AGAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.46737738
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.06325922
3locomotory exploration behavior (GO:0035641)6.04622522
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.59840073
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30211286
6vocalization behavior (GO:0071625)5.15885625
7layer formation in cerebral cortex (GO:0021819)5.10152639
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.97335004
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.96245869
10glutamate secretion (GO:0014047)4.93223175
11synaptic vesicle exocytosis (GO:0016079)4.84431184
12regulation of synaptic vesicle exocytosis (GO:2000300)4.72805640
13regulation of glutamate receptor signaling pathway (GO:1900449)4.65081954
14regulation of synapse structural plasticity (GO:0051823)4.58770043
15exploration behavior (GO:0035640)4.45902687
16sodium ion export (GO:0071436)4.35501599
17dendritic spine morphogenesis (GO:0060997)4.31962113
18regulation of neuronal synaptic plasticity (GO:0048168)4.31766877
19neurotransmitter secretion (GO:0007269)4.29769297
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.21142827
21regulation of synaptic vesicle transport (GO:1902803)4.20017874
22protein localization to synapse (GO:0035418)4.13925813
23proline transport (GO:0015824)4.03885389
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.95339129
25cellular potassium ion homeostasis (GO:0030007)3.94382231
26activation of protein kinase A activity (GO:0034199)3.92562024
27cerebellar granule cell differentiation (GO:0021707)3.90769414
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.85143272
29L-amino acid import (GO:0043092)3.81343299
30positive regulation of synapse maturation (GO:0090129)3.79687989
31cell communication by electrical coupling (GO:0010644)3.78211980
32neuromuscular process controlling balance (GO:0050885)3.76619079
33amino acid import (GO:0043090)3.71313286
34gamma-aminobutyric acid transport (GO:0015812)3.69890338
35neurotransmitter-gated ion channel clustering (GO:0072578)3.63816188
36neuronal action potential propagation (GO:0019227)3.61886583
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.55344592
38long-term memory (GO:0007616)3.53350921
39regulation of ARF protein signal transduction (GO:0032012)3.52666093
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.51596108
41synaptic transmission, glutamatergic (GO:0035249)3.48533081
42regulation of dendritic spine morphogenesis (GO:0061001)3.44133973
43cell migration in hindbrain (GO:0021535)3.43152269
44dendrite morphogenesis (GO:0048813)3.41906488
45neuron cell-cell adhesion (GO:0007158)3.40029819
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37746854
47glycine transport (GO:0015816)3.37603647
48regulation of early endosome to late endosome transport (GO:2000641)3.36044516
49cerebellar Purkinje cell layer development (GO:0021680)3.34152746
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.33212915
51positive regulation of membrane potential (GO:0045838)3.33186887
52glutamate receptor signaling pathway (GO:0007215)3.31696573
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.30052597
54potassium ion homeostasis (GO:0055075)3.28040443
55cytoskeletal anchoring at plasma membrane (GO:0007016)3.27542301
56regulation of synaptic plasticity (GO:0048167)3.25691662
57neurotransmitter transport (GO:0006836)3.25245819
58synaptic vesicle endocytosis (GO:0048488)3.25172194
59cell-cell junction maintenance (GO:0045217)3.24147653
60regulation of synapse maturation (GO:0090128)3.23688981
61protein localization to endosome (GO:0036010)3.21361161
62axon ensheathment in central nervous system (GO:0032291)3.20669971
63central nervous system myelination (GO:0022010)3.20669971
64regulation of postsynaptic membrane potential (GO:0060078)3.18433994
65auditory behavior (GO:0031223)3.18166287
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16967789
67semaphorin-plexin signaling pathway (GO:0071526)3.15833659
68prepulse inhibition (GO:0060134)3.15061036
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13809528
70neuron-neuron synaptic transmission (GO:0007270)3.12432733
71cerebellar Purkinje cell differentiation (GO:0021702)3.08445121
72establishment of nucleus localization (GO:0040023)3.08323730
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.08282026
74dendritic spine organization (GO:0097061)3.07544211
75regulation of neurotransmitter secretion (GO:0046928)3.06958841
76neuron recognition (GO:0008038)3.06865634
77neuromuscular process controlling posture (GO:0050884)3.05306170
78regulation of neurotransmitter levels (GO:0001505)3.05057072
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.04723535
80axonal fasciculation (GO:0007413)3.00281221
