ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	7.61800437
2	sperm motility (GO:0030317)	7.21981877
3	establishment of protein localization to Golgi (GO:0072600)	7.10259215
4	protein targeting to Golgi (GO:0000042)	7.04829495
5	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.62267409
6	single strand break repair (GO:0000012)	6.19773075
7	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.19389137
8	phosphatidylethanolamine metabolic process (GO:0046337)	5.79503476
9	* regulation of ARF GTPase activity (GO:0032312)	5.71859188
10	fusion of sperm to egg plasma membrane (GO:0007342)	5.65199738
11	spermatid development (GO:0007286)	5.29266985
12	chromosome condensation (GO:0030261)	5.09416008
13	DNA packaging (GO:0006323)	5.05772893
14	protein localization to Golgi apparatus (GO:0034067)	5.03927403
15	sperm capacitation (GO:0048240)	4.96389250
16	multicellular organism reproduction (GO:0032504)	4.89271446
17	regulation of Rab GTPase activity (GO:0032313)	4.49467123
18	positive regulation of Rab GTPase activity (GO:0032851)	4.49467123
19	plasma membrane fusion (GO:0045026)	4.44340433
20	motile cilium assembly (GO:0044458)	4.28840425
21	cellular ketone body metabolic process (GO:0046950)	4.28086785
22	sperm-egg recognition (GO:0035036)	4.24387716
23	reproduction (GO:0000003)	4.18276294
24	histone H3-K4 trimethylation (GO:0080182)	4.03018104
25	cilium or flagellum-dependent cell motility (GO:0001539)	4.00958628
26	regulation of establishment of cell polarity (GO:2000114)	3.97576795
27	centriole assembly (GO:0098534)	3.82295431
28	binding of sperm to zona pellucida (GO:0007339)	3.81127084
29	cell-cell recognition (GO:0009988)	3.75129105
30	response to pheromone (GO:0019236)	3.65188359
31	protein polyglutamylation (GO:0018095)	3.58807708
32	negative regulation of multicellular organism growth (GO:0040015)	3.54711856
33	spermatid nucleus differentiation (GO:0007289)	3.54364295
34	intra-Golgi vesicle-mediated transport (GO:0006891)	3.53117436
35	spermatogenesis (GO:0007283)	3.52866668
36	male gamete generation (GO:0048232)	3.52169580
37	ketone body metabolic process (GO:1902224)	3.51401699
38	axonemal dynein complex assembly (GO:0070286)	3.49362459
39	receptor recycling (GO:0001881)	3.45874492
40	epithelial cilium movement (GO:0003351)	3.45698899
41	peptidyl-lysine trimethylation (GO:0018023)	3.42945844
42	single fertilization (GO:0007338)	3.41159001
43	cilium movement (GO:0003341)	3.36528643
44	coenzyme catabolic process (GO:0009109)	3.35078628
45	microtubule depolymerization (GO:0007019)	3.32734208
46	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.32410689
47	histone H3-K9 demethylation (GO:0033169)	3.30262586
48	calcium ion-dependent exocytosis (GO:0017156)	3.30164517
49	centriole replication (GO:0007099)	3.28491329
50	seminiferous tubule development (GO:0072520)	3.26960830
51	specification of organ identity (GO:0010092)	3.20837006
52	gamete generation (GO:0007276)	3.20824465
53	microtubule polymerization or depolymerization (GO:0031109)	3.15135311
54	nuclear pore complex assembly (GO:0051292)	3.14068686
55	regulation of interleukin-13 production (GO:0032656)	3.12824420
56	germ cell development (GO:0007281)	3.11976236
57	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.10045935
58	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.09725861
59	insulin-like growth factor receptor signaling pathway (GO:0048009)	3.09616808
60	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.08744629
61	heart field specification (GO:0003128)	3.08360034
62	secondary heart field specification (GO:0003139)	3.08360034
63	sex differentiation (GO:0007548)	3.06653481
64	histone lysine demethylation (GO:0070076)	3.06447882
65	regulation of cilium assembly (GO:1902017)	3.04424751
