelial cilium movement (GO:0003351)	5.13948357
23	chromosome condensation (GO:0030261)	5.03627478
24	cell-cell recognition (GO:0009988)	5.01018342
25	axonemal dynein complex assembly (GO:0070286)	4.88611735
26	DNA packaging (GO:0006323)	4.87927303
27	RNA destabilization (GO:0050779)	4.69503726
28	microtubule polymerization or depolymerization (GO:0031109)	4.64488205
29	centriole replication (GO:0007099)	4.63559968
30	cellular ketone body metabolic process (GO:0046950)	4.59431322
31	spermatogenesis (GO:0007283)	4.57087066
32	cilium or flagellum-dependent cell motility (GO:0001539)	4.55744438
33	male gamete generation (GO:0048232)	4.55392283
34	regulation of ARF GTPase activity (GO:0032312)	4.53890232
35	spermatid nucleus differentiation (GO:0007289)	4.51073680
36	microtubule severing (GO:0051013)	4.50251982
37	motile cilium assembly (GO:0044458)	4.40389738
38	rRNA methylation (GO:0031167)	4.34546352
39	single fertilization (GO:0007338)	4.32856799
40	protein localization to Golgi apparatus (GO:0034067)	4.28623220
41	centriole assembly (GO:0098534)	4.21399808
42	cilium movement (GO:0003341)	4.18209823
43	gamete generation (GO:0007276)	4.17247725
44	regulation of Rab GTPase activity (GO:0032313)	4.08986507
45	positive regulation of Rab GTPase activity (GO:0032851)	4.08986507
46	ketone body metabolic process (GO:1902224)	3.95347040
47	behavioral response to nicotine (GO:0035095)	3.82511133
48	seminiferous tubule development (GO:0072520)	3.79946744
49	negative regulation of organelle assembly (GO:1902116)	3.75119928
50	organic cation transport (GO:0015695)	3.67679764
51	coenzyme catabolic process (GO:0009109)	3.67197490
52	rRNA modification (GO:0000154)	3.63409570
53	germ cell development (GO:0007281)	3.59519887
54	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.57041613
55	regulation of microtubule-based movement (GO:0060632)	3.53519578
56	regulation of sarcomere organization (GO:0060297)	3.47928158
57	receptor recycling (GO:0001881)	3.43165097
58	fertilization (GO:0009566)	3.41872577
59	chromatin silencing (GO:0006342)	3.41033835
60	regulation of transcription involved in cell fate commitment (GO:0060850)	3.40993521
61	sexual reproduction (GO:0019953)	3.39828826
62	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.23276799
63	axoneme assembly (GO:0035082)	3.22228353
64	ether metabolic process (GO:0018904)	3.20482814
65	multicellular organismal reproductive process (GO:0048609)	3.17786603
66	pyrimidine nucleobase catabolic process (GO:0006208)	3.12918175
67	regulation of action potential (GO:0098900)	3.07340283
68	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.04060943
69	male meiosis (GO:0007140)	3.04036690
70	piRNA metabolic process (GO:0034587)	2.99798568
71	polyamine biosynthetic process (GO:0006596)	2.97605152
72	DNA methylation involved in gamete generation (GO:0043046)	2.95218230
73	cell recognition (GO:0008037)	2.94500260
74	regulation of centriole replication (GO:0046599)	2.93670860
75	negative regulation of Rho protein signal transduction (GO:0035024)	2.92313477
76	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.87746820
77	response to acidic pH (GO:0010447)	2.87175908
78	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.86058321
79	cellular response to pH (GO:0071467)	2.85204526
80	cell wall macromolecule metabolic process (GO:0044036)	2.84704570
81	cell wall macromolecule catabolic process (GO:0016998)	2.83391466
82	spinal cord motor neuron differentiation (GO:0021522)	2.78697940
83	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.77343896
84	microtubule nucleation (GO:0007020)	2.72030508
85	locomotory exploration behavior (GO:0035641)	2.69530282
86	nonmotile primary cilium assembly (GO:0035058)	2.68810573
87	cerebral cortex radially oriented cell migration (GO:0021799)	2.67127671
88	negative regulation of gene expression, epigenetic (GO:0045814)	2.66625848
89	neuronal ion channel clustering (GO:0045161)	2.65744929
90	negative regulation of inclusion body assembly (GO:0090084)	2.64851795
91	microtubule bundle formation (GO:0001578)	2.62355888
92	cilium organization (GO:0044782)	2.62144563
