AGAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)7.42897679
2acrosome reaction (GO:0007340)7.34850277
3establishment of protein localization to Golgi (GO:0072600)6.74660348
4protein targeting to Golgi (GO:0000042)6.70426560
5response to pheromone (GO:0019236)6.62813865
6retrograde transport, vesicle recycling within Golgi (GO:0000301)6.33679942
7fusion of sperm to egg plasma membrane (GO:0007342)5.57346890
8single strand break repair (GO:0000012)5.52242812
9rRNA methylation (GO:0031167)5.37211703
10spermatid development (GO:0007286)5.31499132
11protein polyglutamylation (GO:0018095)5.19436599
12centriole replication (GO:0007099)5.17497557
13protein localization to Golgi apparatus (GO:0034067)5.11785353
14phosphatidylethanolamine biosynthetic process (GO:0006646)5.05790695
15cilium or flagellum-dependent cell motility (GO:0001539)4.96880178
16multicellular organism reproduction (GO:0032504)4.92409132
17phosphatidylethanolamine metabolic process (GO:0046337)4.81097780
18regulation of cilium movement (GO:0003352)4.67608918
19plasma membrane fusion (GO:0045026)4.66135501
20epithelial cilium movement (GO:0003351)4.63104801
21sperm capacitation (GO:0048240)4.61627189
22sperm-egg recognition (GO:0035036)4.58988130
23rRNA modification (GO:0000154)4.47961520
24centriole assembly (GO:0098534)4.33150262
25axoneme assembly (GO:0035082)4.30211432
26microtubule polymerization or depolymerization (GO:0031109)4.24865569
27microtubule depolymerization (GO:0007019)4.21462972
28* regulation of ARF GTPase activity (GO:0032312)4.20763149
29regulation of Rab GTPase activity (GO:0032313)4.14724913
30positive regulation of Rab GTPase activity (GO:0032851)4.14724913
31axonemal dynein complex assembly (GO:0070286)4.11271764
32reproduction (GO:0000003)4.09212696
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.07194313
34cell-cell recognition (GO:0009988)4.04677591
35cilium movement (GO:0003341)4.03518315
36piRNA metabolic process (GO:0034587)4.03412187
37spermatogenesis (GO:0007283)4.03355599
38male gamete generation (GO:0048232)4.03046927
39cellular ketone body metabolic process (GO:0046950)4.02516638
40DNA packaging (GO:0006323)3.99349165
41chromosome condensation (GO:0030261)3.96571537
42DNA methylation involved in gamete generation (GO:0043046)3.85989160
43binding of sperm to zona pellucida (GO:0007339)3.85416224
44calcium ion-dependent exocytosis (GO:0017156)3.83864707
45motile cilium assembly (GO:0044458)3.80463478
46gamete generation (GO:0007276)3.73599497
47microtubule severing (GO:0051013)3.67070796
48seminiferous tubule development (GO:0072520)3.63619248
49spermatid nucleus differentiation (GO:0007289)3.61139741
50single fertilization (GO:0007338)3.46026442
51negative regulation of Rho protein signal transduction (GO:0035024)3.40198073
52ketone body metabolic process (GO:1902224)3.40076325
53male meiosis (GO:0007140)3.33465257
54regulation of centriole replication (GO:0046599)3.30858291
55organic cation transport (GO:0015695)3.29500434
56rRNA catabolic process (GO:0016075)3.27932196
57histone mRNA catabolic process (GO:0071044)3.25843074
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23202112
59detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.22020011
60photoreceptor cell maintenance (GO:0045494)3.20511100
61microtubule nucleation (GO:0007020)3.20089028
62chromatin silencing (GO:0006342)3.19453871
63cilium organization (GO:0044782)3.13678742
64RNA destabilization (GO:0050779)3.13436523
65germ cell development (GO:0007281)3.12930581
66cilium assembly (GO:0042384)3.11224223
