ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.15348289
2	axonemal dynein complex assembly (GO:0070286)	6.08328668
3	epithelial cilium movement (GO:0003351)	5.87750636
4	cilium movement (GO:0003341)	5.34050218
5	cilium or flagellum-dependent cell motility (GO:0001539)	5.00158553
6	regulation of cilium movement (GO:0003352)	4.77741018
7	motile cilium assembly (GO:0044458)	4.19238313
8	response to pheromone (GO:0019236)	4.18309988
9	sperm motility (GO:0030317)	4.08870569
10	acrosome reaction (GO:0007340)	3.88298257
11	axoneme assembly (GO:0035082)	3.79806624
12	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.75518588
13	substrate-independent telencephalic tangential migration (GO:0021826)	3.75518588
14	regulation of microtubule-based movement (GO:0060632)	3.65554129
15	behavioral response to nicotine (GO:0035095)	3.62960504
16	pyrimidine nucleobase catabolic process (GO:0006208)	3.57949546
17	cell proliferation in forebrain (GO:0021846)	3.56735212
18	intraciliary transport (GO:0042073)	3.55178909
19	centriole replication (GO:0007099)	3.38753308
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.38065415
21	cilium organization (GO:0044782)	3.35748931
22	cilium assembly (GO:0042384)	3.32092512
23	sex differentiation (GO:0007548)	3.27862555
24	cellular ketone body metabolic process (GO:0046950)	3.27174954
25	somite development (GO:0061053)	3.19947114
26	establishment of protein localization to Golgi (GO:0072600)	3.16150806
27	nonmotile primary cilium assembly (GO:0035058)	3.16146017
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.15165700
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.15165700
30	NADH dehydrogenase complex assembly (GO:0010257)	3.15165700
31	protein polyglutamylation (GO:0018095)	3.14096428
32	seminiferous tubule development (GO:0072520)	3.13726295
33	spermatid development (GO:0007286)	3.12711395
34	auditory behavior (GO:0031223)	3.08677357
35	multicellular organism reproduction (GO:0032504)	3.02646454
36	protein complex biogenesis (GO:0070271)	2.98831962
37	centriole assembly (GO:0098534)	2.97779051
38	nucleobase catabolic process (GO:0046113)	2.93434896
39	protein targeting to Golgi (GO:0000042)	2.93321331
40	ventricular system development (GO:0021591)	2.91302378
41	single strand break repair (GO:0000012)	2.91082266
42	regulation of action potential (GO:0098900)	2.87342312
43	male meiosis I (GO:0007141)	2.87219343
44	cilium morphogenesis (GO:0060271)	2.83530149
45	ketone body metabolic process (GO:1902224)	2.83073098
46	axon ensheathment in central nervous system (GO:0032291)	2.79316814
47	central nervous system myelination (GO:0022010)	2.79316814
48	indole-containing compound catabolic process (GO:0042436)	2.76777745
49	indolalkylamine catabolic process (GO:0046218)	2.76777745
50	tryptophan catabolic process (GO:0006569)	2.76777745
51	negative regulation of multicellular organism growth (GO:0040015)	2.73207531
52	piRNA metabolic process (GO:0034587)	2.72811042
53	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.72253493
54	left/right axis specification (GO:0070986)	2.70775498
55	male meiosis (GO:0007140)	2.70735000
56	photoreceptor cell maintenance (GO:0045494)	2.70697131
57	behavioral response to ethanol (GO:0048149)	2.70626583
58	microtubule depolymerization (GO:0007019)	2.69837928
59	protein localization to Golgi apparatus (GO:0034067)	2.69492682
60	positive regulation of gastrulation (GO:2000543)	2.68214176
61	synapsis (GO:0007129)	2.68189926
62	mitochondrial respiratory chain complex assembly (GO:0033108)	2.67905394
63	limb development (GO:0060173)	2.67312173
64	appendage development (GO:0048736)	2.67312173
65	mechanosensory behavior (GO:0007638)	2.66295142
66	hindbrain development (GO:0030902)	2.64929288
67	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.64426367
68	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.64036582
69	pattern specification involved in kidney development (GO:0061004)	2.63460782
70	cellular component assembly involved in morphogenesis (GO:0010927)	2.61215949
71	DNA methylation involved in gamete generation (GO:0043046)	2.60688623
72	ATP synthesis coupled proton transport (GO:0015986)	2.55899738
73	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.55899738
74	dendritic spine morphogenesis (GO:0060997)	2.54920413