93	cilium assembly (GO:0042384)	2.61694683
94	protein-DNA complex disassembly (GO:0032986)	2.59963198
95	nucleosome disassembly (GO:0006337)	2.59963198
96	parturition (GO:0007567)	2.53081637
97	nucleobase catabolic process (GO:0046113)	2.51966837
98	phenylpropanoid metabolic process (GO:0009698)	2.49625933
99	DNA double-strand break processing (GO:0000729)	2.45150153
100	regulation of cilium assembly (GO:1902017)	2.44614111

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.79969756
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.34679407
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.81105313
4	VDR_22108803_ChIP-Seq_LS180_Human	2.63764741
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.57448490
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.37702779
7	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.35309484
8	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35309484
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.29693471
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.21914105
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.20785882
12	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.18460484
13	FUS_26573619_Chip-Seq_HEK293_Human	2.05681692
14	CBP_20019798_ChIP-Seq_JUKART_Human	2.05274647
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.05274647
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86213026
17	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.84038353
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.82957774
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.79748407
20	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.77305428
21	NANOG_20526341_ChIP-Seq_ESCs_Human	1.75337029
22	RAC3_21632823_ChIP-Seq_H3396_Human	1.69594388
23	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.63771561
24	ERA_21632823_ChIP-Seq_H3396_Human	1.62771346
25	DROSHA_22980978_ChIP-Seq_HELA_Human	1.62008583
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61371241
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.60181046
28	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.59039563
29	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.59033061
30	P300_19829295_ChIP-Seq_ESCs_Human	1.57457833
31	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.56681427
32	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.56305547
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52880972
34	AR_25329375_ChIP-Seq_VCAP_Human	1.52664122
35	MYC_19829295_ChIP-Seq_ESCs_Human	1.51866489
36	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.51385560
37	OCT4_20526341_ChIP-Seq_ESCs_Human	1.48465573
38	TAF2_19829295_ChIP-Seq_ESCs_Human	1.47672141
39	BCL6_27268052_Chip-Seq_Bcells_Human	1.46205263
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.44456400
41	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.43626038
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43071671
43	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.40902923
44	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.40555082
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39389222
46	REST_21632747_ChIP-Seq_MESCs_Mouse	1.39171279
47	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.37580719
48	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.36349721
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.35926272
50	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.32138446
51	PHF8_20622854_ChIP-Seq_HELA_Human	1.32054467
52	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.30810634
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30693483
54	CTCF_27219007_Chip-Seq_Bcells_Human	1.29053382
55	TBL1_22424771_ChIP-Seq_293T_Human	1.26937336
56	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.26247224
57	E2F1_20622854_ChIP-Seq_HELA_Human	1.26181404
58	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26075599
59	NCOR_22424771_ChIP-Seq_293T_Human	1.26032182
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23306524
61	NFYB_21822215_ChIP-Seq_K562_Human	1.22933778
62	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.22198379
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21711585