67regulation of meiosis I (GO:0060631)3.08240289
68fertilization (GO:0009566)3.05789954
69regulation of microtubule-based movement (GO:0060632)2.98881875
70cell wall macromolecule catabolic process (GO:0016998)2.96508661
71cell wall macromolecule metabolic process (GO:0044036)2.96494879
72intra-Golgi vesicle-mediated transport (GO:0006891)2.93235183
73L-fucose catabolic process (GO:0042355)2.88257716
74fucose catabolic process (GO:0019317)2.88257716
75L-fucose metabolic process (GO:0042354)2.88257716
76cellular process involved in reproduction in multicellular organism (GO:0022412)2.88203270
77histone H3-K9 methylation (GO:0051567)2.87510149
78negative regulation of cAMP-mediated signaling (GO:0043951)2.87305260
79multicellular organismal reproductive process (GO:0048609)2.86068140
80Golgi to endosome transport (GO:0006895)2.83803197
81intraciliary transport (GO:0042073)2.78886790
82male meiosis I (GO:0007141)2.77000463
83histone H3-K9 demethylation (GO:0033169)2.75949358
84nephron tubule morphogenesis (GO:0072078)2.75630940
85nephron epithelium morphogenesis (GO:0072088)2.75630940
86negative regulation of gene expression, epigenetic (GO:0045814)2.69983143
87negative regulation of inclusion body assembly (GO:0090084)2.69285133
88histone H3-K9 modification (GO:0061647)2.64650284
89regulation of transcription involved in cell fate commitment (GO:0060850)2.61183999
90coenzyme catabolic process (GO:0009109)2.59303538
91peptidyl-lysine trimethylation (GO:0018023)2.58956626
92intra-S DNA damage checkpoint (GO:0031573)2.58153399
93sexual reproduction (GO:0019953)2.57245708
94histone H3-K4 trimethylation (GO:0080182)2.55157640
95brain morphogenesis (GO:0048854)2.54048237
96epithelial cell fate commitment (GO:0072148)2.52468774
97cellular component assembly involved in morphogenesis (GO:0010927)2.50560083
98left/right axis specification (GO:0070986)2.50232361
99mast cell activation involved in immune response (GO:0002279)2.49157493
100mast cell degranulation (GO:0043303)2.49157493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.10768033
2IGF1R_20145208_ChIP-Seq_DFB_Human2.70488604
3TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38063831
4POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.38063831
5VDR_22108803_ChIP-Seq_LS180_Human2.35291214
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33080888
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.32070888
8* ER_23166858_ChIP-Seq_MCF-7_Human2.28466304
9FUS_26573619_Chip-Seq_HEK293_Human2.25939819
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.25543609
11GBX2_23144817_ChIP-Seq_PC3_Human2.20980703
12CBP_20019798_ChIP-Seq_JUKART_Human2.14837560
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.14837560
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14008962
15* WDR5_24793694_ChIP-Seq_LNCAP_Human1.95863104
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79547776
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.78536951
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.72971957
19DROSHA_22980978_ChIP-Seq_HELA_Human1.71840545
20P300_19829295_ChIP-Seq_ESCs_Human1.68264272
21ETV2_25802403_ChIP-Seq_MESCs_Mouse1.67155547
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65483247
23TAF15_26573619_Chip-Seq_HEK293_Human1.64422883
24ERA_21632823_ChIP-Seq_H3396_Human1.64211586
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64157135
26NANOG_20526341_ChIP-Seq_ESCs_Human1.59050002
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56436823
28STAT3_23295773_ChIP-Seq_U87_Human1.53602766