75	synaptic transmission, cholinergic (GO:0007271)	2.53566469
76	regulation of collateral sprouting (GO:0048670)	2.52860633
77	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.52227177
78	peristalsis (GO:0030432)	2.51315689
79	cerebral cortex radially oriented cell migration (GO:0021799)	2.47192029
80	potassium ion export (GO:0071435)	2.47103326
81	smoothened signaling pathway (GO:0007224)	2.46173517
82	sperm-egg recognition (GO:0035036)	2.45984281
83	thalamus development (GO:0021794)	2.45670744
84	spinal cord motor neuron differentiation (GO:0021522)	2.43591129
85	presynaptic membrane organization (GO:0097090)	2.43440995
86	calcium ion-dependent exocytosis (GO:0017156)	2.43421679
87	left/right pattern formation (GO:0060972)	2.43073994
88	resolution of meiotic recombination intermediates (GO:0000712)	2.42913676
89	indolalkylamine metabolic process (GO:0006586)	2.42846368
90	somite rostral/caudal axis specification (GO:0032525)	2.42619379
91	fucose catabolic process (GO:0019317)	2.40348156
92	L-fucose metabolic process (GO:0042354)	2.40348156
93	L-fucose catabolic process (GO:0042355)	2.40348156
94	protein localization to cilium (GO:0061512)	2.39758232
95	microtubule bundle formation (GO:0001578)	2.38113141
96	neuronal action potential (GO:0019228)	2.38003641
97	amine catabolic process (GO:0009310)	2.36487634
98	cellular biogenic amine catabolic process (GO:0042402)	2.36487634
99	presynaptic membrane assembly (GO:0097105)	2.34917831
100	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.34766721

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.09128712
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68567203
3	VDR_22108803_ChIP-Seq_LS180_Human	3.36063478
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.87667395
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.53803834
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.50591455
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.48936343
8	FUS_26573619_Chip-Seq_HEK293_Human	2.33847944
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.32965923
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30551794
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.24735005
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.19671017
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.11641881
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.99927880
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.98088744
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.95926672
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.93232098
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.80832048
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.78957591
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.78449707
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72581008
22	P300_19829295_ChIP-Seq_ESCs_Human	1.71423444
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.68569836
24	EWS_26573619_Chip-Seq_HEK293_Human	1.61662358
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.57809318
26	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55647818
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55647818
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54985422
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.49107921
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.48923310
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.48198961
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.47335749
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.47324374
34	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.43599718
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42968513
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.42968513
37	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.41301364
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41281032
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.40953454
40	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.40551897
41	AR_25329375_ChIP-Seq_VCAP_Human	1.38861853
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37555528
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34980365
44	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.32089184
45	DROSHA_22980978_ChIP-Seq_HELA_Human	1.31732601
46	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.31489837