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21515515
65	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.20232867
66	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19811956
67	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.19226874
68	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.17257989
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16537879
70	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.16510213
71	CTCF_20526341_ChIP-Seq_ESCs_Human	1.16403075
72	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.15733743
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15559984
74	P300_27268052_Chip-Seq_Bcells_Human	1.14931707
75	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.14869445
76	ERG_20517297_ChIP-Seq_VCAP_Human	1.14669966
77	ETV1_20927104_ChIP-Seq_GIST48_Human	1.13525683
78	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13067697
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12071565
80	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.11647900
81	RBPJ_21746931_ChIP-Seq_IB4_Human	1.11351391
82	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.11335285
83	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.10406738
84	STAT3_23295773_ChIP-Seq_U87_Human	1.10279799
85	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.09131854
86	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08637746
87	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08637746
88	P53_21459846_ChIP-Seq_SAOS-2_Human	1.07563167
89	AR_21572438_ChIP-Seq_LNCaP_Human	1.07380668
90	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.07356122
91	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06878847
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06578442
93	PHF8_20622853_ChIP-Seq_HELA_Human	1.05996571
94	NFYA_21822215_ChIP-Seq_K562_Human	1.05295709
95	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.05178469
96	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03553166
97	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.02850870
98	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.01272636
99	SMC4_20622854_ChIP-Seq_HELA_Human	1.00254372
100	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.99874311

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.11974809
2	MP0006292_abnormal_olfactory_placode	3.59919920
3	MP0008789_abnormal_olfactory_epithelium	3.22670779
4	MP0003878_abnormal_ear_physiology	2.95660009
5	MP0005377_hearing/vestibular/ear_phenot	2.95660009
6	MP0003698_abnormal_male_reproductive	2.94291399
7	MP0005394_taste/olfaction_phenotype	2.85514308
8	MP0005499_abnormal_olfactory_system	2.85514308
9	MP0001929_abnormal_gametogenesis	2.57654353
10	MP0005670_abnormal_white_adipose	2.37936345
11	MP0002102_abnormal_ear_morphology	2.34355438
12	MP0001485_abnormal_pinna_reflex	2.28602850
13	MP0001529_abnormal_vocalization	2.13594246
14	MP0003011_delayed_dark_adaptation	1.99475253
15	MP0004859_abnormal_synaptic_plasticity	1.91768167
16	MP0003880_abnormal_central_pattern	1.90781487
17	MP0001984_abnormal_olfaction	1.86810477
18	MP0001348_abnormal_lacrimal_gland	1.81678074
19	MP0001486_abnormal_startle_reflex	1.80217175
20	MP0004742_abnormal_vestibular_system	1.79715228
21	MP0005551_abnormal_eye_electrophysiolog	1.76707224
22	MP0000049_abnormal_middle_ear	1.68057616
23	MP0005379_endocrine/exocrine_gland_phen	1.67437539
24	MP0008877_abnormal_DNA_methylation	1.66018043
25	MP0005423_abnormal_somatic_nervous	1.64845362
26	MP0001968_abnormal_touch/_nociception	1.62705990
27	MP0003718_maternal_effect	1.61800060
28	MP0003950_abnormal_plasma_membrane	1.58161992
29	MP0002822_catalepsy	1.56813048
30	MP0002161_abnormal_fertility/fecundity	1.55717862
31	MP0008995_early_reproductive_senescence	1.54121616
32	MP0006276_abnormal_autonomic_nervous	1.47998977
33	MP0002653_abnormal_ependyma_morphology	1.46665064
34	MP0003646_muscle_fatigue	1.44717261
35	MP0002210_abnormal_sex_determination	1.44375137
36	MP0000678_abnormal_parathyroid_gland	1.43232241
37	MP0003787_abnormal_imprinting	1.38441425
38	MP0000955_abnormal_spinal_cord	1.37016635