81vesicle transport along microtubule (GO:0047496)2.99702636
82positive regulation of dendritic spine development (GO:0060999)2.99000518
83cell communication involved in cardiac conduction (GO:0086065)2.95760242
84cellular sodium ion homeostasis (GO:0006883)2.95306954
85response to auditory stimulus (GO:0010996)2.94791205
86membrane depolarization during action potential (GO:0086010)2.93492722
87establishment of mitochondrion localization (GO:0051654)2.93101735
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92800958
89positive regulation of fibroblast migration (GO:0010763)2.92517724
90regulation of clathrin-mediated endocytosis (GO:2000369)2.90026751
91establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.89829932
92mitochondrion transport along microtubule (GO:0047497)2.89829932
93neuronal ion channel clustering (GO:0045161)2.89235714
94positive regulation of neurotransmitter secretion (GO:0001956)2.88949820
95innervation (GO:0060384)2.88053827
96social behavior (GO:0035176)2.87820502
97intraspecies interaction between organisms (GO:0051703)2.87820502
98regulation of dendritic spine development (GO:0060998)2.87681590
99negative regulation of microtubule polymerization (GO:0031115)2.87665434
100potassium ion import (GO:0010107)2.87083143
101neuromuscular process (GO:0050905)2.86353818
102regulation of vesicle fusion (GO:0031338)2.84951943
103positive regulation of neurotransmitter transport (GO:0051590)2.84807596
104regulation of neurotransmitter transport (GO:0051588)2.82170075
105positive regulation of dendritic spine morphogenesis (GO:0061003)2.80380365
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79235978
107membrane depolarization (GO:0051899)2.78671590
108mating behavior (GO:0007617)2.77340740
109clathrin coat assembly (GO:0048268)2.76464676
110dopamine receptor signaling pathway (GO:0007212)2.76179365
111alanine transport (GO:0032328)2.76170672
112transmission of nerve impulse (GO:0019226)2.75297037
113chemosensory behavior (GO:0007635)2.75201508
114activation of MAPKKK activity (GO:0000185)2.75167139
115organelle transport along microtubule (GO:0072384)2.74050232
116postsynaptic membrane organization (GO:0001941)2.69865279
117peptidyl-tyrosine autophosphorylation (GO:0038083)2.64126047
118response to acidic pH (GO:0010447)2.63198223
119negative regulation of erythrocyte differentiation (GO:0045647)2.62555398
120positive regulation of protein dephosphorylation (GO:0035307)2.62300744
121protein retention in ER lumen (GO:0006621)2.62168291
122negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.62074395
123negative regulation of dendrite morphogenesis (GO:0050774)2.58342744
124positive regulation of dendrite development (GO:1900006)2.56779314
125regulation of voltage-gated calcium channel activity (GO:1901385)2.50268507
126regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.47579859
127barbed-end actin filament capping (GO:0051016)2.44681922
128adenosine receptor signaling pathway (GO:0001973)2.44010143
129dicarboxylic acid transport (GO:0006835)2.43530643
130mannose metabolic process (GO:0006013)2.41893964
131regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.41745419
132signal complex assembly (GO:0007172)2.38845003
133regulation of synaptic transmission (GO:0050804)2.37263294
134cell differentiation in hindbrain (GO:0021533)2.35545140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.88368452
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.24332521
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.04506107
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.95718821
5DROSHA_22980978_ChIP-Seq_HELA_Human2.73783716
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73166348
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71871616
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70957132
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65515725
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65515725
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.65447330
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54232148
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.48168617
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45636820
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43900245
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.40063702
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25950034
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.25323810
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.23855305
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23691710
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22566798
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.20250395
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.19640905
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18837586