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31033524
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.30903244
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29763601
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26658572
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24250876
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24078290
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22844570
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22085767
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.20787060
56	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.20552155
57	MYC_19829295_ChIP-Seq_ESCs_Human	1.19376650
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17323306
59	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.16884768
60	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.16434848
61	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15813664
62	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.14570557
63	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.14149346
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.13291720
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13136635
66	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.11114667
67	NCOR_22424771_ChIP-Seq_293T_Human	1.11100444
68	ERA_21632823_ChIP-Seq_H3396_Human	1.10032275
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.09346101
70	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.07178925
71	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.07075088
72	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.07075088
73	STAT3_23295773_ChIP-Seq_U87_Human	1.06618080
74	AR_21572438_ChIP-Seq_LNCaP_Human	1.06167807
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06164912
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.05949134
77	TCF4_23295773_ChIP-Seq_U87_Human	1.05849403
78	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.05718761
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04978269
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04978269
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04271027
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04271027
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02844121
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02228310
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02135311
86	TBL1_22424771_ChIP-Seq_293T_Human	1.01829070
87	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01710984
88	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.01681603
89	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.01576360
90	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.01336773
91	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.00131087
92	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.99906212
93	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98711023
94	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98671317
95	TAF2_19829295_ChIP-Seq_ESCs_Human	0.98460023
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98380441
97	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.98142575
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97295988
99	ETV1_20927104_ChIP-Seq_GIST48_Human	0.97214118
100	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.95910257

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.94567106
2	MP0002822_catalepsy	3.59702294
3	MP0002653_abnormal_ependyma_morphology	2.83958981
4	MP0008789_abnormal_olfactory_epithelium	2.43183707
5	MP0005394_taste/olfaction_phenotype	2.38781922
6	MP0005499_abnormal_olfactory_system	2.38781922
7	MP0003787_abnormal_imprinting	2.35857525
8	MP0003136_yellow_coat_color	2.32665216
9	MP0005410_abnormal_fertilization	2.30700865
10	MP0008877_abnormal_DNA_methylation	2.26342420
11	MP0009379_abnormal_foot_pigmentation	2.11523581
12	MP0005377_hearing/vestibular/ear_phenot	2.10151886
13	MP0003878_abnormal_ear_physiology	2.10151886
14	MP0001485_abnormal_pinna_reflex	2.09421198
15	MP0003880_abnormal_central_pattern	2.08327613
16	MP0001188_hyperpigmentation	2.06291348
17	MP0001529_abnormal_vocalization	2.03138993
18	MP0008995_early_reproductive_senescence	1.98047537
19	MP0002837_dystrophic_cardiac_calcinosis	1.82832907
20	MP0003011_delayed_dark_adaptation	1.80163367