39	MP0002272_abnormal_nervous_system	1.31447051
40	MP0002557_abnormal_social/conspecific_i	1.31353531
41	MP0002733_abnormal_thermal_nociception	1.27233259
42	MP0005253_abnormal_eye_physiology	1.25318837
43	MP0000026_abnormal_inner_ear	1.24854755
44	MP0000749_muscle_degeneration	1.16770487
45	MP0002234_abnormal_pharynx_morphology	1.16096021
46	MP0001145_abnormal_male_reproductive	1.15805860
47	MP0001270_distended_abdomen	1.12174804
48	MP0002067_abnormal_sensory_capabilities	1.12095136
49	MP0001963_abnormal_hearing_physiology	1.12053679
50	MP0002127_abnormal_cardiovascular_syste	1.11351175
51	MP0002735_abnormal_chemical_nociception	1.09571648
52	MP0002132_abnormal_respiratory_system	1.08599346
53	MP0003938_abnormal_ear_development	1.08363198
54	MP0008775_abnormal_heart_ventricle	1.08099313
55	MP0002229_neurodegeneration	1.07658408
56	MP0000653_abnormal_sex_gland	1.07285887
57	MP0002184_abnormal_innervation	1.05097308
58	MP0004142_abnormal_muscle_tone	1.03816616
59	MP0002572_abnormal_emotion/affect_behav	1.02271214
60	MP0001970_abnormal_pain_threshold	0.99773834
61	MP0002160_abnormal_reproductive_system	0.99544649
62	MP0008004_abnormal_stomach_pH	0.98739901
63	MP0005645_abnormal_hypothalamus_physiol	0.96700793
64	MP0002736_abnormal_nociception_after	0.96198612
65	MP0009046_muscle_twitch	0.95300291
66	MP0006072_abnormal_retinal_apoptosis	0.95163463
67	MP0002282_abnormal_trachea_morphology	0.93624515
68	MP0002752_abnormal_somatic_nervous	0.92548784
69	MP0003635_abnormal_synaptic_transmissio	0.92487050
70	MP0001905_abnormal_dopamine_level	0.92435384
71	MP0002837_dystrophic_cardiac_calcinosis	0.91832064
72	MP0009745_abnormal_behavioral_response	0.90637178
73	MP0004084_abnormal_cardiac_muscle	0.89508161
74	MP0004270_analgesia	0.87272322
75	MP0005083_abnormal_biliary_tract	0.87229624
76	MP0002249_abnormal_larynx_morphology	0.86788392
77	MP0000778_abnormal_nervous_system	0.84737069
78	MP0005084_abnormal_gallbladder_morpholo	0.84413860
79	MP0001986_abnormal_taste_sensitivity	0.83172908
80	MP0003879_abnormal_hair_cell	0.83051048
81	MP0005248_abnormal_Harderian_gland	0.82166720
82	MP0002882_abnormal_neuron_morphology	0.80907558
83	MP0001501_abnormal_sleep_pattern	0.79520077
84	MP0005646_abnormal_pituitary_gland	0.78170354
85	MP0005391_vision/eye_phenotype	0.72003309
86	MP0008872_abnormal_physiological_respon	0.71259297
87	MP0000230_abnormal_systemic_arterial	0.71231052
88	MP0003122_maternal_imprinting	0.68485773
89	MP0002063_abnormal_learning/memory/cond	0.68129717
90	MP0001188_hyperpigmentation	0.65136084
91	MP0005389_reproductive_system_phenotype	0.64508760
92	MP0005332_abnormal_amino_acid	0.64070387
93	MP0001765_abnormal_ion_homeostasis	0.63543180
94	MP0001764_abnormal_homeostasis	0.63108954
95	MP0001293_anophthalmia	0.60214701
96	MP0009115_abnormal_fat_cell	0.59230235
97	MP0004085_abnormal_heartbeat	0.57759955
98	MP0004811_abnormal_neuron_physiology	0.57599566
99	MP0002734_abnormal_mechanical_nocicepti	0.57574475
100	MP0002269_muscular_atrophy	0.57319504

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	4.77078407
2	Severe visual impairment (HP:0001141)	4.65246462
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.61143967
4	Absent/shortened dynein arms (HP:0200106)	4.61143967
5	Asymmetric septal hypertrophy (HP:0001670)	4.45438840
6	Tubulointerstitial nephritis (HP:0001970)	4.33802751
7	Attenuation of retinal blood vessels (HP:0007843)	4.09781839
8	Bony spicule pigmentary retinopathy (HP:0007737)	4.07171457
9	Abnormal rod and cone electroretinograms (HP:0008323)	3.87954207
10	Hypoplasia of the thymus (HP:0000778)	3.84135706
11	Abnormal ciliary motility (HP:0012262)	3.75758045
12	Abnormal respiratory motile cilium physiology (HP:0012261)	3.45308603
13	Abnormal respiratory motile cilium morphology (HP:0005938)	3.39856953
14	Abnormal respiratory epithelium morphology (HP:0012253)	3.39856953
15	Retinal dysplasia (HP:0007973)	3.23870708
16	Resting tremor (HP:0002322)	3.20746371
17	Hand muscle atrophy (HP:0009130)	3.13759820
18	Nephronophthisis (HP:0000090)	3.11895123
19	Infertility (HP:0000789)	2.87271675
20	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.83324954