66	regulation of MHC class I biosynthetic process (GO:0045343)	3.02083295
67	organic cation transport (GO:0015695)	3.00607815
68	positive regulation of protein kinase C signaling (GO:0090037)	2.98679996
69	regulation of cilium movement (GO:0003352)	2.98301777
70	peptidyl-lysine methylation (GO:0018022)	2.95612581
71	histone demethylation (GO:0016577)	2.92089257
72	histone H3-K36 demethylation (GO:0070544)	2.91949584
73	sexual reproduction (GO:0019953)	2.91706167
74	histone lysine methylation (GO:0034968)	2.88993391
75	chromatin silencing (GO:0006342)	2.85377244
76	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.84710901
77	rRNA methylation (GO:0031167)	2.83587704
78	negative regulation of inclusion body assembly (GO:0090084)	2.78088178
79	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.77016405
80	carnitine shuttle (GO:0006853)	2.76940927
81	mRNA cleavage (GO:0006379)	2.76769915
82	histone H3-K4 methylation (GO:0051568)	2.71137995
83	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.69596865
84	microtubule severing (GO:0051013)	2.69422309
85	histone H3-K9 methylation (GO:0051567)	2.69195923
86	somite rostral/caudal axis specification (GO:0032525)	2.68698162
87	coronary vasculature morphogenesis (GO:0060977)	2.68657775
88	regulation of interleukin-5 production (GO:0032674)	2.67071082
89	phosphatidylcholine biosynthetic process (GO:0006656)	2.66940203
90	protein dealkylation (GO:0008214)	2.66349868
91	protein demethylation (GO:0006482)	2.66349868
92	fertilization (GO:0009566)	2.65508736
93	nucleus organization (GO:0006997)	2.64439816
94	response to acidic pH (GO:0010447)	2.63197849
95	cardiac ventricle formation (GO:0003211)	2.60034850
96	necroptotic process (GO:0070266)	2.59031811
97	multicellular organismal reproductive process (GO:0048609)	2.55869700
98	indole-containing compound catabolic process (GO:0042436)	2.53590683
99	indolalkylamine catabolic process (GO:0046218)	2.53590683
100	tryptophan catabolic process (GO:0006569)	2.53590683

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.01168575
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.51530641
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.41798378
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36302180
5	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.28767717
6	ER_23166858_ChIP-Seq_MCF-7_Human	2.25660047
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.24418811
8	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.11588375
9	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.89140910
10	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.86475620
11	DROSHA_22980978_ChIP-Seq_HELA_Human	1.84074061
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81881043
13	CBP_20019798_ChIP-Seq_JUKART_Human	1.78724426
14	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.78724426
15	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77342298
16	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.77342298
17	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.75198179
18	ERA_21632823_ChIP-Seq_H3396_Human	1.74762864
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.74629356
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.70465595
21	VDR_22108803_ChIP-Seq_LS180_Human	1.67858409
22	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.66443822
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.66107515
24	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.66067552
25	AR_21572438_ChIP-Seq_LNCaP_Human	1.61604293
26	OCT4_20526341_ChIP-Seq_ESCs_Human	1.59490003
27	TBL1_22424771_ChIP-Seq_293T_Human	1.58258749
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56013705
29	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.49460369