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.18108804
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.16566771
27ZFP281_18757296_ChIP-ChIP_E14_Mouse2.15163223
28RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15138002
29KDM2B_26808549_Chip-Seq_K562_Human2.09919169
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98013156
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93632121
32* ELK3_25401928_ChIP-Seq_HUVEC_Human1.88921089
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.87112961
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.85217314
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83167364
36* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80447738
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.79665786
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74388185
39* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71722786
40VDR_21846776_ChIP-Seq_THP-1_Human1.70839180
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69313080
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68483695
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64965272
44* LXR_22292898_ChIP-Seq_THP-1_Human1.55863830
45GBX2_23144817_ChIP-Seq_PC3_Human1.55132142
46KDM2B_26808549_Chip-Seq_DND41_Human1.50970950
47* TET1_21451524_ChIP-Seq_MESCs_Mouse1.50179006
48* RING1B_27294783_Chip-Seq_ESCs_Mouse1.48315101
49RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46557869
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46035460
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45685897
52ZNF263_19887448_ChIP-Seq_K562_Human1.43288605
53* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42519142
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42367987
55* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42014068
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.39754467
57AR_21572438_ChIP-Seq_LNCaP_Human1.39637679
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39527720
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37961527
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35467728
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35273253
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.34281519
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33839951
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33729114
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.31963809
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30836003
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30320872
68CTCF_27219007_Chip-Seq_Bcells_Human1.24670099
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22653865
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.18032120
71AR_19668381_ChIP-Seq_PC3_Human1.17161303
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.16385421
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16133978
74* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14712932
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13602722
76ZNF274_21170338_ChIP-Seq_K562_Hela1.12990689
77CREB1_26743006_Chip-Seq_LNCaP_Human1.12356477
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11033903
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.10542813
80SMC4_20622854_ChIP-Seq_HELA_Human1.10077293
81MYC_22102868_ChIP-Seq_BL_Human1.07587508
82TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.07258642
83SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07174105
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06223133
85* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06116412
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05123058
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04885603
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03925264
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.03551411
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03218383
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.03139703
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02140686
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01777609
94TP53_20018659_ChIP-ChIP_R1E_Mouse1.00906628
95CLOCK_20551151_ChIP-Seq_293T_Human0.99689178
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98877596
97SA1_27219007_Chip-Seq_Bcells_Human0.98749819
98KLF4_19829295_ChIP-Seq_ESCs_Human0.98304192
99TP53_22127205_ChIP-Seq_IMR90_Human0.97738213
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95626318
101* TP63_22573176_ChIP-Seq_HFKS_Human0.95271723
102TP53_23651856_ChIP-Seq_MEFs_Mouse0.94839792
103OCT4_19829295_ChIP-Seq_ESCs_Human0.93690722
104* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93685895
105* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90593200
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.90139443