21	Male infertility (HP:0003251)	2.82376410
22	Calf muscle hypertrophy (HP:0008981)	2.81569239
23	Impulsivity (HP:0100710)	2.71108956
24	Progressive cerebellar ataxia (HP:0002073)	2.64230045
25	Abnormality of macular pigmentation (HP:0008002)	2.63687255
26	Muscle hypertrophy of the lower extremities (HP:0008968)	2.62794307
27	Exercise-induced myalgia (HP:0003738)	2.59032563
28	Abnormality of the renal medulla (HP:0100957)	2.58662223
29	Medial flaring of the eyebrow (HP:0010747)	2.58176912
30	Polydipsia (HP:0001959)	2.53944668
31	Abnormal drinking behavior (HP:0030082)	2.53944668
32	Molar tooth sign on MRI (HP:0002419)	2.52069518
33	Abnormality of midbrain morphology (HP:0002418)	2.52069518
34	Hyperkalemia (HP:0002153)	2.51746596
35	Failure to thrive in infancy (HP:0001531)	2.47107288
36	Upper limb muscle weakness (HP:0003484)	2.39800351
37	Myokymia (HP:0002411)	2.36531799
38	Type 2 muscle fiber atrophy (HP:0003554)	2.35564949
39	Poor suck (HP:0002033)	2.35016098
40	True hermaphroditism (HP:0010459)	2.33879628
41	Type II lissencephaly (HP:0007260)	2.31443080
42	Exercise-induced muscle cramps (HP:0003710)	2.30828474
43	Flat capital femoral epiphysis (HP:0003370)	2.29650991
44	Disproportionate short-trunk short stature (HP:0003521)	2.25620245
45	Pancreatic cysts (HP:0001737)	2.25081224
46	Postural instability (HP:0002172)	2.24933076
47	Keratoconus (HP:0000563)	2.23387805
48	Increased corneal curvature (HP:0100692)	2.23387805
49	Abnormality of dental color (HP:0011073)	2.22894739
50	Abnormality of the aortic arch (HP:0012303)	2.20020105
51	Optic nerve hypoplasia (HP:0000609)	2.18288952
52	Hypoplastic ischia (HP:0003175)	2.17401213
53	Tubulointerstitial abnormality (HP:0001969)	2.16165953
54	Muscle fiber atrophy (HP:0100295)	2.15279631
55	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.13712013
56	Inability to walk (HP:0002540)	2.11330631
57	Pendular nystagmus (HP:0012043)	2.10897603
58	Abnormal urine output (HP:0012590)	2.10221510
59	Growth hormone deficiency (HP:0000824)	2.10184929
60	Upper limb amyotrophy (HP:0009129)	2.08585077
61	Distal upper limb amyotrophy (HP:0007149)	2.08585077
62	Pancreatic fibrosis (HP:0100732)	2.07217157
63	Gait imbalance (HP:0002141)	2.07052073
64	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.06622212
65	Renal dysplasia (HP:0000110)	2.05470143
66	Polyuria (HP:0000103)	2.05455725
67	Myotonia (HP:0002486)	2.04591455
68	Cerebellar dysplasia (HP:0007033)	2.02940785
69	Osteomalacia (HP:0002749)	2.02782650
70	Abnormality of the renal cortex (HP:0011035)	2.02542114
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.02354555
72	Abolished electroretinogram (ERG) (HP:0000550)	2.02345186
73	Congenital primary aphakia (HP:0007707)	2.01506718
74	Cone-rod dystrophy (HP:0000548)	2.01218726
75	Occipital encephalocele (HP:0002085)	1.99167302
76	Congenital malformation of the right heart (HP:0011723)	1.98175631
77	Double outlet right ventricle (HP:0001719)	1.98175631
78	Flattened epiphyses (HP:0003071)	1.97894585
79	Polyphagia (HP:0002591)	1.96844267
80	Enlarged epiphyses (HP:0010580)	1.96532367
81	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.94313063
82	Hyperglycinemia (HP:0002154)	1.92076100
83	Intellectual disability, moderate (HP:0002342)	1.91309493
84	Hypophosphatemic rickets (HP:0004912)	1.89864485
85	Abnormality of renal excretion (HP:0011036)	1.88550416
86	Stage 5 chronic kidney disease (HP:0003774)	1.88255039
87	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.84466553
88	Abnormality of the femoral head (HP:0003368)	1.84214290
89	Poor coordination (HP:0002370)	1.84182362
90	Nephrogenic diabetes insipidus (HP:0009806)	1.84066805
91	Tubular atrophy (HP:0000092)	1.83745367
92	Facial shape deformation (HP:0011334)	1.83163731
93	Potter facies (HP:0002009)	1.83163731
94	Sclerocornea (HP:0000647)	1.82807302
95	Prolonged QT interval (HP:0001657)	1.82482118
96	Hypoplasia of the brainstem (HP:0002365)	1.82385217
97	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.82385217
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81046777
99	Abnormality of the vertebral endplates (HP:0005106)	1.80654572