21	MP0005551_abnormal_eye_electrophysiolog	1.72807043
22	MP0005646_abnormal_pituitary_gland	1.72617710
23	MP0001486_abnormal_startle_reflex	1.71317189
24	MP0006072_abnormal_retinal_apoptosis	1.66608478
25	MP0002102_abnormal_ear_morphology	1.64646495
26	MP0002234_abnormal_pharynx_morphology	1.63887695
27	MP0000778_abnormal_nervous_system	1.59455598
28	MP0009745_abnormal_behavioral_response	1.57823911
29	MP0004142_abnormal_muscle_tone	1.54590596
30	MP0002938_white_spotting	1.54404880
31	MP0003698_abnormal_male_reproductive	1.54283347
32	MP0004133_heterotaxia	1.51177512
33	MP0000631_abnormal_neuroendocrine_gland	1.51031775
34	MP0002272_abnormal_nervous_system	1.44766098
35	MP0000569_abnormal_digit_pigmentation	1.43674245
36	MP0001293_anophthalmia	1.42983351
37	MP0003938_abnormal_ear_development	1.42323601
38	MP0000049_abnormal_middle_ear	1.40982747
39	MP0005174_abnormal_tail_pigmentation	1.38907400
40	MP0004742_abnormal_vestibular_system	1.38353131
41	MP0002557_abnormal_social/conspecific_i	1.37680199
42	MP0001968_abnormal_touch/_nociception	1.37195675
43	MP0001984_abnormal_olfaction	1.33878425
44	MP0001929_abnormal_gametogenesis	1.32153196
45	MP0004885_abnormal_endolymph	1.31416296
46	MP0000026_abnormal_inner_ear	1.30977656
47	MP0002277_abnormal_respiratory_mucosa	1.26836926
48	MP0000566_synostosis	1.26717443
49	MP0005253_abnormal_eye_physiology	1.24358145
50	MP0005379_endocrine/exocrine_gland_phen	1.23872906
51	MP0009046_muscle_twitch	1.23122848
52	MP0002210_abnormal_sex_determination	1.23008045
53	MP0005423_abnormal_somatic_nervous	1.21389861
54	MP0002572_abnormal_emotion/affect_behav	1.20179982
55	MP0002909_abnormal_adrenal_gland	1.19716192
56	MP0002160_abnormal_reproductive_system	1.18598179
57	MP0004147_increased_porphyrin_level	1.15202904
58	MP0002184_abnormal_innervation	1.11958034
59	MP0002735_abnormal_chemical_nociception	1.11419245
60	MP0005084_abnormal_gallbladder_morpholo	1.11116190
61	MP0000955_abnormal_spinal_cord	1.10530284
62	MP0003635_abnormal_synaptic_transmissio	1.09950628
63	MP0003119_abnormal_digestive_system	1.09684089
64	MP0002064_seizures	1.09469247
65	MP0003195_calcinosis	1.07761392
66	MP0003646_muscle_fatigue	1.06992779
67	MP0002736_abnormal_nociception_after	1.06498300
68	MP0003890_abnormal_embryonic-extraembry	1.06334042
69	MP0002752_abnormal_somatic_nervous	1.05123022
70	MP0003121_genomic_imprinting	1.03854699
71	MP0001963_abnormal_hearing_physiology	1.01908201
72	MP0002067_abnormal_sensory_capabilities	1.00586097
73	MP0002733_abnormal_thermal_nociception	1.00184635
74	MP0001145_abnormal_male_reproductive	0.99800963
75	MP0002163_abnormal_gland_morphology	0.98674638
76	MP0001502_abnormal_circadian_rhythm	0.96915079
77	MP0001970_abnormal_pain_threshold	0.95801172
78	MP0003315_abnormal_perineum_morphology	0.95396046
79	MP0000653_abnormal_sex_gland	0.95320705
80	MP0002063_abnormal_learning/memory/cond	0.95243580
81	MP0002233_abnormal_nose_morphology	0.94433882
82	MP0006276_abnormal_autonomic_nervous	0.94317165
83	MP0001905_abnormal_dopamine_level	0.94067851
84	MP0002882_abnormal_neuron_morphology	0.93169253
85	MP0003718_maternal_effect	0.92919372
86	MP0000427_abnormal_hair_cycle	0.91873024
87	MP0004043_abnormal_pH_regulation	0.91823761
88	MP0002638_abnormal_pupillary_reflex	0.91556549
89	MP0002161_abnormal_fertility/fecundity	0.89632153
90	MP0004145_abnormal_muscle_electrophysio	0.88899599
91	MP0002095_abnormal_skin_pigmentation	0.85304950
92	MP0005195_abnormal_posterior_eye	0.83292366
93	MP0002282_abnormal_trachea_morphology	0.82805852
94	MP0005386_behavior/neurological_phenoty	0.82307900
95	MP0004924_abnormal_behavior	0.82307900
96	MP0003879_abnormal_hair_cell	0.82153175
97	MP0001986_abnormal_taste_sensitivity	0.81951365
98	MP0001286_abnormal_eye_development	0.81611789
99	MP0005391_vision/eye_phenotype	0.81047469
100	MP0001299_abnormal_eye_distance/	0.80671260

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	4.75722831
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.75722831
3	Abnormal respiratory motile cilium morphology (HP:0005938)	4.75355183
4	Abnormal respiratory epithelium morphology (HP:0012253)	4.75355183
5	Abnormal ciliary motility (HP:0012262)	4.28758210
6	Abnormal respiratory motile cilium physiology (HP:0012261)	4.09391465
7	Abnormality of midbrain morphology (HP:0002418)	4.04960808