30	AHR_22903824_ChIP-Seq_MCF-7_Human	1.49110695
31	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.48853781
32	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.46949422
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46194643
34	PHF8_20622854_ChIP-Seq_HELA_Human	1.44515643
35	RAC3_21632823_ChIP-Seq_H3396_Human	1.43042635
36	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.42853796
37	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.40435281
38	NFYB_21822215_ChIP-Seq_K562_Human	1.38928919
39	CTCF_27219007_Chip-Seq_Bcells_Human	1.38635270
40	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.38537525
41	MYC_19829295_ChIP-Seq_ESCs_Human	1.38104716
42	NFYA_21822215_ChIP-Seq_K562_Human	1.37753140
43	E2F1_20622854_ChIP-Seq_HELA_Human	1.34899248
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.34825392
45	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.33921539
46	PHF8_20622853_ChIP-Seq_HELA_Human	1.32989938
47	ETV1_20927104_ChIP-Seq_GIST48_Human	1.31430614
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31028950
49	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.29767548
50	STAT3_23295773_ChIP-Seq_U87_Human	1.29667827
51	RUNX_20019798_ChIP-Seq_JUKART_Human	1.27989974
52	AR_25329375_ChIP-Seq_VCAP_Human	1.26737259
53	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.26330220
54	BCL6_27268052_Chip-Seq_Bcells_Human	1.25699511
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.25485742
56	SMC4_20622854_ChIP-Seq_HELA_Human	1.24312241
57	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.23754288
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.23168623
59	RXR_22108803_ChIP-Seq_LS180_Human	1.22466371
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.21913482
61	RBPJ_21746931_ChIP-Seq_IB4_Human	1.20528255
62	TP63_22573176_ChIP-Seq_HFKS_Human	1.19919196
63	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.18981961
64	P68_20966046_ChIP-Seq_HELA_Human	1.18527129
65	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.17903435
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17655539
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16595527
68	SPI1_23127762_ChIP-Seq_K562_Human	1.16435043
69	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.15901796
70	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.14717567
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14640970
72	P300_27268052_Chip-Seq_Bcells_Human	1.13774453
73	SMAD4_21799915_ChIP-Seq_A2780_Human	1.12038849
74	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10584452
75	BCOR_27268052_Chip-Seq_Bcells_Human	1.10326386
76	TAF2_19829295_ChIP-Seq_ESCs_Human	1.10153739
77	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09969021
78	CEBPB_22108803_ChIP-Seq_LS180_Human	1.09815166
79	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.09515945
80	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08936693
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08917137
82	FUS_26573619_Chip-Seq_HEK293_Human	1.08209722
83	TCF4_23295773_ChIP-Seq_U87_Human	1.06325370
84	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.05820450
85	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.05744714
86	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05575376
87	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05391180
88	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05009277
89	OCT4_19829295_ChIP-Seq_ESCs_Human	1.03779746
90	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.03033502
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02477123
92	SMRT_27268052_Chip-Seq_Bcells_Human	1.02179434
93	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.01635720
94	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.01630477