29MYC_19829295_ChIP-Seq_ESCs_Human1.53255115
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52758098
31KLF5_20875108_ChIP-Seq_MESCs_Mouse1.49469302
32GATA3_21878914_ChIP-Seq_MCF-7_Human1.43195684
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43091099
34RUNX2_22187159_ChIP-Seq_PCA_Human1.42421411
35BCAT_22108803_ChIP-Seq_LS180_Human1.42186222
36EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.41014836
37OCT4_20526341_ChIP-Seq_ESCs_Human1.40877415
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39070153
39IRF1_19129219_ChIP-ChIP_H3396_Human1.38572420
40* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37869806
41ETV1_20927104_ChIP-Seq_GIST48_Human1.36484623
42TCF4_23295773_ChIP-Seq_U87_Human1.36251948
43* TBL1_22424771_ChIP-Seq_293T_Human1.33779529
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31862472
45* AR_25329375_ChIP-Seq_VCAP_Human1.31613783
46FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30626243
47SMAD4_21799915_ChIP-Seq_A2780_Human1.30576978
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30350280
49RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28175164
50RAC3_21632823_ChIP-Seq_H3396_Human1.27477478
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.27423081
52SMAD4_21741376_ChIP-Seq_EPCs_Human1.27207449
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27074628
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.26622509
55EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.25580089
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25163171
57* HOXB7_26014856_ChIP-Seq_BT474_Human1.24724293
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24549611
59NCOR_22424771_ChIP-Seq_293T_Human1.23612450
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22780261
61NANOG_19829295_ChIP-Seq_ESCs_Human1.22671928
62SOX2_19829295_ChIP-Seq_ESCs_Human1.22671928
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.22641979
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21678213
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21189666
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20810244
67RBPJ_21746931_ChIP-Seq_IB4_Human1.20592504
68* NFYA_21822215_ChIP-Seq_K562_Human1.20513377
69* NFYB_21822215_ChIP-Seq_K562_Human1.19153527
70* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18344670
71SMRT_27268052_Chip-Seq_Bcells_Human1.17655247
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17360091
73* HNFA_21074721_ChIP-Seq_CACO-2_Human1.17236979
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17071481
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.16578911
76EZH2_22144423_ChIP-Seq_EOC_Human1.16577179
77CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16293528
78GATA3_26560356_Chip-Seq_TH1_Human1.15630663
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14847929
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14694470
81CEBPB_22108803_ChIP-Seq_LS180_Human1.14192494
82TCF4_22108803_ChIP-Seq_LS180_Human1.12651275
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12576528
84PHF8_20622853_ChIP-Seq_HELA_Human1.12160371
85E2F1_20622854_ChIP-Seq_HELA_Human1.08987548
86BCL6_27268052_Chip-Seq_Bcells_Human1.08624348
87TAF2_19829295_ChIP-Seq_ESCs_Human1.08575440
88TP53_22573176_ChIP-Seq_HFKS_Human1.08139244
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08107033
90PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08071384
91E2F1_17053090_ChIP-ChIP_MCF-7_Human1.07174637
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07172336
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.05778611