8	Molar tooth sign on MRI (HP:0002419)	4.04960808
9	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.91443088
10	Nephronophthisis (HP:0000090)	3.79430255
11	Pancreatic cysts (HP:0001737)	3.68961531
12	Chronic hepatic failure (HP:0100626)	3.63611673
13	True hermaphroditism (HP:0010459)	3.61953615
14	Pancreatic fibrosis (HP:0100732)	3.60098516
15	Medial flaring of the eyebrow (HP:0010747)	3.36519360
16	Progressive cerebellar ataxia (HP:0002073)	3.13940694
17	Abnormality of the renal medulla (HP:0100957)	3.12176630
18	Gait imbalance (HP:0002141)	3.05619621
19	Tubulointerstitial nephritis (HP:0001970)	2.88119545
20	Oligodactyly (hands) (HP:0001180)	2.86250845
21	Cystic liver disease (HP:0006706)	2.84400672
22	Congenital primary aphakia (HP:0007707)	2.84324325
23	Rhinitis (HP:0012384)	2.82835474
24	Occipital encephalocele (HP:0002085)	2.74479355
25	Anencephaly (HP:0002323)	2.73242956
26	Nephrogenic diabetes insipidus (HP:0009806)	2.64928065
27	Septo-optic dysplasia (HP:0100842)	2.60527613
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.54174711
29	Sclerocornea (HP:0000647)	2.46830233
30	Acute necrotizing encephalopathy (HP:0006965)	2.43317805
31	Male pseudohermaphroditism (HP:0000037)	2.39664835
32	Severe visual impairment (HP:0001141)	2.39261260
33	Tubular atrophy (HP:0000092)	2.37245012
34	Vaginal atresia (HP:0000148)	2.37120843
35	Hyperglycinemia (HP:0002154)	2.37021389
36	Abnormal drinking behavior (HP:0030082)	2.33379717
37	Polydipsia (HP:0001959)	2.33379717
38	Genital tract atresia (HP:0001827)	2.32692592
39	Anophthalmia (HP:0000528)	2.31255095
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.29042622
41	Poor coordination (HP:0002370)	2.26496233
42	Renal Fanconi syndrome (HP:0001994)	2.24960221
43	Mitochondrial inheritance (HP:0001427)	2.24210478
44	Intestinal atresia (HP:0011100)	2.24099821
45	Pendular nystagmus (HP:0012043)	2.23279633
46	Postaxial foot polydactyly (HP:0001830)	2.21411817
47	Abnormality of the pubic bones (HP:0003172)	2.20996280
48	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.20381952
49	Bony spicule pigmentary retinopathy (HP:0007737)	2.18513341
50	Abnormality of the renal cortex (HP:0011035)	2.16571469
51	Optic nerve hypoplasia (HP:0000609)	2.16504329
52	Oligodactyly (HP:0012165)	2.12718303
53	Acute encephalopathy (HP:0006846)	2.07498720
54	Postaxial hand polydactyly (HP:0001162)	2.03763968
55	Bronchiectasis (HP:0002110)	2.03538749
56	Congenital hepatic fibrosis (HP:0002612)	2.03311230
57	Colon cancer (HP:0003003)	2.03060846
58	Focal motor seizures (HP:0011153)	2.01703782
59	Infertility (HP:0000789)	2.00687052
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.99616686
61	Abnormality of the labia minora (HP:0012880)	1.99259237
62	Lipid accumulation in hepatocytes (HP:0006561)	1.99049604
63	Abnormal mitochondria in muscle tissue (HP:0008316)	1.98781629
64	Retinitis pigmentosa (HP:0000510)	1.97524930
65	Adrenal hypoplasia (HP:0000835)	1.97145857
66	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.95014261
67	Increased hepatocellular lipid droplets (HP:0006565)	1.94543197
68	Hepatocellular necrosis (HP:0001404)	1.91252607
69	Abnormal biliary tract physiology (HP:0012439)	1.91191951
70	Bile duct proliferation (HP:0001408)	1.91191951
71	Type II lissencephaly (HP:0007260)	1.90734290
72	Impulsivity (HP:0100710)	1.90202746
73	Progressive macrocephaly (HP:0004481)	1.89132802
74	Congenital stationary night blindness (HP:0007642)	1.88569267
75	Increased CSF lactate (HP:0002490)	1.87946650
76	Gaze-evoked nystagmus (HP:0000640)	1.87188381
77	Preaxial hand polydactyly (HP:0001177)	1.86426052
78	Myokymia (HP:0002411)	1.85477948
79	Chronic bronchitis (HP:0004469)	1.83287896
80	Abnormality of renal resorption (HP:0011038)	1.81747777
81	Optic disc pallor (HP:0000543)	1.79388800
82	Esophageal atresia (HP:0002032)	1.79239591
83	Tubulointerstitial abnormality (HP:0001969)	1.78771371
84	Gastrointestinal atresia (HP:0002589)	1.78494078
85	Reticulocytopenia (HP:0001896)	1.78261962
86	Maternal diabetes (HP:0009800)	1.78147022
87	Synostosis involving the elbow (HP:0003938)	1.75705342
88	Humeroradial synostosis (HP:0003041)	1.75705342
89	Polyuria (HP:0000103)	1.75253710
90	Oculomotor apraxia (HP:0000657)	1.75227040
91	Attenuation of retinal blood vessels (HP:0007843)	1.75199257