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89594863
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89061792
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89020411
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88972774
111AHR_22903824_ChIP-Seq_MCF-7_Human0.87454729
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86914265
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86884850
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.86235972
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86166118
116TCF7_22412390_ChIP-Seq_EML_Mouse0.85225881
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.84389093
118RACK7_27058665_Chip-Seq_MCF-7_Human0.83391118
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83370703
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83190883
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82976994
122SMAD4_21799915_ChIP-Seq_A2780_Human0.82874503
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82775624
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81007911
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80212766
126P68_20966046_ChIP-Seq_HELA_Human0.78601894
127CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78443568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.13445435
2MP0003635_abnormal_synaptic_transmissio4.11449658
3MP0004270_analgesia3.64308462
4MP0003880_abnormal_central_pattern3.53565576
5MP0002063_abnormal_learning/memory/cond3.23035343
6MP0009745_abnormal_behavioral_response3.04499037
7MP0005058_abnormal_lysosome_morphology3.02889950
8MP0002064_seizures2.84955269
9MP0005423_abnormal_somatic_nervous2.67310007
10MP0002822_catalepsy2.67051538
11MP0009046_muscle_twitch2.67034597
12MP0004858_abnormal_nervous_system2.66511019
13MP0001968_abnormal_touch/_nociception2.56773064
14MP0002572_abnormal_emotion/affect_behav2.41894736
15MP0009780_abnormal_chondrocyte_physiolo2.39694054
16MP0002734_abnormal_mechanical_nocicepti2.39008258
17MP0002909_abnormal_adrenal_gland2.30345432
18MP0003329_amyloid_beta_deposits2.11426596
19MP0002272_abnormal_nervous_system2.10646470
20MP0001486_abnormal_startle_reflex2.04145302
21MP0000920_abnormal_myelination2.00731264
22MP0002733_abnormal_thermal_nociception1.97677113
23MP0004811_abnormal_neuron_physiology1.97201798
24MP0008569_lethality_at_weaning1.96671604
25MP0009840_abnormal_foam_cell1.94732192
26MP0001440_abnormal_grooming_behavior1.93236512
27MP0001501_abnormal_sleep_pattern1.90853093
28MP0002735_abnormal_chemical_nociception1.83378134
29MP0002736_abnormal_nociception_after1.83198023
30MP0008961_abnormal_basal_metabolism1.80374773
31MP0005409_darkened_coat_color1.79883513
32MP0001970_abnormal_pain_threshold1.78119741
33MP0002184_abnormal_innervation1.77047255
34MP0000778_abnormal_nervous_system1.70308677
35MP0000751_myopathy1.70186363
36MP0000955_abnormal_spinal_cord1.68823373
37MP0003283_abnormal_digestive_organ1.68178454
38MP0004885_abnormal_endolymph1.60047705
39MP0002557_abnormal_social/conspecific_i1.59152020
40MP0002067_abnormal_sensory_capabilities1.57638862
41MP0004924_abnormal_behavior1.46893101
42MP0005386_behavior/neurological_phenoty1.46893101
43MP0001849_ear_inflammation1.45419453
44MP0010234_abnormal_vibrissa_follicle1.44634275
45MP0005257_abnormal_intraocular_pressure1.42542446
46MP0003879_abnormal_hair_cell1.39562396
47MP0002882_abnormal_neuron_morphology1.34885823
48MP0003633_abnormal_nervous_system1.34672274
49MP0002066_abnormal_motor_capabilities/c1.34614155
50MP0002249_abnormal_larynx_morphology1.29301560
51MP0003122_maternal_imprinting1.26534215
52MP0003787_abnormal_imprinting1.24141582
53MP0003075_altered_response_to1.22595719
54MP0008260_abnormal_autophagy1.21394348
55MP0002877_abnormal_melanocyte_morpholog1.21066603
56MP0005167_abnormal_blood-brain_barrier1.18811003
57MP0003453_abnormal_keratinocyte_physiol1.17616143
58MP0005623_abnormal_meninges_morphology1.16581153
59MP0002152_abnormal_brain_morphology1.14925647
60MP0004145_abnormal_muscle_electrophysio1.14603620
61MP0003705_abnormal_hypodermis_morpholog1.14399600
62MP0000678_abnormal_parathyroid_gland1.12624492
63MP0004233_abnormal_muscle_weight1.11768611
64MP0004510_myositis1.11689005
65MP0003631_nervous_system_phenotype1.09531246
66MP0005645_abnormal_hypothalamus_physiol1.08726008
67MP0009278_abnormal_bone_marrow1.06882458
68MP0005646_abnormal_pituitary_gland1.06603474
69MP0002234_abnormal_pharynx_morphology1.06529055
70MP0000569_abnormal_digit_pigmentation1.03846719
71MP0004130_abnormal_muscle_cell1.03640187
72MP0000013_abnormal_adipose_tissue1.03197208
73MP0001502_abnormal_circadian_rhythm1.02696829
74MP0000604_amyloidosis1.01684983
75MP0000579_abnormal_nail_morphology1.00565430
76MP0004085_abnormal_heartbeat0.94875969
77MP0001348_abnormal_lacrimal_gland0.94227439