94PHF8_20622854_ChIP-Seq_HELA_Human1.05666704
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05574812
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.05574812
97* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.05276702
98AR_21572438_ChIP-Seq_LNCaP_Human1.01903842
99RUNX_20019798_ChIP-Seq_JUKART_Human1.01603525
100* SMAD3_21741376_ChIP-Seq_ESCs_Human1.01590504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.11375129
2MP0005377_hearing/vestibular/ear_phenot4.02859753
3MP0003878_abnormal_ear_physiology4.02859753
4MP0003698_abnormal_male_reproductive2.97899176
5MP0001929_abnormal_gametogenesis2.71019838
6MP0008877_abnormal_DNA_methylation2.55777645
7MP0002132_abnormal_respiratory_system2.49601132
8MP0008995_early_reproductive_senescence2.31411933
9MP0003787_abnormal_imprinting2.24761890
10MP0005379_endocrine/exocrine_gland_phen2.10535167
11MP0003195_calcinosis2.06896868
12MP0002102_abnormal_ear_morphology1.98593691
13MP0005551_abnormal_eye_electrophysiolog1.94069627
14MP0003646_muscle_fatigue1.93456867
15MP0001485_abnormal_pinna_reflex1.87587527
16MP0002138_abnormal_hepatobiliary_system1.76065859
17MP0001486_abnormal_startle_reflex1.75330792
18MP0002653_abnormal_ependyma_morphology1.75293761
19MP0003880_abnormal_central_pattern1.65921144
20MP0003011_delayed_dark_adaptation1.65281999
21MP0005670_abnormal_white_adipose1.64971077
22MP0008058_abnormal_DNA_repair1.61895508
23MP0002210_abnormal_sex_determination1.60228943
24MP0001984_abnormal_olfaction1.46985561
25MP0002928_abnormal_bile_duct1.46819976
26MP0003172_abnormal_lysosome_physiology1.42556065
27MP0001145_abnormal_male_reproductive1.40564119
28MP0002161_abnormal_fertility/fecundity1.38441483
29MP0003136_yellow_coat_color1.36795595
30MP0000653_abnormal_sex_gland1.36326055
31MP0005499_abnormal_olfactory_system1.34149367
32MP0005394_taste/olfaction_phenotype1.34149367
33MP0005310_abnormal_salivary_gland1.33366279
34MP0008789_abnormal_olfactory_epithelium1.32911241
35MP0001968_abnormal_touch/_nociception1.28794266
36MP0002249_abnormal_larynx_morphology1.27786453
37MP0005253_abnormal_eye_physiology1.27074060
38MP0006292_abnormal_olfactory_placode1.25526525
39MP0004133_heterotaxia1.19230702
40MP0004742_abnormal_vestibular_system1.18510896
41MP0008004_abnormal_stomach_pH1.17414740
42MP0004043_abnormal_pH_regulation1.14376316
43MP0001501_abnormal_sleep_pattern1.08965095
44MP0000427_abnormal_hair_cycle1.07708878
45MP0002282_abnormal_trachea_morphology1.07450750
46MP0003786_premature_aging1.05611615
47MP0003121_genomic_imprinting1.02601351
48MP0001270_distended_abdomen1.02426644
49MP0001963_abnormal_hearing_physiology1.02047300
50MP0001348_abnormal_lacrimal_gland0.97282545
51MP0002272_abnormal_nervous_system0.95957109
52MP0002163_abnormal_gland_morphology0.93995510
53MP0001764_abnormal_homeostasis0.90655811
54MP0009115_abnormal_fat_cell0.89665567
55MP0002557_abnormal_social/conspecific_i0.89103343
56MP0000678_abnormal_parathyroid_gland0.88514725
57MP0000026_abnormal_inner_ear0.88426067
58MP0002837_dystrophic_cardiac_calcinosis0.88332825
59MP0003252_abnormal_bile_duct0.87411097
60MP0003879_abnormal_hair_cell0.86587780
61MP0005084_abnormal_gallbladder_morpholo0.86359621
62MP0002229_neurodegeneration0.85699102
63MP0008872_abnormal_physiological_respon0.85411941
64MP0003122_maternal_imprinting0.84887537
65MP0001765_abnormal_ion_homeostasis0.84422670
66MP0000631_abnormal_neuroendocrine_gland0.83390153
67MP0002168_other_aberrant_phenotype0.78869690
68MP0002638_abnormal_pupillary_reflex0.78436567
69MP0002735_abnormal_chemical_nociception0.76187279