95	CDX2_22108803_ChIP-Seq_LS180_Human	1.01198470
96	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.00960695
97	TAF15_26573619_Chip-Seq_HEK293_Human	1.00753282
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99436220
99	NCOR_22424771_ChIP-Seq_293T_Human	0.98455779
100	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.98450102

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.18596857
2	MP0003646_muscle_fatigue	3.88728694
3	MP0005670_abnormal_white_adipose	3.86441624
4	MP0005360_urolithiasis	2.83999212
5	MP0003698_abnormal_male_reproductive	2.79540275
6	MP0008004_abnormal_stomach_pH	2.69878766
7	MP0001348_abnormal_lacrimal_gland	2.61970173
8	MP0002163_abnormal_gland_morphology	2.60755736
9	MP0003172_abnormal_lysosome_physiology	2.59682865
10	MP0002138_abnormal_hepatobiliary_system	2.55787501
11	MP0002132_abnormal_respiratory_system	2.52891218
12	MP0002837_dystrophic_cardiac_calcinosis	2.35832147
13	MP0001929_abnormal_gametogenesis	2.29945850
14	MP0005379_endocrine/exocrine_gland_phen	2.26531688
15	MP0000569_abnormal_digit_pigmentation	2.24924696
16	MP0001873_stomach_inflammation	2.12175982
17	MP0002234_abnormal_pharynx_morphology	2.10045433
18	MP0003878_abnormal_ear_physiology	2.00278537
19	MP0005377_hearing/vestibular/ear_phenot	2.00278537
20	MP0004510_myositis	1.92571758
21	MP0005310_abnormal_salivary_gland	1.91838027
22	MP0000749_muscle_degeneration	1.89652729
23	MP0001661_extended_life_span	1.58885358
24	MP0002127_abnormal_cardiovascular_syste	1.51969192
25	MP0003252_abnormal_bile_duct	1.46353200
26	MP0004036_abnormal_muscle_relaxation	1.39976555
27	MP0002161_abnormal_fertility/fecundity	1.38881964
28	MP0004043_abnormal_pH_regulation	1.36842207
29	MP0005551_abnormal_eye_electrophysiolog	1.36810096
30	MP0005083_abnormal_biliary_tract	1.26478161
31	MP0004084_abnormal_cardiac_muscle	1.19782982
32	MP0009115_abnormal_fat_cell	1.18518387
33	MP0002822_catalepsy	1.17469193
34	MP0003045_fibrosis	1.17062005
35	MP0003011_delayed_dark_adaptation	1.14199217
36	MP0001986_abnormal_taste_sensitivity	1.11469160
37	MP0003879_abnormal_hair_cell	1.10645344
38	MP0000678_abnormal_parathyroid_gland	1.09127035
39	MP0004742_abnormal_vestibular_system	1.07960816
40	MP0002210_abnormal_sex_determination	1.07358200
41	MP0005666_abnormal_adipose_tissue	1.06483817
42	MP0008995_early_reproductive_senescence	1.06078107
43	MP0004381_abnormal_hair_follicle	1.01929275
44	MP0000465_gastrointestinal_hemorrhage	1.01540470
45	MP0003763_abnormal_thymus_physiology	1.00963169
46	MP0000371_diluted_coat_color	0.99840049
47	MP0004233_abnormal_muscle_weight	0.98065849
48	MP0002693_abnormal_pancreas_physiology	0.97612860
49	MP0005334_abnormal_fat_pad	0.93703785
50	MP0008775_abnormal_heart_ventricle	0.93588718
51	MP0002229_neurodegeneration	0.90150867
52	MP0001666_abnormal_nutrient_absorption	0.89536170
53	MP0005266_abnormal_metabolism	0.87553688
54	MP0003936_abnormal_reproductive_system	0.87313969
55	MP0005375_adipose_tissue_phenotype	0.86669574
56	MP0001270_distended_abdomen	0.85956307
57	MP0001764_abnormal_homeostasis	0.84830055
58	MP0000026_abnormal_inner_ear	0.84353631
59	MP0002168_other_aberrant_phenotype	0.84266524
60	MP0004145_abnormal_muscle_electrophysio	0.83393947
61	MP0002269_muscular_atrophy	0.83337962
62	MP0000653_abnormal_sex_gland	0.82941435
63	MP0004085_abnormal_heartbeat	0.82078397
64	MP0005647_abnormal_sex_gland	0.81182612
65	MP0004264_abnormal_extraembryonic_tissu	0.80764347
66	MP0001145_abnormal_male_reproductive	0.80249104
67	MP0005058_abnormal_lysosome_morphology	0.79412721
68	MP0001765_abnormal_ion_homeostasis	0.79048975
69	MP0010329_abnormal_lipoprotein_level	0.78941457
70	MP0001485_abnormal_pinna_reflex	0.78581077