100	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.79921492

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	5.77195668
2	MAP4K2	4.97947060
3	PINK1	3.18076676
4	INSRR	2.66805913
5	PRKD3	2.63309276
6	PLK2	2.35224761
7	MAPKAPK5	2.25280759
8	MAP2K7	2.19035898
9	TESK1	2.04111377
10	BMPR1B	1.99433982
11	DDR2	1.84369347
12	PIK3CG	1.81716560
13	STK38	1.70413884
14	ADRBK2	1.68428939
15	BCKDK	1.68230979
16	MAPK13	1.66410425
17	PNCK	1.64662546
18	MAP3K4	1.58448671
19	CASK	1.54441068
20	STK38L	1.53515532
21	DYRK2	1.39247098
22	SIK2	1.38324624
23	BRD4	1.33200637
24	WNK4	1.32449603
25	CDK19	1.30209529
26	CAMK1G	1.30050966
27	FRK	1.26731855
28	NTRK3	1.24452341
29	STK16	1.24021703
30	MAP3K9	1.22756603
31	EPHA4	1.22504210
32	CDK8	1.20714806
33	MUSK	1.20338024
34	DYRK1B	1.17174989
35	CSNK1G3	1.14797656
36	CSNK1A1L	1.14747700
37	MAPK15	1.11587332
38	WNK3	1.07804745
39	RPS6KA2	1.04371422
40	DYRK3	1.03516284
41	CSNK1G2	1.00276504
42	PDK1	0.91574269
43	DAPK2	0.90351770
44	PRKCG	0.90167191
45	ZAK	0.88476993
46	MARK3	0.86007087
47	MARK1	0.83601870
48	PTK2B	0.80071374
49	CCNB1	0.79825123
50	NEK6	0.78394279
51	NUAK1	0.78261057
52	CSNK1G1	0.77556048
53	NTRK2	0.73454037
54	GRK1	0.72249609
55	MET	0.71951505
56	WNK1	0.71924663
57	PDPK1	0.70478021
58	MAP3K7	0.66403972
59	MAP2K2	0.64450125
60	MST1R	0.64438086
61	PRKAA2	0.64280749
62	PHKG1	0.61689581
63	PHKG2	0.61689581
64	PKN1	0.61023356
65	CDK7	0.59397418
66	PAK3	0.57814999
67	CDK3	0.56890954
68	PRKG1	0.56692353
69	PRKAA1	0.56619523
70	TXK	0.54575187
71	EEF2K	0.54172634
72	NEK2	0.53063818
73	RPS6KA1	0.51996420
74	OBSCN	0.51916126
75	PRKCZ	0.51871905
76	PRKACB	0.48991176
77	SGK494	0.47300673
78	SGK223	0.47300673
79	CAMK1	0.47093006
80	PRKCQ	0.46530163
81	MAPKAPK3	0.45692668
82	TYRO3	0.45510503
83	TESK2	0.45381927
84	TNIK	0.43198424
85	CSNK1D	0.42511355
86	TIE1	0.41798654
87	PRKG2	0.40168578
88	CSNK1A1	0.38200303
89	RPS6KA5	0.37525040
90	PRKACA	0.36547550
91	STK39	0.35450917
92	IKBKB	0.35248560
93	OXSR1	0.34868118
94	TLK1	0.34271053
95	TRIM28	0.33617523
96	PRKCE	0.32619872
97	EPHB2	0.31797454
98	VRK1	0.31276856
99	MARK2	0.31234639
100	RPS6KA6	0.30090260

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.57479161
2	Olfactory transduction_Homo sapiens_hsa04740	3.48378179
3	Butanoate metabolism_Homo sapiens_hsa00650	3.20721171
4	Phototransduction_Homo sapiens_hsa04744	2.26713967
5	Regulation of autophagy_Homo sapiens_hsa04140	2.06250608
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.02925920
7	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.93916689
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.93733036
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.92211849
10	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.86086891
11	Propanoate metabolism_Homo sapiens_hsa00640	1.78468192
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.73242744
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.72978894
14	Nicotine addiction_Homo sapiens_hsa05033	1.69714938
15	Taste transduction_Homo sapiens_hsa04742	1.63711353
16	Fatty acid degradation_Homo sapiens_hsa00071	1.59738551
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57958184
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56665333
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.49074779
20	Glycerolipid metabolism_Homo sapiens_hsa00561	1.36212408
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.35214888
22	Basal transcription factors_Homo sapiens_hsa03022	1.34738311
23	Fatty acid metabolism_Homo sapiens_hsa01212	1.33608594
24	Peroxisome_Homo sapiens_hsa04146	1.33294895
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.33266242
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.32547911
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.23377164
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.21912144
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.18994893
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.17903583
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17814681
32	Sulfur relay system_Homo sapiens_hsa04122	1.13865807
33	Morphine addiction_Homo sapiens_hsa05032	1.12404546