70MP0000516_abnormal_urinary_system0.75712792
71MP0005367_renal/urinary_system_phenotyp0.75712792
72MP0008961_abnormal_basal_metabolism0.70246750
73MP0001970_abnormal_pain_threshold0.69879399
74MP0001119_abnormal_female_reproductive0.69118916
75MP0002736_abnormal_nociception_after0.68176539
76MP0004142_abnormal_muscle_tone0.68174229
77MP0003718_maternal_effect0.68076986
78MP0002693_abnormal_pancreas_physiology0.67608408
79MP0005332_abnormal_amino_acid0.67497028
80MP0004859_abnormal_synaptic_plasticity0.67343916
81MP0005395_other_phenotype0.67160854
82MP0002733_abnormal_thermal_nociception0.66543867
83MP0005646_abnormal_pituitary_gland0.66530157
84MP0002067_abnormal_sensory_capabilities0.66222840
85MP0002127_abnormal_cardiovascular_syste0.66181245
86MP0001986_abnormal_taste_sensitivity0.66012560
87MP0004484_altered_response_of0.64242235
88MP0003938_abnormal_ear_development0.63481233
89MP0005448_abnormal_energy_balance0.62794474
90MP0005389_reproductive_system_phenotype0.62477296
91MP0003283_abnormal_digestive_organ0.61838461
92MP0005083_abnormal_biliary_tract0.61762118
93MP0002277_abnormal_respiratory_mucosa0.61744819
94MP0005220_abnormal_exocrine_pancreas0.60849512
95MP0003943_abnormal_hepatobiliary_system0.60760014
96MP0005423_abnormal_somatic_nervous0.60241585
97MP0000955_abnormal_spinal_cord0.59771605
98MP0002572_abnormal_emotion/affect_behav0.59729034
99MP0002160_abnormal_reproductive_system0.59665322
100MP0002752_abnormal_somatic_nervous0.59631739

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)4.60081176
2Severe visual impairment (HP:0001141)4.37996562
3Chronic hepatic failure (HP:0100626)4.28956195
4Attenuation of retinal blood vessels (HP:0007843)4.12488026
5Absent/shortened dynein arms (HP:0200106)3.98723054
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.98723054
7Nephronophthisis (HP:0000090)3.76217940
8Bony spicule pigmentary retinopathy (HP:0007737)3.56261911
9Abnormality of the renal medulla (HP:0100957)3.53538603
10Pancreatic cysts (HP:0001737)3.38223872
11Hypoplastic ischia (HP:0003175)3.34204933
12Abnormal rod and cone electroretinograms (HP:0008323)3.31181209
13True hermaphroditism (HP:0010459)3.20304109
14Pancreatic fibrosis (HP:0100732)3.14365754
15Abnormal respiratory motile cilium morphology (HP:0005938)2.87780074
16Abnormal respiratory epithelium morphology (HP:0012253)2.87780074
17Type II lissencephaly (HP:0007260)2.86891105
18Abnormal ciliary motility (HP:0012262)2.84671294
19Cystic liver disease (HP:0006706)2.84172998
20Abnormality of the aortic arch (HP:0012303)2.77795759
21Abnormality of DNA repair (HP:0003254)2.77585895
22Cerebellar dysplasia (HP:0007033)2.75890898
23Impulsivity (HP:0100710)2.70423700
24Abnormality of macular pigmentation (HP:0008002)2.69673424
25Abnormality of the ischium (HP:0003174)2.68444034
26Medial flaring of the eyebrow (HP:0010747)2.62692611
27Abnormality of midbrain morphology (HP:0002418)2.62006325
28Molar tooth sign on MRI (HP:0002419)2.62006325
29Abnormal respiratory motile cilium physiology (HP:0012261)2.57219967
30Tubular atrophy (HP:0000092)2.57143140
31Male infertility (HP:0003251)2.51956736
32Facial shape deformation (HP:0011334)2.49115870
33Potter facies (HP:0002009)2.49115870
34Abnormality of the renal cortex (HP:0011035)2.48654019
35Aplasia/Hypoplasia of the earlobes (HP:0009906)2.42002887
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.39450139
37Tubulointerstitial abnormality (HP:0001969)2.38320741
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.36393545
39Polydipsia (HP:0001959)2.36117717