78MP0002069_abnormal_eating/drinking_beha0.93591128
79MP0008874_decreased_physiological_sensi0.93015241
80MP0006276_abnormal_autonomic_nervous0.90768765
81MP0001984_abnormal_olfaction0.90592807
82MP0003137_abnormal_impulse_conducting0.88394837
83MP0003634_abnormal_glial_cell0.87879689
84MP0003279_aneurysm0.86966844
85MP0008872_abnormal_physiological_respon0.86904456
86MP0005499_abnormal_olfactory_system0.85459842
87MP0005394_taste/olfaction_phenotype0.85459842
88MP0000681_abnormal_thyroid_gland0.84725230
89MP0001177_atelectasis0.84553219
90MP0002837_dystrophic_cardiac_calcinosis0.83722313
91MP0005187_abnormal_penis_morphology0.83250462
92MP0003690_abnormal_glial_cell0.83184429
93MP0005451_abnormal_body_composition0.81191356
94MP0003632_abnormal_nervous_system0.79942351
95MP0000747_muscle_weakness0.79295715
96MP0005166_decreased_susceptibility_to0.76449115
97MP0004215_abnormal_myocardial_fiber0.76303956
98MP0001299_abnormal_eye_distance/0.75927754
99MP0004742_abnormal_vestibular_system0.75320304
100MP0002090_abnormal_vision0.75124505
101MP0000537_abnormal_urethra_morphology0.74619264
102MP0003191_abnormal_cellular_cholesterol0.74571370
103MP0000343_altered_response_to0.74463599
104MP0002653_abnormal_ependyma_morphology0.74062840
105MP0003123_paternal_imprinting0.73829557
106MP0001346_abnormal_lacrimal_gland0.73656861
107MP0003172_abnormal_lysosome_physiology0.72330702
108MP0002229_neurodegeneration0.70607267
109MP0002089_abnormal_postnatal_growth/wei0.70549319
110MP0001963_abnormal_hearing_physiology0.69607218
111MP0003861_abnormal_nervous_system0.69022063
112MP0004142_abnormal_muscle_tone0.67964506
113MP0005535_abnormal_body_temperature0.67038848
114MP0002998_abnormal_bone_remodeling0.65583099
115MP0002896_abnormal_bone_mineralization0.65484117
116MP0005375_adipose_tissue_phenotype0.64857585
117MP0004484_altered_response_of0.64770590
118MP0003303_peritoneal_inflammation0.64656442
119MP0003091_abnormal_cell_migration0.64625613
120MP0000733_abnormal_muscle_development0.64458520
121MP0004087_abnormal_muscle_fiber0.63367808
122MP0008438_abnormal_cutaneous_collagen0.63047122
123MP0000003_abnormal_adipose_tissue0.62599948
124MP0000566_synostosis0.62393674
125MP0000534_abnormal_ureter_morphology0.58919207
126MP0001943_abnormal_respiration0.58854357
127MP0005595_abnormal_vascular_smooth0.58833547
128MP0010769_abnormal_survival0.57754976
129MP0005666_abnormal_adipose_tissue0.57250372
130MP0001958_emphysema0.55935308
131MP0000631_abnormal_neuroendocrine_gland0.55700481
132MP0005076_abnormal_cell_differentiation0.55404566

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.20688854
2Focal motor seizures (HP:0011153)5.04091919
3Visual hallucinations (HP:0002367)4.81894422
4Focal seizures (HP:0007359)4.50680115
5Supranuclear gaze palsy (HP:0000605)3.92097976
6Abnormality of the lower motor neuron (HP:0002366)3.81390267
7Action tremor (HP:0002345)3.74632154
8Ankle clonus (HP:0011448)3.43742969
9Depression (HP:0000716)3.32310315
10Epileptic encephalopathy (HP:0200134)3.23382697
11Progressive cerebellar ataxia (HP:0002073)3.22840227
12Insomnia (HP:0100785)3.15745206
13Abnormality of liposaccharide metabolism (HP:0010968)3.12667633
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.12667633
15Abnormality of glycolipid metabolism (HP:0010969)3.12667633
16Poor eye contact (HP:0000817)3.08189104
17Ventricular fibrillation (HP:0001663)3.06974986
18Impaired vibration sensation in the lower limbs (HP:0002166)2.97378633
19Nuclear cataract (HP:0100018)2.95723571
20Absence seizures (HP:0002121)2.94558450
21Impaired social interactions (HP:0000735)2.93249327
22Abnormal social behavior (HP:0012433)2.93249327
23Cerebral aneurysm (HP:0004944)2.92815144
24Generalized tonic-clonic seizures (HP:0002069)2.92741731
25Papilledema (HP:0001085)2.89588031
26Mutism (HP:0002300)2.88070863
27Atonic seizures (HP:0010819)2.87600616
28Postural instability (HP:0002172)2.85112663
29Annular pancreas (HP:0001734)2.85088324
30Axonal loss (HP:0003447)2.84349891
31Urinary bladder sphincter dysfunction (HP:0002839)2.75596205
32Increased cerebral lipofuscin (HP:0011813)2.75580476
33Cerebral inclusion bodies (HP:0100314)2.73502821
34Pointed chin (HP:0000307)2.71665341
35Urinary urgency (HP:0000012)2.70098634
36Torticollis (HP:0000473)2.69766495
37Febrile seizures (HP:0002373)2.69666731
38Megalencephaly (HP:0001355)2.67656547
39Hyperacusis (HP:0010780)2.65837782
40Genetic anticipation (HP:0003743)2.65735285
41Hemiplegia (HP:0002301)2.64014914
42Anxiety (HP:0000739)2.60425846
43Dysdiadochokinesis (HP:0002075)2.60261595
44Dialeptic seizures (HP:0011146)2.58741287
45Dysmetric saccades (HP:0000641)2.58324764
46Obstructive sleep apnea (HP:0002870)2.56897244
47Amblyopia (HP:0000646)2.55257301
48Peripheral hypomyelination (HP:0007182)2.54169687