92	Genetic anticipation (HP:0003743)	1.73874720
93	Disproportionate short-trunk short stature (HP:0003521)	1.71034646
94	Glycosuria (HP:0003076)	1.70448297
95	Abnormality of urine glucose concentration (HP:0011016)	1.70448297
96	Abnormality of the aortic arch (HP:0012303)	1.67300823
97	Action tremor (HP:0002345)	1.64111348
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.63786210
99	Aganglionic megacolon (HP:0002251)	1.62732864
100	Focal seizures (HP:0007359)	1.62360506

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	3.81040804
2	BMPR1B	3.09810692
3	FRK	2.97858099
4	PNCK	2.90406851
5	CASK	2.76334199
6	PINK1	2.66322475
7	WNK4	2.64062830
8	MAPK15	2.57548052
9	TNIK	2.39149350
10	PLK4	2.18579754
11	MAP3K4	2.00819748
12	STK16	1.91597380
13	GRK1	1.90150626
14	ADRBK2	1.90049682
15	DYRK2	1.88705151
16	CDK19	1.86206744
17	EPHA4	1.81816734
18	MAP2K7	1.75279675
19	OXSR1	1.75122033
20	MAP4K2	1.74411477
21	NTRK2	1.70231624
22	NME1	1.59942260
23	MAPK13	1.59372831
24	MARK1	1.50641097
25	ACVR1B	1.44951033
26	PAK3	1.37910129
27	ZAK	1.30933027
28	PRKCG	1.16947834
29	TGFBR1	1.15984586
30	INSRR	1.15703339
31	STK39	1.08771574
32	NUAK1	1.07024235
33	MET	1.05370775
34	NTRK3	1.04268211
35	TAF1	1.02120627
36	FGFR2	1.01852520
37	BCKDK	1.01459842
38	BCR	0.98611697
39	TLK1	0.97099246
40	PRKD3	0.94236230
41	TIE1	0.92682835
42	VRK1	0.91805990
43	WEE1	0.89476721
44	MKNK2	0.88892889
45	CSNK1G2	0.87306427
46	PDK2	0.85230105
47	PHKG2	0.84879145
48	PHKG1	0.84879145
49	STK38L	0.84371119
50	PLK2	0.82375062
51	PKN1	0.78109493
52	CSNK1G3	0.76829062
53	MAP3K7	0.76604466
54	MAP2K6	0.74188747
55	CSNK1G1	0.73525938
56	NEK2	0.71220157
57	MKNK1	0.70360246
58	DAPK2	0.70210717
59	CAMK1	0.68675752
60	WNK1	0.68426677
61	CSNK1A1L	0.68057427
62	STK11	0.66284243
63	PRKCE	0.65226524
64	EPHB2	0.64278388
65	MINK1	0.63833623
66	NLK	0.63173261
67	PTK2B	0.63156520
68	SGK223	0.61422985
69	SGK494	0.61422985
70	PRKCZ	0.60139691
71	CDC7	0.58512053
72	CDK3	0.58469955
73	DYRK3	0.58417195
74	CDK8	0.57888870
75	OBSCN	0.57598058
76	CAMK1G	0.56646589
77	CSNK1A1	0.56280961
78	ERBB3	0.55463072
79	SGK1	0.54151931
80	CAMKK2	0.53532118
81	PRKACA	0.52368217
82	TYRO3	0.48240891
83	UHMK1	0.46619314
84	ERBB2	0.44271565
85	MAP2K4	0.43709993
86	BRSK2	0.43549612
87	STK3	0.43145973
88	DYRK1A	0.42561579
89	MUSK	0.42453597
90	TNK2	0.42217879
91	CDK5	0.41685576
92	DDR2	0.41363096
93	PRKCQ	0.41339493
94	PLK1	0.41151173
95	CSNK1E	0.40777028
96	PRKG1	0.40276642
97	CAMK2A	0.40202209
98	ADRBK1	0.39037309
99	DYRK1B	0.38998963
100	PRKACB	0.38666056

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.24594806
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.14249579
3	Parkinsons disease_Homo sapiens_hsa05012	2.78522718
4	Huntingtons disease_Homo sapiens_hsa05016	2.35536392
5	Phototransduction_Homo sapiens_hsa04744	2.24111945
6	Ribosome_Homo sapiens_hsa03010	2.22710155
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.20066150
8	Butanoate metabolism_Homo sapiens_hsa00650	2.17356621
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94352787
10	Nicotine addiction_Homo sapiens_hsa05033	1.94154740
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.84942366
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84006316
13	Olfactory transduction_Homo sapiens_hsa04740	1.83168321
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.79967817
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.77162699
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74980208
17	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.71576807
18	Alzheimers disease_Homo sapiens_hsa05010	1.71274072
19	Basal transcription factors_Homo sapiens_hsa03022	1.69381966
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.65896677
21	Protein export_Homo sapiens_hsa03060	1.58936775
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.58649632
23	Propanoate metabolism_Homo sapiens_hsa00640	1.53024067
24	RNA polymerase_Homo sapiens_hsa03020	1.51293012
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.45747878
26	Homologous recombination_Homo sapiens_hsa03440	1.45679059
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39947281
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39652590
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.39133712
30	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.37233303