71	MP0002653_abnormal_ependyma_morphology	0.77759603
72	MP0001529_abnormal_vocalization	0.77373752
73	MP0002249_abnormal_larynx_morphology	0.75961838
74	MP0005451_abnormal_body_composition	0.75772919
75	MP0009840_abnormal_foam_cell	0.75348904
76	MP0003787_abnormal_imprinting	0.74492496
77	MP0002876_abnormal_thyroid_physiology	0.74170758
78	MP0004087_abnormal_muscle_fiber	0.73839870
79	MP0008877_abnormal_DNA_methylation	0.72628474
80	MP0004130_abnormal_muscle_cell	0.71420692
81	MP0005253_abnormal_eye_physiology	0.71334223
82	MP0001664_abnormal_digestion	0.70176604
83	MP0003195_calcinosis	0.70068526
84	MP0001835_abnormal_antigen_presentation	0.68682168
85	MP0005499_abnormal_olfactory_system	0.63497453
86	MP0005394_taste/olfaction_phenotype	0.63497453
87	MP0005376_homeostasis/metabolism_phenot	0.63333350
88	MP0001501_abnormal_sleep_pattern	0.62591481
89	MP0000470_abnormal_stomach_morphology	0.62009990
90	MP0000003_abnormal_adipose_tissue	0.61566562
91	MP0000230_abnormal_systemic_arterial	0.61154976
92	MP0001963_abnormal_hearing_physiology	0.61054528
93	MP0005395_other_phenotype	0.60891225
94	MP0005248_abnormal_Harderian_gland	0.60701343
95	MP0000538_abnormal_urinary_bladder	0.59766649
96	MP0001800_abnormal_humoral_immune	0.59609484
97	MP0010630_abnormal_cardiac_muscle	0.59543136
98	MP0005330_cardiomyopathy	0.59098104
99	MP0003136_yellow_coat_color	0.58483999
100	MP0002118_abnormal_lipid_homeostasis	0.57060286

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Autoimmune thrombocytopenia (HP:0001973)	5.64392154
2	Severe visual impairment (HP:0001141)	5.19722899
3	Abnormal delayed hypersensitivity skin test (HP:0002963)	4.96121509
4	Autoimmune hemolytic anemia (HP:0001890)	4.70536115
5	Enlarged epiphyses (HP:0010580)	4.65872259
6	Hypoplastic ischia (HP:0003175)	3.80011104
7	Eosinophilia (HP:0001880)	3.74100364
8	Hyperkalemia (HP:0002153)	3.70414076
9	Hypochromic anemia (HP:0001931)	3.65648926
10	Abnormality of the columella (HP:0009929)	3.62926827
11	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.44556651
12	Tubulointerstitial nephritis (HP:0001970)	3.42979491
13	Granulocytopenia (HP:0001913)	3.40809953
14	Increased IgM level (HP:0003496)	3.37874472
15	Chronic hepatic failure (HP:0100626)	3.36525623
16	Abnormality of the ischium (HP:0003174)	3.24852212
17	Neonatal hypoglycemia (HP:0001998)	3.13509261
18	Bony spicule pigmentary retinopathy (HP:0007737)	3.09493248
19	Postural instability (HP:0002172)	3.08815682
20	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.99461789
21	Absent/shortened dynein arms (HP:0200106)	2.99461789
22	Genetic anticipation (HP:0003743)	2.80998244
23	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.80808589
24	Abnormality of the aortic arch (HP:0012303)	2.77513020
25	Progressive cerebellar ataxia (HP:0002073)	2.67187466
26	Abnormality of the fingertips (HP:0001211)	2.65886092
27	Abnormality of eosinophils (HP:0001879)	2.64949409
28	Abnormality of macular pigmentation (HP:0008002)	2.64495113
29	Abnormality of T cell physiology (HP:0011840)	2.59802375
30	Abnormality of chloride homeostasis (HP:0011422)	2.56545211
31	Attenuation of retinal blood vessels (HP:0007843)	2.54288179
32	Bell-shaped thorax (HP:0001591)	2.53650168
33	Abnormality of the hepatic vasculature (HP:0006707)	2.52339536
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.49150995
35	Abnormality of the renal medulla (HP:0100957)	2.48903018
36	Nephronophthisis (HP:0000090)	2.46607466
37	Resting tremor (HP:0002322)	2.42148101
38	Gaze-evoked nystagmus (HP:0000640)	2.41546664
39	Abnormality of T cell number (HP:0011839)	2.39461448
40	Hypoplasia of the thymus (HP:0000778)	2.38971660
41	Abnormal ciliary motility (HP:0012262)	2.37458775
42	Dysmetric saccades (HP:0000641)	2.30982530