49Bundle branch block (HP:0011710)2.54067294
50Dysostosis multiplex (HP:0000943)2.53118349
51Neurofibrillary tangles (HP:0002185)2.44631697
52Broad-based gait (HP:0002136)2.44618961
53Impaired smooth pursuit (HP:0007772)2.43936119
54Abnormal eating behavior (HP:0100738)2.42522411
55Dysmetria (HP:0001310)2.42269980
56Focal dystonia (HP:0004373)2.41427342
57Truncal ataxia (HP:0002078)2.36814688
58Ankyloglossia (HP:0010296)2.34884337
59Insidious onset (HP:0003587)2.33554076
60Termporal pattern (HP:0011008)2.33554076
61Hemiparesis (HP:0001269)2.32524054
62Achilles tendon contracture (HP:0001771)2.31355887
63Distal upper limb amyotrophy (HP:0007149)2.27634760
64Upper limb amyotrophy (HP:0009129)2.27634760
65Lower limb amyotrophy (HP:0007210)2.26548916
66Stereotypic behavior (HP:0000733)2.25759478
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.25474409
68Rapidly progressive (HP:0003678)2.25031827
69Intention tremor (HP:0002080)2.24211980
70Abnormality of binocular vision (HP:0011514)2.23784727
71Diplopia (HP:0000651)2.23784727
72Hypercortisolism (HP:0001578)2.23267001
73Apathy (HP:0000741)2.23254273
74Gaze-evoked nystagmus (HP:0000640)2.22995452
75Dementia (HP:0000726)2.21987838
76Spastic gait (HP:0002064)2.20184136
77Bradykinesia (HP:0002067)2.19952613
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18147135
79Craniofacial dystonia (HP:0012179)2.17858883
80Amyotrophic lateral sclerosis (HP:0007354)2.17040976
81Elfin facies (HP:0004428)2.16709129
82Hyperparathyroidism (HP:0000843)2.13943544
83Akinesia (HP:0002304)2.12858415
84Abnormality of ocular smooth pursuit (HP:0000617)2.10503338
85Abnormality of the Achilles tendon (HP:0005109)2.07468908
86J-shaped sella turcica (HP:0002680)2.05650285
87Neuronal loss in central nervous system (HP:0002529)2.05087645
88Hyperthyroidism (HP:0000836)2.04999563
89Loss of speech (HP:0002371)2.04452181
90Agitation (HP:0000713)2.03663146
91Tetraplegia (HP:0002445)2.03247177
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02661084
93Resting tremor (HP:0002322)2.01585705
94Lower limb muscle weakness (HP:0007340)2.01540892
95Neoplasm of the heart (HP:0100544)2.01498514
96Distal lower limb amyotrophy (HP:0008944)2.00085278
97Diminished motivation (HP:0000745)1.99761048
98Hypoventilation (HP:0002791)1.98699618
99Macroorchidism (HP:0000053)1.97068619
100Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96229627
101Abnormality of polysaccharide metabolism (HP:0011012)1.96229627
102Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96229627
103Overriding aorta (HP:0002623)1.96184368
104Drooling (HP:0002307)1.96065156
105Excessive salivation (HP:0003781)1.96065156
106Hand muscle atrophy (HP:0009130)1.96004969
107Lower limb asymmetry (HP:0100559)1.95708435
108Status epilepticus (HP:0002133)1.95452116
109Mucopolysacchariduria (HP:0008155)1.93184024
110Urinary glycosaminoglycan excretion (HP:0003541)1.93184024
111Sudden death (HP:0001699)1.92258156
112Stridor (HP:0010307)1.92113216
113Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89079067
114Rigidity (HP:0002063)1.89020770
115Aplasia involving bones of the upper limbs (HP:0009823)1.88787708
116Aplasia of the phalanges of the hand (HP:0009802)1.88787708
117Aplasia involving bones of the extremities (HP:0009825)1.88787708
118Distal sensory impairment (HP:0002936)1.87103870
119Truncus arteriosus (HP:0001660)1.86444469
120Disinhibition (HP:0000734)1.86421237
121Turricephaly (HP:0000262)1.86274735
122Abnormality of the corticospinal tract (HP:0002492)1.85601433
123Intellectual disability, profound (HP:0002187)1.84474703
124Impaired vibratory sensation (HP:0002495)1.84470219
125Failure to thrive in infancy (HP:0001531)1.83726805
126Bowel incontinence (HP:0002607)1.83362408
127Thin bony cortex (HP:0002753)1.82989114
128Renovascular hypertension (HP:0100817)1.82309978
129Renal duplication (HP:0000075)1.82159672
130Sleep apnea (HP:0010535)1.82119151
131Clonus (HP:0002169)1.81173337
132Delusions (HP:0000746)1.80841575
133Hammertoe (HP:0001765)1.80288191
134Bronchomalacia (HP:0002780)1.79466673
135Abnormal EKG (HP:0003115)1.79303933
136Ulnar bowing (HP:0003031)1.78818719
137Abnormal large intestine physiology (HP:0012700)1.78423930
138Systemic lupus erythematosus (HP:0002725)1.78355002
139Shallow orbits (HP:0000586)1.78076356
140Difficulty running (HP:0009046)1.75505123
141Long palpebral fissure (HP:0000637)1.74584828
142Progressive inability to walk (HP:0002505)1.74444869
143Urinary incontinence (HP:0000020)1.72524276
144Spastic tetraparesis (HP:0001285)1.70819052
145Upper motor neuron abnormality (HP:0002127)1.70116995
146Spinal canal stenosis (HP:0003416)1.70110005
147Foot dorsiflexor weakness (HP:0009027)1.69931264
148Abnormality of the periventricular white matter (HP:0002518)1.69348032