31	Retinol metabolism_Homo sapiens_hsa00830	1.32234183
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.26208824
33	Peroxisome_Homo sapiens_hsa04146	1.26005001
34	Taste transduction_Homo sapiens_hsa04742	1.24526149
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.21412245
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.20796914
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.18531489
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.17433132
39	beta-Alanine metabolism_Homo sapiens_hsa00410	1.16529944
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.14525719
41	GABAergic synapse_Homo sapiens_hsa04727	1.14325171
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.13442868
43	Insulin secretion_Homo sapiens_hsa04911	1.03408899
44	Glutamatergic synapse_Homo sapiens_hsa04724	1.01300847
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.01136320
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.00733987
47	RNA degradation_Homo sapiens_hsa03018	0.99048392
48	Fatty acid degradation_Homo sapiens_hsa00071	0.96286935
49	Basal cell carcinoma_Homo sapiens_hsa05217	0.95674422
50	Circadian entrainment_Homo sapiens_hsa04713	0.95445964
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.94658534
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94403397
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92867481
54	Morphine addiction_Homo sapiens_hsa05032	0.92804974
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.90535433
56	Caffeine metabolism_Homo sapiens_hsa00232	0.89443070
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.86187193
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.85208338
59	Histidine metabolism_Homo sapiens_hsa00340	0.83925398
60	Metabolic pathways_Homo sapiens_hsa01100	0.82469137
61	Cocaine addiction_Homo sapiens_hsa05030	0.82134851
62	Purine metabolism_Homo sapiens_hsa00230	0.79922201
63	Salivary secretion_Homo sapiens_hsa04970	0.78192519
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.76804860
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.74832558
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74025220
67	Serotonergic synapse_Homo sapiens_hsa04726	0.72708762
68	Regulation of autophagy_Homo sapiens_hsa04140	0.70357515
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70328169
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69000985
71	Axon guidance_Homo sapiens_hsa04360	0.67548630
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.66703651
73	Pyrimidine metabolism_Homo sapiens_hsa00240	0.62286687
74	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59477868
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58795435
76	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.58728709
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56078617
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55993534
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55990191
80	Oocyte meiosis_Homo sapiens_hsa04114	0.51962913
81	Folate biosynthesis_Homo sapiens_hsa00790	0.51343838
82	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.51239189
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50833601
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.50657779
85	Base excision repair_Homo sapiens_hsa03410	0.50638023
86	Nucleotide excision repair_Homo sapiens_hsa03420	0.49985868
87	ABC transporters_Homo sapiens_hsa02010	0.48814970
88	Amphetamine addiction_Homo sapiens_hsa05031	0.47492892
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47208189
90	Sulfur relay system_Homo sapiens_hsa04122	0.47073127
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.44564000
92	Gastric acid secretion_Homo sapiens_hsa04971	0.44234471
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.40795913
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.40302531
95	RNA transport_Homo sapiens_hsa03013	0.39936640
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39131541
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38673513
98	Fatty acid elongation_Homo sapiens_hsa00062	0.38411796
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38120450
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.37699799

AGAP12P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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