40Abnormal drinking behavior (HP:0030082)2.36117717
41Hyperkalemia (HP:0002153)2.35955429
42Abnormal hair whorl (HP:0010721)2.35259754
43Poor coordination (HP:0002370)2.33137494
44Occipital encephalocele (HP:0002085)2.26960954
45Congenital primary aphakia (HP:0007707)2.25918456
46Truncal obesity (HP:0001956)2.21874654
47Gait imbalance (HP:0002141)2.21491167
48Congenital hepatic fibrosis (HP:0002612)2.21042424
49Bell-shaped thorax (HP:0001591)2.20479463
50Intestinal atresia (HP:0011100)2.16199928
51Enlarged epiphyses (HP:0010580)2.15667006
52Abnormal biliary tract physiology (HP:0012439)2.11699789
53Bile duct proliferation (HP:0001408)2.11699789
54Hypoplasia of the thymus (HP:0000778)2.09709208
55Nephrogenic diabetes insipidus (HP:0009806)2.07526624
56Stage 5 chronic kidney disease (HP:0003774)2.06917354
57Progressive cerebellar ataxia (HP:0002073)2.05376166
58Cone-rod dystrophy (HP:0000548)2.05031630
59Postaxial foot polydactyly (HP:0001830)2.04000506
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99879823
61Azoospermia (HP:0000027)1.97087979
62Abnormal urine output (HP:0012590)1.96898551
63Infertility (HP:0000789)1.96188700
64Absent speech (HP:0001344)1.95145193
65Anencephaly (HP:0002323)1.95019726
66Abnormality of the parathyroid morphology (HP:0011766)1.94750762
67Hypochromic microcytic anemia (HP:0004840)1.93561461
68Sloping forehead (HP:0000340)1.93498849
69Abnormality of dental color (HP:0011073)1.92658422
70Volvulus (HP:0002580)1.91980138
71Male pseudohermaphroditism (HP:0000037)1.91227102
72Optic nerve hypoplasia (HP:0000609)1.86094350
73Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84040999
74Hypoplastic iliac wings (HP:0002866)1.83580790
75Genital tract atresia (HP:0001827)1.82627359
76Polyuria (HP:0000103)1.82605071
77Double outlet right ventricle (HP:0001719)1.80925891
78Congenital malformation of the right heart (HP:0011723)1.80925891
79Panhypogammaglobulinemia (HP:0003139)1.80622683
80Widely patent fontanelles and sutures (HP:0004492)1.79799503
81Vaginal atresia (HP:0000148)1.79755306
82Hand muscle atrophy (HP:0009130)1.79522880
83Growth hormone deficiency (HP:0000824)1.79396105
84Retinal dysplasia (HP:0007973)1.77106466
85Amelogenesis imperfecta (HP:0000705)1.77032943
86Hypophosphatemic rickets (HP:0004912)1.75231066
87Asymmetric septal hypertrophy (HP:0001670)1.73439340
88Abnormality of the nasal septum (HP:0000419)1.73413155
89Retinitis pigmentosa (HP:0000510)1.72774855
90Sclerocornea (HP:0000647)1.72537280
91Ependymoma (HP:0002888)1.72173433
92Abnormality of renal excretion (HP:0011036)1.71047894
93Type II diabetes mellitus (HP:0005978)1.70464637
94Bronchiectasis (HP:0002110)1.69146190
95Abnormal spermatogenesis (HP:0008669)1.68900938
96Hyperventilation (HP:0002883)1.68802325
97Median cleft lip (HP:0000161)1.68016843
98Optic nerve coloboma (HP:0000588)1.67373680
99Abnormality of the pubic bones (HP:0003172)1.65099417
100Renal dysplasia (HP:0000110)1.63085165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.14754657
2FRK3.82243827
3MAP4K23.76859916
4INSRR3.42202475
5BRD42.57985131
6WNK42.51422286
7BMPR1B2.45676870
8NME12.35993260
9NUAK12.20540662
10PINK11.99944164
11CASK1.96434657
12WNK31.62275267
13TNK21.59007440
14NTRK31.57072038
15AKT31.52935655
16PLK21.52408697
17STK391.51833855
18MAP3K71.50358527
19TXK1.46583615
20MAPK151.42463161
21PRKD31.41802980
22MAP3K41.38492159
23ACVR1B1.38384186
24LATS11.35706928
25NLK1.34519272
26TNIK1.31648754
27CAMK1G1.31283292
28PNCK1.30922467
29TRIM281.28322004
30MARK31.23299766
31STK38L1.21998027