149Vertebral compression fractures (HP:0002953)1.69118741
150Mitral regurgitation (HP:0001653)1.66531511
151Broad face (HP:0000283)1.66496817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.01415294
2NTRK33.58886426
3MARK13.29611153
4EPHA43.28324647
5PRKD32.76868248
6DAPK22.76839492
7KSR22.57087329
8PAK62.56418568
9MINK12.53034142
10IRAK32.44968583
11MAP3K42.40569222
12TRIB32.30184652
13CAMKK12.24865996
14SIK12.12826815
15NTRK22.00549111
16NTRK11.89708307
17RIPK11.82378746
18SIK21.73425381
19TYRO31.72324327
20MAP3K111.70147738
21MAP2K41.67550263
22KSR11.55898177
23TAOK11.55645571
24LATS21.54868757
25NME21.54688832
26STK381.52579011
27MAP3K21.50829154
28CDK51.46861828
29PKN21.44699000
30PHKG11.44684741
31PHKG21.44684741
32SMG11.42797121
33CAMK1D1.34397284
34DAPK11.31516391
35MAP2K71.29319416
36LMTK21.26537194
37ALK1.26524134
38RET1.24137061
39TAOK21.19740807
40UHMK11.19708109
41TESK11.08449756
42GRK51.08045037
43RIPK41.07809135
44SCYL21.06789623
45PRKCH1.05289511
46BRAF1.01602447
47STK110.98995241
48PDGFRA0.95435246
49NEK10.94694678
50PRKCG0.94106519
51ERN10.92535779
52CDK150.92189486
53ICK0.92075936
54CDK180.88907412
55FES0.87593385
56MARK20.86921023
57CAMK10.85614990
58CAMKK20.85170324
59CDK140.84928194
60IRAK20.83185800
61PIM20.81725008
62ARAF0.81452594
63PAK30.80935460
64EEF2K0.80527950
65CDK11A0.80128155
66CAMK1G0.79938190
67MAP3K10.77595479
68SGK30.76851126
69CAMK2B0.76051990
70CDK120.76042187
71DMPK0.75351756
72PLK20.75133837
73MOS0.73566663
74LIMK10.71633484
75MAP3K130.71324367
76BMX0.71222699
77CAMK2G0.70981433
78MAP3K70.70939010
79PRKD20.69594114
80RAF10.68573215
81PDPK10.68145347
82SGK4940.68027514
83SGK2230.68027514
84MAPK130.66966134
85PDK10.66592663
86CDC42BPA0.66159916
87MTOR0.66019304
88PTK2B0.65475746
89PRPF4B0.65271957
90RPS6KA20.63048346
91PINK10.62986956
92ABL20.61919563
93CAMK40.61244376
94CDK190.60843767
95TTN0.60567975
96DAPK30.59228980
97DDR20.58369200
98PNCK0.57958337
99NEK60.56687223
100CAMK2A0.56382939
101MAP3K120.56137953
102SGK10.55403158
103FER0.55210216
104PRKG20.54423593
105PRKCZ0.53381103
106PTK60.52363133
107EPHA20.51956148
108MAP2K30.49931913
109DYRK1B0.49315811
110RPS6KA30.49204769
111MAP2K60.48946130
112CSNK1G20.48283563
113MAP2K10.47876530
114SGK20.47232046
115DYRK1A0.45487082
116TNK20.44683795
117BRSK10.43798740
118MAPK100.43134661
119FYN0.43010973
120PTK20.42639323
121PKN10.41911053
122MAPK120.41325213
123RPS6KC10.41305325
124RPS6KL10.41305325
125FGFR40.40736156
126MAP3K30.40610392
127EPHB20.39677113
128FGFR20.38740312
129MAP3K60.34814010
130MAPK80.34774151
131PRKD10.34542574
132WNK10.34039817

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.89010007
2Nicotine addiction_Homo sapiens_hsa050332.53481173
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.48661385
4Olfactory transduction_Homo sapiens_hsa047402.42827311
5Long-term potentiation_Homo sapiens_hsa047202.36613373
6Circadian entrainment_Homo sapiens_hsa047132.33390925
7GABAergic synapse_Homo sapiens_hsa047272.18864235
8Glutamatergic synapse_Homo sapiens_hsa047242.15733799
9Amphetamine addiction_Homo sapiens_hsa050312.03681085
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01157491
11Morphine addiction_Homo sapiens_hsa050321.96637702
12Salivary secretion_Homo sapiens_hsa049701.90805723
13Dopaminergic synapse_Homo sapiens_hsa047281.90138987
14Gastric acid secretion_Homo sapiens_hsa049711.85584007
15Other glycan degradation_Homo sapiens_hsa005111.85089942
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84468990
17Insulin secretion_Homo sapiens_hsa049111.83321012
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80475256
19Cholinergic synapse_Homo sapiens_hsa047251.79100434
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65137741
21Nitrogen metabolism_Homo sapiens_hsa009101.60566094
22Oxytocin signaling pathway_Homo sapiens_hsa049211.60404447
23Vitamin B6 metabolism_Homo sapiens_hsa007501.55045950
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54820031
25GnRH signaling pathway_Homo sapiens_hsa049121.53139976
26Renin secretion_Homo sapiens_hsa049241.48815702
27Cocaine addiction_Homo sapiens_hsa050301.47247239
28Glioma_Homo sapiens_hsa052141.44921470
29Type II diabetes mellitus_Homo sapiens_hsa049301.43856683
30Lysosome_Homo sapiens_hsa041421.43317815
31Gap junction_Homo sapiens_hsa045401.43011375
32Long-term depression_Homo sapiens_hsa047301.42290646
33Estrogen signaling pathway_Homo sapiens_hsa049151.35680279
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.34188808
35Calcium signaling pathway_Homo sapiens_hsa040201.28215642
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28206485
37Notch signaling pathway_Homo sapiens_hsa043301.27082735
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25737428
39Taste transduction_Homo sapiens_hsa047421.24488530