43	Truncal obesity (HP:0001956)	2.27885780
44	Congenital sensorineural hearing impairment (HP:0008527)	2.27802070
45	Male infertility (HP:0003251)	2.26632885
46	Asymmetric septal hypertrophy (HP:0001670)	2.19053976
47	Abnormal pancreas size (HP:0012094)	2.18241949
48	Infertility (HP:0000789)	2.15011096
49	Lip pit (HP:0100267)	2.12759931
50	Birth length less than 3rd percentile (HP:0003561)	2.12090520
51	Heterotopia (HP:0002282)	2.11054207
52	Impulsivity (HP:0100710)	2.06851731
53	Easy fatigability (HP:0003388)	2.06602697
54	Long clavicles (HP:0000890)	2.06462765
55	Renal dysplasia (HP:0000110)	2.01768259
56	Prostate neoplasm (HP:0100787)	2.00728383
57	Hypophosphatemic rickets (HP:0004912)	1.99878169
58	Widely patent fontanelles and sutures (HP:0004492)	1.99676781
59	Colitis (HP:0002583)	1.98430492
60	Insulin-resistant diabetes mellitus (HP:0000831)	1.97230110
61	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.95273316
62	Abnormal respiratory motile cilium physiology (HP:0012261)	1.95256322
63	Sex reversal (HP:0012245)	1.93317073
64	Abnormal sex determination (HP:0012244)	1.93317073
65	Hypoalphalipoproteinemia (HP:0003233)	1.93141935
66	Deep palmar crease (HP:0006191)	1.91831758
67	Abnormality of potassium homeostasis (HP:0011042)	1.91131388
68	Tubular atrophy (HP:0000092)	1.90926587
69	Slow saccadic eye movements (HP:0000514)	1.90189102
70	Stage 5 chronic kidney disease (HP:0003774)	1.84867434
71	Congenital malformation of the right heart (HP:0011723)	1.84673947
72	Double outlet right ventricle (HP:0001719)	1.84673947
73	Cone-rod dystrophy (HP:0000548)	1.84226250
74	Glucose intolerance (HP:0000833)	1.83132543
75	Cystic liver disease (HP:0006706)	1.82303889
76	Chin dimple (HP:0010751)	1.80291184
77	Gonadal dysgenesis (HP:0000133)	1.80272297
78	Depressed nasal tip (HP:0000437)	1.76458206
79	Abnormal respiratory epithelium morphology (HP:0012253)	1.76127356
80	Abnormal respiratory motile cilium morphology (HP:0005938)	1.76127356
81	Thoracolumbar scoliosis (HP:0002944)	1.75546123
82	Tetany (HP:0001281)	1.75287367
83	True hermaphroditism (HP:0010459)	1.74560568
84	Enlarged kidneys (HP:0000105)	1.74357712
85	Leukocytosis (HP:0001974)	1.73988561
86	Duplicated collecting system (HP:0000081)	1.72006412
87	Abnormality of the renal cortex (HP:0011035)	1.69833351
88	Portal hypertension (HP:0001409)	1.69255219
89	Sandal gap (HP:0001852)	1.68077540
90	Thin bony cortex (HP:0002753)	1.67958533
91	Tubulointerstitial abnormality (HP:0001969)	1.67325849
92	Abnormality of lateral ventricle (HP:0030047)	1.67064588
93	Hyperthyroidism (HP:0000836)	1.63274169
94	Abnormality of DNA repair (HP:0003254)	1.63176364
95	Increased CSF protein (HP:0002922)	1.62470387
96	Clumsiness (HP:0002312)	1.62402538
97	Abnormal urine output (HP:0012590)	1.61405282
98	Hyperventilation (HP:0002883)	1.60193450
99	Bile duct proliferation (HP:0001408)	1.58445065
100	Abnormal biliary tract physiology (HP:0012439)	1.58445065

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.85935662
2	TLK1	3.67343159
3	PINK1	3.41274549
4	PLK4	2.81357085
5	MST1R	2.63853713
6	PIK3CA	2.50303819
7	CDK19	2.48650747
8	CAMK1G	2.44597604
9	BMPR1B	2.41713865
10	MAP4K2	2.32889129
11	MARK3	2.29014696
12	CAMK1D	2.24623789
13	WNK4	2.12410960
14	MAP2K6	1.97929776
15	MAP3K7	1.97023341
16	OXSR1	1.92359178
17	AKT3	1.72917723
18	OBSCN	1.71376716
19	TNK2	1.65932176
20	NME1	1.61481587
21	WNK1	1.60556172
22	DDR2	1.58850160
23	CDK12	1.54957656
24	STK38	1.54589187
25	STK16	1.50984261
26	NEK2	1.41475066
27	PNCK	1.32567923
28	NLK	1.31013555
29	SIK2	1.30559081
30	STK38L	1.26399775
31	PDK1	1.22506647
32	BCR	1.22216685
33	PRKAA2	1.19925206
34	PDPK1	1.16885974
35	PIK3CG	1.11644408
36	TRPM7	1.05022833
37	ICK	1.04298704
38	EEF2K	1.03504042