32MAP2K61.20986905
33STK381.19413361
34MUSK1.17243013
35FGFR21.16314063
36MAP4K11.15738551
37WNK11.14292971
38MKNK21.12841587
39OXSR11.09329793
40CDK31.03061217
41BCR0.95993946
42FES0.95220581
43EPHA40.93602200
44PIK3CG0.93315586
45PRKAA20.91386595
46STK30.88750317
47TEC0.88500548
48CAMK10.87113639
49TAOK30.86882817
50PAK30.82702992
51PTK2B0.82436838
52ZAK0.82203392
53SIK20.81310151
54SIK30.79547669
55DDR20.78215343
56ADRBK20.77810728
57PRKCQ0.76250092
58PDK10.75788060
59ITK0.75507122
60BRSK20.74209970
61MAPK130.73314491
62MKNK10.73227236
63MAP2K70.72269804
64DYRK1B0.71704451
65STK110.71273267
66MST1R0.69859977
67MAP2K40.68835536
68FER0.66318546
69MARK20.65031956
70BTK0.59791570
71SGK20.59148064
72SGK10.58531983
73BLK0.57179180
74ERBB20.55381407
75DAPK20.53786544
76GRK10.49431320
77PRKAA10.49386553
78IKBKB0.48167177
79SGK2230.46404487
80SGK4940.46404487
81CAMK1D0.43594777
82PDPK10.40983930
83PRKG10.40601241
84RIPK40.40393554
85PRKCZ0.37882454
86GSK3B0.37341982
87ATM0.36666498
88MAPK10.35778868
89NEK20.35255248
90PRKCG0.34660397
91DYRK30.33795158
92ATR0.33783640
93DYRK1A0.32336702
94TGFBR10.31708888
95CHEK10.31657124
96MAPK80.31321541
97CDK190.31166732
98CHUK0.29735528
99ROCK10.29434693
100LYN0.29429012

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.93671644
2Olfactory transduction_Homo sapiens_hsa047403.37400158
3Butanoate metabolism_Homo sapiens_hsa006503.13389906
4Phototransduction_Homo sapiens_hsa047442.45077653
5ABC transporters_Homo sapiens_hsa020102.40700328
6Fanconi anemia pathway_Homo sapiens_hsa034602.21864879
7Regulation of autophagy_Homo sapiens_hsa041402.05007444
8Glycerophospholipid metabolism_Homo sapiens_hsa005642.02719066
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97159000
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89644838
11Dorso-ventral axis formation_Homo sapiens_hsa043201.85931200
12Basal transcription factors_Homo sapiens_hsa030221.78275811
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75949474
14Taste transduction_Homo sapiens_hsa047421.70008908
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.68201038
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.62508031
17Type I diabetes mellitus_Homo sapiens_hsa049401.62506933
18Linoleic acid metabolism_Homo sapiens_hsa005911.54418177
19Propanoate metabolism_Homo sapiens_hsa006401.49105448
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44861562
21Primary immunodeficiency_Homo sapiens_hsa053401.36712171
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36416749
23Non-homologous end-joining_Homo sapiens_hsa034501.35899653
24Fatty acid biosynthesis_Homo sapiens_hsa000611.32789777
25Nicotine addiction_Homo sapiens_hsa050331.32609745
26RNA transport_Homo sapiens_hsa030131.28994046
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28854753
28Inositol phosphate metabolism_Homo sapiens_hsa005621.26442572
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24499526
30Allograft rejection_Homo sapiens_hsa053301.22077457
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18505245
32Autoimmune thyroid disease_Homo sapiens_hsa053201.13778644
33Type II diabetes mellitus_Homo sapiens_hsa049301.09887085
34Salivary secretion_Homo sapiens_hsa049701.09762240
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09320003
36Graft-versus-host disease_Homo sapiens_hsa053321.08177233
37Lysine degradation_Homo sapiens_hsa003101.06275267
38Homologous recombination_Homo sapiens_hsa034401.05761185
39RNA degradation_Homo sapiens_hsa030181.05564746
40mRNA surveillance pathway_Homo sapiens_hsa030150.92379459