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24307122
41cAMP signaling pathway_Homo sapiens_hsa040241.17314576
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14541338
43Melanogenesis_Homo sapiens_hsa049161.14349035
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13372109
45Axon guidance_Homo sapiens_hsa043601.11397108
46ErbB signaling pathway_Homo sapiens_hsa040121.09066866
47Serotonergic synapse_Homo sapiens_hsa047261.08802770
48Dorso-ventral axis formation_Homo sapiens_hsa043201.08235033
49VEGF signaling pathway_Homo sapiens_hsa043701.04270618
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02672201
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.99836989
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99473688
53Dilated cardiomyopathy_Homo sapiens_hsa054140.99448941
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.99173722
55mTOR signaling pathway_Homo sapiens_hsa041500.99059815
56Bladder cancer_Homo sapiens_hsa052190.92956200
57Salmonella infection_Homo sapiens_hsa051320.92171812
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90750926
59Endometrial cancer_Homo sapiens_hsa052130.90570939
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89782693
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88474365
62Oocyte meiosis_Homo sapiens_hsa041140.83537870
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.82902911
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82890342
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82811243
66Non-small cell lung cancer_Homo sapiens_hsa052230.82376491
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79991971
68Choline metabolism in cancer_Homo sapiens_hsa052310.78602820
69Pancreatic secretion_Homo sapiens_hsa049720.77840766
70Cardiac muscle contraction_Homo sapiens_hsa042600.77333526
71MAPK signaling pathway_Homo sapiens_hsa040100.76903199
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75116833
73Thyroid hormone synthesis_Homo sapiens_hsa049180.75021728
74Insulin signaling pathway_Homo sapiens_hsa049100.74874711
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73708141
76Bile secretion_Homo sapiens_hsa049760.73441666
77Amoebiasis_Homo sapiens_hsa051460.72556879
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71300992
79Glucagon signaling pathway_Homo sapiens_hsa049220.71099517
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70596270
81Renal cell carcinoma_Homo sapiens_hsa052110.70455423
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69388359
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69306950
84Rap1 signaling pathway_Homo sapiens_hsa040150.69131583
85* Endocytosis_Homo sapiens_hsa041440.67511701
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.66042402
87Osteoclast differentiation_Homo sapiens_hsa043800.65248659
88Collecting duct acid secretion_Homo sapiens_hsa049660.63238337
89Acute myeloid leukemia_Homo sapiens_hsa052210.61277264
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59850206
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.59260095
92Prion diseases_Homo sapiens_hsa050200.58626405
93Colorectal cancer_Homo sapiens_hsa052100.56541501
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55825364
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54713113
96Ras signaling pathway_Homo sapiens_hsa040140.54620728
97HIF-1 signaling pathway_Homo sapiens_hsa040660.54417221
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54308478
99Tuberculosis_Homo sapiens_hsa051520.52157554
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51845285
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51388068
102Prolactin signaling pathway_Homo sapiens_hsa049170.50864128
103Pertussis_Homo sapiens_hsa051330.49246791
104Chronic myeloid leukemia_Homo sapiens_hsa052200.48969716
105Inositol phosphate metabolism_Homo sapiens_hsa005620.48211489
106Focal adhesion_Homo sapiens_hsa045100.48035060
107Wnt signaling pathway_Homo sapiens_hsa043100.47934424
108Fructose and mannose metabolism_Homo sapiens_hsa000510.46965069
109Vibrio cholerae infection_Homo sapiens_hsa051100.46909945
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46737121
111Proteoglycans in cancer_Homo sapiens_hsa052050.45609847
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44311219
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44024276
114Alcoholism_Homo sapiens_hsa050340.43152966
115Insulin resistance_Homo sapiens_hsa049310.41209068
116Hippo signaling pathway_Homo sapiens_hsa043900.40913753
117Tight junction_Homo sapiens_hsa045300.40621636
118AMPK signaling pathway_Homo sapiens_hsa041520.39493534
119Hedgehog signaling pathway_Homo sapiens_hsa043400.39486658
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.38835863

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