39	TAOK2	1.00175375
40	BLK	0.99841165
41	MAP3K13	0.94518055
42	MAP3K6	0.93793293
43	RET	0.93723111
44	INSRR	0.91595098
45	ZAK	0.88124174
46	KIT	0.87206866
47	MAPK15	0.86005690
48	BRD4	0.85890383
49	LATS1	0.85263356
50	BTK	0.80637100
51	MARK2	0.75575889
52	MAP3K1	0.74728744
53	NTRK3	0.72886149
54	MAPK12	0.72308074
55	PKN2	0.71653724
56	PRKAA1	0.71566572
57	MTOR	0.68187611
58	MAP2K7	0.67869934
59	WNK3	0.65687192
60	MAP2K3	0.65384412
61	SGK2	0.64535976
62	TGFBR2	0.64126390
63	ACVR1B	0.62600536
64	TNIK	0.61602370
65	CASK	0.60326484
66	CAMK1	0.58174799
67	CDK3	0.57958254
68	TESK1	0.57769970
69	SGK494	0.52382426
70	SGK223	0.52382426
71	PRKD3	0.50744559
72	MAP3K4	0.50343395
73	PDGFRB	0.49141427
74	ERBB2	0.46945576
75	BRAF	0.46094404
76	MAPK11	0.45241088
77	ADRBK2	0.43731099
78	PAK3	0.42285610
79	SGK3	0.42163188
80	PRKG1	0.41405507
81	GRK1	0.40952221
82	PRKCQ	0.40429232
83	STK11	0.40339730
84	MET	0.40035715
85	MAPK1	0.39181836
86	CHEK1	0.37874444
87	TXK	0.36115964
88	CAMK4	0.35448500
89	ITK	0.35032682
90	JAK2	0.32531054
91	FER	0.31292883
92	TEC	0.31132114
93	PTK2B	0.30740592
94	SGK1	0.30411252
95	PRKCG	0.30161664
96	RPS6KA2	0.27882493
97	CDK4	0.27478595
98	ATM	0.25713823
99	MAP4K1	0.25261491
100	IKBKB	0.25139277

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.61498543
2	Olfactory transduction_Homo sapiens_hsa04740	2.44643359
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.37684358
4	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.27508615
5	ABC transporters_Homo sapiens_hsa02010	2.20799485
6	Butanoate metabolism_Homo sapiens_hsa00650	2.07031349
7	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.05465464
8	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.99987355
9	Type II diabetes mellitus_Homo sapiens_hsa04930	1.92440336
10	Other glycan degradation_Homo sapiens_hsa00511	1.77884560
11	African trypanosomiasis_Homo sapiens_hsa05143	1.69771776
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.61909698
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.61619641
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.57674773
15	Allograft rejection_Homo sapiens_hsa05330	1.52918825
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.50462829
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49520313
18	Lysine degradation_Homo sapiens_hsa00310	1.44343019
19	Caffeine metabolism_Homo sapiens_hsa00232	1.42640241
20	Acute myeloid leukemia_Homo sapiens_hsa05221	1.36484049
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23942558
22	mTOR signaling pathway_Homo sapiens_hsa04150	1.23701531
23	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.22544666
24	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.22349074
25	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.19144855
26	Choline metabolism in cancer_Homo sapiens_hsa05231	1.16373505
27	FoxO signaling pathway_Homo sapiens_hsa04068	1.09159007
28	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.08431312
29	Insulin resistance_Homo sapiens_hsa04931	1.05479036
30	PPAR signaling pathway_Homo sapiens_hsa03320	1.04982921
31	Phototransduction_Homo sapiens_hsa04744	1.03568395
32	Glycerolipid metabolism_Homo sapiens_hsa00561	1.03119078
33	Fatty acid degradation_Homo sapiens_hsa00071	1.01209648
34	Influenza A_Homo sapiens_hsa05164	1.00987415
35	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.00213266
36	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99833852
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.97395253
38	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.95000048
39	Measles_Homo sapiens_hsa05162	0.92329624
40	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.92326870
41	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.90876819