41Insulin secretion_Homo sapiens_hsa049110.91851869
42Fatty acid degradation_Homo sapiens_hsa000710.90690437
43Glycerolipid metabolism_Homo sapiens_hsa005610.89547529
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88303470
45Fatty acid metabolism_Homo sapiens_hsa012120.85013551
46Herpes simplex infection_Homo sapiens_hsa051680.84058294
47Ether lipid metabolism_Homo sapiens_hsa005650.82968127
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81882680
49Oocyte meiosis_Homo sapiens_hsa041140.81649317
50Hedgehog signaling pathway_Homo sapiens_hsa043400.81007094
51Morphine addiction_Homo sapiens_hsa050320.80523177
52Calcium signaling pathway_Homo sapiens_hsa040200.78078688
53Choline metabolism in cancer_Homo sapiens_hsa052310.77258281
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77065502
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76887867
56Selenocompound metabolism_Homo sapiens_hsa004500.76662383
57Glutamatergic synapse_Homo sapiens_hsa047240.74206578
58Circadian entrainment_Homo sapiens_hsa047130.73453228
59Chemical carcinogenesis_Homo sapiens_hsa052040.73001895
60Retinol metabolism_Homo sapiens_hsa008300.71894855
61Notch signaling pathway_Homo sapiens_hsa043300.70881858
62cAMP signaling pathway_Homo sapiens_hsa040240.70710708
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.68177565
64Circadian rhythm_Homo sapiens_hsa047100.67941980
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67424531
66Nitrogen metabolism_Homo sapiens_hsa009100.63192043
67GABAergic synapse_Homo sapiens_hsa047270.61803339
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57347057
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.56192398
70Peroxisome_Homo sapiens_hsa041460.55224179
71Amphetamine addiction_Homo sapiens_hsa050310.55145647
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53339907
73T cell receptor signaling pathway_Homo sapiens_hsa046600.53127943
74Renin secretion_Homo sapiens_hsa049240.52851074
75Base excision repair_Homo sapiens_hsa034100.51717304
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49879833
77Serotonergic synapse_Homo sapiens_hsa047260.47789216
78Fat digestion and absorption_Homo sapiens_hsa049750.46824543
79Tryptophan metabolism_Homo sapiens_hsa003800.45748923
80Glucagon signaling pathway_Homo sapiens_hsa049220.44894115
81FoxO signaling pathway_Homo sapiens_hsa040680.44848219
82Dopaminergic synapse_Homo sapiens_hsa047280.43456396
83Arachidonic acid metabolism_Homo sapiens_hsa005900.42892386
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42277136
85Purine metabolism_Homo sapiens_hsa002300.41346344
86Measles_Homo sapiens_hsa051620.40241399
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38742121
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37283874
89beta-Alanine metabolism_Homo sapiens_hsa004100.36938817
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.36888465
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33925820
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33313882
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32445143
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32154768
95Influenza A_Homo sapiens_hsa051640.32077273
96Arginine and proline metabolism_Homo sapiens_hsa003300.31033707
97Oxytocin signaling pathway_Homo sapiens_hsa049210.30865207
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.30662556
99MAPK signaling pathway_Homo sapiens_hsa040100.30291732
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.30228287

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