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.09520517
35	Circadian entrainment_Homo sapiens_hsa04713	1.09291298
36	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.09124762
37	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.06463282
38	Arginine and proline metabolism_Homo sapiens_hsa00330	1.04759016
39	GABAergic synapse_Homo sapiens_hsa04727	1.03890374
40	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.02604190
41	Fat digestion and absorption_Homo sapiens_hsa04975	1.02049311
42	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.01128952
43	Collecting duct acid secretion_Homo sapiens_hsa04966	0.96664296
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95052985
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.94273187
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.94207596
47	Insulin secretion_Homo sapiens_hsa04911	0.94095044
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.91404391
49	Retinol metabolism_Homo sapiens_hsa00830	0.90496637
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.89226082
51	Oxidative phosphorylation_Homo sapiens_hsa00190	0.88931852
52	Oocyte meiosis_Homo sapiens_hsa04114	0.88537593
53	Parkinsons disease_Homo sapiens_hsa05012	0.88007835
54	ABC transporters_Homo sapiens_hsa02010	0.87880341
55	Type II diabetes mellitus_Homo sapiens_hsa04930	0.86731984
56	Huntingtons disease_Homo sapiens_hsa05016	0.84693353
57	Phenylalanine metabolism_Homo sapiens_hsa00360	0.82845772
58	Salivary secretion_Homo sapiens_hsa04970	0.81041862
59	Base excision repair_Homo sapiens_hsa03410	0.77942312
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.77340027
61	RNA transport_Homo sapiens_hsa03013	0.77078335
62	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.76832734
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.75476972
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.74492816
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.72557808
66	Lysine degradation_Homo sapiens_hsa00310	0.70785113
67	Purine metabolism_Homo sapiens_hsa00230	0.69820225
68	Cholinergic synapse_Homo sapiens_hsa04725	0.63799792
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63572033
70	Renin secretion_Homo sapiens_hsa04924	0.63301291
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.62660012
72	Serotonergic synapse_Homo sapiens_hsa04726	0.61317040
73	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59848072
74	Metabolic pathways_Homo sapiens_hsa01100	0.59220641
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57868332
76	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.57468038
77	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.55140623
78	Pyruvate metabolism_Homo sapiens_hsa00620	0.53744798
79	RNA degradation_Homo sapiens_hsa03018	0.53079863
80	Endocytosis_Homo sapiens_hsa04144	0.52728439
81	Amphetamine addiction_Homo sapiens_hsa05031	0.51493182
82	Long-term depression_Homo sapiens_hsa04730	0.50050737
83	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.48839949
84	Gastric acid secretion_Homo sapiens_hsa04971	0.48067521
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.45911044
86	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.43581869
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.42908819
88	Phagosome_Homo sapiens_hsa04145	0.41364895
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.39127688
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38887543
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36018335
92	Pancreatic secretion_Homo sapiens_hsa04972	0.35961954
93	Cocaine addiction_Homo sapiens_hsa05030	0.34812596
94	Axon guidance_Homo sapiens_hsa04360	0.33073138
95	Arginine biosynthesis_Homo sapiens_hsa00220	0.32961110
96	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.30882156
97	Gap junction_Homo sapiens_hsa04540	0.30781661
98	Viral myocarditis_Homo sapiens_hsa05416	0.30736854
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.30420050
100	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29501906

AGAP10P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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