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89708956
43	Salivary secretion_Homo sapiens_hsa04970	0.89134921
44	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.88196289
45	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.86487611
46	Apoptosis_Homo sapiens_hsa04210	0.86338069
47	Prolactin signaling pathway_Homo sapiens_hsa04917	0.85919815
48	VEGF signaling pathway_Homo sapiens_hsa04370	0.85907552
49	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.84317746
50	Retinol metabolism_Homo sapiens_hsa00830	0.81988167
51	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.80525103
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.79377937
53	TNF signaling pathway_Homo sapiens_hsa04668	0.77681663
54	cAMP signaling pathway_Homo sapiens_hsa04024	0.77312216
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74163994
56	Endometrial cancer_Homo sapiens_hsa05213	0.73677318
57	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.72180137
58	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.72061527
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.71832569
60	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.71147153
61	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.70832912
62	Glucagon signaling pathway_Homo sapiens_hsa04922	0.69182659
63	Non-small cell lung cancer_Homo sapiens_hsa05223	0.68959757
64	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.68667246
65	ErbB signaling pathway_Homo sapiens_hsa04012	0.67772905
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.66803046
67	Oocyte meiosis_Homo sapiens_hsa04114	0.65261488
68	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.64616318
69	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.64493887
70	Insulin signaling pathway_Homo sapiens_hsa04910	0.64182494
71	Platelet activation_Homo sapiens_hsa04611	0.63782114
72	Complement and coagulation cascades_Homo sapiens_hsa04610	0.63179672
73	Herpes simplex infection_Homo sapiens_hsa05168	0.59404206
74	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.58829307
75	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.58576100
76	Notch signaling pathway_Homo sapiens_hsa04330	0.58134787
77	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.57977099
78	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.57449525
79	MAPK signaling pathway_Homo sapiens_hsa04010	0.56585661
80	GnRH signaling pathway_Homo sapiens_hsa04912	0.56119938
81	Hepatitis B_Homo sapiens_hsa05161	0.54364013
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.53229888
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52554395
84	Gastric acid secretion_Homo sapiens_hsa04971	0.51919615
85	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.51135610
86	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.50899770
87	AMPK signaling pathway_Homo sapiens_hsa04152	0.50417515
88	Taste transduction_Homo sapiens_hsa04742	0.49316833
89	Renin secretion_Homo sapiens_hsa04924	0.49286455
90	Estrogen signaling pathway_Homo sapiens_hsa04915	0.49198525
91	Basal transcription factors_Homo sapiens_hsa03022	0.47470334
92	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.46593757
93	Prostate cancer_Homo sapiens_hsa05215	0.45673619
94	Osteoclast differentiation_Homo sapiens_hsa04380	0.43115572
95	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.43049192
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.42730701
97	Nitrogen metabolism_Homo sapiens_hsa00910	0.40966881
98	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.40053815
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39502871
100	Glioma_Homo sapiens_hsa05214	0.33586408

AGAP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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